Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cystic fibrosis in New Zealand: incidence and mortality. | The incidence of and mortality from cystic fibrosis in New Zealand from 1960 to 1983, has been reviewed. Cystic fibrosis subjects have been located from data obtained from New Zealand paediatricians, the Cystic Fibrosis Association and hospital admission records. Mortality figures in the years 1960-1982 were also obtai... | ['Adolescent', 'Child', 'Child, Preschool', 'Cystic Fibrosis', 'Female', 'Humans', 'Infant', 'Male', 'New Zealand'] | 3,858,714 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['Z01.639.760.747', 'Z01.678.100.747']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
New approach to quantifying developmental variation in the dentition using serial microtomographic imaging. | Dental morphogenesis and cellular differentiation are expressed in the fully formed tooth by the topography of the dentin-enamel junction and outer enamel surface. These boundaries can be differentiated using a variety of imaging systems. In this study, we used serial microCT imaging to provide accurate 3D reconstructi... | ['Dental Enamel', 'Dentin', 'Dentition', 'Humans', 'Tomography, X-Ray Computed', 'Tooth'] | 15,662,618 | [['A14.549.167.900.255'], ['A14.549.167.900.280'], ['A03.556.500.379', 'A14.549.167'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['A14.549.167.860']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apolipoprotein A1 rs5070 A/G polymorphism with stroke subtypes in Taiwan. | BACKGROUND: Apolipoprotein A1 (ApoA1) is a structural protein of high-density lipoprotein cholesterol; ApoA1 is involved in lipid and cholesterol metabolism. This study evaluated the association of ApoA1 polymorphism (rs5070) with different stroke subtypes in Taiwanese individuals.METHODS: A total of 2139 cases, includ... | ['Aged', 'Apolipoprotein A-I', 'Cholesterol, HDL', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Intracranial Arteriosclerosis', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Stroke'] | 28,238,629 | [['M01.060.116.100'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.800', 'C14... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
UCSD's MedPics: implementation and impact on the curriculum. | MedPics is a computer-based image delivery system with supporting text fields and on-screen graphics to assist in key feature identification. It has been used by the University of California, San Diego as an integral part of the Human Disease course since 1992. Initially created to support pathology and histology, the ... | ['California', 'Computer-Assisted Instruction', 'Curriculum', 'Education, Medical, Undergraduate', 'Hematology', 'Histology', 'Humans', 'Image Processing, Computer-Assisted', 'Pathology', 'Program Evaluation', 'Schools, Medical'] | 8,130,582 | [['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['I02.903.771.500.208'], ['I02.158'], ['I02.358.399.450'], ['H02.403.429.445'], ['H01.158.100.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['H02.403.650'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['I02.783.495.552', 'N02.278... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
[Diagnostic potentials of NMR tomography of the kidneys of patients with symptomatic renal hypertension]. | Thirty seven patients with arterial hypertension of renal genesis (chronic diffuse glomerulonephritis, chronic pyelonephritis, renal cystic disease and congenital abnormalities) were subjected to NMR-tomography. The comparison group comprised 12 patients with essential hypertension and 18 normal individuals constituted... | ['Adolescent', 'Adult', 'Aged', 'Chronic Disease', 'Diagnosis, Differential', 'Glomerulonephritis', 'Humans', 'Hypertension, Renal', 'Kidney', 'Kidney Diseases, Cystic', 'Kidney Failure, Chronic', 'Magnetic Resonance Spectroscopy', 'Middle Aged', 'Polycystic Kidney Diseases', 'Pyelonephritis'] | 4,063,086 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['E01.171'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['A05.810.453'], ['C12.777.419.403', 'C13.351.968.419.403'], ['C12... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sub-wavelength plasmonic modes in a conductor-gap-dielectric system with a nanoscale gap. | We study guided modes in a conductor-gap-dielectric (CGD) system that includes a low-index dielectric gap layer of deep sub-wavelength thickness sandwiched between a conductor and a high-index dielectric cladding. Analysis of the dispersion equation for CGD modes provides an analytical estimation for the cut-off thickn... | ['Computer Simulation', 'Computer-Aided Design', 'Electric Conductivity', 'Equipment Design', 'Equipment Failure Analysis', 'Models, Theoretical', 'Nanostructures', 'Nanotechnology', 'Refractometry', 'Surface Plasmon Resonance'] | 20,173,855 | [['L01.224.160'], ['L01.224.108.150', 'L01.296.110.150'], ['G01.358.500.249.277'], ['E05.320'], ['E05.325.192'], ['E05.599'], ['J01.637.512'], ['H01.603', 'J01.897.520.600'], ['E05.196.808', 'H01.671.617.755'], ['E05.196.890', 'E05.601.043.700']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
A teaching skills assessment tool inspired by the Calgary-Cambridge model and the patient-centered approach. | OBJECTIVE: The aim of this study was to develop a descriptive tool for peer review of clinical teaching skills. Two analogies framed our research: (1) between the patient-centered and the learner-centered approach; (2) between the structures of clinical encounters (Calgary-Cambridge communication model) and teaching se... | ['Clinical Competence', 'Clinical Medicine', 'Communication', 'Education, Medical', 'Educational Measurement', 'Female', 'Humans', 'Male', 'Patient-Centered Care', 'Physician-Patient Relations', 'Reproducibility of Results', 'Students, Medical', 'Teaching', 'Teaching Materials'] | 26,680,755 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.200'], ['F01.145.209', 'L01.143'], ['I02.358.399'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.727.407'], ['F01.829.401.650.675', 'N05.300.660.625'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Anaesthesia for a patient undergoing thoracoscopic assisted trans-hiatal oesophagectomy. | We describe the anaesthetic management of an elderly woman who underwent thoracoscopically assisted trans-hiatal oesophagectomy. One-lung ventilation with insufflation of carbon dioxide was necessary for adequate surgical access. Potential intra-operative problems included hypoxaemia during one-lung ventilation, medias... | ['Aged', 'Aged, 80 and over', 'Anesthesia', 'Blood Gas Analysis', 'Blood Pressure', 'Esophagectomy', 'Female', 'Heart Rate', 'Humans', 'Hyperventilation', 'Intraoperative Complications', 'Oxygen Consumption', 'Premedication', 'Respiration, Artificial', 'Thoracoscopy'] | 8,542,856 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.155'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E04.210.346'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.618.501', 'C23.888.852.59... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Death of a scuba diver caused by vomiting and panic: a case report. | Scuba diving fatalities are rare and sometimes extremely difficult to explain. A thorough forensic investigation, conducted by a qualified team, helps avoid possible later questions and doubts, family concerns and judicial matters, since a significant body of evidence is lost after the body of the victim is buried or t... | ['Adult', 'Conjunctiva', 'Diving', 'Drowning', 'Eating', 'Eye Hemorrhage', 'Forensic Pathology', 'Humans', 'Male', 'Panic', 'Sports Equipment', 'Vomiting'] | 20,190,635 | [['M01.060.116'], ['A09.371.060.200', 'A09.371.337.168'], ['I03.450.642.845.945.500.110', 'N06.230.150.150'], ['C23.550.260.393', 'C26.304', 'N06.850.135.696'], ['G07.203.650.283', 'G10.261.330'], ['C11.290', 'C23.550.414.756', 'C23.888.307.500'], ['H02.403.330.300', 'H02.403.650.249', 'I01.198.780.937.460'], ['B01.050... | ['Named Groups [M]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
Association of PTPN22 polymorphism and its correlation with Graves' disease susceptibility in Polish adult population-A preliminary study. | BACKGROUND: Susceptibility to Graves' disease (GD) is determined by various genetic factors; the gene encoding protein tyrosine phosphatase (PTPN22) may be one of those associated with higher risk of GD. The aim was to estimate the association of the PTPN22 gene polymorphism rs2476601:c.C>T (c.1858C>T) with the predisp... | ['Adult', 'Alleles', 'Case-Control Studies', 'Disease Susceptibility', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Graves Disease', 'Humans', 'Male', 'Poland', 'Polymorphism, Single Nucleotide', 'Preliminary Data', 'Protein Tyrosine Phosphatase, Non-Receptor Type 22', 'Risk Factors'] | 30,938,100 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.687', 'G07.100.250'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Characterization of two monoclonal antibodies against teguments of adult and schistosomula of Schistosoma japonicum. | Two monoclonal antibodies (McAbs) were produced from BALB/c mice hyperimmunized with tegumental extract of Schistosoma japonicum (Chinese strain). The two McAbs were characterized with regard to antibody isotype, antigen binding specificity and parasite stage specificity. One McAb, 8G9-5, was identified as IgM, whereas... | ['Animals', 'Antibodies, Monoclonal', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Fluorescent Antibody Technique', 'Immunoblotting', 'Mice', 'Mice, Inbred BALB C', 'Schistosoma japonicum'] | 1,725,481 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D23.050.550'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
