Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Characterizing genetic diversity of contemporary pacific chickens using mitochondrial DNA analyses. | BACKGROUND: Mitochondrial DNA (mtDNA) hypervariable region (HVR) sequences of prehistoric Polynesian chicken samples reflect dispersal of two haplogroups--D and E--by the settlers of the Pacific. The distribution of these chicken haplogroups has been used as an indicator of human movement. Recent analyses suggested sim... | ['Animals', 'Base Sequence', 'Chickens', 'DNA, Mitochondrial', 'Genetic Variation', 'Genetics, Population', 'Geography', 'Haplotypes', 'Molecular Sequence Data', 'Pacific Islands', 'Phylogeny', 'Sequence Analysis, DNA'] | 21,326,866 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D13.444.308.283.225'], ['G05.365'], ['H01.158.273.343.335'], ['H01.277.500'], ['G05.380.360'], ['L01.453.245.667'], ['Z01.639.760', 'Z01.678.100.873'], ['G05.697', 'G16.075.605', 'L... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
[Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. | OBJECTIVE: To investigate the effects of Chaihu Shugan Powder (CHSGP) on the behavior and the expressions of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptors B (TrkB) in the hippocampus, amygdala, and the frontal lobe of depression model rats.METHODS: Sixty adult Sprague-Dawley rats w... | ['Amygdala', 'Animals', 'Behavior, Animal', 'Brain-Derived Neurotrophic Factor', 'Depression', 'Frontal Lobe', 'Hippocampus', 'Male', 'Plant Extracts', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, trkB'] | 22,097,208 | [['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['B01.050'], ['F01.145.113'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['F01.145.126.350'], ['A08.186.211.200.885.287.500.270'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D20.215.784.500', '... | ['Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of allogeneic blood transfusion in patients with stage II colon cancer. | The aim of the present study was to determine whether allogeneic red blood cell transfusions showed a deleterious effect and what might be preoperative risk factors for blood transfusion in patients with TNM stage II colon cancer. Total 470 patients who fulfilled inclusion criteria were selected for a further 10-year f... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoembryonic Antigen', 'Chi-Square Distribution', 'Colonic Neoplasms', 'Erythrocyte Transfusion', 'Female', 'Follow-Up Studies', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Neoplasm Staging... | 23,534,751 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C04.588.274.476.411.307.180', 'C06.301.371.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Insulin stimulates collagen synthesis in vascular smooth muscle cells from elderly patients. | The process of aging results in an increase in collagen in arterial walls, but the blood levels of insulin-like growth factor 1 (IGF-1) decrease remarkably as adults age. There is an almost simultaneous increase in insulin secretion, particularly in obese individuals. It is not known if, under these hormonal conditions... | ['Aged', 'Aged, 80 and over', 'Aging', 'Antibodies, Monoclonal', 'Collagen', 'Female', 'Femoral Artery', 'Humans', 'Hydroxyproline', 'Insulin', 'Insulin-Like Growth Factor I', 'Male', 'Middle Aged', 'Muscle, Smooth, Vascular', 'Osmolar Concentration', 'Procollagen', 'Receptor, Insulin'] | 9,592,685 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A07.015.114.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.401.623.478'], ['D06.472.699.587.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers. | Amplification, rearrangement, or overexpression of the gene for the epidermal growth factor receptor (EGFR) occurs in certain types of human neoplasia. We investigated EGFR gene structure and measured EGFR mRNA levels in human renal tumor biopsies. Seventeen renal tumors [13 renal cell carcinomas (RCCs), two Wilms' tum... | ['Actins', 'Animals', 'Chick Embryo', 'ErbB Receptors', 'Gene Expression', 'Genes', 'Humans', 'Neoplasms', 'Proto-Oncogene Proteins', 'Proto-Oncogenes', 'RNA, Messenger', 'Receptor, ErbB-2', 'Reference Values', 'Transcription, Genetic'] | 2,572,319 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['G05.297'], ['G05.360.340.024.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['D12.77... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two independent intracranial arteriovenous malformations: a case report. | Two independent intracranial arteriovenous malformations occurring to a single patient is rarely seen. A 23-year-old female suffered from a sudden onset weakness of the left side extremities and a generalized tonic-clonic seizure. A cranial CT revealed an intracranial hemorrhage in the right posterior temporal region a... | ['Adult', 'Female', 'Humans', 'Intracranial Arteriovenous Malformations', 'Magnetic Resonance Imaging', 'Tomography, X-Ray Computed'] | 8,133,549 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.520', 'C10.500.190.500', 'C14.240.850.750.295', 'C14.240.850.875.500', 'C14.907.150.295', 'C14.907.253.560.400', 'C16.131.240.850.750.295', 'C16.131.240.850.875.500', 'C16.131.666.190.500'], ['E01.370.350.825.500'], ['E01.370.350.350.8... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sulfuric acid aerosol induces changes in alveolar surface tension in the guinea pig but not in the rat. | The purpose of this study was to investigate the effects of an acid aerosol, at high concentration, on the surface properties of the extracellular fluid lining the airways and alveolae. Guinea pigs and rats were exposed to 43 mg/m3 and 94 mg/m3 of sulfuric acid aerosol mass median aerodynamic diameter (MMAD) 0.9 micron... | ['Administration, Inhalation', 'Aerosols', 'Animals', 'Bronchoalveolar Lavage Fluid', 'Female', 'Guinea Pigs', 'Pulmonary Alveoli', 'Pulmonary Surfactants', 'Rats', 'Rats, Inbred F344', 'Species Specificity', 'Sulfuric Acids', 'Surface Tension'] | 10,352,953 | [['E02.319.267.050'], ['D20.280.055', 'D26.255.165.055'], ['B01.050'], ['E05.927.100.500'], ['B01.050.150.900.649.313.992.550'], ['A04.411.715'], ['D27.505.954.796.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.050.150.900.649.313.992.635.505.700.400.200'], ['G16.824'], ['D01.0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Craniectomy Effects on Resting State Functional Connectivity and Cognitive Performance in Immature Rats. | Experimental models have been proven to be valuable tools to understand downstream cellular mechanisms of Traumatic Brain Injury (TBI). The models allow for reduction of confounding variables and tighter control of varying parameters. It has been recently reported that craniectomy induces pro-inflammatory responses, wh... | ['Animals', 'Brain', 'Brain Injuries, Traumatic', 'Cognition', 'Craniotomy', 'Magnetic Resonance Imaging', 'Male', 'Memory, Short-Term', 'Rats', 'Rats, Sprague-Dawley'] | 30,441,561 | [['B01.050'], ['A08.186.211'], ['C10.228.140.199.444', 'C10.900.300.087.235', 'C26.915.300.200.194'], ['F02.463.188'], ['E04.525.190'], ['E01.370.350.825.500'], ['F02.463.425.540.407'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Polyphenolic compounds and antioxidant activity of new and old apple varieties. | There is considerable evidence to show that a greater intake of apple contributes to improved health by reducing the risk of diseases, such as cardiovascular disease and some forms of cancer. Apple fruit is a major source of phenol compounds, because its consumption is widespread in many countries and it is available o... | ['Antioxidants', 'Chromatography, High Pressure Liquid', 'Flavonoids', 'Fruit', 'Malus', 'Phenols', 'Polyphenols', 'Species Specificity'] | 18,611,028 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.196.181.400.300'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.859.937.500.444'], ['D02.455.426.559.389.657'], ['D02.455.426.559.389.657.715', 'D03.633.100.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The rehabilitation of patients following the surgical treatment of ischemic heart disease at a low-altitude health resort]. | We developed well grounded differentiated methods of rehabilitation treatment in low mountains for patients after surgery for ischemic heart disease. Evaluation of the results was carried out with due account for variety of clinical course of the disease, condition of coronary and myocardial reserves of the heart and c... | ['Adult', 'Aged', 'Contraindications', 'Coronary Artery Bypass', 'Health Resorts', 'Humans', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Physical Therapy Modalities', 'Postoperative Care', 'Russia'] | 9,680,814 | [['M01.060.116'], ['M01.060.116.100'], ['E02.208'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['N02.278.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647', 'C14.907.585'], ['E02.779', 'E02.831.535'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.72... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Thermodynamic basis for the genome to capsid charge relationship in viral encapsidation. | We establish an appropriate thermodynamic framework for determining the optimal genome length in electrostatically driven viral encapsidation. Importantly, our analysis includes the electrostatic potential due to the Donnan equilibrium, which arises from the semipermeable nature of the viral capsid, i.e., permeable to ... | ['Biophysical Phenomena', 'Capsid', 'Genome, Viral', 'Models, Biological', 'RNA, Viral', 'Static Electricity', 'Thermodynamics', 'Virus Assembly'] | 21,969,546 | [['G01.154'], ['A21.249.500.250'], ['G05.360.340.358.840'], ['E05.599.395'], ['D13.444.735.828'], ['G01.358.500.249.820'], ['G01.906'], ['G06.920.925.950']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In Vitro Measurement of H2 | Isolated tissue chamber bath system and wire myograph were developed for "in vitro" investigation of vasoactive responses on isolated arteries from a variety of animal species and vascular beds. The chapter characterizes the main principles of mechanical measurement of the changes in isometric tension of vascular smoot... | ['Animals', 'Aorta, Thoracic', 'Hydrogen Sulfide', 'Mesenteric Arteries', 'Muscle, Smooth, Vascular', 'Nitric Oxide', 'Rats', 'Rats, Inbred SHR', 'Rats, Wistar', 'Vasodilation'] | 31,148,108 | [['B01.050'], ['A07.015.114.056.372'], ['D01.029.260.340', 'D01.362.350', 'D01.875.350'], ['A07.015.114.565'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.3... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Parental Schoolwork Support Measure-Youth: development and psychometric evaluation. | Parental involvement in school-related tasks is associated with a number of positive outcomes across ethnic groups. However, a growing literature suggests that unique forms of involvement and barriers exist among linguistic minority Latino families. The Parental Schoolwork Support Measure-Youth (PSSM-Y) is introduced i... | ['Adolescent', 'Child', 'Factor Analysis, Statistical', 'Female', 'Hispanic Americans', 'Humans', 'Male', 'Parent-Child Relations', 'Parents', 'Poverty Areas', 'Psychometrics', 'Reproducibility of Results', 'Residence Characteristics', 'Schools', 'Social Support', 'Socioeconomic Factors', 'Students', 'Surveys and Quest... | 22,686,144 | [['M01.060.057'], ['M01.060.406'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['I01.880.853.996.535.550', 'N01.824.600.550'], ['F04.711.78... