Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism. | The Y-family DNA polymerase Dpo4, from the archaeon bacterium Sulfolobus solfataricus, is a member of the DinB family, which also contains human Pol kappa. It has a spacious active site that can accommodate two templating bases simultaneously, with one of them skipped by the incoming dNTP. Assays of single dNTP inserti... | ['Archaeal Proteins', 'Base Pairing', 'Base Sequence', 'Benzopyrenes', 'Binding Sites', 'Computer Simulation', 'DNA-Directed DNA Polymerase', 'Deoxyadenine Nucleotides', 'Deoxyguanosine', 'Models, Molecular', 'Molecular Structure', 'Nucleotides', 'Substrate Specificity', 'Sulfolobus solfataricus'] | 18,260,644 | [['D12.776.090'], ['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D02.455.426.559.847.799.306', 'D04.615.799.306'], ['G02.111.570.120'], ['L01.224.160'], ['D08.811.913.696.445.308.300'], ['D03.633.100.759.646.138.410', 'D13.695.201.100', 'D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Export of arsenic from forested catchments under easing atmospheric pollution. | Massive lignite burning in Central European power plants peaked in the 1980s. Dissolved arsenic in runoff from upland forest ecosystems is one of the ecotoxicological risks resulting from power plant emissions. Maxima in As concentrations in runoff from four forest catchments have increased 2-5 times between 1995 and 2... | ['Air Pollution', 'Arsenic', 'Atmosphere', 'Czech Republic', 'Geography', 'Hydrogen-Ion Concentration', 'Models, Chemical', 'Particulate Matter', 'Picea', 'Soil', 'Time Factors', 'Trees'] | 18,939,545 | [['N06.850.460.100'], ['D01.268.513.249'], ['G16.500.275.063', 'N06.230.300.100'], ['Z01.542.248.395'], ['H01.277.500'], ['G02.300'], ['E05.599.495'], ['D20.633'], ['B01.650.940.800.575.912.625.875.755'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['G01.910.857'], ['B01.650.915']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Ecology and signal structure drive the evolution of synchronous displays. | Animal synchrony is found in phylogenetically distant animal groups, indicating behavioral adaptations to different selective pressures and in different signaling modalities. A notable example of synchronous display is found in fiddler crabs in that males wave their single enlarged claw during courtship. They present s... | ['Animal Communication', 'Animals', 'Australia', 'Biological Evolution', 'Brachyura', 'Brazil', 'Ecosystem', 'Life History Traits', 'Male', 'Panama', 'Phylogeny', 'Sexual Behavior, Animal'] | 31,503,329 | [['F01.145.113.055'], ['B01.050'], ['Z01.639.100', 'Z01.678.100.373'], ['G05.045', 'G16.075'], ['B01.050.500.131.365.190.110'], ['Z01.107.757.176'], ['G16.500.275.157', 'N06.230.124'], ['G05.045.513', 'G16.575'], ['Z01.107.169.772'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['F01.145.113.252.748']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Fenton's pre-treatment of mature landfill leachate. | The aim of this study was to check the effectiveness of the Fenton's reagent (Fe2+ + H2O2 + H+) for the pre-treatment of a municipal landfill leachate with the objective of improving its overall biodegradability, evaluated in terms of BOD5/COD ratio, up to a value compatible with biological treatment. The leachate came... | ['Hydrogen Peroxide', 'Hydrogen-Ion Concentration', 'Iron', 'Italy', 'Kinetics', 'Oxygen', 'Refuse Disposal', 'Water Pollutants', 'Water Purification'] | 14,637,358 | [['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['G02.300'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['Z01.542.489'], ['G01.374.661', 'G02.111.490'], ['D01.268.185.550', 'D01.362.670'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['D2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Asymptomatic paraganglioma of the bladder wall with unusual extensive submucous vascular proliferation]. | Paraganglioma of the urinary bladder is a very rare tumor, which is usually diagnosed on the basis of its endocrine symptoms because of the excretion of vasoactive substances. One case of asymptomatic paraganglioma detected by chance is described, it was misdiagnosed as hemangioma because of its marked suburothelial ve... | ['Diagnostic Imaging', 'Humans', 'Male', 'Middle Aged', 'Paraganglioma', 'Urinary Bladder Neoplasms'] | 2,219,604 | [['E01.370.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.465.625.650.700', 'C04.557.580.625.650.700'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', 'C13.351.968.829.707']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparison of liver ultrastructure in salicylate intoxication and Reye's syndrome. | All childhood liver biopsy specimens from The Cincinnati Children's Hospital Research Foundation which had been prepared for light and electron microscopy were reviewed to identify biopsies from children with salicylate intoxication. Only two cases of primary salicylate intoxication were identified. The histopathology ... | ['Child', 'Child, Preschool', 'Female', 'Humans', 'Liver', 'Male', 'Mitochondria, Liver', 'Reye Syndrome', 'Salicylates', 'Salicylic Acid'] | 6,745,858 | [['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['C06.552.241.649', 'C10.228.140.163.780', 'C18.452.132.780'], ['D02.241.223.100.300.595', 'D02.241.511.390.595', 'D02.455.426.559.389.127.281.595', 'D02.455.4... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cation coordination induced modulation of the anion sensing properties of a ferrocene-imidazophenanthroline dyad: multichannel recognition from phosphate-related to chloride anions. | A new chemosensor molecule 1 based on a ferrocene-imidazophenanthroline dyad, effectively recognizes aqueous hydrogenpyrophosphate and the organic anions ADP and ATP through three different channels. A cathodic shift of the ferrocene/ferrocenium oxidation wave (Delta E 1/2 ranging from -130 mV for hydrogenpyrophosphate... | ['Anions', 'Cations', 'Chlorides', 'Ferrous Compounds', 'Magnetic Resonance Spectroscopy', 'Metallocenes', 'Oxidation-Reduction', 'Phenanthrolines', 'Phosphates', 'Spectrometry, Fluorescence'] | 18,433,179 | [['D01.248.497.158'], ['D01.248.497.300'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D01.490.200'], ['E05.196.867.519'], ['D02.691.657'], ['G02.700', 'G03.295.531'], ['D03.633.300.669'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The impact of olanzapine, risperidone, or haloperidol on the cost of schizophrenia care in a medicaid population. | OBJECTIVE: The objective of this study was to assess the impact of medication treatment on Medicaid costs for persons with schizophrenia.METHODS: Michigan Medicaid claims from January 1995 through September 1998 were analyzed for persons with schizophrenia diagnoses who initiated olanzapine (n = 458), risperidone (n = ... | ['Adult', 'Antipsychotic Agents', 'Benzodiazepines', 'Cost-Benefit Analysis', 'Drug Costs', 'Female', 'Haloperidol', 'Health Care Costs', 'Humans', 'Least-Squares Analysis', 'Linear Models', 'Male', 'Medicaid', 'Mental Health Services', 'Michigan', 'Olanzapine', 'Risperidone', 'Schizophrenia', 'United States'] | 14,720,128 | [['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.633.100.079.080'], ['N03.219.151.125'], ['N03.219.151.400.350', 'N05.300.375.300'], ['D02.522.352.506'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis. | We have shown that an altered tissue redox environment in mice lacking either murine beta Hemoglobin major (HgbâmaKO) or minor (HgbâmiKO) regulates inflammation. The REDOX environment in marrow stem cell niches also control differentiation pathways. We investigated osteoclastogenesis (OC)/osteoblastogenesis (OB), in bo... | ['Animals', 'Bone and Bones', 'Cell Differentiation', 'Cells, Cultured', 'Cellular Microenvironment', 'Female', 'Fetal Hemoglobin', 'Gene Expression Regulation, Developmental', 'Male', 'Mesenchymal Stem Cells', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Osteoblasts', 'Osteogenesis', 'Osteop... | 29,477,972 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['G04.152'], ['A11.251'], ['G04.366'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['G05.308.310'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients. | The transcription factor SOX4 has functional importance in foetal lung maturation and tumorigenesis in a number of cancers. However, its biological functions in the progression of lung tumorigenesis remain unclear. In this study, we found that the expression levels of SOX4 mRNA and protein were significantly higher in ... | ['Animals', 'Apoptosis', 'Blotting, Western', 'Cell Proliferation', 'Female', 'Humans', 'Immunohistochemistry', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Microscopy, Electron, Transmission', 'Middle Aged', 'Real-Time Polymerase Chain Reaction', 'SOXC Transcription Factors'] | 25,565,486 | [['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrostatic Charge on Flying Hummingbirds and Its Potential Role in Pollination. | Electrostatic phenomena are known to enhance both wind- and insect-mediated pollination, but have not yet been described for nectar-feeding vertebrates. Here we demonstrate that wild Anna's Hummingbirds (Calypte anna) can carry positive charges up to 800 pC while in flight (mean ± s.d.: 66 ± 129 pC). Triboelectric char... | ['Animals', 'Birds', 'Flight, Animal', 'Pollination', 'Static Electricity'] | 26,421,845 | [['B01.050'], ['B01.050.150.900.248'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['G08.686.784.743', 'G15.776'], ['G01.358.500.249.820']] | ['Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Macrophage activation by synthetic peptides. I. Kinetic changes in the transport of fluorescein anions across the plasma membrane of macrophages]. | As shown by cytofluorimetric technique, fluorescein anions formed in macrophages due to hydrolysis of fluorescein diacetate (FDA) release into the extracellular medium through the probenecid-inhibitable transport system of organic acids. Technical procedures have been elaborated to record separately the process of FDA ... | ['Amino Acid Sequence', 'Animals', 'Anions', 'Biological Transport, Active', 'Cell Membrane', 'Dose-Response Relationship, Drug', 'Flow Cytometry', 'Fluoresceins', 'Hydrolysis', 'Macrophage Activation', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Naphthol AS D Esterase', 'Oligopeptides', 'P... | 2,623,768 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D01.248.497.158'], ['G03.143.310'], ['A11.284.149'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Free radicals induce increased lysis of red blood cells after haemodialysis. | This study investigates the role of oxidative damage causing haemolysis as a possible factor contributing to reduced red blood cell survival and thereby to renal anaemia in patients on chronic haemodialysis. Oxidative damage and haemolysis may be initiated by lipid peroxidation. In this study primary initiators of lipi... | ['Adult', 'Aged', 'Anemia', 'Cell Survival', 'Erythrocytes', 'Female', 'Free Radicals', 'Hemolysis', 'Humans', 'Male', 'Middle Aged', 'Renal Dialysis', 'Renal Insufficiency'] | 23,275,994 | [['M01.060.116'], ['M01.060.116.100'], ['C15.378.071'], ['G04.346'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D01.339', 'D02.389'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.870.300', 'E02.912.800'], ['C12.777.419.780', 'C13.351.968.419.780']... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Substrate-mediated gene delivery from glycol-chitosan/hyaluronic acid polyelectrolyte multilayer films. | Substrate-mediated transfection is one of the key strategies for localized gene delivery. Layer-by-layer (LbL) polyelectrolyte deposition is a promising technique which enables controlled delivery of a number of biofactors, including nucleic acids. Here, we embed lipoplexes containing plasmid DNA within polyelectrolyte... | ['Animals', 'DNA', 'Electrolytes', 'Gene Transfer Techniques', 'HEK293 Cells', 'Humans', 'Hyaluronic Acid', 'Mice', 'NIH 3T3 Cells', 'Transfection'] | 23,281,737 | [['B01.050'], ['D13.444.308'], ['D01.248'], ['E05.393.350'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.373.475'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.251.210.100.550', 'A11.329.228.100.550'], ['E05.393.350.810', 'G05.728.860']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pattern of chronic liver disease in Omani children--a clinicopathological review. | OBJECTIVE: To determine the pattern of chronic liver disease in Omani children.STUDY DESIGN: Seventy six children [43M : 33F] aged 4 days to 10 years, referred to the Paediatric Gastroenterology clinic of the Sultan Qaboos University Hospital, Muscat, Oman, between 1995--2000 for evaluation of liver disease were studie... | ['Age Distribution', 'Biliary Atresia', 'Biopsy', 'Child', 'Child, Preschool', 'Chronic Disease', 'Female', 'Glycogen Storage Disease', 'Hepatitis', 'Hepatomegaly', 'Hospitals, University', 'Humans', 'Infant', 'Infant, Newborn', 'Jaundice', 'Liver Cirrhosis', 'Liver Diseases', 'Male', 'Nigeria', 'Patient Selection', 'P... | 15,287,298 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C06.130.120.123', 'C06.198.125', 'C16.131.314.125'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['C16.3... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
An immunochemical comparison of human myelin basic protein and its modified, citrullinated form, C8. | An immunochemical analysis was conducted to compare the C1 isomer of human myelin basic protein (MBP) with the newly described and less cationic, citrullinated isomer of MBP referred to as C8. Ten polyclonal antisera directed at multiple epitopes or restricted regions of MBP were used in radioimmunoassays to examine MB... | ['Adult', 'Animals', 'Citrulline', 'Humans', 'Immunochemistry', 'Myelin Basic Protein', 'Protein Processing, Post-Translational', 'Rabbits', 'Sheep'] | 1,370,666 | [['M01.060.116'], ['B01.050'], ['D12.125.095.226'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.486', 'H01.181.122.605', 'H02.403.044.500'], ['D12.776.543.620.540', 'D12.776.631.580.510'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05.308.670.600'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
High resolution melting analysis: a rapid screening and typing tool for common â-thalassemia mutation in Chinese population. | â-thalassemia is a common inherited disorder worldwide including southern China, and at least 45 distinct â-thalassemia mutations have been identified in China. High-resolution melting (HRM) assay was recently introduced as a rapid, inexpensive and effective method for genotyping. However, there was no systemic study o... | ['Asian Continental Ancestry Group', 'China', 'DNA', 'Genetic Testing', 'Genotyping Techniques', 'Geography', 'Humans', 'Mutation', 'Nucleic Acid Denaturation', 'Reproducibility of Results', 'beta-Thalassemia'] | 25,089,872 | [['M01.686.508.200'], ['Z01.252.474.164'], ['D13.444.308'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['E05.393.442'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['E05.393.640', 'G02.111.603', 'G05.627'], ['E05.318.370.725', 'E05... | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
[Pathological anatomy of the pseudolymphoma and lymphoma of the digestive tract (author's transl)]. | On the basis of 44 cases of pseudolymphomas and lymphomas of the gastro-intestinal tract the authors demonstrate the histological properties of these diseases with particular reference to the differential diagnosis. The most important features are the behaviour of the argyrophilic fibres and the occurrence or absence o... | ['Adult', 'Aged', 'Biopsy', 'Female', 'Gastrointestinal Neoplasms', 'Humans', 'Lymphoma', 'Male', 'Middle Aged'] | 7,447,627 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386', 'C15.604.515.569', 'C2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vitamin D receptor inhibits nuclear factor êB activation by interacting with IêB kinase â protein. | 1,25-Dihydroxyvitamin D (1,25(OH)2D3) is known to suppress NF-êB activity, but the underlying mechanism remains poorly understood. Here we show that the vitamin D receptor (VDR) physically interacts with IêB kinase â (IKKâ) to block NF-êB activation. 1,25(OH)2D3 rapidly attenuates TNFá-induced p65 nuclear translocation... | ['Active Transport, Cell Nucleus', 'Animals', 'Calcitriol', 'Cell Nucleus', 'HEK293 Cells', 'Humans', 'I-kappa B Kinase', 'Mice', 'Mice, Knockout', 'NF-kappa B p50 Subunit', 'Peptide Mapping', 'Phosphorylation', 'Protein Structure, Tertiary', 'Receptors, Calcitriol', 'Transcription Factor RelA'] | 23,671,281 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.31... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of denervation on a steady electric current generated at the end-plate region of rat skeletal muscle. | An electric current flows continuously out of the synaptic region of rat lumbrical muscle fibres. It is generated apparently as a result of a non-uniform Cl- conductance (GCl), with GCl being lowest at the end-plate. We investigated the effects of denervation on this current. The current persisted with little change af... | ['Action Potentials', 'Animals', 'Anthracenes', 'Barium', 'Carbachol', 'Chlorides', 'Furosemide', 'Motor Endplate', 'Muscle Denervation', 'Muscles', 'Neuromuscular Junction', 'Potassium', 'Rats', 'Sodium', 'Tetrodotoxin', 'Time Factors'] | 3,746,683 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D02.455.426.559.847.117', 'D04.615.117'], ['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D02.065.884.725.300', 'D02.092.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. | The IL-1 family members IL-36á (IL-1F6), IL-36â (IL-1F8), and IL-36ã (IL-1F9) and the receptor antagonist IL-36Ra (IL-1F5) constitute a novel signaling system that is poorly understood. We now show that these cytokines have profound effects on the skin immune system. Treatment of human keratinocytes with IL-36 cytokine... | ['Allografts', 'Animals', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cell Line', 'Cell Movement', 'Cell Proliferation', 'Cytokines', 'Dendritic Cells', 'Dermatitis', 'Inflammation', 'Interleukin-1', 'Keratinocytes', 'Mice', 'Monocytes', 'Skin', 'Skin Transplantation'] | 24,829,417 | [['A01.941.500'], ['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Personality and community prevention teams: Dimensions of team leader and member personality predicting team functioning. | The predictors and correlates of positive functioning among community prevention teams have been examined in a number of research studies; however, the role of personality has been neglected. In this study, we examined whether team member and leader personality dimensions assessed at the time of team formation predicte... | ['Adult', 'Family Health', 'Group Processes', 'Health Care Coalitions', 'Humans', 'Interpersonal Relations', 'Leadership', 'Middle Aged', 'Personality', 'Poverty Areas', 'Public Health Administration', 'School Health Services', 'Substance-Related Disorders'] | 18,829,112 | [['M01.060.116'], ['N01.400.300'], ['F01.829.316'], ['N03.540.452.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.752.609'], ['M01.060.116.630'], ['F01.752'], ['I01.880.853.996.535.550', 'N01.824.600.550'], ['N04.452.794'], ['N02.421.726.809'], ['C25.775', 'F03.900']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A score predicts failure of reperfusion after fibrinolytic therapy for acute myocardial infarction. | BACKGROUND: A rapid, accurate, noninvasive means of predicting the likelihood of failure to achieve Thrombolysis In Myocardial Infarction (TIMI) grade 3 flow within 90 minutes after the start of fibrinolysis with streptokinase could help to identify patients who might benefit from additional therapies that aim to prese... | ['Biomarkers', 'Coronary Circulation', 'Creatine Kinase', 'Creatine Kinase, MB Form', 'Electrocardiography', 'Female', 'Humans', 'Isoenzymes', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Myocardial Infarction', 'Myocardial Reperfusion', 'Myoglobin', 'Risk Assessment', 'Sensitivity and Specificity', 'Streptokinase'... | 12,660,675 | [['D23.101'], ['G09.330.100.324'], ['D08.811.913.696.640.150'], ['D08.811.913.696.640.150.625'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Three-dimensional videomonitor in microsurgery. | The operation microscope was equipped with two small camera heads on both sides, with a 35-mm still camera, and with or without a binocular observer tube. These camera heads were connected with a 3-dimensional (3D) converter. The operator can observe the 3D images of the operation field on a TV monitor through polariza... | ['Equipment Design', 'Humans', 'Image Processing, Computer-Assisted', 'Microsurgery', 'Neurosurgery', 'Photography', 'Video Recording'] | 8,350,974 | [['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E04.494', 'E05.591.580'], ['H02.403.810.425'], ['E01.370.350.600', 'E05.712'], ['L01.280.960']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. | We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synte... | ['Base Composition', 'Biological Evolution', 'Centromere', 'Chromosome Inversion', 'Chromosome Mapping', 'Computational Biology', 'Fungal Proteins', 'Gene Duplication', 'Gene Order', 'Genes, Fungal', 'Genome, Fungal', 'Molecular Sequence Data', 'Open Reading Frames', 'Saccharomyces cerevisiae', 'Saccharomycetales', 'Se... | 15,001,715 | [['G02.111.080'], ['G05.045', 'G16.075'], ['A11.284.430.106.279.345.190.160.165', 'G05.360.160.165'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['D12.776.354'], ['G05.365.590.320', 'G05.558.320'], ['G05.340'], ['G05.360.340... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Socialization to violence among the aged. | This paper addresses the issue of the attitudinal consequences of fear and victimization by focusing on the degree to which people of different ages expresses approval of violent behavior. It is our argument that the experience of victimization socializes the individual to a view as constituting an effective strategy f... | ['Adolescent', 'Adult', 'Aged', 'Attitude', 'Fear', 'Female', 'Humans', 'Male', 'Middle Aged', 'Violence'] | 7,229,283 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F01.100'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.198.240.856', 'I01.880.735.