tomm22 | The liver has a highly regenerative capacity. In the normal liver, hepatocytes proliferate to restore lost liver mass. However, when hepatocyte proliferation is impaired, biliary epithelial cells (BECs) activate and contribute to hepatocytes. We previously reported in zebrafish that upon severe hepatocyte ablation, BEC... | ['Animals', 'Animals, Genetically Modified', 'Biliary Tract', 'Cell Death', 'Cell Proliferation', 'Gene Knockdown Techniques', 'Green Fluorescent Proteins', 'Hepatocytes', 'Larva', 'Liver', 'Liver Regeneration', 'Macrophages', 'Mitochondrial Membrane Transport Proteins', 'Models, Animal', 'Oligonucleotides, Antisense',... | 28,251,883 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A03.159'], ['G04.146'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.393.335.500'], ['D12.776.532.265'], ['A11.436.348'], ['B05.500.500', 'G07.345.500.550.500.500'], ['A03.620'], ['G10.261.475', 'G16.762.468'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.6... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incorporation of beta-lactoglobulin in a lipid/porphyrin monolayer at the air--water interface. | A catanionic lipid/porphyrin monolayer was formed at the air-water interface by the tetra-anionic porphyrin, tetra-sodium-meso-tetra(4-sulfonatophenyl)porphine (TSPP), mixed with the cationic lipid dioctadecyldimethylammonium bromide (DODAB) in a 1:4 molar ratio. This binary mixture (TSPP/4DODAB) was used as the incorp... | ['Animals', 'Cattle', 'Hydrophobic and Hydrophilic Interactions', 'Lactoglobulins', 'Lipids', 'Models, Chemical', 'Porphyrins', 'Quaternary Ammonium Compounds', 'Static Electricity'] | 14,706,742 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G02.409'], ['D12.776.256.159.750.816.500', 'D12.776.377.457'], ['D10'], ['E05.599.495'], ['D03.383.129.578.840.500', 'D03.633.400.909.500', 'D04.345.783.500', 'D23.767.727'], ['D01.625.062.500', 'D02.092.877', 'D02.675.276'], ['G01.358.500.249.820']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Targeting liposomes with protein drugs to the blood-brain barrier in vitro. | In this study, we aim to target pegylated liposomes loaded with horseradish peroxidase (HRP) and tagged with transferrin (Tf) to the BBB in vitro. Liposomes were prepared with the post-insertion technique: micelles of polyethylene glycol (PEG) and PEG-Tf were inserted into pre-formed liposomes containing HRP. Tf was me... | ['Animals', 'Blood-Brain Barrier', 'Cattle', 'Cells, Cultured', 'Drug Delivery Systems', 'Endothelial Cells', 'Horseradish Peroxidase', 'Liposomes', 'Polyethylene Glycols', 'Proteins', 'Receptors, Transferrin', 'Spectrophotometry, Atomic', 'Transferrin'] | 15,911,226 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['E02.319.300'], ['A11.436.275'], ['D08.811.682.732.512'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], [... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Association of alpha-adducin and angiotensin converting enzyme gene polymorphisms with salt-sensitive hypertension and early renal injury]. | OBJECTIVE: To investigate the association between the alpha-adducin gene G460T, angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphisms and salt-sensitive hypertension and early renal injury in Chinese people.METHODS: The case-control study was performed in 200 essential hypertension (EH) and 200 nor... | ['Adult', 'Albuminuria', 'Calmodulin-Binding Proteins', 'Female', 'Genotype', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Peptidyl-Dipeptidase A', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', 'Radioimmunoassay'] | 18,393,230 | [['M01.060.116'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D12.776.157.142'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D08.811.277.656.350.350.687'], ['E05.393.620.500'], ['G05.365.795'], ['G05.365.795.595'], ['E01.370.384.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of glucan on Leishmania major infection in BALB/c mice. | The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection,... | ['Animals', 'Glucans', 'Leishmania tropica', 'Leishmaniasis', 'Liver', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Organ Size', 'Spleen', 'Time Factors'] | 3,585,970 | [['B01.050'], ['D05.750.078.562', 'D09.698.365'], ['B01.268.475.868.488.680'], ['C01.610.752.300.500', 'C01.610.858.560', 'C01.920.813', 'C17.800.838.775.560'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['E01.370.600.115... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcineurin Subunits A and B Interact to Regulate Growth and Asexual and Sexual Development in Neurospora crassa. | Calcineurin is a calcium/calmodulin dependent protein phosphatase in eukaryotes that consists of a catalytic subunit A and a regulatory subunit B. Previous studies in the filamentous fungus Neurospora crassa had suggested that the catalytic subunit of calcineurin might be an essential protein. We generated N. crassa st... | ['Calcineurin', 'Copper', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Genetic Vectors', 'Hyphae', 'Immunoprecipitation', 'Neurospora crassa', 'Phenanthrolines', 'Point Mutation', 'Promoter Regions, Genetic', 'Protein Subunits'] | 27,019,426 | [['D08.811.277.352.650.625.150', 'D12.644.360.087', 'D12.776.476.087'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D12.776.354'], ['G05.308.330'], ['G05.360.337'], ['A19.687.400'], ['E05.196.150.639', 'E05.478.605'], ['B01.300.107.800.629.564'], ['D03.633.300.669'], ['G05.365.590.675'], ['G02.111.570.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IncMD: incremental trie-based structural motif discovery algorithm. | The discovery of common RNA secondary structure motifs is an important problem in bioinformatics. The presence of such motifs is usually associated with key biological functions. However, the identification of structural motifs is far from easy. Unlike motifs in sequences, which have conserved bases, structural motifs ... | ['Algorithms', 'Base Sequence', 'Computational Biology', 'Computer Simulation', 'Data Mining', 'Databases, Nucleic Acid', 'Models, Molecular', 'Nucleic Acid Conformation', 'RNA'] | 25,362,841 | [['G17.035', 'L01.224.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['L01.313.500.750.280.199', 'L01.470.625'], ['L01.313.500.750.300.188.400.300.500', 'L01.313.500.750.300.188.400.325.630', 'L01.470.750.750.300.500', 'L01.470.750.750.325.630'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Clinical features and neuroimaging findings of 12 patients with acute disseminated encephalomyelitis involved in corpus callosum]. | OBJECTIVE: To summarize the clinical features and neuroimaging findings of the patients with acute disseminated encephalomyelitis (ADEM) involved in corpus callosum (CC) so as to distinguish it from other diseases.METHODS: A total of 12 ADEM patients with the involvement of CC during the period of 2010-2012 were recrui... | ['Adolescent', 'Adult', 'Child', 'Corpus Callosum', 'Encephalomyelitis, Acute Disseminated', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neuroimaging', 'Retrospective Studies', 'Young Adult'] | 23,328,373 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['A08.186.211.200.885.800.750'], ['C10.114.375.225', 'C10.228.140.695.562.225', 'C10.314.350.225', 'C20.111.258.250.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.578', 'E01.370.376.537', 'E05.629'],... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The API ZYM system in the identification of Gram-negative anaerobes. | The API ZYM reactions of type species of Gram-negative anaerobes representative of those encountered in human infections and of 56 clinical isolates of such organisms, identified by conventional techniques, were investigated. The API ZYM test clearly distinguished between the different genera and species examined and a... | ['Bacteriological Techniques', 'Culture Media', 'Gram-Negative Anaerobic Bacteria'] | 326,815 | [['E01.370.225.875.150', 'E05.200.875.150'], ['D27.720.470.305', 'E07.206'], ['B03.440.425']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of tolerance to paternal antigens on placental and fetal weight in the mouse. | Placental and fetal weight was measured on the 16th day of pregnancy in normal and tolerant mice. Placental weight was increased in A mice tolerant to C57BL/10 mice only when donor cells from males were used. Fetal weight was unaffected. | ['Animals', 'Antigens', 'Female', 'Fetus', 'Immune Tolerance', 'Litter Size', 'Mice', 'Mice, Inbred Strains', 'Organ Size', 'Placenta', 'Pregnancy'] | 621,684 | [['B01.050'], ['D23.050'], ['A16.378'], ['G12.535.425'], ['G08.686.530', 'G08.686.784.769.498.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['A16.710'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. | Mitotic cyclins are abruptly degraded at the end of mitosis by a cell-cycle-regulated ubiquitin-dependent proteolytic system. To understand how cyclin is recognized for ubiquitin conjugation, we have performed a mutagenic analysis of the destruction signal of mitotic cyclins. We demonstrate that an N-terminal cyclin B ... | ['Amino Acid Sequence', 'Anaphase', 'Animals', 'Binding Sites', 'Cyclins', 'Lysine', 'Mitosis', 'Molecular Sequence Data', 'Recombinant Proteins', 'Sea Urchins', 'Sequence Deletion', 'Sequence Homology, Amino Acid', 'Substrate Specificity', 'Ubiquitins', 'Xenopus'] | 8,885,231 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G04.144.220.220.687.222', 'G04.144.220.220.781.050', 'G05.113.220.687.250', 'G05.113.220.781.050'], ['B01.050'], ['G02.111.570.120'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476.262'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['G04.144.220.220.781... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Troponin must be measured before and after PCI to diagnose procedure-related myocardial injury. | OBJECTIVE: To evaluate troponin I >99th percentile of normal as a criterion for myocardial injury after percutaneous coronary intervention (PCI).DESIGN: Troponin I and creatine kinase monobasic (CK-MB) were measured in 327 patients before and after percutaneous transluminal coronary angioplasty (PTCA) with stent implan... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Biomarkers', 'Cohort Studies', 'Coronary Artery Disease', 'Creatine Kinase', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Predictive Value of Tests', 'Probability', 'Prognosis', 'Risk Factors', 'Sensitivity and Specificity', 'Time Factors', 'Treatment ... | 15,204,231 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['D23.101'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Substance use in youth at risk for psychosis. | BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. Some evidence suggests people at-risk for psychosis have high rates of substance use. We aimed to assess substance use in a help-seeking cohort, comparing those at-risk and not at-risk for p... | ['Adolescent', 'Adult', 'Child', 'Cohort Studies', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Mental Health Services', 'Multivariate Analysis', 'Patient Acceptance of Health Care', 'Psychotic Disorders', 'Regression Analysis', 'Risk', 'Substance-Related Disorders', 'Young Adult'] | 27,590,573 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.408', 'N02.421.461'], ['E05.318.740.150.500', 'N05.715.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Excluded volume effects on the refolding and assembly of an oligomeric protein. GroEL, a case study. | We have studied the effect of macromolecular crowding reagents, such as polysaccharides and bovine serum albumin, on the refolding of tetradecameric GroEL from urea-denatured protein monomers. The results show that productive refolding and assembly strongly depends on the presence of nucleotides (ATP or ADP) and backgr... | ['Adenosine Diphosphate', 'Adenosine Triphosphatases', 'Adenosine Triphosphate', 'Chaperonin 10', 'Chaperonin 60', 'Escherichia coli', 'Kinetics', 'Macromolecular Substances', 'Microscopy, Electron', 'Protein Conformation', 'Protein Denaturation', 'Protein Folding', 'Protein Subunits', 'Recombinant Proteins', 'Spectrop... | 11,020,386 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D08.811.277.040.025'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D12.776.580.216.210.590.500'], ['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['B03.440.450.425.325.300', 'B03.66... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Administration of bone marrow mesenchymal stem cells attenuates inflammation of rats with sepsis]. | Objective To investigate the therapeutic effects of bone marrow-derived mesenchymal stem cells (BMSCs) in rats with sepsis. Methods Forty-eight Wistar rats were divided into blank group, sham group, model group and treatment group. Sepsis model was made using cecum ligation and puncture (CLP). BMSCs were extracted and ... | ['Animals', 'Bone Marrow Cells', 'Bone Marrow Transplantation', 'Cell Transplantation', 'Cells, Cultured', 'Humans', 'Interleukin-17', 'Interleukin-6', 'Male', 'Mesenchymal Stem Cell Transplantation', 'Mesenchymal Stem Cells', 'Rats', 'Rats, Wistar', 'Sepsis', 'Tumor Necrosis Factor-alpha'] | 27,609,567 | [['B01.050'], ['A11.148', 'A15.378.316'], ['E02.095.147.725.040', 'E04.936.580.040'], ['E02.095.147.500', 'E04.936.225'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.517', 'D12.776.467.374.465.517', 'D23.529.374.465.517'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental analysis of the minimally invasive plate osteosynthesis technique applied with non-locking screws and screw locking elements. | Minimally invasive plate osteosynthesis (MIPO) is an effective surgical technique in the repair of humeral and tibial shaft fractures. There is some controversy as to the minimum number of screws required to ensure correct stability to promote healing, especially when dealing with low quality bones. This work compared ... | ['Aged', 'Aged, 80 and over', 'Bone Plates', 'Bone Screws', 'Female', 'Humans', 'Materials Testing', 'Minimally Invasive Surgical Procedures', 'Osteoporosis', 'Tibia'] | 25,183,044 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'], ['E04.502'], ['C05.116.198.579', 'C18.452.104.579'], ['A02.83... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Complex formation by positive and negative translational regulators of GCN4. | GCN4 is a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae whose expression is regulated by amino-acid availability at the translational level. GCD1 and GCD2 are negative regulators required for the repression of GCN4 translation under nonstarvation conditions that is mediated by u... | ['Amino Acids', 'Animals', 'Cricetinae', 'DNA-Binding Proteins', 'Eukaryotic Initiation Factor-2', 'Eukaryotic Initiation Factor-2B', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Immunoblotting', 'Peptide Elongation Factors', 'Plasmids', 'Polyribosomes', 'Protein Biosynthesis', 'Protein Kinases', 'Saccharo... | 2,038,327 | [['D12.125'], ['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['D12.776.260'], ['D12.776.835.725.868.249'], ['D12.644.360.325.300.050', 'D12.776.476.325.300.050', 'D12.776.835.725.868.374'], ['D12.776.354'], ['G05.308.330'], ['E05.478.566.320', 'E05.601.470.320'], ['D12.776.835.700'], ['G05.360.600'], ['A11.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Perception of shift work, burnout and sleep disturbances: a study among call centre operators]. | BACKGROUND: Shift work is often considered to be a factor that can negatively affect health and sleep quality. However, it is usually considered as a structural factor of the job and not as a perception of a work demand.OBJECTIVES: The study aimed at analyzing the relationship between perception of shift work, burnout ... | ['Adolescent', 'Adult', 'Burnout, Professional', 'Female', 'Hotlines', 'Humans', 'Italy', 'Job Satisfaction', 'Male', 'Mental Fatigue', 'Middle Aged', 'Sleep Disorders, Circadian Rhythm', 'Surveys and Questionnaires', 'Telephone', 'Workload', 'Workplace'] | 26,822,246 | [['M01.060.057'], ['M01.060.116'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['N02.421.297.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['F02.784.692.425'], ['C23.888.369.500', 'F01.145.126.937'], ['M01.060.116.630'], ['C10.281.800', 'C10.886.425.200', 'C24.900', 'F0... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. | Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was overactivated in several chronic kidney disease models, and that Rac1 inhibitors ameliorated renal injury, in part via inhibition of inflammation, but the detail... | ['Animals', 'Biomarkers', 'Cell Line', 'Cell Lineage', 'Chemokine CCL2', 'Chemokine CXCL1', 'Chemokine CXCL2', 'Culture Media, Conditioned', 'Cytokines', 'Gene Deletion', 'Gene Expression Regulation', 'Inflammation', 'Interleukin-6', 'Kidney', 'Lipopolysaccharides', 'Macrophages', 'Male', 'Mice', 'Mice, Knockout', 'Mon... | 26,939,003 | [['B01.050'], ['D23.101'], ['A11.251.210'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['D12.644.276.374.200.120.050', 'D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Resection of blind ending bifid ureter in a patient with grade V vesicoureteric reflux. | Blind-ending bifid ureter is an extremely rare congenital anomaly. The authors report on a 13-year-old boy who presented with a previous diagnosis of right duplicated ureter and who had undergone a bilateral ureteroneocystostomy for vesicoureteral reflux in another clinic. The revision showed right blind-ending bifid u... | ['Adolescent', 'Diagnosis, Differential', 'Follow-Up Studies', 'Humans', 'Male', 'Severity of Illness Index', 'Ureter', 'Urodynamics', 'Urography', 'Urologic Surgical Procedures', 'Vesico-Ureteral Reflux'] | 20,306,926 | [['M01.060.057'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['A05.810.776'], ['G08.852.898'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Caregivers of North African origin faced with Islamist radicalisation]. | Supporting teenagers in search of ideality sometimes requires accepting and understanding the movements present in the process of Islamist radicalisation. It is therefore necessary to understand the implicit dimension to this notion of radicalisation and what it arouses in each of us. For caregivers with a North Africa... | ['Adolescent', 'Africa, Northern', 'Caregivers', 'Countertransference', 'Emigrants and Immigrants', 'Humans', 'Islam', 'Professional-Patient Relations', 'Social Identification', 'Terrorism'] | 31,208,580 | [['M01.060.057'], ['Z01.058.266'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F04.754.720.864.363'], ['M01.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.844.275'], ['F01.829.401.650', 'N05.300.660'], ['F01.145.813.708'], ['I01.198.240.856.800', 'I01.880.735.900.800']] | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Planning for district mental health services in South Africa: a situational analysis of a rural district site. | The shift in emphasis to universal primary health care in post-apartheid South Africa has been accompanied by a process of decentralization of mental health services to district level, as set out in the new Mental Health Care Act, no. 17, of 2002 and the 1997 White Paper on the Transformation of the Health System. This... | ['Attitude of Health Personnel', 'Deinstitutionalization', 'Delivery of Health Care, Integrated', 'Emergency Services, Psychiatric', 'Health Plan Implementation', 'Health Resources', 'Health Services Accessibility', 'Humans', 'Interviews as Topic', 'Mental Health Services', 'Organizational Case Studies', 'Politics', 'P... | 19,147,698 | [['F01.100.050', 'N05.300.100'], ['E02.760.415.280', 'N02.421.585.415.280'], ['N04.590.374.142', 'N05.300.262'], ['F04.408.525', 'N02.421.297.200'], ['N03.349.300'], ['N03.349.340', 'N05.300.420'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520'... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Monitoring and evaluation of blood pressure changes with a home healthcare system. | We investigated changes in blood pressure with exercise, including walking and ergometer training, sleep, and body weight. Blood pressure was monitored over a period of about 1 year in 61 subjects in Osaka, Japan. The morning systolic blood pressures were analyzed using multivariate regression analysis, and the correla... | ['Adult', 'Aged', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Exercise', 'Exercise Therapy', 'Female', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Regression Analysis', 'Sleep'] | 21,606,038 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['G11.427.410.698.277', 'I03.350'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Role of the C-type lectin receptors MCL and DCIR in experimental colitis. | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Though its exact etiology is still unclear, it is proposed that an imbalance in the intestinal homeostasis leads to a disturbed interaction between commensal microbiota and the mucosal immune system. Previous studies have... | ['Animals', 'Antigen-Presenting Cells', 'Colitis', 'Cytokines', 'Dendritic Cells', 'Dextran Sulfate', 'Disease Models, Animal', 'Gene Expression', 'Lectins, C-Type', 'Lymphocyte Activation', 'Macrophages', 'Mice', 'Mice, Knockout', 'Microbiota', 'Protein Binding', 'T-Lymphocytes'] | 25,068,517 | [['B01.050'], ['A11.066', 'A15.382.066'], ['C06.405.205.265', 'C06.405.469.158.188'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D09.698.365.272.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['D12.776.503.280'], ['E... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of histology on prognosis of patients with early-stage cervical cancer treated with radical surgery. | OBJECTIVE: To examine the effect of carcinoma cell type on tumor characteristics, tumor spread, tumor recurrence, and survival of patients with early-stage cervical cancer who had radical hysterectomy and pelvic lymphadenectomy.METHOD: Data from 499 patients with stage IA to IIA cervical carcinoma who received primary ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Carcinoma, Adenosquamous', 'Carcinoma, Squamous Cell', 'Disease-Free Survival', 'Female', 'Humans', 'Hysterectomy', 'Lymph Node Excision', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Pelvis', 'Prognosis', 'Retrospective Studies', 'Thailand', 'Treatment Outcome'... | 21,885,048 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['C04.557.435.250', 'C04.557.470.200.150'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.05... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Population aging: opportunity for business expansion, an invitational paper presented at the Asia-Pacific Economic Cooperation (APEC) International Workshop on Adaptation to Population Aging Issues, July 17, 2017, Ha Noi, Viet Nam. | A longer life brings opportunities for older adults and their families as well as for their communities. Commercial businesses can be successful in innovating on these opportunities and achieving business expansion when they better understand the market dynamics and spectrum of older adults as consumers and view them m... | ['Aged', 'Aging', 'Asia', 'Commerce', 'Consumer Behavior', 'Evidence-Based Practice', 'Geriatric Assessment', 'Government', 'Health Behavior', 'Health Personnel', 'Health Promotion', 'Humans', 'International Cooperation', 'Longevity', 'Motivation', 'Noncommunicable Diseases', 'Nutrition Assessment', 'Policy', 'Populati... | 29,636,085 | [['M01.060.116.100'], ['G07.345.124'], ['Z01.252'], ['J01.219'], ['F01.145.236'], ['H02.249'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['I01.409', 'N03.540.348'], ['F01.145.488'], ['M01.526.485', 'N02.360'], ['I02.233.332.445', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Determination of blood lead in dried blood-spot specimens by Zeeman-effect background corrected atomic absorption spectrometry. | A simple procedure for the determination of blood-lead levels in dried blood-spot filter-paper specimens is described. A 3/16 inch dried blood spot was analysed by a method involving extraction of the lead into 1.25% (NH4)2HPO4-0.5% Triton X-100 solution. A matrix-based calibration was used for analysis, with use of a ... | ['Humans', 'Lead', 'Specimen Handling', 'Spectrophotometry, Atomic'] | 1,503,233 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['E01.370.225.998', 'E05.200.998'], ['E05.196.712.726.551', 'E05.196.867.826.551']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Action of 7-oxa-13-prostynoic acid on rat uterine contractility and sensitivity to PGF-2 alpha and angiotensin II. | The action of 7-oxa-13-prostynoic acid on spontaneous contractions and on PGF-2alpha and angiotensin II elicited contractions has been studied on rat uteri excised during pro and metaoestrus. At the concentration of 5 x 10-6M, the compound does not alter the spontaneous contractions of proestrus uteri and suppresses th... | ['Angiotensin II', 'Animals', 'Depression, Chemical', 'Dose-Response Relationship, Drug', 'Fatty Acids, Unsaturated', 'Female', 'Prostaglandin Antagonists', 'Prostaglandins F', 'Rats', 'Stimulation, Chemical', 'Uterine Contraction'] | 1,169,797 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['G07.690.773.750'], ['G07.690.773.875', 'G07.690.936.500'], ['D10.251.355'], ['D06.347.710', 'D27.505.696.399.450.710'], ['D10.251.355.255.550.400', 'D23.469.