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Is the urokinase-type plasminogen activator system a reliable prognostic factor in gastric cancer? | AIM: The aim of this prospective study was to evaluate the clinical and prognostic impact of immunohistochemically assessed uPA and PAI-1 in patients with gastric cancer.METHODS: This prospective study analyzed specimens obtained from 105 gastric cancer patients who underwent gastrectomy with extended lymphadenectomy. ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Biomarkers, Tumor', 'Female', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Plasminogen Activator Inhibitor 1', 'Prognosis', 'Prospective Studies', 'Stomach Neoplasms', 'Survival Analysis', 'Urokinase-Type Plasminogen Activator'] | 17,013,798 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', '... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter. | Lysine-specific demethylase 1 (LSD1), which speci?cally demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers. We found that ectopic expression of LSD1 in cervical cancer cells promoted invasion and metastasis in vitro and in vivo, reduced the expression of the epithelial marke... | ['Animals', 'Blotting, Western', 'Carcinoma, Squamous Cell', 'Cell Line, Tumor', 'DNA Methylation', 'Epithelial-Mesenchymal Transition', 'Female', 'Gene Knockdown Techniques', 'Heterografts', 'Histone Demethylases', 'Histones', 'Humans', 'Immunohistochemistry', 'Immunoprecipitation', 'Kaplan-Meier Estimate', 'Mice', 'M... | 27,894,088 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G04.356.500'], ['E05.393.335.500'], ['A01.941... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Localization properties of multi-sensor biomagnetic systems. | The recent development of large multi-channel biomagnetic systems, with 20-30 adjacent magnetic sensors, is marking a significant progress in the detection and interpretation of biomagnetic signals, and definitely traces a new avenue towards a proper assessment of the technique in the clinical field. Several technologi... | ['Action Potentials', 'Bioelectric Energy Sources', 'Electric Conductivity', 'Electromagnetic Phenomena', 'Epilepsies, Partial', 'Epilepsy, Temporal Lobe', 'Humans', 'Noise', 'Somatosensory Cortex', 'Technology, Radiologic', 'Temporal Lobe'] | 1,814,154 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['E07.305.124.150'], ['G01.358.500.249.277'], ['G01.358.500'], ['C10.228.140.490.360'], ['C10.228.140.490.360.290', 'C10.228.140.490.493.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Association between the Density of Physicians and Suicide Rates in Japan: Nationwide Ecological Study Using a Spatial Bayesian Model. | BACKGROUND: Regional disparity in suicide rates is a serious problem worldwide. One possible cause is unequal distribution of the health workforce, especially psychiatrists. Research about the association between regional physician numbers and suicide rates is therefore important but studies are rare. The objective of ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bayes Theorem', 'Female', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Models, Biological', 'Physicians', 'Suicide'] | 26,840,389 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['E05.599.395'], ['M01.526.485.810', 'N02.360.810'], ['F01.145.126.980.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Neither L-NAME nor L-arginine changes extracellular glutamate elevation and anoxic depolarization during global ischemia and reperfusion in rat. | Both the rise in extracellular glutamate concentration and anoxic depolarization in the rat striatum during 15 min of global ischemia and reperfusion were monitored using glutamate biosensor and direct current potential electrodes, respectively. Cerebral blood flow (CBF) was simultaneously monitored with a glutamate bi... | ['Animals', 'Arginine', 'Cerebrovascular Circulation', 'Corpus Striatum', 'Electrophysiology', 'Enzyme Inhibitors', 'Extracellular Space', 'Glutamic Acid', 'Hypoxia', 'Ischemic Attack, Transient', 'Male', 'NG-Nitroarginine Methyl Ester', 'Rats', 'Rats, Wistar', 'Reperfusion Injury'] | 10,203,328 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G09.330.100.159'], ['A08.186.211.200.885.287.249.487'], ['H01.158.344.528', 'H01.158.782.236'], ['D27.505.519.389'], ['A10.082.500', 'A11.284.295'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['C23.888.852.079'], ['C10.22... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Varus and pseudoarthrosis of the upper end of the femur due to malformation]. | Congenital coxa vara with severe angulation is a difficult lesion to treat and of uncertain outcome. Many valgus osteotomies have resulted in failure because of inadequate correction or recurrence of deformity. The 27 cases described confirm this view. Out of 18 cases whose results are known, only four were good, compa... | ['Child', 'Child, Preschool', 'Female', 'Femur', 'Hip Dislocation, Congenital', 'Humans', 'Infant', 'Male', 'Osteotomy', 'Pseudarthrosis', 'Radiography'] | 3,381,003 | [['M01.060.406'], ['M01.060.406.448'], ['A02.835.232.043.150'], ['C05.660.297.500', 'C16.131.621.297.500', 'C16.131.621.449'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E04.555.580'], ['C26.404.468.627'], ['E01.370.350.700']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Histological dating of subdural hematoma in infants. | BACKGROUND: After infant deaths due to non-accidental head injury (NAHI) with subdural hematoma (SDH), the magistrates ask experts to date the traumatic event. To do so, the expert only has tools based on adult series of NAHI. We aimed to develop an SDH dating system applicable to infants aged under 3 years.METHODS AND... | ['Bilirubin', 'Child, Preschool', 'Collagen', 'Dura Mater', 'Erythrocytes', 'Female', 'Fibrin', 'Fibroblasts', 'Forensic Pathology', 'Hematoma, Subdural', 'Humans', 'Infant', 'Infant, Newborn', 'Intracranial Thrombosis', 'Lymphocytes', 'Macrophages', 'Male', 'Neovascularization, Pathologic', 'Postmortem Changes', 'Reti... | 30,554,266 | [['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['M01.060.406.448'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A08.186.566.395'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.776.124.270'], ['A11.329.228'], ['H02.403.330.300', 'H02.403.650.249', 'I0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. | Quercetin is a potent anti-inflammatory flavonoid, but its capacity to modulate insulin sensitivity in obese insulin resistant conditions is unknown. This study investigated the effect of quercetin treatment upon insulin sensitivity of ob/ob mice and its potential molecular mechanisms. Obese ob/ob mice were treated wit... | ['Animals', 'Antioxidants', 'Down-Regulation', 'Inflammation', 'Inflammation Mediators', 'Insulin', 'Male', 'Mice', 'Mice, Obese', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Quercetin', 'Up-Regulation'] | 22,713,545 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C23.550.470'], ['D23.469'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.530'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantified electroencephalographic changes in depressed patients with and without dementia. | We carried out quantified electroencephalograms (qEEG) in 17 patients with probable Alzheimer's disease (AD), who also met the DSM-III-R criteria for either dysthymia or major depression, and 18 AD patients with comparable intellectual impairment but no depression, 13 patients with depression but no AD, and 10 age-matc... | ['Aged', 'Aged, 80 and over', 'Alpha Rhythm', 'Alzheimer Disease', 'Analysis of Variance', 'Delta Rhythm', 'Depressive Disorder', 'Electroencephalography', 'Female', 'Fourier Analysis', 'Functional Laterality', 'Humans', 'Male', 'Neuropsychological Tests', 'Theta Rhythm'] | 8,555,379 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.376.300.150.374', 'E01.370.405.245.287.374', 'G07.265.087.500', 'G11.561.127.500'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.376.300.150.875', 'E01.370.405.245.287.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Contribution of systemic factors in the pathophysiology of repeated blast-induced neurotrauma. | Blast-induced traumatic brain injury is complex and involves multiple factors including systemic pathophysiological factors in addition to direct brain injuries. We hypothesize that systemic activation of platelets/leukocytes plays a major role in the development and exacerbation of brain injury after blast exposure. A... | ['Animals', 'Blast Injuries', 'Blood Platelets', 'Brain', 'Brain Injuries', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Neutrophils', 'Peroxidase', 'Platelet Glycoprotein GPIIb-IIIa Complex', 'Serotonin', 'Vasoconstriction'] | 23,370,286 | [['B01.050'], ['C26.120.126'], ['A11.118.188', 'A15.145.229.188'], ['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The predictive value of thyroid "test profile" in habitual abortion. | A characteristic thyroid test profile is observed in pregnancy; it consists of an elevated serum thyroxine (T4I), thyroxine binding globulin (TBG) and electrophoretic index (EI) with lowered triiodothyronine resin uptake (T3U), the free thyroxine index (FTI) remaining in the normal range. An investigation was made of p... | ['Abortion, Habitual', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Trimester, First', 'Thyroid Function Tests', 'Thyroxine', 'Thyroxine-Binding Proteins', 'Triiodothyronine'] | 810,157 | [['C13.703.039.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['G08.686.707.408'], ['E01.370.374.750'], ['D06.472.931.812', 'D12.125.072.050.767'], ['D12.776.124.885', 'D12.776.157.785', 'D12.776.395.832'], ['D06.472.931.740.385', 'D12.125.072.050.767.741.894']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis. | PURPOSE: Although the KRAS mutation is one of critical genetic alterations in endometrial carcinogenesis, the downstream targets are not known.EXPERIMENTAL DESIGN: In this study, we investigated the molecular targets of KRAS signals, using tumorigenic cells with oncogenic KRAS mutation established from telomerase rever... | ['Animals', 'Carcinoma', 'Cell Proliferation', 'Endometrial Neoplasms', 'Enzyme Activation', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, ras', 'Humans', 'Mice', 'Mice, Nude', 'Mutation', 'NF-kappa B', 'Neoplasm Invasiveness', 'Neoplasm Transplantation', 'Telomerase'] | 21,411,444 | [['B01.050'], ['C04.557.470.200'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['G02.111.263', 'G03.328'], ['G05.308.370'], ['G05.360.340.024.340.375.500.791.