Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Treatment options for Dandy-Walker malformation. | OBJECT: The aim of this study was to assess the efficacy of various treatment options available for children with Dandy-Walker malformation (DWM) and to evaluate the role of endoscopic procedures in the treatment of this disorder.METHODS: The authors conducted a retrospective review of 72 children who underwent surgica... | ['Adolescent', 'Brain', 'Cerebral Aqueduct', 'Cerebrospinal Fluid Shunts', 'Child', 'Child, Preschool', 'Dandy-Walker Syndrome', 'Developmental Disabilities', 'Female', 'Follow-Up Studies', 'Humans', 'Hydrocephalus', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Neuroendoscopy', 'Postoperative Complications', 'Reope... | 17,328,256 | [['M01.060.057'], ['A08.186.211'], ['A08.186.211.132.659.413.875.187', 'A08.186.211.140.187'], ['E04.035.188', 'E04.525.170'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.252.300', 'C10.228.140.602.500', 'C10.500.205', 'C16.131.666.205'], ['F03.625.421'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Automatic affective responses to smoking cues. | The authors examined automatic emotional reactions to smoking cues among 35 smokers and 25 nonsmokers (32 women and 28 men), using a novel implicit measure, the Affect Misattribution Procedure. Associative-learning theories of addiction suggest that smokers develop positive responses to cues linked to the rewarding eff... | ['Adolescent', 'Adult', 'Affect', 'Association Learning', 'Cues', 'Female', 'Humans', 'Individuality', 'Male', 'Personality Inventory', 'Photic Stimulation', 'Smoking', 'Smoking Cessation', 'Surveys and Questionnaires', 'Tobacco Use Disorder'] | 17,696,687 | [['M01.060.057'], ['M01.060.116'], ['F01.470.047'], ['F02.463.425.069.296'], ['F02.463.425.234'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['F04.711.647.513'], ['E05.723.729'], ['F01.145.805'], ['F01.145.488.732'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['C25.775.912... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[A multimodal treatment of prostatic carcinoma and the 5-year survival rate]. | One hundred and twenty-nine patients with prostatic carcinoma were treated in our hospital. They were between 49 and 88 (average, 70.3) years old and histological diagnosis was adenocarcinoma in all 129 patients; 42 had well differentiated, 55 moderately differentiated, 31 had poorly differentiated carcinomas, and one ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Combined Modality Therapy', 'Drug Administration Schedule', 'Estrogens', 'Etoposide', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Orchiectomy', 'Prostatic Neoplasms'] | 2,729,020 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['E02.186'], ['E02.319.283'], ['D27.505.696.399.472.277'], ['D02.455.426.559.847.638.960.675.250', 'D04.615.638.960.675.250', 'D09.408.348.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['E04.270.282.679', 'E0... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intracellular signalling systems controlling the 5 alpha-reductase in glial cell cultures. | Glial cells are able to metabolize testosterone into DHT through the action of the enzyme 5 alpha-reductase. DHT may be further processed to 3 alpha-diol by the 3 alpha-hydroxysteroid-dehydrogenase. The aim of this study was to analyze if a modulation of two second messenger systems might be able to modify the 5 alpha-... | ['8-Bromo Cyclic Adenosine Monophosphate', 'Animals', 'Cells, Cultured', 'Cholestenone 5 alpha-Reductase', 'Dihydrotestosterone', 'Enzyme Activation', 'Intracellular Membranes', 'Neuroglia', 'Oxidoreductases', 'Protein Kinases', 'Second Messenger Systems', 'Signal Transduction', 'Testosterone', 'Tetradecanoylphorbol Ac... | 1,511,328 | [['D03.633.100.759.646.138.395.225', 'D13.695.462.200.225', 'D13.695.667.138.395.225', 'D13.695.827.068.395.225'], ['B01.050'], ['A11.251'], ['D08.811.682.660.200'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['G02.111.263', 'G03.328'], ['A11.284.149.450', 'A11.284.835.514'], ['A08.637', 'A11.650'], ['D08.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prepubertal exposure to genistein alleviates di-(2-ethylhexyl) phthalate induced testicular oxidative stress in adult rats. | Di-(2-ethylhexyl) phthalate (DEHP) is the most widely used plastizer in the world and can suppress testosterone production via activation of oxidative stress. Genistein (GEN) is one of the isoflavones ingredients exhibiting weak estrogenic and potentially antioxidative effects. However, study on reproductive effects fo... | ['Animals', 'Diethylhexyl Phthalate', 'Female', 'Genistein', 'Humans', 'Male', 'Organ Size', 'Oxidative Stress', 'Pregnancy', 'Rats', 'Testis', 'Testosterone'] | 25,530,965 | [['B01.050'], ['D02.241.223.805.250'], ['D03.383.663.283.266.450.400.375', 'D03.633.100.150.266.450.400.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['G03.673', 'G07.775.750'], ['G08.686.784.769'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physico-chemical and microstructural changes in collagen fiber bundles following stretch in-vitro. | Simultaneous measurements of load, deformation and diameter were performed on stretched collagen fiber bundle from rat tail tendon using a dynamic, electronically controlled stretch system and a novel computer based electroptical set-up. A parallel analysis of glycosaminoglycan (GAG) concentration in the bathing soluti... | ['Animals', 'Collagen', 'Female', 'Glycosaminoglycans', 'Rats', 'Rats, Inbred Strains', 'Rheology', 'Stress, Mechanical', 'Tendons'] | 3,252,915 | [['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D09.698.373'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['E05.830', 'H01.671.808'], ['G01.374.835'], ['A02.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Thyroid cancer and multiple primary malignancies in Israel. | The exact risk of multiple primary neoplasms in patients with thyroid cancer is difficult to ascertain from the data available in the literature. Three thousand seventy-two patients with thyroid cancer, listed in the Israel Cancer Registry during a 16-year time span, were studied to determine the true incidence of anot... | ['Breast Neoplasms', 'Colorectal Neoplasms', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Incidence', 'Israel', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasms, Multiple Primary', 'Prevalence', 'Registries', 'Risk Factors', 'Survival Rate', 'Thyroid Neoplasms'] | 1,861,493 | [['C04.588.180', 'C17.800.090.500'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.5... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A survey of veterinarian and producer perceptions of herd health services in the Saskatoon milkshed. | A cross-sectional survey was conducted to determine the availability, rates of adoption, and producer perceptions of veterinary services in five areas of dairy production medicine: reproduction, milk quality, nutritional consulting, infectious disease control, and heifer rearing. Questionnaires were completed by all ve... | ['Animals', 'Attitude', 'Cattle', 'Cross-Sectional Studies', 'Dairying', 'Female', 'Saskatchewan', 'Surveys and Questionnaires', 'Veterinary Medicine'] | 8,069,836 | [['B01.050'], ['F01.100'], ['B01.050.150.900.649.313.500.380.271'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['J01.040.246'], ['Z01.107.567.176.858'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['H02.956']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Mutation analysis of the FAS and TNFR apoptotic cascade genes in hematological malignancies. | OBJECTIVE: The existence of properly functioning apoptotic pathways is of utmost importance in the maintenance of a normal cell count. Several groups have searched for mutations in the FAS receptor, a well-characterized apoptotic protein carrying a death domain, and reported the existence of rare mutations in multiple ... | ['Apoptosis', 'Burkitt Lymphoma', 'DNA Mutational Analysis', 'Hematologic Neoplasms', 'Humans', 'Leukemia, Hairy Cell', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Leukemia, Myeloid, Acute', 'Leukemia, Myelomonocytic, Chronic', 'Polycythemia Vera', 'Polymerase Chain Re... | 11,166,462 | [['G04.146.954.035'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.150.165', 'C15.604.515.569.480.150.165', 'C20.683.515.761.480.150.165'], ['E05.393.760.700.300'], ['C04.588.448', 'C15.378.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.415', 'C15.604.515.553', 'C20.683.515... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Single-Center Experience with Intimal Sarcoma, an Ultra-Orphan, Commonly Fatal Mesenchymal Malignancy. | BACKGROUND: Intimal sarcoma is a rare malignancy that, clinically and radiographically, often mimics pulmonary embolism. The intravascular tumor tends to disseminate rapidly and metastases can be present at first diagnosis.METHODS: We reviewed all cases of intimal sarcoma that were diagnosed, treated and followed at th... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Belgium', 'Biomarkers, Tumor', 'Child', 'Child, Preschool', 'Critical Illness', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Rare Diseases', 'Risk Factors', 'Sarcoma', 'Sex Distribution', 'Survival Rate', 'Treatment Outcome', 'Tunica Intima', 'Vascular Ne... | 28,501,860 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['Z01.542.115'], ['D23.101.140'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['C23.550.291.906'], ['E05.318.74... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Prevention of compensatory hyperhidrosis after thoracoscopic sympathectomy for hyperhidrosis. | BACKGROUND: Compensatory hyperhidrosis is a troublesome complication of thoracoscopic sympathectomy for hyperhidrosis. After extensive resection of the second through the fourth ganglion (T2-4), as well as after limited resection of the second ganglion (T2), the reported incidence of compensatory hyperhidrosis ranges a... | ['Adult', 'Female', 'Humans', 'Hyperhidrosis', 'Male', 'Sympathectomy', 'Thoracoscopy'] | 11,727,092 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.946.350'], ['E04.525.210.105.800'], ['E01.370.388.250.840', 'E04.502.250.840', 'E04.928.752']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes. | In catfish (Ictalurus punctatus) hepatocytes angiotensin II induced an immediate increase in cytosolic Ca2+ concentration. Other angiotensin analogues also induced this effect including: human angiotensin II, fish angiotensin II, human angiotensin III, human angiotensin I, fish angiotensin I and saralasin. CGP 42112A i... | ['Angiotensin I', 'Angiotensin II', 'Angiotensin Receptor Antagonists', 'Animals', 'Binding, Competitive', 'Biphenyl Compounds', 'Calcium', 'Cell Membrane', 'Egtazic Acid', 'Humans', 'Ictaluridae', 'Imidazoles', 'Liver', 'Losartan', 'Phosphatidylinositols', 'Pyridines', 'Receptors, Angiotensin', 'Signal Transduction', ... | 9,223,623 | [['D06.472.699.094.075', 'D12.644.400.070.075', 'D12.644.456.073.021', 'D12.644.548.058.075', 'D12.776.631.650.070.075', 'D23.469.050.050.025'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.519.162'], ['B01.050'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. | Osteocalcin (OC), which is a marker of the mature osteoblasts, can also be found in posthypertrophic chondrocytes of the epiphyseal growth plate, but not in chondrocytes of the resting zone or in adult cartilage. In human osteoarthritis (OA), chondrocytes can differentiate to a hypertrophic phenotype characterized by t... | ['Aged', 'Alkaline Phosphatase', 'Arthroplasty, Replacement, Knee', 'Cartilage, Articular', 'Cell Differentiation', 'Chondrocytes', 'Collagen', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization', 'Knee Joint', 'Middle Aged', 'Osteoarthritis', 'Osteocalcin', 'RNA, Messenger'] | 10,954,778 | [['M01.060.116.100'], ['D08.811.277.352.650.035'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['A02.165.407.150', 'A02.835.583.192'], ['G04.152'], ['A11.329.171'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.22... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro polymerization of polyhook protein from Salmonella SJW880. | Polyhooks were isolated from Salmonella SJW880, a non-flagellated mutant, and purified by cesium chloride density gradient centrifugation. The polyhooks were disintegrated into protein subunits (monomer) by heat in the absence of salt. The monomer was repolymerized in the presence of moderately high concentrations of s... | ['Bacterial Proteins', 'Circular Dichroism', 'Citrates', 'Flagella', 'Microscopy, Electron', 'Mutation', 'Polymers', 'Protein Conformation', 'Salmonella'] | 7,437,464 | [['D12.776.097'], ['E05.196.867.151'], ['D02.241.081.901.434'], ['A11.284.180.290'], ['E01.370.350.515.402', 'E05.595.402'], ['G05.365.590'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G02.111.570.820.709'], ['B03.440.450.425.800', 'B03.660.250.150.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Role of brain organization in the pathogenesis of physical disease. | While genetic and environmental factors are known to make substantial contributions to the pathogenesis of physical disease, the role of the brain in these processes is largely unknown. It is hypothesized that the manner in which the brain is functionally organized is an integral factor in physical health outcomes, bot... | ['Animals', 'Brain', 'Death, Sudden, Cardiac', 'Disease', 'Humans', 'Models, Neurological', 'Myocardial Infarction'] | 10,687,894 | [['B01.050'], ['A08.186.211'], ['C14.280.383.220', 'C23.550.260.322.250'], ['C23.550.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.642'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Comparative study of three alternative surgical techniques for hysterectomy]. | In conjunction with the introduction of laparoscopic hysterectomy into wider clinical practice significant changes take place in the evaluation of medical and economic aspects of alternate surgical techniques. In the investigated group the advantages of a minimally invasive and vaginal approach in the evaluation of per... | ['Convalescence', 'Costs and Cost Analysis', 'Female', 'Humans', 'Hysterectomy', 'Hysterectomy, Vaginal', 'Laparoscopy', 'Length of Stay', 'Middle Aged', 'Postoperative Complications'] | 9,600,152 | [['C23.550.291.562'], ['N03.219.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E04.950.300.399.380'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['C23.550.767']] | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Elfn1 regulates target-specific release probability at CA1-interneuron synapses. | Although synaptic transmission may be unidirectional, the establishment of synaptic connections with specific properties can involve bidirectional signaling. Pyramidal neurons in the hippocampus form functionally distinct synapses onto two types of interneurons. Excitatory synapses onto oriens-lacunosum moleculare (O-L... | ['Animals', 'Axons', 'CA1 Region, Hippocampal', 'Cells, Cultured', 'Gene Knockdown Techniques', 'Green Fluorescent Proteins', 'HEK293 Cells', 'Humans', 'Interneurons', 'Mice', 'Nerve Tissue Proteins', 'RNA, Small Interfering', 'Rats', 'Rats, Inbred LEC', 'Synapses', 'Synaptic Transmission'] | 23,042,292 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211.180.405.099', 'A08.186.211.200.885.287.500.345.099'], ['A11.251'], ['E05.393.335.500'], ['D12.776.532.265'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.675.358', 'A11... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus. | We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids are important regulators of vascular tone and may therefore contribute to this hyperaemia... | ['Adult', 'Area Under Curve', 'Aspirin', 'Case-Control Studies', 'Cyclooxygenase Inhibitors', 'Diabetes Mellitus, Type 1', 'Enzyme Inhibitors', 'Exercise', 'Female', 'Humans', 'Hyperemia', 'Male', 'Muscle, Skeletal', 'Plethysmography', 'Regional Blood Flow', 'omega-N-Methylarginine'] | 11,052,918 | [['M01.060.116'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D02.455.426.559.389.657.410.595.176'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.954.158.030.500', 'D27.505.954.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Interactions between dyes and surfactants in inkjet ink used for textiles. | Optimal preparation of inkjet ink should be possible through the elucidation of the relationship between dye/additive interactions and ink performance. In the present study, the interactions between the dyes and surfactant additives were investigated. To investigate the physical properties of the surfactants used, the ... | ['Chemistry, Physical', 'Coloring Agents', 'Drug Interactions', 'Electron Spin Resonance Spectroscopy', 'Ink', 'Micelles', 'Printing', 'Solutions', 'Spectrometry, Fluorescence', 'Surface-Active Agents', 'Textiles', 'Thermodynamics', 'Water'] | 22,123,244 | [['H01.181.529'], ['D27.720.233'], ['G07.690.773.968'], ['E05.196.867.519.274'], ['J01.637.500'], ['D05.374', 'D26.255.560'], ['L01.737.787'], ['D26.776'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['D27.720.877'], ['J01.637.836'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Gastric carcinoma: Evaluation with diffusion-tensor MR imaging and tractography ex vivo. | PURPOSE: To determine the feasibility of diffusion-tensor imaging (DTI) and tractography as means of evaluating the depth of mural invasion by gastric carcinomas.MATERIALS AND METHODS: This study was approved by our institutional review board, and written informed consent was obtained from each patient. Twenty gastric ... | ['Aged', 'Aged, 80 and over', 'Algorithms', 'Diffusion Tensor Imaging', 'Feasibility Studies', 'Female', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'In Vitro Techniques', 'Male', 'Middle Aged', 'Multimodal Imaging', 'Neoplasm Invasiveness', 'Reproducibility of Results', 'Sensitivity and S... | 26,597,835 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.35... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Electrocochleography in experimental animal model with acute hydrolabyrinth]. | A desirable animal model of acute hydrolabyrinth was made by injecting artificial endolymph into the cochlear duct of guinea pigs. In 12 animals with intact Reissner membranes, the endolymphatic potential kept normal after injection of artificial endolymph, but their ECochG showed a rise of SP amplitude, a decrease in ... | ['Animals', 'Audiometry, Evoked Response', 'Edema', 'Guinea Pigs', 'Labyrinth Diseases', 'Reaction Time'] | 2,031,727 | [['B01.050'], ['E01.370.382.375.060.050'], ['C23.888.277'], ['B01.050.150.900.649.313.992.550'], ['C09.218.568'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Comparative study of brain tumors treated at China Medical University, China and Kyushu University, Japan]. | We have re-examined histopathological specimens of brain tumors extirpated at China Medical University from May, 1990 to June, 1992. During the last 2 years, about 400 cases of brain tumors were operated and 349 cases were histopathologically diagnosed and classified by one of the authors (T. I). The most common tumor ... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Brain Neoplasms', 'Child', 'Child, Preschool', 'China', 'Female', 'Glioma', 'Hospitals, University', 'Humans', 'Infant', 'Japan', 'Male', 'Meningioma', 'Middle Aged', 'Neurilemmoma', 'Schools, Medical'] | 1,464,407 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['N02.278.020.300.310',... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome. | AIM: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population.MATERIALS & METHODS: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were... | ['Adult', 'Aged', 'Female', 'Genetic Predisposition to Disease', 'Globulins', 'Humans', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Vitamin D-Binding Protein'] | 29,504,805 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.687.500', 'G05.380.355'], ['D12.776.377'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500.570', 'C18.452.625'], ['M01.060.116.630'], ['G05.365.795.598'], ['D12.776.157.920']] | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Open-label trial of venlafaxine in adults with attention deficit disorder. | Antidepressants or stimulants are commonly used to treat attention deficit disorder (ADD). We report the results of an open-label trial of the recently marketed antidepressant venlafaxine in 16 adult patients with ADD. Patients were treated with venlafaxine (25 to 225 mg/day) for 8 weeks. Four patients discontinued tre... | ['Adult', 'Antidepressive Agents, Second-Generation', 'Attention Deficit Disorder with Hyperactivity', 'Cyclohexanols', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Psychiatric Status Rating Scales', 'Venlafaxine Hydrochloride'] | 8,851,654 | [['M01.060.116'], ['D27.505.954.427.700.122.050'], ['F03.625.094.150'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['F04.711.513.653'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk. | The two related protein-tyrosine kinases Syk and Zap are rapidly phosphorylated on tyrosine residues and enzymatically activated upon crosslinking of the T cell antigen receptor. We have previously reported that the activation of Syk is less dependent on the Src family kinase Lck than the activation of Zap. Here we rep... | ['Animals', 'COS Cells', 'Calcium-Calmodulin-Dependent Protein Kinases', 'DNA-Binding Proteins', 'Enzyme Activation', 'Enzyme Precursors', 'Genes, Reporter', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Jurkat Cells', 'Luciferases', 'Lymphocyte Specific Protein Tyrosine Kinase p56(lck)', 'Lymphocytes', '... | 9,128,727 | [['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['D12.776.260'], ['G02.111.263', 'G03.328'], ['D08.622', 'D12.776.811.243'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nurse-led medicines' monitoring in care homes study protocol: a process evaluation of the impact and sustainability of the adverse drug reaction (ADRe) profile for mental health medicines. | INTRODUCTION: Improved medicines' management could lead to real and sustainable improvements to the care of older adults. The overuse of mental health medicines has featured in many reports, and insufficient patient monitoring has been identified as an important cause of medicine-related harms. Nurse-led monitoring usi... | ['Drug Monitoring', 'Humans', 'Nursing Homes', 'Nursing Staff', 'Observational Studies as Topic', 'Psychotropic Drugs'] | 30,269,073 | [['E01.370.520.