Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Effect of short- and long-term stress on plasma calcium and calcitonin in the rat. | Although hypocalcemia has been observed during stress, the cause(s) is still unknown. The effect of short- and long-term restraint stress on calcitonin (CT) secretion and on plasma calcium (Ca), inorganic phosphate (P), total protein (TP), and corticosterone (CORT) were investigated in the male and female Sprague-Dawle... | ['Animals', 'Calcitonin', 'Calcium', 'Corticosterone', 'Female', 'Male', 'Phosphates', 'Rats', 'Rats, Inbred Strains', 'Restraint, Physical', 'Sex Characteristics', 'Stress, Physiological', 'Time Factors'] | 3,817,748 | [['B01.050'], ['D06.472.699.150', 'D06.472.931.052', 'D12.644.400.095', 'D12.644.548.150', 'D12.776.631.650.095'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A seat for premature infants. | Premature infants may benefit from short periods of supported sitting for position change, to facilitate the development of head control, to help with feeding and respiration, and to decrease intracranial pressure. This paper describes a seat designed for premature infants weighing 900 g to 2,000 g and made from thermo... | ['Humans', 'Infant Care', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Intensive Care Units, Neonatal', 'Posture'] | 3,688,121 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.088.120'], ['M01.060.703.520'], ['C16.614.521'], ['N02.278.388.493.390.380'], ['G11.427.695']] | ['Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Commutability of a Whole-Blood External Quality Assessment Material for Point-of-Care C-Reactive Protein, Glucose, and Hemoglobin Testing. | BACKGROUND: The optimal situation in external quality assessment (EQA) is to use commutable materials. No previous study has examined the commutability of a whole-blood material for point-of-care (POC) testing. The aim of this study was to determine the commutability of the Norwegian Quality Improvement of Laboratory E... | ['Blood Glucose', 'C-Reactive Protein', 'Case-Control Studies', 'Diabetes Mellitus', 'Hemoglobins', 'Humans', 'Point-of-Care Systems', 'Quality Control'] | 30,858,160 | [['D09.947.875.359.448.500'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C18.452.394.750', 'C19.246'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.442.452.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Chronic intracerebroventricular infusions of endothelin elevate arterial pressure in rats. | We investigated the effects of intracerebroventricular infusions of endothelin on cardiovascular and endocrinological responses using conscious, unrestrained rats. Chronic intracerebroventricular infusions of endothelin, 10 pmol/h for 7 days, elevated arterial pressure significantly on days 5, 6 and 7 of the infusion, ... | ['Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Brain', 'Endothelins', 'Epinephrine', 'Heart Rate', 'Infusions, Intravenous', 'Injections, Intraventricular', 'Male', 'Norepinephrine', 'Rats', 'Rats, Inbred Strains', 'Receptors, Cell Surface', 'Receptors, Endothelin', 'Sympathetic Nervous System'] | 1,848,263 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A08.186.211'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Field studies on different control schemes for hookworm infection]. | Three different control schemes including selective chemotherapy, a combination of selective chemotherapy and management of fecal disposal and mass treatment with mebendazole-medicated salt were implemented for the control of hookworm infection in Luwo Town and Taiping Village, Wuming County, Guangxi Zhuang Autonomous ... | ['Ancylostomiasis', 'Animals', 'Bephenium Compounds', 'Humans', 'Levamisole', 'Mebendazole', 'Necator americanus', 'Necatoriasis', 'Pyrantel Pamoate'] | 8,168,249 | [['C01.610.335.508.700.775.455.154'], ['B01.050'], ['D02.092.877.096.166', 'D02.675.276.102'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.675.346', 'D03.383.129.308.480', 'D03.383.129.708.346'], ['D02.241.081.251.415', 'D03.633.100.103.600'], ['B01.050.500.500.294.400.968.100.550.100'], ['C01.610.335.50... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Amino Acid Prevalence of HIV-1 pol | The presence of many highly unusual HIV-1 mutations at a minority variant threshold by next-generation sequence (NGS) may indicate that a high proportion of variants at or just above the threshold represent PCR errors. The validity of this hypothesis depends on the concept that highly unusual mutations detected by popu... | ['APOBEC Deaminases', 'Amino Acid Sequence', 'Amino Acid Substitution', 'Base Sequence', 'Codon, Terminator', 'Databases, Genetic', 'Datasets as Topic', 'Genes, pol', 'Genetic Variation', 'HIV Infections', 'HIV-1', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Mutation, Missense', 'Prevalence', 'RNA, Viral', 'Rep... | 31,317,771 | [['D08.811.277.151.486.250.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.735.544.355.250', 'G05.360.335.355.250', 'G05.360.340.024.340.137.190.250'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Tillaux fracture of the ankle in an adult: a rare injury. | The Tillaux fracture of the ankle is an external rotation ankle injury resulting in an avulsion fracture of the anterolateral tibial plafond. This injury is known to occur in adolescents, although it has rarely been reported in adults. We report a case of a Tillaux fracture in an adult. A brief description of the histo... | ['Adult', 'Ankle Fractures', 'Ankle Joint', 'Humans', 'Male', 'Tibial Fractures', 'Tomography, X-Ray Computed'] | 25,128,312 | [['M01.060.116'], ['C26.404.014'], ['A02.835.583.378.062'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.404.875', 'C26.558.857'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama. | The rate and severity of Clostridium difficile infection (CDI) have been linked to the emergence and spread of the hypervirulent toxigenic strain NAP1/027. This strain has been responsible for large outbreaks in healthcare facilities in North America and Europe and most recently in Latin America. This is the first repo... | ['Aged', 'Bacterial Toxins', 'Clostridioides difficile', 'Clostridium Infections', 'Cross Infection', 'Drug Resistance, Bacterial', 'Epidemics', 'Genotype', 'Humans', 'Panama'] | 24,287,669 | [['M01.060.116.100'], ['D23.946.123'], ['B03.353.625.657.500'], ['C01.150.252.410.222'], ['C01.248', 'C23.550.291.875.500'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['N06.850.290.200'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.169.772']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Large-scale assessment of activity landscape feature probabilities of bioactive compounds. | Activity landscape representations integrate pairwise compound similarity and potency relationships and provide direct access to characteristic structure-activity relationship features in compound data sets. Because pairwise compound comparisons provide the foundation of activity landscape design, the assessment of spe... | ['Drug Discovery', 'Informatics', 'Probability', 'Structure-Activity Relationship'] | 24,410,456 | [['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['L01.313'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['G02.111.830', 'G07.690.773.997']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Harvard Pilgrim Health Care--leading the competition and growing. | New England's largest HMO wants to be even bigger. The product of a 1995 merger, Harvard Pilgrim is seeking ways to reduce per-member-per-month costs, creating new health plans with greater choice of providers, changing physician relationships from staff-model to group practice and looking at other merger opportunities... | ['Cost Control', 'Economic Competition', 'Health Facility Merger', 'Health Maintenance Organizations', 'Marketing of Health Services', 'Models, Organizational', 'New England'] | 10,167,539 | [['N03.219.151.160'], ['N03.219.188'], ['N02.278.235'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['J01.219.687.550', 'N03.219.463.548', 'N05.300.430.500'], ['E05.599.670', 'N04.452.534'], ['Z01.107.567.875.550']] | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
How should I treat an unusual referral for heart transplantation? | BACKGROUND: A 55 years old man was referred for cardiac transplantation because of intractable angina and fatigue.INVESTIGATION: Physical examination, laboratory test, echocardiography, exercise ECG, MRI and coronary arteriography.DIAGNOSIS: Multiple coronary artery fistulae.MANAGEMENT: Beta-blockers, angiotensin-conve... | ['Adrenergic beta-Antagonists', 'Angina Pectoris', 'Angiotensin-Converting Enzyme Inhibitors', 'Coronary Angiography', 'Coronary Artery Disease', 'Defibrillators, Implantable', 'Echocardiography, Doppler, Color', 'Electric Countershock', 'Electrocardiography', 'Exercise Test', 'Exercise Tolerance', 'Fatigue', 'Heart Tr... | 20,142,204 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['D27.505.519.389.745.085'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.2... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption. | Mice and rats are commonly used to investigate in vivo nasal drug absorption, yet their small nasal cavities limit their use for in vitro investigations. Bovine tissue explants have been used to investigate drug transport through the nasal respiratory and olfactory mucosae, yet limited information is available regardin... | ['Administration, Intranasal', 'Animals', 'Biological Transport', 'Cattle', 'Gene Expression Profiling', 'Humans', 'Mice', 'Multidrug Resistance-Associated Proteins', 'Nasal Absorption', 'Nasal Mucosa', 'Nucleoside Transport Proteins', 'Oligonucleotide Array Sequence Analysis', 'Organic Cation Transport Proteins', 'Rat... | 26,106,909 | [['E02.319.267.120.655.500'], ['B01.050'], ['G03.143'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.157.530.100.304', 'D12.776.157.530.450.074.500.500.500', 'D12.776.543.585.100.304', 'D12.776.543.585.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Pathogenesis of acute destructive lung processes of staphylococcal etiology]. | Destructive processes in the lungs caused by staphylococci (SDL) were found to result in changes to the lipid metabolism in the lung parenchyma and organism of the patient which seemed to bring about disturbances in the pulmonary surfactant. Complex therapy made it possible to decrease the mortality rate in a group of ... | ['Acute Disease', 'Adult', 'Cytotoxicity, Immunologic', 'Humans', 'Lung', 'Lung Diseases', 'Pulmonary Surfactants', 'Staphylococcal Infections', 'Staphylococcus'] | 6,894,507 | [['C23.550.291.125'], ['M01.060.116'], ['G12.