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence for a dose-dependent effect of pulsed magnetic fields on pain processing. | Functional magnetic resonance imaging (fMRI) was used to investigate the dose-response relationship (sham, 100, 200, 1000 microT) between a pulsed extremely low frequency magnetic field (ELFMF) and acute thermal pain on the dominant right hand. Forty-seven participants were recruited, and pulsed ELFMF was applied throu... | ['Acute Disease', 'Adult', 'Brain', 'Brain Mapping', 'Dose-Response Relationship, Radiation', 'Electromagnetic Fields', 'Humans', 'Magnetic Resonance Imaging', 'Pain', 'Pain Perception', 'Temperature', 'Young Adult'] | 20,643,187 | [['C23.550.291.125'], ['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['G01.358.500.260', 'G01.358.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo. | Healthy articular cartilage is thought to be maintained by the modulation of Cbfa1 expression, although little is currently known about Cbfa1 expression in such tissues. Therefore, we examined in vivo Cbfa1 transcript levels in the temporomandibular (TM) and knee joints of 3- and 10-week-old male ICR mice (weighing 50-... | ['Aging', 'Animals', 'Cartilage, Articular', 'Chondrocytes', 'Core Binding Factor Alpha 1 Subunit', 'Gene Expression', 'In Situ Hybridization', 'Knee Joint', 'Male', 'Mice', 'Mice, Inbred ICR', 'Neoplasm Proteins', 'Temporomandibular Joint', 'Transcription Factors'] | 12,798,155 | [['G07.345.124'], ['B01.050'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.329.171'], ['D12.776.930.155.200.100'], ['G05.297'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['A02.835.583.475'], ['B01.050.150.900.649.313.992.63... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characteristic expression of rice pathogenesis-related proteins in rice leaves during interactions with Xanthomonas oryzae pv. oryzae. | Pathogenesis-related (PR) proteins play an important role in the disease resistance response. To better understand the function of rice PR proteins, we examined the expressions of ten PR proteins in rice leaves at different developmental stages with or without the interaction between rice and Xanthomonas oryzae pv. ory... | ['Disease Resistance', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Oryza', 'Plant Diseases', 'Plant Leaves', 'Plant Proteins', 'Xanthomonas'] | 22,187,088 | [['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['G05.308.310'], ['G05.308.375'], ['B01.650.940.800.575.912.250.822.616'], ['G15.610'], ['A18.024.812'], ['D12.776.765'], ['B03.440.400.425.967.930', 'B03.660.250.915.930']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antimalarial effect of cyclosporin-A on murine P. berghei and human P. falciparum. | The effects of Cyclosporin-A (CsA) on the growth of Plasmodia were investigated in an experimental murine model in vivo and on human malaria in vitro. Mice were inoculated with Plasmodium berghei and then treated with different doses of CsA at the patent period. The development and course of this normally lethal parasi... | ['Animals', 'Antibodies, Protozoan', 'Cyclosporine', 'Humans', 'Malaria', 'Malaria, Falciparum', 'Mice', 'Mice, Inbred BALB C', 'Plasmodium berghei', 'Plasmodium falciparum'] | 1,915,980 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530', 'C01.920.875'], ['C01.610.752.530.650', 'C01.920.875.650'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Complementarity between medical geneticists and genetic counsellors: its added value in genetic services in Europe. | Clinical genetic services have progressed significantly the last few decades. This has led to the need for non-medical health-care professionals working as genetic counsellors in Europe and worldwide. However, there is no unified approach to genetic counsellors' role in health-care services in Europe, as in most countr... | ['Adult', 'Cooperative Behavior', 'Counselors', 'Europe', 'Female', 'Genetic Counseling', 'Genetic Testing', 'Humans', 'Male', 'Middle Aged'] | 28,513,616 | [['M01.060.116'], ['F01.145.813.115'], ['M01.526.225'], ['Z01.542'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Network meta-analysis comparing techniques and outcomes of stump closure after distal pancreatectomy. | BACKGROUND: The incidence of postoperative pancreatic fistula (POPF) after distal pancreatectomy remains high, and different pancreatic stump closure techniques have been used to reduce the incidence. A network meta-analysis was undertaken to compare the most frequently performed pancreatic stump closure techniques aft... | ['Abdominal Abscess', 'Blood Loss, Surgical', 'Hospital Mortality', 'Humans', 'Network Meta-Analysis', 'Operative Time', 'Pancreatectomy', 'Pancreatic Fistula', 'Postoperative Complications', 'Surgical Stapling', 'Suture Techniques', 'Wound Closure Techniques'] | 31,626,341 | [['C01.830.025.020'], ['C23.550.414.300', 'C23.550.505.300'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500.500', 'E05.581.500.501.500', 'N05.715.360.325.515.500', 'N06.850.520.445.500.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
DIVAN: accurate identification of non-coding disease-specific risk variants using multi-omics profiles. | Understanding the link between non-coding sequence variants, identified in genome-wide association studies, and the pathophysiology of complex diseases remains challenging due to a lack of annotations in non-coding regions. To overcome this, we developed DIVAN, a novel feature selection and ensemble learning framework,... | ['Chromatin', 'Computational Biology', 'Disease', 'Epigenomics', 'Genetic Variation', 'Genome, Human', 'Genome-Wide Association Study', 'Histone Code', 'Histones', 'Humans', 'Polymorphism, Single Nucleotide', 'Risk Factors'] | 27,923,386 | [['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['H01.158.273.180', 'L01.313.124'], ['C23.550.288'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['G05.365'], ['G05.360.340.350'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
"De novo" peptide sequencing by MALDI-quadrupole-ion trap mass spectrometry: a preliminary study. | Collision-induced dissociation of singly charged peptide ions produced by resonant excitation in a matrix-assisted laser desorption/ionization (MALDI) ion trap mass spectrometer yields relatively low complexity MS/MS spectra that exhibit highly preferential fragmentation, typically occurring adjacent to aspartyl, gluta... | ['Amino Acid Sequence', 'Electrophoresis, Polyacrylamide Gel', 'Expressed Sequence Tags', 'Molecular Sequence Data', 'Peptide Mapping', 'Peptides', 'Pinus', 'Plant Proteins', 'Sequence Analysis, Protein', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 12,954,169 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.401.402', 'E05.301.300.319'], ['G05.360.340.024.340.137.275'], ['L01.453.245.667'], ['E05.196.181.400.454.720', 'E05.196.401.319.720', 'E05.196.700', 'E05.393.760.705.685'], ['D12.644'], ['B01.650.940.800.575.912.625.875.777'], ['D12.776.765'], ['E05.393.760.705'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Slimgraft: a percutaneous endovascular graft system. | PURPOSE: To describe an in vitro feasibility trial of a new percutaneous endograft delivery technique.METHODS AND RESULTS: A water flow model of 9-mm (inner diameter) transparent plastic tubing was used to test the feasibility of sequentially delivering the components of an endograft through a 7-F sheath for assembly i... | ['Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Feasibility Studies', 'Humans', 'In Vitro Techniques', 'Models, Cardiovascular', 'Prosthesis Design', 'Stents'] | 10,772,748 | [['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.599.395.161'], ['E05.320.550', 'E07.695.680'], ['E07.695.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Polymorphisms of DNA repair gene XPD and DNA damage of workers exposed to vinylchloride monomer. | Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. 2-Chloroethylene oxide (CEO) and 2-chloroacetaldehyde (CAA), the metabolic intermediates of VCM, induce DNA damage which is mainly repaired by the nucleotide excision repair (NER) pathway. The XPD gene pr... | ['Adult', 'Air Pollutants, Occupational', 'Carcinogens', 'Case-Control Studies', 'China', 'DNA Damage', 'DNA Repair', 'Female', 'Genotype', 'Humans', 'Inhalation Exposure', 'Liver', 'Male', 'Middle Aged', 'Occupational Exposure', 'Polymorphism, Genetic', 'Vinyl Chloride'] | 16,217,922 | [['M01.060.116'], ['D27.888.284.101.268'], ['D27.888.569.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474.164'], ['G05.200'], ['G02.111.222', 'G05.219'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.112'], ['A03.620'], ['M01.060.116.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Synergistic Capsicum-tea mixtures with anticancer activity. | We have demonstrated a synergy between a decaffeinated green tea concentrate and a vanilloid-containing Capsicum preparation obtained commercially. At a ratio of 25 parts green tea concentrate to 1 part Capsicum preparation, the resultant product exhibited efficacy in the killing of cancer cells in culture 100-times th... | ['Antineoplastic Agents, Phytogenic', 'Beverages', 'Capsicum', 'Catechin', 'Cell-Free System', 'Drug Synergism', 'HeLa Cells', 'Humans', 'Inhibitory Concentration 50', 'NADH, NADPH Oxidoreductases', 'Plant Extracts', 'Tea'] | 12,906,756 | [['D27.505.954.248.179'], ['G07.203.100', 'J02.200'], ['B01.650.940.800.575.912.250.908.500.145'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['A11.284.835.168'], ['G07.690.773.968.477'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. | The substance P receptor (SPR) is a G protein-coupled receptor (GPCR) that plays a key role in pain regulation. The SPR desensitizes in the continued presence of agonist, presumably via mechanisms that implicate G protein-coupled receptor kinases (GRKs) and beta-arrestins. The temporal relationship of these proposed bi... | ['Arrestins', 'Biological Transport', 'Cell Line', 'Cell Membrane', 'Cyclic AMP-Dependent Protein Kinases', 'Cytoplasm', 'Humans', 'Neurokinin-1 Receptor Antagonists', 'Protein Kinase C', 'Receptors, Neurokinin-1', 'Substance P', 'beta-Adrenergic Receptor Kinases', 'beta-Arrestin 2', 'beta-Arrestins'] | 10,066,824 | [['D12.644.360.024.098', 'D12.776.157.057.005', 'D12.776.306.090', 'D12.776.476.024.104', 'D12.776.543.090'], ['G03.143'], ['A11.251.210'], ['A11.284.149'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['A11.284.430.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Inappropriate secretion of antidiuretic hormone (ISADH) after head injury (author's transl)]. | Two new observations of ISADH following head injury are described. A review of the medical literature is presented. Reports of ISADH after head injury are rare in comparison to the frequent occurrence of hydroelectrolytic disorders in the same situation. Attention is drawn to misleading clinical pictures, suggestive of... | ['Aged', 'Craniocerebral Trauma', 'Demeclocycline', 'Female', 'Humans', 'Hyponatremia', 'Inappropriate ADH Syndrome', 'Male'] | 6,285,495 | [['M01.060.116.100'], ['C10.900.300', 'C26.915.300'], ['D02.455.426.559.847.562.900.185', 'D04.615.562.900.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.950.620'], ['C10.228.140.617.738.320', 'C18.452.950.626', 'C19.700.490']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