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Identification of nitroimidazole-oxime derivatives targeting the polo-box domain of polo-like kinase 1. | Recent progress in the development of small molecular skeleton-derived polo-like kinase (PLK1) catalytic domain (KD) inhibitors has led to the synthesis of multiple ligands with high binding affinity. However, few systematic analyses have been conducted to identify key PLK1-PBD domain and characterize their interaction... | ['Antineoplastic Agents', 'Apoptosis', 'Cell Cycle Proteins', 'Cell Proliferation', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Humans', 'Molecular Docking Simulation', 'Molecular Structure', 'Nitroimidazoles', 'Oximes', 'Protein Kinase Inhibitors', 'Protein-Serine-Threonine Kinases', 'Prot... | 29,100,732 | [['D27.505.954.248'], ['G04.146.954.035'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595.249', 'L01.224.160.249'], ['G02.111.570... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation. | Acoustic attenuation represents the energy loss of the propagating wave through biological tissues and plays a significant role in both therapeutic and diagnostic ultrasound applications. Estimation of acoustic attenuation remains challenging but critical for tissue characterization. In this study, an attenuation estim... | ['Acoustics', 'Animals', 'Dogs', 'Elasticity Imaging Techniques', 'High-Intensity Focused Ultrasound Ablation', 'In Vitro Techniques', 'Liver', 'Models, Theoretical', 'Phantoms, Imaging', 'Radiation Dosage'] | 26,371,501 | [['H01.671.031'], ['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.350.850.270'], ['E02.565.280.945.399', 'E04.014.380'], ['E05.481'], ['A03.620'], ['E05.599'], ['E07.671'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A technique for the preparation of cross-sectional TEM samples of ZnSe/GaAs heterostructures which eliminates process-induced defects. | Cross-sectional transmission electron microscopy (TEM) sample preparation of ZnSe/GaAs epitaxial films is investigated. Conventional argon ion milling is shown to produce a high density (approximately 5-8 x 10(11)/cm2) of small (diameter approximately 60-80 A) extended defects (stacking faults, microtwins, double posit... | ['Arsenic', 'Freeze Etching', 'Gallium', 'Image Processing, Computer-Assisted', 'Microscopy, Electron', 'Selenium', 'Semiconductors', 'Surface Properties', 'Zinc'] | 1,880,604 | [['D01.268.513.249'], ['E01.370.225.500.620.620.260.400', 'E01.370.225.750.600.620.260.400', 'E05.200.500.620.620.260.400', 'E05.200.750.600.620.260.400'], ['D01.268.556.289', 'D01.552.544.289'], ['L01.224.308'], ['E01.370.350.515.402', 'E05.595.402'], ['D01.268.185.850', 'D01.578.700'], ['E07.305.625'], ['G02.860'], [... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Improve care of kids with pediatric coordinator. | New guidelines from the American Academy of Pediatrics and the American College of Emergency Physicians recommend having physician and nurse pediatric coordinators to improve the care of children in the ED. The role of pediatric coordinator doesn't need to be a full-time or newly added position. Physician and nurse coo... | ['Child', 'Child, Hospitalized', 'Cooperative Behavior', 'Emergency Service, Hospital', 'Guidelines as Topic', 'Humans', 'Ohio', 'Pediatric Nursing', 'Quality Assurance, Health Care'] | 11,912,885 | [['M01.060.406'], ['M01.643.259'], ['F01.145.813.115'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'], ['H02.478.676.631', '... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Transmission network reconstruction for foot-and-mouth disease outbreaks incorporating farm-level covariates. | Transmission network modelling to infer 'who infected whom' in infectious disease outbreaks is a highly active area of research. Outbreaks of foot-and-mouth disease have been a key focus of transmission network models that integrate genomic and epidemiological data. The aim of this study was to extend Lau's systematic ... | ['Animals', 'Australia', 'Bayes Theorem', 'Cattle', 'Cattle Diseases', 'Disease Outbreaks', 'Farms', 'Foot-and-Mouth Disease', 'Foot-and-Mouth Disease Virus', 'Japan', 'Markov Chains', 'Monte Carlo Method', 'Phylogeny', 'Quarantine', 'Swine', 'Swine Diseases'] | 32,667,952 | [['B01.050'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['N06.850.290'], ['J01.040.372', 'J03.540.150'], ['C01.925.782.687.484', 'C22.380'], ['B04.820.578.750.070.250'], ['Z01.252.474.463', 'Z0... | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Effect of hypoxia and carbon monoxide on collagen synthesis in cultured porcine and bovine aortic endothelium. | The cell layers and medium of cultured porcine and bovine aortic endothelium have been examined to test the effects of 24 h treatment with two factors associated with cigarette smoke--hypoxia and carbon monoxide, on cell numbers, total protein including collagen/10(6) cells, collagen type profile and ultrastructure. Th... | ['Animals', 'Aorta', 'Carbon Monoxide', 'Cattle', 'Cell Count', 'Cells, Cultured', 'Collagen', 'Endoplasmic Reticulum', 'Endothelium', 'Oxygen', 'Protein Biosynthesis', 'Swine'] | 4,027,174 | [['B01.050'], ['A07.015.114.056'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.284.430.214.190.875.248'], ['A10.272.491'], ['D01.268.185.55... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
30 years of polytrauma care: An analysis of the change in strategies and results of 4849 cases treated at a single institution. | The quality and progress of treatment of 4849 multiple trauma patients treated at one institution was reviewed retrospectively. Three periods, 1975-1984 (decade I; n=1469) and 1985-1994 (decade II; n=1937) and 1995-2004 (decade III; n=1443) were compared. 65% of multiple trauma patients had cerebral injuries, 58% thora... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Clinical Protocols', 'Emergencies', 'Emergency Medical Services', 'Female', 'Fluid Therapy', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Multiple Organ Failure', 'Multiple Trauma', 'Resuscitation', 'Retrospective Studi... | 19,117,558 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['E02.183', 'N05.715.360.330.125'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['N02.421.297'], ['E02.319.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction. | PURPOSE: To determine whether elements of a standard nutritional screening assessment are independently prognostic of survival in patients with advanced cancer.PATIENTS AND METHODS: A prospective nested cohort of patients with metastatic cancer were accrued from different units of a Regional Palliative Care Program. Pa... | ['Aged', 'Female', 'Home Care Services', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Nutrition Assessment', 'Palliative Care', 'Predictive Value of Tests', 'Prognosis', 'Prospective Studies', 'Regression Analysis', 'Risk Assessment', 'Risk Factors', 'Survival Analysis'] | 20,805,456 | [['M01.060.116.100'], ['N02.421.143.524', 'N02.421.539.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['E05.318.308.585', 'N05.715.360.300.560', 'N06.850.505.557', 'N06.850.520.308.585'], ['E02.760.666', 'N02.421.585.666'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.8... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of Exercise Domain and Intensity on Sleep in Women and Men with Overweight and Obesity. | Inadequate sleep is associated with cardiometabolic risk and adiposity. Exercise has been suggested as an efficient strategy to improve sleep; however, the effects of different types of exercise on sleep in individuals with overweight and obesity are not well understood. We examined effects of active commuting and leis... | ['Accelerometry', 'Adiposity', 'Adult', 'Body Mass Index', 'Exercise', 'Female', 'Health Surveys', 'Humans', 'Leisure Activities', 'Male', 'Obesity', 'Overweight', 'Sleep', 'Sleep Deprivation'] | 31,089,425 | [['E05.003'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G11.427.410.698.277', 'I03.350'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants. | OBJECTIVE: Necrotizing enterocolitis (NEC) is a catastrophic abdominal complication threatening the life of premature infants, but adoption of prevention and early recognition practices differs as do NEC rates in Neonatal Intensive Care Units (NICUs). The purpose of this research was to validate and weight an evidence-... | ['Adult', 'Early Diagnosis', 'Enterocolitis, Necrotizing', 'Female', 'Guideline Adherence', 'Health Knowledge, Attitudes, Practice', 'Health Personnel', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Infant, Very Low Birth Weight', 'Intensive Care, Neonatal', 'Male', 'Middle Aged', 'Neonatal Nursing', 'Risk Factors... | 29,422,156 | [['M01.060.116'], ['E01.390'], ['C06.405.205.596.700', 'C06.405.469.363.700'], ['N04.761.337', 'N05.715.360.395'], ['F01.100.150.500', 'N05.300.150.410'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['M01.060.703.520.460.600'], ['E02.760.190... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Conserved residues amino-terminal of cytoplasmic tyrosines contribute to the SHP-1-mediated inhibitory function of killer cell Ig-like receptors. | The sequence I/VxYxxL, often referred to as an immunoreceptor tyrosine-based inhibition motif (ITIM), binds to the C-terminal Src homology 2 domain of the tyrosine phosphatase SHP-1. Conserved residues N-terminal of the tyrosine are not ordinarily found in other Src homology 2 domain binding motifs. The inhibitory form... | ['Amino Acid Sequence', 'Animals', 'Conserved Sequence', 'Cytoplasm', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Isoleucine', 'Killer Cells, Natural', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Peptide Fragments', 'Protein Tyrosine Phosphatase, Non-Receptor ... | 9,916,713 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.580'], ['A11.284.430.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['D12.125.070.577', 'D12.125.142.383'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.537', 'A15.382.490.555.567.537'], ['B01.050.15... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist. | The significance of serotonin in the pathogenesis of monocrotaline-induced pulmonary hypertension (MCT-PH) in rats, plasma serotonin concentrations, and the effect of a serotonin receptor antagonist administration in association with the number of proliferative cells were investigated. The thickness of the media of the... | ['Animals', 'Cell Division', 'Endothelium, Vascular', 'Hypertension, Pulmonary', 'Male', 'Monocrotaline', 'Proliferating Cell Nuclear Antigen', 'Pulmonary Alveoli', 'Pulmonary Artery', 'Rats', 'Rats, Sprague-Dawley', 'Serotonin', 'Serotonin Antagonists', 'Succinates'] | 10,773,132 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A07.015.700.500', 'A10.272.491.355'], ['C08.381.423', 'C14.907.489.556'], ['D03.132.716.500', 'D03.633.100.772.500'], ['D12.776.660.740', 'D23.050.290.750', 'D23.101.140.600'], ['A04.411.715'], ['A07.015.114.715'], ['B01.050.150.