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti-tumoral effects of a trypsin inhibitor derived from buckwheat in vitro and in vivo. | Native buckwheat, a common component of food products and medicine, has been observed to inhibit cancer cell proliferation in vitro. The aim of the present study was to evaluate the in vitro and in vivo anti-tumoral effects of recombinant buckwheat trypsin inhibitor (rBTI) on hepatic cancer cells and the mechanism of a... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Caspase 3', 'Caspase 8', 'Caspase 9', 'Cell Line', 'Cell Proliferation', 'Cytochromes c', 'DNA Fragmentation', 'Fagopyrum', 'Female', 'Humans', 'Liver Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'Mitochondria', 'Transplantation, Heterologous... | 25,901,645 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.55... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation, propagation and preliminary characterisation of Anaplasma phagocytophilum from roe deer (Capreolus capreolus) in the tick cell line IDE8. | Anaplasma phagocytophilum is an obligate intracellular bacterium causing granulocytic anaplasmosis in dogs, horses, and humans and tick-borne fever of ruminants. The bacterium has been detected in a variety of other mammals including wild ruminants without overt clinical signs of disease. Isolates in cell culture have ... | ['Anaplasma phagocytophilum', 'Animals', 'Animals, Wild', 'Base Sequence', 'Cell Line', 'DNA, Bacterial', 'DNA, Ribosomal', 'Deer', 'Ehrlichiosis', 'Genes, Bacterial', 'Germany', 'Molecular Sequence Data', 'Phylogeny', 'Prevalence', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Ticks'] | 22,108,013 | [['B03.440.664.750.050.600', 'B03.660.050.783.500.050.600'], ['B01.050'], ['B01.050.050.300'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D13.444.308.212'], ['D13.444.308.475'], ['B01.050.150.900.649.313.500.380.373'], ['C01.150.252.400.054.750', 'C01.150.252.400.285', 'C01.920.930.30... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Portal derivation surgery in children. A long-term follow-up report. | Eight children and two adults with portal hypertension were treated by portal diversion surgery. In all cases recurrent gastro-intestinal bleeding from esophageal varices was the indication for shunt-operation. Still in early childhood, three of these patients had had a splenectomy in other hospitals: one emergency spl... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Esophageal and Gastric Varices', 'Female', 'Follow-Up Studies', 'Gastrointestinal Hemorrhage', 'Humans', 'Hypertension, Portal', 'Male', 'Portasystemic Shunt, Surgical'] | 6,977,979 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C06.405.117.240', 'C06.552.494.414'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.494'], ['E04.035.760'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Putative suppressing effect of IgG Fc-conjugated haemagglutinin (HA) stalk of influenza virus H7N9 on the neutralizing immunogenicity of Fc-conjugated HA head: implication for rational design of HA-based influenza vaccines. | The emergence of influenza A H7N9 in infection has posed a great threat to public health globally. Poor immunogenicity of H7N9 haemagglutinin (HA) is a major obstacle to the development of an effective H7N9 vaccine. Here, we found that the vaccine containing the H7HA head conjugated with IgG Fc (Hd-Fc) induced strong n... | ['Animals', 'Antibodies, Neutralizing', 'Antibodies, Viral', 'Disease Models, Animal', 'Drug Carriers', 'Female', 'Hemagglutinin Glycoproteins, Influenza Virus', 'Immunoglobulin Fc Fragments', 'Influenza A Virus, H7N9 Subtype', 'Influenza Vaccines', 'Mice, Inbred BALB C', 'Orthomyxoviridae Infections'] | 26,653,217 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D26.255.260', 'E02.319.300.380'], ['D12.776.964.970.880.345.500'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyperplastic fundic gland polyp of the stomach. | A case of a solitary pedunculated gastric polyp occurring in the fundic mucosa of a 47-year-old woman is reported because of its unique morphology. The polyp showed a peculiar lobulated configuration supported by smooth muscle bundles, and its epithelial component was composed mainly of a proliferation of relatively no... | ['Female', 'Gastric Fundus', 'Gastric Mucosa', 'Humans', 'Hyperplasia', 'Middle Aged', 'Polyps', 'Stomach Neoplasms'] | 6,670,558 | [['A03.556.875.875.419'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['M01.060.116.630'], ['C23.300.825'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nitrogenase model complexes [Cp*Fe(mu-SR(1))2(mu-eta(2)-R(2)N=NH)FeCp*] (R(1) = Me, Et; R(2) = Me, Ph; Cp* = eta(5)-C5Me5): synthesis, structure, and catalytic N-N bond cleavage of hydrazines on diiron centers. | The reactions of [Cp*Fe(mu-SR1)3FeCp*] (Cp* = eta5-C5Me5; R1 = Et, Me) with 1.5 equiv R2NHNH2 (R2 = Ph, Me) give the mu-eta2-diazene diiron thiolate-bridged complexes [Cp*Fe(mu-SR1)2(mu-eta2-R2N NH)FeCp*], along with the formation of PhNH2 and NH3. These mu-eta2-diazene diiron thiolate-bridged complexes exhibit excelle... | ['Biocatalysis', 'Hydrazines', 'Iron', 'Iron Compounds', 'Methylation', 'Models, Biological', 'Models, Molecular', 'Molecular Structure', 'Nitrogenase', 'Protein Binding', 'Sulfur'] | 18,954,139 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['D02.442'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.490'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['E05.599.395'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D08.811.682.647'], ['G02.111.679', 'G03.808'], ['D01.268.185.900']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evolution of high-intensity basal ganglia lesions on T1-weighted MR in neurofibromatosis type 1. | PURPOSE: To characterize the temporal evolution of the foci of T1 shortening in basal ganglia lesions in patients with neurofibromatosis type 1 (NF-1).METHODS: A retrospective review of MR images of 37 patients with NF-1 revealed 8 patients in whom regions of T1 shortening were noted in the basal ganglia. We reviewed s... | ['Adolescent', 'Basal Ganglia', 'Basal Ganglia Diseases', 'Brain Neoplasms', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Male', 'Neurofibromatosis 1', 'Retrospective Studies', 'Sensitivity and Specificity'] | 8,730,197 | [['M01.060.057'], ['A08.186.211.200.885.287.249'], ['C10.228.140.079'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.3... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Effects of immunosuppressive therapy in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome during ongoing eculizumab treatment. | A 65-year-old woman experienced a hemolytic attack triggered by sepsis. She presented with markedly increased CD55(-) CD59(-) erythrocytes and the signs of bone marrow failure, which led to a diagnosis of aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome. There was a possibility of increasing hemoly... | ['Aged', 'Anemia, Aplastic', 'Anti-Bacterial Agents', 'Antibodies, Monoclonal, Humanized', 'Antilymphocyte Serum', 'Bacteremia', 'Blood Transfusion', 'Combined Modality Therapy', 'Complement Inactivating Agents', 'Cyclosporine', 'Escherichia coli Infections', 'Female', 'Granulocyte Colony-Stimulating Factor', 'Hemoglob... | 24,429,452 | [['M01.060.116.100'], ['C15.378.071.085', 'C15.378.190.223.250'], ['D27.505.954.122.085'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems. | This study investigated the effects of stress on brain dopamine receptor densities in two inbred strains of mice. Analysis of [3H]SCH23390 binding by quantitative autoradiography revealed that repeated restraint stress significantly increases D1-like receptor density in the nucleus accumbens of mice of the DBA/2 strain... | ['Animals', 'Corpus Striatum', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Nucleus Accumbens', 'Receptors, Dopamine', 'Species Specificity', 'Stress, Physiological', 'Substantia Nigra'] | 9,522,373 | [['B01.050'], ['A08.186.211.200.885.287.249.487'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.520.500', 'B01.050.150.900.649.313.992.635.505.500.400.500'], ['A08.186.211.200.885.287.249.487.775.500'], ['D12.776.5... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integration of oncology and palliative care: a systematic review. | BACKGROUND: Both the American Society of Clinical Oncology and the European Society for Medical Oncology strongly endorse integrating oncology and palliative care (PC); however, a global consensus on what constitutes integration is currently lacking. To better understand what integration entails, we conducted a systema... | ['Humans', 'Medical Oncology', 'Neoplasms', 'Palliative Care'] | 25,480,826 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429.515'], ['C04'], ['E02.760.666', 'N02.421.585.666']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Local application of calcium-modulating agents to a crushed goldfish optic nerve modifies visual recovery. | The effects of various Ca2+-modulating agents on regeneration in the optic nerve of goldfish were determined by assaying recovery of visual function. One to three daily applications of the agents were made at the site of an optic nerve crush beginning within 3 days after the lesion. Application of calcium ionophore A-2... | ['Animals', 'Calcimycin', 'Calcium', 'Cyprinidae', 'Dimethyl Sulfoxide', 'Egtazic Acid', 'Goldfish', 'Nerve Crush', 'Nerve Regeneration', 'Optic Nerve', 'Optic Nerve Injuries'] | 6,420,179 | [['B01.050'], ['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.493.200.244'], ['D02.886.640.150'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['B01.050.150.900.493.200.244.248.480'], ['E04.525.210.560'], ['G11.561.585', 'G16.762.611'], ['A08.800.800.120.680'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanism of resistance and antibacterial susceptibility in extended-spectrum â-lactamase phenotype Klebsiella pneumoniae and Klebsiella oxytoca isolated between 2000 and 2010 in Japan. | Clinical isolates of Klebsiella pneumoniae and Klebsiella oxytoca collected from 20 Japanese medical facilities between 2000 and 2010 were analysed to evaluate the mechanisms of resistance and antibacterial susceptibilities to 14 antimicrobials. Overall, eight of 484 (1.6%) K. pneumoniae and 19 of 359 (5.3%) K. oxytoca... | ['Anti-Bacterial Agents', 'Cross Infection', 'DNA, Bacterial', 'Humans', 'Japan', 'Klebsiella Infections', 'Klebsiella oxytoca', 'Klebsiella pneumoniae', 'Microbial Sensitivity Tests', 'Polymerase Chain Reaction', 'beta-Lactam Resistance', 'beta-Lactamases', 'beta-Lactams'] | 25,813,819 | [['D27.505.954.122.085'], ['C01.248', 'C23.550.291.875.500'], ['D13.444.308.212'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['C01.150.252.400.310.503'], ['B03.440.450.425.425.580', 'B03.660.250.150.400.580'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['E01.370.2... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Proteolytic processing of human growth hormone by multiple tissue kallikreins and regulation by the serine protease inhibitor Kazal-Type5 (SPINK5) protein. | BACKGROUND: Human growth hormone (hGH) is naturally present in numerous isoforms, some of which arise from proteolytic processing in both the pituitary and periphery. The nature of the enzymes that proteolytically cleave hGH and the regulation of this process are not fully understood. Our objective is to examine if mem... | ['Carrier Proteins', 'Enzyme Activation', 'Gene Expression Regulation, Enzymologic', 'Human Growth Hormone', 'Humans', 'Immunohistochemistry', 'Peptide Fragments', 'Proteinase Inhibitory Proteins, Secretory', 'RNA, Messenger', 'Serine Peptidase Inhibitor Kazal-Type 5', 'Tissue Kallikreins'] | 17,140,555 | [['D12.776.157'], ['G02.111.263', 'G03.328'], ['G05.308.320'], ['D06.472.699.631.525.425.875', 'D12.644.548.691.525.425.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Functional significance of delay-period activity of primate prefrontal neurons in relation to spatial working memory and reward/omission-of-reward expectancy. | The lateral prefrontal cortex (LPFC) is important in cognitive control. During the delay period of a working memory (WM) task, primate LPFC neurons show sustained activity that is related to retaining task-relevant cognitive information in WM. However, it has not yet been determined whether LPFC delay neurons are conce... | ['Animals', 'Behavior, Animal', 'Cognition', 'Macaca', 'Male', 'Memory, Short-Term', 'Prefrontal Cortex', 'Reaction Time', 'Reward', 'Space Perception'] | 16,034,567 | [['B01.050'], ['F01.145.113'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['F02.463.425.540.407'], ['A08.186.211.200.885.287.500.270.700'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F02.463.425.770.836'], ['F02.463.593.778']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inpatient nursing case management as a strategy for rural hospitals: a case study. | Increasingly, hospitals are facing the dual challenges of cost containment and a nursing shortage. These challenges are especially problematic for rural hospitals where nursing staff must be recruited and quality standards maintained within the financial limitations of lower DRG reimbursement rates when compared with u... | ['Documentation', 'Hospital Administration', 'Hospital Bed Capacity, under 100', 'Hospitals, Rural', 'Humans', 'Male', 'Nursing Assessment', 'Nursing Records', 'Nursing Service, Hospital', 'Patient Care Planning', 'Specialties, Nursing', 'United States'] | 10,304,470 | [['L01.453.245'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['N02.278.306.472.080'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.508.480'], ['E05.318.308.940.984', 'L01.399.250.900.984', 'N04.452.859.675', 'N05.715.360.300.715.550', 'N06.850.520.308.940.984'], ['N02.278.... | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Inhibition of hypochlorous acid-mediated reactions by desferrioxamine. Implications for the mechanism of cellular injury by neutrophils. | Inhibition of free radical mechanisms by desferrioxamine, an iron chelator, is often thought to be a good indicator of iron-catalyzed hydroxyl radical (OH.) production. The specificity of desferrioxamine is critical for such identification. This study was undertaken to determine whether desferrioxamine could prevent th... | ['Chloramines', 'Deferoxamine', 'Erythrocyte Membrane', 'Free Radicals', 'Hemoglobins', 'Hemolysis', 'Humans', 'Hypochlorous Acid', 'Iron', 'Molecular Structure', 'Neutrophils'] | 2,165,973 | [['D01.210.150', 'D02.092.348'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['D01.339', 'D02.389'], ['D12.776.124.400', 'D12.776.422.316.762'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.029.260.365', 'D01.21... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Blood-pressure-lowering effect of carvedilol vs nitrendipine in geriatric hypertensives. | Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension. The effects on blood pressure were measured (Riva Rocci) before medication and after 2 h with the patient in a lying and standing position after 4 weeks of ... | ['Adrenergic beta-Antagonists', 'Aged', 'Blood Pressure', 'Carbazoles', 'Carvedilol', 'Double-Blind Method', 'Female', 'Humans', 'Hypertension', 'Male', 'Nitrendipine', 'Posture', 'Propanolamines', 'Pulse', 'Randomized Controlled Trials as Topic'] | 1,974,510 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.633.100.473.144', 'D03.633.300.148'], ['D02.033.100.624.151', 'D02.033.755.624.151', 'D02.092.063.624.151', 'D03.633.100.473.144.125', 'D03.633.300.148.125'], ['E05.318.370.300', 'E05.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
On-chip thermopneumatic pressure for discrete drop pumping. | A class of "lab-on-a-chip" devices use external air pressure for pumping discrete drops in a microchannel network. External air connectors can be cumbersome and are real-estate intensive. We have developed an on-chip technique to generate pressures required for metering and pumping of nanoliter-volume discrete drops. T... | ['Air Pressure', 'Chemistry Techniques, Analytical', 'Manometry', 'Miniaturization'] | 11,338,598 | [['G16.500.750.274.100', 'N06.230.300.100.185.100'], ['E05.196'], ['E05.559'], ['J01.897.520']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. | To identify the potential involvement of tumor-suppressor gene inactivation during neoplastic development in B6C3F1 mice, genetic losses were determined from allelotypes of butadiene-induced lung and mammary adenocarcinomas. By using length polymorphisms in restriction fragments and simple sequence repeats, or "microsa... | ['Adenocarcinoma', 'Alleles', 'Animals', 'Base Sequence', 'Butadienes', 'Chromosome Mapping', 'DNA Primers', 'DNA, Neoplasm', 'Female', 'Genes, Retinoblastoma', 'Genes, Tumor Suppressor', 'Heterozygote', 'Humans', 'Lung Neoplasms', 'Male', 'Mammary Neoplasms, Experimental', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57... | 8,170,984 | [['C04.557.470.200.025'], ['G05.360.340.024.340.030'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D02.455.326.271.665.146.240'], ['E05.393.183'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.425'], ['G05.360.340.024.340.375.249.400', 'G05.360.340.024.340.415.4... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Conventional, diffusion, and permeability MR findings in ocular medulloepithelioma. | PURPOSE: To describe the neuroradiological features of intraocular medulloepithelioma.METHODS: We retrospectively analyzed the clinical, histopathological, and MRI data of five children with medulloepithelioma. In addition to conventional images, DWI was performed in four patients and mean ADC was calculated; this was ... | ['Brain Neoplasms', 'Child', 'Child, Preschool', 'Contrast Media', 'Diagnosis, Differential', 'Diffusion Magnetic Resonance Imaging', 'Echo-Planar Imaging', 'Female', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Infant', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Male', 'Meglumine',... | 30,232,518 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['M01.060.406.448'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['E01.370.350.825.500.150'], ['E01.370.350.825.500.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
An acute myocardial infarction case that survived an out-of-hospital cardiac arrest in which prominent ischemic J waves were documented. | We describe a case of a myocardial infarction, in which prominent ischemic J waves were documented during recurrent ventricular fibrillation attacks. The patient was referred to our hospital to treat an out-of hospital cardiac arrest. Although the 12-lead electrocardiogram obtained just after the first cardioversion di... | ['Ambulatory Care', 'Documentation', 'Electric Countershock', 'Electrocardiography', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Treatment Outcome'] | 20,723,080 | [['E02.760.106', 'N02.421.585.106'], ['L01.453.245'], ['E02.331.350'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Maternal intake of pesticide residues from fruits and vegetables in relation to fetal growth. | OBJECTIVES: To examine the associations of maternal intake of fruits and vegetables (FVs), considering pesticide residue levels, with fetal growth.METHODS: We studied 1777 mothers (1275 white, 502 non-white) and their infants from Project Viva, a prospective pre-birth cohort (1999-2002). We categorized FVs as containin... | ['Adult', 'Birth Weight', 'Cohort Studies', 'Dietary Exposure', 'Female', 'Fetal Development', 'Fruit', 'Humans', 'Infant, Newborn', 'Male', 'Maternal-Fetal Exchange', 'Mothers', 'Pesticide Residues', 'Pregnancy', 'Pregnancy Trimester, First', 'Pregnancy Trimester, Second', 'Prospective Studies', 'Vegetables'] | 30,029,096 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N06.850.460.350.040'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['A18.024.500... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phe... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Characterisation and classification of solid wastes coming from reductive acid leaching of low-grade manganiferous ore. | The present work was focused on the acid leaching process for manganese extraction in reducing environment to low-grade manganiferous ore that comes from Central Italy. The aim of this study was to establish optimum leaching operating conditions to reduce treatment costs of waste or, even better, to allow a waste valor... | ['Manganese', 'Microscopy, Electron, Scanning', 'Oxidation-Reduction', 'Particle Size', 'Refuse Disposal', 'Spectrophotometry, Atomic'] | 18,650,004 | [['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['G02.700', 'G03.295.531'], ['G02.712'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['E05.196.712.726.551', 'E05.196.867.826.551']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The hemodynamics of steal syndrome and its treatment. | A 61-year-old man developed steal syndrome after creation of a transposed basilic vein arteriovenous fistula (AVF) resulting in rest pain and ischemic ulcers in the fingertips. Our initial surgically created stenosis reduced the diameter by 32% and the area by 56%, and increased the radial artery pressure from 52 to 78... | ['Aged', 'Arteriovenous Shunt, Surgical', 'Brachial Artery', 'Hand', 'Hemodynamics', 'Humans', 'Ischemia', 'Male', 'Postoperative Complications', 'Renal Dialysis'] | 10,347,266 | [['M01.060.116.100'], ['E04.035.087', 'E04.100.814.868.249'], ['A07.015.114.139'], ['A01.378.800.667'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513'], ['C23.550.767'], ['E02.870.300', 'E02.912.