D-dimer for the exclusion of venous thromboembolism: comparison of a new automated latex particle immunoassay (MDA D-dimer) with an established enzyme-linked fluorescent assay (VIDAS D-dimer). | The use of D-dimer tests to exclude venous thromboembolism is an important advance in clinical practice and also has economic benefits. Ideally the test should be objective and a test that could be run on the routine coagulometer would obviate the need for additional investment in alternative hardware. A new automated ... | ['Enzyme-Linked Immunosorbent Assay', 'Fibrin Fibrinogen Degradation Products', 'Humans', 'Immunoassay', 'Sensitivity and Specificity', 'Venous Thrombosis'] | 10,646,079 | [['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Induction of the Escherichia coli cytochrome d by low delta mu H+ and by sodium ions. | Regulation of synthesis of cytochrome d in Escherichia coli has been studied using mutants with cytochrome-d--beta-galactosidase gene fusions. It was shown that various protonophorous uncouplers, when added to the growth medium, cause induction of the cytochrome d synthesis. The cytochrome-d-inducing activity of uncoup... | ['Cytochrome d Group', 'Enzyme Induction', 'Escherichia coli', 'Hydrogen', 'Ions', 'Mutation', 'Recombinant Fusion Proteins', 'Sodium', 'beta-Galactosidase'] | 7,556,165 | [['D08.244.300', 'D12.776.422.220.300'], ['G05.308.320.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D01.268.406', 'D01.362.340'], ['D01.248.497'], ['G05.365.590'], ['D12.776.828.300'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['D08.811.277.450.410.100']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. | Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination in B cells by deaminating C --> U on transcribed DNA. Here we analyze the role of phosphorylation and phosphorylation-null mutants on the biochemical behavior of AID, including enzyme specific activity, processivi... | ['Amino Acid Motifs', 'Animals', 'Cell Line', 'Cytidine Deaminase', 'DNA', 'DNA Mutational Analysis', 'DNA, Single-Stranded', 'Humans', 'Insecta', 'Mass Spectrometry', 'Models, Biological', 'Mutation', 'Phosphorylation', 'Serine', 'Transcription, Genetic'] | 18,417,471 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['A11.251.210'], ['D08.811.277.151.486.250'], ['D13.444.308'], ['E05.393.760.700.300'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.617'], ['E05.196.566... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential clinical features and long-term prognosis of acute aortic syndrome according to disease entity. | AIMS: To evaluate the acute and long-term prognosis of acute aortic syndrome (AAS) according to the disease entity [intramural haematoma (IMH) vs. aortic dissection (AD)] and the anatomical location (type A vs. B).METHODS AND RESULTS: A total of 1012 patients [672 with AD and 340 with IMH (33.6%)] were enrolled between... | ['Aged', 'Aneurysm, Dissecting', 'Aortic Diseases', 'Female', 'Hematoma', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'Treatment Outcome'] | 31,220,232 | [['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.109'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Highly Efficient Targeted Gene Editing in Upland Cotton Using the CRISPR/Cas9 System. | The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) gene editing system has been shown to be able to induce highly efficient mutagenesis in the targeted DNA of many plants, including cotton, and has become an important tool for investigation of gene function and crop ... | ['Base Sequence', 'CRISPR-Associated Protein 9', 'CRISPR-Cas Systems', 'Gene Editing', 'Genes, Plant', 'Genetic Vectors', 'Gossypium', 'Mutagenesis', 'Mutation', 'Plants, Genetically Modified', 'RNA, Guide'] | 30,275,376 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.352.355.325.150', 'D12.776.097.219', 'D12.776.212.500'], ['G05.308.203.374.394'], ['E05.393.420.270'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.360.337'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['G05.558'], ['G05.365.59... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
FOETAL for NCD-FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania. | PURPOSE: Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns' risk of NCDs may provide approaches to prevent NCDs.PARTICIPANTS: The ... | ['Adult', 'Anemia', 'Child Development', 'Epidemiological Monitoring', 'Epigenomics', 'Female', 'Health Services Needs and Demand', 'Humans', 'Infant, Newborn', 'Malaria', 'Noncommunicable Diseases', 'Preconception Care', 'Pregnancy', 'Pregnancy Complications, Hematologic', 'Prenatal Exposure Delayed Effects', 'Risk As... | 31,122,967 | [['M01.060.116'], ['C15.378.071'], ['F01.525.200', 'G07.345.374.750'], ['E05.318.375', 'N06.850.520.460'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C01.610.752.530', 'C01.920.875'], ['C23.550.291.8... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Genomic diversification of marine cyanophages into stable ecotypes. | Understanding the structure and origin of natural bacteriophage genomic diversity is important in elucidating how bacteriophages influence the mortality rates and composition of their host communities. Here, we examine the genetic structure and genomic diversification of naturally occurring bacteriophages by analyzing ... | ['Bacteriophages', 'Ecotype', 'Genome, Viral', 'Genomics', 'New England', 'Seawater', 'Synechococcus'] | 27,696,643 | [['B04.123'], ['G05.695.200', 'G16.500.275.157.049.230', 'N06.230.124.049.230'], ['G05.360.340.358.840'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['Z01.107.567.875.550'], ['G16.500.275.725.500'], ['B03.280.745', 'B03.440.475.100.745']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Anti-inflammatory and anti-fibrotic effects of annexin1 on erectile function after cavernous nerve injury in rats. | The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crus... | ['Animals', 'Annexin A1', 'Anti-Inflammatory Agents', 'Disease Models, Animal', 'Erectile Dysfunction', 'Male', 'Nerve Crush', 'Penile Erection', 'Penis', 'Peripheral Nerve Injuries', 'Rats', 'Rats, Wistar', 'Tumor Necrosis Factor-alpha', 'Vascular Endothelial Growth Factor A'] | 27,557,611 | [['B01.050'], ['D12.776.157.125.050.050'], ['D27.505.954.158'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C12.294.644.486', 'F03.835.400'], ['E04.525.210.560'], ['G08.686.784.717'], ['A05.360.444.492'], ['C10.668.829.712', 'C10.900.575', 'C26.915.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predictors of prolonged fluoroscopy time in diagnostic coronary angiography. | BACKGROUND: Prolonged fluoroscopy time during coronary angiography is a major concern for interventional cardiologists as well as for patients. It is unknown which factors affect the prolonged fluoroscopy time.METHODS: A total of 458 patients who underwent diagnostic coronary angiography were included. The patients who... | ['Aged', 'Aorta', 'Aortic Valve Insufficiency', 'Coronary Angiography', 'Female', 'Fluoroscopy', 'Heart', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Risk Factors', 'Time Factors'] | 26,995,497 | [['M01.060.116.100'], ['A07.015.114.056'], ['C14.280.484.048.500'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['E01.370.350.700.225'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phylogenetic comparison of classical swine fever virus in China. | An N-terminal fragment of the E2 gene of classical swine fever (CSF) virus encoding major immunogenic sites was amplified by RT-PCR directly from 110 clinical specimens representing 109 epizootic sites during the last decade in China. Phylogenetic relationships between these viruses as well as 20 reference strains were... | ['Animals', 'China', 'Classical Swine Fever', 'Classical Swine Fever Virus', 'DNA, Viral', 'Molecular Epidemiology', 'Phylogeny', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Analysis, DNA', 'Swine', 'Viral Envelope Proteins'] | 11,682,122 | [['B01.050'], ['Z01.252.474.164'], ['C01.925.782.350.675.200', 'C22.905.170'], ['B04.820.578.344.700.125'], ['D13.444.308.568'], ['E05.318.416', 'E05.393.522', 'H01.158.201.636.475.500', 'H01.158.273.343.595.475.500', 'H01.181.122.650.475.550', 'H02.403.720.500.300', 'N06.850.520.470'], ['G05.697', 'G16.075.605', 'L01.... | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Bacillary angiomatosis of the anterior orbit, eyelid, and conjunctiva. | PURPOSE: To report a case of bacillary angiomatosis of the lower eyelid, conjunctiva, and anterior orbit.DESIGN: Interventional case report.METHODS: A 76-year-old immunocompromised male patient developed a firm vascularized nodule in his left lower eyelid and anterior orbit.RESULTS: An excisional biopsy was performed. ... | ['Aged', 'Angiomatosis, Bacillary', 'Anti-Bacterial Agents', 'Bartonella quintana', 'Conjunctival Diseases', 'Doxycycline', 'Drug Therapy, Combination', 'Eye Infections, Bacterial', 'Eyelid Diseases', 'Humans', 'Immunocompromised Host', 'Male', 'Orbital Diseases', 'Rifampin'] | 12,208,256 | [['M01.060.116.100'], ['C01.150.252.400.126.100.075', 'C01.150.252.819.150', 'C01.800.720.150', 'C14.907.077.060', 'C17.800.838.765.150', 'C17.800.862.060'], ['D27.505.954.122.085'], ['B03.440.090.100.650', 'B03.660.050.030.040.650'], ['C11.187'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['E02.319.31... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro and in vivo analysis of the biodegradable behavior of a magnesium alloy for biomedical applications. | The present study was designed to investigate the biodegradation behavior of Mg alloy plates in the maxillofacial region. For in vitro analysis, the plates were immersed in saline solution and simulated body fluid. For in vivo, the plates were implanted into the tibia, head, back, abdominal cavity, and femur and assess... | ['Abdominal Cavity', 'Alloys', 'Animals', 'Biocompatible Materials', 'Body Fluids', 'Corrosion', 'Femur', 'Implants, Experimental', 'Internal Fixators', 'Jaw Fractures', 'Magnesium', 'Microscopy, Electron, Scanning', 'Random Allocation', 'Rats', 'Rats, Wistar', 'Sodium Chloride', 'Spectrometry, X-Ray Emission', 'Tibia'... | 30,158,349 | [['A01.923.047.025'], ['D01.552.033', 'D25.058', 'J01.637.051.058'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A12.207'], ['G02.165'], ['A02.835.232.043.150'], ['E07.695.340'], ['E07.695.370', 'E07.858.442.660.460', 'E07.858.690.725.460'], ['C10.900.300.284.500.400', 'C26.404.750.467', 'C26.915.