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381'], ['D27.505.954.796.600'], ['C01.150.252.410.868'], ['B03.300.390.400.800.750', 'B03.353.500.750.750', 'B03.510.100.750.750', 'B03.510.400.790.750']] | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells. | We investigated the effect of an ABCE1-silencing gene on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells. We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer... | ['ATP-Binding Cassette Transporters', 'Apoptosis', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Flow Cytometry', 'Gene Expression Regulation, Neoplastic', 'Gene Silencing', 'Humans', 'Neoplasm Invasiveness', 'RNA Interference', 'Thyroid Neoplasms', 'Transfection'] | 26,600,528 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic Variation among Human Isolates of Uninucleated Cyst-Producing Entamoeba Species. | Twelve human infections with Entamoeba spp. producing uninucleated cysts were studied. DNA was extracted from infected feces and used to amplify part of the ameba small-subunit rRNA gene. Sequence analysis identified four distinct types of Entamoeba, all of which are related to Entamoeba polecki and E. chattoni and two... | ['Animals', 'Base Sequence', 'DNA, Protozoan', 'Entamoeba', 'Entamoebiasis', 'Feces', 'Genes, rRNA', 'Genetic Variation', 'Humans', 'Phylogeny', 'Sequence Alignment', 'Sequence Analysis, DNA'] | 11,283,106 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.442'], ['B01.046.500.100.700.335'], ['C01.610.752.049.407'], ['A12.459'], ['G05.360.340.024.340.645.750'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.751'], ['E0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Conversion coefficients for the estimation of effective doses in intraoral and panoramic dental radiology from dose-area product values. | Conversion coefficients for the estimation of effective doses in intraoral and panoramic dental radiology from dose-area product (DAP) values were determined by measuring organ-absorbed doses and the corresponding DAP values. Measurements were performed for all standard intraoral radiological projections and standard p... | ['Algorithms', 'Body Burden', 'Humans', 'Models, Biological', 'Models, Statistical', 'Phantoms, Imaging', 'Radiation Dosage', 'Radiation Monitoring', 'Radiation Protection', 'Radiography, Dental', 'Relative Biological Effectiveness', 'Thermoluminescent Dosimetry'] | 18,550,517 | [['G17.035', 'L01.224.050'], ['E05.799.638.231', 'N06.850.460.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E07.671'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.799.638', 'N06.850.780.375.700', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Evaluation of different implementations of the Thomson liquid drop model: comparison to monovalent and divalent cluster ion experimental data. | The Thomson model, used for calculating thermodynamic properties of cluster ions from macroscopic properties, and variations of this model were compared to each other and to experimental data for both hydrated mono- and divalent ions. Previous models that used the Thomson equation to calculate sequential binding thermo... | ['Ions', 'Models, Chemical', 'Temperature', 'Thermodynamics', 'Water'] | 18,358,015 | [['D01.248.497'], ['E05.599.495'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Exploring common changes after acute mental stress and acute tryptophan depletion: Resting-state fMRI studies. | Stress and low serotonin levels are important biological factors in depression and anxiety etiologies. Although studies indicate that low serotonin levels, stress, and other factors may interact in depression/anxiety psychopathology, few studies have investigated the potentially shared neural substrates. We conducted r... | ['Acute Disease', 'Adult', 'Brain', 'Brain Mapping', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Rest', 'Stress, Psychological', 'Tryptophan', 'Young Adult'] | 30,959,228 | [['C23.550.291.125'], ['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['I03.450.769.647'], ['F01.145.126.990', 'F02.830.900'], ['D12.125.072.050.850', 'D12.125.142.875'], ['M01.060.116.... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Simulated ECT of the left ventricle using rotating slant-hole collimator and two camera positions. | Limited-angular-range tomography leads to an elongating distortion of the object in the direction of the z axis (perpendicular to the camera face). Two-view tomography appends to the usual data set another set of projections taken after the camera is rotated 90 degrees about an axis perpendicular to z. We investigated ... | ['Heart', 'Heart Ventricles', 'Humans', 'Models, Structural', 'Radioisotopes', 'Thallium', 'Tomography, Emission-Computed'] | 6,607,984 | [['A07.541'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['D01.496.749'], ['D01.268.556.847', 'D01.552.544.847'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800']] | ['Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Some sexual, personality, and demographic characteristics of women readers of erotic romances. | In two experiments, 24 college women and 48 housewives and businesswomen in Atlanta, Georgia, volunteered to fill out questionnaires to investigate sexual, personality, and demographic variables associated with the reading of best-selling erotic romances. While there were some differences in the results obtained from y... | ['Adolescent', 'Adult', 'Attitude', 'Erotica', 'Fantasy', 'Female', 'Gender Identity', 'Humans', 'Internal-External Control', 'Interpersonal Relations', 'Literature, Modern', 'Motivation', 'Reading', 'Self Concept', 'Sexual Behavior', 'Women'] | 6,466,084 | [['M01.060.057'], ['M01.060.116'], ['F01.100'], ['K01.517.414', 'L01.178.682.441'], ['F01.393.351', 'F02.463.188.634.507'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['F01.829.401'], ['K01.517.533'], ['F01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS. | Genomic technologies such as next-generation sequencing (NGS) are revolutionizing molecular diagnostics and clinical medicine. However, these approaches have proven inefficient at identifying pathogenic repeat expansions. Here, we apply a collection of bioinformatics tools that can be utilized to identify either known ... | ['Algorithms', 'Cerebellar Ataxia', 'Cohort Studies', 'Computational Biology', 'Family', 'Female', 'Genomics', 'Humans', 'Introns', 'Male', 'Microsatellite Repeats', 'Middle Aged', 'Polyneuropathies', 'Replication Protein C', 'Sensation Disorders', 'Syndrome', 'Vestibular Diseases', 'Whole Genome Sequencing'] | 31,230,722 | [['G17.035', 'L01.224.050'], ['C10.228.140.252.190', 'C10.597.350.090.500', 'C23.888.592.350.090.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['H01.158.273.180', 'L01.313.124'], ['F01.829.263', 'I01.880.853.150'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Name... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Hemocompatibility evaluation in vitro of methoxy polyethyleneglycol-polycaprolactone copolymer solutions. | Amphiphilic block copolymer methoxy polyethyleneglycol-polycaprolactone (mPEG-PCL) has attracted interest in the biomedical field, due to its water solubility and biodegradability. Nevertheless, the blood safety of mPEG-PCL copolymers has not been investigated in detail. Because mPEG-PCL copolymers introduced in vivo w... | ['Adenosine Diphosphate', 'Arachidonic Acid', 'Blood Coagulation', 'Cell Shape', 'Circular Dichroism', 'Complement Activation', 'Complement C3a', 'Erythrocytes', 'Fibrinogen', 'Hemolysis', 'Hemorheology', 'Humans', 'Kinetics', 'Materials Testing', 'Partial Thromboplastin Time', 'Platelet Aggregation', 'Polyesters', 'Po... | 26,481,428 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G09.188.390.150'], ['G04.320'], ['E05.196.867.151'], ['G12.274'], ['D12.776.124.486.274.024.250', 'D12.776.124.486.274.250.250'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Electromagnetic stimulation of the auditory system of deaf patients. | Electromagnetically induced auditory perception was investigated in 18 deaf patients who were candidates for cochlear implants. In the extracranial magnetic stimulation (EMS) procedure, patients were stimulated with time-varying magnetic field brief pulses from a coil positioned at the i) auricle, ii) the mastoid, and ... | ['Adolescent', 'Adult', 'Aged', 'Auditory Perception', 'Auditory Threshold', 'Cochlear Implants', 'Cochlear Nerve', 'Deafness', 'Electric Stimulation', 'Electromagnetic Fields', 'Female', 'Humans', 'Male', 'Middle Aged', 'Physical Stimulation', 'Tomography, X-Ray Computed', 'Vestibulocochlear Nerve'] | 7,825,431 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.593.071', 'G07.888.125'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['A08.800.800.120.910.120'], ['C09.218.458.341.186', 'C10.597.751.4... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Studies on detection of Candida antigen in the sera of mice inoculated orally with Candida albicans. | The authors succeeded in establishing a murine model of systemic candidiasis being disseminated from the primary gastrointestinal lesions caused by oral inoculation of Candida albicans. Using this model, an attempt was made for detecting the Candida antigen by enzyme-linked immunosorbent assay using avidin-biotin (AB-E... | ['Animals', 'Antigens, Fungal', 'Avidin', 'Biotin', 'Candida albicans', 'Candidiasis', 'Digestive System', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'Gastrointestinal Diseases', 'Intestine, Small', 'Leukocyte Count', 'Male', 'Mice', 'Predictive Value of Tests'] | 3,063,966 | [['B01.050'], ['D23.050.202'], ['D12.776.034.614.300', 'D12.776.256.159.157.663.300', 'D12.776.290.663.100', 'D12.776.395.175'], ['D03.383.129.308.080', 'D08.211.096'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C01.150.703.160'], ['A03'], ['C22.232', 'E05.598.500', 'E05.599.395.080'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Hematophagic activity of and environmental effect on the main malaria vector in Cuba: Anopheles albimanus]. | An ecological study of Anopheles (N) albimanus in a suburban population of Camag?ey province was carried out using a human bait in two trap points (indoor and outdoor). A higher quantity of females in the rainy season was observed together with a marked exophagic trend with peak activity in the early hours of the eveni... | ['Animals', 'Anopheles', 'Cuba', 'Disease Vectors', 'Environment', 'Feeding Behavior', 'Humans', 'Malaria', 'Seasons'] | 10,887,563 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['Z01.107.084.900.225', 'Z01.639.880.225'], ['N06.850.335.188', 'N06.850.520.203.375'], ['G16.500.275', 'N06.230'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530', 'C01.920.... | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Constitutive STAT5 phosphorylation in CD34+ cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity. | Primary Myelofibrosis (PMF) is a myeloproliferative disorder associated with JAK2V617F, Calreticulin (CALR) indels, and MPLW515L/K mutations activating the tyrosine kinase JAK2 and its downstream signaling pathway. The nature of signaling abnormalities in primary cells from PMF patients is poorly understood, since most... | ['Adult', 'Aged', 'Antigens, CD34', 'Calreticulin', 