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Exploring cancer stem cell niche directed tumor growth. | The finding that only a sub-fraction of tumor cells, so called Cancer Stem Cells (CSC), is endowed with the capacity to initiate new tumors has important consequences for fundamental as well as clinical cancer research. Previously we established by computational modeling techniques that CSC driven tumor growth instigat... | ['Cell Movement', 'Cell Proliferation', 'Humans', 'Models, Biological', 'Neoplasms', 'Neoplastic Stem Cells', 'Stem Cell Niche'] | 20,372,084 | [['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['C04'], ['A11.872.650'], ['G04.366.249']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children. | OBJECTIVE: Modulation of inflammatory status is considered a key component of the overall health effects of exercise. This may be especially relevant in children with obesity (Ob) or type 1 diabetes (T1DM), in which an imbalance between pro- and anti-inflammatory mediators could accelerate onset and progression of card... | ['Adolescent', 'Child', 'Cytokines', 'Diabetes Mellitus, Type 1', 'Exercise', 'Female', 'Humans', 'Male', 'Obesity'] | 21,911,323 | [['M01.060.057'], ['M01.060.406'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Jagged-1-mediated activation of notch signalling induces adipogenesis of adipose-derived stem cells. | OBJECTIVES: Notch signalling plays an important role in many cell activities, involving proliferation, migration, differentiation and cell death. The aim of this study was to investigate effects of such signalling on adipogenesis of mouse adipose-derived stem cells (mASCs).MATERIALS AND METHODS: Jagged1 (50 and 100 ng/... | ['Adipocytes', 'Adipogenesis', 'Adipose Tissue', 'Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'Calcium-Binding Proteins', 'Cells, Cultured', 'Homeodomain Proteins', 'Intercellular Signaling Peptides and Proteins', 'Jagged-1 Protein', 'Membrane Proteins', 'Mice', 'PPAR gamma', 'Rats', 'Receptors, Notch', '... | 23,046,039 | [['A11.329.114'], ['G04.152.149'], ['A10.165.114'], ['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['D12.776.157.125'], ['A11.251'], ['D12.776.260.400'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['D12.644.276.930.500', 'D12.776.157.125.797.500', 'D12.776.543.800.500', 'D23.529.930.500'], ['D12.776.543'], ['B01.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Testicular self-examination and testicular cancer: a cost-utility analysis. | The United States Preventive Services Task Force (USPSTF) has recommended against testicular self-examinations (TSE) or clinical examination for testicular cancer screening. However, in this recommendation there was no consideration of the significant fiscal cost of treating advanced disease versus evaluation of benign... | ['Adolescent', 'Adult', 'Cost-Benefit Analysis', 'Early Detection of Cancer', 'Humans', 'Male', 'Neoplasms, Germ Cell and Embryonal', 'Self-Examination', 'Seminoma', 'Testicular Neoplasms', 'United States', 'Young Adult'] | 25,103,095 | [['M01.060.057'], ['M01.060.116'], ['N03.219.151.125'], ['E01.390.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465'], ['E01.370.600.750', 'F01.145.488.700'], ['C04.557.465.330.800'], ['C04.588.322.762', 'C04.588.945.440.915', 'C12.294.260.937', 'C12.758.409.937', 'C19.344.762', 'C19.391.829.782'], ... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
E-Index for Differentiating Complex Dynamic Traits. | While it is a daunting challenge in current biology to understand how the underlying network of genes regulates complex dynamic traits, functional mapping, a tool for mapping quantitative trait loci (QTLs) and single nucleotide polymorphisms (SNPs), has been applied in a variety of cases to tackle this challenge. Thoug... | ['Algorithms', 'Chromosome Mapping', 'Computational Biology', 'Humans', 'Models, Genetic', 'Polymorphism, Single Nucleotide', 'Quantitative Trait Loci'] | 27,064,292 | [['G17.035', 'L01.224.050'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['G05.365.795.598'], ['G05.360.340.024.380.937']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Replication of the A7(74) strain of Semliki Forest virus is restricted in neurons. | In neonatal mice the A7(74) and L10 strains of Semliki Forest virus (SFV) are virulent. In 3- to 4-week-old mice the L10 strain is virulent, the A7(74) strain is avirulent. Following intraperitoneal inoculation of 3- to 4-week-old mice both strains produce a transient plasma viremia. This is cleared by IgM antibodies. ... | ['Animals', 'Animals, Newborn', 'Antibodies, Viral', 'Blood', 'Brain', 'Mice', 'Mice, SCID', 'Microscopy, Electron', 'Neurons', 'Semliki forest virus', 'Togaviridae Infections', 'Virus Replication'] | 8,393,239 | [['B01.050'], ['B01.050.050.282'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['A12.207.152', 'A15.145'], ['A08.186.211'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.780'], ['E01.370.350.515.402', 'E05.595.402'], ['A08.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. | The maintenance of long-term potentiation (LTP) requires a brief period of accelerated protein synthesis soon after synaptic stimulation, suggesting that an early phase of enhanced translation contributes to stable LTP. The mechanism regulating protein synthesis and the location and identities of mRNAs translated are n... | ['Animals', 'Base Sequence', 'Blotting, Western', 'Dendrites', 'Gene Expression Regulation', 'Immunohistochemistry', 'Long-Term Potentiation', 'Male', 'Molecular Sequence Data', 'Peptide Elongation Factor 1', 'Protein Biosynthesis', 'Protein Kinases', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Signal Transducti... | 15,958,750 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G05.308'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. | BACKGROUND: c-Jun N-terminal kinase (JNK) plays a critical role in UV-induced apoptotic cell death. Although three isoforms are known in mammals, physiological roles of each isoform are still obscure. Furthermore, our recent findings show that serpin squamous cell carcinoma antigen (SCCA1) binds to JNK.OBJECTIVE: To de... | ['Active Transport, Cell Nucleus', 'Adult', 'Antigens, Neoplasm', 'Cell Nucleus', 'Cytoplasm', 'Epidermis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Mitogen-Activated Protein Kinase 10', 'Mitogen-Activated Protein Kinase 8', 'Mitogen-Activated Protein Kinase 9', 'RNA, Messenger', 'Serpins', 'Signal Transduction', 'U... | 16,824,735 | [['G03.143.310.100', 'G03.143.700.100'], ['M01.060.116'], ['D23.050.285'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.913.696.620.682.700.567.374.800', 'D12.644.360.450.340.800',... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[On the effect of biologically active substances (experimental studies) (author's transl)]. | The influence of prolonged Procaine and Turigeran therapy on the cellular kinetics of the mucous membrane of the liver and small intestine has been studied by means of 3H-thymidine histo-autoradiography of a total of 240 12-month-old male Wistar rats. The following observations have been made: 1. The pool of DNA-synthe... | ['Animals', 'Autoradiography', 'DNA', 'Intestinal Mucosa', 'Kinetics', 'Kupffer Cells', 'Liver', 'Male', 'Procaine', 'Rats', 'Time Factors', 'Vitamins'] | 7,281,717 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['D13.444.308'], ['A03.556.124.369', 'A10.615.550.444'], ['G01.374.661', 'G02.111.490'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['D02.241.223.100.050.500.906', 'D02.455... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Application of concept map for the identification of nursing diagnosis]. | This is an experience report, aiming at describing the application of the Concept Map as a strategy to develop critical thinking skills in the identification of priority nursing diagnoses in a clinical situation. An elaborated fictitious clinical case and the concept map, created by using the IHMC CmapTools computer pr... | ['Aged', 'Computer-Assisted Instruction', 'Education, Nursing', 'Female', 'Humans', 'Nursing Diagnosis'] | 22,460,502 | [['M01.060.116.100'], ['I02.903.771.500.208'], ['I02.358.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.508.480.110']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Non-chromogenic peptide substrates for detection of enzymes by means of capacitance changes at metal electrodes. | A new type of substrate for enzyme detection has been developed. The substrate is non-chromogenic and is used in an assay method based on electrode adsorption. The rate of change in the electric capacitance of the electrode is monitored and taken as a measure of the substrate adsorption. Substrate adsorption is in turn... | ['Electrochemistry', 'Electrodes', 'Enzymes', 'Peptides'] | 3,443,697 | [['H01.181.529.307'], ['E07.305.250'], ['D08.811'], ['D12.644']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of p53 protein in advanced head and neck squamous cell carcinoma before and after chemotherapy. | BACKGROUND: The expression of p53 protein has been reported to be in the range of 35% to 67% in head and neck squamous cell carcinoma (HNSCC). Mutations of the gene for p53 protein have been associated with rapidly proliferating tumors, and p53 protein expression has been shown to be a significant predictor of worse su... | ['Adolescent', 'Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carboplatin', 'Carcinoma, Squamous Cell', 'Drug Administration Schedule', 'Head and Neck Neoplasms', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'Mutation', 'Neoplasm, Residual', 'Paclitaxel', 'Retrospective Studies', 'Tumor Suppres... | 9,366,702 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.257.125'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.319.283'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of trophic poisoning with methylmercury on the appetitive elements of the agonistic sequence in fighting-fish (Betta splendens). | The aggressive display in Betta splendens is particularly prominent, and vital to its adaptation to the environment. Methylmercury is an organic variation of Hg that presents particularly pronounced neuro-behavioral effects. The present experiments aim to test the effect of acute and chronic poisoning with methylmercur... | ['Affect', 'Aggression', 'Animals', 'Appetitive Behavior', 'Behavior, Animal', 'Fishes', 'Methylmercury Compounds'] | 17,992,970 | [['F01.470.047'], ['F01.145.126.125', 'F01.145.813.045'], ['B01.050'], ['F01.145.113.111'], ['F01.145.113'], ['B01.050.150.900.493'], ['D02.691.750.100.738']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Overhydration prevalence in peritoneal dialysis - A 2 year longitudinal analysis. | BACKGROUND AND OBJECTIVES: Hypervolemia is a major concern in dialysis patients, and is associated with increased cardiovascular risk and death. Cross sectional analysis have previously demonstrated that peritoneal dialysis (PD) patients are not more overhydrated when compared to haemodialysi? ones. This study was desi... | ['Adult', 'Body Composition', 'Diuresis', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Nutritional Status', 'Peritoneal Dialysis', 'Prevalence', 'Prospective Studies', 'Water-Electrolyte Imbalance'] | 26,300,513 | [['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['G08.852.179'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['M01.060.116.630'], ['G07.203.650.650', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of ultrasound, shortwaves, and physical exertion on pregnancy outcome in physiotherapists. | STUDY OBJECTIVE: The aim of the study was to investigate whether occupational exposure among physiotherapists is associated with spontaneous abortion or congenital malformation in the offspring.DESIGN: The study was a retrospective nested case-control study, where the pregnancy outcome data were based on the medical re... | ['Abortion, Spontaneous', 'Adult', 'Congenital Abnormalities', 'Female', 'Finland', 'Humans', 'Occupational Exposure', 'Physical Exertion', 'Physical Therapy Modalities', 'Pregnancy', 'Pregnancy Outcome', 'Risk Factors', 'Short-Wave Therapy', 'Ultrasonics'] | 2,273,355 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['C16.131'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.600'], ['G11.427.683'], ['E02.779', 'E02.831.535'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['E05.318.740.600.800.725', 'N05.715.350.200... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Ribosomal frameshifting on MJD-1 transcripts with long CAG tracts. | The expanded CAG tract diseases are a heterogeneous group of late-onset neurodegenerative disorders characterized by the accumulation of insoluble protein material and premature neuronal cell death. Recent work has provided support for several mechanisms that may account for neurodegeneration, but no unifying mechanism... | ['Amino Acid Sequence', 'Anisomycin', 'Ataxin-3', 'Cells, Cultured', 'DNA Primers', 'Flow Cytometry', 'Frameshift Mutation', 'Frameshifting, Ribosomal', 'Green Fluorescent Proteins', 'Heredodegenerative Disorders, Nervous System', 'Humans', 'Immunoblotting', 'Immunohistochemistry', 'Molecular Sequence Data', 'Nerve Tis... | 16,087,686 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D03.383.773.050'], ['D08.811.037.250', 'D12.776.631.069.875', 'D12.776.660.075.875'], ['A11.251'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of pulse width of a variable square pulse (VSP) erbium:YAG laser on the treatment outcome of periorbital wrinkles in Asians. | BACKGROUND: Uses of appropriate laser parameters are essential for an optimum outcome with minimal risks of complications.OBJECTIVE: To evaluate the effect of pulse width of a variable square pulse (VSP) Er:YAG laser on the treatment outcome.METHODS: Twenty-four Thais with periorbital wrinkles received two treatments w... | ['Adult', 'Esthetics', 'Female', 'Follow-Up Studies', 'Humans', 'Laser Therapy', 'Lasers, Solid-State', 'Middle Aged', 'Pain, Postoperative', 'Patient Satisfaction', 'Postoperative Care', 'Rejuvenation', 'Risk Assessment', 'Skin Aging', 'Thailand', 'Treatment Outcome'] | 20,465,647 | [['M01.060.116'], ['F02.463.785.477', 'K01.752.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E07.632.490.490', 'E07.710.520.490'], ['M01.060.116.630'], ['C23.550.767.700', 'C23.888.592.612.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hippocampal shape analysis in Alzheimer's disease using functional data analysis. | The hippocampus is one of the first affected regions in Alzheimer's disease. The left hippocampi of control subjects, patients with mild cognitive impairment and patients with Alzheimer's disease are represented by spherical harmonics. Functional data analysis is used in the hippocampal shape analysis. Functional princ... | ['Aged', 'Alzheimer Disease', 'Cognition Disorders', 'Female', 'Hippocampus', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Principal Component Analysis'] | 24,105,806 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['F03.615.250'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E05.318.740.562']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Systemic and mucosal immune responses in mice after mucosal immunization with group B streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate vaccine. | Group B streptococci (GBS) colonize the female genital and rectal tracts and can cause invasive infection in susceptible newborns. An optimally effective GBS vaccine should induce mucosal and systemic immunity. In this study, we investigate the local and systemic immune responses to GBS type III capsular polysaccharide... | ['Animals', 'Antibodies, Bacterial', 'Bacterial Capsules', 'Bacterial Vaccines', 'Cholera Toxin', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Immunity, Mucosal', 'Immunoglobulin A', 'Immunoglobulin G', 'Mice', 'Mucous Membrane', 'Streptococcal Infections', 'Streptococcus agalactiae', 'Vaccination', 'Vaccines, Conju... | 10,992,481 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['A20.186'], ['D20.215.894.135'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vivo dynamics and differential microtubule-binding activities of MAP65 proteins. | Plant cells produce different microtubule arrays that are essential for cell division and morphogenesis without equivalent in other eukaryotes. Microtubule-associated proteins influence the behavior of microtubules that is presumed to culminate into transitions from one array to another. We analyzed the microtubule-bin... | ['Arabidopsis', 'Arabidopsis Proteins', 'Benzamides', 'Gene Expression Regulation, Plant', 'Green Fluorescent Proteins', 'Microscopy, Confocal', 'Microtubule-Associated Proteins', 'Microtubules', 'Mitosis', 'Nitrobenzenes', 'Organothiophosphorus Compounds', 'Plants, Genetically Modified', 'Protein Binding', 'Tobacco', ... | 15,557,096 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['G05.308.375'], ['D12.776.532.265'], ['E01.370.350.515.395', 'E05.595.395'], ['D12.776.220.600.450', 'D12.776.631.560'], ['A11.284.430.214.190.750.602'], ['G04.144.220.220.781', 'G05.11... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats. | Neuropathic pain is a type of chronic pain following central or peripheral nervous system lesions that cause allodynia (pain initiated by a non-painful stimulus) and hyperalgesia (increased pain sensation following a painful stimulus). The first objective of the study was to evaluate the pharmacokinetics of eugenol, th... | ['Algorithms', 'Animals', 'Area Under Curve', 'Clove Oil', 'Eugenol', 'Hyperalgesia', 'Male', 'Metabolic Clearance Rate', 'Neuralgia', 'Rats', 'Rats, Sprague-Dawley', 'Time Factors'] | 17,321,520 | [['G17.035', 'L01.224.050'], ['B01.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D20.215.784.750.186'], ['D02.241.223.200.054.500'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['C10.668.829... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family? | The serum collectin mannan-binding lectin (MBL) binds to oligomannose and GlcNAc-terminating glycans present on microorganisms. Using a commercial affinity chromatography resin containing immobilized MBL we screened human and mouse serum for endogenous MBL-binding targets. We isolated the serum protease inhibitor alpha... | ['Animals', 'Asparagine', 'Chromatography, High Pressure Liquid', 'Complement System Proteins', 'Conserved Sequence', 'Electrophoresis, Polyacrylamide Gel', 'Esters', 'Glycoside Hydrolases', 'Glycosylation', 'Humans', 'Hydrogen-Ion Concentration', 'Lectins', 'Mannose', 'Mannose-Binding Lectin', 'Mass Spectrometry', 'Mi... | 16,407,218 | [['B01.050'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['E05.196.181.400.300'], ['D12.776.124.486.274'], ['G02.111.570.580'], ['E05.196.401.402', 'E05.301.300.319'], ['D02.241.400'], ['D08.811.277.450'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A preliminary risk assessment of potential exposure to naturally occurring estrogens from Beijing (China) market milk products. | This study was conducted to determine the occurrence of the natural steroid hormones estrone (E1), 17á-estradiol (áE2), 17â-estradiol (âE2) and estriol (E3) in 38 commercial milk samples obtained from markets in Beijing, China. Liquid Chromatography coupled with tandem mass spectrometry (LC-MS/MS) was employed to deter... | ['Child', 'Child, Preschool', 'China', 'Chromatography, Liquid', 'Environmental Exposure', 'Estrogens', 'Humans', 'Risk Assessment', 'Tandem Mass Spectrometry'] | 24,910,459 | [['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['E05.196.181.400'], ['N06.850.460.350'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['E05.196.5... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hospital week celebration is potent P.R. tool. | A hospital uses National Hospital Week events to reach out both to the public and to its employees. | ['Anniversaries and Special Events', 'Annual Reports as Topic', 'Disaster Planning', 'Hospital Bed Capacity, 100 to 299', 'Hospitals', 'New Jersey', 'Personnel, Hospital', 'Public Relations', 'Radio'] | 7,364,401 | [['K01.400.095', 'N04.452.822.070'], ['N04.452.070'], ['N06.230.100.035'], ['N02.278.306.472.120'], ['N02.278.421'], ['Z01.107.567.875.500.525'], ['M01.526.485.740', 'N02.360.740'], ['N04.452.822'], ['J01.897.280.500.739', 'L01.178.590.700', 'L01.178.820.090.739', 'L01.178.847.514']] | ['Humanities [K]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase. | Aromatase cytochrome P450 (CYP19) converts androgen to estrogen. In this study, the interactions of four classes of compounds, 17beta-estradiol (the product of aromatase), 17-methyltestosterone (a synthetic androgen), dibenzylfluorescein (a synthetic substrate of aromatase), and coumestrol (a phytoestrogen), with aroma... | ['Animals', 'Aromatase', 'Aromatase Inhibitors', 'CHO Cells', 'Coumestrol', 'Cricetinae', 'Cricetulus', 'Estradiol', 'Fluoresceins', 'Humans', 'Methyltestosterone', 'Models, Molecular', 'Mutagenesis, Site-Directed', 'Recombinant Proteins', 'Structure-Activity Relationship', 'Transfection'] | 18,184,606 | [['B01.050'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['D27.505.519.389.870.300', 'D27.505.696.399.450.327.149', 'D27.505.696.399.450.855.300'], ['A11.251.210.200', 'A11.436.155'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of tolerability and ability to increase immunosuppression in renal transplant patients converted from mycophenolate mofetil to enteric-coated mycophenolate sodium. | BACKGROUND: Dose reductions or discontinuations of mycophenolate mofetil (MMF) result in higher incidences of acute rejection and graft loss. Converting renal transplant patients experiencing MMF-related gastrointestinal (GI) side effects to equimolar enteric-coated mycophenolate sodium (EC-MPS) may relieve GI symptoms... | ['Adult', 'Aged', 'Cyclosporine', 'Dose-Response Relationship, Drug', 'Drug Tolerance', 'Female', 'Gastrointestinal Diseases', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Mycophenolic Acid', 'Prospective Studies', 'Safety', 'Tablets, Enteric-Coated', 'Tacrolimus'] | 19,917,367 | [['M01.060.116'], ['M01.060.116.100'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.992'], ['C06.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['D02.241... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