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Chronic Kidney Disease Stage Progression in Patients Undergoing Repair of Persistent Cloaca. | PURPOSE: Children born with persistent cloaca undergo complex pelvic reconstruction early in life. Long-term risks of bladder dysfunction and chronic kidney disease are well described. We report upper urinary tract outcomes and the risk of chronic kidney disease stage progression in this patient population.MATERIALS AN... | ['Cloaca', 'Disease Progression', 'Humans', 'Infant', 'Renal Insufficiency, Chronic', 'Retrospective Studies', 'Severity of Illness Index'] | 25,623,743 | [['A13.223', 'A16.178'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C12.777.419.780.750', 'C13.351.968.419.780.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Recreational drugs and sexual behavior in the Chicago MACS/CCS cohort of homosexually active men. Chicago Multicenter AIDS Cohort Study (MACS)/Coping and Change Study. | Since initial reports emerged of an association between recreational drug use and high-risk sexual behaviors in gay men, there has been interest in studying this relationship for its relevance to behavioral interventions. Reported here are the longitudinal patterns of alcohol and recreational drug use in the Chicago Mu... | ['Acquired Immunodeficiency Syndrome', 'Adaptation, Psychological', 'Adult', 'Alcohol Drinking', 'Amyl Nitrite', 'Chicago', 'Cohort Studies', 'Cross-Sectional Studies', 'Homosexuality', 'Humans', 'Illicit Drugs', 'Longitudinal Studies', 'Male', 'Marijuana Abuse', 'Prospective Studies', 'Psychotropic Drugs', 'Risk-Takin... | 7,910,500 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['F01.058'], ['M01.060.116'], ['F01.145.317.269'], ['D02.633.025'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['E05... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Multiple estrogen receptor assays in human breast cancer. | A review of assay results from more than 6000 patients revealed 232 patients in whom multiple breast cancer specimens were analyzed for estrogen receptor (ER). All assays were performed in a single laboratory. Specimens were considered estrogen receptor positive (ER+) if the ER level was greater than 10 fmol/mg protein... | ['Adult', 'Aged', 'Biopsy', 'Breast Neoplasms', 'Female', 'Humans', 'Middle Aged', 'Receptors, Estrogen'] | 6,847,780 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.826.750.350', 'D12.776... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. | ABCA1 plays a major role in HDL metabolism. Cholesterol secretion by ABCA1 is dependent on the presence of extracellular acceptors, such as lipid-free apolipoprotein A-I (apoA-I). However, the importance of the direct interaction between apoA-I and ABCA1 in HDL formation remains unclear. In contrast, ABCB4 mediates the... | ['ATP Binding Cassette Transporter 1', 'ATP-Binding Cassette Transporters', 'Amino Acid Substitution', 'Apolipoprotein A-I', 'Biological Transport, Active', 'Cell Line', 'Cell Membrane', 'Cholesterol', 'Humans', 'Kinetics', 'Lipid Metabolism', 'Mutation, Missense', 'Phospholipids', 'Protein Binding', 'Tangier Disease',... | 19,202,195 | [['D12.776.157.530.100.050.500', 'D12.776.395.550.020.381.500', 'D12.776.543.550.192.381.500', 'D12.776.543.585.100.190.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['E05.393.420.601.035', 'G05.558.109'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and evaluation of diffusive gradients in thin films based on nano-sized zinc oxide particles for the in situ sampling of tetracyclines in pig breeding wastewater. | The pollution of antibiotics, including tetracyclines (TCs), in aquatic environments has become an issue of concern in recent years. Herein, an in situ sampling of TCs in pig breeding wastewater that utilizes the technique of diffusive gradients in thin films (DGT), based on commercial nanosized ZnO (nanoZnO) particles... | ['Animal Husbandry', 'Animals', 'Anti-Bacterial Agents', 'Chlortetracycline', 'Diffusion', 'Environmental Monitoring', 'Membranes, Artificial', 'Metal Nanoparticles', 'Oxytetracycline', 'Polymers', 'Sulfones', 'Sus scrofa', 'Tetracycline', 'Waste Water', 'Water Pollutants, Chemical', 'Zinc Oxide'] | 30,312,908 | [['J01.040.090'], ['B01.050'], ['D27.505.954.122.085'], ['D02.455.426.559.847.562.900.146', 'D04.615.562.900.146'], ['G01.202', 'G02.196'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['J01.637.512.600.500'], ['D02.455.426.559.847.562.900.600', 'D04.615.562.900.600'], ... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Prevalence and genetic characterization of shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh. | To determine the prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) in slaughter animals in Dhaka, Bangladesh, we collected rectal contents immediately after animals were slaughtered. Of the samples collected from buffalo (n = 174), cows (n = 139), and goats (n = 110), 82.2%, 72.7%, and 11.8% tested posi... | ['Abattoirs', 'Animals', 'Bacteriophage Typing', 'Bangladesh', 'Buffaloes', 'Cattle', 'Cattle Diseases', 'DNA, Bacterial', 'Disease Reservoirs', 'Electrophoresis, Gel, Pulsed-Field', 'Escherichia coli Infections', 'Feces', 'Food Microbiology', 'Genes, Bacterial', 'Goat Diseases', 'Goats', 'Meat', 'Prevalence', 'Serotyp... | 18,641,151 | [['J01.576.423.200.700.100', 'J03.540.020'], ['B01.050'], ['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['Z01.252.245.131'], ['B01.050.150.900.649.313.500.380.135'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['D13.444.308.212'], ['N06.850.520.203.250'], ['E05.196.401.220', 'E05.301.300.220'], ... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Estimation of Survival Probabilities for Use in Cost-effectiveness Analyses: A Comparison of a Multi-state Modeling Survival Analysis Approach with Partitioned Survival and Markov Decision-Analytic Modeling. | Modeling of clinical-effectiveness in a cost-effectiveness analysis typically involves some form of partitioned survival or Markov decision-analytic modeling. The health states progression-free, progression and death and the transitions between them are frequently of interest. With partitioned survival, progression is ... | ['Antineoplastic Combined Chemotherapy Protocols', 'Cost-Benefit Analysis', 'Data Interpretation, Statistical', 'Decision Support Techniques', 'Disease-Free Survival', 'Humans', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Markov Chains', 'Probability', 'Quality-Adjusted Life Years', 'Survival Analysis'] | 27,698,003 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['N03.219.151.125'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.245', 'L01.313.500.750.190'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Synthesis and anticonvulsant activity of some amino acid derivatives. Part 1: alanine derivatives. | Fifteen amides of N-substituted D-Ala, DL-Ala and beta Ala have been designed and synthesized as potential anticonvulsants. All obtained amides as well as one intermediate (8) were evaluated in the maximal electroshock seizure (MES) test, the subcutaneous Metrazol seizure threshold (sc Met) test and the rotorod neuroto... | ['Acetylation', 'Alanine', 'Animals', 'Anticonvulsants', 'Chemical Phenomena', 'Chemistry, Physical', 'Convulsants', 'Electroshock', 'Gait', 'Injections, Intraperitoneal', 'Mice', 'Orientation', 'Pentylenetetrazole', 'Postural Balance', 'Rats', 'Seizures'] | 8,900,864 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['D12.125.042'], ['B01.050'], ['D27.505.954.427.080'], ['G02'], ['H01.181.529'], ['D27.505.696.282.224', 'D27.505.954.427.220.224'], ['E05.723.402.403', 'F04.669.224'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['E02.319.267.530.490'], ['B01.050.150.900.649.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
RNA polymerase pausing regulates translation initiation by providing additional time for TRAP-RNA interaction. | RNA polymerase (RNAP) pause sites have been identified in several prokaryotic genes. Although the presumed biological function of RNAP pausing is to allow synchronization of RNAP position with regulatory factor binding and/or RNA folding, a direct causal link between pausing and changes in gene expression has been diff... | ['Bacillus subtilis', 'Bacterial Proteins', 'Binding Sites', 'Cells, Cultured', 'DNA-Directed RNA Polymerases', 'Gene Expression Regulation, Bacterial', 'Models, Biological', 'Operon', 'Prokaryotic Initiation Factors', 'Protein Binding', 'RNA, Messenger', 'RNA-Binding Proteins', 'Time Factors', 'Transcription Factors',... | 17,114,058 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['G02.111.570.120'], ['A11.251'], ['D08.811.913.696.445.735.270'], ['G05.308.300'], ['E05.599.395'], ['G05.360.340.024.686', 'G05.360.340.358.207.500'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip. | A hybrid circuit of a semiconductor chip and synaptically connected neurons was implemented and characterized. Individual nerve cells from the snail Lymnaea stagnalis were immobilized on a silicon chip by microscopic picket fences of polyimide. The cells formed a network with electrical synapses after outgrowth in brai... | ['Animals', 'Cell Division', 'Cells, Cultured', 'Cells, Immobilized', 'Electrophysiology', 'In Vitro Techniques', 'Lymnaea', 'Microscopy, Electron, Scanning', 'Neurobiology', 'Neurons', 'Semiconductors', 'Signal Transduction', 'Synapses'] | 11,526,244 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A11.270'], ['H01.158.344.528', 'H01.158.782.236'], ['E05.481'], ['B01.050.500.644.400.750.645'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['H01.158.273.610', 'H01.158.610.080'], ['A08.675', 'A11.671'], ['E07.30... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Proton nuclear magnetic resonance analyses of the molecular conformations of unique long neurotoxins bearing Phe-25: Astrotia stokesii b, Astrotia stokesii c, and Acanthophis antarcticus b. | The 270-MHz proton NMR spectra of the unique long neurotoxins bearing Phe-25, Astrotia stokesii b (As b) and Astrotia stokesii c (As c) from Astrotia stokesii, and Acanthophis antarcticus b (Aa b) from Acanthophis antarcticus, have been analyzed. The aromatic proton resonances of Phe-25 in As b and Aa b were assigned o... | ['Circular Dichroism', 'Elapid Venoms', 'Hydrogen-Ion Concentration', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Neurotoxins', 'Phenylalanine', 'Tryptophan'] | 3,711,042 | [['E05.196.867.151'], ['D20.888.850.325', 'D23.946.833.850.325'], ['G02.300'], ['E05.196.867.519'], ['G02.111.570.820'], ['D27.888.569.504'], ['D12.125.072.050.685', 'D12.125.142.666'], ['D12.125.072.050.850', 'D12.125.142.