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A low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor priming regimen versus a daunorubicin plus cytarabine regimen as induction therapy for older patients with acute myeloid leukemia: A propensity score analysis. | This retrospective analysis compared the efficacy of intensive induction therapy consisting of daunorubicin and cytarabine (DNR-AraC) to that of less-intensive therapy including low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor priming (CAG). Patients aged 60 years or older who were newly diagn... | ['Aclarubicin', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Cytarabine', 'Daunorubicin', 'Female', 'Granulocyte Colony-Stimulating Factor', 'Humans', 'Induction Chemotherapy', 'Kaplan-Meier Estimate', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Propensity Score', 'Proportiona... | 26,790,727 | [['D02.455.426.559.847.562.050.050', 'D04.615.562.050.050', 'D09.408.051.059.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Neopterin plasma levels in burn patients. | Burn victims have severely depressed cellular immunity and despite careful hygiene, antibiotics and early surgical therapy the infection rate remains high. The assessment of plasma neopterin levels can be considered as an indirect measurement of macrophage function, because activation of macrophages is accompanied by t... | ['Adult', 'Bacteremia', 'Biopterin', 'Burns', 'Female', 'Humans', 'Immunity, Cellular', 'Macrophages', 'Male', 'Middle Aged', 'Neopterin', 'Prognosis'] | 1,642,764 | [['M01.060.116'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['D03.633.100.733.631.202', 'D08.211.090'], ['C26.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['M01.060.116.630'], ['D03.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of peroxynitrite on pulmonary edema and the oxidative state. | Excess nitric oxide (NO) generation in the presence of superoxide anion (O2-) leads to the formation of peroxynitrite which may result in lung injury. Oxidant-mediated lung injury has a critical role in pulmonary diseases. We therefore determined whether peroxynitrite causes lung fluid accumulation, lipid peroxidation,... | ['Animals', 'Blotting, Western', 'Bronchoalveolar Lavage Fluid', 'Dose-Response Relationship, Drug', 'Extravascular Lung Water', 'Lipid Peroxidation', 'Lung', 'Male', 'Nitrates', 'Organ Size', 'Perfusion', 'Pulmonary Edema', 'Rats', 'Rats, Sprague-Dawley', 'Thiobarbituric Acid Reactive Substances', 'Tyrosine'] | 10,914,333 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.927.100.500'], ['G07.690.773.875', 'G07.690.936.500'], ['A12.207.270.300'], ['G02.111.515', 'G03.295.531.587'], ['A04.411'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['E01.370.600.115.1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stress changes the representational landscape: evidence from word segmentation. | Over the past couple of decades, research has established that infants are sensitive to the predominant stress pattern of their native language. However, the degree to which the stress pattern shapes infants' language development has yet to be fully determined. Whether stress is merely a cue to help organize the patter... | ['Female', 'Humans', 'Infant', 'Male', 'Speech Production Measurement', 'Stress, Psychological', 'Vocabulary'] | 15,996,560 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.760'], ['F01.145.126.990', 'F02.830.900'], ['L01.559.598.901']] | ['Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Identification of chaperonin particles in mammalian brain cytosol and of T-complex polypeptide 1 as one of their components. | An approximately 950-kDa heteromeric particle was purified from guinea-pig and rat brain by sucrose gradient fractionation of post-mitochondrial supernatants. Further purification, by affinity chromatography on ATP-Sepharose and anion exchange FPLC on MonoQ, yielded a particle with typical chaperonin ultrastructure. On... | ['Animals', 'Antibodies, Monoclonal', 'Brain', 'Brain Chemistry', 'Centrifugation, Density Gradient', 'Chaperonin Containing TCP-1', 'Chaperonins', 'Chromatography, Affinity', 'Chromatography, Ion Exchange', 'Cytosol', 'Electrophoresis, Gel, Two-Dimensional', 'Electrophoresis, Polyacrylamide Gel', 'Guinea Pigs', 'Macro... | 8,098,357 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['E05.181.724.336', 'E05.196.941.336'], ['D08.811.277.040.025.142.750.500', 'D12.776.580.216.210.795.500'], ['D08.811.277.040.025.142', 'D12.776.580.216.210'], ['E05.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-inflicted hand injuries: diagnostic challenge and treatment. | Self-inflicted injuries are probably more common than is generally appreciated. Three patients with self-inflicted hand injuries are described. A delay in making the correct diagnosis resulted in severe hand disability in 2 of the patients. Early diagnosis of this entity, combined with prompt psychotherapy, prevented d... | ['Adolescent', 'Adult', 'Factitious Disorders', 'Female', 'Hand Injuries', 'Humans', 'Infections', 'Male', 'Self Mutilation', 'Skin Ulcer'] | 3,364,919 | [['M01.060.057'], ['M01.060.116'], ['F03.875.375'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['C26.780', 'F01.145.126.980.750'], ['C17.800.893']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis. | It is unclear whether the use of moxifloxacin (MFX), a newer synthetic fluoroquinolone, results in better outcomes in patients with ofloxacin (OFX)-resistant multidrug-resistant tuberculosis (MDR-TB). During the period from April 2006 to December 2013, a total of 2,511 patients with culture-confirmed tuberculosis (TB) ... | ['Aged', 'Antitubercular Agents', 'DNA Gyrase', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Fluoroquinolones', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Moxifloxacin', 'Mutation', 'Mycobacterium tuberculosis', 'Ofloxacin', 'Taiwan', 'Treatment Outcome', 'Tuberculosis, Multidrug-Resistant'] | 27,216,062 | [['M01.060.116.100'], ['D27.505.954.122.085.255'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['D03.633.100.810.835.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Neighborhood-level stroke hot spots within major United States cities. | OBJECTIVE: Identifying communities at high risk of stroke is an important step in improving systems of stroke care. Stroke is known to show spatial clustering at the state and county levels, but it is not known if clusters are present within city boundaries.METHODS: We performed a geospatial analysis of the prevalence ... | ['Cities', 'Cohort Studies', 'Cross-Sectional Studies', 'Geographic Mapping', 'Humans', 'Monte Carlo Method', 'Prevalence', 'Residence Characteristics', 'Retrospective Studies', 'Risk Factors', 'Socioeconomic Factors', 'Stroke', 'United States'] | 31,272,755 | [['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.389', 'E05.318.740.933.249', 'N05.715.360.750.746.249', 'N06.850.520.830.933.249'], ['B01.050.150.900.64... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Hydrogen bonding to the cysteine ligand of superoxide reductase: acid-base control of the reaction intermediates. | Superoxide reductase (SOR) is a non-heme iron metalloenzyme that detoxifies superoxide radical in microorganisms. Its active site consists of an unusual non-heme Fe(2+) center in a [His4Cys1] square pyramidal pentacoordination, with the axial cysteine ligand proposed to be an essential feature in catalysis. Two NH pept... | ['Catalytic Domain', 'Cysteine', 'Hydrogen Bonding', 'Hydrogen-Ion Concentration', 'Ligands', 'Models, Molecular', 'Mutagenesis, Site-Directed', 'Mutation', 'Oxidation-Reduction', 'Oxidoreductases', 'Proteobacteria', 'Quantum Theory'] | 23,917,995 | [['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G02.282'], ['G02.300'], ['D27.720.470.480'], ['E05.599.595'], ['E05.393.420.601.575'], ['G05.365.590'], ['G02.700', 'G03.295.531'], ['D08.811.682'], ['B03.660'], ['H01.671.579.800... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Validation of an analytical method for the determination of carbadox and olaquindox in feedstuff by liquid chromatography coupled to UV and/or diode array detection. | The performance characteristics of an analytical method based on high-performance liquid chromatography (HPLC) for the detection of the banned growth promoters, carbadox and olaquindox, in feedstuff were determined via a collaborative study. The relative standard deviation of repeatability (RSDr) ranged 1.1-5.5% for ca... | ['Animal Feed', 'Animals', 'Animals, Domestic', 'Carbadox', 'Chromatography, High Pressure Liquid', 'Drug and Narcotic Control', 'Food Analysis', 'Food Contamination', 'Growth Substances', 'Quinoxalines', 'Reproducibility of Results', 'Spectrophotometry, Ultraviolet'] | 17,852,387 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['B01.050.050.116'], ['D02.241.081.251.140', 'D03.633.100.857.140'], ['E05.196.181.400.300'], ['I01.880.604.605.250', 'N03.706.615.402.250', 'N04.452.706.310'], ['E05.362', 'J01.576.423.850.100'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.5... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Short communication: intermediate prevalence of HIV type 1 primary antiretroviral resistance in Cear? State, Northeast Brazil. | Brazil is a large developing country where almost all FDA-licensed antiretrovirals are made available to more than 200,000 individuals under antiretroviral treatment. General primary HIV-1 resistance in Brazil is assumed to be low, but data are scarce, especially in the Northeast region. To evaluate the prevalence of p... | ['Adolescent', 'Adult', 'Brazil', 'Cross-Sectional Studies', 'Drug Resistance, Viral', 'HIV-1', 'Homosexuality, Male', 'Humans', 'Male', 'Mutation', 'Polymerase Chain Reaction', 'Prospective Studies'] | 20,929,346 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.820.650.589.650.350.400'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A comparison of MMPI profiles for state and private disability insurance applicants. | The use of the MMPI in predicting successful rehabilitation outcomes has met with limited success. Because the motives of a disability insurance applicant may differ greatly from a disability insurance recipient, disability applicants were investigated. The MMPI scores of state disability applicants and private industr... | ['Adult', 'Disabled Persons', 'Female', 'Humans', 'Insurance Benefits', 'MMPI', 'Male', 'Motivation', 'Personality Disorders', 'Prognosis', 'Rehabilitation, Vocational', 'Sick Role', 'Social Security', "Workers' Compensation"] | 6,233,415 | [['M01.060.116'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.130'], ['F04.711.647.513.607'], ['F01.658', 'F01.752.543.500.750'], ['F03.675'], ['E01.789'], ['E02.760.169.063.500.782', 'E02.831.782', 'N02.421.784.644'], ['F01.829.316.616.751'], ['N03.219.521.346.506.849', 'N03.219.521... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Extended Pleurectomy and Decortication for Malignant Pleural Mesothelioma Is an Effective and Safe Cytoreductive Surgery in the Elderly. | BACKGROUND: A survival advantage has been observed among patients with malignant pleural mesothelioma undergoing maximal cytoreductive surgery and adjuvant therapy. Elderly patients are considered higher risk for these radical operations and are commonly not offered surgical treatment. We reviewed our experience with e... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cytoreduction Surgical Procedures', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Mesothelioma', 'Mesothelioma, Malignant', 'Middle Aged', 'Pleura', 'Pleural Neoplasms', 'Retrospective Studies', 'Survival Rate', 'Thoracic Surgical Procedures', 'Treatment Outcome'] | 26,319,490 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.166'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['C04.557.470.035.510.757', 'C04.557.470.660.510.757', 'C04.588.894.797.520.173', 'C04.588.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Apoptosis and its pathway in early post-implantation embryos of diabetic rats. | It has been reported that diabetes-induced inappropriate apoptosis in embryos during neurulation may be one of the mechanisms leading to neural tube defects. We studied apoptosis and the apoptotic pathway occurring in early post-implantation period embryos of non-diabetic and streptozotocin (STZ)-induced diabetic rats.... | ['Animals', 'Apoptosis', 'Caspase 3', 'Caspases', 'Cytochromes c', 'Diabetes Mellitus, Experimental', 'Embryo, Mammalian', 'Embryonic Development', 'Female', 'Genes, bcl-2', 'Immunohistochemistry', 'In Situ Nick-End Labeling', 'Pregnancy', 'Pregnancy in Diabetics', 'Proto-Oncogene Proteins c-bcl-2', 'RNA, Messenger', '... | 15,649,569 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['D08.244.286.100', 'D12.776.422.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Two-step biohydrometallurgical technology of copper-zinc concentrate processing as an opportunity to reduce negative impacts on the environment. | Polymetallic concentrates obtained during ore beneficiation pose a significant problem for the mining and metallurgy industry due to an increase in load on subsequent comminution steps and a high loss of metals in slag during smelting. Storage of such slag can lead to pollution of groundwater due to weathering. Biohydr... | ['Acidithiobacillus', 'Archaea', 'Copper', 'Iron', 'Metallurgy', 'Oxidation-Reduction', 'Zinc'] | 30,121,463 | [['B03.440.400.425.103', 'B03.660.250.015'], ['B02'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['J01.576.655.875.400'], ['G02.700', 'G03.295.531'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Stomahesive as a tracheostomy dressing. | Seven patients had occlusive stomahesive dressings placed on their tracheostomies. These patients were compared with four patients managed with standard tracheostomy care. Stomahesive was applied using a defined technique and all seven patients were followed until tracheostomy closure. The average duration of stomahesi... | ['Humans', 'Occlusive Dressings', 'Tissue Adhesives', 'Tracheotomy'] | 6,302,798 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.101.650'], ['D25.919', 'D27.720.102.919', 'E07.858.690.860', 'J01.637.051.919'], ['E04.580.907', 'E04.928.790']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The prognostic value of dobutamine stress echocardiography. A long-term follow-up study]. | BACKGROUND AND OBJECTIVE: The prognostic value of dobutamine stress echocardiography in patients with suspected or known coronary heart disease has not exactly been assessed. Purpose of the study was the assessment of the prognostic value of DSE regarding cardiac events, especially in patients with a normal DSE finding... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Cardiotonic Agents', 'Coronary Disease', 'Disease-Free Survival', 'Dobutamine', 'Echocardiography', 'Exercise Test', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Prognosis', 'Prospective Studies', 'Retrospective S... | 10,341,750 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.411.222', 'D27.720.799.080'], ['C14.280.647.250', 'C14.907.585.250'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase. | Lymphocyte polyclonal activation is a generalized mechanism of immune evasion among pathogens. In a mouse model of Trypanosoma cruzi infection (American trypanosomiasis), reduced levels of polyclonal lymphocyte responses correlate with resistance to infection and cardiopathy. We report here the characterization of a pa... | ['Amino Acid Isomerases', 'Amino Acid Sequence', 'Animals', 'B-Lymphocytes', 'Base Sequence', 'Cloning, Molecular', 'DNA Primers', 'Genes, Protozoan', 'In Vitro Techniques', 'Lymphocyte Activation', 'Mice', 'Mitogens', 'Molecular Sequence Data', 'Molecular Weight', 'Sequence Homology, Amino Acid', 'Trypanosoma cruzi'] | 10,932,226 | [['D08.811.399.894.200'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Differentiating malingering balance disorder patients from healthy controls, compensated unilateral vestibular loss, and whiplash patients using stance and gait posturography. | Differentiating balance disorder patients who are malingering from those with organic balance disorders is difficult and costly. We used trunk sway measured during several stance and gait tasks in 18 patients suspected of malingering in order to differentiate these from 20 patients who had suffered unilateral vestibula... | ['Adult', 'Diagnosis, Differential', 'Disability Evaluation', 'Electronystagmography', 'Expert Testimony', 'Female', 'Gait Disorders, Neurologic', 'Humans', 'Male', 'Malingering', 'Middle Aged', 'Postural Balance', 'Reference Values', 'Saccades', 'Skull Fractures', 'Vertigo', 'Vestibular Diseases', 'Vestibular Function... | 19,923,814 | [['M01.060.116'], ['E01.171'], ['E01.370.400'], ['E01.370.380.230.280', 'E01.370.382.900.280', 'E01.370.405.245.787.280', 'E01.370.405.260'], ['I01.880.604.583.232', 'N03.706.535.253'], ['C10.597.404', 'C23.888.592.413'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.126.925'], ['M01.060.116.630'], ['F02.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model†. | Advanced age is a risk factor undermining women's fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, we hypothesize that supplementation of embryo culture medium with extracellular vesicles from endome... | ['Animals', 'Cells, Cultured', 'Cellular Senescence', 'Coculture Techniques', 'Embryo Culture Techniques', 'Embryo, Mammalian', 'Endometrium', 'Extracellular Vesicles', 'Female', 'Fertilization in Vitro', 'Humans', 'Male', 'Maternal Age', 'Mesenchymal Stem Cells', 'Mice', 'Mice, Inbred C57BL', 'Oocyte Retrieval', 'Oocy... | 30,596,891 | [['B01.050'], ['A11.251'], ['G04.043'], ['E05.481.500.374'], ['E05.481.500.468'], ['A16.254'], ['A05.360.319.679.490'], ['A11.284.295.588'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.560', 'N05.715.350.075.550', 'N06.850.490.250.550'], ['A11.329.830.500', 'A11.87... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas. | BACKGROUND: Recently, more and more studies have demonstrated the pivotal role of programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway in the immune evasion of tumors from the host immune system. However, the role of PD-1/PD-L1 pathway in gastric neuroendocrine carcinomas (G-NECs) remains unknown.AIM: To i... | ['Aged', 'Antineoplastic Agents, Immunological', 'B7-H1 Antigen', 'Carcinoma, Neuroendocrine', 'DNA Copy Number Variations', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immunotherapy', 'Kaplan-Meier Estimate', 'Lymphocytes, Tumor-Infiltrating', 'Male', 'Middle Aged', 'Programmed Cell Death 1 Receptor... | 31,011,254 | [['M01.060.116.100'], ['D27.505.954.248.384'], ['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['C04.557.465.625.650.240', 'C04.557.470.200.025.370', 'C04.557.580.625.650.240'], ['G05.365.795.297.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differences between blood and liver aromatic DNA adduct formation. | Aromatic DNA adducts in the livers and blood of grey mullet (Mugil sp.) have been monitored between 1993 and 1996 by the isolation of DNA and the postlabeling of the DNA adducts with 32P. The grey mullet were sampled from three well-characterised harbours, two in the northeastern Mediterranean and one in the northeaste... | ['Animals', 'Carcinogens', 'DNA Adducts', 'Environmental Monitoring', 'Fishes', 'Liver', 'Phosphorus Radioisotopes', 'Polycyclic Aromatic Hydrocarbons', 'Seawater', 'Water Pollutants, Chemical'] | 11,341,698 | [['B01.050'], ['D27.888.569.100'], ['D13.444.308.135', 'G05.200.104'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.493'], ['A03.620'], ['D01.268.666.500.604', 'D01.496.669.604', 'D01.496.749.658'], ['D02.455.426.559.847', 'D04.615'], ['G16.500.275.725.500'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. | The decapeptide sequence of GnRH-II is conserved in all jawed vertebrate species studied to date. New data for cattle (Bos taurus) indicates a gene encoding GnRH-II decapeptide possessing arginine (codon: CGG) rather than tryptophan (TGG) at position three in the mature peptide. This substitution is unique. We confirme... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'COS Cells', 'Cattle', 'Chlorocebus aethiops', 'Codon, Terminator', 'Gonadotropin-Releasing Hormone', 'Humans', 'Inositol Phosphates', 'Molecular Sequence Data', 'Mutation', 'Protein Precursors', 'Receptors, LHRH', 'Sheep'] | 16,916,952 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.500.380.271'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D13.444.735.544.355.250', 'G05.360.335.355.250', 'G05.360.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore to the 5' end of DNA. | Three single-stranded DNA molecules of different lengths were synthesized and characterized, each containing a fluorescent dye (6-carboxyfluorescein) connected to the 5' end via a photocleavable 2-nitrobenzyl linker and a biotin moiety at the 3' end. UV irradiation (lambda approximately 340 nm) of solutions containing ... | ['Biotin', 'Chromatography, High Pressure Liquid', 'Fluorescent Dyes', 'Oligonucleotides', 'Photolysis', 'Sequence Analysis, DNA', 'Ultraviolet Rays'] | 12,515,854 | [['D03.383.129.308.080', 'D08.211.096'], ['E05.196.181.400.300'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D13.695.578.424'], ['G02.740.685'], ['E05.393.760.700'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600', 'G16... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Successful immunotherapy in a murine metastasizing fibrosarcoma model. | Antigenic differences were demonstrated between the primary murine fibrosarcoma and its metastases. Immunization with irradiated primary tumor cells (TC) protected C57B1/6J mice against subsequent challenge with those cells, but not against challenge with cells from pulmonary metastases (PMC). Mice immunized with irrad... | ['Animals', 'Antigens, Neoplasm', 'Cell Line', 'Cells, Cultured', 'Cyclophosphamide', 'Disease Models, Animal', 'Fibrosarcoma', 'Immunotherapy', 'Liver Neoplasms', 'Lung Neoplasms', 'Mice', 'Mice, Inbred C57BL'] | 6,717,025 | [['B01.050'], ['D23.050.285'], ['A11.251.210'], ['A11.251'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C04.557.450.565.590.350', 'C04.557.450.795.350'], ['E02.095.465.425'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['C04.588.894.797.520', 'C08.381... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment failure with 2 g of azithromycin (extended-release formulation) in gonorrhoea in Japan caused by the international multidrug-resistant ST1407 strain of Neisseria gonorrhoeae. | OBJECTIVES: Antimicrobial resistance in Neisseria gonorrhoeae is a major public health concern globally. We report the first verified treatment failure of gonorrhoea with 2 g of azithromycin (extended-release formulation) in Japan and characteristics of the corresponding N. gonorrhoeae isolates.METHODS: Pre- and post-t... | ['Adolescent', 'Anti-Bacterial Agents', 'Azithromycin', 'Bacterial Proteins', 'Bacterial Typing Techniques', 'Cefixime', 'Ceftriaxone', 'Ciprofloxacin', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Gonorrhea', 'Humans', 'Japan', 'Microbial Sensitivity Tests', 'Multilocus Sequence Typing', 'Neisseria gonorrhoeae',... | 24,777,907 | [['M01.060.057'], ['D27.505.954.122.085'], ['D02.540.576.500.992.050'], ['D12.776.097'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['D02.065.589.099.249.190.190.115', 'D02.886.665.074.190.190.115', 'D03.633.100.300.249.190.190.115'], ['D02.065.589.099.249.190.190.155', 'D02.886.665.074.190.190.155', 'D03.633.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Clinical outcome in 19 cats with clinical and magnetic resonance imaging diagnosis of ischaemic myelopathy (2000-2011). | Previous publications on ischaemic myelopathy in cats are limited to single case reports and small case series. The overall prognosis appears poor, with 42% of cats being euthanased. In this study the clinical outcome of 19 cats with a presumptive diagnosis of ischaemic myelopathy [based on clinical and magnetic resona... | ['Animals', 'Cat Diseases', 'Cats', 'Female', 'Magnetic Resonance Imaging', 'Male', 'Retrospective Studies', 'Spinal Cord Ischemia'] | 23,048,075 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.370.350.825.500'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['C10.228.854.785.650', 'C14.907.790.55... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In their own words: a model of healthy aging. | Many previous studies have assessed the aging process by measuring clinical and functional variables. To supplement that quantitative understanding, we asked older people what constitutes their health and contributes to it. Using grounded theory-type methods, we analyzed semi-structured interviews with 22 study subject... | ['Adaptation, Psychological', 'Aged', 'Aging', 'Attitude', 'Female', 'Health Services Research', 'Health Status', 'Humans', 'Life Style', 'Male', 'Models, Theoretical'] | 11,522,138 | [['F01.058'], ['M01.060.116.100'], ['G07.345.124'], ['F01.100'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['E05.599']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. | CONTEXT: Little is known regarding carotid intimal medial thickness (IMT) in HIV-infected women and the risk factors for subclinical atherosclerosis in this population, including antiretroviral therapy and the metabolic syndrome.OBJECTIVE: Our objective was to assess carotid IMT in relationship to HIV status and antire... | ['Adult', 'Anti-Retroviral Agents', 'Atherosclerosis', 'Biomarkers', 'Body Composition', 'Carotid Artery, Common', 'Case-Control Studies', 'Female', 'HIV Infections', 'Humans', 'Metabolic Syndrome', 'Middle Aged', 'Multivariate Analysis', 'Protease Inhibitors', 'Radiography', 'Risk Factors', 'Tunica Intima', 'Tunica Me... | 17,003,092 | [['M01.060.116'], ['D27.505.954.122.388.077'], ['C14.907.137.126.307'], ['D23.101'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['A07.015.114.186.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lipidomic Profiling of the Olive (Olea europaea | Olives (Olea europaea L.) are classic ingredients in the Mediterranean diet with well-known health benefits, but their lipid composition has not been fully addressed. In this work, we characterised triacylglycerol (TAG) and polar lipid profiles of the olive pulp while using a complementary methodological approach that ... | ['Chromatography, Liquid', 'Chromatography, Reverse-Phase', 'Fruit', 'Functional Food', 'Lipid Metabolism', 'Lipidomics', 'Lipids', 'Molecular Structure', 'Olea', 'Portugal', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry', 'Triglycerides'] | 31,337,054 | [['E05.196.181.400'], ['E05.196.181.400.495'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G07.203.300.572', 'J02.500.572'], ['G03.458'], ['H01.158.201.586.500', 'H01.158.273.180.599.500', 'H01.181.122.638.500'], ['D10'], ['G02.111.570', 'G02.466'], ['B01.650.940.800.575.912.250.583.640.666'], ['Z01.542.727'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
A simple and rapid method for the identification of cycling cells in freshly excised tumours. | Cytogenetic studies of fresh solid tumours are hampered by the small numbers of poor quality metaphases which are obtained through direct preparations. The proportion of cycling cells in freshly excised tumours have been identified by measuring the incorporation of the nucleoside analogue 5-bromo-2'deoxyuridine (BrUdR)... | ['Antibodies, Monoclonal', 'Bromodeoxyuridine', 'Carcinoma', 'Cell Cycle', 'Cells, Cultured', 'Culture Media', 'DNA', 'Female', 'Flow Cytometry', 'Humans', 'Immunoenzyme Techniques', 'Ovarian Neoplasms', 'Staining and Labeling', 'Time Factors'] | 2,416,515 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['C04.557.470.200'], ['G04.144'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['D13.444.308'], ['E01.370.225.500.363.342', 'E01.370.225.500.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Template specificity of DNA-dependent RNA polymerase I and II for synthetic polynucleotides during development of the cellular slime mold Dictyostelium discoideum. | The template specificity of DNA-dependent RNA polymerases I and II (ribonucleoside 5'-triphosphate : RNA nucleotidyltransferase [EC 2.7.7.6]) of Dictyostelium discoideum was investigated with several synthetic polynucleotides at three different stages of development. Both the enzymes exhibited several common characteri... | ['DNA-Directed RNA Polymerases', 'Dictyostelium', 'Polydeoxyribonucleotides', 'RNA Polymerase I', 'RNA Polymerase II', 'Structure-Activity Relationship', 'Substrate Specificity', 'Templates, Genetic'] | 7,390,995 | [['D08.811.913.696.445.735.270'], ['B01.046.550.200.300'], ['D13.695.578.500'], ['D08.811.913.696.445.735.270.750'], ['D08.811.913.696.445.735.270.762'], ['G02.111.830', 'G07.690.773.997'], ['G02.111.835'], ['G05.360.840']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Efficacy diacetylmorphine (pharmaceutical heroin) for heroin treatment ]. | Before implementing the TADAM project in Belgium (a heroin-assisted treatment trial), our research team studied the trials in other countries. Since 1994, six randomised controlled trials have been developed using the same treatment model of heroin-assisted treatment (HAT). Each trial concluded that HAT had more effica... | ['Heroin', 'Heroin Dependence', 'Humans', 'Narcotics', 'Opiate Substitution Treatment', 'Randomized Controlled Trials as Topic'] | 21,287,763 | [['D03.132.577.249.562.445', 'D03.605.497.607.490', 'D03.633.400.686.607.490', 'D04.615.723.795.576.445'], ['C25.775.643.500.400', 'F03.900.647.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.600', 'D27.505.696.663.850.014.760', 'D27.505.954.427.040.550', 'D27.505.954.427.210.600'], ['E02.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo. | Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and photochemical imaging of cultured glioma cells and experimental gliomas ex vivo. We demonstrated that high microanatomica... | ['Animals', 'Brain', 'Brain Neoplasms', 'Disease Models, Animal', 'Glioma', 'Mice', 'Mice, Inbred Strains', 'Microscopy, Fluorescence, Multiphoton', 'Sensitivity and Specificity'] | 17,325,340 | [['B01.050'], ['A08.186.211'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.99... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Maladapted Prey Subsidize Predators and Facilitate Range Expansion. | Dispersal of prey from predator-free patches frequently supplies a trophic subsidy to predators by providing more prey than are produced locally. Prey arriving from predator-free patches might also have evolved weaker defenses against predators and thus enhance trophic subsidies by providing easily captured prey. Using... | ['Adaptation, Biological', 'Animal Distribution', 'Animals', 'Biological Evolution', 'Climate Change', 'Computer Simulation', 'Gene Flow', 'Population Dynamics', 'Predatory Behavior'] | 31,490,731 | [['G16.012'], ['F01.145.113.069', 'G16.049'], ['B01.050'], ['G05.045', 'G16.075'], ['G16.500.175.374'], ['L01.224.160'], ['G05.330.159'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['F01.145.113.111.600', 'F01.145.113.252.520']] | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Protein expression changed by nicotine in rat vascular smooth muscle cells. | In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially expr... | ['Animals', 'Cells, Cultured', 'Electrophoresis, Gel, Two-Dimensional', 'Immunohistochemistry', 'Male', 'Mass Spectrometry', 'Muscle, Smooth, Vascular', 'Nicotine', 'Peptide Mapping', 'Proteins', 'Proteome', 'Proteomics', 'Rats', 'Rats, Wistar', 'Reproducibility of Results', 'Reverse Transcriptase Polymerase Chain Reac... | 17,933,390 | [['B01.050'], ['A11.251'], ['E05.196.401.250', 'E05.301.300.230'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E05.196.566'], ... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Human airway epithelial cells express interleukin-2 in vitro. | Human airway epithelial cells (AEC) produce the T cell growth factor interleukin (IL)-2 that likely modulates the T cell lung inflammatory response. IL-2 mRNA from cultured AEC and from Jurkat T cells was analyzed by reverse transcription-polymerase chain reaction and Northern hybridization. IL-2 mRNA is present consti... | ['Adult', 'Biological Assay', 'Bronchi', 'Cells, Cultured', 'Enzyme-Linked Immunosorbent Assay', 'Epithelial Cells', 'Epithelium', 'Female', 'Gene Expression Regulation', 'Humans', 'Interleukin-2', 'Male', 'Middle Aged', 'RNA, Messenger', 'T-Lymphocytes', 'Transcription, Genetic'] | 9,124,379 | [['M01.060.116'], ['E05.091'], ['A04.411.125'], ['A11.251'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.436'], ['A10.272'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Correlation between hemoglobin F levels and single nucleotide polymorphism at BCL11A gene rs11886868 locus in â-thalassemia patients]. | This study was aimed to analyze hemoglobin F (HbF) level and single nucleotide polymorphisms at rs11886868 locus of BCL11A gene in â-thalassemia patients, and to explore correlation between them. 89 mild â-thalassemia patients with known mutations were registered, and HbF levels were determined by capillary electrophor... | ['Adolescent', 'Adult', 'Carrier Proteins', 'Child', 'Female', 'Fetal Hemoglobin', 'Haplotypes', 'Humans', 'Male', 'Middle Aged', 'Nuclear Proteins', 'Polymorphism, Single Nucleotide', 'Repressor Proteins', 'Young Adult', 'beta-Thalassemia'] | 22,739,175 | [['M01.060.057'], ['M01.060.116'], ['D12.776.157'], ['M01.060.406'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.660'], ['G05.365.795.598'], ['D12.776.260.703', 'D12.776.930.780'], ['M01.060.116.815'], ['C15.378.071... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cardiac output determination. | Critical care nurses frequently are involved in obtaining cardiac output measurements and in using these data to assess and to plan therapy. This article reviews the physiologic determinants of cardiac output and the clinical factors that influence these determinants. Principles and techniques of common methods of card... | ['Cardiac Output', 'Critical Care', 'Humans', 'Monitoring, Physiologic', 'Nursing Assessment', 'Nursing Process'] | 8,452,746 | [['E01.370.370.380.150', 'G09.330.380.124'], ['E02.760.190', 'N02.421.585.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520'], ['N04.590.233.508.480'], ['N04.590.233.508']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation. | The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid. | ['Crystallization', 'Crystallography, X-Ray', 'Malates', 'Molecular Conformation', 'Stereoisomerism', 'Tartrates'] | 23,073,186 | [['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D02.241.081.337.463', 'D02.241.511.505'], ['G02.111.570.820'], ['G02.607.445.682'], ['D02.241.081.337.864', 'D02.241.081.844.759', 'D02.241.511.902.759', 'D09.811.779']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Methodology of the colorimetric determination of alkylating cytostatics with 4-(4'-nitrobenzyl)pyridine (NBP) in plasma]. | The sensitivity of the colorimetric determination of alkylating cytostatics with 4-(4'-nitrobenzyl)pyridine (NBP) has been increased by modifying procedures described in the literature. This increase in sensitivity was accomplished as follows: --Precipitation of protein with absolute ethanol at degree C; --reduction of... | ['Alkylating Agents', 'Antineoplastic Agents', 'Colorimetry', 'Electrodes', 'Humans', 'Indicators and Reagents', 'Proteins', 'Pyridines'] | 7,163,361 | [['D27.505.519.124', 'D27.888.569.035'], ['D27.505.954.248'], ['E05.196.922.250'], ['E07.305.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['D12.776'], ['D03.383.725']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Incorporation of 14-c-1-glycine into tissue proteins under the influence of insulin and its derivatives]. | Effect of parenterally injected insulin and its composite sulpho-A- and B-chains on the rate of protein synthesis by the organs of the rat was investigated. It has been shown that insulin accelerates the incorporation of I-C14-glycine into proteins of the liver, kidneys, pancreas, spleen, sceletal muscules, thyroid gla... | ['Adrenal Glands', 'Animals', 'Glycine', 'Insulin', 'Kidney', 'Liver', 'Male', 'Muscles', 'Organ Specificity', 'Pancreas', 'Protein Biosynthesis', 'Rats', 'Spleen', 'Thymus Gland', 'Thyroid Gland'] | 656,578 | [['A06.300.071'], ['B01.050'], ['D12.125.481'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A05.810.453'], ['A03.620'], ['A02.633', 'A10.690'], ['G07.650'], ['A03.734'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['B01.050.150.900.649.313.992.635.505.700'], ['A10.549.700', 'A15.382.520.604... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo confocal microscopy of long-standing mixed-form vernal keratoconjunctivitis. | PURPOSE: To report the morphological characteristics of long-term mixed-form vernal keratoconjunctivitis (VKC) using in vivo laser scanning confocal microscopy (LSCM).DESIGN: Descriptive case report.METHODS: In vivo LSCM was performed on a Chinese patient diagnosed as bilateral mixed-form VKC for 14 years. Central corn... | ['Adult', 'Asian Continental Ancestry Group', 'Chronic Disease', 'Conjunctiva', 'Conjunctivitis, Allergic', 'Dendritic Cells', 'Epithelium, Corneal', 'Fibrosis', 'Humans', 'Male', 'Microscopy, Confocal'] | 20,818,997 | [['M01.060.116'], ['M01.686.508.200'], ['C23.550.291.500'], ['A09.371.060.200', 'A09.371.337.168'], ['C11.187.183.200', 'C20.543.480.200'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['A09.371.060.217.325', 'A10.272.510'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E0... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Photodynamic damage by liposome-bound porphycenes: comparison between in vitro and in vivo models. | Photodynamic efficacy of four tetrakis (methoxyethyl) porphycene (TMPn) derivatives encapsulated in liposomes, was studied in vitro and in vivo. Fluorescence and absorption measurements were used to determine aggregation in dipalmitoyl phosphatidylcholine (DPPC) liposomes; no spectral changes were found when dissolving... | ['Absorption', 'Animals', 'Cell Line', 'Chorion', 'Dogs', 'Drug Carriers', 'Fluorescence', 'Liposomes', 'Molecular Structure', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins'] | 9,491,592 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['B01.050'], ['A11.251.210'], ['A10.615.284.473', 'A16.254.750.473'], ['B01.050.150.900.649.313.750.250.216.200'], ['D26.255.260', 'E02.319.300.380'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D25.479.517', 'D26.255.260.517', 'J01.637... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Immunoproliferative small-intestinal disease: clinical features and outcome in 30 cases. | Experience with 30 patients with immunoproliferative small intestinal disease followed prospectively between 1971 and 1986 is described. All presented with malabsorption or growth retardation and had similar clinical, biochemical, and radiological features, irrespective of the presence of lymphoma or immunological abno... | ['Adolescent', 'Adult', 'Anemia', 'Biopsy', 'Blood Proteins', 'Child', 'Female', 'Follow-Up Studies', 'Humans', 'Immunoglobulins', 'Immunoproliferative Small Intestinal Disease', 'Intestinal Neoplasms', 'Intestine, Small', 'Lymphoma', 'Male'] | 3,683,173 | [['M01.060.057'], ['M01.060.116'], ['C15.378.071'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.124'], ['M01.060.406'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
DNA-binding properties of gene-5 protein encoded by bacteriophage M 13. 1. The kinetics of the dissociation of gene-5-protein.polynucleotide complexes upon addition of salt. | The irreversible dissociation kinetics of complexes of M13-encoded gene-5 protein with the polynucleotides poly(dA) and M13 DNA was studied by means of stopped-flow experiments. A linear decay was found for all gene-5-protein.poly(dA) complexes and for the gene-5-protein.M13 DNA complexes for which the DNA lattice was ... | ['Binding, Competitive', 'DNA, Viral', 'DNA-Binding Proteins', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Mathematics', 'Poly A', 'Polydeoxyribonucleotides', 'Protein Binding', 'Salts', 'Viral Proteins'] | 3,262,510 | [['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D13.444.308.568'], ['D12.776.260'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['H01.548'], ['D13.695.578.550.500'], ['D13.695.578.500'], ['G02.111.679', 'G03.808'], ['D01.786'], ['D12.776.964']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A retrospective job exposure matrix for estimating exposure to 2,3,7, 8-tetrachlorodibenzo-p-dioxin. | BACKGROUND: A job exposure matrix was developed to estimate the 2,3, 7,8-tetrachlorodibenzo-p-dioxin exposure of 3,538 workers who produced 2,4,5-trichlorophenol and its derivatives.METHODS: Daily TCDD exposure scores that were plant, process, and period specific were estimated for each job title as the product of 1) t... | ['Algorithms', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Maximum Allowable Concentration', 'National Institute for Occupational Safety and Health, U.S.', 'Occupational Diseases', 'Occupational Exposure', 'Polychlorinated Dibenzodioxins', 'Retrospective Studies', 'Risk Assessment', 'United States'] | 10,861,764 | [['G17.035', 'L01.224.050'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.210', 'N06.850.460.350.600.615'], ['I01.409.418.750.600.650.200.520', 'N03.540.348.500.500.600.650.225.520'], ['C24'], ['N06.850.460.350.600'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Diagnosis of intrahepatic stones: superiority of MR cholangiopancreatography over endoscopic retrograde cholangiopancreatography. | OBJECTIVE: The purpose of this study was to compare the efficacy of MR cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) for the diagnosis of intrahepatic stones.MATERIALS AND METHODS: Of the 318 patients who underwent MRCP examinations at our institution during an 18-month perio... | ['Adult', 'Aged', 'Bile Duct Diseases', 'Bile Ducts', 'Bile Ducts, Intrahepatic', 'Cholangiopancreatography, Endoscopic Retrograde', 'Cholelithiasis', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Pancreas', 'Sensitivity and Specificity'] | 12,130,445 | [['M01.060.116'], ['M01.060.116.100'], ['C06.130.120'], ['A03.159.183'], ['A03.159.183.158', 'A03.620.150'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['C06.130.409'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of the optic nerve of the rat. | Development of the rat optic nerve is studied electron microscopically. By marked bionecrosis, many neuroepithelial cells of the fissure portion of the optic stalk are eliminated immediately following optic cup formation. A small number of the surviving neuroepithelial cells forms the tubular optic stalk. The wall cell... | ['Animals', 'Astrocytes', 'Axons', 'Cell Differentiation', 'Endoplasmic Reticulum', 'Female', 'Intercellular Junctions', 'Meninges', 'Mitosis', 'Myelin Sheath', 'Nerve Fibers, Myelinated', 'Oligodendroglia', 'Optic Nerve', 'Pigment Epithelium of Eye', 'Pregnancy', 'Rats'] | 1,184,307 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G04.152'], ['A11.284.430.214.190.875.248'], ['A11.284.149.165.420'], ['A08.186.566'], ['G04.144.220.220.781', 'G05.113.220.781'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.8... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study. | BACKGROUND: Cardiovascular drugs play a major role in the pre- and postoperative care in neonates with congenital heart disease. Management strategies aim to optimise contractility, improve diastolic function, maintain adequate preload, and reduce afterload. Levosimendan, a novel inodilator agent, enhances myocardial c... | ['Blood Pressure', 'Cardiac Output, Low', 'Cardiotonic Agents', 'Cerebrovascular Circulation', 'Heart Defects, Congenital', 'Heart Rate', 'Hemoglobins', 'Humans', 'Hydrazones', 'Infant, Newborn', 'Lactic Acid', 'Prospective Studies', 'Pyridazines', 'Respiration', 'Simendan', 'Statistics, Nonparametric'] | 20,881,438 | [['E01.370.600.875.249', 'G09.330.380.076'], ['C14.280.148', 'C23.888.192'], ['D27.505.954.411.222', 'D27.720.799.080'], ['G09.330.100.159'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Pre-operation evaluation and intra-operation management of cochlear implantation]. | OBJECTIVE: To summarize pre-operation evaluation experiences in cochlear implantation.METHODS: Performing auditory evaluation and image analysis seriously in 158 severe hearing loss or total deaf cases before cochlear implantation, comparing their performance with the findings during and post operation.RESULTS: Among t... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Cochlear Implantation', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Preoperative Period', 'Tomography, X-Ray Computed', 'Young Adult'] | 15,696,916 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['E04.580.450.220', 'E04.650.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E04.614.937', 'N02.421.585.753.937'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.81... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa. | To determine if the clearance of hepatitis C genotype 1 virus (HCV) is dependent on the dose of interferon alfa-2b (IFN-alpha2b), the acute clearance of HCV after a single dose of either 3, 5, or 10 mIU of IFN-alpha was compared in patients with chronic hepatitis C. HCV-RNA levels following IFN-alpha administration wer... | ['Adult', 'Antiviral Agents', 'Dose-Response Relationship, Drug', 'Female', 'Hepatitis C', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Male', 'Middle Aged', 'Recombinant Proteins', 'Time Factors', 'Viral Load'] | 9,214,474 | [['M01.060.116'], ['D27.505.954.122.388'], ['G07.690.773.875', 'G07.690.936.500'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250.500', 'D12.776.467.374.440.890.250.500', 'D23.529.374.440.890.250.500'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Unstirred water layers in rabbit intestine: effects of guar gum. | Guar gum has been shown to affect the absorption of several different nutrients in clinical studies; however, the mechanisms for decreased absorption have not been defined. A possibility not studied with regard to guar gum, but previously demonstrated to be important in absorption, is the effect of change in the unstir... | ['Animals', 'Body Water', 'Galactans', 'Intestinal Absorption', 'Intestine, Small', 'Jejunum', 'Male', 'Mannans', 'Plant Gums', 'Rabbits'] | 3,820,520 | [['B01.050'], ['A12.207.200'], ['D09.698.360'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['A03.556.124.684'], ['A03.556.124.684.500', 'A03.556.249.750'], ['D09.698.550'], ['D05.750.078.739', 'D09.698.700', 'D20.215.721.249'], ['B01.050.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parental employment at time of conception and risk of cancer in offspring. | Studies on the possible association between exposures of parents at the time off conception and cancer in their offspring have provided no clear answer. In this large, population-based, record-linkage study, 1747 childhood cancer cases were identified in the Danish Cancer Registry and matched with 8630 population contr... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Denmark', 'Female', 'Humans', 'Kidney Neoplasms', 'Male', 'Medical Record Linkage', 'Neoplasms', 'Occupational Exposure', 'Osteosarcoma', 'Parents', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Risk Factors'] | 1,832,903 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.542.816.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['E05.318.308.940.968.500', 'N04.452.859.564.550', 'N05.715.360.300.... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Immunohistochemical Detection of ROS1 Fusion. | Objectives: Patients whose tumors harbor ROS1 translocation may benefit from targeted therapy. Detection of ROS1 rearrangement can be done by three methods: immunohistochemistry, fluorescence in situ hybridization, and molecular assays. Immunohistochemistry would be a cost-effective means to screen for ROS1 translocati... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Female', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization, Fluorescence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Oncogene Proteins, Fusion', 'Protein-Tyrosine Kinases', 'Proto-Oncogene Proteins'] | 28,007,702 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Mutational analysis of p73 and p53 in human cancer cell lines. | p73 is a candidate tumor suppressor gene with substantial DNA and protein homology to the p53 tumor suppressor gene. We have investigated two hypotheses: (a) p73 is mutated in diverse types of human cancer, and (b) p73 is functionally redundant with p53 in carcinogenesis so that mutations would be exclusive in these tw... | ['DNA Mutational Analysis', 'DNA-Binding Proteins', 'Genes, Tumor Suppressor', 'Humans', 'Introns', 'Lung Neoplasms', 'Molecular Sequence Data', 'Mutation', 'Neoplasms', 'Nuclear Proteins', 'Polymerase Chain Reaction', 'Polymorphism, Single-Stranded Conformational', 'Sequence Analysis, DNA', 'Tumor Cells, Cultured', 'T... | 10,362,363 | [['E05.393.760.700.300'], ['D12.776.260'], ['G05.360.340.024.340.375.249', 'G05.360.340.024.340.415.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['L01.453.245.667'], ['G05.365.590'], ['C04'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Infrared laser ablation sampling coupled with data independent high resolution UPLC-IM-MS/MS for tissue analysis. | Infrared laser ablation microsampling was used with data-dependent acquisition (DDA) and ion mobility-enhanced data-independent acquisition (HDMSE) for mass spectrometry based bottom-up proteomics analysis of rat brain tissue. Results from HDMSE and DDA analyses of the 12 laser ablation sampled tissue sections showed t... | ['Animals', 'Brain Chemistry', 'Chromatography, High Pressure Liquid', 'Infrared Rays', 'Laser Therapy', 'Rats', 'Tandem Mass Spectrometry', 'Tissue Extracts'] | 30,193,623 | [['B01.050'], ['G02.111.150', 'G03.185'], ['E05.196.181.400.300'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230.300.100.725.525.400'], ['E02.594', 'E04.014.520'], ['B01.050.150.900.649.313.992.635.505.700'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Home-based multicomponent rehabilitation program for older persons after hip fracture: a randomized trial. | OBJECTIVE: To determine whether a home-based systematic multicomponent rehabilitation strategy leads to improved outcomes relative to usual care.DESIGN: A randomized controlled trial with 12 months of follow-up.SETTING: General community; 27 home care agencies.PARTICIPANTS: Three hundred four nondemented persons at lea... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Combined Modality Therapy', 'Connecticut', 'Female', 'Follow-Up Studies', 'Hip Fractures', 'Home Care Services', 'Humans', 'Male', 'Patient Selection', 'Time Factors', 'Treatment Outcome'] | 10,453,768 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186'], ['Z01.107.567.875.550.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['N02.421.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Identification and functional analysis of a KCNA5 mutation responsible for idiopathic atrial fibrillation]. | OBJECTIVE: To investigate the molecular mechanism of idiopathic atrial fibrillation (AF) associated with KCNA5 mutation.METHODS: The clinical data and blood samples from 130 unrelated subjects with idiopathic AF were collected and evaluated in contrast to 200 healthy individuals. The coding exons and the flanking intro... | ['Adult', 'Aged', 'Atrial Fibrillation', 'Base Sequence', 'Case-Control Studies', 'Female', 'Humans', 'Kv1.5 Potassium Channel', 'Male', 'Middle Aged', 'Mutation'] | 20,646,426 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.067.198', 'C23.550.073.198'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400.600.900.124.374', 'D12.776.157.5... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Three-dimensional imaging of cardiac mass lesions by transesophageal echocardiographic computed tomography. | Three-dimensional echocardiography is a new imaging technique that allows more realistic visualization of cardiac morphology. This study presents data about the diagnostic potentials of this technique concerning cardiac mass lesions, as well as its feasibility in clinical application. After the conventional investigati... | ['Echocardiography, Transesophageal', 'Feasibility Studies', 'Female', 'Heart Diseases', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Time Factors'] | 7,840,983 | [['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['M01.060.116.630'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Organization of the nervous tissue (hippocampus and septum) developing in the anterior eye chamber. III. Axonal processes and their synaptic endings. | Embryonal tissue of rat's septum and hippocampus developing in the anterior eye chamber for three to four months was investigated. Electron microscopic analysis of axonal processes and synaptic boutons is presented in this paper. Dense neuropil of the grafts includes myelinated and unmyelinated fibers. Some of them hav... | ['Animals', 'Anterior Chamber', 'Axons', 'Cell Differentiation', 'Hippocampus', 'Microscopy, Electron', 'Nerve Fibers, Myelinated', 'Nerve Regeneration', 'Rats', 'Rats, Inbred Strains', 'Septum Pellucidum', 'Synapses'] | 3,760,546 | [['B01.050'], ['A09.371.060.067'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G04.152'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E01.370.350.515.402', 'E05.595.402'], ['A08.675.542.512', 'A11.671.501.512', 'A11.671.514'], ['G11.561.585', 'G16.762.611'], ['B01.050.1... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal obesity has little effect on the immediate offspring but impacts on the next generation. | Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to developmental programming. Programming effects may be transmissible across generations through both maternal and paternal inheritance, although the mechanisms remain... | ['Animals', 'Birth Weight', 'Blood Glucose', 'Female', 'Glucose Tolerance Test', 'Hyperglycemia', 'Insulin Resistance', 'Male', 'Maternal Exposure', 'Mice', 'Mice, Inbred C57BL', 'Obesity', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Real-Time Polymerase Chain Reaction', 'Triglycerides', 'Weight Gain'] | 23,696,566 | [['B01.050'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['C18.452.394.952'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Relation between crust development and heterocyclic aromatic amine formation when air-roasting a meat cylinder. | The meat crust that develops during cooking is desired by consumers for its organoleptic properties, but it is also where heterocyclic aromatic amines (HAs) are formed. Here we measured HAs formation during the development of a colored crust on the surface of a beef meat piece. HAs formation was lower in the crust than... | ['Amines', 'Animals', 'Cattle', 'Cooking', 'Creatine', 'Heterocyclic Compounds', 'Hot Temperature', 'Meat'] | 27,451,229 | [['D02.092'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['J01.576.423.200.200'], ['D02.078.370.280', 'D12.125.373'], ['D03'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G07.203.300.600', 'J02.500.600']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Taxonomic revision of the cleptoparasitic bee genus Epiclopus Spinola, 1851 (Hymenoptera: Apidae: Ericrocidini). | A taxonomic revision of the cleptoparasitic bee genus Epiclopus Spinola is presented. The following species are recognized: Epiclopus gayi Spinola, E. lendlianus (Friese), E. wagenknechti (Ruiz) and E. ecphorus new species from northern Chile. Floral associations, hosts, distribution records and diagnoses of both sexes... | ['Animal Distribution', 'Animal Structures', 'Animals', 'Bees', 'Body Size', 'Chile', 'Female', 'Male', 'Organ Size'] | 25,283,096 | [['F01.145.113.069', 'G16.049'], ['A13'], ['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['Z01.107.757.235'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Assessment of deep venous thrombosis in the lower limbs and pelvis: MR venography versus duplex Doppler sonography. | OBJECTIVE: This study was designed to compare the diagnostic value of MR venography and color Doppler sonography in the assessment of deep venous thrombosis.SUBJECTS AND METHODS: MR venograms and color Doppler examinations were obtained in 37 patients either with suspected deep venous thrombosis of the lower limbs or p... | ['Adult', 'Aged', 'Female', 'Humans', 'Leg', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Pelvis', 'Phlebography', 'Prospective Studies', 'Sensitivity and Specificity', 'Thrombophlebitis', 'Ultrasonography, Doppler, Color', 'Veins'] | 8,819,396 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['M01.060.116.630'], ['A01.923.600'], ['E01.370.350.700.060.600', 'E01.370.370.050.600'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.5... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Adsorption and structural studies on activated carbons. | The porous structure of activated carbon is examined from the point of view of gas adsorption, and in relation to classical methods such as X-ray diffraction and electron microscopy. It is suggested that the different approaches to the problem of microporosity should provide complementary information, which can be usef... | ['Adsorption', 'Carbon', 'Microscopy, Electron', 'Models, Chemical', 'Surface Properties', 'X-Ray Diffraction'] | 596,323 | [['G01.030', 'G02.020'], ['D01.268.150'], ['E01.370.350.515.402', 'E05.595.402'], ['E05.599.495'], ['G02.860'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. | The aim of the present study was to examine the clinical significance of lymph node metastatic (LNM) foci in predicting the overall survival of oral squamous cell carcinoma (OSCC) patients with LNM. MMP-21 was screened based on the LNM animal model of OSCC. Then four proteins, matrix metalloproteinase (MMP)-2, MMP-21, ... | ['Aged', 'Aged, 80 and over', 'Animals', 'Carcinoma, Squamous Cell', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Kaplan-Meier Estimate', 'Lymphatic Metastasis', 'Male', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinases, Secreted', 'Middle Aged', 'Mouth Neoplasms', 'Prognosis', 'Vascular Endoth... | 24,700,287 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['C04.697.650.560', 'C23.550.727.650.560'], ['D08.811.277.656.300.4... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prevailing oxic environments in the Pacific Ocean during the mid-Cretaceous Oceanic anoxic event 2. | The occurrence of Oceanic Anoxic Event 2 (OAE2) 94 million years ago is considered to be one of the largest carbon cycle perturbations in the Earth's history. The marked increase in the spatial extent of the anoxic conditions in the world's oceans associated with OAE2 resulted in the mass accumulation of organic-rich s... | ['Anaerobiosis', 'Asia', 'Atlantic Ocean', 'Carbon Cycle', 'Carbon Isotopes', 'Europe', 'Fossils', 'Geologic Sediments', 'Geological Phenomena', 'North America', 'Oxidation-Reduction', 'Oxygen', 'Pacific Ocean'] | 21,407,200 | [['G02.111.062', 'G03.078'], ['Z01.252'], ['Z01.756.092'], ['G02.607.125', 'G16.500.150'], ['D01.268.150.075', 'D01.496.123'], ['Z01.542'], ['I01.076.368.584.311'], ['G01.311.330', 'G16.500.320'], ['G01.311'], ['Z01.107.567'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['Z01.756.700']] | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants. | One hundred and fifty endophytic actinomycetes were isolated from three pharmaceutical plants, Annonaceae squamosal, Camptotheca acuminate and Taxus chinensis. Bioactivity test showed that 72.4% of the endophytic actinomycetes displayed inhibition against more than one indicator microorganism. In total, 9.3 and 10.7% s... | ['Actinobacteria', 'Annonaceae', 'Anti-Bacterial Agents', 'Antioxidants', 'Bacterial Proteins', 'Bacterial Typing Techniques', 'Camptotheca', 'Cluster Analysis', 'DNA, Bacterial', 'DNA, Ribosomal', 'Genetic Variation', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Taxus'] | 19,657,693 | [['B03.510.024', 'B03.510.460.400.400.049'], ['B01.650.940.800.575.912.250.065'], ['D27.505.954.122.085'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D12.776.097'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['B01.650.940.800.575.912.250.778.188'], ['E05.318.740.250', 'N05.715.360.750.200... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[A pilot study on establishment of human/pig hematopoietic chimera model in fetal and neonatal pigs]. | This study was aimed to explore the feasibility of transplanting human cord blood stem cells (HSC) into pre-immune fetal and neonatal pigs, and to investigate the self-renewal of HSC in the recipient pigs. The fetus and neonate were manipulated in sterile separated room and human donor cells were injected into fetus vi... | ['Animals', 'Animals, Newborn', 'Cord Blood Stem Cell Transplantation', 'Fetus', 'Flow Cytometry', 'Humans', 'Leukocyte Common Antigens', 'Models, Animal', 'Pilot Projects', 'Swine', 'Transplantation Chimera', 'Transplantation, Heterologous'] | 16,129,058 | [['B01.050'], ['B01.050.050.282'], ['E02.095.147.500.500.312', 'E04.936.225.687.312'], ['A16.378'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cost effectiveness of a systematic guidelines-based approach to the prevention and management of vascular disease in a primary care setting. | BACKGROUND: In Ontario, Canada, the Comprehensive Vascular Disease Prevention and Management Initiative (CVDPMI) was undertaken to improve the vascular health in communities. The CVDPMI significantly improved cardiovascular (CV) risk factor profiles from baseline to follow-up visits including the 10 year Framingham Ris... | ['Cost-Benefit Analysis', 'Disease Management', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Economic', 'Morbidity', 'Ontario', 'Practice Guidelines as Topic', 'Primary Health Care', 'Prognosis', 'Vascular Diseases'] | 26,613,572 | [['N03.219.151.125'], ['N04.590.607'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.715.360.750.530.500', 'N06.850.520.830.500.600'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['Z01.107.567.1... | ['Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
@Home eTherapy Service for People with Common Mental Health Problems: an Evaluation. | BACKGROUND: Ensuring rapid access to psychological interventions is a priority of mental health services. The involvement of peer workers to support the delivery of more accessible treatment options such as computerized cognitive behaviour therapy (CCBT) is recognized.AIMS: To evaluate the implementation of a third sec... | ['Adult', 'Anxiety', 'Anxiety Disorders', 'Cognitive Behavioral Therapy', 'Depression', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Mental Health', 'Mental Health Services', 'Middle Aged', 'Referral and Consultation', 'Self Report', 'Telemedicine', 'Telephone', 'Treatment Outcome'] | 28,506,333 | [['M01.060.116'], ['F01.470.132'], ['F03.080'], ['F04.754.137.350'], ['F01.145.126.350'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['F04.408', 'N02.421.461'], ['M01.060.116.630'], ['N04.452.758.849'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N06.850.520.30... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Purification, primary structure, and antimicrobial activities of bovine apolipoprotein A-II. | We purified an antimicrobial protein of 76 residues, denoted bovine antimicrobial protein-1 (BAMP-1), from fetal calf serum using hydrophobic chromatography, gel filtration, and reverse-phase high-performance liquid chromatography. The amino acid sequence of BAMP-1 was similar to that of human apolipoprotein A-II (apo ... | ['Amino Acid Sequence', 'Animals', 'Anti-Bacterial Agents', 'Apolipoprotein A-II', 'Cattle', 'Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Humans', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid'] | 9,538,260 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D27.505.954.122.085'], ['D10.532.091.200.150', 'D12.776.070.400.200.150', 'D12.776.521.120.200.150'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400.250'], ['E05.196.181.400.300'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ribosome-lamella complexes in neoplastic hematopoietic cells. | The ultrastructural cellular inclusions referred to as ribosome-lamella complexes were observed in the neoplastic cell population of 4 patients with three types of hematopoietic malignancy, monoblastic leukemia. Waldenstrom's macroglobulinemia, and chronic lymphatic leukemia. The ultrastructural characteristics of the ... | ['Acute Disease', 'Cytoplasm', 'Endoplasmic Reticulum', 'Hematopoietic Stem Cells', 'Humans', 'Inclusion Bodies', 'Leukemia, Lymphoid', 'Leukemia, Monocytic, Acute', 'Ribosomes', 'Waldenstrom Macroglobulinemia'] | 166,565 | [['C23.550.291.125'], ['A11.284.430.214'], ['A11.284.430.214.190.875.248'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.420'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['C04.557.337.539.275.484'], ['A11.284.430.214.190.875.811'], ['C04.... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A rapid detection method for apoptosis and necrosis measurement using the Cellometer imaging cytometry. | Apoptosis and necrosis play an important role in various aspects of preclinical pharmaceutical drug discovery and validation. The ability to quickly determine the cytotoxic effect of chemical compounds on cancer cells allows researchers to efficiently identify potential drug candidates for further development in the ph... | ['Apoptosis', 'Humans', 'Image Cytometry', 'Jurkat Cells', 'Necrosis', 'Neoplasms'] | 21,910,006 | [['G04.146.954.