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SAH gene variants revisited in the European Project On Genes in Hypertension. | OBJECTIVE: Previous studies found significant association of hypertension and hypertension-related phenotypes with genetic variation in SAH (Spontaneously hypertensive rat-clone A-Hypertension-associated). We sought independent confirmation of these findings in the European Project On Genes in Hypertension.METHODS AND ... | ['Adult', 'Blood Glucose', 'Blood Pressure', 'Body Mass Index', 'Coenzyme A Ligases', 'Cohort Studies', 'European Continental Ancestry Group', 'Female', 'Haplotypes', 'Humans', 'Hypertension', 'Lipoproteins', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide'] | 18,192,838 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D08.811.464.267.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508.400'], ['G05.380.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Corrosion of stainless steel pipes in a hydrotherapy pool by a silver-copper disinfection system. | The silver-copper disinfection system has been shown to be effective for water purification. It emits silver ions that combine with bacteria, causing their death. While disinfecting the water, these silver ions exhibit adverse effects on the stainless steel pipes in hydrotherapy pools. In an oxidation-reduction reactio... | ['Burns', 'Copper', 'Corrosion', 'Equipment Design', 'Equipment Safety', 'Humans', 'Hydrotherapy', 'Microscopy, Electron, Scanning', 'Silver', 'Spectrometry, X-Ray Emission', 'Water Purification'] | 7,673,309 | [['C26.200'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G02.165'], ['E05.320'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.779.492', 'E02.831.535.492'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['E05.196.867.80... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fears and beliefs of people living with rheumatoid arthritis: a systematic literature review. | OBJECTIVE: To assess the main fears and beliefs of people with rheumatoid arthritis (RA) and their effect on treatment outcomes; METHODS: A systematic literature review was conducted in Pubmed/Medline; original articles published up to May 2017, reporting fears and/or beliefs of adult patients with RA were analyzed. Fe... | ['Adaptation, Psychological', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Fatigue', 'Fear', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Patient Compliance', 'Quality of Life', 'Treatment Outcome'] | 30,657,055 | [['F01.058'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['C23.888.369'], ['F01.470.361'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['F01.100.15... | ['Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Pulmonary vascular extraction of circulating norepinephrine in infants with bronchopulmonary dysplasia. | Although the pulmonary circulation in infants with advanced bronchopulmonary dysplasia (BPD) is characterized by abnormal structure and vasoreactivity, metabolic lung functions have not been studied in these infants. To test the hypothesis that patients with severe BPD may have abnormal metabolic lung function, we asse... | ['Bronchopulmonary Dysplasia', 'Cardiac Catheterization', 'Epinephrine', 'Heart Defects, Congenital', 'Hemodynamics', 'Humans', 'Infant', 'Infant, Newborn', 'Lung', 'Norepinephrine', 'Pulmonary Circulation'] | 3,696,807 | [['C08.381.520.750.500', 'C16.614.521.125'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['G09.330.380'], ['B01.050.150.900.649.3... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vitamin D is crucial for maternal care and offspring social behaviour in rats. | Early life vitamin D plays a prominent role in neurodevelopment and subsequent brain function, including schizophrenic-like outcomes and increasing evidence for an association with autism spectrum disorder (ASD). Here, we investigate how early life vitamin D deficiency during rat pregnancy and lactation alters maternal... | ['Animals', 'Behavior, Animal', 'Female', 'Lactation', 'Male', 'Maternal Behavior', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Sprague-Dawley', 'Social Behavior', 'Vitamin D', 'Vitamin D Deficiency'] | 29,559,544 | [['B01.050'], ['F01.145.113'], ['G08.686.523', 'G08.686.702.500'], ['F01.829.263.370.215'], ['G08.686.784.769'], ['C13.703.824.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['F01.145.813'], ['D04.210.500.812.768'], ['C18.654.521.500.133.770']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. | A series of potent thienotriazolopyrimidinone-based PDE1 inhibitors was discovered. X-ray crystal structures of example compounds from this series in complex with the catalytic domain of PDE1B and PDE10A were determined, allowing optimization of PDE1B potency and PDE selectivity. Reduction of hERG affinity led to great... | ['Crystallography, X-Ray', 'Drug Discovery', 'Memory', 'Phosphodiesterase Inhibitors'] | 28,406,621 | [['E05.196.309.742.225'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['F02.463.425.540'], ['D27.505.519.389.735']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Phospholipid depletion and re-activation of guinea-pig liver microsomal enzyme. | More than 80% of the phospholipid component of guinea-pig liver microsomal membranes (prepared with 154mM-KCl) was removed by treatment with phospholipase A followed by extraction of the lysophosphatides and fatty acids produced with albumin. Delipidation strongly inactivated the highly active UDP-glucuronyltransferase... | ['Animals', 'Chromatography, Gel', 'Enzyme Reactivators', 'Glucuronosyltransferase', 'Guinea Pigs', 'Lysophosphatidylcholines', 'Male', 'Microsomes, Liver', 'Phosphatidylcholines', 'Phospholipases', 'Phospholipids'] | 405,972 | [['B01.050'], ['E05.196.181.400.250'], ['D27.505.519.405'], ['D08.811.913.400.450.480'], ['B01.050.150.900.649.313.992.550'], ['D10.570.755.375.760.550.550'], ['A11.284.835.540.541'], ['D10.570.755.375.760.400.800'], ['D08.811.277.352.100.680', 'D08.811.277.352.640.700'], ['D10.570.755']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The evaluation of viral load in patients with hemorrhagic fever with renal syndrome (HFRS) by real-time polymerase chain reaction]. | The system for real-time polymerase chain reaction was developed for detection of Puumala virus RNAand quantitative analysis of viral RNAload in clinical samples. Dynamics of viral load in blood samples from 12 patients with HFRS (from day 4 to day 17 of the disease) was studied. At day 4 viral RNA load varied from 4 x... | ['DNA Primers', 'Hemorrhagic Fever with Renal Syndrome', 'Humans', 'Polymerase Chain Reaction', 'Puumala virus', 'RNA, Viral', 'Russia', 'Sensitivity and Specificity', 'Time Factors', 'Viral Load'] | 17,672,134 | [['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['C01.925.782.147.420.400', 'C01.925.782.417.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500'], ['B04.820.480.750.440.600'], ['D13.444.735.828'], ['Z01.252.122.500', 'Z01.542.248.775'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A role for local calcium gradients upon hypoxic injury in human umbilical vein endothelial cells (HUVEC). | Upon hypoxic injury, bleb formation is an early event of cell damage observed in a variety of cell types. Although a rise in cytosolic free Ca2+ ([Ca2+]i) has been considered to be involved in this process, the exact relationship between these phenomena remains ill-defined. In order to examine the relationship between ... | ['Analog-Digital Conversion', 'Calcium', 'Cell Hypoxia', 'Cell Survival', 'Cells, Cultured', 'Endothelium, Vascular', 'Humans', 'Intracellular Membranes', 'Membrane Potentials', 'Microscopy, Confocal', 'Mitochondria', 'Rhodamine 123', 'Umbilical Veins'] | 9,793,688 | [['L01.224.230.260.280.080'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['A11.251'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.149.450', 'A11.284.835.514'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.5... | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The time scale of the quaternary structural changes in hemoglobin revealed using the transient grating technique. | The quaternary structural transition between the R and T states of human hemoglobin was investigated using the transient grating technique. The results presented herein reveal that the quaternary structural change accompanied by the R-T transition occurs within a few microseconds. | ['Hemoglobins', 'Humans', 'Kinetics', 'Molecular Structure', 'Spectrum Analysis', 'Time Factors'] | 26,272,458 | [['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['G02.111.570', 'G02.466'], ['E05.196.867'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Supraspinal cell populations projecting to the cerebellar cortex in the turtle (Pseudemys scripta elegans). | Neuronal cell populations giving rise to cerebellar projections in the turtle, Pseudemys scripta elegans, were analysed following injections of horseradish peroxidase into the cerebellar cortex. The most prominent retrograde cell labeling occurred bilaterally within the caudal rhombencephalon and especially in the vent... | ['Afferent Pathways', 'Animals', 'Brain', 'Brain Stem', 'Cerebellar Cortex', 'Dominance, Cerebral', 'Hypothalamus', 'Mesencephalon', 'Neurons', 'Red Nucleus', 'Reticular Formation', 'Spinal Cord', 'Turtles'] | 6,861,928 | [['A08.612.220'], ['B01.050'], ['A08.186.211'], ['A08.186.211.132'], ['A08.186.211.132.810.428.200.212'], ['F02.830.297', 'G11.561.225'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['A08.186.211.132.659'], ['A08.675', 'A11.671'], ['A08.186.211.132.659.413.875.642'], ['A08.186.211.132.772'], ['A08.186.854'], ['... | ['Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Non-granular proteolytic enzymes of rat interleukin-2-activated natural killer cells. III. Enhancement of A-NKP 1, 2, and 3 proteolytic activities (cleaving after Arg, Phe and Pro) in response to interleukin-2. | Rat IL-2-activated natural killer (A-NK) cells contain a number of cytosolic proteases (A-NKP 1-3), two of which (A-NKP 2 and A-NKP 3) have been implicated in cytolytic function. The 3.2.3 monoclonal antibody directed against the NKRP-1 signal transduction molecule, a selective marker of rat NK cells, was used to selec... | ['Animals', 'Cytoplasmic Granules', 'Cytosol', 'Cytotoxicity, Immunologic', 'Endopeptidases', 'Interleukin-2', 'Killer Cells, Natural', 'Lymphocyte Activation', 'Male', 'Rats', 'Rats, Inbred F344'] | 8,933,822 | [['B01.050'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G12.287'], ['D08.811.277.656.300'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', '... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade. | The interaction between endothelial cells and extracellular matrix proteins plays an important role in (hem)angiogenesis. Integrins are able to mediate the outgrowth of newly formed blood vessels. In contrast, the role of integrins in lymphangiogenesis, ie, the outgrowth of new from pre-existing lymphatic vessels, has ... | ['Animals', 'Cornea', 'Endothelium, Corneal', 'Endothelium, Vascular', 'In Vitro Techniques', 'Inflammation', 'Integrin alpha5', 'Integrin alphaV', 'Lymphangiogenesis', 'Lymphatic Vessels', 'Mice', 'Mice, Inbred BALB C', 'Vascular Endothelial Growth Factor Receptor-2', 'Vascular Endothelial Growth Factor Receptor-3'] | 17,591,980 | [['B01.050'], ['A09.371.060.217'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.481'], ['C23.550.470'], ['D12.776.543.750.705.408.100.500'], ['D12.776.543.750.705.408.100.900'], ['G07.345.500.325.377.437'], ['A15.382.520.301'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Postnephrectomy pseudoaneurysm with arteriovenous fistula. | Sonography detected a paraaortic pulsatile tubular mass in a patient 10 years after "stump" nephrectomy, which was subsequently confirmed as a renal artery-renal vein fistula by computed tomography, angiography, and laparotomy. | ['Adult', 'Arteriovenous Fistula', 'Humans', 'Male', 'Nephrectomy', 'Renal Artery', 'Renal Veins', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 3,293,298 | [['M01.060.116'], ['C14.240.850.750.147', 'C14.240.850.984.750', 'C14.907.150.125', 'C14.907.933.555', 'C16.131.240.850.750.125', 'C23.300.575.950.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.774.435'], ['A07.015.114.745'], ['A07.015.908.752'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810',... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