GPU-based minimum variance beamformer for synthetic aperture imaging of the eye. | Minimum variance (MV) beamforming has emerged as an adaptive apodization approach to bolster the quality of images generated from synthetic aperture ultrasound imaging methods that are based on unfocused transmission principles. In this article, we describe a new high-speed, pixel-based MV beamforming framework for syn... | ['Animals', 'Computer Graphics', 'Computer Simulation', 'Equipment Design', 'Eye', 'Feasibility Studies', 'Image Enhancement', 'Image Processing, Computer-Assisted', 'Signal Processing, Computer-Assisted', 'Swine', 'Ultrasonography'] | 25,638,315 | [['B01.050'], ['L01.224.108', 'L01.296.110'], ['L01.224.160'], ['E05.320'], ['A01.456.505.420', 'A09.371'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.350.600.350', 'L01.224.308.380'], ['L01.224.308'], ['L01.224.800'], ['B01.050.150.900.649.313.500.880'], ['E01.370.350.8... | ['Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Visual field defect classification in the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Registry Study. | PURPOSE: To describe a new combined myopia and glaucoma visual field classification system in order to report the visual field defects in a population of mostly young Chinese high myopes aged 7-70 years.METHODS: A total of 1434 visual fields (including confirmatory repeats of abnormal defects) from 487 high myopes (sph... | ['Adolescent', 'Adult', 'Aged', 'Child', 'China', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Myopia', 'Optic Disk', 'Prospective Studies', 'Refraction, Ocular', 'Registries', 'Scotoma', 'Time Factors', 'Visual Field Tests', 'Visual Fields', 'Young Adult'] | 27,033,693 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['Z01.252.474.164'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C11.744.636'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Risk-sensitive foraging and the evolution of cooperative breeding and reproductive skew. | BACKGROUND: Group formation and food sharing in animals may reduce variance in resource supply to breeding individuals. For some species it has thus been interpreted as a mechanism of risk avoidance. However, in many groups reproduction is extremely skewed. In such groups resources are not shared equally among the memb... | ['Animals', 'Biological Evolution', 'Breeding', 'Cooperative Behavior', 'Food Chain', 'Models, Biological'] | 18,366,668 | [['B01.050'], ['G05.045', 'G16.075'], ['E05.820.150', 'G05.090'], ['F01.145.813.115'], ['G16.500.275.157.250', 'N06.230.124.250'], ['E05.599.395']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Investigating changes in mortality attributable to heat and cold in Stockholm, Sweden. | Projections of temperature-related mortality rely upon exposure-response relationships using recent data. Analyzing long historical data and trends may extend knowledge of past and present impacts that may provide additional insight and improve future scenarios. We collected daily mean temperatures and daily all-cause ... | ['Cold Temperature', 'Forecasting', 'Hot Temperature', 'Humans', 'Mortality', 'Sweden', 'Temperature'] | 29,748,912 | [['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['I01.320'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.40... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Role of the insular cortex in the modulation of baroreflex sensitivity. | Cervical vagal stimulation for 2 h results in a depressed baroreflex sensitivity produced by an enhanced sympathetic output, as indicated by increased plasma norepinephrine levels. The current study examined the role of the insular cortex in modulating the vagal stimulation-induced changes in baroreflex sensitivity. Ma... | ['Anesthetics, Local', 'Animals', 'Baroreflex', 'Cerebral Cortex', 'Lidocaine', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Stimulation, Chemical', 'Sympathetic Nervous System', 'Vagus Nerve'] | 9,612,410 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['G09.330.380.057', 'G11.561.731.063'], ['A08.186.211.200.885.287.500'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fas and Fas ligand expression in fetal and adult human testis with normal or deranged spermatogenesis. | In mice, the Fas/Fas ligand (FasL) system has been shown to be involved in germ cell apoptosis. In the present study we evaluated the expression of Fas and Fas ligand (FasL) in fetal and adult human testis. Semiquantitative RT-PCR demonstrated the expression of Fas and FasL messenger ribonucleic acids in adult testis, ... | ['Abortion, Therapeutic', 'Adult', 'Animals', 'Apoptosis', 'Fas Ligand Protein', 'Fetus', 'Gestational Age', 'Humans', 'Leydig Cells', 'Male', 'Membrane Glycoproteins', 'Mice', 'Middle Aged', 'Oligospermia', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sertoli Cells', 'Spermatogenesis', 'Testis', 'Transcription,... | 10,946,867 | [['E04.520.050.060'], ['M01.060.116'], ['B01.050'], ['G04.146.954.035'], ['D12.644.276.374.750.249', 'D12.776.395.550.312', 'D12.776.467.374.750.249', 'D12.776.543.550.312', 'D23.529.374.750.249'], ['A16.378'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.444.84... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Outcome of newborn with birth weight less than or equal to 1500g and gestational age less than or equal to 32 weeks, during the 2 first years of age corrected: comparison of two time periods]. | INTRODUCTION: Advances in perinatal care have resulted in increased survival rates for extremely low birth weight children, but it is fundamental to know if these improved survival rates have been accompanied by increased impairment rates.OBJECTIVE: To compare, over two different time periods, the survival and disabili... | ['Age Factors', 'Follow-Up Studies', 'Gestational Age', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Infant, Very Low Birth Weight', 'Time Factors'] | 20,435,533 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614'], ['M01.060.703.520.460.600'], ['G01.910.857']... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential fibrinolytic properties of the recombinant plasminogen activator BM 06.022 in human plasma and blood clot systems in vitro. | The effects of the unglycosylated recombinant plasminogen activator BM 06.022, consisting of the kringle 2 and protease domains of tissue-type plasminogen activator (t-PA), on clot lysis were evaluated in an in vitro system. Fresh and aged 125I-labelled human platelet-poor (PPP) and platelet-rich plasma (PRP) and whole... | ['Evaluation Studies as Topic', 'Fibrinolysis', 'Humans', 'In Vitro Techniques', 'Peptide Fragments', 'Plasma', 'Plasminogen Activators', 'Recombinant Proteins', 'Tissue Plasminogen Activator', 'Urokinase-Type Plasminogen Activator'] | 8,388,740 | [['E05.337', 'N05.715.360.335'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D12.644.541'], ['A12.207.152.693', 'A12.207.270.695', 'A15.145.693'], ['D08.811.277.656.300.760.635', 'D08.811.277.656.959.350.635', 'D12.776.124.125.662'], ['D12.776.828'], ['D08.811.277.656.300.76... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ontogeny of the hypothalamo-neurohypophysial system in rats--an immunohistochemical study. | In fetal rats neurophysin has been visualized immunohistochemically first at the 16th gestation day in perikaryons of the supraoptic nucleus, followed by the median eminence and the neurohypophysis at the 17th day, and the paraventricular neurons at the 19th day. The external zone of the median eminence contains abunda... | ['Aging', 'Animals', 'Animals, Newborn', 'Female', 'Hypothalamo-Hypophyseal System', 'Immunoenzyme Techniques', 'Pregnancy', 'Rats'] | 334,523 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['A06.688.357', 'A08.186.211.180.497.352.435', 'A08.186.211.200.317.357.352.435', 'A08.713.357'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comparative study: use of a Brain-computer Interface (BCI) device by people with cerebral palsy in interaction with computers. | This article presents a comparative study among people with cerebral palsy and healthy controls, of various ages, using a Brain-computer Interface (BCI) device. The research is qualitative in its approach. Researchers worked with Observational Case Studies. People with cerebral palsy and healthy controls were evaluated... | ['Brain-Computer Interfaces', 'Brazil', 'Case-Control Studies', 'Cerebral Palsy', 'Humans', 'Portugal', 'Reaction Time', 'User-Computer Interface'] | 26,536,851 | [['E07.305.076'], ['Z01.107.757.176'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C10.228.140.140.254'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.727'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['L01.224.900.910']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Septic cavernous sinus thrombosis with bilateral secondary orbital infection. | Cavernous sinus thrombosis may occur as a secondary threatening condition to spread from local or distant foci of infection. We report a case where secondary retrograde spread occurred to both the ipsilateral and contralateral orbits with very different clinical manifestations. To our knowledge such spread is unreporte... | ['Adult', 'Anti-Infective Agents', 'Anticoagulants', 'Cavernous Sinus Thrombosis', 'Combined Modality Therapy', 'Diagnosis, Differential', 'Humans', 'Male', 'Orbital Diseases', 'Streptococcal Infections', 'Streptococcus constellatus', 'Visual Acuity'] | 17,613,858 | [['M01.060.116'], ['D27.505.954.122'], ['D27.505.954.502.119'], ['C10.228.140.300.525.425.500.375', 'C14.907.253.566.350.500.375', 'C14.907.355.590.213.350.500.375'], ['E02.186'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.675'], ['C01.150.252.410.890'], ['B03.353.750.737.872.875.475.150', 'B03... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genotyping of chimerical BCR-ABL1 RNA in chronic myeloid leukemia by integrated DNA chip. | Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) are associated with fusion of the BCR and ABL1 genes by chromosome translocation. The chimerical BCR-ABL1 gene encodes different fusion proteins that vary in size, depending on the breakpoint in the BCR re... | ['Cell Line, Tumor', 'Fusion Proteins, bcr-abl', 'Gene Order', 'Genotype', 'Humans', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Oligonucleotide Array Sequence Analysis', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 22,749,885 | [['A11.251.210.190', 'A11.251.860.180'], ['D08.811.913.696.620.682.725.500.500', 'D12.776.602.500.500.100', 'D12.776.624.664.500.100', 'D12.776.624.664.700.171.500'], ['G05.340'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.250', 'C15.378.190.636.370'], ['E05.393.661.640', 'E05.393.7... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Survey of cardiac pacing in Canada. | UNLABELLED: The status of cardiac pacing in Canada in 1989 was determined from data provided by 62 of 128 physicians surveyed (48% response) and four major manufacturer/distributors. A questionnaire designed for the IXth World Symposium on Cardiac Pacing was used.DEMOGRAPHICS: There were five implant hospitals per mill... | ['Arrhythmias, Cardiac', 'Attitude of Health Personnel', 'Canada', 'Cardiac Pacing, Artificial', 'Data Collection', 'Humans', 'Middle Aged', 'Pacemaker, Artificial', "Practice Patterns, Physicians'"] | 1,756,418 | [['C14.280.067', 'C23.550.073'], ['F01.100.050', 'N05.300.100'], ['Z01.107.567.176'], ['E02.331.200'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E07.305.250.750'], ['N04.590.374.577', 'N05.300.625']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The negative interaction between the degradation of phenanthrene and tricyclazole in medium, soil and soil/compost mixture. | To assess the co-catabolism of phenanthrene and tricyclazole in different samples, the interaction during the degradation of phenanthrene and tricyclazole were investigated in medium, soil and soil/spent mushroom compost (SMC) mixture. Generally, tricyclazole showed a negative influence on the activity of phenanthrene ... | ['Phenanthrenes', 'Soil', 'Soil Microbiology', 'Sphingomonas', 'Thiazoles'] | 18,189,158 | [['D02.455.426.559.847.723', 'D04.615.723'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['B03.440.400.425.750', 'B03.660.050.800.750'], ['D02.886.675', 'D03.383.129.708']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of Florida's Personal Fitness Course on cognitive, attitudinal and physical fitness measures of secondary students: a pilot study. | The effects of Florida's Personal Fitness Course were studied on 60 secondary students' cognitive achievement, physical fitness, and attitude toward physical activity. Significant improvement in knowledge of fitness concepts, selected physical fitness parameters, and over-all attitude toward participation in physical a... | ['Adolescent', 'Attitude', 'Cognition', 'Florida', 'Humans', 'Physical Education and Training', 'Physical Fitness', 'Pilot Projects'] | 3,503,265 | [['M01.060.057'], ['F01.100'], ['F02.463.188'], ['Z01.107.567.875.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.233.543'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Natural killer cells inhibit outgrowth of autologous Epstein-Barr virus-infected B lymphocytes. | To determine whether natural killer (NK) cells are the cells responsible for inhibition of outgrowth of Epstein-Barr virus (EBV)-infected autologous B lymphocytes, NK-enriched or NK-depleted populations were prepared by Percoll density gradient fractionation and complement lysis depletion of cells reacting with NK-spec... | ['Adult', 'Antibodies, Monoclonal', 'B-Lymphocytes', 'Cell Division', 'Cell Separation', 'Complement System Proteins', 'Cytotoxicity, Immunologic', 'Herpesvirus 4, Human', 'Humans', 'In Vitro Techniques', 'Killer Cells, Natural', 'T-Lymphocytes, Cytotoxic'] | 2,993,873 | [['M01.060.116'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E01.370.22... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of railroad tank car releases using a generalized binomial model. | The United States is experiencing an unprecedented boom in shale oil production, leading to a dramatic growth in petroleum crude oil traffic by rail. In 2014, U.S. railroads carried over 500,000 tank carloads of petroleum crude oil, up from 9500 in 2008 (a 5300% increase). In light of continual growth in crude oil by r... | ['Accidents', 'Humans', 'Models, Statistical', 'Petroleum', 'Railroads', 'Risk Factors', 'Risk Management', 'Safety', 'Transportation', 'United States'] | 26,298,272 | [['N06.850.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['D20.345.630', 'N06.230.132.258.630'], ['J01.937.690'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Clinical and imaging features associated with intracranial internal carotid artery calcifications in patients with ischemic stroke. | INTRODUCTION: Intracranial internal carotid artery calcifications (ICAC), a frequent finding on imaging studies, are predictive of future stroke risk in population-based studies. The clinical significance of this observation among ischemic stroke patients is however less clear. In this study, we analyzed ICAC burden in... | ['Adult', 'Aged', 'Aged, 80 and over', 'Angiography', 'Brain Ischemia', 'Carotid Artery Diseases', 'Carotid Artery, Internal', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Risk Factors', 'Stroke', 'Tomography, X-Ray Computed', 'Vascular Calcification'] | 25,633,540 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.200', 'C14.907.253.123'], ['A07.015.114.186.200.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High levels of molecular polymorphism at the KIR2DL4 locus in French and Congolese populations: impact for anthropology and clinical studies. | To characterize KIR2DL4 molecular polymorphism, a cloning-sequencing protocol was performed in 49 French and 52 Teke Congolese individuals. These two populations exhibited high levels of genetic diversity for KIR2DL4, possibly under the influence of natural selection. The most frequent alleles in French individuals (i.... | ['Alleles', 'Congo', 'France', 'Gene Duplication', 'Genetics, Population', 'Humans', 'Polymorphism, Genetic', 'Receptors, KIR2DL4'] | 19,679,155 | [['G05.360.340.024.340.030'], ['Z01.058.290.100.140'], ['Z01.542.286'], ['G05.365.590.320', 'G05.558.320'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795'], ['D12.776.543.750.705.895.500.468']] | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
The role of hypothalamic glutathione in hypertensive animals. | The role of brain glutathione metabolism in hypertensive animals was studied. In spontaneously hypertensive rats (SHR) from prehypertension to established hypertension, the content of oxidized glutathione (GSSG) and the ratio of GSSG to GSH in the hypothalamus were significantly (p less than 0.05) higher than those in ... | ['Animals', 'Blood Pressure', 'Glutathione', 'Hypertension', 'Hypothalamus', 'Male', 'Oxidation-Reduction', 'Rats', 'Rats, Inbred Strains', 'Rats, Inbred WKY'] | 3,243,001 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.644.456.448'], ['C14.907.489'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['G02.700', 'G03.295.531'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['B01.050.050.199.520.7... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SQUARE--determining reliable regions in sequence alignments. | The Server for Quick Alignment Reliability Evaluation (SQUARE) is a Web-based version of the method we developed to predict regions of reliably aligned residues in sequence alignments. Given an alignment between a query sequence and a sequence of known structure, SQUARE is able to predict which residues are reliably al... | ['Algorithms', 'Databases, Protein', 'Information Storage and Retrieval', 'Internet', 'Proteins', 'Sequence Alignment', 'Sequence Analysis, Protein', 'Software'] | 14,764,569 | [['G17.035', 'L01.224.050'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.230.110.500'], ['D12.776'], ['E05.393.751'], ['E05.393.760.705'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Color Doppler ultrasonography percutaneous transluminal angioplasty of vascular access grafts. | Percutaneous transluminal angioplasty (PTA) is a possible treatment for stenosis. This study aimed to verify the impact of a vascular access (VA) surveillance protocol, based on the detection of functional changes and their correction by a new PTA method for VA performed under color Doppler ultrasonography (CDU) guidan... | ['Aged', 'Angioplasty, Balloon', 'Arteriovenous Shunt, Surgical', 'Blood Vessel Prosthesis Implantation', 'Follow-Up Studies', 'Graft Occlusion, Vascular', 'Humans', 'Kaplan-Meier Estimate', 'Middle Aged', 'Proportional Hazards Models', 'Prospective Studies', 'Renal Dialysis', 'Retrospective Studies', 'Risk Assessment'... | 17,534,792 | [['M01.060.116.100'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['E04.035.087', 'E04.100.814.868.249'], ['E04.100.814.868.500', 'E04.650.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.550.767.400'], ['B01.050.150.90... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Biochemical blood indices of patients with a myocardial infarct complicated by heart rupture]. | Adrenal function, blood kallikrein-kinin status and the levels of serotonin, histamine, electrolytes and enzymes were repeatedly assessed in 97 patients with myocardial infarction and external cardiorrhexis. Certain patterns were identified as common to the pre-rupture period and the time of the rupture proper that can... | ['Adrenal Cortex Function Tests', 'Death, Sudden', 'Heart Rupture', 'Heart Rupture, Post-Infarction', 'Humans', 'Myocardial Infarction', 'Shock, Cardiogenic', 'Time Factors'] | 3,761,851 | [['E01.370.374.050'], ['C23.550.260.322'], ['C14.280.470'], ['C14.280.470.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C14.280.647.500.750', 'C14.907.585.500.750', 'C23.550.513.355.750.750', 'C23.550.717.489.750.750', 'C2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Duplication (20p) in association with thyroid carcinoma. | We report on a girl with short stature, mental retardation, mutism, "coarse" facial appearance, and papillary-follicular thyroid carcinoma. She had dup(20p) derived from a paternal balanced translocation [(12p;20p)]. We speculate that the carcinoma in our patient may be related to the deletion of material from 12p resu... | ['Adenocarcinoma', 'Adolescent', 'Chromosome Aberrations', 'Chromosome Disorders', 'Chromosomes, Human, Pair 12', 'Chromosomes, Human, Pair 20', 'Female', 'Humans', 'Intellectual Disability', 'Multigene Family', 'Thyroid Neoplasms', 'Translocation, Genetic'] | 8,418,651 | [['C04.557.470.200.025'], ['M01.060.057'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['A11.284.187.520.300.325.360', 'G05.360.162.520.300.325.360'], ['A11.284.187.520.300.460.470', 'G05.360.162.520.300.460.