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Maternal separation disturbs postnatal development of the medial prefrontal cortex and affects the number of neurons and glial cells in adolescent rats. | Adolescence is a period of extensive brain maturation. In particular, the regions of the medial prefrontal cortex (mPFC) undergo intense structural and functional refinement during adolescence. Disturbances in mPFC maturation have been implicated in the emergence of multiple psychopathologies during adolescence. One of... | ['Adolescent', 'Adolescent Behavior', 'Animals', 'Apoptosis', 'Behavior Rating Scale', 'Cell Count', 'Cell Survival', 'Female', 'Humans', 'Male', 'Maternal Deprivation', 'Neuroglia', 'Neurons', 'Prefrontal Cortex', 'Rats', 'Rats, Wistar', 'Stress, Psychological'] | 31,705,889 | [['M01.060.057'], ['F01.145.022'], ['B01.050'], ['G04.146.954.035'], ['F04.711.271'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.240'], ['A08.637', 'A11.650'], ['A08.675', 'A11.671'], ['A08.186.211.200.885.287.500... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Interaction of drug-carrier systems with targets--a study using atomic force microscopy. | To learn about the interaction between drug agents and nanoparticular carrier systems, the physical analytical methods of parelectric, electron spin and fluorescence spectroscopy have proven helpful tools to yield descriptive models of such complex systems. For a deeper understanding of drug absorption from body surfac... | ['Drug Carriers', 'Humidity', 'Indicators and Reagents', 'Lipids', 'Membranes, Artificial', 'Microscopy, Atomic Force', 'Peptides', 'Spectrometry, Fluorescence', 'Surface-Active Agents'] | 21,038,842 | [['D26.255.260', 'E02.319.300.380'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['D27.720.470.410'], ['D10'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D12.644'], ['E05.196.712.516.600.676', 'E05.196.867.72... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. | Green fluorescent protein (GFP) and variants have become powerful tools to study protein localization, interactions, and dynamics. We present here a mass spectrometry-based proteomics strategy to examine protein-protein interactions using anti-GFP single-chain antibody V(H)H in a combination with a novel stable isotopi... | ['Amino Acid Sequence', 'Animals', 'Blotting, Western', 'Cell Line', 'Chickens', 'Green Fluorescent Proteins', 'Intracellular Signaling Peptides and Proteins', 'Isotope Labeling', 'Molecular Sequence Data', 'Protein Binding', 'Protein Interaction Mapping', 'Protein-Tyrosine Kinases', 'Proteomics', 'Single-Chain Antibod... | 21,472,591 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D12.776.532.265'], ['D12.644.360', 'D12.776.476'], ['E05.522'], ['L01.453.245.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Treatment of severe aplastic anemia with sequential immunosuppression. | Forty-two patients with severe aplastic anemia (SAA) were treated with immunosuppressive therapy (IS) consisting of one or more courses of the following regimens: a) high dose bolus 6 methylprednisolone (BMPr); b) horse antilymphocytic globulin (HALG); c) rabbit ALG (RALG); d) ALG followed by the infusion of haploident... | ['Adolescent', 'Adult', 'Aged', 'Androgens', 'Anemia, Aplastic', 'Animals', 'Antilymphocyte Serum', 'Blood Transfusion', 'Bone Marrow Transplantation', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Combined Modality Therapy', 'Female', 'Horses', 'Humans', 'Immunosuppression', 'Italy', 'Leukocyte Count', 'Ma... | 6,357,828 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.399.472.161'], ['C15.378.071.085', 'C15.378.190.223.250'], ['B01.050'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114.573.203', 'D20.215.401.203'], ['E02.095.135'], ['E02.09... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Autosomal dominant hereditary spastic paraplegia: DHPLC-based mutation analysis of SPG4 reveals eleven novel mutations. | We set up a new denaturing high-performance liquid chromatography (DHPLC)-based protocol to screen patients with autosomal dominant hereditary spastic paraplegia (AD-HSP) for mutations in SPG4. Six patients had a complicated form and 49 a pure HSP phenotype. We also analyzed 19 unrelated patients presenting with an HSP... | ['Adenosine Triphosphatases', 'Adult', 'Amino Acid Sequence', 'Chromatography, High Pressure Liquid', 'Cohort Studies', 'DNA Mutational Analysis', 'Frameshift Mutation', 'Genes, Dominant', 'Genetic Testing', 'Humans', 'Italy', 'Middle Aged', 'Molecular Sequence Data', 'Mutation, Missense', 'Phenotype', 'Polymorphism, G... | 15,841,487 | [['D08.811.277.040.025'], ['M01.060.116'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.181.400.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.393.760.700.300'], ['G05.365.590.265'], ['G05.360.340.024.340.240', 'G05.420.320'], ['E01.370.225.562', 'E05.200.562', 'E05... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Potential Clinical Utility and Feasibility of Combined Left Atrial Appendage Closure and Positioning of Miniaturized Pacemaker Through a Single Right Femoral Vein Access. | This study assessed the clinical utility and feasibility of concomitant of combined left atrial appendage (LAA) closure and positioning of miniaturized pacemaker (Micra TPS). All consecutive patients who underwent VVI-PM implant from November 2015 to October 2016 were considered. VVI-PM implant was conducted either usi... | ['Aged', 'Aged, 80 and over', 'Atrial Appendage', 'Cardiac Catheterization', 'Cardiac Surgical Procedures', 'Echocardiography, Three-Dimensional', 'Echocardiography, Transesophageal', 'Feasibility Studies', 'Female', 'Femoral Vein', 'Follow-Up Studies', 'Humans', 'Male', 'Miniaturization', 'Pacemaker, Artificial', 'Ret... | 28,558,866 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.358.100'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E04.100.376', 'E04.928.220'], ['E01.370.350.130.750.230', 'E01.370.350.400.200', 'E01.370.350.850.220.230', 'E01.370.370.380.220.230'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement. | Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA-associated vasculitis (AAV), but renal outcomes are unknown. This is a post hoc analysis of patients enrolled in the Rituximab for ANCA-Associated Vasculitis (RAVE) Trial who had renal involve... | ['Adult', 'Aged', 'Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis', 'Antibodies, Monoclonal, Murine-Derived', 'Azathioprine', 'Cyclophosphamide', 'Female', 'Glomerulonephritis', 'Humans', 'Immunologic Factors', 'Kidney Function Tests', 'Male', 'Middle Aged', 'Recurrence', 'Remission Induction', 'Rituximab',... | 25,381,429 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.940.897.249', 'C20.111.193'], ['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['D02.886.759.111', 'D03.633.100.759.570.090', 'D13.570.900.111'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['C12.777.4... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Changes in the pulsatility index (Gosling) under drug action]. | The alterations in cerebral hemodynamics induced by drugs (papaverine, Cavinton, magnesium sulphate, piracetam, histamine) in a series of 152 patients compared with a control series were analysed. The response of each basal cerebral artery to these drugs is assessed through the pulsatility index value. | ['Blood Flow Velocity', 'Cerebrovascular Circulation', 'Female', 'Histamine', 'Humans', 'Ischemic Attack, Transient', 'Magnesium Sulfate', 'Male', 'Middle Aged', 'Papaverine', 'Piracetam', 'Pulsatile Flow', 'Rheology', 'Ultrasonography', 'Vinca Alkaloids'] | 2,682,899 | [['E01.370.370.130', 'G09.330.380.630.080'], ['G09.330.100.159'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['D01.524.550', 'D01.875.800.800.850.500'], ['M01.060.116.630'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[DNA extraction and identification of Trichophyton rubrum by real-time polymerase chain reaction from direct nail scraping specimens of patients with onycomycosis]. | Trichophyton rubrum is the most frequently encountered dermatophyte species causing onichomycosis. The routine diagnosis of dermatophytes depends on the direct microscopic examination (DME) and culture methods, however due to the phenotypic identification problems related to those agents, the molecular methods come int... | ['DNA, Fungal', 'Female', 'Humans', 'Male', 'Nails', 'Onychomycosis', 'Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Tinea', 'Trichophyton'] | 21,341,169 | [['D13.444.308.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A17.600'], ['C01.150.703.302.720.550', 'C01.800.200.720.550', 'C17.800.529.550', 'C17.800.838.208.883.458'], ['E05.393.620.500'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. | The effects of Bax (full-length, FL, and C-terminal truncated, DeltaC) on respiration rate, membrane potential, MgATPase activity and kinetics of regulation of respiration were studied in isolated rat heart mitochondria and permeabilized cardiomyocytes. The results showed that while both Bax-FL and Bax-DeltaC permeabil... | ['Adenosine Diphosphate', 'Animals', 'Ca(2+) Mg(2+)-ATPase', 'Cell Fractionation', 'Cell Respiration', 'Cytochrome c Group', 'Intracellular Membranes', 'Membrane Potentials', 'Mitochondria, Heart', 'Myocytes, Cardiac', 'Oxidation-Reduction', 'Oxygen', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-2', 'Rats'... | 12,460,673 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['B01.050'], ['D08.811.277.040.025.095'], ['E05.242.251'], ['G03.197', 'G04.270'], ['D08.244.286', 'D12.776.422.220.286'], ['A11.284.149.450', 'A11.284.835.514'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A11.284.430.214.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Excess Hispanic fetal-infant mortality in a midwestern community. | OBJECTIVE: We assessed excess fetal-infant mortality for Hispanic, non-Hispanic white, and non-Hispanic black populations in five contiguous counties of Missouri and Kansas.METHODS: We conducted a perinatal periods of risk (PPOR) assessment of fetal-infant mortality using electronic linked birth-death record files from... | ['African Americans', 'European Continental Ancestry Group', 'Female', 'Fetal Mortality', 'Hispanic Americans', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature', 'Kansas', 'Maternal Welfare', 'Medical Record Linkage', 'Missouri', 'Perinatal Care', 'Pregnancy'] | 19,753,949 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.686.508.400'], ['E05.318.308.985.550.362', 'N01.224.935.698.300', 'N06.850.505.400.975.550.362', 'N06.850.520.308.985.550.362'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Simultaneous determination of NNK and its seven metabolites in rabbit blood by hydrophilic interaction liquid chromatography-tandem mass spectrometry. | A hydrophilic interaction liquid chromatographic-tandem mass spectrometric (HILIC-MS-MS) method for investigation of the in vivo metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen, in rabbit blood has been developed and validated. This method achieved excellent repeatability and acc... | ['Animals', 'Biotransformation', 'Carcinogens', 'Chromatography, Liquid', 'Cyclic N-Oxides', 'Hydrophobic and Hydrophilic Interactions', 'Hydroxylation', 'Limit of Detection', 'Male', 'Nitrosamines', 'Pyridines', 'Rabbits', 'Reproducibility of Results', 'Tandem Mass Spectrometry'] | 23,307,122 | [['B01.050'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D27.888.569.100'], ['E05.196.181.400'], ['D03.661.243'], ['G02.409'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D02.654.442'], ['D03.383.725'], ['B01.050.150.900.649.313.968.