P300 during response inhibition is associated with ad-lib alcohol consumption in social drinkers. | Reduced amplitude of the cortical P300 event-related potential (ERP) component during response inhibition is associated with vulnerability to alcohol use disorders. In the current study, we investigated the effect of an experimental manipulation of response conflict on the amplitude of the P300 component during respons... | ['Adolescent', 'Alcohol Drinking', 'Conflict, Psychological', 'Drug-Seeking Behavior', 'Electroencephalography', 'Ethanol', 'Event-Related Potentials, P300', 'Female', 'Humans', 'Inhibition, Psychological', 'Male', 'Young Adult'] | 23,598,400 | [['M01.060.057'], ['F01.145.317.269'], ['F01.658.209'], ['F01.145.342'], ['E01.370.376.300', 'E01.370.405.245'], ['D02.033.375'], ['G07.265.216.500.350', 'G11.561.200.500.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Interstitial pneumonia associated with collagen vascular diseases: histological findings, and cells in bronchoalveolar lavage fluid]. | Collagen vascular diseases are systemic inflammatory disorders, and autoimmune abnormalities play an important role in their pathogenesis. The lungs are often involved and the manifestations can be quite heterogenous. Cases of interstitial pneumonia associated with collagen vascular disease must be distinguished from i... | ['Adult', 'Bronchoalveolar Lavage Fluid', 'Cell Count', 'Collagen Diseases', 'Female', 'Humans', 'Lung Diseases, Interstitial', 'Male', 'Middle Aged'] | 8,752,516 | [['M01.060.116'], ['E05.927.100.500'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['C17.300.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.483'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts. | Graves' disease (GD) and Hashimoto's thyroiditis (HT) are autoimmune processes often associated with hyperthyroidism and hypothyroidism, respectively. Despite their diverging clinical presentations, immune activation drives both diseases and results in connective tissue accumulation of the nonsulfated glycosaminoglycan... | ['Cell Count', 'Cells, Cultured', 'DNA-Binding Proteins', 'Epithelial Cells', 'Fetal Blood', 'Fibroblasts', 'Glucuronosyltransferase', 'Graves Disease', 'Hashimoto Disease', 'Humans', 'Hyaluronan Synthases', 'Hyaluronic Acid', 'Intercellular Signaling Peptides and Proteins', 'Interleukin-1beta', 'RNA, Messenger', 'Thyr... | 17,068,136 | [['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.251'], ['D12.776.260'], ['A11.436'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['A11.329.228'], ['D08.811.913.400.450.480'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['C19.874.871.102.500'], ['B01.050.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies. | Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with 2- or 4-[18F]fluoro... | ['Animals', 'Brain', 'Fluorine Radioisotopes', 'Isotope Labeling', 'Nortropanes', 'Rats', 'Receptors, Dopamine D2', 'Tomography, Emission-Computed'] | 1,330,979 | [['B01.050'], ['A08.186.211'], ['D01.496.749.340'], ['E05.522'], ['D02.145.074.722.744', 'D03.605.084.500.722.744', 'D03.605.869.744'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750.670.300.400.500', 'D12.776.543.750.695.150.400.500', 'D12.776.543.750.720.330.400.500'], ['E01.370.350.350.800', 'E01.370... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Testing the relationship between self-agency and enactment of health behaviors. | A theoretical review provides a rationale for examining self-agency as a developmental foundation underlying processes of self-regulated change and a potential moderator of intervention effectiveness among participants in a nurse home-visitation program. Self-agency is defined as the conceptual understanding of self as... | ['Adolescent', 'Adult', 'Community Health Nursing', 'Female', 'Health Behavior', 'Health Promotion', 'Humans', 'Likelihood Functions', 'Maternal Behavior', 'Mothers', 'Poverty', 'Pregnancy', 'Psychological Theory', 'Self Efficacy', 'Tennessee'] | 12,532,364 | [['M01.060.057'], ['M01.060.116'], ['H02.478.676.150', 'N02.421.143.150'], ['F01.145.488'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.83... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[The provision of hearing aids to young children with congenital hearing impairment]. | Early screening for hearing impairment in children is generally advised to prevent sensory deprivation and speech, language and learning problems. In the present study, the age at which 176 probably congenitally hearing impaired infants were referred to the Audiological Centre in Nijmegen between 1983 and 1990 was exam... | ['Age Factors', 'Child, Preschool', 'Correction of Hearing Impairment', 'Hearing Aids', 'Hearing Disorders', 'Humans', 'Language Development', 'Retrospective Studies'] | 1,641,048 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406.448'], ['E02.760.169.063.500.200', 'E02.831.200', 'H02.403.680.600.500', 'N02.421.784.377'], ['E07.305.906.500', 'E07.814.458'], ['C09.218.458', 'C10.597.751.418', 'C23.888.592.763.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.525.200.310'], ['E05.3... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Signal sequence and DNA-mediated expression of human lysosomal alpha-galactosidase A. | Twelve complementary DNA clones for human lysosomal alpha-galactosidase A were isolated from an Okayama-Berg library constructed from SV40-transformed human fibroblasts. The identity of these clones was confirmed by complete colinearity of the nucleotide-deduced amino acid sequence with that determined by direct chemic... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'Chromosome Mapping', 'Cloning, Molecular', 'DNA', 'Galactosidases', 'Genetic Code', 'Humans', 'Hybrid Cells', 'Lysosomes', 'Mice', 'Nucleic Acid Hybridization', 'Protein Sorting Signals', 'alpha-Galactosidase'] | 3,036,505 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['E05.393.183'], ['E05.393.220'], ['D13.444.308'], ['D08.811.277.450.410'], ['G05.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.600'], ['A11.284.430.214.190.875.1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Binding of discoidin domain receptor 2 to collagen I: an atomic force microscopy investigation. | Collagens have recently been identified as ligands for discoidin domain receptors (DDR1 and DDR2), generating an interest in studying the properties of binding of DDR to its ligand. We are interested in the interaction of DDR2 with collagen I because of its potential role in liver fibrosis. Our in vitro binding assay u... | ['Animals', 'Binding Sites', 'Collagen Type I', 'Discoidin Domain Receptors', 'Humans', 'Immunoglobulin Fc Fragments', 'Immunoglobulin G', 'Ligands', 'Mice', 'Microscopy, Atomic Force', 'Protein Binding', 'Receptor Protein-Tyrosine Kinases', 'Receptors, Mitogen', 'Recombinant Fusion Proteins'] | 12,220,173 | [['B01.050'], ['G02.111.570.120'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D08.811.913.696.620.682.725.400.005', 'D12.776.543.750.630.005', 'D12.776.543.750.685.050', 'D12.776.543.750.705.880.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541.500.697', 'D12.776.124.486.485.538.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Felis catus | Several studies based on histopathology or molecular investigations suggest a causal relation between Felis catus papillomavirus (FcaPV-2) infection and bowenoid in situ carcinoma (BISC) in cats. Nevertheless, data on distribution of viral DNA for different F. catus papillomavirus types (FcaPV-1, 2, 3, 4, 5) in precanc... | ['Animals', 'Carcinoma in Situ', 'Cat Diseases', 'Cats', 'Chromogenic Compounds', 'DNA Probes', 'DNA, Viral', 'Feasibility Studies', 'In Situ Hybridization', 'Papillomaviridae', 'Papillomavirus Infections', 'Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Skin'] | 31,266,406 | [['B01.050'], ['C04.557.470.200.240'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['D27.720.233.174', 'D27.720.470.410.200'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.568'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Simultaneous lateral bone augmentation and implant placement using a particulated synthetic bone substitute around chronic peri-implant dehiscence defects in dogs. | AIM: To determine the histological outcomes when using a highly porous synthetic bone substitute and a cross-linked collagen membrane for lateral bone augmentation of peri-implant dehiscence defects.METHODS: In eight dogs, three treatment groups were randomly allocated at each peri-implant dehiscence defect (mean heigh... | ['Alveolar Ridge Augmentation', 'Animals', 'Bone Substitutes', 'Dental Implantation, Endosseous', 'Dogs', 'Female', 'Guided Tissue Regeneration, Periodontal', 'Male', 'Surgical Wound Dehiscence', 'Tooth Extraction'] | 28,815,664 | [['E04.545.550.100', 'E06.645.550.100'], ['B01.050'], ['D25.130.325', 'J01.637.051.130.325'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['B01.050.150.900.649.313.750.250.216.200'], ['E04.680.300.500', 'E06.645.410', 'E06.721.485'], ['C23.550.767.887'], ['E04.545.700', 'E06.64... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparison of the Trends in Risk Factors and Management of Severe Postpartum Hemorrhage Years 2000-2004 Versus 2005-2008. | OBJECTIVE: To compare trends in the etiology and management of severe postpartum hemorrhage (PPH) during 2 time periods: 2000-2004 (Period 1) versus 2005-2008 (Period 2).STUDY DESIGN: Medical records with a diagnosis of PPH were identified by ICD-9 codes for immediate, third-stage, delayed, and secondary. PPH and post-... | ['Female', 'Humans', 'Misoprostol', 'Oxytocics', 'Postpartum Hemorrhage', 'Postpartum Period', 'Pregnancy', 'Risk Factors', 'Uterine Inertia'] | 30,408,376 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.251.355.255.550.775.450.500', 'D23.469.050.175.725.775.450.500', 'D23.469.700.660.500'], ['D27.505.696.875.737', 'D27.505.954.705.737'], ['C13.703.420.725', 'C13.703.844.700', 'C23.550.414.993.850'], ['G08.686.702'], ['G08.686.784.769'], ['E05.318.740.600.800.725'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Wide variation in anal sphincter muscles in cases of high- and intermediate-type male anorectal malformation. | PURPOSE: The distribution of sphincter muscle complex in anorectal malformation (ARM) needs to be investigated on a case-by-case basis. This study was undertaken to demonstrate the differences in the anal sphincter muscles between patients with the same type of ARM. Computed tomography (CT) data from cases of high- and... | ['Anal Canal', 'Anorectal Malformations', 'Anus, Imperforate', 'Humans', 'Male', 'Muscle, Smooth'] | 23,292,537 | [['A03.556.124.526.070', 'A03.556.249.249.070'], ['C06.198.025', 'C16.131.314.047'], ['C06.198.050', 'C16.131.314.094'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.570', 'A10.690.467']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fate of clinically insignificant residual fragments after extracorporeal shock wave lithotripsy with EDAP LT-01 lithotripter. | The stone-free rate of 248 cases of clinically insignificant residual fragments (CIRF) was 32.7% by 1 month, 73.0% by 3 months, and 92.7% by 6 months of follow-up. The stone-free rate decreased but not remarkably in accordance with the increment of the caliceal dilatation (92.9%, 94.9%, 85.7%, and 83.3% for no, mild, m... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Equipment and Supplies', 'Follow-Up Studies', 'Humans', 'Kidney Calculi', 'Lithotripsy', 'Middle Aged', 'Treatment Outcome'] | 8,124,335 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['E07'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.600.500', 'C12.777.967.249.500', 'C12.777.967.500.503', 'C13.351.968.419.600.500', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Removal of Pb(II) and Cd(II) ions from aqueous solution by thiosemicarbazide modified chitosan. | The removal of Pb(II) and Cd(II) ions from aqueous solution by thiosemicarbazide modified chitosan (TCS) was studied in this article. The synthesized TCS was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), element analysis, N2 adsorption-desorption, scanning electron microscopy... | ['Adsorption', 'Cadmium', 'Chitosan', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lead', 'Semicarbazides', 'Solutions', 'Temperature', 'Water', 'Water Pollutants, Chemical'] | 26,879,912 | [['G01.030', 'G02.020'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['D05.750.078.139.500', 'D09.698.211.500'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D01.268.556.435', 'D01.552.544.435'], ['D02.845'], ['D26.776'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.45... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Regression analysis of factorially designed trials--a logical approach to protein crystallization. | The specific composition of the mother liquor that induces the formation of protein crystal is usually quoted as the 'best condition' for crystallization. However, very little is described about how these conditions were determined. These missing and non-reported details would certainly lead to a better understanding o... | ['Calmodulin', 'Crystallization', 'Models, Statistical', 'Muramidase', 'Myelin Proteins', 'Proteins', 'Regression Analysis'] | 7,669,807 | [['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['E05.196.300', 'G02.171'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['D08.811.277.450.642'], ['D12.776.543.620', 'D12.776.631.580'], ['D12.776'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Oral desmopressin lyophilisate (MELT) for monosymptomatic enuresis: structured versus abrupt withdrawal. | OBJECTIVE: To investigate whether a structured withdrawal program from a sublingual formulation of fast-melting oral desmopressin lyophilisate (MELT) is superior to a sudden withdrawal from this formulation in the treatment of monosymptomatic nocturnal enuresis.MATERIALS AND METHODS: One hundred and three children pres... | ['Administration, Sublingual', 'Adolescent', 'Antidiuretic Agents', 'Child', 'Child, Preschool', 'Deamino Arginine Vasopressin', 'Enuresis', 'Female', 'Humans', 'Male', 'Recurrence'] | 23,791,016 | [['E02.319.267.100.878'], ['M01.060.057'], ['D27.505.696.560.249'], ['M01.060.406'], ['M01.060.406.448'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456.925.100.250', 'D12.644.548.691.692.781.100.250', 'D12.776.631.650.937.100.250'], ['C12.777.934.284', 'C13.351.968.934.252', 'F01.145.126.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice. | BACKGROUND: Atherosclerosis and vascular calcification are major contributors to cardiovascular morbidity and mortality among chronic kidney disease patients. The mevalonate pathway may play a role in this vascular pathology. Farnesyltransferase inhibitors such as R115777 block one branch of mevalonate pathway. We stud... | ['Animals', 'Aorta', 'Apolipoproteins E', 'Apoptosis', 'Atherosclerosis', 'Blood Proteins', 'Body Weight', 'Collagen Type I', 'Enzyme Inhibitors', 'Farnesyltranstransferase', 'Female', 'Kidney Failure, Chronic', 'Liver', 'Macrophages', 'Mevalonic Acid', 'Mice', 'Mice, Knockout', 'Muscle, Smooth, Vascular', 'Prenylation... | 23,672,878 | [['B01.050'], ['A07.015.114.056'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['G04.146.954.035'], ['C14.907.137.126.307'], ['D12.776.124'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D05.750.078.280.300.100', 'D12.776.8... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Relation of time to treatment and mortality in patients with acute myocardial infarction undergoing primary coronary angioplasty. | The benefit of thrombolysis is dependent on time to treatment, but there is lack of evidence of this relation in patients undergoing primary percutaneous transluminal coronary angioplasty (PTCA). The hypothesis that the relation of time to treatment to mortality is dependent on patient risk was tested in a series of 1,... | ['Aged', 'Analysis of Variance', 'Angioplasty, Balloon, Coronary', 'Coronary Angiography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Outcome Assessment, Health Care', 'Patient Transfer', 'Prospective Studies', 'Risk Factors', 'Stents', 'Survival Analysis', 'Time Factors'] | 12,031,722 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.350.130.625', 'E01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Alcohol withdrawal syndromes - prediction from detailed medical and drinking histories. | The predictability of the withdrawal syndrome on the basis of the drinking history immediately prior to detoxification was investigated in 43 patients admitted to an inpatient Alcoholism Service; a pilot study consisted of 17 patients and a subsequent definitive study of 26. After obtaining informed consent, blood alco... | ['Adult', 'Aged', 'Alcohol Drinking', 'Alcohol Withdrawal Delirium', 'Alcoholism', 'Diazepam', 'Female', 'Flurazepam', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Psychoses, Alcoholic'] | 6,861,616 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['C10.720.112.200', 'C25.723.705.150.200', 'C25.775.100.087.193.200', 'C25.775.835.250', 'F03.900.100.100', 'F03.900.825.500'], ['C25.775.100.250', 'F03.900.100.350'], ['D03.633.100.079.080.070.216'], ['D03.633.100.079.080.070.348'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial. | UNLABELLED: This study aimed to determine the effect of fish oil on bone mineral density (BMD). There were no differences in the 2-year BMD measures between high and low dose groups after adjusting for baseline BMD. This randomized controlled trial did not demonstrate any efficacy of omega-3 fatty acids on bone loss in... | ['Absorptiometry, Photon', 'Adult', 'Aged', 'Aged, 80 and over', 'Bone Density', 'Dietary Supplements', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Fatty Acids, Omega-3', 'Female', 'Femur Neck', 'Humans', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Osteoarthritis, Knee'] | 26,694,596 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.100'], ['G07.203.300.456', 'J02.500.456'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D10.212.302.380.410', 'D10.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation. | Caseinolytic protease P (ClpP) has emerged as a promising new target for antibacterial development. While ClpPs from single isoform expressing bacteria have been studied in detail, the function and regulation of systems with more than one ClpP homologue are still poorly understood. Herein, we present fundamental studie... | ['Clostridioides difficile', 'Depsipeptides', 'Endopeptidase Clp', 'Gene Expression Regulation, Bacterial', 'Isoenzymes', 'Proteolysis', 'Proteomics', 'Sequence Homology, Amino Acid', 'Virulence'] | 30,411,608 | [['B03.353.625.657.500'], ['D04.345.566.297', 'D12.644.641.297'], ['D08.811.277.040.013.500.032.099.500', 'D08.811.277.040.025.024.032.099.500', 'D08.811.277.656.149.099.500', 'D08.811.277.656.300.065.500', 'D12.776.157.025.750.032.099.500', 'D12.776.575.374', 'D12.776.765.199.249'], ['G05.308.300'], ['D08.811.348', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Physiological relationships and circadian periodicities in rodent trypanosomes. | Trypanosome circadian rhythms in rats infected with Trypanosoma lewisi and mice infected with T. duttoni (equals T. musculi) were observed. Peak numbers of trypanosomes were recorded at nightfall and fewest organisms seen at daybreak. Reversal of the photoperiod resulted in a comparable reversal of the trypanosome para... | ['Animals', 'Blood', 'Circadian Rhythm', 'Darkness', 'Leukocyte Count', 'Light', 'Lymph Nodes', 'Mice', 'Periodicity', 'Rats', 'Trypanosomiasis'] | 982,519 | [['B01.050'], ['A12.207.152', 'A15.145'], ['G07.180.562.190'], ['G01.590.540.233'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.595'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.75... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of organometals on cellular signaling. II. Inhibition of reincorporation of free arachidonic acid and influence on paf-acether synthesis by triethyllead. | Organometal compounds affect many enzymes, especially those containing SH-groups as acyl- and acetyltransferases involved in lysophospholipid reacylation. In HL-60 cells, organotin and -lead compounds stimulate phospholipase A2 activity, contributing thus to increase the level of lysophospholipids. In the present study... | ['Acetyl-CoA C-Acetyltransferase', 'Arachidonic Acid', 'Cell Communication', 'Cell Differentiation', 'Humans', 'Lead', 'Lysophospholipids', 'Organometallic Compounds', 'Platelet Activating Factor', 'Tumor Cells, Cultured'] | 7,843,129 | [['D08.811.913.050.134.025'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G04.085'], ['G04.152'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['D10.570.755.375.760.550'], ['D02.691'], ['D02.033.100.291.211.500', 'D02.092.063.291.211.500', 'D02.092.877.883.333.