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Image analysis of effects of 4 drugs on coronary occlusion and myocardial reperfusion injury]. | Myocardial infarction induced by coronary occlusion (O model) and reperfusion (R model) and the effects of nitroglycerin (Nit), propranolol (Pro), lidocaine (Lid), nifedipine (Nif), and saline were studied in rats by image analysis and weighing methods. The results showed that the myocardial infarct size (MIS) in R and... | ['Animals', 'Female', 'Image Processing, Computer-Assisted', 'Male', 'Myocardial Infarction', 'Myocardial Reperfusion Injury', 'Myocardium', 'Nifedipine', 'Nitroglycerin', 'Organ Size', 'Propranolol', 'Rats', 'Rats, Wistar'] | 8,249,633 | [['B01.050'], ['L01.224.308'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.877.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D03.383.725.203.540'], ['D02.640.636'], ['E01.370... | ['Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Incidence of injury in elite junior Rugby Union: a prospective descriptive study. | The high incidence of injury in Rugby Union is well documented, particularly at elite levels of competition. This article describes the incidence and nature of all injuries sustained by elite Western Australian junior Rugby Union players during the 26 weeks up to and including the 1997 National Championship campaign. I... | ['Adolescent', 'Athletic Injuries', 'Causality', 'Football', 'Humans', 'Incidence', 'Prospective Studies', 'Western Australia'] | 15,712,499 | [['M01.060.057'], ['C26.115'], ['N05.715.350.200', 'N06.850.490.625'], ['I03.450.642.845.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Reproducibility of intra-operative measurement of the mechanical axes of the lower limb during total knee replacement with a non-image-based navigation system. | OBJECTIVE: The restoration of a normal mechanical axis of the lower limb following total knee prosthesis (TKP) depends on the accuracy of the intra-operative measurement of the femoro-tibial angle. We have studied the reproducibility of intra-operative measurement of the coronal mechanical femoro-tibial axis with the O... | ['Arthroplasty, Replacement, Knee', 'Computer Simulation', 'Humans', 'Knee Prosthesis', 'Leg', 'Monitoring, Intraoperative', 'Reproducibility of Results'] | 16,192,056 | [['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400.410'], ['A01.378.610.500'], ['E01.370.520.510', 'E04.510'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Vascular contractile properties in hypertension. I. A study of testing methods. | Abnormal contractile responses of blood vessels are observed widely in several hypertension models and are assumed to play a role in the etiology of essential hypertension. Inconsistent reports also exist due to different animals, preparations, and experimental techniques employed. In this investigation, we compared va... | ['Animals', 'Aorta, Thoracic', 'Hypertension', 'Methods', 'Norepinephrine', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Vasoconstriction'] | 8,287,717 | [['B01.050'], ['A07.015.114.056.372'], ['C14.907.489'], ['E05.581'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.830'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.900.649.313.992.635.505.700.400.300'... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxic effects of supplemental copper and roxarsone when fed alone or in combination to young pigs. | Three experiments were conducted to investigate the roxarsone (3-nitro-4-hydroxyphenylarsonic acid) X copper (Cu) interaction in weanling pigs. Supplemental roxarsone at 400 mg/kg diet decreased rate and efficiency of weight gain and caused visible neurological signs of toxicosis. Copper addition (CuSO4 X 5H2O) at a le... | ['Animals', 'Arsenic Poisoning', 'Bile', 'Body Weight', 'Copper', 'Drug Interactions', 'Liver', 'Roxarsone', 'Swine'] | 3,759,688 | [['B01.050'], ['C10.720.475.150', 'C25.723.098'], ['A12.200.087'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G07.690.773.968'], ['A03.620'], ['D02.129.700'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extracellularly applied ruthenium red and cADP ribose elevate cytosolic Ca2+ in isolated rat osteoclasts. | We demonstrated recently that the divalent cation-sensing receptor on the osteoclast, the Ca2+ receptor (CaR), is a functional component of a cell surface-expressed ryanodine receptor-like molecule (RyR). The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-... | ['Adenosine Diphosphate Ribose', 'Animals', 'Calcium', 'Cells, Cultured', 'Coloring Agents', 'Osteoclasts', 'Rats', 'Rats, Wistar', 'Ruthenium Red'] | 8,780,250 | [['D03.633.100.759.646.138.124.070.125', 'D09.408.620.569.070.125', 'D13.695.667.138.124.070.125', 'D13.695.827.068.124.070.125', 'D13.695.827.708.070.125'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D27.720.233'], ['A11.329.372.700', 'A11.627.482.700'], ['B01.050.150.900.649.31... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Speckle tracking echocardiography in mature Irish Wolfhound dogs: technical feasibility, measurement error and reference intervals. | BACKGROUND: Two-dimensional strain measurements obtained by speckle tracking echocardiography (STE) have been reported in both humans and dogs. Incorporation of this technique into canine clinical practice requires the availability of measurements from clinically normal dogs, ideally of the same breed, taken under norm... | ['Animals', 'Biomechanical Phenomena', 'Dogs', 'Echocardiography', 'Female', 'Heart', 'Male', 'Reference Values'] | 23,680,023 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541'], ['E05.978.810']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of different hemopoietic microenvironment on the differentiation of hemopoietic cells from human embryonic stem cells]. | OBJECTIVE: To observe the inductive efficiency of deriving hematopoietic cells from human embryonic stem (hES) cells co-cultured with human yolk sac stromal cells, fetal liver stromal cells or fetal bone marrow stromal cells,in order to discuss the effect of the different hemopoietic microenvironment on hemopoietic cyt... | ['Antigens, CD34', 'Cell Differentiation', 'Cells, Cultured', 'Cellular Microenvironment', 'Coculture Techniques', 'Embryonic Stem Cells', 'Fetus', 'Hematopoietic Stem Cells', 'Humans', 'Leukocyte Common Antigens', 'Mesenchymal Stem Cells', 'Stromal Cells', 'Yolk Sac'] | 18,182,715 | [['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['G04.152'], ['A11.251'], ['G04.366'], ['E05.481.500.374'], ['A11.872.700.250'], ['A16.378'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.352.650.775.400.100.500', 'D12.644.360.587.100.500', 'D12.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative Fundus Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is not Increased in Non-Lesion Areas of Retina. | Since the lipofuscin of retinal pigment epithelial (RPE) cells has been implicated in the pathogenesis of Best vitelliform macular dystrophy, we quantified fundus autofluorescence (quantitative fundus autofluorescence, qAF) as an indirect measure of RPE lipofuscin levels. Mean non-lesion qAF was found to be within norm... | ['Bestrophins', 'Chloride Channels', 'Eye Proteins', 'Fluorescence', 'Fundus Oculi', 'Genetic Predisposition to Disease', 'Humans', 'Lipofuscin', 'Microscopy, Confocal', 'Mutation', 'Ophthalmoscopy', 'Retinal Pigment Epithelium', 'Tomography, Optical Coherence', 'Vitelliform Macular Dystrophy'] | 26,427,423 | [['D12.776.157.530.400.175.063', 'D12.776.306.228', 'D12.776.543.550.450.175.063', 'D12.776.543.585.400.175.063'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['D12.776.306'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['A09.371.729.313'], ['C23.550.291.687.500', 'G05... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
What makes counting count? Verbal and visuo-spatial contributions to typical and atypical number development. | Williams Syndrome (WS) is marked by a relative strength in verbal cognition coupled with a serious impairment in non-verbal cognition. A strong deficit in numerical cognition has been anecdotally reported in this disorder; however, its nature has not been systematically investigated. Here, we tested 14 children with WS... | ['Child', 'Cognition Disorders', 'Female', 'Humans', 'Male', 'Mathematics', 'Neuropsychological Tests', 'Nonverbal Communication', 'Severity of Illness Index', 'Space Perception', 'Verbal Behavior', 'Visual Perception', 'Williams Syndrome'] | 12,742,762 | [['M01.060.406'], ['F03.615.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['F04.711.513'], ['F01.145.209.530', 'L01.143.649'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['F02.463.593.778'], ['F01.145.209.908'], ['F02.463.593... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. | The generalized seizures of status epilepticus (SE) trigger a series of molecular and cellular events that produce cognitive deficits and can culminate in the development of epilepsy. Known early events include opening of the blood-brain barrier (BBB) and astrocytosis accompanied by activation of brain microglia. Where... | ['Animals', 'Blood-Brain Barrier', 'Chemokine CCL2', 'Encephalitis', 'Gliosis', 'Immunity, Innate', 'Interleukin-1beta', 'Mice', 'Mice, Knockout', 'Monocytes', 'Neurons', 'Receptors, CCR2', 'Seizures', 'Status Epilepticus'] | 27,601,660 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['C10.228.140.430'], ['C23.550.369'], ['G12.450.564'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600',... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation. | Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic cell-restricted member of the Ste20 kinases that acts as a negative regulator of T cell functions through the AP-1, NFAT, and NFkappaB pathways. Using HPK1-deficient (HPK1(-/-)) mice, we report in this study a novel role for HPK1 in dendritic cells (DCs). Spec... | ['Animals', 'Antigen Presentation', 'Apoptosis', 'Bone Marrow Cells', 'Carcinoma, Lewis Lung', 'Cell Differentiation', 'Cytokines', 'Dendritic Cells', 'Enzyme-Linked Immunosorbent Assay', 'Flow Cytometry', 'Lymphocyte Activation', 'Lymphocyte Culture Test, Mixed', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Protei... | 19,414,772 | [['B01.050'], ['G12.119', 'G12.450.050.400.070'], ['G04.146.954.035'], ['A11.148', 'A15.378.316'], ['C04.557.470.200.280', 'C04.619.230'], ['G04.152'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E05.478.566.350.170', 'E05.478.566.380.36... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of mutations on the detection of translational signals based on a communications theory approach. | Gene and regulatory sequence identification is the first step in the functional annotation of any genome. Identification and annotation of such elements in the genome is a fundamental challenge in genomics and computational biology. Since regulatory elements are often short and variable, their identification and discov... | ['Algorithms', 'Computational Biology', 'Computer Communication Networks', 'Escherichia coli', 'Gene Regulatory Networks', 'Genome, Bacterial', 'Models, Statistical', 'Mutation', 'Protein Biosynthesis', 'RNA, Messenger', 'RNA, Ribosomal, 16S', 'Regulatory Elements, Transcriptional', 'Ribosomes', 'Sequence Alignment', '... | 19,963,598 | [['G17.035', 'L01.224.050'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.230.110'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.080.689.360'], ['G05.360.340.358.207'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G05.365.590'], ['G02.111.660.871', 'G03.734.