'Case-Control Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Janus Kinase 2', 'Male', 'Middle Aged', 'Mutation', 'Phosphorylation', 'Primary Myelofibrosis', 'Prognosis', 'STAT5 Transcription Factor', 'Severity of Illness Index', 'Tumor Suppressor Proteins'] | 31,369,569 | [['M01.060.116'], ['M01.060.116.100'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['D12.644.360.372.374', 'D12.776.157.125.412.374', 'D12.776.476.387.374', 'D12.776.503.303'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Experience with heparin-bonded collagen-coated grafts for infrainguinal bypass. | The perfect conduit for infrainguinal reconstructive surgery does not exist. When autologous vein is not available, then a prosthetic graft must be used. The use of a heparin-bonded graft has the theoretical advantage of reducing smooth muscle cell proliferation and thrombus formation, thereby reducing occlusion rates.... | ['Aged', 'Aged, 80 and over', 'Blood Vessel Prosthesis Implantation', 'Chronic Disease', 'Coated Materials, Biocompatible', 'Collagen', 'Female', 'Heparin', 'Humans', 'Intermittent Claudication', 'Ischemia', 'Leg', 'Male', 'Middle Aged', 'Treatment Outcome', 'Vascular Patency'] | 10,499,890 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.100.814.868.500', 'E04.650.200'], ['C23.550.291.500'], ['D25.130.420', 'J01.637.051.130.420'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.513'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Chromosome aberrations as a dosimetric technique for fission neutrons over the dose-range 0.2--50 rad. | An analysis of the literature shows a lack of data about basic biological parameters regarding cytogenetic dosimetry as applied to neutron fields, in the dose range below 50 rad. Human peripheral blood lymphocytes were exposed in vitro to a degraded fission neutron spectrum of mean energy 0.4 MeV. The dose-range was 0.... | ['Chromosome Aberrations', 'Dose-Response Relationship, Radiation', 'Humans', 'In Vitro Techniques', 'Lymphocytes', 'Male', 'Neutrons', 'Radiometry'] | 305,906 | [['C23.550.210', 'G05.365.590.175'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['G01.249.660.250'], ['E05.799']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Are honors received during surgery clerkships useful in the selection of incoming orthopaedic residents? | The purpose of this study was to review institutional statistics provided in dean's letters and determine the percentage of honors awarded by institution and clerkship specialty.Institutional and clerkship aggregate data were compiled from a review of dean's letters from 80 United States medical schools. The percentage... | ['Awards and Prizes', 'Clinical Clerkship', 'Educational Measurement', 'Humans', 'Internship and Residency', 'Orthopedics', 'Retrospective Studies', 'Schools, Medical', 'United States'] | 19,742,092 | [['K01.150'], ['I02.358.105'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.810.494'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.5... | ['Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Duodenal perforation caused by a bird feather. | Ingestion of gastrointestinal (GI) foreign bodies represents a challenging clinical scenario. The greater risk is at extremes of age, in those wearing dentures, alcoholics and mentally handicapped. We present a case of duodenal perforation caused by a bird feather. A 64-year-old man was presented with abdominal pain fo... | ['Animals', 'Birds', 'Duodenum', 'Feathers', 'Foreign Bodies', 'Humans', 'Intestinal Perforation', 'Laparotomy', 'Male', 'Middle Aged', 'Pneumoradiography'] | 23,417,953 | [['B01.050'], ['B01.050.150.900.248'], ['A03.556.124.684.124', 'A03.556.875.249'], ['A13.370'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.557'], ['E04.406'], ['M01.060.116.630'], ['E01.370.350.700.625']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
More cost-effective management of patients with musculoskeletal disorders in primary care after direct triaging to physiotherapists for initial assessment compared to initial general practitioner assessment. | BACKGROUND: A model for triaging patients in primary care to provide immediate contact with the most appropriate profession to treat the condition in question has been developed and implemented in parts of Sweden. Direct triaging of patients with musculoskeletal disorders (MSD) to physiotherapists at primary healthcare... | ['Adolescent', 'Adult', 'Aged', 'Cost-Benefit Analysis', 'Critical Pathways', 'Female', 'Follow-Up Studies', 'General Practitioners', 'Health Care Costs', 'Humans', 'Male', 'Middle Aged', 'Musculoskeletal Diseases', 'Nurses', 'Patient Acceptance of Health Care', 'Physical Therapists', 'Primary Health Care', 'Quality of... | 31,043,169 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N03.219.151.125'], ['N04.590.233.624.625', 'N04.590.275'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['M01.526.485.810.485', 'N02.360.810.485'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Multiplication of Toxoplasma gondii in maturing erythroid cells. | Multiplication of Toxoplasma gondii was examined in vitro in murine erythroid cells at different stages of development. Toxoplasma gondii multiplied in nucleated erythroblasts and enucleated reticulocytes from the foetal liver, and in immature reticulocytes and yolk-sac derived erythrocytes from the foetal circulation.... | ['Animals', 'Cell Differentiation', 'Cell Division', 'Erythroblasts', 'In Vitro Techniques', 'Mice', 'Reticulocytes', 'Time Factors', 'Toxoplasma'] | 7,420,056 | [['B01.050'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.148.378.590.837.250.200', 'A11.443.240.497.200', 'A15.378.316.378.590.837.250.200'], ['E05.481'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.118.290.760', 'A11.148.790', 'A11.443.240.665', 'A15.145.229.334... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical significance of second-trimester 50-g glucose challenge test among Japanese women diagnosed as normoglycemic after first-trimester 75-g glucose tolerance test. | OBJECTIVE: This study was performed to determine how often Japanese women diagnosed as normoglycemic on first-trimester 75-g glucose tolerance test (75gGTT) later develop gestational diabetes mellitus (GDM).MATERIAL AND METHODS: Sixty-two women with random plasma glucose (PG) level ? 105 mg/dL during the first trimeste... | ['Blood Glucose', 'Diabetes, Gestational', 'Fasting', 'Female', 'Glucose Tolerance Test', 'Humans', 'Insulin Resistance', 'Insulin-Secreting Cells', 'Japan', 'Pregnancy', 'Pregnancy Trimester, First', 'Pregnancy Trimester, Second'] | 26,927,241 | [['D09.947.875.359.448.500'], ['C13.703.170', 'C18.452.394.750.448', 'C19.246.200'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Sequence-specific 1H, 13C, and 15N resonance assignment of the autophagy-related protein Atg8. | The autophagy-related protein Atg8 is important for the formation of autophagosomes as it mediates membrane fusion. To elucidate the solution structure of Atg8 backbone and side chain chemical shifts of Atg8 were assigned as far as possible. | ['Amino Acid Sequence', 'Autophagy', 'Autophagy-Related Protein 8 Family', 'Carbon Isotopes', 'Magnetic Resonance Spectroscopy', 'Microtubule-Associated Proteins', 'Molecular Sequence Data', 'Nitrogen Isotopes', 'Protein Structure, Tertiary', 'Protein Subunits', 'Protons', 'Saccharomyces cerevisiae Proteins'] | 19,636,965 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G04.011'], ['D12.776.094.407', 'D12.776.220.600.450.100', 'D12.776.947.187'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.867.519'], ['D12.776.220.600.450', 'D12.776.631.560'], ['L01.453.245.667'], ['D01.268.604.500', 'D01.362.625.500', 'D01.496.586'], ['G02.111.570.820.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The Incorporation of Marine Coral Microparticles into Collagen-Based Scaffolds Promotes Osteogenesis of Human Mesenchymal Stromal Cells via Calcium Ion Signalling. | Composite biomaterial scaffolds consisting of natural polymers and bioceramics may offer an alternative to autologous grafts for applications such as bone repair. Herein, we sought to investigate the possibility of incorporating marine coral microparticles into a collagen-based scaffold, a process which we hypothesised... | ['Animals', 'Anthozoa', 'Biocompatible Materials', 'Bone Regeneration', 'Calcium', 'Cells, Cultured', 'Collagen', 'Gene Expression Profiling', 'Humans', 'Materials Testing', 'Mesenchymal Stem Cells', 'Osteogenesis', 'Primary Cell Culture', 'Spectroscopy, Fourier Transform Infrared', 'Tissue Engineering', 'Tissue Scaffo... | 31,979,233 | [['B01.050'], ['B01.050.500.308.237'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G11.427.213.140', 'G16.762.150.150'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Review of electroconvulsive therapy practice from a tertiary Child and Adolescent Psychiatry Centre. | AIMS AND OBJECTIVES: The use of electroconvulsive therapy (ECT) in children and adolescents is a controversial issue. This study was done to examine the pattern and practice as well as the outcome of electroconvulsive therapy administered to children and adolescents admitted to a tertiary care centre.METHODOLOGY: A 10 ... | ['Adolescent', 'Adolescent Psychiatry', 'Antipsychotic Agents', 'Catatonia', 'Child', 'Child Psychiatry', 'Combined Modality Therapy', 'Electroconvulsive Therapy', 'Female', 'Humans', 'Male', 'Mental Disorders', "Practice Patterns, Physicians'", 'Retrospective Studies', 'Treatment Outcome'] | 25,440,568 | [['M01.060.057'], ['F04.096.544.065', 'H02.403.690.080'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['C10.597.606.115', 'C23.888.592.604.115', 'F01.145.126.156', 'F01.700.165'], ['M01.060.406'], ['F04.096.544.193', 'H02.403.690.130'], ['E02.186'], ['F04.570.200.583', 'F0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Insurance-related differences in the risk of ruptured appendix. | BACKGROUND: We studied differences in the incidence of appendiceal perforation in patients with acute appendicitis according to their insurance coverage.METHODS: In a retrospective analysis of hospital-discharge data, we examined the likelihood of ruptured appendix among adults 18 to 64 years old who were hospitalized ... | ['Adolescent', 'Adult', 'Appendicitis', 'California', 'Confidence Intervals', 'Female', 'Health Services Accessibility', 'Humans', 'Insurance, Hospitalization', 'Intestinal Perforation', 'Male', 'Medicaid', 'Medically Uninsured', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Retrospective Studies', 'Risk Facto... | 7,880,234 | [['M01.060.057'], ['M01.060.116'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of preculture variability on clavulanic acid fermentation. | The production profile of clavulanic acid by Streptomyces clavuligerus was shown to be strongly dependent on inoculum activity. Two sets of fermentations (A and B) were investigated at industrial pilot-plant scale using complex media. Type A fermentations were inoculated using late exponential growth phase mycelia. Typ... | ['Anti-Bacterial Agents', 'Bioreactors', 'Cell Culture Techniques', 'Clavulanic Acid', 'Fermentation', 'Streptomyces'] | 11,460,254 | [['D27.505.954.122.085'], ['E07.115', 'J01.897.120.115'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['D02.065.589.099.374.160', 'D03.633.100.300.374.160'], ['G02.111.158.249', 'G03.191.249'], ['B03.300.390.400.810.768', 'B03.510.024.997.775', 'B03.510.415.400.810.768', 'B03.510.460.