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.825.610'], ['M01.526.485.680', 'N02.360.680'], ['E05.318.372.250.500', 'N05.715.360.330.250.500', 'N06.850.520.450.250.500'], ['D27.505.954.427.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells. | Anthracyclines are powerful cytotoxic agents, used as first-line treatment of leukemias and many other tumors, but host-tissue toxicity is their main dose-limiting factor. However, their therapeutic effects depend not only on the toxicity, hence on the dose, but also on drug resistance. Among the mechanisms that can ac... | ['Amifostine', 'Antibiotics, Antineoplastic', 'Apoptosis', 'Cell Survival', 'Cells, Cultured', 'Chemistry, Pharmaceutical', 'Daunorubicin', 'Drug Carriers', 'Hematopoietic Stem Cells', 'Humans', 'Liposomes', 'Lymphocytes', 'Mercaptoethylamines', 'Radiation-Protective Agents', 'Tumor Cells, Cultured', 'Tumor Stem Cell A... | 16,001,170 | [['D02.705.400.625.050', 'D02.705.539.345.050', 'D02.886.300.692.050'], ['D27.505.954.248.106'], ['G04.146.954.035'], ['G04.346'], ['A11.251'], ['H01.158.703.007', 'H01.181.466'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.059.200'], ['D26.255.260', 'E02.319.300.380'], ['A11.148.378', 'A11.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Clinicopathological and immunohistochemical study of 30 cases of post-radiation atypical vascular lesion of the breast. | Atypical vascular lesions (AVL) that occur in the field of prior radiation therapy for breast carcinoma are placed within the differential diagnosis with low grade angiosarcoma and other benign vascular lesions. Although considered a benign entity, the exact biological behavior of AVLs is not fully established because ... | ['Adult', 'Aged', 'Breast', 'Breast Neoplasms', 'Female', 'Follow-Up Studies', 'Hemangiosarcoma', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'Neoplasms, Radiation-Induced', 'Radiotherapy', 'Treatment Outcome'] | 24,943,869 | [['M01.060.116'], ['M01.060.116.100'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.557.450.795.390', 'C04.557.645.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in monkeys. | Subcutaneous injections of a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in monkeys induced distinct behavioural changes characterized by head weaving, hindlimb extension and upper limb fluttering. The effects were dose-dependent and were similar to the 5-HT syndrome induced in rats by ... | ['8-Hydroxy-2-(di-n-propylamino)tetralin', 'Animals', 'Behavior, Animal', 'Macaca fascicularis', 'Male', 'Metergoline', 'Naphthalenes', 'Tetrahydronaphthalenes'] | 2,139,614 | [['D02.455.426.559.847.638.960.400', 'D04.615.638.960.400'], ['B01.050'], ['F01.145.113'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['D03.132.327.287.630', 'D03.633.400.439.630'], ['D02.455.426.559.847.638', 'D04.615.638'], ['D02.455.426.559.847.638.960', 'D04.615.638.960']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Liposome-mediated transfer of vascular endothelial growth factor cDNA augments survival of random-pattern skin flaps in the rat. | Tissue engineering is an application for gene therapy that is in its infancy. We show that simple liposomal-mediated gene transfer could result in a potentially useful biological effect in the field of wound healing. cDNA encoding the 165 amino acid form of vascular endothelial growth factor complexed to commercially a... | ['Animals', 'DNA, Complementary', 'Dermatologic Surgical Procedures', 'Female', 'Gene Transfer Techniques', 'Growth Substances', 'Injections, Intradermal', 'Liposomes', 'Models, Animal', 'Rats', 'Rats, Sprague-Dawley', 'Skin', 'Surgical Flaps', 'Tissue Survival', 'Vascular Endothelial Growth Factor A', 'Wound Healing'] | 14,974,968 | [['B01.050'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['E04.680.275'], ['E05.393.350'], ['D27.505.696.377'], ['E02.319.267.530.620.410'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['E05.598'], ['B01.050.150.900.649.313.992.635.505.700'], ['B... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Localization and quaternary structure of the PKA RIâ holoenzyme. | Specificity for signaling by cAMP-dependent protein kinase (PKA) is achieved by both targeting and isoform diversity. The inactive PKA holoenzyme has two catalytic (C) subunits and a regulatory (R) subunit dimer (R(2):C(2)). Although the RIá, RIIá, and RIIâ isoforms are well studied, little is known about RIâ. We show ... | ['Animals', 'Crystallography, X-Ray', 'Cyclic AMP-Dependent Protein Kinase RIbeta Subunit', 'Holoenzymes', 'Mice', 'Protein Structure, Quaternary', 'Second Messenger Systems', 'Structure-Activity Relationship'] | 22,797,896 | [['B01.050'], ['E05.196.309.742.225'], ['D08.811.913.696.620.682.700.150.125.750.750', 'D12.644.360.200.125.750.750', 'D12.776.476.200.125.750.249'], ['D08.811.255'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.570.820.709.550'], ['G02.111.820.800', 'G04.835.800'], ['G02.111.830', 'G07.690.773.997']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interspecific, intraspecific and interoperonic variability in the 16S rRNA gene of methanogens revealed by length and single-strand conformation polymorphism analysis. | Thirty-seven strains of mesophilic and thermophilic methanogenic Archaea, belonging to 30 species, were analyzed by length polymorphism (LP) and single-strand conformation polymorphism (SSCP) of an amplified 300-bp fragment of the 16S rRNA gene (Escherichia coli positions 9-331) including the variable regions V1 and V2... | ['DNA, Archaeal', 'DNA, Ribosomal', 'Euryarchaeota', 'Polymerase Chain Reaction', 'Polymorphism, Single-Stranded Conformational', 'RNA, Archaeal', 'RNA, Ribosomal, 16S', 'rRNA Operon'] | 9,682,489 | [['D13.444.308.180'], ['D13.444.308.475'], ['B02.200'], ['E05.393.620.500'], ['G05.365.795.600'], ['D13.444.735.300'], ['D13.444.735.686.670'], ['G05.360.340.024.686.817', 'G05.360.340.358.207.500.817']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exacerbation of experimental murine cutaneous leishmaniasis with CD4+ Leishmania major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type hypersensitivity. | Leishmania major-specific T cell lines were derived from mice sensitized to the parasite. The cells were of the CD4+ T cell lineage and, upon adoptive transfer, were found to be capable of inducing parasite-specific delayed-type hypersensitivity. Adoptive transfer of these L. major-specific T cells to syngeneic recipie... | ['Animals', 'CD4-Positive T-Lymphocytes', 'Clone Cells', 'Hypersensitivity, Delayed', 'Immunization, Passive', 'In Vitro Techniques', 'Interferon-gamma', 'Interleukin-2', 'Interleukin-4', 'Leishmania tropica', 'Leishmaniasis', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred Strains'] | 1,672,641 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.251.353'], ['C20.543.418'], ['E02.095.465.425.400.330', 'E05.478.550.520'], ['E05.481'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.3... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Portuguese version of Rhinitis and Asthma Patient's Perspective (RAPP): Validation and assessment. | BACKGROUND: Allergic rhinitis (AR) and asthma are two common chronic diseases that often coexist. There is a need for a validated tool to evaluate HRQoL of Portuguese speakers with asthma and/or rhinitis patients in clinical practice.OBJECTIVES: To adapt and validate RhinAsthma Patient Perspective (RAPP) in Portuguese.... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Asthma', 'Chronic Disease', 'Comorbidity', 'Ethnic Groups', 'Female', 'Health Status', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Rhinitis', 'Rhinitis, Allergic', 'Surveys and Questionnaires', 'Translations', 'Young Adult'] | 30,737,172 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C23.550.291.500'], ['N05.715.350.225', 'N06.850.490.687'], ['M01.686.754', 'N01.224.317'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Expression of bacterial superantigen genes in mice induces localized mononuclear cell inflammatory responses. | Bacterial superantigens are potent T cell activators, and superantigen proteins have been injected into mice and other animals to study T cell responses in vivo. When superantigen proteins are injected, however, the T cell stimulatory effects cannot be confined to specific tissues. Therefore, to target superantigen exp... | ['Animals', 'Cell Line', 'Dogs', 'Enzyme-Linked Immunosorbent Assay', 'Gene Transfer Techniques', 'Genetic Therapy', 'Humans', 'Inflammation', 'Leukocytes, Mononuclear', 'Mice', 'Superantigens', 'T-Lymphocytes'] | 9,169,491 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E05.393.350'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['A11.11... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Periodicity of arrhythmias in healthy elderly men at the moderate altitude. | The 24-hour periodicity of supraventricular (SVPB) and ventricular (VEB) extrasystoles in healthy elderly men (age 49-69 years) was studied at two altitudes during 24 h Holter ECG monitoring. At the low altitude (200 m, n = 26), SVPB were more frequent than VEB. The highest occurrence of SVPB was at 17:00 h, the lowest... | ['Aged', 'Altitude', 'Cardiac Complexes, Premature', 'Czech Republic', 'Electrocardiography, Ambulatory', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Periodicity'] | 10,984,096 | [['M01.060.116.100'], ['G16.500.275.058', 'N06.230.058'], ['C14.280.067.325', 'C14.280.123.375', 'C23.550.073.325'], ['Z01.542.248.395'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.85... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Extracorporeal membrane oxygenation as a bridge to lung transplantation]. | OBJECTIVE: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (LTx).METHODS: The clinical data of 18 patients with end-stage lung diseases was retrospectively reviewed, using ECMO as a bridge to LTx in intensive care unit of Affiliated Wuxi People's Hospital from Ja... | ['Adult', 'Aged', 'Extracorporeal Membrane Oxygenation', 'Female', 'Humans', 'Lung Diseases', 'Lung Transplantation', 'Male', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome', 'Young Adult'] | 30,592,952 | [['M01.060.116'], ['M01.060.116.100'], ['E02.880.301', 'E04.292.451'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