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Functional gene expression analysis of tissue-specific isoforms of Mef2c. | Mef2c contains three alternative exons and generates six Mef2c isoforms in mice. Mef2c á1â isoforms are expressed in neuronal tissues, á2 isoforms are expressed in muscle, and á1 isoforms are expressed in many other tissues. The ã region inclusion and skipped isoforms are present in equal amounts in many tissues. In th... | ['Animals', 'Cells, Cultured', 'Cluster Analysis', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Genes, Reporter', 'Luciferases', 'MEF2 Transcription Factors', 'Mice', 'Microarray Analysis', 'Myogenic Regulatory Factors', 'Organ Specificity', 'Protein Isoforms', 'Tissue Distribution', 'Transfection', 'Val... | 21,842,419 | [['B01.050'], ['A11.251'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['G05.308'], ['G05.360.340.024.340.435'], ['D08.811.682.517', 'D12.776.532.510'], ['D12.776.210.500.570.294', 'D12.776.260.103.750.294', 'D12.776.260.400.249.624', 'D12.776.930.125.750.294', 'D12.776.930.397.7... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Functional cortical effects of novel allelic variants of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) in humans. | INTRODUCTION: Genetic variations of the serotonin transporter-linked polymorphic region (5-HTTLPR) have been implicated in the pathogenesis of several psychiatric disorders. Recent evidence indicates that the biallelic polymorphic region (S and L allele) contains additional variations affecting the mRNA expression.METH... | ['Adult', 'Alleles', 'Cerebral Cortex', 'DNA', 'Evoked Potentials, Auditory', 'Female', 'Genetic Variation', 'Genotype', 'Humans', 'Male', 'Polymorphism, Genetic', 'RNA, Messenger', 'Serotonin', 'Serotonin Plasma Membrane Transport Proteins', 'Synaptic Transmission'] | 17,874,349 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['A08.186.211.200.885.287.500'], ['D13.444.308'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795'], ['D13.444.735.544'], ['D02.092.211.215.801.852', 'D03.633.100.473.91... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Benign osteoblastoma of the temporal bone: Case report and review of the literature. | BACKGROUND: Benign osteoblastoma arising from the temporal bone is extremely rare in elderly patients. We reviewed the literature on benign osteoblastoma of the temporal bone and now propose a new classification of this pathologic entity based on its anatomical location in the temporal bone.CASE DESCRIPTION: A 68-year-... | ['Aged', 'Bone Neoplasms', 'Embolization, Therapeutic', 'Female', 'Fluorodeoxyglucose F18', 'Hearing Loss', 'Humans', 'Intraoperative Complications', 'Neoplasm, Residual', 'Neuronavigation', 'Neurosurgical Procedures', 'Osteoblastoma', 'Positron-Emission Tomography', 'Postoperative Hemorrhage', 'Radiography', 'Temporal... | 17,084,206 | [['M01.060.116.100'], ['C04.588.149', 'C05.116.231'], ['E02.520.360', 'E02.926.500'], ['D09.254.229.500'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['C04.697.700', 'C23.550.727.700'], ['E04.525.800.324', 'E04.749.250', 'E05.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro lymphoproliferative responses to malaria antigens: a prospective study of residents of a holoendemic area with perennial malaria transmission. | A longitudinal, prospective study to examine the relationship between the outcome of infection with Plasmodium falciparum parasites and in vitro T-cell proliferative responses to a P. falciparum schizont extract (PfSE) was conducted in a village in south-eastern Gabon, an area where malaria is holoendemic and transmiss... | ['Adolescent', 'Animals', 'Antigen-Presenting Cells', 'Antigens, Protozoan', 'CD4-Positive T-Lymphocytes', 'Child', 'Child, Preschool', 'Gabon', 'Humans', 'Longitudinal Studies', 'Lymphocyte Activation', 'Malaria, Falciparum', 'Plasmodium falciparum', 'Prospective Studies', 'T-Lymphocytes'] | 8,094,548 | [['M01.060.057'], ['B01.050'], ['A11.066', 'A15.382.066'], ['D23.050.293'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.058.290.100.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Spontaneous rupture of EPL and ECRB tendons in a washerwoman: an unusual phenomenon. | Spontaneous rupture of the extensor pollicis longus (EPL) tendon is rare, and spontaneous non-traumatic rupture of both extensor pollicis longus (EPL) and extensor carpi radialis brevis (ECRB) tendons is not reported in literature. Rupture of EPL is usually associated with rheumatoid arthritis, systemic or local steroi... | ['Female', 'Humans', 'Rupture', 'Rupture, Spontaneous', 'Tendon Injuries', 'Wrist'] | 24,875,511 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.761'], ['C23.300.909'], ['C26.874'], ['A01.378.800.875']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis via caspase-3 activation. | AIM: To investigate the effects of IH764-3 on HSC apoptosis and the expression of caspase-3 protein in HSC apoptotic process.METHODS: HSCs were cultured in medium with different IH764-3 doses(10 microg.mL(-1) 20 microg.mL(-1) 30 microg.mL(-1) 40 microg.mL(-1)) and without IH764-3 and HSC proliferation was quantitativel... | ['Animals', 'Apoptosis', 'Caspase 3', 'Caspases', 'Cell Division', 'Cell Line', 'Drugs, Chinese Herbal', 'Enzyme Activation', 'Hepatocytes', 'Liver Cirrhosis', 'Phytotherapy', 'Rats', 'Salvia miltiorrhiza'] | 12,046,082 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['G04.144.220', 'G04.161.750.500'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An approach for practical multiobjective IMRT treatment planning. | PURPOSE: To introduce and demonstrate a practical multiobjective treatment planning procedure for intensity-modulated radiation therapy (IMRT) planning.METHODS AND MATERIALS: The creation of a database of Pareto optimal treatment plans proceeds in two steps. The first step solves an optimization problem that finds a si... | ['Aged', 'Algorithms', 'Brain Neoplasms', 'Carcinoma, Non-Small-Cell Lung', 'Databases, Factual', 'Female', 'Hemangiopericytoma', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Adjuvant', 'Radiotherapy, Intensit... | 17,920,782 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C04.557.645.380'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Subjective versus objective behavioral ratings following two analogue tasks: a comparison of socially phobic and non-anxious adolescents. | Although results regarding objective social skills deficits in adults are inconsistent, research with youth have consistently demonstrated such deficits. Furthermore, research has consistently demonstrated subjective appraisal of social skill deficit in both youth and adults with social phobia or social anxiety. As a r... | ['Adolescent', 'Adolescent Behavior', 'Anxiety', 'Female', 'Humans', 'Male', 'Observation', 'Phobic Disorders', 'Role Playing', 'Severity of Illness Index', 'Social Behavior', 'Verbal Behavior'] | 16,697,550 | [['M01.060.057'], ['F01.145.022'], ['F01.470.132'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581.249'], ['F03.080.725'], ['E02.190.525.781.653', 'F04.754.864.581.679.653'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['F01.145.813'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Validation of the Korean version of the Bayer activities of daily living scale. | The Bayer-activities of daily living (B-ADL) is a brief and internationally applicable ADL instrument which has been validated in three European countries. The B-ADL has been developed to provide a tool for the assessment of functional deficits in performance of every day tasks as they are observed in mild to moderate ... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Cross-Cultural Comparison', 'Dementia, Vascular', 'Female', 'Humans', 'Korea', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Psychometrics', 'Reproducibility of Results'] | 12,923,826 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['C10.228.140.300.400', 'C10.228.140.300.510.800.500', 'C10.228.140.380.230', 'C10.228.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator. | The cystic fibrosis transmembrane conductance regulator (CFTR) contains multiple membrane spanning sequences that form a Cl- channel pore and cytosolic domains that control the opening and closing of the channel. The fourth intracellular loop (ICL4), which connects the tenth and eleventh transmembrane spans, has a prim... | ['Amino Acid Sequence', 'Chloride Channels', 'Cystic Fibrosis Transmembrane Conductance Regulator', 'HeLa Cells', 'Humans', 'Ion Channel Gating', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Structure-Activity Relationship'] | 8,702,904 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['D12.776.157.530.100.304.500', 'D12.776.157.530.400.175.125', 'D12.776.157.530.450.074.500.500.500.500', 'D12.776.543.550.450.175.125', 'D12.776.543.585.100.304.500', 'D12.776.543.585.400.175... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Frequency-dependent, bi-directional plasticity in motor cortex of human adults. | OBJECTIVE: To determine whether the plastic changes induced in human motor cortex by afferent stimulation depend on stimulus frequency.METHODS: Transcranial magnetic stimulation was used to examine changes in corticospinal excitability in 20 subjects before and after combined peripheral (motor point) and central stimul... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Differential Threshold', 'Dose-Response Relationship, Radiation', 'Electric Stimulation', 'Electromyography', 'Evoked Potentials, Motor', 'Female', 'Humans', 'Magnetics', 'Male', 'Middle Aged', 'Motor Cortex', 'Neuronal Plasticity', 'Time Factors'] | 12,842,724 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.593.710.370'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500.385', 'G11.561... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile). | Ants are some of the most abundant and familiar animals on Earth, and they play vital roles in most terrestrial ecosystems. Although all ants are eusocial, and display a variety of complex and fascinating behaviors, few genomic resources exist for them. Here, we report the draft genome sequence of a particularly widesp... | ['Animals', 'Ants', 'Base Sequence', 'California', 'DNA Methylation', 'Gene Library', 'Genetics, Population', 'Genome, Insect', 'Genomics', 'Hierarchy, Social', 'Molecular Sequence Data', 'Phylogeny', 'Polymorphism, Single Nucleotide', 'Receptors, Odorant', 'Sequence Analysis, DNA'] | 21,282,631 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.205'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G05.360.325'], ['H01.158.273.343.335'], ['G05.360.340.357'], ['H01.158.273... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 |