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Antimicrobial tissue penetration in a rat model of E. coli epididymitis. | Following induction of unilateral epididymitis by intratesticular injection of E. coli, a single intraperitoneal dose of amdinocillin, ampicillin, doxycycline, tobramycin, or trimethoprim/sulfamethoxazole was administered to five groups of rats. The animal was sacrificed serially and concentrations of antibiotic in ser... | ['Animals', 'Anti-Bacterial Agents', 'Cell Membrane Permeability', 'Chromatography, High Pressure Liquid', 'Disease Models, Animal', 'Epididymis', 'Epididymitis', 'Escherichia coli Infections', 'Male', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 1,942,312 | [['B01.050'], ['D27.505.954.122.085'], ['G03.143.335', 'G04.175'], ['E05.196.181.400.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A05.360.444.371'], ['C12.294.199'], ['C01.150.252.400.310.330'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Swenson's pull-through in older children and adults: peculiar peri-operative challenges of surgery. | INTRODUCTION: The definitive treatment of Hirschsprung's disease is removal of the aganglionic bowel by a pull-through surgery. In most cases this surgery is performed in infancy or the neonatal period as presentation in older children and adulthood is rare. Nevertheless, pull-through in this age group may be necessary... | ['Adolescent', 'Adult', 'Anal Canal', 'Anastomosis, Surgical', 'Child', 'Child, Preschool', 'Colectomy', 'Colon', 'Colostomy', 'Constipation', 'Female', 'Follow-Up Studies', 'Hirschsprung Disease', 'Humans', 'Intestinal Obstruction', 'Male', 'Prospective Studies', 'Treatment Outcome', 'Young Adult'] | 21,945,674 | [['M01.060.057'], ['M01.060.116'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['E04.035'], ['M01.060.406'], ['M01.060.406.448'], ['E04.210.219'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E04.210.338.225', 'E04.579.338.225'], ['C23.888.821.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', '... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury. | A number of studies have established a deleterious role for inflammatory molecules and reactive oxygen species (ROS) in the pathology of traumatic brain injury (TBI). Caffeic acid phenethyl ester (CAPE) has been shown to exert both antioxidant and anti-inflammatory effects. The primary objective of the present study wa... | ['Animals', 'Blood-Brain Barrier', 'Brain Injuries', 'Caffeic Acids', 'Disease Models, Animal', 'Fluorescent Antibody Technique', 'Immunohistochemistry', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Neuroprotective Agents', 'Phenylethyl Alcohol', 'Rats', 'Rats, Sprague-Dawley', 'Recovery of Function'] | 22,150,135 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['D02.241.223.200.054'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['E01.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Genotype 3 hepatitis E has been widespread in pig farms of Shanghai suburbs. | Hepatitis E virus (HEV) genotype 3 was first identified in swine raised on a Shanghai suburban pig farm in late 2006. To accurately determine the prevalence of HEV infections among Shanghai pig farms, 426 pig fecal samples were collected from 37 pig farms located in all 10 Shanghai suburban districts and tested for the... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Agriculture', 'Animals', 'Animals, Domestic', 'China', 'Feces', 'Genetic Variation', 'Genotype', 'Hepatitis E', 'Hepatitis E virus', 'Lansoprazole', 'Phylogeny', 'Suburban Population', 'Swine', 'Swine Diseases'] | 17,706,381 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['J01.040'], ['B01.050'], ['B01.050.050.116'], ['Z01.252.474.164'], ['A12.459'], ['G05.365'], ['G05.380'], ['C01.925.440.470', 'C01.925.782.455', 'C06.552.380.705.470'], ['B04.450.412', 'B04.820.578.407.400'], ['D02.886.640.074.249', 'D03.383.725.024.249',... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Variation in Institutional Review processes for a multisite observational study. | BACKGROUND: The Veterans Administration is an ideal setting for multisite studies; however, individual VA Institutional Review Board (IRB) approval is necessary. This study examines the burden of multisite IRB approval on a Health Services Research and Development (HSRD) ventral hernia outcomes observational study.METH... | ['Ethics Committees, Research', 'Health Services Research', 'Hernia, Ventral', 'Humans', 'Observation', 'Outcome Assessment, Health Care', 'Program Evaluation', 'United States', 'United States Department of Veterans Affairs'] | 16,226,962 | [['K01.752.566.479.147.750', 'N04.452.758.788.300.750', 'N05.350.268.750', 'N05.700.685.300.750'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['C23.300.707.374.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581.249'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E05.337.82... | ['Humanities [K]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Lack of interaction between a polymorphism in the dopamine D2 receptor gene and the clinical features of migraine. | The purpose of this study was to evaluate whether a particular genotype of the dopamine D2 receptor (DRD2) gene would affect the clinical features of migraine. In a group of 118 migraineurs (55 migraine with aura and 63 migraine without aura patients), we tested the association of the biallelic C/T NcoI DRD2 polymorphi... | ['Adult', 'Analysis of Variance', 'Chi-Square Distribution', 'Female', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Polymorphism, Genetic', 'Receptors, Dopamine D2'] | 15,154,861 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.546.399.750'], ['G05.365.795'], ['D12.776.543.750.670.300... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis. | PURPOSE: Pain in patients with endometriosis is considered a significant source of stress but does not always correlate with severity of the condition. We have demonstrated that stress can worsen endometriosis in an animal model. Here, we tested the impact of a psychological stress protocol on pain thresholds and pain ... | ['Animals', 'Anxiety', 'Corticosterone', 'Disease Models, Animal', 'Endometriosis', 'Enkephalins', 'Female', 'Oligopeptides', 'Pain Measurement', 'Pain Perception', 'Pain Threshold', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Neurokinin-1', 'Receptors, Opioid, mu', 'Spinal Cord', 'Stress, Psychological', 'Substance P'... | 28,093,054 | [['B01.050'], ['F01.470.132'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C13.351.500.163'], ['D12.644.400.575.281', 'D12.776.631.650.575.281'], ['D12.644.456'], ['E01.370.600.550.324'], ['F02.463.593.504'], ['F02.463.593.710.560', 'F02.830.816.444.700',... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Both basal and ontogenic promoter elements affect the timing and level of expression of a sea urchin H1 gene during early embryogenesis. | Late histone H1-beta mRNA accumulates with the correct ontogenic pattern following microinjection of the cloned gene into fertilized sea urchin eggs. Sequences upstream of the gene encoding the sea urchin H1-beta protein contain both basal and developmentally regulated elements. One late H1-specific activator sequence ... | ['Animals', 'Base Sequence', 'DNA', 'Gene Expression Regulation', 'Histones', 'Molecular Sequence Data', 'Mutation', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Sea Urchins', 'Time Factors'] | 3,360,321 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['G05.308'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['L01.453.245.667'], ['G05.365.590'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D13.444.735.544'], ['B0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changes in the iliac crest-lumbar relationship from standing to prone. | BACKGROUND CONTEXT: It is known that positioning patients on the Jackson and Andrews operative tables causes changes in lumbar lordosis and pelvic rotation. However, it is unknown if the relationship between the iliac crest and underlying lumbar levels, in particular the L4-L5 interspace, changes from standing to prone... | ['Adult', 'Aged', 'Aged, 80 and over', 'Equipment Design', 'Female', 'Humans', 'Ilium', 'Intraoperative Care', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Preoperative Care', 'Prone Position', 'Radiography', 'Spine', 'Surgical Equipment', 'Surgical Procedures, Operative'] | 16,517,391 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.825.434'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['G11.427... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Surgical strategy based on the spread mode of gallbladder carcinoma]. | Cancer recurs even from early stage of gallbladder cancer if the bile spills over during surgery. The most important point to determine the surgical strategy for gallbladder cancer is the spread mode For pT1b gallbladder cancer, cholecystectomy in the entire layer and regional lymphadenectomy are necessary. Even for pT... | ['Bile Ducts, Extrahepatic', 'Cholecystectomy', 'Gallbladder Neoplasms', 'Hepatectomy', 'Humans', 'Lymph Node Excision', 'Lymphatic Metastasis', 'Neoplasm Invasiveness'] | 15,859,139 | [['A03.159.183.079'], ['E04.210.120.172'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.697.645', 'C23.550.727.645']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The dynamics of maternal-effect selfish genetic elements. | Maternal-effect selfish genes such as Medea or Scat act to kill progeny that do not bear a copy of the selfish gene present in the mother. Previous models of this system allowed for two types of allele, the selfish (killer) type and the sensitive (susceptible) wild-type. These models predict that the invasion condition... | ['Alleles', 'Animals', 'Computational Biology', 'Female', 'Genes, Lethal', 'Genetics, Population', 'Models, Genetic', 'Population Dynamics', 'Zygote'] | 9,631,565 | [['G05.360.340.024.340.030'], ['B01.050'], ['H01.158.273.180', 'L01.313.124'], ['G05.360.340.024.340.350'], ['H01.158.273.343.335'], ['E05.599.395.397'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['A05.360.490.690.970', 'A11.497.497.950', 'A16.950']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. | PURPOSE: Little progress has been made in the treatment of adult high-grade gliomas over the last two decades, thus necessitating a search for novel therapeutic strategies. Malignant gliomas are vascular or angiogenic tumors, which leads to the supposition that angiogenesis inhibition may represent a potentially promis... | ['Adult', 'Aged', 'Angiogenesis Inhibitors', 'Biomarkers, Tumor', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Constipation', 'Disease Progression', 'Female', 'Fibroblast Growth Factor 2', 'Follow-Up Studies', 'Glioblastoma', 'Glioma', 'Humans', 'Hypnotics and Sedatives', 'Male', 'Middle Aged', 'Neoplasm Rec... | 10,673,511 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D23.101.140'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['C23.888.821.150'], ['C23.550.291.656'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['E05.318.372.500.750.249', 'N0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bilateral asymmetric popliteal entrapment syndrome treated with successful surgical decompression and adjunctive thrombolysis. | Popliteal artery entrapment syndrome (PAES) is the most common cause of lower leg claudication in patients younger than 50 years. The different types of PAES can result in different rates of arterial damage, leading to aneurysmal degeneration or occlusion. We report a rare case of a young patient presenting with asymme... | ['Adolescent', 'Angiography, Digital Subtraction', 'Arterial Occlusive Diseases', 'Combined Modality Therapy', 'Constriction, Pathologic', 'Decompression, Surgical', 'Humans', 'Intermittent Claudication', 'Ischemia', 'Male', 'Muscle, Skeletal', 'Nerve Compression Syndromes', 'Popliteal Artery', 'Saphenous Vein', 'Tendo... | 19,628,519 | [['M01.060.057'], ['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['C14.907.137'], ['E02.186'], ['C23.300.287'], ['E04.