CT and CT-perfusion findings of reversible leukoencephalopathy during triple-H therapy for symptomatic subarachnoid hemorrhage-related vasospasm. | BACKGROUND: Reversible leukoencephalopathy syndrome (RLS) is an acute neurological syndrome associated with altered mental status and visual disturbances described in patients with sudden elevations in systemic blood pressure and other medical conditions. In this process, neuroimaging studies usually demonstrate diffus... | ['Aged', 'Albumins', 'Brain Edema', 'Cerebral Angiography', 'Diagnosis, Differential', 'Female', 'Humans', 'Hypertensive Encephalopathy', 'Phenylephrine', 'Sodium Chloride', 'Subarachnoid Hemorrhage', 'Syndrome', 'Tomography, X-Ray Computed', 'Vasospasm, Intracranial'] | 16,629,742 | [['M01.060.116.100'], ['D12.776.034'], ['C10.228.140.187'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.631.500'], ['D02.033.100.291.617... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[ERRORS IN DIAGNOSIS AND TREATMENT OF IMMUNODEPENDENT PATHOLOGY (ORIGINAL CONCEPT)]. | Based on many years of experience in 2009, we developed the original concept of a mixed approach to the treatment of infectious diseases in patients. During 2.5 years(from 2013 to June 2015) to have applied for consultative-diagnostic help of 3965 patients who had not verified the primary diagnosis. The basic principle... | ['Animals', 'Antifungal Agents', 'Antiparasitic Agents', 'Antiviral Agents', 'Ascariasis', 'Ascaris', 'Candida albicans', 'Candidiasis', 'Diagnostic Errors', 'Epstein-Barr Virus Infections', 'Female', 'Giardia lamblia', 'Giardiasis', 'Herpesvirus 4, Human', 'Humans', 'Immunocompromised Host', 'Immunoglobulin G', 'Immun... | 27,491,144 | [['B01.050'], ['D27.505.954.122.136'], ['D27.505.954.122.250'], ['D27.505.954.122.388'], ['C01.610.335.508.700.100.070'], ['B01.050.500.500.294.400.500.100.108'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C01.150.703.160'], ['E01.354', 'N02.421.450.280'], ['C01.925.256.466.313', 'C01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
New Crosslinked Hyaluronan Gel for the Prevention of Intrauterine Adhesions after Dilation and Curettage in Patients with Delayed Miscarriage: A Prospective, Multicenter, Randomized, Controlled Trial. | STUDY OBJECTIVES: To evaluate the efficacy of a new crosslinked hyaluronan (NCH) gel in reducing the formation of intrauterine adhesions (IUAs) after dilation and curettage (D&C).DESIGN: Randomized controlled trial (Canadian Task Force classification I).SETTINGS: Six hospitals for maternal and child healthcare in China... | ['Abortion, Spontaneous', 'Adolescent', 'Adult', 'China', 'Cross-Linking Reagents', 'Dilatation', 'Dilatation and Curettage', 'Double-Blind Method', 'Female', 'Gels', 'Humans', 'Hyaluronic Acid', 'Hysteroscopy', 'Middle Aged', 'Pregnancy', 'Prospective Studies', 'Tissue Adhesions', 'Uterine Diseases', 'Young Adult'] | 29,678,756 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.057'], ['M01.060.116'], ['Z01.252.474.164'], ['D27.720.470.410.210'], ['E05.284'], ['E04.157.310', 'E04.950.300.299'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.649.31... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ovarian small cell carcinoma: A case report with histologic, immunohistochemical and ultrastructural findings. | A rare case of ovarian small cell carcinoma occurring in a 22-year-old pregnant woman is presented. Despite extensive therapy including surgery, combination chemotherapy and irradiation, the patient died after 23 months. The histologic, immunohistochemical and ultrastructural features are described. The literature is r... | ['Adult', 'Carcinoma, Small Cell', 'Female', 'Humans', 'Intermediate Filament Proteins', 'Necrosis', 'Ovarian Neoplasms'] | 1,652,993 | [['M01.060.116'], ['C04.557.470.200.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593', 'D12.776.220.475'], ['C23.550.717'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Value of coral implant in the treatment of functional failure after subtotal laryngectomy with crico-hyoid fixation]. | Subtotal laryngectomy with CHP have prolongated post operative care because aspiration. In 16% of cases a new surgical procedure is necessary. The authors have used a implant of madreporic coral placed in the base of the tongue just behind the hyoid bone to achieve a total closure of the larynx during swallowing. This ... | ['Bone Substitutes', 'Deglutition Disorders', 'Humans', 'Hyoid Bone', 'Laryngectomy', 'Prostheses and Implants', 'Retrospective Studies'] | 7,726,477 | [['D25.130.325', 'J01.637.051.130.325'], ['C06.405.117.119', 'C09.775.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.409'], ['E04.580.369'], ['E07.695'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.5... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. | Prepulse inhibition (PPI) of the acoustic startle reflex is a sensorimotor gating process known to be deficient in a number of neurologic and psychiatric conditions, including schizophrenia. Multiple lines of evidence have indicated that the dopaminergic and muscarinic cholinergic systems play an important role in modu... | ['Acoustic Stimulation', 'Animals', 'Apomorphine', 'Benzazepines', 'Cognition Disorders', 'Dose-Response Relationship, Drug', 'Haloperidol', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Dopamine', 'Receptors, Muscarinic', 'Reflex', 'Reflex, Startle'] | 15,574,685 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['D03.633.100.079'], ['F03.615.250'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.522.352.506'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions. | Gap junctions (GJs) are dynamic structures composed of hexamers of connexins (Cxs), a class of transmembrane proteins enabling channel-mediated direct intercellular communication through cell-cell diffusion of ions and small metabolites. In defined conditions, Cxs also work as hemichannels allowing exchanges between th... | ['Cell Line, Tumor', 'Connexin 43', 'Dose-Response Relationship, Drug', 'Gap Junctions', 'High-Throughput Screening Assays', 'Humans', 'Mefloquine'] | 31,314,551 | [['A11.251.210.190', 'A11.251.860.180'], ['D12.776.543.585.250.200'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.284.149.165.420.471'], ['E05.916.680'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.810.410']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro time-dependent vancomycin-resistant Staphylococcus aureus-induced free radical generation and status of antioxidant enzymes in murine peritoneal macrophage. | Staphylococcus aureus is most frequently isolated pathogen causing bloodstream infections, skin and soft tissue infections, and pneumonia. The immune cells use reactive oxygen species (ROS) for carrying out their normal functions, while an excess amount of ROS can attack cellular components that lead to cell damage. Th... | ['Animals', 'Antioxidants', 'Catalase', 'Cells, Cultured', 'Free Radicals', 'Glutathione', 'Glutathione Peroxidase', 'Lipid Peroxidation', 'Macrophages, Peritoneal', 'Male', 'Mice', 'NADPH Oxidases', 'Nitric Oxide', 'Peroxidase', 'Protein Carbonylation', 'Staphylococcus aureus', 'Superoxide Dismutase', 'Superoxides', '... | 21,958,328 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D08.811.682.732.332'], ['A11.251'], ['D01.339', 'D02.389'], ['D12.644.456.448'], ['D08.811.682.732.500'], ['G02.111.515', 'G03.295.531.587'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630', 'A15.382.680.397.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3H-Haloperidol binding to dopamine receptors in rat corpus striatum: influence of chlorpromazine metabolites and derivatives. | A series of chlorpromazine metabolites and derivatives have been assayed for their ability to compete with 3H-haloperidol binding to dopamine receptors in membranes of rat corpus striatum. 3-Hydroxylation of chlorpromazine doubles affinity for receptor sites, while 7-hydroxychlorpromazine has a potency similar to that ... | ['Animals', 'Chlorpromazine', 'Corpus Striatum', 'Haloperidol', 'Hydroxylation', 'In Vitro Techniques', 'Rats', 'Receptors, Dopamine'] | 631,182 | [['B01.050'], ['D02.886.369.198', 'D03.633.300.783.198'], ['A08.186.211.200.885.287.249.487'], ['D02.522.352.506'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['E05.481'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750.670.300.400', 'D12.776.543.750.695.150.400', 'D12.776.543.750.720.330.400']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Attribution, cognition and psychopathology in persistent insomnia disorder: outcome and mediation analysis from a randomized placebo-controlled trial of online cognitive behavioural therapy. | OBJECTIVES: Insomnia patients complain that mental events keep them awake. This study investigates how cognitive behavioural therapy (CBT) affects such events and considers how attributional, cognitive and psychopathological symptoms may mediate sleep improvement.METHOD: A pragmatic, parallel-group randomized controlle... | ['Adolescent', 'Adult', 'Aged', 'Cognition', 'Cognitive Behavioral Therapy', 'Humans', 'Middle Aged', 'Online Systems', 'Psychiatric Status Rating Scales', 'Psychological Tests', 'Psychopathology', 'Sleep Initiation and Maintenance Disorders', 'Surveys and Questionnaires', 'Treatment Outcome', 'Young Adult'] | 24,791,643 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.188'], ['F04.754.137.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['L01.313.500.750.300.742'], ['F04.711.513.653'], ['F04.711'], ['F04.096.670'], ['C10.886.425.800.800', 'F03.870.400.800.800'], ['E05.318.308.980', 'N05.715... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Synthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs). | Dendrimers are efficient drug delivery systems particularly useful in ocular diseases. In particular, low generation PAMAM dendrimers are non-toxic and non-immunogenic and they provide an enhancement of the residence time of drugs in the eyes. In this context, the synthesis of the PAMAM-based matrix metalloproteinases ... | ['Binding Sites', 'Dendrimers', 'Dose-Response Relationship, Drug', 'Fluorometry', 'Humans', 'Matrix Metalloproteinase 9', 'Matrix Metalloproteinase Inhibitors', 'Molecular Structure', 'Structure-Activity Relationship'] | 27,914,947 | [['G02.111.570.120'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.712.516.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.480.205.360', 'D08.811.277.656.300.480.252.445', 'D08.811.277.656.300.480.525.700.350', 'D08.811.27... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Platelet release reaction and plasma catecholamines during total hip replacement. No effects of high doses of corticosteroids. | Platelet activation and catecholamine levels during surgery and the effects of corticosteroids on these reactions were examined in fourteen patients operated by uncemented total hip replacement (THR). Beta-thromboglobulin (BTG), released from alpha granules during platelet activation, catecholamines and cortisol were e... | ['Adrenal Cortex Hormones', 'Aged', 'Blood Platelets', 'Catecholamines', 'Dose-Response Relationship, Drug', 'Female', 'Hip', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Platelet Activation'] | 2,300,922 | [['D06.472.040'], ['M01.060.116.100'], ['A11.118.188', 'A15.145.229.188'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['G07.690.773.875', 'G07.690.936.500'], ['A01.378.610.400'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G09.188.390.600']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nonlinear progressive wave equation for stratified atmospheres. | The nonlinear progressive wave equation (NPE) [McDonald and Kuperman, J. Acoust. Soc. Am. 81, 1406-1417 (1987)] is expressed in a form to accommodate changes in the ambient atmospheric density, pressure, and sound speed as the time-stepping computational window moves along a path possibly traversing significant altitud... | ['Acoustics', 'Atmosphere', 'Atmospheric Pressure', 'Computer Simulation', 'Mathematical Computing', 'Nonlinear Dynamics', 'Sound', 'Temperature', 'Time Factors'] | 22,087,891 | [['H01.671.031'], ['G16.500.275.063', 'N06.230.300.100'], ['G16.500.750.274', 'N06.230.300.100.185'], ['L01.224.160'], ['L01.224.680'], ['E05.599.850', 'H01.548.675'], ['G01.750.770.776'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.910.857']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Down syndrome serum marker screening: decision criteria and implicit values. | Maternal serum markers assess the individual risk of giving birth to a fetus with Down syndrome. Because this information is a probability, and because of the infinite number of cut-off risks that can be adopted, a decision criterion is needed to define a population screening program. While a decision criterion for cut... | ['Adult', 'Amniocentesis', 'Biomarkers', 'Cost-Benefit Analysis', 'Decision Making', 'Diagnostic Tests, Routine', 'Down Syndrome', 'Female', 'France', 'Health Care Rationing', 'Health Policy', 'Humans', 'Maternal-Fetal Exchange', 'Outcome Assessment, Health Care', 'Pregnancy', 'Prenatal Diagnosis', 'Risk Assessment', '... | 10,178,803 | [['M01.060.116'], ['E01.370.225.500.384.050', 'E01.370.225.998.329.309', 'E01.370.378.630.050', 'E04.665.600.309', 'E05.200.500.384.050', 'E05.200.998.329.309', 'E05.242.384.050'], ['D23.101'], ['N03.219.151.125'], ['F02.463.785.373'], ['E01.370.395'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]',... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Ischemic stroke in patients with intermittent claudication: a clinical study of 142 cases. | The clinical features, risk factors, neuroimaging findings, and outcome of acute ischemic stroke were assessed in patients with intermittent claudication. Data from 142 patients with ischemic stroke and intermittent claudication were collected from a prospective hospital-based stroke registry in which 2500 consecutive ... | ['Aged', 'Aged, 80 and over', 'Brain Ischemia', 'Female', 'Humans', 'Intermittent Claudication', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Prognosis', 'Prospective Studies', 'Registries', 'Risk Factors', 'Stroke'] | 15,230,483 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E01.789'], ['E05.318.372.500.750.625',... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mistreatment and the Learning Environment: A Mixed Methods Approach to Assess Knowledge and Raise Awareness Amongst Residents. | OBJECTIVE: Trainee mistreatment, either intentional or unintentional, negatively affects the learning environment. This study was undertaken to evaluate the impact of an educational intervention about mistreatment and the learning environment on general surgery residents.DESIGN: Video-based modules were developed and a... | ['Adult', 'Bullying', 'Curriculum', 'Female', 'General Surgery', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Internship and Residency', 'Learning', 'Male', 'Self Report'] | 30,318,301 | [['M01.060.116'], ['F01.145.126.125.550', 'F01.145.813.213.500', 'I01.880.735.070'], ['I02.158'], ['H02.403.810.300'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['F02.463.425', 'F02.784.629.529'], ['E05.318.308.980.500', 'N05... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats. | BACKGROUND: Cardamom is a well-known spice in Indian subcontinent, used in culinary and traditional medicine practices since ancient times. The current investigation was untaken to evaluate the potential benefit of cardamom powder supplementation in high carbohydrate high fat (HCHF) diet induced obese rats.METHOD: Male... | ['Abdominal Fat', 'Alanine Transaminase', 'Alkaline Phosphatase', 'Animals', 'Antioxidants', 'Aspartate Aminotransferases', 'Diet, High-Fat', 'Dietary Carbohydrates', 'Disease Models, Animal', 'Dyslipidemias', 'Elettaria', 'Glucose', 'Glucose Intolerance', 'Glucose Tolerance Test', 'Glycation End Products, Advanced', '... | 28,806,968 | [['A10.165.114.830.500'], ['D08.811.913.477.700.100'], ['D08.811.277.352.650.035'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D08.811.913.477.700.225'], ['G07.203.650.240.267'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C18.452.58... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Rapid method for isolating polychlorinated diphenyls from fat]. | Clophen A-60 was isolated from trioleate by a modification of the method of Veierov and Aharonson. In comparison with the original method the change included the replacement of the glass set for separation of the organic phase with Hehner's cylinder, and in place of petrol ether n-hexane was used. The reproducibility o... | ['Fats', 'Methods', 'Polychlorinated Biphenyls'] | 2,513,639 | [['D10.212'], ['E05.581'], ['D02.309.750', 'D02.455.426.559.389.185.698', 'D02.455.526.439.773']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of influenza immunization on CYP3A4 activity. | A number of clinical reports of drug interactions with influenza vaccine have been made. We hypothesized that CYP3A4 activity would decrease following influenza immunization. Fifteen healthy subjects had erythromycin breath tests (ERMBT) and influenza antibody titer hemagglutinin inhibition assay (HIA) before and after... | ['Adult', 'Breath Tests', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 Enzyme System', 'Erythromycin', 'Female', 'Humans', 'Influenza Vaccines', 'Liver', 'Male', 'Mixed Function Oxygenases'] | 11,738,750 | [['M01.060.116'], ['E01.370.100'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.682.690.708.170.495.500', 'D12.776.422.220.453.860.500'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D02.540.576.500.992'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.215.894.899.302'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dual regulation of energy metabolism by p53 in human cervix and breast cancer cells. | The role of p53 as modulator of OxPhos and glycolysis was analyzed in HeLa-L (cells containing negligible p53 protein levels) and HeLa-H (p53-overexpressing) human cervix cancer cells under normoxia and hypoxia. In normoxia, functional p53, mitochondrial enzyme contents, mitochondrial electrical potential (ÄØm) and OxP... | ['Breast Neoplasms', 'Cell Division', 'Cell Hypoxia', 'Energy Metabolism', 'Female', 'HeLa Cells', 'Humans', 'MCF-7 Cells', 'Tumor Suppressor Protein p53', 'Uterine Cervical Neoplasms'] | 26,434,996 | [['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G03.197.300', 'G04.270.300'], ['G03.295'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.630'], ['D12.776.157.687.650', 'D1... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Acute disorder of ventilation-perfusion of the lung caused by inhalative smoking of 20 cigarettes]. | What are the acute bronchopulmonary reactions which occur in smokers when 20 cigarettes are smoked over 10 hours during the day after a 12-hour interruption of smoking at night? Nineteen healthy chronic smokers with normal lung function aged from 22 to 39 years were investigated. The inhalative smoking characteristics ... | ['Adult', 'Airway Resistance', 'Carbon Dioxide', 'Female', 'Humans', 'Male', 'Smoking', 'Ventilation-Perfusion Ratio'] | 8,584,532 | [['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.805'], ['E01.370.386.700.650.900', 'G09.772.920']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells. | Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-1... | ['Animals', 'Antigen-Presenting Cells', 'Base Sequence', 'Cell Communication', 'Clone Cells', 'Down-Regulation', 'Feedback', 'Immune Tolerance', 'Interleukin-10', 'Interleukin-12', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Spleen', 'Th2 Cells'] | 8,605,930 | [['B01.050'], ['A11.066', 'A15.382.066'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.085'], ['A11.251.353'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['L01.906.394.211'], ['G12.535.425'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.276.374.465... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia. | BACKGROUND: Frankia are actinobacteria that form a symbiotic nitrogen-fixing association with actinorhizal plants, and play a significant role in actinorhizal plant colonization of metal contaminated areas. Many Frankia strains are known to be resistant to several toxic metals and metalloids including Pb(2+), Al(+3), S... | ['Adenosine Triphosphatases', 'Amino Acid Sequence', 'Bacterial Proteins', 'Frankia', 'Homeostasis', 'Metals', 'Molecular Sequence Data', 'Plant Roots', 'Sequence Homology, Amino Acid'] | 25,495,525 | [['D08.811.277.040.025'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['B03.510.024.325', 'B03.585.420'], ['G07.410'], ['D01.552'], ['L01.453.245.667'], ['A18.400'], ['G02.111.810.200', 'G05.810.200']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. | Nuclear factor-kappaB (NF-kappaB) is tightly modulated by IkappaB kinases and IkappaBalpha in the cytoplasm. On stimulation, NF-kappaB translocates into the nucleus to initiate transcription; however, regulation of its transcriptional activity remains obscure. Here, we show that protein kinase C (PKC) delta controls th... | ['Active Transport, Cell Nucleus', 'Apoptosis', 'Cell Line', 'Cell Line, Tumor', 'Cell Nucleus', 'Chromatin Immunoprecipitation', 'Electrophoretic Mobility Shift Assay', 'Humans', 'Immunoblotting', 'In Situ Nick-End Labeling', 'Interleukin-6', 'NF-kappa B', 'Protein Binding', 'Protein Kinase C-delta', 'Protein Transpor... | 19,549,902 | [['G03.143.310.100', 'G03.143.700.100'], ['G04.146.954.035'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.393.170', 'E05.478.605.160'], ['E05.196.401.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['E... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour. | Lactic acid bacteria can affect the maturation of immune cells and their products not only in the gut but also on the systemic immune organs such as lymph nodes and spleen. In the present work, we studied the effects of oral administration of Lactobacillus acidophilus on the immune responses of BALB/c mice bearing tran... | ['Adenocarcinoma', 'Administration, Oral', 'Animals', 'Female', 'Gene Expression Regulation', 'Interleukin-12', 'Lactobacillus acidophilus', 'Mammary Neoplasms, Animal', 'Mice', 'Mice, Inbred BALB C', 'Neoplasm Transplantation', 'Probiotics', 'Spleen'] | 20,193,099 | [['C04.557.470.200.025'], ['E02.319.267.100'], ['B01.050'], ['G05.308'], ['D12.644.276.374.465.512', 'D12.776.467.374.465.512', 'D23.529.374.465.512'], ['B03.353.750.450.475.100', 'B03.510.460.400.410.475.475.100', 'B03.510.550.450.475.100'], ['C04.588.531', 'C22.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