Effect of leukotrienes C4 and D4 on prostaglandin I2-liberation from human lymphatics. | Whereas prostaglandin I2 (PGI2), a major metabolite of human lymphatics, does not itself affect lymphatic contractility significantly, it is able to counterbalance the contractile response to thromboxane and leukotrienes. We now demonstrate that leukotrienes C4 and D4 evoke a dose-dependent increased production of PGI2... | ['Adolescent', 'Adult', 'Epoprostenol', 'Female', 'Humans', 'Lymphatic System', 'Male', 'Muscle Contraction', 'SRS-A'] | 3,526,004 | [['M01.060.057'], ['M01.060.116'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A15.382.520'], ['G11.427.494'], ['D10.251.355.255.100.450.855', 'D10.251.355.310.166.887.855', 'D23.469.050.175.450.725']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production. | Complete maturation of hepatitis C virus (HCV) core protein requires coordinate cleavage by signal peptidase and an intramembrane protease, signal peptide peptidase. We show that reducing the intracellular levels of signal peptide peptidase lowers the titer of infectious virus released from cells, indicating that it pl... | ['Amino Acid Sequence', 'Aspartic Acid Endopeptidases', 'Cell Line', 'Electroporation', 'Humans', 'Molecular Sequence Data', 'Mutagenesis', 'Mutation', 'Peptides', 'Plasmids', 'Protein Sorting Signals', 'RNA, Small Interfering', 'RNA, Viral', 'Sequence Homology, Amino Acid', 'Viral Core Proteins'] | 18,424,431 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['A11.251.210'], ['E05.200.500.454', 'E05.242.448', 'E05.301.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.558'], ['G05.365.590'], ['D12.644'], ['G05.360.600'], ['D12.644.770', 'G02.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Obesity paradox in coronary artery bypass grafting: myth or reality? | OBJECTIVE: A high body mass index has been suggested to be protective in patients with coronary artery disease and in those undergoing coronary artery bypass grafting (CABG). However, these conflicting results might be related to the different risk profiles among the various body mass index categories. We sought to cla... | ['Aged', 'Body Mass Index', 'Confounding Factors, Epidemiologic', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Obesity, Morbid', 'Propensity Score', 'Retrospective Studies', 'Risk Factors', 'Time Factors', 'Treatment Outcome'] | 23,870,152 | [['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['N05.715.350.240', 'N06.850.490.718'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sexual dysfunction in HIV-positive men is multi-factorial: a study of prevalence and associated factors. | To establish the prevalence of sexual dysfunction amongst HIV-positive men and to determine the factors associated with dysfunction we conducted a cross-sectional study in seven European HIV treatment centres. Data on medical history, antiretroviral treatment and laboratory results were collected by interview and case ... | ['Adult', 'Antiretroviral Therapy, Highly Active', 'Cross-Sectional Studies', 'Erectile Dysfunction', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Prevalence', 'Sexual Dysfunctions, Psychological', 'Surveys and Questionnaires'] | 17,851,990 | [['M01.060.116'], ['E02.319.310.075'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C12.294.644.486', 'F03.835.400'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endocytosis and exocytosis of protein in capillary endothelium. | The transport of proteins across continuous capillary endothelium is believed to be mediated by micropinocytic vesicles which shuttle molecules between the lumenal and abluminal plasma membrane. We have studied the ability of capillary endothelial cells isolated from rat epididymal fat to endocytose fluorescently label... | ['Animals', 'Biological Transport', 'Capillaries', 'Endocytosis', 'Endothelium', 'Exocytosis', 'Fluorescein-5-isothiocyanate', 'Fluoresceins', 'Fluorescent Dyes', 'Furans', 'Male', 'Ovalbumin', 'Rats', 'Rats, Inbred Strains', 'Rhodamines', 'Spectrometry, Fluorescence', 'Thiocyanates'] | 6,430,919 | [['B01.050'], ['G03.143'], ['A07.015.461.165'], ['G04.417'], ['A10.272.491'], ['G04.468'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275.400', 'D04.711.347.400'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D03... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CAT/CLAMS: its use in detecting early childhood cognitive impairment. | The Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS), a neurodevelopmental tool for the cognitive assessment of infants and toddlers, correlates well with the Bayley Scales of Infant Development. In 1993 the Bayley Scales were revised and the second edition published (BSID-II). This ... | ['Child, Preschool', 'Cognition Disorders', 'Developmental Disabilities', 'Early Intervention, Educational', 'Female', 'Humans', 'Infant', 'Male', 'Neuropsychological Tests', 'Psychometrics', 'Reproducibility of Results'] | 11,033,282 | [['M01.060.406.448'], ['F03.615.250'], ['F03.625.421'], ['N02.421.143.130.320', 'N02.421.726.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F04.711.513'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cell type-specific inhibition of keratinocyte collagenase-1 expression by basic fibroblast growth factor and keratinocyte growth factor. A common receptor pathway. | Collagenase-1 is invariantly expressed by migrating basal keratinocytes in all forms of human skin wounds, and its expression is induced by contact with native type I collagen. However, net differences in enzyme production between acute and chronic wounds may be modulated by soluble factors present within the tissue en... | ['Adult', 'Cells, Cultured', 'Collagenases', 'DNA Primers', 'Exons', 'Female', 'Fibroblast Growth Factor 10', 'Fibroblast Growth Factor 2', 'Fibroblast Growth Factor 7', 'Fibroblast Growth Factors', 'Fibroblasts', 'Gene Expression Regulation, Enzymologic', 'Growth Substances', 'Humans', 'Keratinocytes', 'Kinetics', 'Ma... | 9,218,449 | [['M01.060.116'], ['A11.251'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.024.340.137.232'], ['D12.644.276.624.200', 'D12.776.467.624.200', 'D23.529.624.200'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120']... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later? | OBJECTIVE: Low birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India. Therefore,... | ['Adult', 'Birth Weight', 'Body Weights and Measures', 'Case-Control Studies', 'Cohort Studies', 'Diabetes Mellitus, Type 2', 'Follow-Up Studies', 'Glucose Intolerance', 'Humans', 'India', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Insulin Resistance', 'Male', 'Metabolism', 'Parturition', 'Rural Population', 'Time... | 22,250,073 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E01.370.600.115.100', 'E05.041.124', 'G07.100.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.71... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Calculation of femtosecond pulse laser induced damage threshold for broadband antireflective microstructure arrays. | In order to more exactly predict femtosecond pulse laser induced damage threshold, an accurate theoretical model taking into account photoionization, avalanche ionization and decay of electrons is proposed by comparing respectively several combined ionization models with the published experimental measurements. In addi... | ['Computer Simulation', 'Dose-Response Relationship, Radiation', 'Equipment Design', 'Equipment Failure Analysis', 'Lasers', 'Manufactured Materials', 'Models, Theoretical', 'Radiation Dosage'] | 20,052,125 | [['L01.224.160'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['E05.320'], ['E05.325.192'], ['E07.632.490', 'E07.710.520'], ['J01.637'], ['E05.599'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer. | Regulatory T cells may be crucial in the development of T cell tolerance to malignancies and contribute to immune dysfunctions. We investigated the percentage, activity, and onset of apoptosis of T cell subpopulations by multicolor flow cytometry in metastatic epithelial cancer patients compared to normal controls. Fur... | ['Aged', 'Annexin A5', 'Antigens, CD', 'Apoptosis', 'CD4-Positive T-Lymphocytes', 'CTLA-4 Antigen', 'Carcinoma', 'Female', 'Humans', 'Interleukin-2 Receptor alpha Subunit', 'Lymphocyte Count', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'T-Lymphocyte Subsets', 'T-Lymphocytes, Regulatory', 'fas Receptor'] | 17,939,021 | [['M01.060.116.100'], ['D12.776.157.125.050.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G04.146.954.035'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D12.776.465.782', 'D12.776.543.750.705.222.750', 'D23.050.301.264.894.158', 'D23.101.100.894.158'], ['C... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of rinsing enteral delivery sets on formula contamination. | This study investigated whether rinsing enteral delivery sets before formula addition affects formula contamination. Both a simulated and a clinical phase were conducted. In the simulated phase, Osmolite (Ross Laboratories, Columbus, OH) was infused continuously through 52 delivery sets into a flask via enteral infusio... | ['Adult', 'Enteral Nutrition', 'Equipment Contamination', 'Food Microbiology', 'Humans', 'Therapeutic Irrigation'] | 9,016,145 | [['M01.060.116'], ['E02.421.360', 'E02.642.500.360'], ['N06.850.540'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.779.492.500', 'E02.831.535.492.500', 'E05.927']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