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo. | Cytosine deaminase is used in combination with 5-fluorocytosine as an enzyme-prodrug combination for targeted genetic cancer treatment. This approach is limited by inefficient gene delivery and poor prodrug conversion activities. Previously, we reported individual point mutations within the substrate binding pocket of ... | ['Animals', 'Antimetabolites, Antineoplastic', 'Apoptosis', 'Combined Modality Therapy', 'Cytosine Deaminase', 'Escherichia coli Proteins', 'Female', 'Flucytosine', 'Genetic Therapy', 'HCT116 Cells', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Models, Molecular', 'Mutant Proteins', 'Neoplasms', 'Prodrugs', ... | 19,487,291 | [['B01.050'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['G04.146.954.035'], ['E02.186'], ['D08.811.277.151.486.625'], ['D12.776.097.275'], ['D03.383.742.698.421.431'], ['E02.095.301', 'E05.393.420.301'], ['A11.251.210.190.380', 'A11.251.860.180.380'], ['B01.050.150.900.649.313.988.400.112.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extracerebellar MRI-lesions in ataxia telangiectasia go along with deficiency of the GH/IGF-1 axis, markedly reduced body weight, high ataxia scores and advanced age. | Ataxia telangiectasia (AT) is a rare autosomal recessive disorder characterized by progressive ataxia, neurodegeneration, immunodeficiency, and cancer predisposition. Pathoanatomical studies reported a degeneration of cerebellar Purkinje cells as the striking feature of the disease. Although recent studies suggested th... | ['Adolescent', 'Adult', 'Ataxia Telangiectasia', 'Basal Ganglia', 'Body Mass Index', 'Body Weight', 'Cerebellum', 'Child', 'Disability Evaluation', 'Female', 'Growth Hormone', 'Humans', 'Insulin-Like Growth Factor I', 'Magnetic Resonance Imaging', 'Male', 'Neurologic Examination', 'Spinal Cord', 'Young Adult'] | 19,898,915 | [['M01.060.057'], ['M01.060.116'], ['C10.228.140.252.190.530.060', 'C10.562.100', 'C10.597.350.090.500.530.060', 'C14.907.823.213', 'C16.320.080', 'C16.320.798.250', 'C18.452.284.060', 'C20.673.795.250'], ['A08.186.211.200.885.287.249'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Acute Mediastinitis]. | Acute mediastinitis is an infectious disease of differentiated etiology, characterized by a rapid and severe course. Causes, diagnosis, and treatment of acute mediastinitis was described. Our experience of descending necrotizing mediastinitis were demonstrated with chest X-ray, computed tomography (CT), and operative f... | ['Acute Disease', 'Aged, 80 and over', 'Humans', 'Male', 'Mediastinitis', 'Postoperative Complications', 'Thoracic Surgical Procedures', 'Tomography, X-Ray Computed'] | 26,197,914 | [['C23.550.291.125'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.846.187.790'], ['C23.550.767'], ['E04.928'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy. | ASS234 is a new multitarget molecule with multiple neuroprotective actions that significantly elevate mRNA levels of NRF2 and HSF1 transcriptional factors and of HSP105, HSP90AB1, HSPA1A, HSPA1B, HSPA5, HSPA8, HSPA9, HSP60, DNAJA1, DNAJB1, DNAJB6, DNAJC3, DNAJC5, DNAJC6, HSPB1, HSPB2, HSPB5, HSPB6, HSPB8, and HSP10 hea... | ['Antioxidants', 'Cell Line, Tumor', 'Heat-Shock Proteins', 'Humans', 'Indoles', 'Neurodegenerative Diseases', 'Neuroprotective Agents', 'Piperidines', 'Up-Regulation'] | 30,133,257 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['C10.574'], ['D27.505.696.706.548', 'D27.505.954.427.575'], ['D03.383.621'], ['G02.111.905', 'G05.308.850', 'G07.690.773.998... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Auxiliary liver transplantation with arterialization of the portal vein for acute hepatic failure. | Six adult patients suffering from acute hepatic failure and with a high urgent status underwent heterotopic auxiliary liver transplantation. In four of these patients, the portal vein of the liver graft was arterialized in order to leave the native liver and the liver hilum untouched and to be able to place the liver g... | ['Acute Disease', 'Adolescent', 'Adult', 'Hepatic Encephalopathy', 'Humans', 'Liver Transplantation', 'Middle Aged', 'Portal Vein'] | 9,704,389 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.060.116.630'], ['A07.015.908.670.567']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effect of random or sequential presentation of targets during robot-assisted therapy on children. | BACKGROUND: Robot assisted upper extremity therapy has been shown to be effective in adult stroke patients and in children with cerebral palsy (CP) and other acquired brain injuries (ABI). The patient's active involvement is a factor in its efficacy. However, this demands focused attention during training sessions, whi... | ['Adolescent', 'Attention', 'Brain Injuries', 'Cerebral Palsy', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Robotics', 'Upper Extremity'] | 23,949,025 | [['M01.060.057'], ['F02.830.104.214'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C10.228.140.140.254'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.723.729'], ['H01.671.293.643', 'J01.897.104.834', 'L01.224.050.375.630'], ['A01.378.800']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. | The regulation of intracellular pools of Ca2+ was investigated in an interleukin-3 (IL-3)-dependent hematopoietic cell line 32D that undergoes programmed cell death ("apoptosis") when deprived of lymphokine. Comparisons were made with 32D cells that had been stably transfected with a bcl-2 expression plasmid that encod... | ['Animals', 'Apoptosis', 'Calcium', 'Cell Line', 'Chelating Agents', 'Hematopoietic Stem Cells', 'Interleukin-3', 'Kinetics', 'Mice', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-2', 'Terpenes', 'Thapsigargin'] | 8,454,620 | [['B01.050'], ['G04.146.954.035'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210'], ['D27.505.519.914.500', 'D27.720.832.500'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['D12.644.276.374.410.240.400', 'D12.644.276.374.465.032', 'D12.776.395.240.400', 'D12.776.467.374.410.240.400', 'D12.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mesoporous calcium silicate for controlled release of bovine serum albumin protein. | The purpose of this study is to synthesize mesoporous calcium silicate (CS or wollastonite, CaSiO(3)) and evaluate its possible application in protein/drug delivery. First, calcium silicate was synthesized by wet chemical method and then mesoporosity was created by acid modification of the synthesized CS particle using... | ['Acids', 'Adsorption', 'Animals', 'Biocompatible Materials', 'Calcium Compounds', 'Cattle', 'Cell Line', 'Delayed-Action Preparations', 'Drug Carriers', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Muramidase', 'Nitrogen'... | 19,249,262 | [['D01.029'], ['G01.030', 'G02.020'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D01.146'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210'], ['D26.255.210', 'E02.319.300.253'], ['D26.255.260', 'E02.319.300.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation. | The present study was conducted to determine if the cryopreservation of immature human oocytes has a deleterious effect on the meiotic spindle following maturation in vitro. Oocytes were obtained in excess from in-vitro fertilization patients and divided into four groups. Groups 1 (n = 98) and 2 (n = 80) consisted of i... | ['Cell Survival', 'Cells, Cultured', 'Cellular Senescence', 'Chromosomes', 'Cryopreservation', 'Fluorescent Antibody Technique', 'Humans', 'Oocytes', 'Spindle Apparatus'] | 8,582,988 | [['G04.346'], ['A11.251'], ['G04.043'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.2... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of local application of basic fibroblast growth factor on ligament healing in rabbits. | OBJECTIVE: The effect of basic fibroblast growth factor (bFGF) on healing of a 4-mm defect in the medial collateral ligament of rabbits was studied.METHODS: Fibrin gel containing 0 (vehicle only), 0.1, 1, or 10 micrograms of recombinant human bFGF was applied to the defect during the surgical procedure. Controls did no... | ['Animals', 'Fibroblast Growth Factor 2', 'Fibroblasts', 'Humans', 'In Situ Hybridization', 'Male', 'Medial Collateral Ligament, Knee', 'Procollagen', 'RNA, Messenger', 'Rabbits', 'Recombinant Proteins', 'Wound Healing'] | 9,670,333 | [['B01.050'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['A02.513.514.162.600', 'A02.835.583... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
X-ray repair cross-complementing group 1 Arg399Gln gene polymorphism and susceptibility to colorectal cancer:a meta-analysis. | X-ray repair cross-complementing group 1 (XRCC1), a DNA repair enzyme, plays a crucial role in the base excision repair by generating a single nucleotide repair patch. It has been demonstrated that the XRCC1 Arg399Gln gene polymorphism was associated with variations in XRCC1 enzyme activity. The aim of this study was t... | ['Asian Continental Ancestry Group', 'Case-Control Studies', 'Colorectal Neoplasms', 'DNA Repair', 'DNA-Binding Proteins', 'European Continental Ancestry Group', 'Genetic Predisposition to Disease', 'Humans', 'Polymorphism, Single Nucleotide', 'X-ray Repair Cross Complementing Protein 1'] | 23,188,703 | [['M01.686.508.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.111.222', 'G05.219'], ['D12.776.260'], ['M01.686.508.400'], ['C23.550... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of physical exercise and gender on acetylcholinesterase and butyrylcholinesterase activity in human blood samples. | The determination of cholinesterase activity in plasma and erythrocytes serves as a useful and sensitive biomarker of exposure to organophosphorus and carbamate pesticides. However, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity may be influenced by factors such as age, gender, drugs, and physic... | ['Acetylcholinesterase', 'Adult', 'Butyrylcholinesterase', 'Erythrocytes', 'Exercise', 'Female', 'Humans', 'Male', 'Sex Characteristics', 'Surveys and Questionnaires', 'Young Adult'] | 22,149,082 | [['D08.811.277.352.100.170.176'], ['M01.060.116'], ['D08.811.277.352.100.170.250'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.815'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['M01.060.116.81... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin. | The human 20S proteasome inhibitor scytonemide A (1), a macrocyclic imine originally isolated from the cyanobacterium Scytonema hofmanni, was synthesized via a biomimetic solid-phase peptide synthesis (SPPS) approach employing the Weinreb AM resin. Utilizing this approach, cyclization of the protected heptapeptide via ... | ['Amides', 'Cyclization', 'Depsipeptides', 'Humans', 'Proteasome Inhibitors', 'Resins, Plant', 'Solid-Phase Synthesis Techniques'] | 29,400,964 | [['D02.065'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D04.345.566.297', 'D12.644.641.