Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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The physiological and ventilatory responses to repeated 60 s sprints following sodium citrate ingestion. | This study examined the influence of sodium citrate on changes in selected blood, ventilatory and performance variables in response to intermittent sprint exercise. Eight moderately active male students completed three tests over a 6 day experimental period. The first test involved incremental exercise to determine VO2... | ['Adolescent', 'Adult', 'Alkalosis', 'Bicarbonates', 'Calcium Carbonate', 'Carbon Dioxide', 'Citrates', 'Citric Acid', 'Double-Blind Method', 'Exercise Test', 'Humans', 'Hydrogen-Ion Concentration', 'Lactates', 'Male', 'Muscle, Skeletal', 'Nausea', 'Oxygen Consumption', 'Physical Exertion', 'Placebos', 'Psychomotor Per... | 7,799,476 | [['M01.060.057'], ['M01.060.116'], ['C18.452.076.354'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D02.241.081.901.434'], ['D02.241.081.901.434.249'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Ultrastructural analysis of hippocampal neuropil from the connectomics perspective. | Complete reconstructions of vertebrate neuronal circuits on the synaptic level require new approaches. Here, serial section transmission electron microscopy was automated to densely reconstruct four volumes, totaling 670 ìm(3), from the rat hippocampus as proving grounds to determine when axo-dendritic proximities pred... | ['Animals', 'Animals, Newborn', 'Axons', 'Dendrites', 'Electronic Data Processing', 'Hippocampus', 'In Vitro Techniques', 'Male', 'Microscopy, Electron, Transmission', 'Neuropil', 'Rats', 'Rats, Long-Evans', 'Synapses'] | 20,869,597 | [['B01.050'], ['B01.050.050.282'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['L01.224.085'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E05.481'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['A08.637.500', 'A08.6... | ['Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
FLAG tagging by CuAAC and nanogram-scale purification of the target protein for a bioactive metabolite involved in circadian rhythmic leaf movement in Leguminosae. | We report a stepwise FLAG-tagging strategy for the purification of target proteins for bioactive metabolites. This method realizes the microscale purification and identification of target protein from as few as 1 x 10(5) differentiated cells. Using this method, we isolated and identified MetE as a cytosolic target prot... | ['Alkynes', 'Amino Acid Sequence', 'Azides', 'Circadian Rhythm', 'Fabaceae', 'Molecular Sequence Data', 'Plant Leaves', 'Plant Proteins'] | 20,066,328 | [['D02.455.326.397'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D01.625.100', 'D02.159'], ['G07.180.562.190'], ['B01.650.940.800.575.912.250.401'], ['L01.453.245.667'], ['A18.024.812'], ['D12.776.765']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of galactosyltransferase activity by cacodylate buffer. | Cacodylate buffer, frequently used in the assay of galactosyltransferase, causes inhibition of enzyme purified from human pleural effusion. The inhibition is reflected by an increase in the Km (UDP-galactose) and a decrease in Vmax and cannot be reversed by the addition of 2-mercaptoethanol. It is suggested that altern... | ['Arsenicals', 'Buffers', 'Cacodylic Acid', 'Galactosyltransferases', 'Humans', 'Pleural Effusion'] | 3,131,051 | [['D01.075', 'D02.129'], ['D27.720.470.280'], ['D02.129.100'], ['D08.811.913.400.450.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.652']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Back to nature. | I am going to draw your attention to natural systems--what nature has spent millions of years perfecting--and suggest that nature has the road map for health care's future even if we have a little less time to work on it. | ['Cooperative Behavior', 'Environment', 'Insurance Coverage', 'Medicaid', 'Medicare', 'Michigan', 'Rural Health Services', 'United States'] | 10,344,821 | [['F01.145.813.115'], ['G16.500.275', 'N06.230'], ['N03.219.521.576.265'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['N02.421.816'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Methylation of genomes and genes at the invertebrate-vertebrate boundary. | Patterns of DNA methylation in animal genomes are known to vary from an apparent absence of modified bases, via methylation of a minor fraction of the genome, to genome-wide methylation. Representative genomes from 10 invertebrate phyla comprise predominantly nonmethylated DNA and (usually but not always) a minor fract... | ['Animals', 'DNA Methylation', 'DNA, Ribosomal', 'Genes', 'Genome', 'Invertebrates', 'Molecular Sequence Data', 'RNA, Ribosomal, 18S', 'RNA, Ribosomal, 28S', 'Vertebrates'] | 9,032,274 | [['B01.050'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D13.444.308.475'], ['G05.360.340.024.340'], ['G05.360.340'], ['B01.050.500'], ['L01.453.245.667'], ['D13.444.735.686.675'], ['D13.444.735.686.690'], ['B01.050.150.900']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