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.386.400', 'E05.196.712.516.600.240.400', 'E05.200.500.386.400', 'E05.242.386.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['C23.550.717'], ['C04']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural studies on some dityrosine-cross-linked globular proteins: stability is weakened, but activity is not abolished. | We have carried out conformational and stability studies on three proteins that have previously been shown to undergo dityrosine (DT) cross-linking. They include the monomers and dimers of DT-cross-linked calmodulin and the dimers of bovine pancreatic ribonuclease A and bovine eye lens gammaB-Crystallin. In each of the... | ['Calmodulin', 'Crystallins', 'Dimerization', 'Protein Conformation', 'Ribonuclease, Pancreatic', 'Tyrosine'] | 11,101,314 | [['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D12.776.306.366'], ['G02.206', 'G03.230'], ['G02.111.570.820.709'], ['D08.811.277.352.355.350.715', 'D08.811.277.352.700.350.715'], ['D12.125.072.050.875']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and characterization of tri(ethylene oxide)-attached poly(amidoamine) dendrimer layers on gold. | This paper describes the synthesis of a tri(ethylene oxide)-attached fourth-generation poly(amidoamine) dendrimer (EO3-dendrimer) and the characterization of its layers on gold. NMR analysis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry revealed that about 61 amine groups of a G4 PAMA... | ['Adsorption', 'Animals', 'Avidin', 'Biotin', 'Blood Proteins', 'Cattle', 'Fluorescein-5-isothiocyanate', 'Gold', 'Magnetic Resonance Spectroscopy', 'Polymers', 'Serum Albumin, Bovine', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 15,120,276 | [['G01.030', 'G02.020'], ['B01.050'], ['D12.776.034.614.300', 'D12.776.256.159.157.663.300', 'D12.776.290.663.100', 'D12.776.395.175'], ['D03.383.129.308.080', 'D08.211.096'], ['D12.776.124'], ['B01.050.150.900.649.313.500.380.271'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Does depression decrease the moderating effect of self-efficacy in the relationship between illness perception and fear of progression in breast cancer? | OBJECTIVE: Fear of progression (FOP) is a prevalent concern among breast cancer patients that affect their adjustment to disease. This study examined whether self-efficacy moderates the effect of illness perception (IP) on FOP and whether the moderating effect of self-efficacy depends on the level of depressive symptom... | ['Adult', 'Aged', 'Breast Neoplasms', 'Cross-Sectional Studies', 'Depression', 'Disease Progression', 'Fear', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Quality of Life', 'Republic of Korea', 'Self Efficacy', 'Social Support', 'Surveys and Questionnaires'] | 28,816,370 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['C23.550.291.656'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Severe phimosis as a notable sequela of allogeneic stem cell transplantation in boys. | Hematopoietic SCT has improved the survival rates of patients with hematologic and metabolic disorders, as well as those with malignancy or immunodeficiency. Although various complications have been reported following allogeneic SCT, phimosis has rarely been reported, and the predisposing risk factors for phimosis have... | ['Adolescent', 'Antilymphocyte Serum', 'Child', 'Child, Preschool', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Infant', 'Japan', 'Male', 'Phimosis', 'Retrospective Studies', 'Risk Factors', 'Transplantation, Homologous'] | 17,572,709 | [['M01.060.057'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114.573.203', 'D20.215.401.203'], ['M01.060.406'], ['M01.060.406.448'], ['C20.452'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The prognostic significant of percentage drop in serum CEA post curative resection for colon cancer. | OBJECTIVE/BACKGROUND: This study aimed to analyze the hypothesis that increased percentage drop in serum CEA post curative resection for colon cancer is associated with improved survival.METHODS: Five hundred thirty three patients who underwent colon resection with a curative intent were retrospectively analyzed for th... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoembryonic Antigen', 'Colonic Neoplasms', 'Epidemiologic Methods', 'Female', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Postoperative Care', 'Preoperative Care', 'Prognosis', 'Young Adult'] | 21,094,039 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
DNA Barcodes Identify the Larvae and Unassociated Male of Three Onycholyda Sawflies (Hymenoptera, Pamphiliidae) from China. | A molecular analysis based on mitochondrial cytochrome oxidase subunit 1 (COI) gene sequences has indicated that larvae collected in Sichuan and Zhejiang Provinces, China, belong to Onycholyda xanthogaster Shinohara, 1999, and O. fulvicornis Shinohara, in Shinohara Wei, 2016 (Hymenoptera, Pamphiliidae), and that a male... | ['Animals', 'China', 'DNA Barcoding, Taxonomic', 'Hymenoptera', 'Larva', 'Male', 'Rosaceae'] | 29,690,248 | [['B01.050'], ['Z01.252.474.164'], ['E05.393.542.249', 'E05.393.760.700.149'], ['B01.050.500.131.617.720.500.500.875'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.650.940.800.575.912.250.859.937.500']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Cholesterol granuloma involving the temporal bone. | The cholesterol granuloma does not represent an independent clinical or pathological entity, rather it is a term used for the description of a tissue response of the temporal bone, to the presence of a particular foreign body, i.e., cholesterol crystals. Three factors are considered to play an important role in its dev... | ['Adult', 'Cholesterol', 'Ear Diseases', 'Foreign-Body Reaction', 'Granuloma', 'Humans', 'Male', 'Otitis Media', 'Radiography', 'Temporal Bone'] | 773,243 | [['M01.060.116'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C09.218'], ['C23.550.470.251', 'C26.392.560'], ['C15.604.515.292', 'C23.550.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.705.663'], ['E01.370.350.700'], ['A02.835.232.781.885']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Activating transcription factor 3 confers protection against ventilator-induced lung injury. | RATIONALE: Ventilator-induced lung injury (VILI) significantly contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury. Understanding the molecular basis for response to cyclic stretch (CS) and its derangement during high-volume ventilation is of high pri... | ['Activating Transcription Factor 3', 'Animals', 'Blotting, Western', 'Bronchoalveolar Lavage Fluid', 'Cells, Cultured', 'Cytokines', 'Disease Models, Animal', 'Gene Expression', 'Gene Expression Profiling', 'Humans', 'Lung', 'Mice', 'Mice, Knockout', 'Oligonucleotide Array Sequence Analysis', 'Random Allocation', 'Rat... | 20,413,626 | [['D12.776.260.108.061.875', 'D12.776.930.127.061.875'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.927.100.500'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ni(II)-catalyzed enantioselective Nazarov cyclizations. | Nazarov cyclizations are catalyzed by a dicationic Ni(II) complex containing the chiral tridentate phosphine Pigiphos; the catalyst exerts a high degree of torquoselectivity and affords the products in up to 88% ee. | ['Catalysis', 'Crystallography, X-Ray', 'Cyclization', 'Ketones', 'Ligands', 'Models, Molecular', 'Molecular Structure', 'Nickel', 'Stereoisomerism'] | 18,802,555 | [['G02.130'], ['E05.196.309.742.225'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.522'], ['D27.720.470.480'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behavioral modification of estuarine fish exposed to sulfur dioxide. | This study was designed to determine the avoidance responses of juvenile striped bass (Morone saxatilis) and Atlantic menhaden (Brevoortia tyrannus) exposed to sulfur dioxide (sulfite) at acclimation temperatures of 15, 20, 25, and 30 degrees C. Predictive models were developed and compared for each species at each acc... | ['Acclimatization', 'Animals', 'Avoidance Learning', 'Behavior, Animal', 'Chlorine', 'Fishes', 'Hydrogen-Ion Concentration', 'Sulfur Dioxide', 'Temperature'] | 6,492,212 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['D01.268.380.150', 'D01.362.225'], ['B01.050.150.900.493'], ['G02.300'], ['D01.362.810', 'D01.650.550.850.925', 'D01.875.825.925'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.1... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Testing the connection. While numerous medical tests are available, some are questioning how often they are necessary--and who will pay for them. | With an ever-widening array of medical tests and screenings available for patients, the debate over what tests are necessary, and who should get them, has taken on new intensity. "What we want is targeted screening. You can use things like family history and lifestyle to determine whether it's needed", says David Mongi... | ['Diagnostic Tests, Routine', 'Humans', 'Insurance, Health, Reimbursement', 'United States', 'Unnecessary Procedures'] | 20,196,371 | [['E01.370.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.480', 'N03.219.521.710'], ['Z01.107.567.875'], ['N02.421.380.450.500', 'N05.300.150.395.450.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Mesangial cell regeneration from exogenous stromal progenitor by utilizing embryonic kidney. | Kidney regenerative medicine is expected to be the solution to the shortage of organs for transplantation. In a previous report, we transplanted exogenous renal progenitor cells (RPCs) including nephron progenitor cells (NPCs), stromal progenitor cells (SPCs), and the ureteric bud (UB) into the nephrogenic zone of anim... | ['Animals', 'Cell Differentiation', 'Cell Lineage', 'Female', 'Green Fluorescent Proteins', 'Humans', 'Kidney', 'Male', 'Mesangial Cells', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Models, Animal', 'Pregnancy', 'Regeneration', 'Regenerative Medicine', 'Stem Cell Transplantation', 'Stromal Cells'] | 31,623,827 | [['B01.050'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['A05.810.453.324.359.620', 'A05.810.453.736.520.620', 'A11.329.228.950'], ['B01.050.150.900.649.313.992.635.505.500'], ['B0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Derivation of a rigorous equation for the calculation of the F-value in isothermal sterilization processes. | The use of simplified equations utilizing the Z- and F-values to calculate the level of sterilization achieved in isothermal processes is very common in industry. This method assumes that the Z-value is independent of temperature. This is a simplifying assumption that is not based on a physically realistic microbial in... | ['Biotechnology', 'Chemistry, Pharmaceutical', 'Kinetics', 'Mathematical Computing', 'Sterilization', 'Temperature'] | 8,071,818 | [['H01.158.550', 'J01.897.120'], ['H01.158.703.007', 'H01.181.466'], ['G01.374.661', 'G02.111.490'], ['L01.224.680'], ['N06.850.780.200.450.850'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Gatekeeping--clinical and administrative issues. | Most gatekeeper-based models of health care delivery utilize primary care physicians for authorizing services, screening referrals, managing cases and monitoring costs. Issues in four major areas related to gatekeeping have arisen in such systems: those affecting patients primarily, those affecting physicians primarily... | ['Adult', 'Female', 'Health Maintenance Organizations', 'Humans', 'Infant, Newborn', 'Male', 'Primary Health Care', 'Referral and Consultation', 'Washington'] | 3,765,611 | [['M01.060.116'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N04.590.233.727'], ['N04.452.758.849'], ['Z01.107.567.875.560.900', 'Z01.107.567.875.580.900']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