H2S protects against methionine-induced oxidative stress in brain endothelial cells. | Homocysteine (Hcy) causes cerebrovascular dysfunction by inducing oxidative stress. However, to date, there are no strategies to prevent Hcy-induced oxidative damage. Hcy is an H2S precursor formed from methionine (Met) metabolism. We aimed to investigate whether H2S ameliorated Met-induced oxidative stress in mouse br... | ['Acetophenones', 'Acetylcysteine', 'Animals', 'Brain', 'Catalase', 'Cell Line, Transformed', 'Cell Survival', 'Dose-Response Relationship, Drug', 'Endothelial Cells', 'Formazans', 'Glutathione', 'Homocysteine', 'Hydrogen Sulfide', 'Methionine', 'Mice', 'Models, Biological', 'NG-Nitroarginine Methyl Ester', 'Oxidative ... | 18,837,652 | [['D02.522.120'], ['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['A08.186.211'], ['D08.811.682.732.332'], ['A11.251.210.172'], ['G04.346'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.436.275'], ['D02.172.600'], ['D12.644.456.448'], ['D02.886.030.498', 'D12.125.166.498'], ['D01.029.260.340', 'D01.362.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduced accuracy and sensitivity in the perception of emotional facial expressions in individuals with high autism spectrum traits. | Autism spectrum disorder (ASD) is among other things characterized by specific impairments in emotion processing. It is not clear, however, to what extent the typical decline in affective functioning is related to the specific autistic traits. We employed The Autism Spectrum-Quotient (AQ) to quantify autistic traits in... | ['Adolescent', 'Child Development Disorders, Pervasive', 'Emotions', 'Facial Expression', 'Female', 'Humans', 'Male', 'Pattern Recognition, Visual', 'Phenotype', 'Social Perception', 'Young Adult'] | 22,987,888 | [['M01.060.057'], ['F03.625.164'], ['F01.470'], ['E01.370.600.225', 'F01.145.209.530.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['G05.695'], ['F02.463.593.752'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Management and classification of first branchial cleft anomalies]. | OBJECTIVE: We aimed to identify the different courses of first branchial cleft anomalies and to discuss the management and classification of these anomalies.METHOD: Twenty-four patients with first branchial cleft anomalies were reviewed. The courses of first branchial cleft anomalies and their corresponding managements... | ['Adolescent', 'Adult', 'Branchial Region', 'Child', 'Child, Preschool', 'Craniofacial Abnormalities', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Pharyngeal Diseases', 'Retrospective Studies', 'Young Adult'] | 24,073,574 | [['M01.060.057'], ['M01.060.116'], ['A16.142'], ['M01.060.406'], ['M01.060.406.448'], ['C05.660.207', 'C16.131.621.207'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['C07.550', 'C09.775'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.33... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changes in FiO2 affect PaO2 with minor alterations in cerebral concentration of oxygenated hemoglobin during liquid ventilation in healthy piglets. | OBJECTIVE: To measure the impact of changes in the fraction of inspired oxygen (FiO2) on systemic and cerebral oxygen supply in gas and liquid ventilated healthy animals.DESIGN: Interventional prospective animal study.SETTING: University research laboratory.PARTICIPANTS: Ten healthy, new-born piglets.INTERVENTIONS: Var... | ['Animals', 'Animals, Newborn', 'Blood Gas Analysis', 'Brain', 'Fluorocarbons', 'Liquid Ventilation', 'Oxyhemoglobins', 'Prospective Studies', 'Pulmonary Gas Exchange', 'Random Allocation', 'Swine'] | 14,722,641 | [['B01.050'], ['B01.050.050.282'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['A08.186.211'], ['D02.455.526.510.435'], ['E02.041.625.525', 'E02.880.820.525'], ['D12.776.124.400.707', 'D12.776.422.316.762.687'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. | AIMS: Heart failure is a common antecedent to atrial fibrillation; both heart failure and atrial fibrillation are associated with increased myocardial oxidative stress. Chronic canine heart failure reduces atrial action potential duration and atrial refractoriness. We hypothesized that inducible nitric oxide synthase 2... | ['Action Potentials', 'Animals', 'Arginine', 'Atrial Fibrillation', 'Atrial Function, Left', 'Biopterin', 'Cardiac Pacing, Artificial', 'Disease Models, Animal', 'Dogs', 'Female', 'Heart Atria', 'Heart Failure', 'Kinetics', 'Male', 'Myocardium', 'Nitric Oxide', 'Nitric Oxide Synthase Type II', 'Oxidative Stress', 'Patc... | 21,460,065 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['C14.280.067.198', 'C23.550.073.198'], ['G09.330.040.100'], ['D03.633.100.733.631.202', 'D08.211.090'], ['E02.331.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.3... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Remote vs. conventional navigation for catheter ablation of atrial fibrillation: insights from prospective registry data. | BACKGROUND: Robotic (RNS) or magnetic navigation systems (MNS) are available for remotely performed catheter ablation for atrial fibrillation (AF).OBJECTIVE: The present study compares remotely assisted catheter navigation (RAN) to standard manual navigation (SMN) and both systems amongst each other.METHODS: The analys... | ['Atrial Fibrillation', 'Catheter Ablation', 'Equipment Design', 'Female', 'Fluoroscopy', 'Follow-Up Studies', 'Heart Conduction System', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Registries', 'Robotics', 'Surgery, Computer-Assisted', 'Treatment Outcome'] | 30,159,751 | [['C14.280.067.198', 'C23.550.073.198'], ['E02.808.750.500', 'E04.014.760.500'], ['E05.320'], ['E01.370.350.700.225'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A07.541.409'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
Race as a Predictor of Palliative Care Referral Time, Hospice Utilization, and Hospital Length of Stay: A Retrospective Noncomparative Analysis. | BACKGROUND: Palliative care is associated with significant benefits, including reduced pain and suffering, an increased likelihood of patients dying in their preferred location, and decreased health-care expenditures. Racial and ethnic disparities are well-documented in hospice use and referral patterns; however, it is... | ['Academic Medical Centers', 'Adult', 'Aged', 'Aged, 80 and over', 'Continental Population Groups', 'Female', 'Hospice Care', 'Humans', 'Inpatients', 'Length of Stay', 'Male', 'Middle Aged', 'Palliative Care', 'Referral and Consultation', 'Retrospective Studies', 'Time Factors', 'United States', 'Urban Population', 'Yo... | 28,056,514 | [['N02.278.020'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.686.508'], ['E02.760.905.400', 'N02.421.585.905.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['E02.760.666', 'N02.421.585.666'], ['N04.452.7... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
In vitro transformation of rat bladder epithelium by 2-amino-4-(5-nitro-2-furyl)thiazole. | To establish a rat urinary bladder carcinogenesis model in vitro, primary rat bladder epithelial cells were grown in media containing 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT), the water-soluble metabolite of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT), for 4 weeks followed by long-term (4-7 months) exposure... | ['Animals', 'Carcinogens', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Drug Synergism', 'Epithelial Cells', 'Epithelium', 'FANFT', 'Female', 'Male', 'Mice', 'Mice, Inbred Strains', 'Mice, Nude', 'Neoplasm Transplantation', 'Rats', 'Rats, Inbred F344', 'Saccharin', 'Urea', 'Urinary Bladder', 'Urinary Bladder ... | 2,009,588 | [['B01.050'], ['D27.888.569.100'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['G07.690.773.968.477'], ['A11.436'], ['A10.272'], ['D02.640.600.290', 'D02.886.675.250', 'D03.383.129.708.250', 'D03.383.312.649.290'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Leflunomide, a novel immunosuppressive agent. The mechanism of inhibition of T cell proliferation. | Leflunomide is a novel immunomodulating drug that has recently been demonstrated to prevent acute rejection and reverse ongoing rejection of kidney and cardiac allografts in rats. In vitro studies here demonstrate that leflunomide suppresses proliferation of human PBL stimulated with (1) allogeneic PBL in a one-way MLR... | ['Antigens, CD', 'Antigens, Differentiation, T-Lymphocyte', 'CD28 Antigens', 'CD3 Complex', 'Cyclosporine', 'Humans', 'Immunosuppressive Agents', 'In Vitro Techniques', 'Interleukin-2', 'Isoxazoles', 'Leflunomide', 'Lymphocyte Activation', 'Lymphocyte Culture Test, Mixed', 'Receptors, Interleukin-2', 'Tetradecanoylphor... | 8,390,735 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.894', 'D23.101.100.894'], ['D12.776.543.750.705.222.500', 'D23.050.301.264.894.128', 'D23.101.100.894.128'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Co-expression network analysis and genetic algorithms for gene prioritization in preeclampsia. | BACKGROUND: In this study, we explored the gene prioritization in preeclampsia, combining co-expression network analysis and genetic algorithms optimization approaches. We analysed five public projects obtaining 1,146 significant genes after cross-platform and processing of 81 and 149 microarrays in preeclamptic and no... | ['Algorithms', 'Computational Biology', 'Female', 'Gene Regulatory Networks', 'Humans', 'Pre-Eclampsia', 'Pregnancy', 'Transcriptome'] | 24,219,996 | [['G17.035', 'L01.224.050'], ['H01.158.273.180', 'L01.313.124'], ['G05.360.080.689.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.395.249'], ['G08.686.784.769'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Two cases of inflammatory skin metastasis from transitional cell carcinoma of the urinary bladder. | Two rare cases of inflammatory skin metastasis from transitional cell carcinoma of the urinary bladder were reported. | ['Aged', 'Carcinoma, Transitional Cell', 'Dermatitis', 'Humans', 'Male', 'Skin Neoplasms', 'Urinary Bladder Neoplasms'] | 7,801,416 | [['M01.060.116.100'], ['C04.557.470.200.430'], ['C17.800.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.805', 'C17.800.882'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', 'C13.351.968.829.707']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In situ atomic force microscopy analysis of morphology and particle size changes in lithium iron phosphate cathode during discharge. | Li-ion batteries offer great promise for future plug-in hybrid electric vehicles (PHEVs) and pure electric vehicles (EVs). One of the challenges is to improve the cycle life of Li-ion batteries which requires detailed understanding of the aging phenomenon. In situ techniques are especially valuable to understand aging ... | ['Electric Power Supplies', 'Electrodes', 'Equipment Design', 'Iron', 'Lithium', 'Microscopy, Atomic Force', 'Particle Size', 'Phosphates'] | 24,703,680 | [['E07.305.124'], ['E07.305.250'], ['E05.320'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480', 'D01.552.547.290'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['G02.712'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary crystallographic studies of the amino terminal half of human lactoferrin in its iron-saturated and iron-free forms. | The amino terminal half of human lactoferrin (LfN) produced from transfected baby hamster kidney cells has been crystallized in its iron-saturated and iron-free forms. The crystals of glycosylated LfN and deglycosylated LfN are monoclinic, space group C2, with cell dimensions a = 133.0 A, b = 58.3 A, c = 58.3 A, alpha ... | ['Apoproteins', 'Cells, Cultured', 'Crystallization', 'Humans', 'Iron', 'Lactoferrin', 'Peptide Fragments', 'Recombinant Proteins', 'Transfection', 'X-Ray Diffraction'] | 1,469,729 | [['D12.776.070'], ['A11.251'], ['E05.196.300', 'G02.