In vitro sensitivity of fresh ovarian carcinoma specimens to CPT-11 (irinotecan). | OBJECTIVE: Irinotecan (CPT-11) is a DNA topoisomerase I inhibitor which has shown activity in vitro against several cancer cell lines and some promising clinical responses in phase I and II trials in various solid tumors. The cytotoxicity of CPT-11 on human ovarian epithelial malignancies was tested in vitro utilizing ... | ['Adenocarcinoma', 'Antineoplastic Agents, Phytogenic', 'Camptothecin', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Female', 'Flow Cytometry', 'Humans', 'In Vitro Techniques', 'Irinotecan', 'Ovarian Neoplasms', 'Topoisomerase I Inhibitors'] | 10,021,292 | [['C04.557.470.200.025'], ['D27.505.954.248.179'], ['D03.132.151'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.64... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Change in the number of informal helpers of frail older persons. | Little is known of the extent to which helper networks of frail older persons change over time and what factors are associated with change. Few national estimates of the scope of change exist to aid policy planners. This study provides national estimates of changes in the size of the informal helping network of frail e... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Caregivers', 'Female', 'Frail Elderly', 'Humans', 'Longitudinal Studies', 'Male', 'United States'] | 8,041,861 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['M01.060.116.100.540'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Postoperative complications associated with dural substitutes in suboccipital craniotomies. | OBJECTIVE: Dural replacements are used in cranial surgery when primary closure of native dura is not possible. The goal is to recreate a watertight barrier to prevent cerebrospinal fluid leakage with few associated complications. We reviewed a single-institution experience with a variety of dural substitutes in posteri... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Biocompatible Materials', 'Cattle', 'Child', 'Child, Preschool', 'Collagen', 'Craniotomy', 'Dermis', 'Dura Mater', 'Female', 'Humans', 'Infant', 'Male', 'Membranes, Artificial', 'Middle Aged', 'Occipital Bone', 'Postoperative Complications', 'Retrospectiv... | 19,240,570 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.150.900.649.313.500.380.271'], ['M01.060.406'], ['M01.060.406.448'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E04.525.190'], ['A17.815.180'], ['A08.186.566.395'... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Usefulness of contrast perfusion echocardiography for differential diagnosis of cardiac masses. | The aim of this study was to assess the usefulness of contrast perfusion echocardiography in the differential diagnosis of different types of cardiac masses. Conventional echocardiography and contrast perfusion echocardiography were performed in 72 patients with cardiac masses. The degree of contrast enhancement of the... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Contrast Media', 'Diagnosis, Differential', 'Echocardiography', 'Female', 'Heart Neoplasms', 'Humans', 'Image Enhancement', 'Male', 'Middle Aged', 'Myocardial Perfusion Imaging', 'Observer Variation', 'Reproducibility of Results', 'Sensitivity and Specifici... | 26,087,885 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Long-term effects of single-dose metrifonate on the control of urinary schistosomiasis in an endemic area. | During 1989 a survey for urinary schistosomiasis was carried out in children attending Kanhukamwe primary school where, 5 years previously, infected children had been treated with a single dose of metrifonate. The treatment programme had been supplemented by improvements in water supply and sanitation, but no molluscic... | ['Adolescent', 'Child', 'Child, Preschool', 'Feces', 'Humans', 'Parasite Egg Count', 'Schistosomiasis haematobia', 'Specimen Handling', 'Trichlorfon', 'Zimbabwe'] | 1,904,945 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.932.600', 'E05.200.932.600'], ['C01.610.335.865.859.427', 'C01.915.775', 'C01.920.922.427', 'C12.777.892.775', 'C13.351.968.892.775'], ['E01.370.225.998', 'E05.200.998'], ['D02.705.429.937... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer. | Numerous studies have demonstrated that circulating microparticles (MPs) play important roles in a variety of diseases (e.g., atherosclerosis, hypertension, and diabetes), but the association between circulating MPs and oral squamous cell carcinoma (OSCC) remains largely unknown. In the present study, the circulating p... | ['Blood Coagulation', 'Blood Platelets', 'Carcinoma, Squamous Cell', 'Cell-Derived Microparticles', 'Cytokines', 'Female', 'Fibrinogen', 'Flow Cytometry', 'Humans', 'Interleukin-6', 'Male', 'Mouth Neoplasms', 'Neoplasm Staging', 'Odontogenic Tumors', 'Tumor Necrosis Factor-alpha'] | 26,124,218 | [['G09.188.390.150'], ['A11.118.188', 'A15.145.229.188'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.284.295.588.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of gestational nicotine exposure on intrauterine and fetal infection in a rodent model. | We investigated the interaction between prenatal nicotine exposure and intrauterine infection using established rat models. Beginning at gestation day (GD) 6, dams were continuously infused with either saline or 6 mg/kg/day nicotine (Nic). At GD 14, dams received either sterile broth or 105 colony-forming units Mycopla... | ['Amniotic Fluid', 'Animals', 'Bacterial Load', 'Colony Count, Microbial', 'Cytokines', 'Female', 'Fetal Diseases', 'Inflammation', 'Mycoplasma Infections', 'Mycoplasma pulmonis', 'Nicotine', 'Nicotinic Agonists', 'Placenta', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Rats', 'Rats, Sprague-Dawley'] | 28,419,180 | [['A12.098', 'A16.378.149'], ['B01.050'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C13.703.277', 'C16.300'], ['C23.550.470'], ['C01.150.252.400... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rational-emotive therapy and depression: a clinical case study. | Rational-emotive group and bibliotherapy were used to treat a depressed patient in a clinical setting. Psychological test data document a dramatic improvement. It is suggested that rational-emotive therapy may prove efficacious for the treatment of some depressed patients in clinical settings. | ['Adult', 'Depressive Disorder', 'Humans', 'Male', 'Psychotherapy', 'Psychotherapy, Group', 'Psychotherapy, Rational-Emotive', 'Suicide, Attempted'] | 7,208,230 | [['M01.060.116'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.754'], ['F04.754.864.581'], ['F04.754.785'], ['F01.145.126.980.875.600', 'I01.880.735.856.600']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Spherulite crystals in synovial tissue of a patient with recurrent monoarthritis. | Frozen, unstained sections of synovial tissue of a 38-year-old man with recurrent monoarthritis and hyperuricemia were studied. Negatively birefringent crystals in a spherulite form were detected by using a compensated polarized light microscope. It is postulated that in some cases of gout the first stage of crystalliz... | ['Adult', 'Arthritis', 'Biopsy', 'Birefringence', 'Crystallization', 'Gout', 'Humans', 'Male', 'Microscopy, Fluorescence', 'Synovial Membrane'] | 6,532,612 | [['M01.060.116'], ['C05.550.114'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G01.590.080'], ['E05.196.300', 'G02.171'], ['C05.550.114.423', 'C05.550.354.500', 'C05.799.414', 'C16.320.565.798.368', 'C18.452.648.798.368... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons. | Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral striatal medium spiny neurons (MSNs) is well-docume... | ['Animals', 'Corpus Striatum', 'Dendritic Spines', 'Male', 'Neostriatum', 'Neuronal Plasticity', 'Nicotine', 'Rats, Sprague-Dawley', 'Receptors, Dopamine D1'] | 28,576,726 | [['B01.050'], ['A08.186.211.200.885.287.249.487'], ['A08.675.256.200', 'A11.284.180.225.169', 'A11.671.240.169'], ['A08.186.211.200.885.287.249.487.550'], ['G11.561.638'], ['D03.132.760.570', 'D03.383.725.518'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.670.300.400.400', 'D12.776.543.750.695.15... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biomimetics of human movement: functional or aesthetic? | How should robotic or prosthetic arms be programmed to move? Copying human smooth movements is popular in synthetic systems, but what does this really achieve? We cannot address these biomimetic issues without a deep understanding of why natural movements are so stereotyped. In this article, we distinguish between 'fun... | ['Biomimetics', 'Esthetics', 'Humans', 'Models, Biological', 'Movement', 'Robotics'] | 19,567,935 | [['H01.158.550.100', 'J01.897.120.100'], ['F02.463.785.477', 'K01.752.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G07.568', 'G11.427.410'], ['H01.671.293.643', 'J01.897.104.834', 'L01.224.050.375.630']] | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Limitation of temporary vascular occlusion during aneurysm surgery. Study by intraoperative monitoring of cortical blood flow. | The limitations of temporary vascular occlusion during aneurysm surgery as evidenced by the postoperative ischemic symptoms in relation to cerebral blood flow were studied. Six of the 39 cases had postoperative ischemic neurological deficit. When residual cerebral blood flow was below 15 mL/min/100 g, transient symptom... | ['Adult', 'Aged', 'Cerebrovascular Circulation', 'Constriction', 'Electroencephalography', 'Female', 'Humans', 'Intracranial Aneurysm', 'Ischemic Attack, Transient', 'Male', 'Middle Aged', 'Monitoring, Intraoperative', 'Postoperative Complications', 'Rupture, Spontaneous', 'Time Factors', 'Vascular Surgical Procedures'... | 1,759,185 | [['M01.060.116'], ['M01.060.116.100'], ['G09.330.100.159'], ['E05.225'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600', 'C14.907.055.635', 'C14.907.253.560.300'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['M01.060.116.630'], ['E01.370.520.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
á-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. | Covalently attached peptide dendrimers can enhance binding affinity and functional activity. Homogenous di- and tetravalent dendrimers incorporating the á7-nicotinic receptor blocker á-conotoxin ImI (á-ImI) with polyethylene glycol spacers were designed and synthesized via a copper-catalyzed azide-alkyne cycloaddition ... | ['Binding Sites', 'Cell Line', 'Chemistry Techniques, Synthetic', 'Circular Dichroism', 'Conotoxins', 'Cycloaddition Reaction', 'Dendrimers', 'Dose-Response Relationship, Drug', 'Electrophysiology', 'Humans', 'Inhibitory Concentration 50', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Surface Plasmon Resonance', 'alp... | 25,710,197 | [['G02.111.570.120'], ['A11.251.210'], ['E05.197', 'J01.897.836.249'], ['E05.196.867.151'], ['D20.888.590.162', 'D23.946.580.590.162', 'D23.946.833.590.162'], ['E05.197.406', 'J01.897.836.249.374'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['G07.690.773.875', 'G07.690.936.500'], ['H01.158.344.528'... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Stability and stabilization of Fusobacterium necrophorum hemolysin. | The stability and stabilization of the hemolytic activity of Fusobacterium necrophorum subsp. necrophorum and Fusobacterium necrophorum subsp. funduliforme were monitored over a period of four weeks using culture supernatants. The hemolytic activity was completely lost after one week at room temperature and 37 degrees ... | ['Albumins', 'Cysteine', 'Excipients', 'Fusobacterium necrophorum', 'Hemolysin Proteins', 'Polysorbates', 'Temperature'] | 8,810,016 | [['D12.776.034'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D26.650.700.419', 'D27.720.744.770.419'], ['B03.370.250.400', 'B03.440.425.410.420.400'], ['D12.776.543.695.444'], ['D02.033.455.250.700.690', 'D05.750.741.700', 'D25.720.741.700', 'J01.637.051.720.741.700'], ['G01.906.595... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Unilateral laparoscopic adrenalectomy followed by contralateral retroperitoneoscopic partial adrenalectomy in a patient with multiple endocrine neoplasia type 2a syndrome. | We report the first patient who had bilateral pheochromocytoma associated with multiple endocrine neoplasia type 2a syndrome (MEN 2a) and underwent unilateral laparoscopic adrenalectomy followed by contralateral retroperitoneoscopic partial adrenalectomy 2 years later. The postoperative course was uneventful both times... | ['Adrenal Gland Neoplasms', 'Adrenalectomy', 'Carcinoma, Medullary', 'Female', 'Follow-Up Studies', 'Humans', 'Laparoscopy', 'Magnetic Resonance Imaging', 'Middle Aged', 'Multiple Endocrine Neoplasia Type 2a', 'Pheochromocytoma', 'Reoperation', 'Retroperitoneal Space', 'Syndrome', 'Thyroid Neoplasms', 'Thyroidectomy'] | 10,213,103 | [['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['E04.270.115'], ['C04.557.465.625.650.240.315', 'C04.557.470.200.025.370.315', 'C04.557.470.615.315', 'C04.557.580.625.650.240.315'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Midlife homocysteine and late-life dementia in women. A prospective population study. | Elevated serum total homocysteine (tHcy) is an established risk factor for cardiovascular disease. Its role in dementia is still controversial, and no study has examined the role of midlife tHcy, or reports longer than 8 years of follow-up. We examined the relation between midlife tHcy and late-life dementia in women f... | ['Adult', 'Aging', 'Community Health Planning', 'Confidence Intervals', 'Dementia', 'Female', 'Homocysteine', 'Humans', 'Longitudinal Studies', 'Middle Aged', 'Neurologic Examination', 'Proportional Hazards Models', 'Psychiatric Status Rating Scales', 'Retrospective Studies', 'Survival Analysis'] | 19,342,123 | [['M01.060.116'], ['G07.345.124'], ['N03.349.650.185'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['C10.228.140.380', 'F03.615.400'], ['D02.886.030.498', 'D12.125.166.498'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The start of caring for an elderly dependent family member: a qualitative metasynthesis. | BACKGROUND: The family often takes care of an elderly person who suddenly becomes dependent. This greatly affects different aspects of the caregivers' lives. The aim of this study is to explore the initial experiences, during the first year of care, of persons who suddenly become caregivers for elderly dependent relati... | ['Aged', 'Aged, 80 and over', 'Caregivers', 'Family', 'Female', 'Frail Elderly', 'Humans', 'Male', 'Qualitative Research'] | 30,253,750 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F01.829.263', 'I01.880.853.150'], ['M01.060.116.100.540'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.241.850']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Oculomotor evidence for top-down control following the initial saccade. | The goal of the current study was to investigate how salience-driven and goal-driven processes unfold during visual search over multiple eye movements. Eye movements were recorded while observers searched for a target, which was located on (Experiment 1) or defined as (Experiment 2) a specific orientation singleton. Th... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Female', 'Goals', 'Humans', 'Male', 'Oculomotor Nerve', 'Photic Stimulation', 'Saccades', 'Young Adult'] | 21,931,603 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.050.050.650', 'A08.800.050.600.475', 'A08.800.800.060.650', 'A08.800.800.120.600'], ['E05.723.729'], ['G14.350.500'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of reducing the number of items of the Oral Health Impact Profile on responsiveness, validity and reliability in edentulous populations. | BACKGROUND: The 49-item Oral Health Impact Profile (OHIP) has shown strong responsiveness, reliability and validity. However, the large number of items included may limit its use in clinical trials, clinical practice and surveys.OBJECTIVE: The main objective of this study is to assess the effect of reducing the number ... | ['Adult', 'Aged', 'Dental Health Surveys', 'Dental Prosthesis, Implant-Supported', 'Denture, Complete, Lower', 'Denture, Overlay', 'Humans', 'Middle Aged', 'Mouth, Edentulous', 'Oral Health', 'Quality of Life', 'ROC Curve', 'Reproducibility of Results', 'Sickness Impact Profile', 'Surveys and Questionnaires'] | 18,205,635 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.308.980.438.300', 'E06.208', 'N05.715.360.300.800.438.300', 'N06.850.520.308.980.438.300', 'N06.890.160'], ['E06.780.346.706', 'E07.695.190.185'], ['E06.780.346.760.775.379', 'E07.695.190.200.205.210'], ['E06.780.346.760.887', 'E07.695.190.200.215'], ['B01.050.150.900.64... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The conceptualization, measurement, and validation of transient mechanical birth trauma. | An index of transient mechanical birth trauma (TMBT), consisting of the presence or absence of molding, cephalohematoma, subconjunctival hemorrhage, body bruising, facial bruising, petechiae, forceps marks, diminished arm movements, and sensitivity to sudden position changes, was measured on a convenience sample of 196... | ['Birth Injuries', 'Clinical Nursing Research', 'Humans', 'Infant, Newborn', 'Maternal-Child Nursing', 'Neonatal Nursing', 'Nursing Assessment', 'Reproducibility of Results', 'Trauma Severity Indices'] | 11,276,622 | [['C16.614.131', 'C26.141'], ['H01.770.644.145.390.234', 'H02.478.395.234', 'N04.590.233.508.613.234'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['H02.478.676.390', 'N02.421.533.460'], ['H02.478.676.390.600', 'H02.478.676.631.600', 'N02.421.533.460.600', 'N02.421.533.691.600'], ['N04.590.23... | ['Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Design for a slender shaft glass micropipette. | A method for the construction of long, slender shaft glass micropipettes is described. The diameter of the pipettes is comparable to metal microelectrodes that are used when multiple penetrations are required to record from neurons in relatively small targets located deep within brain tissue. The advantages of the slen... | ['Animals', 'Brain Mapping', 'Columbidae', 'Electrophysiology', 'Glass', 'Neurophysiology', 'Saimiri', 'Vestibular Nerve', 'Vestibular Nuclei'] | 6,668,954 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.248.165.150'], ['H01.158.344.528', 'H01.158.782.236'], ['J01.637.437'], ['H01.158.610.268', 'H01.158.782.562'], ['B01.050.150.900.649.313.988.400.600.150.710.710'], ['A08.800.800.120.910.900'], ['A08.186.211.132.8... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Erwinia chrysanthemi iron metabolism: the unexpected implication of the inner membrane platform within the type II secretion system. | The type II secretion (T2S) system is an essential device for Erwinia chrysanthemi virulence. Previously, we reported the key role of the OutF protein in forming, along with OutELM, an inner membrane platform in the Out T2S system. Here, we report that OutF copurified with five proteins identified by matrix-assisted la... | ['Bacterial Outer Membrane Proteins', 'Bacterial Proteins', 'Carrier Proteins', 'Chromatography, Affinity', 'Citrates', 'Dickeya chrysanthemi', 'Dipeptides', 'Electrophoresis, Polyacrylamide Gel', 'Genotype', 'Iron', 'Ketoglutaric Acids', 'Mutation', 'Oxidative Stress', 'Phosphate-Binding Proteins', 'Protein Binding', ... | 18,978,048 | [['D12.776.097.120', 'D12.776.543.100'], ['D12.776.097'], ['D12.776.157'], ['E05.196.181.400.170'], ['D02.241.081.901.434'], ['B03.660.250.139.500'], ['D12.644.456.345'], ['E05.196.401.402', 'E05.301.300.319'], ['G05.380'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D02.241.081.337.351.502', 'D02.241.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation. | The objective of this report is to discuss the potential for normal hormone regulation and application of chronic phosphodiesterase type 5 inhibition for the management of recurrent ischemic priapism. A 64-year-old man presented with refractory priapism treated with antiandrogen therapy. He was transitioned to and well... | ['Androgen Antagonists', 'Anilides', 'Humans', 'Male', 'Nitriles', 'Penis', 'Phosphodiesterase 5 Inhibitors', 'Piperazines', 'Priapism', 'Purines', 'Recurrence', 'Sildenafil Citrate', 'Sulfones', 'Tosyl Compounds'] | 21,127,306 | [['D06.347.065', 'D27.505.696.399.450.065'], ['D02.065.199', 'D02.092.146.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.626'], ['A05.360.444.492'], ['D27.505.519.389.735.500'], ['D03.383.606'], ['C12.294.494.786'], ['D03.633.100.759'], ['C23.550.291.937'], ['D02.065.884.675', 'D02.886.590.700.675', 'D03... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of endogenous digitalis-like factor on endothelin secretion from bovine endothelial cells. | We have recently isolated two endogenous digitalis-like factors (EDLFs) from human urine. The polar EDLF (ouabain-displacing compound 1; ODC-1) fulfills the criteria for the putative natriuretic and vasoactive digitalis-like factor. In this study, we examined the effects of ODC-1 and ouabain on endothelin-1 (ET-1) secr... | ['Animals', 'Cardenolides', 'Cattle', 'Cells, Cultured', 'Digoxin', 'Endothelins', 'Endothelium, Vascular', 'Erythrocytes', 'Humans', 'In Vitro Techniques', 'Ouabain', 'Radioimmunoassay', 'Saponins', 'Sodium-Potassium-Exchanging ATPase'] | 1,725,318 | [['B01.050'], ['D04.210.500.155.580.130'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D04.210.500.155.580.130.500.436', 'D04.210.500.155.580.130.688', 'D09.408.180.261.436'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['A07.015.700.500', 'A10.272.491.355'], ['A11.118.290', 'A11.443.240', 'A15.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer. | PURPOSE: To assess the maximum well-tolerated dose (MWTD), dose limiting toxicity (DLT), pharmacokinetics (PK) and pharmacodynamics of zibotentan, a novel specific endothelin-A receptor antagonist, in patients with metastatic prostate cancer.METHODS: Patients with metastatic, castrate-resistant prostate cancer (CRPC) w... | ['Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Castration', 'Dose-Response Relationship, Drug', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Prostatic Neoplasms', 'Pyrrolidines', 'Time Factors', 'Treatment Outcome'] | 19,763,400 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['E04.270.282', 'E04.950.165'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.650', 'C23.550.727.650'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Buccolinguofacial apraxia--a probably psychogenic speech and deglutition disorder]. | Difficulties in swallowing and speaking may in rare cases be due to buccolinguofacial apraxia, which usually results from lesions of the frontal operculum--mostly on the left side--or of connections to and from it. Two cases with this disorder, probably due to a multiple sclerosis, are presented and the differential di... | ['Adult', 'Apraxias', 'Cerebral Cortex', 'Cheek', 'Deglutition Disorders', 'Diagnosis, Differential', 'Face', 'Female', 'Humans', 'Multiple Sclerosis', 'Speech Disorders', 'Tongue'] | 3,423,775 | [['M01.060.116'], ['C10.597.606.881.350', 'C23.888.592.604.882.350', 'F01.700.875.350'], ['A08.186.211.200.885.287.500'], ['A01.456.505.173', 'A14.194'], ['C06.405.117.119', 'C09.775.174'], ['E01.171'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement. | Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a poor prognosis, therefore development of novel effective therapies is urgent. In the present study, we investigated the therapeutic efficacy of vandetanib (ZD6474), an inhibitor of VEGFR-2, EGFR and RET tyrosine kinases, in an orthotopic model of M... | ['Angiogenesis Inhibitors', 'Animals', 'Apoptosis', 'Base Sequence', 'Cell Line, Tumor', 'Cell Proliferation', 'ErbB Receptors', 'Gefitinib', 'Gene Rearrangement', 'Humans', 'Male', 'Mesothelioma', 'Mice', 'Mice, SCID', 'Molecular Sequence Data', 'Neoplasm Transplantation', 'Neovascularization, Pathologic', 'Piperidine... | 18,364,248 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