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.513'], ['A... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Poor response to interferon treatment for chronic hepatitis C in human immunodeficiency virus-infected haemophiliacs. | We performed a pilot study to evaluate the factors associated with response to interferon (IFN) therapy for chronic hepatitis C (CHC) with human immunodeficiency virus (HIV) coinfected haemophiliacs. Seven haemophiliacs, coinfected with HIV and hepatitis C virus (HCV), received 9 mega-units (MU) of natural IFN-alpha da... | ['Adult', 'Anti-HIV Agents', 'Antiviral Agents', 'Didanosine', 'HIV Infections', 'Hemophilia A', 'Hepatitis C, Chronic', 'Humans', 'Interferon-alpha', 'Middle Aged', 'Pilot Projects', 'Treatment Outcome', 'Zidovudine'] | 11,122,395 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['D27.505.954.122.388'], ['D03.633.100.759.590.616.130', 'D13.570.230.500.090', 'D13.570.583.616.130', 'D13.570.800.573.130'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C15.378.100.100.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor. | In the present study the role of Akt/PKB (protein kinase B) in PIF- (proteolysis-inducing factor) induced protein degradation has been investigated in murine myotubes. PIF induced transient phosphorylation of Akt at Ser(473) within 30 min, which was attenuated by the PI3K (phosphoinositide 3-kinase) inhibitor LY294002 ... | ['Animals', 'Cell Line', 'Mice', 'Muscle Fibers, Skeletal', 'Muscle Proteins', 'Phosphatidylinositol 3-Kinases', 'Phosphoinositide-3 Kinase Inhibitors', 'Phosphorylation', 'Protein Kinases', 'Proteoglycans', 'Proto-Oncogene Proteins c-akt', 'Signal Transduction', 'TOR Serine-Threonine Kinases', 'Ubiquitin'] | 17,961,125 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.505.500'], ['A10.690.552.500.500', 'A11.620.249'], ['D12.776.210.500'], ['D08.811.913.696.620.500'], ['D27.505.519.389.736'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D08.811.913.696.620.682'], ['D09.698.735', 'D12.776.395.650'], ['D08.811.913.696.620... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subtrochanteric femoral fractures treated with the Long Gamma3® nail: A historical control case study versus Long trochanteric Gamma nail®. | BACKGROUND: Gamma nail was developed for the treatment of subtrochanteric hip fractures. Despite its advantages over extramedullary devices, gamma nail has been historically related to significant complications (implant breakage, femoral fractures at the tip of the nail). There is limited data to determine if the rate ... | ['Adult', 'Aged', 'Bone Nails', 'Equipment Design', 'Female', 'Fracture Fixation, Intramedullary', 'Hip Fractures', 'Humans', 'Intraoperative Complications', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prospective Studies', 'Reoperation', 'Treatment Outcome'] | 26,315,346 | [['M01.060.116'], ['M01.060.116.100'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['E05.320'], ['E04.555.300.300.300'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Crystallization and preliminary crystal data of porcine pepsinogen. | Single crystals of porcine pepsinogen, suitable for x-ray diffraction studies, have been grown with lithium sulfate as the precipitant. These pepsinogen crystals were dissolved, activated, and assayed for proteolytic activity. The specific enzymic activity of the dissolved crystalline protein was nearly twice that of t... | ['Animals', 'Crystallization', 'Pepsinogens', 'Protein Conformation', 'Swine', 'X-Ray Diffraction'] | 562,881 | [['B01.050'], ['E05.196.300', 'G02.171'], ['D08.622.509', 'D12.776.811.243.509'], ['G02.111.570.820.709'], ['B01.050.150.900.649.313.500.880'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of endothelinA receptors in cerebral and peripheral arteries of the rat. | We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [125I]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ETA an... | ['Animals', 'Arteries', 'Autoradiography', 'Cerebral Arteries', 'Endothelins', 'Iodine Radioisotopes', 'Male', 'Protein Binding', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Endothelin A', 'Receptors, Endothelin'] | 7,716,066 | [['B01.050'], ['A07.015.114'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A07.015.114.228'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae. | Monoterpene production in Saccharomyces cerevisae requires the introduction of heterologous monoterpene synthases (MTSs). The endogenous farnesyl pyrosphosphate synthase (FPPS; Erg20p) competes with MTSs for the precursor geranyl pyrophosphate (GPP), which limits the production of monoterpenes. ERG20 is an essential ge... | ['Geranyltranstransferase', 'Metabolic Engineering', 'Monoterpenes', 'Proteolysis', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 29,471,044 | [['D08.811.913.225.450'], ['E05.393.420.526', 'E05.481.500.311.249', 'J01.293.069.249.249'], ['D02.455.849.575'], ['G02.111.720', 'G03.812'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Thyroxine-Based Screening for Congenital Hypothyroidism in Neonates with Down Syndrome. | OBJECTIVE: To ascertain whether thyroxine (T4)-based screening programs for congenital hypothyroidism (initial measurement of total T4 [tT4] followed by thyroid stimulating hormone [TSH] measurement in patients with tT4 <10th percentile) identifies congenital hypothyroidism in all neonates with Down syndrome.STUDY DESI... | ['Case-Control Studies', 'Cohort Studies', 'Congenital Hypothyroidism', 'Down Syndrome', 'Hormone Replacement Therapy', 'Humans', 'Infant', 'Infant, Newborn', 'Neonatal Screening', 'Retrospective Studies', 'Thyroid Function Tests', 'Thyrotropin', 'Thyroxine'] | 26,995,701 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C05.116.099.343.347', 'C05.116.132.256', 'C16.320.240.625', 'C19.297.155', 'C19.874.482.281'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kinetics of activation of the potassium conductance in the squid giant axon. | A quantitative re-investigation of the time course of the initial rise of the potassium current in voltage-clamped squid giant axons is described. The n4 law of the Hodgkin-Huxley equations was found to be well obeyed only for the smallest test pulses, and for larger ones a good fit of the inflected rise required use o... | ['Animals', 'Axons', 'Decapodiformes', 'Electric Conductivity', 'Kinetics', 'Mathematics', 'Potassium', 'Schwann Cells', 'Temperature'] | 2,895,477 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.500.644.116.150'], ['G01.358.500.249.277'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['A08.637.800', 'A08.800.800.690', 'A11.650.800'], ['G0... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Pure oxygen breathing increases sheep lung microvascular permeability. | Sheep that breathe pure oxygen via a tracheostomy develop progressive respiratory failure and die within four days. The characteristic terminal findings include an increased water content of the lung, a decrease in lung compliance, and severe hypercarbia. To sequentially assess alterations of lung transvascular fluid d... | ['Animals', 'Capillary Permeability', 'Lung', 'Lymph', 'Microcirculation', 'Oxygen', 'Proteins', 'Pulmonary Edema', 'Sheep', 'Time Factors'] | 6,824,169 | [['B01.050'], ['G03.143.330', 'G09.330.165'], ['A04.411'], ['A12.207.270.606', 'A15.382.520.150'], ['G09.330.100.645'], ['D01.268.185.550', 'D01.362.670'], ['D12.776'], ['C08.381.742'], ['B01.050.150.900.649.313.500.380.791'], ['G01.910.857']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS). | The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, w... | ['Adolescent', 'Adult', 'Aged', 'California', 'Case-Control Studies', 'Cohort Studies', 'Endophenotypes', 'Family', 'Female', 'Humans', 'Male', 'Memory, Short-Term', 'Mental Recall', 'Middle Aged', 'Neuropsychological Tests', 'Recognition, Psychology', 'Schizophrenia', 'Schizophrenic Psychology', 'Speech Perception', '... | 25,497,440 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.695.224'], ['F01.829.263', 'I01.880.853.150'... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Pulse transit time as a surrogate measure of changes in systolic arterial pressure in children during sleep. | Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aime... | ['Adolescent', 'Arterial Pressure', 'Child', 'Electrocardiography', 'Female', 'Humans', 'Male', 'Photoplethysmography', 'Polysomnography', 'Pulse Wave Analysis', 'Sleep', 'Sleep Apnea Syndromes', 'Sleep Stages'] | 24,605,887 | [['M01.060.057'], ['G09.330.380.076.347'], ['M01.060.406'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.610.600'], ['E01.370.520.625'], ['E01.370.370.680'], ['F02.830.855', 'G11.561.803'], ['C08.618.085.852', 'C10.886.425.800.750'], ['F02.830.855.796', 'G11... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts. | Insulin-like growth factor-I (IGF-I) improves glucose metabolism and growth in patients with leprechaunism. We investigated signal transduction through IGF-I receptor in comparison with epidermal growth factor (EGF) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprech... | ['Adaptor Proteins, Signal Transducing', 'Adaptor Proteins, Vesicular Transport', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Cell Division', 'Cells, Cultured', 'Enzyme Activation', 'Epidermal Growth Factor', 'Fibroblast Growth Factor 2', 'Fibroblasts', 'Humans', 'Immunosorbent Techniques', 'Insulin Receptor Subst... | 9,003,010 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.543.990.150'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['G02.111.263', 'G03.328'], ['D06.472.317.350', 'D12.644.276.382.500', 'D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phase retrieval using polychromatic illumination for transmission X-ray microscopy. | An alternative method for quantitative phase retrieval in a transmission X-ray microscope system at sub-50-nm resolution is presented. As an alternative to moving the sample in the beam direction in order to analyze the propagation-introduced phase effect, we have illuminated the TXM using X-rays of different energy wi... | ['Colorimetry', 'Lighting', 'Microscopy, Electron, Transmission', 'Radiographic Image Interpretation, Computer-Assisted'] | 21,263,593 | [['E05.196.922.250'], ['N06.230.150.410'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['E01.158.600.680', 'E01.370.350.350.700', 'E01.370.350.700.705', 'L01.313.500.750.100.158.600.680']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Duloxetine in adults with ADHD: a randomized, placebo-controlled pilot study. | OBJECTIVE: To assess the effect of duloxetine on ADHD in adults.METHOD: In a 6-week double-blind trial, 30 adults with ADHD received placebo or duloxetine 60 mg daily. The Conners' Adult ADHD Rating Scale (CAARS) and the Clinical Global Impression Scales (CGI) were used to assess symptom severity and clinical improveme... | ['Adolescent', 'Adult', 'Antidepressive Agents', 'Attention Deficit Disorder with Hyperactivity', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Duloxetine Hydrochloride', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personality Inventory', 'Pilot Projects', 'Psychiatric Stat... | 22,582,349 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.700.122'], ['F03.625.094.150'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['D02.886.778.260', 'D03.383.903.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Blood gas changes and hypophosphatemia in lactate-induced panic. | Alkalosis is prominent among the many physiologic and biochemical effects of sodium lactate infusion. Though this is partially due to the conversion of lactate to bicarbonate, the metabolic component, it may also be secondary to hyperventilation before and during the infusion, the respiratory component. We analyzed pH,... | ['Adult', 'Alkalosis', 'Alkalosis, Respiratory', 'Anxiety Disorders', 'Carbon Dioxide', 'Fear', 'Female', 'Humans', 'Hyperventilation', 'Lactates', 'Lactic Acid', 'Male', 'Middle Aged', 'Oxygen', 'Panic', 'Phosphates'] | 3,094,475 | [['M01.060.116'], ['C18.452.076.354'], ['C08.618.501.271', 'C18.452.076.354.271'], ['F03.080'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.618.501', 'C23.888.852.591'], ['D02.241.511.459'], ['D02.241.511.459.450'], ['M01.060.116.630'], ['D0... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Neuralgic amyotrophy]. | Neuralgic amyotrophy is an inflammatory condition of the nerves of the brachial plexus, the cause of which is unknown. Clinically, it presents as acute, severe pain in the shoulder girdle, followed by paresthesia and flaccid paralysis of selected muscles in the upper limb. In its initial stages, the disease may easily ... | ['Adult', 'Brachial Plexus Neuritis', 'Diagnosis, Differential', 'Humans', 'Male', 'Prognosis'] | 9,531,827 | [['M01.060.116'], ['C10.668.829.100.500', 'C10.668.829.650.250'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The aggregate income losses from childhood stunting and the returns to a nutrition intervention aimed at reducing stunting. | We undertake two calculations, one for all developing countries, the other for 34 developing countries that together account for 90% of the world's stunted children. The first asks how much lower a country's per capita income is today as a result of having a fraction of its workforce been stunted in childhood. We use a... | ['Adult', 'Body Height', 'Child', 'Child Development', 'Child Nutrition Disorders', 'Child, Preschool', 'Cost-Benefit Analysis', 'Developing Countries', 'Health Promotion', 'Humans', 'Nutritional Status', 'Salaries and Fringe Benefits'] | 31,003,858 | [['M01.060.116'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['C18.654.180'], ['M01.060.406.448'], ['N03.219.151.125'], ['I01.615.500.300'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats. | OBJECTIVES: Dynamically observe cerebral vascular changes in hyperglycemic rats in vivo and explore the effect of diabetes on endothelial function after ischemic stroke.BACKGROUND: Diabetes affects both large and small vessels in the brain, but the dynamic process and mechanism are unclear.METHODS: We investigated the ... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'Animals', 'Brain', 'Cerebral Angiography', 'Cerebral Arteries', 'Cerebral Hemorrhage', 'Diabetes Mellitus, Experimental', 'Endothelium, Vascular', 'Hyperglycemia', 'Infarction, Middle Cerebral Artery', 'NG-Nitroarginine Methyl Ester', 'Neuroprotective Agents', 'Organ S... | 26,842,484 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['B01.050'], ['A08.186.211'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['A07.015.114.228'], ['C10.228.140.300.535.200', 'C14.907.253.573.200'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison and Interpretation of Taxonomical Structure of Bacterial Communities in Two Types of Lakes on Yun-Gui plateau of China. | Bacterial communities from freshwater lakes are shaped by various factors such as nutrients, pH value, temperature, etc. Their compositions and relative abundances would undergo changes to adapt the changing environments, and in turn could affect the environments of freshwater lakes. Analyses of the freshwater lake's b... | ['Bacteria', 'Biodiversity', 'China', 'Ecosystem', 'Lakes', 'Microbiota', 'RNA, Ribosomal, 16S', 'Water Microbiology'] | 27,461,070 | [['B03'], ['G16.500.275.157.049', 'N06.230.124.049'], ['Z01.252.474.164'], ['G16.500.275.157', 'N06.230.124'], ['G01.311.580', 'G16.500.275.280.500', 'N06.230.232.500'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['D13.444.735.686.670'], ['H01.158.273.540.274.777', 'N06.850.425.450']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
A phase 2 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 vaccine based on adeno-associated virus. | The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2) vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced robust T cell and antibody responses in nonhuman primates. In a previous phase I study in 80 healthy HIV-seronegative European and Indian adult... | ['AIDS Vaccines', 'Adult', 'Antibodies, Neutralizing', 'Antibody Formation', 'Dependovirus', 'Double-Blind Method', 'Female', 'Genetic Vectors', 'HIV Antibodies', 'HIV Infections', 'HIV-1', 'Humans', 'Immunization Schedule', 'Male', 'Middle Aged', 'T-Lymphocytes', 'Vaccines, Synthetic', 'Young Adult'] | 20,666,584 | [['D20.215.894.899.050'], ['M01.060.116'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['G12.450.050.370.250'], ['B04.280.580.650.170'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G05.360.337'], ['D12.776.124.486.485.114.254... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of medial preoptic oestradiol implants on hypothalamic beta-endorphin concentration. | Twenty-four-day-old immature and cyclic female rats in metoestrus were ovariectomized and bilaterally implanted with oestradiol benzoate (OB) and cholesterol at a ratio of 1:360 or with cholesterol alone in the medial preoptic area (MPOA), or, for control, the hypothalamic dorsomedial nucleus. Estimation of beta-endorp... | ['Animals', 'Cholesterol', 'Drug Implants', 'Estradiol', 'Estrogens', 'Feedback', 'Female', 'Luteinizing Hormone', 'Optic Chiasm', 'Radioimmunoassay', 'Rats', 'Rats, Inbred Strains', 'beta-Endorphin'] | 2,970,394 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D26.255.210.315'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D27.505.696.399.472.277'], ['L01.906.394.211'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['A08.186.211... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Preliminary analysis of the transmission dynamics of nosocomial infections: stochastic and management effects. | A simple mathematical model is developed for the spread of hand-borne nosocomial pathogens such as Staphylococcus aureus within a general medical-surgical ward. In contrast to previous models a stochastic approach is used. Computer simulations are used to explore the properties of the model, and the results are present... | ['Computer Simulation', 'Cross Infection', 'Hand Disinfection', 'Humans', 'Infectious Disease Transmission, Professional-to-Patient', 'Length of Stay', 'Models, Biological', 'Monte Carlo Method', 'Prevalence', 'Staphylococcal Infections'] | 10,549,313 | [['L01.224.160'], ['C01.248', 'C23.550.291.875.500'], ['N06.850.670.150.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.750'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.599.395'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E05.318.308.985.525.75... | ['Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Mining the human genome for new health therapies. | The completion of the Human Genome Project heralds advances in determining the foundations of disease and in developing new therapeutic treatments. Tests already exist for the detection of some genetic abnormalities that can cause disease, and more are being developed. In the future, pharmacogenetics will be used to ta... | ['Female', 'Genetic Diseases, Inborn', 'Genome, Human', 'Humans', 'Pharmacogenetics', "Women's Health"] | 15,126,091 | [['C16.320'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.273.343.750', 'H01.158.703.052', 'H02.628.479'], ['N01.400.900']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Enteric coccidiosis among patients with the acquired immunodeficiency syndrome. | Ten patients were identified at Jackson Memorial hospital/University of Miami Hospitals and Clinics with enteric coccidial infection due to Cryptosporidium spp. or Isospora belli. All had the acquired immunodeficiency syndrome as manifested by Kaposi's sarcoma or multiple opportunistic infections, or both. They present... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Animals', 'Coccidiosis', 'Cryptosporidiosis', 'Cryptosporidium', 'Diarrhea', 'Drug Combinations', 'Female', 'Furazolidone', 'Humans', 'Intestinal Diseases, Parasitic', 'Isospora', 'Leucomycins', 'Male', 'Middle Aged', 'Sulfamethoxazole', 'Trimethoprim', 'Trimethoprim, Su... | 6,334,448 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['B01.050'], ['C01.610.752.250'], ['C01.610.432.269', 'C01.610.701.688.235', 'C01.610.752.250.269', 'C01.610.752.625.235', 'C06.405.469... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Association and intrinsic connections of human extrastriate visual cortex. | Human extrastriate visual cortex contains several functionally defined visual areas of which four (V2, VP, V4 and V5) can be identified using cyto- and myeloarchitectonic criteria. A case with a small lesion in the superolateral part of cytoarchitectonic area 19, outside the previously defined visual areas, has been st... | ['Afferent Pathways', 'Aged', 'Aged, 80 and over', 'Brain Mapping', 'Cerebral Infarction', 'Female', 'Functional Laterality', 'Humans', 'Nerve Fibers', 'Neurons', 'Pyramidal Cells', 'Visual Cortex'] | 8,090,794 | [['A08.612.220'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['F02.830... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The GnRH-TRH double stimulation test before and following surgical removal of uterine leiomyoma]. | In seven patients with uterine leiomyomatosis investigated the function of hypothalamic-pituitary-ovarian axis has been with a GnRH-TRH-double stimulation test. The basal levels of estradiol, progesterone, LH, FSH and PRL as well as the pituitary reaction after the stimulation were determined. Three patients had a tend... | ['Adult', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Follow-Up Studies', 'Gonadal Steroid Hormones', 'Gonadotropin-Releasing Hormone', 'Humans', 'Hysterectomy', 'Leiomyoma', 'Luteinizing Hormone', 'Middle Aged', 'Postoperative Complications', 'Progesterone', 'Prolactin', 'Thyrotropin-Releasing Hormone', 'U... | 2,110,707 | [['M01.060.116'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D06.472.334.851'], ['D06.472.699.327.740.320', 'D12.644.400.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanism of binding of mouse interferon to controlled pore glass. | Many proteins bind to controlled pore glass; they are either acid elutable or alkali elutable. Mouse interferon is an acid-elutable protein. Since poly(L-lysine) and, to some extent, poly(L-arginine) are also eluted from controlled pore glass under acidic conditions, one may postulate that mouse interferon binds to con... | ['Adsorption', 'Animals', 'Chemical Phenomena', 'Chemistry', 'Chromatography', 'Glass', 'Interferons', 'Maleates', 'Mice', 'Peptides', 'Polylysine', 'Protein Binding', 'Zirconium'] | 94,835 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Will the money tree grow another branch for us? | It would be churlish in the extreme to appear unimpressed by the government's announcement of plans to increase staffing numbers in mental health services. | ['Mental Health Services', 'United Kingdom'] | 28,831,891 | [['F04.408', 'N02.421.461'], ['Z01.542.363']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Incorporating Rapid Cycle Deliberate Practice Into Nursing Staff Continuing Professional Development. | Rapid Cycle Deliberate Practice (RCDP) is an innovative concept used to teach a sequence of predetermined skills to learners in a short period of time. When implemented correctly, learners build on their actions (deliberate practice) repeatedly, over a short period of time (rapid cycle). Incorporating RCDP into a nursi... | ['Clinical Competence', 'Education, Nursing, Continuing', 'Heart Arrest', 'Humans', 'Nursing Staff, Hospital', 'Practice Guidelines as Topic', 'Program Evaluation', 'Staff Development'] | 26,154,670 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.212.450', 'I02.358.462.399'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['N04.761.700.350.650', 'N05.700.350.650'], ['E05.337.820', 'N04.761.685', '... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Rates and durability of response to salvage radiation therapy among patients with refractory or relapsed aggressive non-Hodgkin lymphoma. | PURPOSE: To evaluate the response rate (RR) and time to local recurrence (TTLR) among patients who received salvage radiation therapy for relapsed or refractory aggressive non-Hodgkin lymphoma (NHL) and investigate whether RR and TTLR differed according to disease characteristics.METHODS AND MATERIALS: A retrospective ... | ['Antibodies, Monoclonal, Murine-Derived', 'Antineoplastic Combined Chemotherapy Protocols', 'Cyclophosphamide', 'Disease-Free Survival', 'Doxorubicin', 'Female', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Palliative Care', 'Prednisolone', 'Prednisone', 'Radiotherapy Dosage... | 25,835,625 | [['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.19... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Prospective observational study on the incidence of medication errors during simulated resuscitation in a paediatric emergency department. | OBJECTIVES: To characterise the incidence and nature of medication errors during paediatric resuscitations.DESIGN: A prospective observational study of simulated emergencies.SETTING: Emergency department of a tertiary paediatric hospital.PARTICIPANTS: Teams that included a clinician who commonly leads "real" resuscitat... | ['Child', 'Clinical Competence', 'Emergencies', 'Emergency Service, Hospital', 'Emergency Treatment', 'Hospitals, Pediatric', 'Humans', 'Manikins', 'Medical Staff, Hospital', 'Medication Errors', 'Prospective Studies', 'Resuscitation'] | 15,454,495 | [['M01.060.406'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E02.365'], ['N02.278.421.556.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545.129.400', 'L... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Diversity and geographic distribution of secondary endosymbiotic bacteria in natural populations of the pea aphid, Acyrthosiphon pisum. | In addition to the essential intracellular symbiotic bacterium Buchnera, several facultative endosymbiotic bacteria called collectively secondary symbionts (S-symbionts) have been identified from the pea aphid Acyrthosiphon pisum. We conducted an extensive and systematic survey of S-symbionts in Japanese local populati... | ['Animals', 'Aphids', 'DNA, Ribosomal', 'Female', 'Genetic Variation', 'Genetics, Population', 'Japan', 'Peas', 'Polymerase Chain Reaction', 'Proteobacteria', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Spiroplasma', 'Symbiosis'] | 12,296,954 | [['B01.050'], ['B01.050.500.131.617.412.165'], ['D13.444.308.475'], ['G05.365'], ['H01.158.273.343.335'], ['Z01.252.474.463', 'Z01.639.595'], ['B01.650.940.800.575.912.250.401.630'], ['E05.393.620.500'], ['B03.660'], ['D13.444.735.686.670'], ['E05.393.760.700'], ['B03.440.860.300.750.625'], ['G06.550.800', 'G16.840']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Disseminated Mycobacterium gordonae infection in a child with cystic fibrosis. | A 4-year-old girl with cystic fibrosis (CF) presented with unrelenting pyrexia commencing shortly after flushing of the central venous catheter (CVC). Mycobacterium gordonae was subsequently isolated from bronchoalveolar lavage, gastric washings, and lung biopsy. While this case most likely represents central line infe... | ['Anti-Bacterial Agents', 'Bronchoalveolar Lavage Fluid', 'Catheters, Indwelling', 'Child, Preschool', 'Cystic Fibrosis', 'Drug Therapy, Combination', 'Female', 'Fever', 'Humans', 'Mycobacterium Infections, Nontuberculous', 'Nontuberculous Mycobacteria'] | 22,028,301 | [['D27.505.954.122.085'], ['E05.927.100.500'], ['E07.132.500'], ['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E02.319.310'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.410.040.552.475'], ['B03.510.024.962.500.720', 'B03.510.460.400.410.552.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A multidisciplinary team-oriented intervention to increase guideline recommended care for high-risk prostate cancer: A stepped-wedge cluster randomised implementation trial. | BACKGROUND: This study assessed whether a theoretically conceptualised tailored intervention centred on multidisciplinary teams (MDTs) increased clinician referral behaviours in line with clinical practice guideline recommendations.METHODS: Nine hospital Sites in New South Wales (NSW), Australia with a urological MDT a... | ['Australia', 'Guideline Adherence', 'Guidelines as Topic', 'Humans', 'Male', 'New South Wales', 'Patient Care Team', 'Prostatic Neoplasms', 'Quality of Life', 'Urologists'] | 29,530,071 | [['Z01.639.100', 'Z01.678.100.373'], ['N04.761.337', 'N05.715.360.395'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['N04.590.715'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['I01.800', 'K01.75... | ['Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
siRNA delivery to CNS cells using a membrane translocation peptide. | RNA interference (RNAi) is a sequence-specific gene silencing technique that has been applied to multiple pathological conditions. In this report, we describe the generation and in vitro characterization of an RNAi-based fluorescent probe for use as a therapeutic in the setting of ischemic stroke. Probe delivery to bEn... | ['Animals', 'Astrocytes', 'Brain', 'Cell Line', 'Cell Membrane Permeability', 'Cells, Cultured', 'Endothelial Cells', 'Gene Silencing', 'Mice', 'Mice, Inbred C57BL', 'Neurons', 'Peptides', 'Protein-Tyrosine Kinases', 'RNA, Small Interfering', 'Transfection'] | 20,420,373 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['A08.186.211'], ['A11.251.210'], ['G03.143.335', 'G04.175'], ['A11.251'], ['A11.436.275'], ['G05.308.203.374'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A08.675', 'A11.671'], ['D12.64... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca(2+) signaling pathways. | INTRODUCTION: Proteinase 3 (PR3) is released from neutrophil azurophilic granules and exerts complex effects on the inflammatory process. PR3 catalyzes the degradation of a number of macromolecules, but the consequences on blood cells are less well defined. In the present study, the effect of PR3 on human platelets was... | ['Blood Platelets', 'Calcium', 'Cell Shape', 'Humans', 'Myeloblastin', 'P-Selectin', 'Platelet Activation', 'Signal Transduction', 'rho-Associated Kinases'] | 24,993,595 | [['A11.118.188', 'A15.145.229.188'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.760.530', 'D08.811.277.656.959.350.530'], ['D12.776.395.550.200.700.775', 'D12.776.395.550.625.905', 'D12.776.503.843.775', 'D12.776.543.550.200... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. | Long-term exposure to fatty acids (FA) inhibits B-cell function. We tested whether the inhibitory effects are associated with increased islet triglycerides (TG). Rat pancreatic islets were cultured for 48 hours in RPMI 1640 medium with 10% fetal calf serum (FCS) and 11 mmol/L glucose in the presence or absence of the l... | ['Animals', 'B-Lymphocytes', 'Caprylates', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Epoxy Compounds', 'Fatty Acids', 'Glucose', 'Insulin', 'Insulin Secretion', 'Islets of Langerhans', 'Male', 'Osmolar Concentration', 'Oxidation-Reduction', 'Palmitates', 'Rats', 'Rats, Sprague-Dawley', 'Time Factors', '... | 8,769,356 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D02.241.081.222', 'D10.251.122'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], ['D02.355.291.411'], ['D10.251'], ['D09.947.875.359.448'], ['D06.472.699.587.200.500.625... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Riccati-Regularized Precision Matrices for Neuroimaging. | The introduction of graph theory in neuroimaging has provided invaluable tools for the study of brain connectivity. These methods require the definition of a graph, which is typically derived by estimating the effective connectivity between brain regions through the optimization of an ill-posed inverse problem. Conside... | ['Algorithms', 'Brain', 'Connectome', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Magnetic Resonance Imaging', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 29,503,515 | [['G17.035', 'L01.224.050'], ['A08.186.211'], ['E01.370.350.578.875.500.249', 'E01.370.376.537.625.500.249', 'E05.629.875.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.825.500'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The effects of P-box substitutions in thyroid hormone receptor on DNA binding specificity. | Three "P-box" amino acids within the DNA recognition alpha-helix of members of the steroid hormone and thyroid hormone families of nuclear receptors are known to determine the identity of two of the six base pairs within the half-sites of cognate DNA elements. We introduced P-box substitutions derived from different me... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'Chlorocebus aethiops', 'Consensus Sequence', 'DNA', 'Gene Expression Regulation', 'Humans', 'Molecular Sequence Data', 'Multigene Family', 'Mutagenesis, Site-Directed', 'Protein Binding', 'Rabbits', 'Receptors, Estrogen', 'Receptors, Thyroid Hormone'... | 7,984,145 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G02.111.570.580.175'], ['D13.444.308'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Social thermoregulation in redfronted lemurs (Eulemur fulvus rufus). | Pronounced seasonality, with temperatures dropping as low as 5 degrees C during the dry season, has led to the hypothesis that Malagasy lemurs face cold stress and respond to this by inactivity and social thermoregulation, i.e. resting in tight body contact with conspecifics. Compared to anthropoids, lemur groups are c... | ['Age Factors', 'Animals', 'Body Temperature Regulation', 'Cold Temperature', 'Female', 'Lemur', 'Male', 'Seasons', 'Social Behavior', 'Stress, Physiological'] | 12,399,657 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['B01.050.150.900.649.313.988.700.508.490'], ['G01.910.645.661', 'G16.500.275.... | ['Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria. | Doxorubicin (DOX) is a highly effective chemotherapeutic used in the treatment of a broad spectrum of malignancies. However, clinical use of DOX is highly limited by cumulative and irreversible cardiomyopathy that occurs following DOX treatment. The pathogenesis of DOX-induced cardiac muscle dysfunction is complex. How... | ['Animals', 'Antineoplastic Agents', 'Doxorubicin', 'Female', 'Mitochondria', 'Rats, Sprague-Dawley'] | 27,832,997 | [['B01.050'], ['D27.505.954.248'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trypanosoma cruzi: alpha-2-macroglobulin regulates host cell apoptosis induced by the parasite infection in vitro. | A2M is a broad spectrum proteinase inhibitor and cytokine carrier, besides presenting anti-apoptotic activity through the binding to its receptor, LRP. During Trypanosoma cruzi infection, apoptosis of host cells and intracellular parasites is commonly observed both in vivo and in vitro. Since plasma as well as tissue A... | ['Animals', 'Apoptosis', 'DNA Fragmentation', 'Humans', 'In Situ Nick-End Labeling', 'LDL-Receptor Related Proteins', 'Macrophages, Peritoneal', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Myocytes, Cardiac', 'Trypanosoma cruzi', 'alpha-Macroglobulins'] | 18,028,912 | [['B01.050'], ['G04.146.954.035'], ['G05.200.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.475'], ['D12.776.526', 'D12.776.543.750.710.450.500'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630', 'A15.382.680.397.630'], ['B01.050.150.900.649.313.992.635.505.500'], ['B0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An intermediate sFlt-1/PlGF ratio indicates an increased risk for adverse pregnancy outcome. | OBJECTIVE: The sFlt-1/PlGF ratio is a valid marker in diagnosing or excluding preeclampsia. The currently used cut offs frame an intermediate zone of 33-85 (<340 weeks) or 33-110 (?340 weeks), respectively. In this study we sought to evaluate the relevance of an intermediate sFlt-1/PlGF ratio for the clinical pregnancy... | ['Adult', 'Biomarkers', 'Female', 'Germany', 'Humans', 'Placenta Growth Factor', 'Pre-Eclampsia', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Outcome', 'Prenatal Diagnosis', 'Retrospective Studies', 'Risk Factors', 'Vascular Endothelial Growth Factor Receptor-1'] | 29,153,672 | [['M01.060.116'], ['D23.101'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.100.800.100', 'D12.776.780.551'], ['C13.703.395.249'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['E01.370.378.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Biosynthesis, post-translation modification, and functional characterization of Drm/Gremlin. | Down-regulated by mos (Drm)/Gremlin is a highly conserved protein whose properties and expression pattern suggest a role in early development, tissue-specific differentiation, and cell transformation. We have investigated the biosynthesis and processing of Drm expressed endogenously in rat fibroblasts or overexpressed ... | ['Animals', 'Base Sequence', 'Bone Morphogenetic Protein 4', 'Bone Morphogenetic Proteins', 'Cytokines', 'Glycosylation', 'Membrane Glycoproteins', 'Molecular Sequence Data', 'Protein Binding', 'Protein Isoforms', 'Protein Processing, Post-Translational', 'Proteins', 'Rats', 'Recombinant Proteins'] | 10,722,723 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.644.276.954.200.400', 'D12.776.467.942.200.400', 'D23.529.942.200.400'], ['D12.644.276.954.200', 'D12.776.467.942.200', 'D23.529.942.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G02.111.158.812', 'G02.607.299', 'G03.191.81... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synthesis, physicochemical characterization, and cytocompatibility of bioresorbable, dual-gelling injectable hydrogels. | Injectable, dual-gelling hydrogels were successfully developed through the combination of physical thermogellation at 37 °C and favorable amine:epoxy chemical cross-linking. Poly(N-isopropylacrylamide)-based thermogelling macromers with a hydrolyzable lactone ring and epoxy pendant groups and a biodegradable diamine-fu... | ['Absorption', 'Animals', 'Biological Availability', 'Cell Line', 'Hydrogels', 'Injections', 'Rats'] | 24,320,599 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['A11.251.210'], ['D20.280.320.375', 'D26.255.165.320.375'], ['E02.319.267.530'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Systemic blood pressure after stent management for arch coarctation implications for clinical care. | OBJECTIVES: The goal of this study was to prospectively assess blood pressure (BP) and echocardiographic parameters to delineate the incidence and nature of the hypertension burden in this cohort.BACKGROUND: Few data are available on the long-term outcomes of aortic stenting.METHODS: Thirty-one patients with successful... | ['Adolescent', 'Adult', 'Aortic Coarctation', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Child', 'Echocardiography', 'Endovascular Procedures', 'Exercise Test', 'Female', 'Humans', 'Hypertension', 'Incidence', 'Male', 'Ontario', 'Predictive Value of Tests', 'Prospective Studies', 'Recurrence', 'Risk Fa... | 23,428,013 | [['M01.060.057'], ['M01.060.116'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['M01.060.406'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E04.100.814.529', 'E04.502.382'], ['E01.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Medical emergencies in dental practice and choice of emergency drugs and equipment: a survey of Australian dentists. | This is a report of a postal questionnaire survey of 1250 general dental practitioners regarding occurrence of medical emergencies and their choice of emergency drugs and equipment. The response rate was 65 per cent and the results showed that about one in seven practitioners had had to resuscitate a patient. The most ... | ['Anesthetics, Local', 'Angina Pectoris', 'Australia', 'Cardiopulmonary Resuscitation', 'Clinical Competence', 'Dental Care', 'Dentists', 'Emergencies', 'Epilepsy, Tonic-Clonic', 'Epinephrine', 'Equipment and Supplies', 'General Practice, Dental', 'Humans', 'Hypoglycemia', 'Incidence', 'Oxygen', 'Pharmaceutical Prepara... | 9,153,837 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['Z01.639.100', 'Z01.678.100.373'], ['E02.365.647.110'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E06.170', 'N02.421.240.190'], ['M01.526.485.330', 'N02.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
AHIMA provides testimony on coding/classification issues pertaining to HIPAA (Health Insurance Portability and Accountability Act of 1996) implementation. | In summary, AHIMA has identified the following key issues: Uniformity and consistency must be required of all health-care organization, payers, and other data users. A central authority, comprised of representatives from the public and private sector, should be created to ensure compliance with and enforcement of codin... | ['Abstracting and Indexing', 'Career Mobility', 'Computer Security', 'Disease', 'Health Benefit Plans, Employee', 'Humans', 'Insurance Claim Reporting', 'Medical Records', 'Organizational Policy', 'United States'] | 10,168,983 | [['L01.453.245.100'], ['N01.824.245.175', 'N01.824.547.330'], ['L01.224.134', 'N04.452.910.200'], ['C23.550.288'], ['N01.824.417.700.325', 'N03.219.521.576.343.290', 'N04.452.677.800.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.210'], ['E05.318.308.940.968', 'N04.452.859.564', 'N05.715.360.... | ['Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin. | Surface plasmon resonance has been used to study the interaction between the subunits composing protein kinase CK2 (two catalytic, alpha-subunits, and two regulatory, beta-subunits), as well as the interaction of each subunit with two types of protein substrates, casein, the phosphorylation of which is activated by the... | ['Binding Sites', 'Calmodulin', 'Casein Kinase II', 'Caseins', 'Cell Division', 'Crystallography, X-Ray', 'Dimerization', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Polylysine', 'Protein Binding', 'Protein Structure, Tertiary', 'Protein-Serine-Threonine Kinases', 'Recombinant Proteins', 'Surface Plasmon Resonan... | 11,827,172 | [['G02.111.570.120'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D08.811.913.696.620.682.700.140.600', 'D12.776.476.150.600'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.196.309.742.225'], ['G02.206', ... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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