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamic of total internal reflection (2+1)D bright beams on photorefractive SBN61:Ce crystal. | We study experimentally and numerically the transient behavior of a (2+1)D beam when it is totally reflected by nonlinear interface formed by SBN61:Ce photorefractive crystal. The dynamics give rise to observation of new beams. Due to modulation instability of the beam, the nonlinear interface stimulates the break of t... | ['Cerium', 'Lasers, Gas', 'Nonlinear Dynamics', 'Optics and Photonics', 'Refractometry'] | 22,274,420 | [['D01.268.558.362.249', 'D01.552.550.399.249'], ['E07.632.490.367', 'E07.710.520.367'], ['E05.599.850', 'H01.548.675'], ['H01.671.617', 'J01.293.688'], ['E05.196.808', 'H01.671.617.755']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Production of enantiomerically pure (S)-beta-phenylalanine and (R)-beta-phenylalanine by penicillin G acylase from Escherichia coli in aqueous medium. | A new approach has been developed for the production of enantiomerically pure (S)-beta-phenylalanine (S-BPA) and (R)-beta-phenylalanine in aqueous medium based on enantioselective acylation and hydrolysis properties of penicillin G acylase from Escherichia coli. The acylation reaction was highly preferential for the ac... | ['Acetanilides', 'Acylation', 'Enzyme Stability', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Penicillin Amidase', 'Phenylalanine', 'Stereoisomerism', 'Substrate Specificity', 'Temperature', 'Time Factors'] | 17,657,412 | [['D02.065.199.092', 'D02.092.146.113.092'], ['G02.111.012', 'G02.607.063', 'G03.040'], ['E05.916.360', 'G02.111.700.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.300'], ['D08.811.277.087.690'], ['D12.125.072.050.685', 'D12.125.142.666'], ['G02.607.445.682'], ['G02.111.835'], ['G01.906.595', 'G16... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synergistic effect of amantadine and imipramine in the forced swimming test. | The obtained results indicate that joint administration of amantadine (a non-competitive NMDA receptor antagonist) and imipramine induced antidepressant-like effect in the forced swimming test even at doses of both drugs which were ineffective when each of the drugs was used alone. | ['Amantadine', 'Animals', 'Antidepressive Agents, Tricyclic', 'Behavior, Animal', 'Drug Synergism', 'Excitatory Amino Acid Antagonists', 'Exploratory Behavior', 'Imipramine', 'Male', 'Rats', 'Rats, Wistar', 'Receptors, N-Methyl-D-Aspartate', 'Swimming'] | 10,949,113 | [['D02.455.426.100.050.035'], ['B01.050'], ['D27.505.954.427.700.122.055'], ['F01.145.113'], ['G07.690.773.968.477'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['F01.145.387', 'F01.658.370'], ['D03.633.300.240.485'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.90... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Na (+) /Ca (2+) Exchanger 3 is Downregulated in the Hippocampus and Cerebrocortex of Rats with Hyperthermia-induced Convulsion. | BACKGROUND: Na + /Ca 2+ exchanger (NCX) plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we examined the potential changes in NCX3 in the hippocampus and cerebrocortex of rats with hyperthermia-indu... | ['Animals', 'Cerebral Cortex', 'Down-Regulation', 'Female', 'Fever', 'Hippocampus', 'Pregnancy', 'Rats', 'Rats, Sprague-Dawley', 'Seizures', 'Sodium-Calcium Exchanger'] | 26,608,990 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C23.888.119.344'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['C10.597.742', 'C23.888.5... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Amanita mushroom poisoning: efficacy of aggressive treatment of two dogs. | Amatoxins, the primary toxins found in mushrooms of the genus Amanita, are very toxic to dogs. Acute fulminant liver failure and death can occur within a few days of ingestion. By their curious nature, dogs, especially young dogs, are prone to ingest mushrooms. Early identification of suspect mushrooms, and prompt emer... | ['Amanita', 'Animals', 'Dog Diseases', 'Dogs', 'Fatal Outcome', 'Female', 'Hemoperfusion', 'Male', 'Mushroom Poisoning'] | 11,931,514 | [['B01.300.179.100.110'], ['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['E02.870.244', 'E02.912.430', 'E04.292.510'], ['C25.723.415.551', 'C25.723.680.551']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Defining a pulmonary exacerbation in cystic fibrosis. | OBJECTIVES: Despite the central importance of pulmonary exacerbations (PExs) as an outcome measure in cystic fibrosis clinical trials, no standardized definition of PEx exists. We conducted a prospective, multicenter study to establish a standardized PEx definition and score for use in clinical trials, based on clinica... | ['Administration, Inhalation', 'Adult', 'Anti-Bacterial Agents', 'Cystic Fibrosis', 'Female', 'Humans', 'Lung Diseases', 'Male', 'Maximal Expiratory Flow Rate', 'Multicenter Studies as Topic', 'ROC Curve', 'Randomized Controlled Trials as Topic', 'Surveys and Questionnaires', 'Tobramycin'] | 11,562,614 | [['E02.319.267.050'], ['M01.060.116'], ['D27.505.954.122.085'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E01.370.386.700.660.225.500', 'G09.772.650.300.590'], ['E05.318.372.658', 'N05.715.360.330.643', 'N06.850.520.450.643'], ['E05.318... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of transgenerational immune priming on the defence of insect eggs against parasitism. | Insects are known to prime the immune state of their offspring. However, although the beginning of insect life, the egg stage, is often greatly endangered by parasitism, no knowledge is available regarding whether transgenerational immune priming improves the immune responses of insect eggs to actual parasitoid attacks... | ['Animals', 'Female', 'Hemolymph', 'Host-Parasite Interactions', 'Immunity', 'Larva', 'Life Cycle Stages', 'Male', 'Manduca', 'Micrococcus luteus', 'Monophenol Monooxygenase', 'Ovum', 'Peptidoglycan', 'Wasps'] | 25,790,896 | [['B01.050'], ['A13.453'], ['G16.527.200.400'], ['G12.450'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B05.500', 'G07.345.500.550.500'], ['B01.050.500.131.617.720.500.500.937.650.525'], ['B03.510.024.850.500.500', 'B03.510.400.500.500.400'], ['D08.811.682.690.708.125.500'], ['A05.360.490.690', 'A11.497.497', 'A16.6... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption. | Oridonin (Ori) is a natural compound with notable anti-inflammation and anti-cancer activities. However, therapeutic use of this compound is limited by its poor solubility and low bioavailability. Here a novel biotin-modified nanostructured lipid carrier (NLC) was developed to enhance the bioavailability of Ori. The ef... | ['Administration, Oral', 'Animals', 'Antineoplastic Agents, Phytogenic', 'Biological Availability', 'Biotin', 'Diterpenes, Kaurane', 'Drug Carriers', 'Drug Delivery Systems', 'Intestinal Absorption', 'Ligands', 'Lipids', 'Nanostructures', 'Permeability', 'Rats', 'Rats, Sprague-Dawley', 'Solubility'] | 25,556,104 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.248.179'], ['G03.787.151', 'G07.690.725.129'], ['D03.383.129.308.080', 'D08.211.096'], ['D02.455.849.291.239'], ['D26.255.260', 'E02.319.300.380'], ['E02.319.300'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparative transcriptome analysis to elucidate the therapeutic mechanism of colchicine against atrial fibrillation. | In recent years, colchicine has been used to reduce the risk of cardiovascular events; in particular, it has been effectively used for the treatment of atrial fibrillation (AF). We first discovered that colchicine can treat AF in a rat model and that it can reverse the effects of atrial fibrosis. To illustrate the pote... | ['Animals', 'Atrial Fibrillation', 'Colchicine', 'Disease Models, Animal', 'Down-Regulation', 'Electrocardiography', 'Gene Expression Profiling', 'Gene Ontology', 'Heart Atria', 'Rats, Sprague-Dawley', 'Transcriptome', 'Up-Regulation'] | 31,514,070 | [['B01.050'], ['C14.280.067.198', 'C23.550.073.198'], ['D03.132.225'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E05.393.332'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
NADPH mediates the inactivation of bovine liver catalase by monochloroamine. | Bovine liver catalase suffered a biphasic inactivation when exposed to NH2Cl. A rapid and irreversible phase of activity loss was followed by a much slower and reversible inactivation. Removal of tightly bound NADPH from the enzyme decreased the extent of the rapid phase; whereas addition of NADPH augmented it. The cat... | ['Ammonium Chloride', 'Animals', 'Aspergillus niger', 'Catalase', 'Cattle', 'Chloramines', 'Liver', 'NADP', 'Spectrophotometry', 'Taurine'] | 3,421,706 | [['D01.210.450.150.050', 'D01.625.062.249'], ['B01.050'], ['B01.300.381.081.450'], ['D08.811.682.732.332'], ['B01.050.150.900.649.313.500.380.271'], ['D01.210.150', 'D02.092.348'], ['A03.620'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['E05.196.712.726', 'E05.196.867... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Altered reward processing in women recovered from anorexia nervosa. | OBJECTIVE: Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life. Building on previous findings of altered striatal dopamine binding in anorexia nervosa, the authors sought to assess the response of the anterior ventral striatum ... | ['Adult', 'Anorexia Nervosa', 'Basal Ganglia', 'Body Mass Index', 'Body Weight', 'Brain Mapping', 'Caudate Nucleus', 'Discrimination, Psychological', 'Evoked Potentials', 'Feedback', 'Female', 'Functional Laterality', 'Gambling', 'Games, Experimental', 'Hemodynamics', 'Humans', 'Image Processing, Computer-Assisted', 'M... | 18,056,239 | [['M01.060.116'], ['F03.400.125'], ['A08.186.211.200.885.287.249'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E01.370.350.578.875.500', 'E01.370.376.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Mortality and incidence of cancer in a cohort of Swedish chimney sweeps: an extended follow up study. | Despite 200 years of efforts to regulate safety in this occupation, chimney sweeps have increased mortality from cancer, ischaemic heart disease, and respiratory disease. Mortality and incidence of cancer were examined in a cohort of 5542 Swedish chimney sweeps employed through their national trade union at any time be... | ['Adolescent', 'Adult', 'Aged', 'Cause of Death', 'Child', 'Cohort Studies', 'Follow-Up Studies', 'Humans', 'Incidence', 'Industry', 'Male', 'Middle Aged', 'Neoplasms', 'Occupational Diseases', 'Occupational Exposure', 'Sweden', 'Time Factors'] | 8,507,598 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