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cellular and subcellular localization of heme oxygenase-2 in monkey retina. | Carbon monoxide (CO), an activator of soluble guanylate cyclase (SGC) and generated enzymatically by heme oxygenases (HO), is considered to function as an intra- and intercellular neuromodulator or neurotransmitter in the central and peripheral nervous systems. HO-2 is the constitutive isoform of HO and is more prevale... | ['Animals', 'Cyclic GMP', 'Heme Oxygenase (Decyclizing)', 'Immunohistochemistry', 'Kidney', 'Macaca', 'Rats', 'Retina'] | 15,520,526 | [['B01.050'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D08.811.682.690.708.410'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Wavelet de-noising method with adaptive threshold selection for photoacoustic tomography. | Photoacoustic (PA) tomography enables imaging of optical absorption property in deep scattering tissue by listening to the PA wave. However, it is an open challenge that the conversion efficiency from light to sound based on PA effect is extremely low. The consequence is the poor signal-to-noise ratio (SNR) of PA signa... | ['Algorithms', 'Signal-To-Noise Ratio', 'Tomography, X-Ray Computed'] | 30,441,419 | [['G17.035', 'L01.224.050'], ['E05.318.370.800.875', 'E05.318.740.872.875', 'G17.800.500', 'N05.715.360.325.700.840', 'N05.715.360.750.725.750', 'N06.850.520.445.800.875', 'N06.850.520.830.872.750'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.35... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue. | Aggregation of the amyloid beta-peptide (Abeta) into insoluble fibrils is a key pathological event in Alzheimer's Disease (AD). There is now compelling evidence that metal binding to Abeta is involved in AD pathogenesis. The amino acid region 1-16 is widely considered as the metal binding domain of Abeta. In this work,... | ['Amino Acid Sequence', 'Amyloid beta-Peptides', 'Copper', 'Molecular Sequence Data', 'Mutation', 'Peptide Fragments', 'Polyethylene Glycols', 'Potentiometry', 'Spectrum Analysis', 'Zinc'] | 19,780,525 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['L01.453.245.667'], ['G05.365.590'], ['D12.644.541'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['E05.196.922.75... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
89 | The hepatocyte growth factor (HGF) binding antibody rilotumumab (AMG102) was modified for use as a 89Zr-based immuno-PET imaging agent to noninvasively determine the local levels of HGF protein in tumors. Because recent clinical trials of HGF-targeting therapies have been largely unsuccessful in several different cance... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Cell Line, Tumor', 'Cell Transformation, Neoplastic', 'Deferoxamine', 'Female', 'Gene Expression Regulation, Neoplastic', 'Hepatocyte Growth Factor', 'Humans', 'Immunoconjugates', 'Mice', 'Patient Selection', 'Positron-Emission Tomography', 'Ra... | 28,280,216 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D02.092.570.394.26... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Troms? Study: identification of and a controlled intervention on a population of early-stage risk drinkers. | BACKGROUND: In a health survey of more than 21,000 men and women ages 12-62 years, measurement of gamma-glutamyltransferase (GGT) and answers on five questions on alcohol consumption were used as a basis for selecting an intervention population of early-stage risk drinkers. Altogether 290 men and 48 women met the crite... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcoholism', 'Female', 'Humans', 'Male', 'Middle Aged', 'Norway', 'Risk Factors', 'gamma-Glutamyltransferase'] | 1,678,518 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.816.374'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cap1p attenuates the apoptosis of Candida albicans. | Candida albicans is the most common opportunistic fungal pathogen and its apoptosis is inducible by environmental stress. Based on our previous finding that transcription factor Cap1p was involved in baicalein-induced apoptosis, the present study aimed to further clarify the role of Cap1p in apoptosis by observing the ... | ['Amphotericin B', 'Apoptosis', 'Basic-Leucine Zipper Transcription Factors', 'Candida albicans', 'Cell Cycle Proteins', 'Fungal Proteins', 'Gene Deletion', 'Gene Expression Regulation, Fungal', 'Genes, Fungal', 'Glutathione', 'Glutathione Reductase', 'Transcription Factors'] | 23,517,286 | [['D02.540.576.500.500'], ['G04.146.954.035'], ['D12.776.260.108', 'D12.776.930.127'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['D12.776.167'], ['D12.776.354'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.330'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The endoplasmic reticulum is a target organelle for trivalent dimethylarsinic acid (DMAIII)-induced cytotoxicity. | The purpose of present study was to characterize the endoplasmic reticulum stress and generation of ROS in rat liver RLC-16 cells by exposing to trivalent dimethylarsinous acid (DMAIII) and compared with that of trivalent arsenite (iAsIII) and monomethylarsonous acid (MMAIII). Protein kinase-like endoplasmic reticulum ... | ['Activating Transcription Factor 4', 'Animals', 'Arsenites', 'Cacodylic Acid', 'Cell Line', 'Endoplasmic Reticulum', 'Endoplasmic Reticulum Stress', 'Heat-Shock Proteins', 'Liver', 'Organometallic Compounds', 'Phosphorylation', 'Protein Folding', 'RNA, Messenger', 'Rats', 'Reactive Oxygen Species', 'Transcription Fact... | 22,425,709 | [['D12.776.260.108.061.937', 'D12.776.930.127.061.937'], ['B01.050'], ['D01.075.050', 'D01.248.497.158.055'], ['D02.129.100'], ['A11.251.210'], ['A11.284.430.214.190.875.248'], ['G04.434'], ['D12.776.580.216'], ['A03.620'], ['D02.691'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G01.154.651', 'G02.111.688'], ['D13.44... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanical nociception measurement in mice and rats with automated Von Frey equipment. | Von Frey hairs are important tools for the study of mechanisms of cutaneous stimulation-induced sensory input. Mechanical force is exerted via application of a particular hair to the cutaneous receptive field until buckling of the hair occurs. The most commonly used Von Frey filaments are productive in evaluating behav... | ['Animals', 'Disease Models, Animal', 'Hyperalgesia', 'Mice', 'Nociception', 'Pain Measurement', 'Pain Threshold', 'Physical Stimulation', 'Rats'] | 25,293,329 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['F02.463.593.504.500'], ['E01.370.600.550.324'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['E05.723'], ['B01.050.150.900.649.313.99... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Participation of prostaglandins E2 and F2 alpha in the action of fibrinopeptides A and B on the central dopaminergic system. | The participation of prostaglandins (PGs) E2 and F2 alpha administered icv in the action of fibrinopeptides A and B (FAB) on the central dopamine neurons was investigated. PGE2 and PGF2 alpha (0.5 microgram) attenuated the intensity of apomorphine (APO)-induced stereotypy and completely abolished the stimulatory action... | ['Amphetamine', 'Animals', 'Apomorphine', 'Brain Chemistry', 'Dinoprost', 'Dinoprostone', 'Fibrinogen', 'Fibrinopeptide A', 'Fibrinopeptide B', 'Haloperidol', 'Male', 'Prostaglandins E', 'Prostaglandins F', 'Rats', 'Rats, Inbred Strains', 'Receptors, Dopamine', 'Stereotyped Behavior'] | 3,463,941 | [['D02.092.471.683.152.110'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['G02.111.150', 'G03.185'], ['D10.251.355.255.550.400.200', 'D23.469.050.175.725.400.200'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D12.776.124.050.250', 'D12.776.124.125.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A risk and maintenance model for bulimia nervosa: From impulsive action to compulsive behavior. | This article offers a new model for bulimia nervosa (BN) that explains both the initial impulsive nature of binge eating and purging, as well as the compulsive quality of the fully developed disorder. The model is based on a review of advances in research on BN and advances in relevant basic psychological science. It i... | ['Bulimia Nervosa', 'Humans', 'Impulsive Behavior', 'Models, Psychological', 'Self-Control'] | 25,961,467 | [['F03.400.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['E05.599.695'], ['F01.145.813.595']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression. | Computational analyses have been used to study the biomechanical microenvironment of the chondrocyte that cannot be assessed by in vitro experimental studies; yet all computational studies thus far have focused on the effect of zonal location (superficial, middle, and deep) on the mechanical microenvironment of chondro... | ['Biomechanical Phenomena', 'Cartilage, Articular', 'Chondrocytes', 'Compressive Strength', 'Extracellular Matrix', 'Humans', 'Models, Biological', 'Permeability', 'Shear Strength', 'Stress, Mechanical'] | 24,882,738 | [['G01.154.090', 'G01.374.089'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.329.171'], ['G01.374.180'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G02.723'], ['G01.374.820'], ['G01.374.835']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. | Innate-like natural killer T (NKT) cells critically enhance cell and humoral immunity against infections through recognition of conserved microbial lipid antigens presented by CD1d-expressing antigen-presenting cells, and provision of CD40L and cytokine signals. Whereas NKT cells efficiently licensed dendritic cells to... | ['Animals', 'Antibodies', 'B-Lymphocytes', 'Cell Communication', 'Cell Differentiation', 'Flow Cytometry', 'Immunologic Memory', 'Mice', 'Mice, Inbred C57BL', 'Nanoparticles', 'Natural Killer T-Cells', 'Pneumococcal Infections', 'Polysaccharides, Bacterial', 'Statistics, Nonparametric'] | 24,043,771 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.085'], ['G04.152'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Surface immunoglobulin of guinea-pig leukaemic lymphocytes. | The surface immunoglobulin of the transplantable L2C leukaemia of strain 2 guinea-pigs has been investigated. The immunoglobulin is seen to be synthesized when the cells are maintained in culture, indicating its intrinsic origin. Immunolabelling of the cell surface and immunochemical study of the Fab released by limite... | ['Animals', 'Antibodies, Anti-Idiotypic', 'Antibody Formation', 'Binding Sites, Antibody', 'Binding, Competitive', 'Cell Membrane', 'Cells, Cultured', 'Epitopes', 'Fluorescent Antibody Technique', 'Guinea Pigs', 'Immunoglobulin Fab Fragments', 'Immunoglobulin Fragments', 'Immunoglobulin M', 'Iodine Radioisotopes', 'Leu... | 48,498 | [['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['G12.450.050.370.250'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.284.149'], ['A11.251'], ['D23.050.550'], ['E01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Outbreak of hemorrhagic fever with kidney syndrome in Egor'ev district of Moscow region]. | Epizootological, serological, and molecular virological analysis of an outbreak of hemorrhagic fever with renal syndrome (HFRS) in the Egoryevsk district of Moscow region (September 1995-January 1996) has been carried out. Hantavirus (Puumala) antigen and virus-specific antibodies were isolated from bank voles captured... | ['Animals', 'Disease Outbreaks', 'Disease Reservoirs', 'Hantaan virus', 'Hemorrhagic Fever with Renal Syndrome', 'Humans', 'Moscow'] | 10,971,964 | [['B01.050'], ['N06.850.290'], ['N06.850.520.203.250'], ['B04.820.480.750.440.400'], ['C01.925.782.147.420.400', 'C01.925.782.417.