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.389.745.705'], ['D05.750.078.840', 'D20.215.721.500'], ['E05.197.500', 'J01.897.836.249.500']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The UCSC Genome Browser database: update 2011. | The University of California, Santa Cruz Genome Browser (http://genome.ucsc.edu) offers online access to a database of genomic sequence and annotation data for a wide variety of organisms. The Browser also has many tools for visualizing, comparing and analyzing both publicly available and user-generated genomic data se... | ['Animals', 'Databases, Genetic', 'Disease', 'Genes', 'Genome, Human', 'Genomics', 'Hominidae', 'Humans', 'Internet', 'Molecular Sequence Annotation', 'Phenotype', 'RNA Editing', 'Software'] | 20,959,295 | [['B01.050'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['C23.550.288'], ['G05.360.340.024.340'], ['G05.360.340.350'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['E05.393.760.47... | ['Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Enhanced protein breakdown after eccentric exercise in young and older men. | The effects of eccentric exercise on whole body protein metabolism were compared in five young untrained [age 24 +/- 1 yr, maximal O2 uptake (VO2max) = 49 +/- 6 ml.kg-1.min-1] and five older untrained men (age 61 +/- 1 yr, VO2max = 34 +/- 2 ml.kg-1.min-1). They performed 45 min of eccentric exercise on a cycle ergomete... | ['Adult', 'Aging', 'Calorimetry', 'Carbon Dioxide', 'Creatine Kinase', 'Exercise', 'Humans', 'Kinetics', 'Leucine', 'Male', 'Methylhistidines', 'Middle Aged', 'Nitrogen', 'Oxygen Consumption', 'Proteins'] | 1,938,741 | [['M01.060.116'], ['G07.345.124'], ['E05.196.131'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D08.811.913.696.640.150'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D12.125.070.637', 'D12.125.142.441'], ['D12.125.072.329.539'], ['M01.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Response shift in quality of life after endoscopic sinus surgery for chronic rhinosinusitis. | IMPORTANCE: Patient-reported measures are designed to detect a true change in outcome, but they are also subject to change from biases inherent to self-reporting: changing internal standards, changing priorities, and changing interpretations of a given instrument. These biases are collectively known as "response shifts... | ['Adult', 'Aged', 'Chronic Disease', 'Endoscopy', 'Factor Analysis, Statistical', 'Female', 'Health Status Indicators', 'Humans', 'Male', 'Middle Aged', 'Otorhinolaryngologic Surgical Procedures', 'Outcome Assessment, Health Care', 'Postoperative Period', 'Prospective Studies', 'Quality of Life', 'Rhinitis', 'Self Repo... | 25,074,504 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['E01.370.388.250', 'E04.502.250'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Cytogenetic studies of preinvasive lesions and invasive carcinomas' of the cervix uteri. III. Survey and interpretation of the results reported in the literature. | Summary. Cytogenetic studies were performed of 54 preinvasive carcinomas and invasive squamous cervix carcinomas altogether. The chromosome number could be determined in 9 dysplasias, 25 carcinomas in situ, 4 carcinomas in situ with micro-invasion and 16 invasive squamous carcinomas (at least clinical stage Ib). It was... | ['Carcinoma in Situ', 'Carcinoma, Squamous Cell', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Chromosome Aberrations', 'Chromosome Deletion', 'Female', 'Humans', 'Karyotyping', 'Ploidies', 'Precancerous Conditions', 'Uterine Cervical Neoplasms'] | 1,243,614 | [['C04.557.470.200.240'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['C23.550.210', 'G05.365.590.175'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], [... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Overzealous resuscitation of an extremely malnourished patient with nutritional cardiomyopathy. | Overzealous resuscitation of the severely malnourished patient may be associated with life-threatening complications. A variety of electrolyte, hemodynamic, septic, and nutritional derangements may result in sudden decompensation and even death. We present a case that dramatically illustrates these complications and fo... | ['Adult', 'Alcoholism', 'Cardiomyopathy, Dilated', 'Dehydration', 'Female', 'Humans', 'Protein-Energy Malnutrition', 'Pulmonary Edema', 'Resuscitation'] | 2,127,840 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['C18.452.950.179', 'C23.550.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.521.500.708.626'], ['C08.381.742'], ['E02.365.647']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Classifying severity of abdominal contour deformities after weight loss to aid in patient counseling: a review of 1006 cases. | BACKGROUND: Abdominal contour deformities after massive weight loss are highly variable, ranging from a mild upper protuberance to multiple rolls. Correction of these deformities is challenging and may require advanced surgical techniques. Evaluating the incidence of patients presenting with various abdominal deformiti... | ['Abdomen', 'Abdominoplasty', 'Adult', 'Bariatric Surgery', 'Counseling', 'Female', 'Humans', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Postoperative Complications', 'Severity of Illness Index', 'Weight Loss'] | 25,415,111 | [['A01.923.047'], ['E02.218.042', 'E04.680.025'], ['M01.060.116'], ['E02.650.500.062', 'E04.062'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.6... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Histo- and cytophysiology of the lactating mammary gland of the African elephant (Loxodonta africana). | The lactating mammary gland of the African elephant (Loxodonta africana) has been studied with a panel of morphological techniques focusing on (1) the functional changes during the secretory process, (2) proliferative process [by application of proliferating cell nuclear antigen (PCNA) immunohistochemistry] and apoptot... | ['Animals', 'Elephants', 'Female', 'Freeze Etching', 'Freeze Fracturing', 'Immunohistochemistry', 'Lactation', 'Mammary Glands, Animal', 'Microscopy, Electron', 'Milk', 'Nipples'] | 9,799,466 | [['B01.050'], ['B01.050.150.900.649.833.249'], ['E01.370.225.500.620.620.260.400', 'E01.370.225.750.600.620.260.400', 'E05.200.500.620.620.260.400', 'E05.200.750.600.620.260.400'], ['E01.370.225.500.620.620.260', 'E01.370.225.750.600.620.260', 'E05.200.500.620.620.260', 'E05.200.750.600.620.260'], ['E01.370.225.500.607... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. | Cytosolic inflammasome complexes mediated by a pattern recognition receptor (PRR) defend against pathogen infection by activating caspase 1. Pyrin, a candidate PRR, can bind to the inflammasome adaptor ASC to form a caspase 1-activating complex. Mutations in the Pyrin-encoding gene, MEFV, cause a human autoinflammatory... | ['Animals', 'Bacterial Proteins', 'Bacterial Toxins', 'Burkholderia cenocepacia', 'Caspase 1', 'Cell Line', 'Clostridioides difficile', 'Cytoskeletal Proteins', 'Humans', 'Immunity, Innate', 'Inflammasomes', 'Mice', 'Mice, Inbred Strains', 'Mutation', 'Protein Binding', 'Pyrin', 'Receptors, Pattern Recognition', 'U937 ... | 24,919,149 | [['B01.050'], ['D12.776.097'], ['D23.946.123'], ['B03.660.075.090.688.100.110.490'], ['D08.811.277.656.262.500.126.550.100', 'D08.811.277.656.300.200.126.550.100', 'D12.644.360.075.405.550.100', 'D12.776.476.075.405.550.100'], ['A11.251.210'], ['B03.353.625.657.500'], ['D12.776.220'], ['B01.050.150.900.649.313.988.400.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Epidemiological surveillance of diphtheria infection in the territory of the Azerbaijan SSR]. | A complex of measures carried out with a view of effecting the epidemiological surveillance of diphtheria infection has made it possible to study the level and intensity of immunity to diphtheria and tetanus, determined in the passive hemagglutination test, in the child and adult population and to reveal groups, least ... | ['Adolescent', 'Adult', 'Age Factors', 'Antibodies, Bacterial', 'Azerbaijan', 'Carrier State', 'Child', 'Corynebacterium diphtheriae', 'Diphtheria', 'Diphtheria Toxin', 'Humans', 'Immunity', 'Population Surveillance', 'Risk Factors', 'Serotyping', 'Tetanus Toxin'] | 2,966,528 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['Z01.542.900.120'], ['N06.850.520.169'], ['M01.060.406'], ['B03.510.024.250.150', 'B03.510.460.400.400.200.150'], ['C01.150.252.410.040.246.388'], ['... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acellularization of embryoid bodies via physical disruption methods. | Embryonic stem cells (ESCs) are capable of differentiating into all somatic cell types and have therefore attracted significant interest for use in tissue repair and regeneration therapies. Transplanted ESCs can not only integrate into compromised tissues, but can also stimulate endogenous regeneration via secreted fac... | ['Animals', 'Cell Adhesion', 'Cell Culture Techniques', 'Cell Shape', 'Embryo, Mammalian', 'Embryonic Stem Cells', 'Extracellular Matrix', 'Fibroblasts', 'Mice', 'NIH 3T3 Cells'] | 19,042,017 | [['B01.050'], ['G04.022'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.320'], ['A16.254'], ['A11.872.700.250'], ['A11.284.295.310'], ['A11.329.228'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.251.210.100.550', 'A11.329.228.100.550']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Voiding dysfunction in pediatric patients. | The goals of this study were to describe the pattern of voiding disorders in children in our community, to describe clinical criteria for making the specific diagnoses, and to comment on management. The medical records of 226 children referred because of voiding dysfunction or urinary tract infections (UTI) were evalua... | ['Age Distribution', 'Child', 'Child, Preschool', 'Cohort Studies', 'Enuresis', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Male', 'Oliguria', 'Polyuria', 'Risk Assessment', 'Sex Distribution', 'Urinary Incontinence', 'Urinary Retention', 'Urinary Tract Infections', 'Urination Disorders', 'Urodynamics'] | 12,635,981 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C12.777.934.284', 'C13.351.968.934.252', 'F01.145.126.856', 'F03.388.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.5... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Estimating the null distribution to adjust observed confidence levels for genome-scale screening. | In a novel approach to the multiple testing problem, Efron (2004, Journal of the American Statistical Association 99, 96-104; 2007a Journal of the American Statistical Association 102, 93-103; 2007b, Annals of Statistics 35, 1351-1377) formulated estimators of the distribution of test statistics or nominal p-values und... | ['Genomics', 'Models, Statistical', 'Oligonucleotide Array Sequence Analysis', 'Statistical Distributions'] | 20,880,014 | [['H01.158.273.180.350', 'H01.158.273.343.350'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['E05.318.740.994', 'G17.820', 'N05.715.360.750.750', 'N06.850.520.830.994']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
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