The effects of massive transfusion and haptoglobin therapy on hemolysis in trauma patients. | A retrospective study was conducted on 53 patients who suffered severe trauma to determine the severity of intravascular hemolysis, the variations of renal function after trauma, and the effects of transfusion and haptoglobin therapy on these factors. Serum total haptoglobin, total hemoglobin, and urine free hemoglobin... | ['Acetylglucosaminidase', 'Acute Kidney Injury', 'Adult', 'Blood Transfusion', 'Female', 'Haptoglobins', 'Hemoglobins', 'Hemolysis', 'Humans', 'Injury Severity Score', 'Kidney Function Tests', 'Kidney Tubules, Proximal', 'Male', 'Regression Analysis', 'Retrospective Studies', 'Time Factors', 'Wounds and Injuries'] | 7,865,954 | [['D08.811.277.450.483.180.500'], ['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116'], ['E02.095.135'], ['D12.776.124.050.300', 'D12.776.124.790.106.394', 'D12.776.377.715.085.394', 'D12.776.395.560.373'], ['D12.776.124.400', 'D12.776.422.316.762'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis and anti-virus activity of some nucleosides analogues. | New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3a-g) and 3'-, 5'-thymidine (4a-i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modification on the antiviral activity has been al... | ['Amino Acids', 'Animals', 'Anti-HIV Agents', 'Antiviral Agents', 'Bromodeoxyuridine', 'Cells, Cultured', 'Chick Embryo', 'Chickens', 'Drug Design', 'Fibroblasts', 'HIV', 'Herpesvirus 1, Human', 'Herpesvirus 1, Suid', 'Humans', 'Influenza A virus', 'Microbial Sensitivity Tests', 'Peptides', 'Structure-Activity Relation... | 10,097,408 | [['D12.125'], ['B01.050'], ['D27.505.954.122.388.077.088'], ['D27.505.954.122.388'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.290.500', 'H01.158.703.007.338.500', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracellular reactive oxygen species in monocytes generated by photosensitive chromophores activated with blue light. | OBJECTIVES: Disinfection of the tooth pulp-canal system is imperative to successful endodontic therapy. Yet, studies suggest that 30-50% of current endodontic treatments fail from residual bacterial infection. Photodynamic therapy using red-light chromophores (630 nm) to induce antimicrobial death mediated by generated... | ['Cell Line', 'Chlorophyll', 'Coloring Agents', 'Fluoresceins', 'Fluorescent Dyes', 'Humans', 'Light', 'Mitochondria', 'Monocytes', 'Photosensitizing Agents', 'Polylysine', 'Porphyrins', 'Radiation-Sensitizing Agents', 'Reactive Oxygen Species', 'Riboflavin', 'Succinate Dehydrogenase', 'Tetrazolium Salts', 'Thiazoles'] | 18,243,296 | [['A11.251.210'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D27.720.233'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.65... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Atypical idiopathic scoliosis: MR imaging evaluation. | The authors analyzed the clinical and imaging findings in 30 consecutive pediatric, adolescent, and young adult patients who underwent MR imaging because of atypical features of idiopathic scoliosis. Atypical clinical and plain radiographic features included early onset (n = 4), rapid progression (n = 19), pain (n = 17... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Radiography', 'Retrospective Studies', 'Scoliosis', 'Spine'] | 8,416,573 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.350.825.500'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.5... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Malaria infections are randomly distributed in diverse holoendemic areas of Papua New Guinea. | Malaria is holoendemic in the lowlands of Papua New Guinea (PNG), and interactions among Plasmodium species may influence prevalence of mixed infections. Previously, field samples from a cross-sectional survey in Dreikikir, East Sepik Province, analyzed by blood smear and polymerase chain reaction (PCR), showed that mi... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Animals', 'Blood', 'Blood Specimen Collection', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'DNA, Protozoan', 'Endemic Diseases', 'Humans', 'Infant', 'Infant, Newborn', 'Malaria', 'Middle Aged', 'Papua New Guinea', 'Parasitemia', 'Pla... | 12,518,843 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['A12.207.152', 'A15.145'], ['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.8... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Pharmacological treatment of apathy in Lewy body disorders: A systematic review. | INTRODUCTION: There are no approved treatments for apathy, a frequent and incapacitating symptom in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We reviewed the literature on the pharmacological treatment of apathy in PD and DLB to inform practice and future research.METHOD: We searched PubMed and Psyc... | ['Apathy', 'Cholinesterase Inhibitors', 'Dopamine Agents', 'Humans', 'Lewy Body Disease', 'Parkinson Disease'] | 30,470,658 | [['F01.470.137'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['D27.505.519.625.150', 'D27.505.696.577.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.862.400', 'C10.228.140.380.422', 'C10.228.662.600.200', 'C10.574.928.500', 'F03.615.400.512'], ['C10.228.140... | ['Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Functional imaging of emotional disorders and experiences in schizophrenia patients]. | Functional imaging of normal and dysfunctional emotional processes is an important tool for a better understanding of the pathophysiology of affective symptoms in schizophrenia patients. These symptoms are still poorly characterized with respect to their neural correlates.Comparisons of cerebral activation during emoti... | ['Affective Symptoms', 'Brain', 'Brain Mapping', 'Clinical Trials as Topic', 'Humans', 'Magnetic Resonance Imaging', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Schizophrenia', 'Schizophrenic Psychology'] | 15,696,318 | [['F01.145.126.100'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['N04.761.700.350.650', 'N05.700.350.650'], ['N04.590... | ['Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. | Protein phosphatase 2A is a phosphoserine/threonine phosphatase implicated in many cellular processes. The core enzyme comprises a catalytic and a PR65/A-subunit. The substrate specificity and subcellular localization are determined by a third regulatory B-subunit (PR55/B, PR61/B' and PR72/130/B"). To identify the prot... | ['Alternative Splicing', 'Amino Acid Sequence', 'Animals', 'Gene Library', 'Humans', 'Molecular Sequence Data', 'Oocytes', 'Organ Specificity', 'Phosphoprotein Phosphatases', 'Protein Phosphatase 2', 'Xenopus laevis'] | 12,605,688 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G05.360.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['A05.360.490.690.680', 'A11.497.497.600'], ['G07.650'], ['D08.811.277.352.650.625'], ['D08.811.277.352.650.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. | Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron to neuron. Such a templated seeding process requires that the transferr... | ['Aged', 'Aged, 80 and over', 'Alleles', 'Alzheimer Disease', 'Apolipoproteins E', 'Biomarkers', 'Brain', 'Case-Control Studies', 'Cell Differentiation', 'Cognitive Dysfunction', 'Exosomes', 'Extracellular Vesicles', 'Female', 'Humans', 'Induced Pluripotent Stem Cells', 'Male', 'Neurons', 'Protein Aggregates', 'Protein... | 29,495,441 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['D23.101'], ['A08.186.211'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
DMC is not better than TMZ on intracranial anti-glioma effects. | Previous studies showed Demethoxycurcumin (DMC) has stronger anti-glioma and anti-GSCs effects both in vitro and in vivo. In addition, DMC seems to be lower toxicity than TMZ on nude mice. However, this conclusion was confirmed to be wrong in this study. We have evaluated the antitumor efficacy of DMC or TMZ treatment ... | ['Animals', 'Antineoplastic Agents, Alkylating', 'Apoptosis', 'Brain Neoplasms', 'Cell Proliferation', 'Curcumin', 'Diarylheptanoids', 'Glioma', 'Humans', 'Male', 'Mice', 'Mice, Nude', 'Temozolomide', 'Tumor Cells, Cultured', 'Xenograft Model Antitumor Assays'] | 29,575,236 | [['B01.050'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['G04.146.954.035'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455.426.559.694.222'], ['D02.455.326.14... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transition and transversion rate in the evolution of animal mitochondrial DNA. | We present a further application of the stochastic model previously described (Lanave et al., 1984, 1985) for measuring the nucleotide substitution rate in the mammalian evolution of the mitochondrial DNA (mtDNA). The applicability of this method depends on the validity of "stationarity conditions" (equal nucleotide fr... | ['Animals', 'Base Sequence', 'Biological Evolution', 'DNA, Mitochondrial', 'Gene Frequency', 'Mathematics', 'Models, Genetic', 'Primates'] | 3,801,602 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['D13.444.308.283.225'], ['G05.330'], ['H01.548'], ['E05.599.395.397'], ['B01.050.150.900.649.313.988']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. | Biphenyl dimethyl dicarboxylate (DDB) is a hepatoprotectant, which is used as an adjuvant agent in a treatment for chronic hepatitis. Amantadine is an antiviral agent, which is utilized primarily in the treatment of influenza, but also, occasionally in the treatment of hepatitis C. In a previous study, we reported that... | ['Amantadine', 'Antiviral Agents', 'Cell Line, Tumor', 'Dioxoles', 'Dose-Response Relationship, Drug', 'Drug Combinations', 'Drug Synergism', 'Gene Expression Regulation', 'Hepatitis B virus', 'Hepatocytes', 'Humans', 'Interferon-alpha', 'Membrane Proteins', 'Mitochondrial Proteins', 'RNA, Messenger', 'RNA, Viral', 'Re... | 16,756,086 | [['D02.455.426.100.050.035'], ['D27.505.954.122.388'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.383.246'], ['G07.690.773.875', 'G07.690.936.500'], ['D26.310'], ['G07.690.773.968.477'], ['G05.308'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Species variety of staphylococcal microflora of the skin in athletes engaged in water sports. | Staphylococcal flora of the skin was studied in athletes whose professional activity involved training in water. Inoculations were carried out by impressions in selective agar medium (yolk saline agar; YSA) in bacteriological signets. Drug sensitivity was studied by the disk diffusion method modified by Kerby-Bauer usi... | ['Adolescent', 'Adult', 'Athletes', 'Child', 'Female', 'Humans', 'Male', 'Skin', 'Staphylococcus', 'Swimming', 'Young Adult'] | 22,485,221 | [['M01.060.057'], ['M01.060.116'], ['M01.072'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A17.815'], ['B03.300.390.400.800.750', 'B03.353.500.750.750', 'B03.510.100.750.750', 'B03.510.400.790.750'], ['G11.427.410.568.800', 'G11.427.410.698.277.875', 'I03.350.875', 'I03.450.642.845.945.500'], [... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Muscle wasting in chronic alcoholics: comparative histochemical and biochemical studies. | The comparative electrophysiologic, histochemical, and biochemical investigation of the anterior tibial muscle of 13 alcoholics indicates that neuropathy could be the cause of the chronic muscle weakness and wasting. Myopathic alterations did not predominate in the findings. It was concluded that the proximal muscle at... | ['Adenosine Triphosphatases', 'Adult', 'Alcoholism', 'Axons', 'Dihydrolipoamide Dehydrogenase', 'Electromyography', 'Female', 'Glycogen', 'Glycolysis', 'Humans', 'Male', 'Middle Aged', 'Muscles', 'Muscular Atrophy', 'Neural Conduction', 'Reflex, Stretch', 'Sensation'] | 6,221,080 | [['D08.811.277.040.025'], ['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D05.500.562.452.150', 'D05.500.562.468.500', 'D05.500.562.625.500', 'D08.811.600.391.150', 'D08.811.600.465.500', 'D08.811.600.741.525', 'D08.811.682.657.350.750... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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