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.653', 'Z01.542.248.775.510']] | ['Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Isolation and structure elucidation of neofusapyrone from a marine-derived Fusarium species, and structural revision of fusapyrone and deoxyfusapyrone. | Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivat... | ['Anti-Infective Agents', 'Aspergillus', 'Candida albicans', 'Fermentation', 'Fusarium', 'Microbial Sensitivity Tests', 'Nuclear Magnetic Resonance, Biomolecular', 'Optical Rotation', 'Pseudomonas aeruginosa', 'Pyrones', 'Spectrometry, Mass, Fast Atom Bombardment', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ult... | 17,256,469 | [['D27.505.954.122'], ['B01.300.381.081'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['G02.111.158.249', 'G03.191.249'], ['B01.300.381.366'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E05.196.867.519.550'], ['G01.590.773'], ['B03.440.400.425.625.625.100', 'B03.660... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New CTA protocol and 2D-3D registration method for liver catheterization. | 2D-3D registration for angiographic liver interventions is an unsolved problem mainly because of two reasons. First, a suitable protocol for Computed Tomography Angiography (CTA) to contrast liver arteries is not used in clinical practice. Second, an adequate registration algorithm which addresses the difficult task of... | ['Algorithms', 'Angiography', 'Artificial Intelligence', 'Catheterization', 'Humans', 'Imaging, Three-Dimensional', 'Liver', 'Pattern Recognition, Automated', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiography, Interventional', 'Reproducibility of Results', 'Sensitivi... | 17,354,973 | [['G17.035', 'L01.224.050'], ['E01.370.350.700.060', 'E01.370.370.050'], ['G17.035.250', 'L01.224.050.375'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['A03.620'], ['L01.399.750'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Female marmoset monkeys (Callithrix jacchus) can be identified from the chemical composition of their scent marks. | The present study analyzed 42 organic solvent extracts of scent mark pools from five dominant female common marmosets by gas chromatography (GC) and combined GC and mass spectrometry. We determined whether there were qualitative or quantitative differences between the chemical composition of scent marks from individual... | ['Animals', 'Callithrix', 'Chromatography, Gas', 'Discriminant Analysis', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Group Structure', 'Male', 'Odorants', 'Organic Chemicals', 'Scent Glands', 'Sex Attractants', 'Signal Transduction', 'Volatilization'] | 11,418,490 | [['B01.050'], ['B01.050.150.900.649.313.988.400.600.150.150.114'], ['E05.196.181.349'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['E05.196.181.349.500', 'E05.196.566.500'], ['F01.829.316.274'], ['G16.500.275.640', 'N06.230.480'], ['D02'], ['A13.820'], ['D23.641.800'], ['G02.111.820', 'G04.835'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Use of end-tidal partial pressure of carbon dioxide to predict arterial partial pressure of carbon dioxide in harp seals during isoflurane-induced anesthesia. | OBJECTIVE: To evaluate the relationship between end-tidal partial pressure of CO(2) (ETCO(2)) and PaCO(2) in isoflurane-anesthetized harp seals.ANIMALS: Three 5-month-old 25- to 47-kg harp seals (Phoca groenlandica).PROCEDURES: PaCO(2) was determined in serial arterial samples from isoflurane-anesthetized seals and com... | ['Anesthetics, Inhalation', 'Animals', 'Blood Gas Analysis', 'Carbon Dioxide', 'Isoflurane', 'Partial Pressure', 'Phoca', 'Tidal Volume'] | 16,817,732 | [['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D02.355.601.570'], ['G01.374.715.714'], ['B01.050.150.900.649.313.750.250.700.600'], ['E01.370.386.700.485.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pentavalent antimonial inhibition of the osmotic effect of oxytocin on the isolated toad bladder. | The inhibition of osmotic stimulated water flow in the isolated toad bladder by 0.1 mM sodium stibogluconate (pentavalent antimony) is described. Pentavalent antimony on the serosal surface significantly inhibited oxytocin-induced water flow but when the drug was added to the mucosal surface only the effect of low oxyt... | ['Animals', 'Antimony Sodium Gluconate', 'Bufo marinus', 'Gluconates', 'Oxytocin', 'Pentoxifylline', 'Phosphodiesterase Inhibitors', 'Urinary Bladder', 'Water'] | 3,015,305 | [['B01.050'], ['D02.125', 'D02.241.081.844.322.060', 'D02.241.511.902.322.060', 'D09.811.308.060'], ['B01.050.150.900.090.180.210.580'], ['D02.241.081.844.322', 'D02.241.511.902.322', 'D09.811.308'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['D03.633.100.759.758.824.651.700'], ['D27.505.519.389.735'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. | Circadian clocks have evolved to synchronize physiology, metabolism and behaviour to the 24-h geophysical cycles of the Earth. Drosophila melanogaster's rhythmic locomotor behaviour provides the main phenotype for the identification of higher eukaryotic clock genes. Under laboratory light-dark cycles, flies show enhanc... | ['Animals', 'Biological Clocks', 'Circadian Rhythm', 'Cues', 'Darkness', 'Drosophila melanogaster', 'Environment', 'Female', 'Italy', 'Laboratories', 'Light', 'Male', 'Moon', 'Motor Activity', 'Phenotype', 'Seasons', 'Temperature', 'Time Factors', 'United Kingdom'] | 22,495,312 | [['B01.050'], ['G07.180.562.094'], ['G07.180.562.190'], ['F02.463.425.234'], ['G01.590.540.233'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G16.500.275', 'N06.230'], ['Z01.542.489'], ['J03.520', 'N02.278.487'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G01.060.075.730.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Comparison of porcine epidemic diarrhea viruses from Germany and the United States, 2014. | Since 2013, highly virulent porcine epidemic diarrhea virus has caused considerable economic losses in the United States. To determine the relation of US strains to those recently causing disease in Germany, we compared genomes and found that the strain from Germany is closely related to variants in the United States. | ['Animals', 'Coronavirus Infections', 'Genome, Viral', 'Germany', 'Phylogeny', 'Porcine epidemic diarrhea virus', 'Sequence Analysis, DNA', 'Swine', 'Swine Diseases', 'United States', 'Viral Proteins'] | 25,695,311 | [['B01.050'], ['C01.925.782.600.550.200'], ['G05.360.340.358.840'], ['Z01.542.315'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B04.820.578.500.540.150.075.937'], ['E05.393.760.700'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['Z01.107.567.875'], ['D12.776.964']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN | LESSONS LEARNED: This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline PTEN gene.Single-agent sirolimus, a mTOR inhibitor, suppressed mTOR signaling in surrogate human tissues without significant toxicity.BACKGROUND: Cowden syndrome is characterized by ... | ['Adult', 'Aged', 'Anti-Bacterial Agents', 'Female', 'Germ-Line Mutation', 'Hamartoma Syndrome, Multiple', 'Humans', 'Male', 'Middle Aged', 'PTEN Phosphohydrolase', 'Pilot Projects', 'Sirolimus', 'Young Adult'] | 31,350,329 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['G05.365.590.350'], ['C04.445.435', 'C04.651.435', 'C04.700.435', 'C16.320.700.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.277.352.650.850', 'D12.776.476.590', 'D12.776.624.776.695'], ['E05.318.372.750', 'E05.337... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spinal cord pathways involved in initiation of swimming in the stingray, Dasyatis sabina: spinal cord stimulation and lesions. | In spinally transected stingrays, electrical stimulation of a site just ventral to the dorsal root entry zone or a site in the intermediate portions of the lateral funiculus produced rhythmic swimming like movements of the contralateral pectoral fin. Electromyographic (EMG) records collected during cord-stimulated rhyt... | ['Animals', 'Cats', 'Electric Stimulation', 'Electromyography', 'Fishes', 'Locomotion', 'Neural Pathways', 'Spinal Cord', 'Swimming'] | 6,699,678 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.493'], ['G07.568.500', 'G11.427.410.568'], ['A08.612'], ['A08.186.854'], ['G11.427.410.568.800', 'G11.427.410.698.277.875', 'I03.350.875', 'I03.450.642.845.945.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Anti-TNF-á therapy reduces endothelial cell activation in non-diabetic ankylosing spondylitis patients. | Endothelial dysfunction can be detected by the presence of elevated levels of biomarkers of endothelial cell activation. In this study, we aimed to establish whether correlations of these biomarkers with characteristics of patients with ankylosing spondylitis (AS) exist. We also studied the effect of anti-TNF-á therapy... | ['Antirheumatic Agents', 'Biomarkers', 'Cardiovascular Diseases', 'Chemokine CCL2', 'E-Selectin', 'Endothelial Cells', 'Endothelium, Vascular', 'Female', 'Humans', 'Infliximab', 'Male', 'Spondylitis, Ankylosing', 'Tumor Necrosis Factor-alpha', 'Vascular Cell Adhesion Molecule-1'] | 26,143,161 | [['D27.505.954.329'], ['D23.101'], ['C14'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['A11... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Leprosy in elderly people and the profile of a retrospective cohort in an endemic region of the Brazilian Amazon. | BACKGROUND: Leprosy has a global presence; more than 180 thousand new cases were registered in 2013, 15% of which were found in the Americas. The elderly are a very susceptible demographic in terms of developing illnesses, mainly because of characteristics natural to the senescence of the human organism. This study's g... | ['Aged', 'Aged, 80 and over', 'Brazil', 'Cohort Studies', 'Drug Therapy, Combination', 'Female', 'Humans', 'Leprostatic Agents', 'Leprosy', 'Male', 'Middle Aged', 'Prevalence', 'Retrospective Studies', 'Severity of Illness Index'] | 31,479,442 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.954.122.085.777'], ['C01.150.252.410.040.552.475.371'], ['M01.060.116.630'], ['E05.318.308.985.52... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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