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D08.811.277.656.300.760.471', 'D08.811.277.656.959.350.471', 'D12.776.157.427.750.249', 'D12.776.256.159.750.816.500.507', 'D12.776.377.457.507', 'D12.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phase I clinical investigation of 7-con-O-methylnogaril, a new anthracycline antibiotic. | 7-con-O-Methylnogaril (menogaril, NSC-269148) is a new anthracycline antibiotic that has been evaluated in a Phase I clinical trial. The drug was administered in a single i.v. infusion over a period of 60 min given every 3 weeks. Twenty-four patients received 64 courses of the drug in a dose range of 16 to 256 mg/m2. G... | ['Antineoplastic Agents', 'Daunorubicin', 'Doxorubicin', 'Drug Evaluation', 'Hematopoiesis', 'Humans', 'Leukocyte Count', 'Menogaril', 'Neutrophils', 'Nogalamycin'] | 2,938,729 | [['D27.505.954.248'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.059.200'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E05.290.625', 'E05.337.425'], ['G04.152.825', 'G09.188.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.3... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-resolution powder diffraction study of purple membrane with a large Guinier-type camera. | X-ray diffraction patterns from a film of oriented purple membranes, which comprise two-dimensional crystals of bacteriorhodopsin (BR) trimers, were recorded with a 1 m-pathlength Guinier-type camera at SPring-8 BL40B2. A well focused X-ray beam and a camera with a high angular resolution of 0.024 degrees enabled a pow... | ['Equipment Design', 'Equipment Failure Analysis', 'Halobacterium salinarum', 'Image Enhancement', 'Powder Diffraction', 'Purple Membrane', 'Transducers', 'Ultrasonography'] | 16,645,256 | [['E05.320'], ['E05.325.192'], ['B02.200.400.400.410.450'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E05.196.309.711'], ['A11.284.149.648', 'A20.871'], ['E07.305.812'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The antimicrobial activity of garlic and onion extracts. | Aqueous extracts of garlic (Allium sativum) and onion (Allium cepa) were tested for activity against Gram-positive organisms, Gram-negative organisms and fungi. A significant growth inhibition was shown by most of the organisms, tested at random. A quantitative assessment of the activity was carried out by determining ... | ['Anti-Bacterial Agents', 'Bacteria', 'Garlic', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Humans', 'Microbial Sensitivity Tests', 'Mouth', 'Plant Extracts', 'Plants, Medicinal'] | 6,669,596 | [['D27.505.954.122.085'], ['B03'], ['B01.650.940.800.575.912.250.618.100.050.060.300'], ['B03.440'], ['B03.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['D20.215.784.500', 'D26.667'], ['B01.650.560']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells. | PROBLEM: Uterine natural killer cells (uNK) do not express progesterone receptor, but express glucocorticoid receptor (GR). So, we speculate that progesterone may regulate uNK cells through a GR-mediated process.METHOD OF STUDY: After mouse NK cells were stimulated with CpG with or without IL-12 in the presence or abse... | ['Animals', 'Cells, Cultured', 'CpG Islands', 'Decidua', 'Female', 'Hormone Antagonists', 'Humans', 'Interferon-gamma', 'Interleukin-12', 'Killer Cells, Natural', 'Mice', 'Mice, Inbred C57BL', 'Mifepristone', 'NF-kappa B', 'Norpregnadienes', 'Pregnancy', 'Progesterone', 'Progestins', 'Receptors, Glucocorticoid', 'Recep... | 22,380,541 | [['B01.050'], ['A11.251'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['A05.360.319.679.490.373', 'A16.710.289'], ['D06.347', 'D27.505.696.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D1... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is male fertility associated with type 2 diabetes mellitus? | OBJECTIVE: The aim of this study was to determine the prevalence of infertility in Qatari men with Diabetes Mellitus (T2DM) and to examine the association between T2DM and infertility.DESIGN: This is a cross-sectional study.SETTING: The survey was conducted at Primary Health Care Centers during a period from January 20... | ['Adult', 'Age Distribution', 'Blood Glucose', 'Causality', 'Chi-Square Distribution', 'Comorbidity', 'Confidence Intervals', 'Cross-Sectional Studies', 'Developing Countries', 'Diabetes Mellitus, Type 2', 'Humans', 'Infertility, Male', 'Life Style', 'Male', 'Middle Aged', 'Obesity', 'Odds Ratio', 'Prevalence', 'Progno... | 19,381,857 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['D09.947.875.359.448.500'], ['N05.715.350.200', 'N06.850.490.625'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.740.275', 'N05.715.360.750.220', '... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of fasting and refeeding on jejunal morphology and cellular activity in rats in relation to depletion of body stores. | BACKGROUND: Intestinal mucosa atrophy following a period of starvation characterized by the mobilization of fat stores for energy expenditure (phase II) worsen after a long fast marked by an increase in protein catabolism (phase III). However, the morphology of the jejunum is completely restored after 3 days of refeedi... | ['Animals', 'Apoptosis', 'Cell Division', 'Cell Movement', 'Eating', 'Epithelial Cells', 'Fasting', 'Intestinal Mucosa', 'Jejunum', 'Kinetics', 'Male', 'Microscopy, Electron, Scanning', 'Rats', 'Rats, Wistar', 'Recovery of Function', 'Time Factors'] | 15,223,676 | [['B01.050'], ['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['G07.203.650.283', 'G10.261.330'], ['A11.436'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684.500',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Income inequality and risk of suicide in New York City neighborhoods: a multilevel case-control study. | Evidence on the relationship between income inequality and suicide is inconsistent. Data from the New York City Office of the Chief Medical Examiner for all fatal injuries was collected to conduct a multilevel case-control study. In multilevel models, suicide decedents (n=374) were more likely than accident controls (n... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Demography', 'Female', 'Humans', 'Income', 'Male', 'Middle Aged', 'New York City', 'Residence Characteristics', 'Risk Factors', 'Socioeconomic Factors', 'Suicide, Attempted'] | 16,178,697 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['M01.060.116.630'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Design, synthesis and evaluation of a series of novel fumagillin analogues. | A series of fumagillin analogues targeted at understanding tolerability of MetAP2 toward substitution at C4 and C6 were synthesized. Initially, the C6 side chain was maintained as cinnamoyl ester and C4 was modified. It was concluded that replacing the natural C4 of fumagillin with a benzyl oxime at C4 resulted in mode... | ['Angiogenesis Inhibitors', 'Cyclohexanes', 'Drug Design', 'Drug Evaluation, Preclinical', 'Fatty Acids, Unsaturated', 'Magnetic Resonance Spectroscopy', 'Sesquiterpenes', 'Structure-Activity Relationship'] | 14,604,668 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D02.455.426.392.368.367'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.290.750', 'E05.337.550'], ['D10.251.355'], ['E05.196.867.519'], ['D02.455.849.765'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Patients' beliefs about the causes, persistence and control of psychotic experiences predict take-up of effective cognitive behaviour therapy for psychosis. | BACKGROUND: There is evidence that patients with schizophrenia benefit from standard cognitive behaviour therapy (CBT) only if active techniques are used ('full therapy'). By contrast, attending sessions but not proceeding beyond engagement and assessment strategies ('partial therapy'), or simply not attending sessions... | ['Adolescent', 'Adult', 'Aged', 'Analysis of Variance', 'Attitude to Health', 'Cognitive Behavioral Therapy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Patient Acceptance of Health Care', 'Psychiatric Status Rating Scales', 'Psychotic Disorders', 'Schizophrenia', 'Schizophrenic Psyc... | 22,781,166 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.100.150', 'N05.300.150'], ['F04.754.137.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['F01.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Establishment of rat pancreatic endocrine cell lines by infection with simian virus 40. | The feasibility of infection and transformation by SV40 (simian virus 40) of primary cell cultures derived from newborn-rat pancreas was investigated. As judged by the presence of intranuclear SV40 T-antigen, exposure to the virus resulted specifically in infection and transformation of epithelioid (predominantly endoc... | ['Animals', 'Antigens', 'Cell Line', 'Cell Transformation, Neoplastic', 'Cell Transformation, Viral', 'Clone Cells', 'Insulin', 'Islets of Langerhans', 'Peptide Biosynthesis', 'Rats', 'Simian virus 40'] | 222,255 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of an extracellular serine protease gene from the nematophagous fungus Lecanicillium psalliotae. | The gene encoding a cuticle-degrading serine protease was cloned from three isolates of Lecanicillium psalliotae (syn. Verticillium psalliotae) by 3' and 5' RACE (rapid amplification of cDNA ends) method. The gene encodes for 382 amino acids and the protein shares conserved motifs with subtilisin N and peptidase S8. Co... | ['Amino Acid Motifs', 'Ascomycota', 'Cloning, Molecular', 'Fungal Proteins', 'Genes, Fungal', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Serine Endopeptidases'] | 16,215,834 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.300.107'], ['E05.393.220'], ['D12.776.354'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['L01.453.245.667'], ['G02.111.810.200', 'G05.810.200'], ['D08.811.277.656.300.760', 'D08.811.277.656.959.350']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Treatment of radioactive liquid effluents by reverse osmosis membranes: From lab-scale to pilot-scale. | The recent use of the reverse osmosis (RO) process at the damaged Fukushima-Daiichi nuclear power plant generated a growing interest in the application of this process for decontamination purposes. This study focused on the development of a robust RO process for decontamination of two kinds of liquid effluents: a conta... | ['Filtration', 'Membranes, Artificial', 'Osmosis', 'Permeability', 'Water Purification'] | 28,675,844 | [['E05.196.454', 'G01.280', 'G02.263'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['G01.154.090.750', 'G02.111.655', 'G02.691', 'G02.723.495'], ['G02.723'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Falsely elevated lactate in severe ethylene glycol intoxication. | A 29-year-old male presented at the emergency department of our hospital in a confused state. He had a history of psychoses and substance abuse. Physical examination revealed hyperventilation and abdominal tenderness. Blood gas analysis in the emergency department using an ABL 725 Radiometer analyser showed a severe me... | ['Acidosis, Lactic', 'Adult', 'Blood Gas Analysis', 'Diagnosis, Differential', 'Ethanol', 'Ethylene Glycol', 'False Positive Reactions', 'Humans', 'Lactic Acid', 'Male', 'Psychotic Disorders', 'Renal Dialysis', 'Solvents', 'Substance-Related Disorders'] | 20,739,730 | [['C18.452.076.176.180'], ['M01.060.116'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E01.171'], ['D02.033.375'], ['D02.033.455.250.268'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459.450'], ['F03.700.675'], ['E02.870.300', 'E02.912.800'], ['D27.7... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of obesity on atrial fibrillation ablation: Patient characteristics, long-term outcomes, and complications. | BACKGROUND: There is an association between obesity and atrial fibrillation (AF). The impact of obesity on AF ablation procedures is unclear.OBJECTIVE: The purpose of this study was to evaluate the influence of body mass index (BMI) on patient characteristics, long-term ablation outcomes, and procedural complications.M... | ['Aged', 'Atrial Fibrillation', 'Body Mass Index', 'California', 'Catheter Ablation', 'Comorbidity', 'Disease Progression', 'Electrophysiologic Techniques, Cardiac', 'Female', 'Follow-Up Studies', 'Forecasting', 'Heart Atria', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Retrospective Studies', 'Sur... | 28,232,261 | [['M01.060.116.100'], ['C14.280.067.198', 'C23.550.073.198'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E02.808.750.500', 'E04.014.760.500'], ['N05.715.350.225', 'N06.850.490.687'], ['C23.550.291.656'], ['E01.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
High-throughput discovery of rare insertions and deletions in large cohorts. | Pooled-DNA sequencing strategies enable fast, accurate, and cost-effect detection of rare variants, but current approaches are not able to accurately identify short insertions and deletions (indels), despite their pivotal role in genetic disease. Furthermore, the sensitivity and specificity of these methods depend on a... | ['Computational Biology', 'Gene Frequency', 'Gene Library', 'Genotype', 'Humans', 'INDEL Mutation', 'Sensitivity and Specificity', 'Sequence Analysis, DNA', 'Software'] | 21,041,413 | [['H01.158.273.180', 'L01.313.124'], ['G05.330'], ['G05.360.325'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590.500', 'G05.558.370'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E05.393.76... | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2-year follow-up in China: An observational cohort study. | This study aimed to reveal the incidence of clinical endpoints in elderly patients with atrial fibrillation (AF) during a 2-year follow-up and evaluate the related prognostic factors of these endpoints.In total, 200 elderly patients with AF and 400 age- and sex-matched patients without AF were enrolled in this prospect... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Atrial Fibrillation', 'Body Mass Index', 'C-Reactive Protein', 'Case-Control Studies', 'China', 'Digoxin', 'Female', 'Fibrinolytic Agents', 'Follow-Up Studies', 'Hemorrhage', 'Humans', 'Male', 'Platelet Activating Factor', 'Prognosis', 'Proportional Hazards Models', 'Prospe... | 28,816,946 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.067.198', 'C23.550.073.198'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.372.500.500', 'N05.715... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Early graft failure after infrainguinal arterial bypass. | INTRODUCTION: Early graft failure (EGF), defined as failure within 30 days of an index procedure, is a serious complication after infrainguinal arterial bypass. EGF has not been examined by the use of national data since the widespread adoption of percutaneous treatments for arterial occlusive disease.METHODS: We used ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Incidence', 'Leg', 'Male', 'Middle Aged', 'Peripheral Vascular Diseases', 'Postoperative Complications', 'Retrospective Studies', 'Treatment Failure', 'United States', 'Vascular Grafting'] | 24,269,142 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['A01.378.610.500'], ['M01.060.116.630'], ['C14.907.617'], ['C23.550.767'], ['E05.318.372.500... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
PrimaTB STAT-PAK assay, a novel, rapid lateral-flow test for tuberculosis in nonhuman primates. | Tuberculosis (TB) is the most important zoonotic bacterial disease in nonhuman primates (NHP). The current diagnostic method, the intradermal palpebral tuberculin test, has serious shortcomings. We characterized antibody responses in NHP against Mycobacterium tuberculosis to identify immunodominant antigens and develop... | ['Animals', 'Antibodies, Bacterial', 'Antigens, Bacterial', 'Bacterial Proteins', 'Chlorocebus aethiops', 'Immunoassay', 'Macaca fascicularis', 'Macaca mulatta', 'Membrane Proteins', 'Mycobacterium tuberculosis', 'Primate Diseases', 'Sensitivity and Specificity', 'Tuberculin Test', 'Tuberculosis'] | 17,652,522 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D23.050.161'], ['D12.776.097'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.478.566', 'E05.601.470'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['B01.050.150.900.649.313.988.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nonplanarity of adenine: vibrational transition moment angle studies in helium nanodroplets. | Mid-infrared spectra are reported for adenine monomer in helium nanodroplets. We show that there is only one tautomer of adenine, the global minimum structure, observed in helium nanodroplets and characterized by using ab initio calculations and the measurement of vibrational transition moment angles (VTMAs) for the va... | ['Adenine', 'Amines', 'Helium', 'Isomerism', 'Nanoparticles', 'Vibration'] | 18,616,231 | [['D03.633.100.759.138'], ['D02.092'], ['D01.268.613.350', 'D01.362.641.352'], ['G02.111.570.685', 'G02.607.445'], ['J01.637.512.600'], ['G01.374.930']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A Multi-Site Study of Norovirus Molecular Epidemiology in Australia and New Zealand, 2013-2014. | BACKGROUND: Norovirus (NoV) is the major cause of acute gastroenteritis across all age groups. In particular, variants of genogroup II, genotype 4 (GII.4) have been associated with epidemics globally, occurring approximately every three years. The pandemic GII.4 variant, Sydney 2012, was first reported in early 2012 an... | ['Antigenic Variation', 'Australia', 'Caliciviridae Infections', 'Disease Outbreaks', 'Epidemiological Monitoring', 'Gastroenteritis', 'Genotype', 'Humans', 'Molecular Epidemiology', 'Mutation', 'New Zealand', 'Norovirus', 'Phylogeny', 'RNA, Viral', 'Recombination, Genetic', 'Viral Structural Proteins'] | 27,116,221 | [['G05.365.073', 'G12.500.249'], ['Z01.639.100', 'Z01.678.100.373'], ['C01.925.782.160'], ['N06.850.290'], ['E05.318.375', 'N06.850.520.460'], ['C06.405.205'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.416', 'E05.393.522', 'H01.158.201.636.475.500', 'H01.158.273.343.595.475.500', 'H01.181.... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis. | BACKGROUND: Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA methylation, which is a stable and cell type-specific regulatory epigenetic mark of genome activity,... | ['5-Methylcytosine', 'Adult', 'Aged', 'Aged, 80 and over', 'Cadaver', 'Case-Control Studies', 'Cyclic AMP Response Element-Binding Protein', 'DNA Methylation', 'Down-Regulation', 'Epigenesis, Genetic', 'Female', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Neurons', '... | 31,146,783 | [['D03.383.742.698.421.500'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.260.224'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G02.111... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stunted Growth. Proceedings of the 23rd Aschauer Soiree, Held at Aschauhof, Germany, November 7th 2015. | Twenty-four scientists met at Aschauhof, Altenhof, Germany, to discuss the associations between child growth and development, and nutrition, health, environment and psychology. Meta-analyses of body height, height variability and household inequality, in historic and modern growth studies published since 1794, highligh... | ['Adolescent', 'Age Factors', 'Body Mass Index', 'Child', 'Child, Preschool', 'Female', 'Growth Disorders', 'Humans', 'Male', 'Sex Factors'] | 27,464,419 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.715.350.675', 'N06.850.490.875']] | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. | A panel of 20 human myelin basic protein (hMBP)-specific T-lymphocyte lines was generated from the peripheral blood of eight multiple sclerosis (MS) patients and two healthy donors, most of them expressing the HLA-DR2 haplotype, which is associated with an increased susceptibility to MS. Using HLA-DR gene-transfected m... | ['Adult', 'Animals', 'Epitopes', 'Female', 'HLA-DR2 Antigen', 'Humans', 'L Cells', 'Major Histocompatibility Complex', 'Male', 'Mice', 'Multiple Sclerosis', 'Myelin Basic Protein', 'Reference Values', 'T-Lymphocytes', 'Transfection'] | 1,700,423 | [['M01.060.116'], ['B01.050'], ['D23.050.550'], ['D12.776.395.550.509.400.440.400.020', 'D12.776.543.550.440.400.440.400.020', 'D23.050.301.500.400.400.440.400.020', 'D23.050.301.500.450.400.440.389.750', 'D23.050.705.552.410.400.440.389.020', 'D23.050.705.552.450.400.440.389.750'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Use experience evaluation of Google search for obtaining medical knowledge: a case study. | More and more people use internet search engines, especially Google, to learn about diseases and possible treatments. We conducted a hallway testing to evaluate the effectiveness of Google in obtaining medical information. We searched 'Breast Cancer' using Google. Six volunteers scored their experience for each of the ... | ['Health Education', 'Humans', 'Information Dissemination', 'Information Services', 'Internet', 'Search Engine'] | 22,295,748 | [['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.443'], ['L01.453'], ['L01.224.230.110.500'], ['L01.470.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges. | BACKGROUND: Preclinical studies have shown that cocaine produces alterations in serotonergic function but our knowledge of the serotonergic alterations due to cocaine abuse in humans is still fragmentary. We therefore assessed the central serotonergic responsivity of cocaine addicts and control subjects by neuroendocri... | ['Administration, Oral', 'Adult', 'Alcoholism', 'Child of Impaired Parents', 'Cocaine-Related Disorders', 'Fathers', 'Fenfluramine', 'Genetic Predisposition to Disease', 'Humans', 'Male', 'Placebos', 'Prolactin', 'Serotonin', 'Substance-Related Disorders'] | 10,349,036 | [['E02.319.267.100'], ['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['M01.106'], ['C25.775.300', 'F03.900.300'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['D02.092.471.683.467'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
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