FOXP2: novel exons, splice variants, and CAG repeat length stability. | FOXP2 is a transcription factor containing a polyglutamine tract, a zinc-finger motif, and a forkhead DNA-binding domain. The FOXP2 gene is located on 7q31. A missense mutation in the forkhead domain (exon 14) and a balanced reciprocal translocation t(5;7)(q22;q31.2) with a breakpoint between exons 3b and 4 have recent... | ['Alternative Splicing', 'Brain Chemistry', 'DNA Primers', 'Exons', 'Forkhead Transcription Factors', 'Genetic Variation', 'Humans', 'Introns', 'Molecular Sequence Data', 'Movement Disorders', 'Mutation', 'Peptide Fragments', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reactio... | 12,189,486 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.150', 'G03.185'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.024.340.137.232'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Enzymatic hydrolysis of agar: purification and characterization of beta-neoagarotetraose hydrolase from Pseudomonas atlantica. | Agarose is degraded by a beta-agarase from Pseudomonas atlantica to neoagarooligosaccharides of degree of polymerization (DP), 4, 6, 8, and 10. A beta-neoagarotetraose hydrolase cleaves the central beta-linkage in neoagarotetraose and the beta-linkage near the nonreducing end in neoagarohexaose and -octaose to yield ne... | ['Agar', 'Cell Membrane', 'Diazonium Compounds', 'Enzyme Induction', 'Galactosidases', 'Hydrogen-Ion Concentration', 'Kinetics', 'Pseudomonas', 'Sodium Chloride'] | 17,463 | [['D09.698.360.041'], ['A11.284.149'], ['D02.172.383'], ['G05.308.320.200'], ['D08.811.277.450.410'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['B03.440.400.425.625.625', 'B03.660.250.580.590'], ['D01.210.450.150.875', 'D01.857.650']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multispectral Optoacoustic Tomography of Brown Adipose Tissue. | MSOT has revolutionized biomedical imaging because it allows anatomical, functional, and molecular imaging of deep tissues in vivo in an entirely noninvasive, label-free, and real-time manner. This imaging modality works by pulsing light onto tissue, triggering the production of acoustic waves, which can be collected a... | ['Adipose Tissue, Brown', 'Animals', 'Humans', 'Mice', 'Photoacoustic Techniques', 'Tomography'] | 29,896,652 | [['A10.165.114.322'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.565', 'E05.696'], ['E01.370.350.825']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chain cleavage and sulfoxidation of thiastearoyl-ACP upon reaction with stearoyl-ACP desaturase. | The fatty acid analogues 9- and 10-thiastearate were converted to acyl-ACP derivatives by in vitro enzymatic synthesis and reacted with the reconstituted soluble stearoyl-ACP Delta9 desaturase complex. Electrospray ionization mass spectral analysis of the acyl chains purified from the reaction mixtures showed that 10-t... | ['Acyl Carrier Protein', 'Plant Proteins', 'Spinacia oleracea'] | 12,820,892 | [['D12.776.157.050'], ['D12.776.765'], ['B01.650.940.800.575.912.250.200.800']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Control of transcription by nucleoid proteins. | Nucleoid proteins are a group of abundant DNA binding proteins that modulate the structure of the bacterial chromosome. They have been recruited as specific negative and positive regulators of gene transcription and their fluctuating patterns of expression are often exploited to impart an additional level of control wi... | ['Bacterial Proteins', 'DNA-Binding Proteins', 'Gene Expression Regulation, Bacterial', 'Repressor Proteins', 'Structure-Activity Relationship', 'Transcription, Genetic'] | 11,282,470 | [['D12.776.097'], ['D12.776.260'], ['G05.308.300'], ['D12.776.260.703', 'D12.776.930.780'], ['G02.111.830', 'G07.690.773.997'], ['G02.111.873', 'G05.297.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypoxemia associated with feeding in the preterm infant and full-term neonate. | Polygraphic monitoring studies were performed on more than 150 older preterm infants (postconceptional ages of 36 weeks or more) and full-term neonates to evaluate unexplained or persistent apnea. During polygraphic monitoring, 16 infants were observed to have hypoxemia associated with feedings. The feeding hypoxemia w... | ['Apnea', 'Bottle Feeding', 'Bradycardia', 'Carbon Dioxide', 'Female', 'Humans', 'Hypoxia', 'Infant', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Male', 'Monitoring, Physiologic', 'Respiratory Center', 'Retrospective Studies', 'Sleep, REM'] | 6,428,217 | [['C08.618.085', 'C23.888.852.130'], ['E02.421.150', 'F01.145.407.099', 'G07.203.650.220.500.250', 'G07.203.650.353.099'], ['C14.280.067.319', 'C23.550.073.300'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['M01.060.703'], ['M01.060.703.520']... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human macrophage-mediated cytotoxicity of Schistosoma mansoni. Functional and structural features of the effector cells. | Human monocytes were purified from peripheral blood and cultured in vitro on hydrophobic membranes. Such cells developed into mature tissue-type macrophages after approximately 1 week in culture. During this maturation period the macrophages developed a potent cytotoxic mechanism whereby they could kill the schistosomu... | ['Animals', 'Cell Survival', 'Humans', 'Macrophage Activation', 'Macrophages', 'Microscopy, Electron', 'Schistosoma mansoni'] | 2,630,567 | [['B01.050'], ['G04.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.287.500'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['E01.370.350.515.402', 'E05.595.402'], ['B01.050.500.500.736.715.770.680.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of Aryldifluoroamides by Copper-Catalyzed Cross-Coupling. | A copper-catalyzed coupling of aryl, heteroaryl, and vinyl iodides with á-silyldifluoroamides is reported. The reaction forms á,á-difluoro-á-aryl amides from electron-rich, electron-poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can ... | ['Amides', 'Catalysis', 'Copper', 'Fluorine'] | 26,929,068 | [['D02.065'], ['G02.130'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D01.268.380.300']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Free recall memory performance after aneurysmal subarachnoid hemorrhage. | Memory deficits for survivors of aneurysmal subarachnoid hemorrhage (SAH) are common, however, the nature of these deficits is not well understood. In this study, 24 patients with SAH and matched control participants were asked to study six lists containing words from four different categories. For half the lists, the ... | ['Adult', 'Aged', 'Attention', 'Case-Control Studies', 'Female', 'Humans', 'Male', 'Memory Disorders', 'Mental Recall', 'Middle Aged', 'Neuropsychological Tests', 'Subarachnoid Hemorrhage', 'Verbal Learning', 'Vocabulary'] | 22,325,677 | [['M01.060.116'], ['M01.060.116.100'], ['F02.830.104.214'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F01.700.625'], ['F02.463.425.540.641'], ['M01.060.116.630'], ['F04.711.513'], ['C10.228.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A qualitative study of exercise in older African American and white women in rural South Carolina: perceptions, barriers, and motivations. | Six focus groups were conducted with underactive African American (n = 16) and white (n = 23) women aged 50 years and older, residing in a nonmetropolitan county in South Carolina, to examine perceptions, barriers, and motivators related to exercise. Transcripts were coded and codes were entered into NUD*IST to assist ... | ['African Americans', 'Aged', 'Attitude to Health', 'European Continental Ancestry Group', 'Exercise', 'Female', 'Humans', 'Middle Aged', 'Motivation', 'Qualitative Research', 'Rural Population', 'South Carolina'] | 15,914,418 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['M01.686.508.400'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['H01.770.644.241.850'], ['N01.600.725'], ['Z01.107.567.875... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[Spontaneous intrahepatic hemorrhage: a severe complication of the Hellp syndrome. Value of early radiologic diagnosis. Apropos of a case]. | One case of spontaneous hepatic hemorrhage during a severe pre-eclampsia and Hellp syndrome (hemolysis, elevated liver function tests, low platelet count) is reported. This serious complication can be detected by ultrasonography and C.T. The normal sonographic appearance of the liver must prompt a new sonographic exami... | ['Adult', 'Anemia, Hemolytic', 'Female', 'Hemorrhage', 'Humans', 'Liver', 'Liver Diseases', 'Liver Function Tests', 'Platelet Count', 'Pregnancy', 'Pregnancy Complications', 'Syndrome', 'Thrombocytopenia', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 2,693,702 | [['M01.060.116'], ['C15.378.071.141'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C06.552'], ['E01.370.372.460'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01.370.225.625.625.625', 'E05.200.500.195.107.740', 'E05.200.625.107.700', 'E05.200.625.625.625', 'E05.242.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of shear bond strength of resin reinforced chemical cure glass ionomer, conventional chemical cure glass ionomer and chemical cure composite resin in direct bonding systems: an in vitro study. | The acid pretreatment and use of composite resins as the bonding medium has disadvantages like scratching and loss of surface enamel, decalcification, etc. To overcome disadvantages of composite resins, glass ionomers and its modifications are being used for bonding. The study was conducted to evaluate the efficiency o... | ['Acid Etching, Dental', 'Acrylic Resins', 'Aluminum Silicates', 'Composite Resins', 'Dental Bonding', 'Dental Materials', 'Dental Stress Analysis', 'Glass Ionomer Cements', 'Humans', 'Materials Testing', 'Orthodontic Brackets', 'Phosphoric Acids', 'Resin Cements', 'Self-Curing of Dental Resins', 'Shear Strength', 'Str... | 23,579,887 | [['E06.931.475.111'], ['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Femoral head stress fracture: an unknown complication following Sugioka's transtrochanteric rotational osteotomy. | Sugioka's transtrochanteric rotational osteotomy, as a treatment of osteonecrosis of the femoral head, has variable success rates. Its known complications include: progressive varus deformity, femoral neck fracture, and femoral head collapse. However, femoral head stress fracture has not been described as a complicatio... | ['Adult', 'Femoral Neck Fractures', 'Fractures, Stress', 'Humans', 'Male', 'Middle Aged', 'Osteonecrosis', 'Osteotomy', 'Radiography', 'Treatment Outcome'] | 21,410,119 | [['M01.060.116'], ['C26.404.061.425.500', 'C26.531.750.500', 'C26.558.276.425.500'], ['C26.404.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.116.852', 'C23.550.717.732'], ['E04.555.580'], ['E01.370.350.700'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Prevention of atherosclerosis and myocardial infarction in the liquidators of the accident at the Chernobyl Power Plant]. | The examination of 1450 patients-participants of elimination consequences after Chernobyl accident has revealed reasons of disablement: mental amd neurologic diseases -32%; cardiologic -28%; oncologic -13%; traumatic -14%. The reason of death in 60% were cardiologic diseases. Arteriosclerosis and myocardial infarction ... | ['Adult', 'Aged', 'Anticholesteremic Agents', 'Arteriosclerosis', 'Humans', 'Middle Aged', 'Myocardial Infarction', 'Power Plants', 'Pravastatin', 'Radioactive Hazard Release', 'Simvastatin', 'Ukraine'] | 10,366,958 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['C14.907.137.126'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['J01.780', 'J03.540.680'], ['D02.455.426.559.84... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Mutational analysis of phosphorylation sites in the Dictyostelium myosin II tail: disruption of myosin function by a single charge change. | The dynamic assembly/disassembly of non-muscle myosin II filaments is critical for the regulation of enzymatic activities and localization. Phosphorylation of three threonines, 1823, 1833 and 2029, in the tail of Dictyostelium discoideum myosin II has been implicated in control of myosin filament assembly. By systemati... | ['Animals', 'Cell Cycle', 'Dictyostelium', 'Mutagenesis, Site-Directed', 'Myosins', 'Phosphorylation'] | 10,682,841 | [['B01.050'], ['G04.144'], ['B01.046.550.200.300'], ['E05.393.420.601.575'], ['D05.750.078.730.475', 'D08.811.277.040.025.193.750', 'D12.776.210.500.600', 'D12.776.220.525.475'], ['G02.111.665', 'G02.607.780', 'G03.796']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype. | In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE levels). Angiotensin II levels are similar in both groups. | ['Adult', 'Angiotensin I', 'Angiotensin II', 'Antihypertensive Agents', 'Female', 'Gene Deletion', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Peptide Fragments', 'Peptidyl-Dipeptidase A', 'Vasoconstrictor Agents'] | 12,972,127 | [['M01.060.116'], ['D06.472.699.094.075', 'D12.644.400.070.075', 'D12.644.456.073.021', 'D12.644.548.058.075', 'D12.776.631.650.070.075', 'D23.469.050.050.025'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.954.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Time course of diaphragm function recovery after controlled mechanical ventilation in rats. | Controlled mechanical ventilation (CMV) is known to result in rapid and severe diaphragmatic dysfunction, but the recovery response of the diaphragm to normal function after CMV is unknown. Therefore, we examined the time course of diaphragm function recovery in an animal model of CMV. Healthy rats were submitted to CM... | ['Animals', 'Calpain', 'Carrier Proteins', 'Caspase 3', 'Diaphragm', 'Intracellular Signaling Peptides and Proteins', 'Male', 'Models, Animal', 'Muscle Contraction', 'Muscle Fibers, Skeletal', 'Muscle Proteins', 'Muscular Atrophy', 'Neutrophils', 'Oxidative Stress', 'Phosphoproteins', 'Proteolysis', 'Proto-Oncogene Pro... | 23,845,980 | [['B01.050'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['D12.776.157'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A02.633.567.900.300'], ['D12.644.360', 'D12.776.476'], ['E05.598'], ['G11.427.494... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of sex on comparative outcomes of bivalirudin versus unfractionated heparin in patients with acute coronary syndromes undergoing invasive management: a pre-specified analysis of the MATRIX trial. | AIMS: Our aim was to assess whether bivalirudin compared with unfractionated heparin (UFH) is associated with consistent outcomes in males and females with acute coronary syndrome (ACS) undergoing invasive management.METHODS AND RESULTS: In the MATRIX programme, 7,213 patients were randomised to bivalirudin or UFH. Pat... | ['Acute Coronary Syndrome', 'Anticoagulants', 'Antithrombins', 'Female', 'Heparin', 'Hirudins', 'Humans', 'Male', 'Peptide Fragments', 'Percutaneous Coronary Intervention', 'Recombinant Proteins', 'Treatment Outcome'] | 29,769,167 | [['C14.280.647.124', 'C14.907.585.124'], ['D27.505.954.502.119'], ['D27.505.519.389.745.800.449', 'D27.505.954.502.119.500'], ['D09.698.373.400'], ['D12.644.861.060.875', 'D12.776.872.060.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541'], ['E04.100.814.529.968', 'E04.502.382.968'], ['D12.776.828']... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Binding by immunoglobulin to the HPV-16-derived proteins L1 and E4 in cervical secretions of women with HPV-related cervical disease. | Although DNA of the human papillomaviruses (HPV) can be identified in epithelium of a large proportion of patients with genital squamous lesions, relatively little is known about the extent of the local host immune response to this virus. We analyzed cervical secretions from patients undergoing evaluation because of ab... | ['Antigen-Antibody Complex', 'Capsid Proteins', 'Cervix Uteri', 'Female', 'Genes, Viral', 'Humans', 'Immunoblotting', 'Immunoglobulins', 'Oncogene Proteins, Viral', 'Open Reading Frames', 'Papillomaviridae', 'Recombinant Fusion Proteins', 'Tumor Virus Infections', 'Uterine Cervical Neoplasms'] | 1,651,158 | [['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D12.776.964.970.600.550'], ['A05.360.319.679.256'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Retrospective motion gating in cardiac MRI using a simultaneously acquired navigator. | A simultaneous acquisition technique of image and navigator signals (simultaneously acquired navigator, SIMNAV) is proposed for cardiac magnetic resonance imaging (CMRI) in Cartesian coordinates. To simultaneously acquire both image and navigator signals, a conventional balanced steady-state free precession (bSSFP) pul... | ['Adult', 'Electrocardiography', 'Humans', 'Image Interpretation, Computer-Assisted', 'Magnetic Resonance Imaging, Cine', 'Male', 'Motion', 'Phantoms, Imaging', 'Respiration', 'Signal Processing, Computer-Assisted'] | 29,266,452 | [['M01.060.116'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.825.500.510'], ['G01.482'], ['E07.671'], ['G09.772.705'], ['L01.224.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Retinal vascular microfolds in highly myopic eyes. | PURPOSE: Retinal microfolds attributable to retinal vessels were first observed after vitrectomy for myopic foveoschisis and were believed to indicate inward retinal traction, possibly leading to high myopia-specific retinal diseases. We report retinal microfolds in high myopia without vitrectomy.DESIGN: Observational ... | ['Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myopia', 'Ophthalmoscopy', 'Retinal Diseases', 'Retinal Vessels', 'Tomography, Optical Coherence'] | 15,808,161 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C11.744.636'], ['E01.370.380.560'], ['C11.768'], ['A07.015.611'], ['E01.370.350.589.249.500', 'E01.370.350.825.805.500', 'E05.642.249.500']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A randomised, placebo-controlled 24-week study evaluating adjunctive brexpiprazole in patients with major depressive disorder. | OBJECTIVE: To evaluate brexpiprazole adjunctive to antidepressant therapies (ADTs) as maintenance treatment in patients with major depressive disorder with inadequate response to ADT, utilising a novel study design.METHODS: The study comprised an 8-week prospective treatment period with open-label ADT with double-blind... | ['Adolescent', 'Adult', 'Aged', 'Antidepressive Agents', 'Depressive Disorder, Major', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Quinolones', 'Serotonin Agents', 'Thiophenes', 'Young Adult'] | 30,223,911 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.427.700.122'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Therapeutic effects of different doses of polyethylene glycosylated porcine glucagon-like peptide-2 on ulcerative colitis in male rats. | BACKGROUND: Polyethylene glycosylated (PEGylated) porcine glucagon-like peptide-2 (pGLP-2) considerably increases half-life and stability compared with the native pGLP-2, but the effective dose for intestinal damage is still unclear. This study aims to evaluate the available dose of polyethylene glycosylated porcine gl... | ['Animals', 'Body Weight', 'Claudin-1', 'Colitis, Ulcerative', 'Colon', 'Cytokines', 'Dextran Sulfate', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Duodenum', 'Glucagon-Like Peptide 2', 'Intestinal Mucosa', 'Male', 'Polyethylene Glycols', 'Rats', 'Zonula Occludens-1 Protein'] | 28,259,136 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D12.776.543.940.200.100'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D12.644.276.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
An Abandoned Copper Mining Site in Cyprus and Assessment of Metal Concentrations in Plants and Soil. | Mining is an important source of metal pollution in the environment and abandoned mines are extremely restricted habitats for plants. Some plant species growing on metalliferous soils around mine tailings and spoil-heaps are metal-tolerant and accumulate high concentrations of metals. In this investigation, we aimed to... | ['Biodegradation, Environmental', 'Cyprus', 'Magnoliopsida', 'Metals, Heavy', 'Soil Pollutants', 'Tracheophyta'] | 25,976,876 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['Z01.542.580.500.300', 'Z01.639.640.300'], ['B01.650.940.800.575.912.250'], ['D01.268.556', 'D01.552.544'], ['D27.888.284.756'], ['B01.650.940.800.575.912']] | ['Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Effects of anti-guinea-pig beta 2-microgloblin antibodies on lymphocyte transformation induced by specific antigens or mitogens. | The effects of a goat anti-guinea-pig beta 2-microglobulin antiserum (a beta 2m) on lymphocyte transformation, induced by specific antigens or mitogens, were studied. a beta 2m was found to exert inhibitory effects on antigen stimulation, with three different antigens (purified protein devivative, hen egg-white lysozym... | ['Animals', 'Antigens', 'B-Lymphocytes', 'Beta-Globulins', 'Cells, Cultured', 'Concanavalin A', 'DNA', 'Goats', 'Guinea Pigs', 'Immune Sera', 'Lymph Nodes', 'Lymphocyte Activation', 'Phytohemagglutinins', 'Pokeweed Mitogens', 'Spleen', 'T-Lymphocytes', 'beta 2-Microglobulin'] | 86,202 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comparison of valsartan and captopril in patients with essential hypertension in Indonesia. | Adult Indonesian outpatients were randomised to receive either valsartan 80 mg once daily or captopril 25 mg twice daily for 8 weeks. The main criterion for tolerability was the incidence of adverse events. The primary efficacy variable was the change in mean sitting diastolic blood pressure (SDBP) from baseline to end... | ['Adult', 'Aged', 'Antihypertensive Agents', 'Captopril', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Tetrazoles', 'Treatment Outcome', 'Valine', 'Valsartan'] | 10,563,070 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['D12.125.072.401.623.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D03.383.129.617'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['D12.125.070.950', 'D12.125.142.930'], ['D03.383.12... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of alpha-interferon, 17 beta-estradiol, and tamoxifen on estrogen receptor concentration and cell cycle kinetics of MCF 7 cells. | The interaction of alpha-interferon, 17 beta-estradiol, and tamoxifen on estrogen receptor content, growth fraction, proliferative rate, and total protein synthesis of MCF 7 cells was investigated under culture conditions (minus phenol red and at low concentrations of "stripped" fetal calf serum) allowing for direct st... | ['Breast Neoplasms', 'Cell Cycle', 'Cell Division', 'Estradiol', 'Female', 'Humans', 'Interferon Type I', 'Kinetics', 'Receptors, Estrogen', 'Recombinant Proteins', 'Tamoxifen', 'Tumor Cells, Cultured'] | 2,386,944 | [['C04.588.180', 'C17.800.090.500'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['G01.374.66... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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