SII-projecting neurons in the rat thalamus: a single- and double-retrograde-tracing study. | Experiments were performed on adult albino rats, using single-labeling (free horseradish peroxidase [HRP] or wheatgerm agglutinin conjugated to HRP [WGA:HRP]) and double-labeling (fluorescent dyes) techniques to investigate the thalamic projections to the secondary somatosensory cortex (SII) and to demonstrate the pres... | ['Afferent Pathways', 'Animals', 'Axons', 'Brain Mapping', 'Forelimb', 'Horseradish Peroxidase', 'Neurons', 'Rats', 'Rats, Inbred Strains', 'Somatosensory Cortex', 'Thalamic Nuclei', 'Wheat Germ Agglutinins'] | 3,589,289 | [['A08.612.220'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A13.395'], ['D08.811.682.732.512'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of pre-fermentation and pulsed-electric-field treatment of primary sludge in microbial electrochemical cells. | The aim of this study was to investigate the combination of two technologies - pulsed electric field (PEF) pre-treatment and semi-continuous pre-fermentation of primary sludge (PS) - to produce volatile fatty acids (VFAs) as the electron donor for microbial electrolysis cells (MECs). Pre-fermentation with a 3-day solid... | ['Bioelectric Energy Sources', 'Biological Oxygen Demand Analysis', 'Bioreactors', 'Electricity', 'Electrochemical Techniques', 'Fatty Acids, Volatile', 'Fermentation', 'Hydrogen-Ion Concentration', 'Methane', 'Sewage'] | 26,159,378 | [['E07.305.124.150'], ['N06.850.460.350.080.500', 'N06.850.780.375.349'], ['E07.115', 'J01.897.120.115'], ['G01.358.500.249'], ['E05.301'], ['D10.251.400'], ['G02.111.158.249', 'G03.191.249'], ['G02.300'], ['D02.455.326.146.571'], ['D20.944.932.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Analysis of the derangement of the pancreatic microcirculation in a rat caerulein pancreatitis model using an intravital microscope system. | In order to clarify the derangement of the pancreatic microcirculation in acute pancreatitis, the pancreatic microcirculation in caerulein pancreatitis was monitored intravitally and the roles of bradykinin and nitric oxide were examined using bradkykinin B2 receptor antagonist, HOE140. Under an intravital microscope, ... | ['Acute Disease', 'Animals', 'Arterioles', 'Body Water', 'Ceruletide', 'Leukocytes', 'Male', 'Microcirculation', 'Microscopy, Fluorescence', 'Microscopy, Video', 'Nitrates', 'Nitrites', 'Pancreas', 'Pancreatitis', 'Rats', 'Rats, Wistar'] | 9,111,766 | [['C23.550.291.125'], ['B01.050'], ['A07.015.114.060', 'A07.015.461.080'], ['A12.207.200'], ['D12.644.456.241'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['G09.330.100.645'], ['E01.370.350.515.458', 'E05.595.458'], ['E01.370.350.515.690', 'E05.595.690', 'J01.897.280.500.898.475', 'L01.178.820.090.898.475', 'L... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Use of the dynamic gastro-intestinal model TIM to explore the survival of the yogurt bacterium Streptococcus thermophilus and the metabolic activities induced in the simulated human gut. | Streptococcus thermophilus, a lactic acid bacterium used to produce yogurts and cheeses is more and more considered for its potential probiotic properties. This implies that additional information should be obtained regarding its survival and metabolic activity in the human Gastro-Intestinal Tract (GIT). In this study,... | ['Adaptation, Physiological', 'Animals', 'Digestion', 'Gastric Acid', 'Genes, Bacterial', 'Humans', 'Microbial Viability', 'Milk', 'Models, Anatomic', 'Probiotics', 'Streptococcus thermophilus', 'Upper Gastrointestinal Tract', 'Urease', 'Yogurt'] | 26,611,166 | [['G07.025', 'G16.012.500'], ['B01.050'], ['G07.203.650.250', 'G10.261.190'], ['A12.200.307.603'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.580'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Effect of a simple information booklet on pain persistence after an acute episode of low back pain: a non-randomized trial in a primary care setting. | OBJECTIVE: Mass-media campaigns have been known to modify the outcome of low back pain (LBP). We assessed the impact on outcome of standardized written information on LBP given to patients with acute LBP.DESIGN: A 3-month pragmatic, multicenter controlled trial with geographic stratification.SETTING: Primary care pract... | ['Adult', 'Fear', 'France', 'Humans', 'Low Back Pain', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Pain Measurement', 'Pamphlets', 'Patient Education as Topic', 'Primary Health Care', 'Prospective Studies', 'Sick Leave', 'Surveys and Questionnaires', 'Treatment Outcome'] | 17,684,553 | [['M01.060.116'], ['F01.470.361'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E01.370.600.550.324'], ['L01.178.682.707'], ['I02.233.332.500', 'N02.421.726.407.680'], ['N04.590.23... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Exogenous cortisol shifts a motivated bias from fear to anger in spatial working memory for facial expressions. | Studies assessing processing of facial expressions have established that cortisol levels, emotional traits, and affective disorders predict selective responding to these motivationally relevant stimuli in expression specific manners. For instance, increased attentional processing of fearful faces (attentional bias for ... | ['Adolescent', 'Adult', 'Anger', 'Anxiety', 'Discrimination Learning', 'Double-Blind Method', 'Facial Expression', 'Fear', 'Humans', 'Hydrocortisone', 'Male', 'Memory', 'Pattern Recognition, Visual', 'Placebos', 'Recognition, Psychology', 'Self-Assessment'] | 17,088,024 | [['M01.060.057'], ['M01.060.116'], ['F01.470.093'], ['F01.470.132'], ['F02.463.425.280'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.600.225', 'F01.145.209.530.385'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase. | Adsorption of enzymes to nanoparticles and the mechanisms responsible for enzyme activity modulation of adsorbed enzymes are not well understood. In this work, gold nanoparticles were used for electrostatic adsorption of a plant-derived laccase. Adsorption constants were determined by four independent techniques: dynam... | ['Adsorption', 'Gold', 'Hydrazones', 'Hydrogen-Ion Concentration', 'Kinetics', 'Laccase', 'Metal Nanoparticles', 'Toxicodendron'] | 29,882,945 | [['G01.030', 'G02.020'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D02.442.288'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.494'], ['J01.637.512.600.500'], ['B01.650.940.800.575.912.250.044.744']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Impact of frequent testing on the transmission of HIV and N. gonorrhoeae | OBJECTIVES: To investigate the impact and efficiency of combined testing for HIV and other STIs on HIV and STI transmission among men who have sex with men (MSM) and to assess what subgroups of MSM should be targeted for frequent testing.METHODS: We developed an agent-based transmission model that simulates infection w... | ['Adolescent', 'Adult', 'Condoms', 'Gonorrhea', 'HIV Infections', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Models, Theoretical', 'Sexual Behavior', 'Sexual and Gender Minorities', 'Young Adult'] | 31,801,895 | [['M01.060.057'], ['M01.060.116'], ['E07.190.270.150'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01.778.281.401', 'C12.294.668.281.401', 'C13.351.500.711.281.401'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Application of infrared light for in vivo neural stimulation. | A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation ... | ['Action Potentials', 'Animals', 'Dose-Response Relationship, Radiation', 'Infrared Rays', 'Muscle Contraction', 'Radiation Dosage', 'Rats', 'Rats, Sprague-Dawley', 'Sciatic Nerve'] | 16,409,069 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.40... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ultrasound-guided supraclavicular brachial plexus block in upper limb surgery: outcomes and patient satisfaction. | We examined the outcomes and levels of patient satisfaction in 202 consecutive cases of ultrasound-guided supraclavicular brachial plexus block (SBPB) in upper limb surgery performed between September 2007 and March 2010. All blocks were performed by orthopaedic surgeons using ultrasound visualisation with a high-frequ... | ['Adult', 'Anesthetics, Local', 'Brachial Plexus', 'Clavicle', 'Cohort Studies', 'Female', 'Humans', 'Middle Aged', 'Nerve Block', 'Pain Measurement', 'Patient Satisfaction', 'Prognosis', 'Retrospective Studies', 'Risk Assessment', 'Surveys and Questionnaires', 'Treatment Outcome', 'Ultrasonography, Interventional', 'U... | 24,891,581 | [['M01.060.116'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['A08.800.800.720.050'], ['A02.835.232.087.227'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E03.155.086.71... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Methods for adjusting for bias due to crossover in oncology trials. | Trials of new oncology treatments often involve a crossover element in their design that allows patients receiving the control treatment to crossover to receive the experimental treatment at disease progression or when sufficient evidence about the efficacy of the new treatment is achieved. Crossover leads to contamina... | ['Antineoplastic Agents', 'Bias', 'Cost-Benefit Analysis', 'Cross-Over Studies', 'Humans', 'Indoles', 'Kaplan-Meier Estimate', 'Models, Statistical', 'Neoplasms', 'Neuroendocrine Tumors', 'Pancreatic Neoplasms', 'Pyrroles', 'Randomized Controlled Trials as Topic', 'Sunitinib'] | 24,595,585 | [['D27.505.954.248'], ['N05.715.350.150', 'N06.850.490.500'], ['N03.219.151.125'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['E05.318.740.500', '... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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