IgA nephropathy in association with Crohn's disease. | BACKGROUND: Urological complications of inflammatory bowel disease are seen in up to 25% of patients, but renal parenchymal disease is rarely reported.CASE REPORT: The authors describe a case of a 29-year-old man with clinical and radiological features of ileocaecal Crohn's disease. He had previously been investigated ... | ['Adult', 'Colectomy', 'Crohn Disease', 'Glomerulonephritis, IGA', 'Humans', 'Male'] | 15,668,785 | [['M01.060.116'], ['E04.210.219'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['C12.777.419.570.363.608', 'C13.351.968.419.570.363.608', 'C20.111.525'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model. | Interleukin (IL)-12 and IL-18 are secreted by myeloid cells activated with adjuvants such as Bacillus Calmette-Gu?rin (BCG) cell wall. They induce T-helper 1 polarization in the host immune system and upregulate production of lymphocyte interferon-gamma, which leads to the induction of an antitumor gene program. It has... | ['Animals', 'Carcinoma, Hepatocellular', 'Disease Models, Animal', 'Guinea Pigs', 'Humans', 'Immunotherapy', 'Interleukin-12', 'Interleukin-18', 'Liver Neoplasms', 'Recombinant Proteins', 'Toll-Like Receptors'] | 17,888,032 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['D12.644.276.374.465.512', 'D12.776.467.374.465.512', 'D23.52... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Marfanoid habitus with abnormal situs. | Marfanoid habitus suggests abnormal microfibril formation, whereas a situs ambiguus or situs inversus phenotype points to defective left-right axis determination. The concurrence of these two abnormalities has been reported only once in the literature. We report a similar phenotype in two unrelated patients. Documentat... | ['Female', 'Humans', 'Infant', 'Male', 'Marfan Syndrome', 'Situs Inversus', 'Tomography, X-Ray Computed'] | 15,150,786 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C05.116.099.674', 'C14.240.400.725', 'C14.280.400.725', 'C16.131.077.550', 'C16.131.240.400.720', 'C16.320.540', 'C17.300.500'], ['C16.131.810'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.81... | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Epidemiological analysis of norovirus infectious diarrhea outbreaks in Chongqing, China, from 2011 to 2016. | OBJECTIVE: We investigated the epidemiological characteristics of norovirus infection from 2011 to 2016 in Chongqing, China, in order to provide evidence for strategies on epidemic prevention and control.METHODS: We collected data on norovirus infectious diarrhea epidemics in 38 districts and counties, and analyzed the... | ['Adolescent', 'Caliciviridae Infections', 'Child', 'Child, Preschool', 'China', 'Diarrhea', 'Epidemics', 'Female', 'Gastroenteritis', 'Genotype', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Norovirus', 'Phylogeny', 'Seasons', 'Urban Population'] | 31,548,166 | [['M01.060.057'], ['C01.925.782.160'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['C23.888.821.214'], ['N06.850.290.200'], ['C06.405.205'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.98... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. | Drosophila peripheral nerves, similar structurally to the peripheral nerves of mammals, comprise a layer of axons and inner glia, surrounded by an outer perineurial glial layer. Although it is well established that intercellular communication occurs among cells within peripheral nerves, the signaling pathways used and ... | ['Animals', 'Base Sequence', 'Calmodulin-Binding Proteins', 'Carrier Proteins', 'Cell Division', 'Cloning, Molecular', 'DNA', 'Drosophila', 'Drosophila Proteins', 'Ether-A-Go-Go Potassium Channels', 'Genes, Insect', 'Genes, Neurofibromatosis 1', 'Humans', 'Insect Proteins', 'Membrane Transport Proteins', 'Models, Neuro... | 11,517,334 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157.142'], ['D12.776.157'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.393.220'], ['D13.444.308'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['D12.776.157.530.400.600.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The impact of medical terminology on readability of patient education materials. | Most health-related literature is written above the reading ability of the lay audience; however, no studies to date have identified the impact of medical terms on readability of health education materials. The purpose of this study was to identify whether there was a change in calculated reading levels of patient educ... | ['Comprehension', 'Educational Status', 'Humans', 'Mid-Atlantic Region', 'Pamphlets', 'Patient Education as Topic', 'Reading', 'Teaching Materials', 'Terminology as Topic'] | 17,563,283 | [['F02.463.188.357'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.500'], ['L01.178.682.707'], ['I02.233.332.500', 'N02.421.726.407.680'], ['L01.559.423.557'], ['L01.178.820'], ['L01.559.598.400']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Purification and characterization of a major endonuclease from rat liver nuclei. | A major endonuclease has been purified approximately 800-fold from rat liver nuclei using poly(A) as substrate. The enzyme had a molecular weight of about 50,000, and active fractions were obtained which contained no nucleic acid. Enzymatic activity was optimal between pH 6 and 7 and was totally dependent on the presen... | ['Animals', 'Cell Nucleus', 'Chromatography, DEAE-Cellulose', 'Chromatography, Ion Exchange', 'Deoxyribonucleases', 'Endonucleases', 'Female', 'Hydrogen-Ion Concentration', 'Kinetics', 'Liver', 'Magnesium', 'Microscopy, Electron', 'Polynucleotides', 'Rats', 'Ribonucleases', 'Structure-Activity Relationship', 'Subcellul... | 238,564 | [['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.196.181.400.383.349'], ['E05.196.181.400.383'], ['D08.811.277.352.335'], ['D08.811.277.352.355'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['E01.370.350.515.402', 'E05.595.... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Techniques of reporting disease outbreak investigations. | Effective communication of results and recommendations among veterinarians and between veterinarians and clients is an essential but often neglected component of an outbreak investigation. Although results have been traditionally related verbally, written reports are essential to minimize possible misunderstandings and... | ['Animals', 'Animals, Domestic', 'Disease Outbreaks', 'Epidemiologic Methods'] | 3,259,453 | [['B01.050'], ['B01.050.050.116'], ['N06.850.290'], ['E05.318', 'N06.850.520']] | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Complement effects of the infectivity of Plasmodium gallinaceum to Aedes aegypti mosquitoes. II. Changes in sensitivity to complement-like factors during zygote development. | During transformation into ookinetes, the zygotes of Plasmodium gallinaceum are initially resistant to lysis by heat-labile and EDTA-sensitive factors in the serum of their natural host, the chicken. Between 6 and 8 hr postgametogenesis, zygotes cultured in vitro lose their resistance to these factors. Loss of resistan... | ['Aedes', 'Animals', 'Chickens', 'Complement Pathway, Alternative', 'Complement System Proteins', 'Edetic Acid', 'Immune Sera', 'Plasmodium', 'Plasmodium gallinaceum', 'Zygote'] | 3,116,195 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G12.274.695'], ['D12.776.124.486.274'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Binding of glyceraldehyde-3-phosphate dehydrogenase to phospholipid liposomes. | The binding of glyceraldehyde-3-phosphate dehydrogenase prepared from rabbit muscle to phospholipid model membranes (liposomes) as a function of pH, ionic strength, and the influence of the binding on specific activity of the enzyme was studied. The binding decreases the specific activity of the enzyme. The binding was... | ['Animals', 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'Kinetics', 'Liposomes', 'Muscles', 'Phospholipids', 'Protein Binding', 'Rabbits'] | 698,206 | [['B01.050'], ['D08.811.682.657.163.750'], ['G01.374.661', 'G02.111.490'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A02.633', 'A10.690'], ['D10.570.755'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis. | BACKGROUND: Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. That allergy is characterized by inflammation and that the response to the decongestion test ... | ['Administration, Intranasal', 'Adult', 'Follow-Up Studies', 'Humans', 'Nasal Decongestants', 'Nasal Obstruction', 'Prospective Studies', 'Pulmonary Ventilation', 'Reproducibility of Results', 'Rhinitis, Allergic, Perennial', 'Rhinomanometry', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 18,954,509 | [['E02.319.267.120.655.500'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.954.411.793.610', 'D27.505.954.796.560'], ['C08.460.525', 'C08.618.846.185.525', 'C09.603.525'], ['E05.318.372.500.750.625'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Activation of nitric oxide synthesis in vascular smooth muscle cells and macrophages during development in spontaneously hypertensive rats. | We previously showed that the lymphocyte proliferation response was significantly suppressed in spontaneously hypertensive rats (SHR) and that this depressed response was due to excessive production of nitric oxide (NO) in macrophages and vascular smooth muscle cells (VSMC). Whether lymphocyte depression and activation... | ['Aging', 'Animals', 'Arginine', 'Blood Pressure', 'Cell Division', 'Cells, Cultured', 'Concanavalin A', 'Enzyme Inhibitors', 'Hypertension', 'Lymphocytes', 'Macrophages', 'Male', 'Muscle, Smooth, Vascular', 'Nitric Oxide', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Species Specificity', 'Spleen', 'omega-N-Methyl... | 8,722,440 | [['G07.345.124'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['D27.505.519.389'], ['C14.907.489'], ['A11.118.637... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical characteristics of patients with exercise-induced ST-segment elevation without prior myocardial infarction. | BACKGROUND: Exercise-induced ST-segment elevation is a relatively uncommon problem and occurs more frequently in patients who have had a myocardial infarction. Data is limited on the characteristics of Taiwanese patients without prior myocardial infarction who develop exercise-induced ST-segment elevation.METHODS AND R... | ['Acute Disease', 'Adult', 'Aged', 'Cohort Studies', 'Coronary Angiography', 'Coronary Circulation', 'Coronary Stenosis', 'Coronary Vasospasm', 'Coronary Vessels', 'Echocardiography', 'Electrocardiography', 'Exercise', 'Exercise Test', 'Female', 'Follow-Up Studies', 'Heart', 'Heart Function Tests', 'Hemodynamics', 'Hum... | 16,501,289 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['G09.330.100.324'], ['C14.280.647.250.285', 'C14.907.585.250.285'], ['C14.280.647.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Exposure to a lithium-paired context elicits gaping in rats: A model of anticipatory nausea. | Chemotherapy patients report anticipatory nausea and vomiting upon re-exposure to the cues previously associated with the treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed to a toxin-paired flavored solution. Here we report that rats also display gaping reactions during expo... | ['Animals', 'Antiemetics', 'Conditioning, Operant', 'Disease Models, Animal', 'Dronabinol', 'Infusions, Intravenous', 'Lithium', 'Male', 'Nausea', 'Ondansetron', 'Rats', 'Rats, Sprague-Dawley', 'Taste'] | 16,737,724 | [['B01.050'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['F02.463.425.179.509'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.455.849.090.810'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480', 'D01.552.547.290'], ['C23.88... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Episomal persistence of recombinant adenoviral vector genomes during the cell cycle in vivo. | Previously we showed that recombinant adenoviral helper-dependent (HD) vectors result in long-term transgene expression levels in vivo which slowly declined by 95% over a period of 1 year. In this study, we further establish that this was not predominantly immune mediated. To determine if cell turnover was responsible ... | ['Adenoviridae', 'Animals', 'Base Sequence', 'Cell Cycle', 'DNA Primers', 'Genetic Vectors', 'Genome, Viral', 'Mice', 'Mice, Inbred C57BL', 'Plasmids', 'Recombination, Genetic', 'Transgenes'] | 12,805,471 | [['B04.280.030'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.144'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.337'], ['G05.360.340.358.840'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Urinary diversions: A time to enrich surgical training? | OBJECTIVE: To assess the potential exposure to complex urologic procedures, specifically urinary diversion, during a gynecologic oncology fellowship.METHODS: We queried the University HealthSystem Consortium (UHC) database to determine the total number of urinary diversions performed from October 2008 to August 2012. T... | ['Academic Medical Centers', 'Female', 'Gynecology', 'Humans', 'Internship and Residency', 'Male', 'Medical Oncology', 'Urinary Diversion'] | 26,556,767 | [['N02.278.020'], ['H02.403.763.750', 'H02.403.810.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.429.515'], ['E04.950.774.852']] | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Comparable cytological features between cells processed as either wet mount or conventional cytospins. | OBJECTIVE: Microfluidics represents a novel approach for the processing of pathological biopsy specimens. It represents an enabling platform between traditional morphology-driven pathology diagnostics and future sequencing technologies. Microfluidics requires the dissociation of cells from tissue, but the evaluation of... | ['Cytodiagnosis', 'Humans', 'Microfluidic Analytical Techniques', 'Papanicolaou Test', 'Specimen Handling', 'Staining and Labeling'] | 25,040,733 | [['E01.370.225.500.384', 'E05.200.500.384', 'E05.242.384'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.588.465'], ['E01.370.225.500.384.100.422', 'E01.370.225.998.054.422', 'E04.074.422', 'E05.200.500.384.100.422', 'E05.200.998.054.422', 'E05.242.384.100.422'], ['E01.370.225.998', 'E05.200.998'], ['E01.370.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Using intravenous sedation to manage adults with neurological impairment. | Dental care for most medically compromised patients can be accomplished if dentists understand the patients' specific medical conditions and use standard conservative behavioral or physical modifications to prevent complications from occurring. However, in patients who have certain types of neurological conditions, spe... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analgesics, Opioid', 'Anesthesia, Dental', 'Anti-Anxiety Agents', 'Benzodiazepines', 'Brain Diseases', 'Conscious Sedation', 'Cooperative Behavior', 'Dental Care for Disabled', 'Dental Restoration, Permanent', 'Dental Scaling', 'Humans', 'Hypnotics and Sedatives', 'Injections, In... | 11,833,433 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['E03.155.141', 'E06.045'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['D03.633.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Rapid determination of â-lactam antimicrobial resistance in bacteria by a liquid chromatography-mass spectrometry-based method. | Conventional antimicrobial susceptibility tests (ASTs) are very time consuming and insufficiently precise to promptly select a proper antimicrobial treatment. This difficulty disrupts the management of infections and exacerbates the development of antimicrobial resistance. Generally, antimicrobial resistance involves t... | ['Animals', 'Chromatography, High Pressure Liquid', 'Escherichia coli', 'Feces', 'Hydrolysis', 'Limit of Detection', 'Microbial Sensitivity Tests', 'Salmonella typhimurium', 'Staphylococcus aureus', 'Tandem Mass Spectrometry', 'beta-Lactam Resistance', 'beta-Lactamases', 'beta-Lactams'] | 27,744,479 | [['B01.050'], ['E05.196.181.400.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['A12.459'], ['G02.380'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. | Recent studies showed that small interfering RNAs (siRNAs) and Piwi-interacting RNA (piRNA) in mammalian germ cells play important roles in retrotransposon silencing and gametogenesis. However, subsequent contribution of those small RNAs to early mammalian development remains poorly understood. We investigated the expr... | ['Animals', 'Blastocyst', 'Blastocyst Inner Cell Mass', 'Cells, Cultured', 'DEAD-box RNA Helicases', 'Embryonic Development', 'Endoribonucleases', 'Female', 'Mice', 'Mice, Inbred ICR', 'MicroRNAs', 'Oocytes', 'RNA Interference', 'RNA, Small Interfering', 'Retroelements', 'Ribonuclease III'] | 20,385,573 | [['B01.050'], ['A16.254.500'], ['A16.254.500.533'], ['A11.251'], ['D08.811.913.696.445.735.720.249'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Denitrification in Rhizobium. | Thirty-three strains of Rhizobium were examined for their reduction of nitrate under anoxic conditions. Three patterns of dissimilatory nitrate reduction were observed: (1) reduction to N2O and N2 (denitrification), (2) reduction to and subsequent accumulation of NO2- (nitrate respiration), (3) no reduction. Strains of... | ['Anaerobiosis', 'Nitrate Reductases', 'Nitrates', 'Nitrite Reductases', 'Nitrites', 'Nitrous Oxide', 'Oxidation-Reduction', 'Rhizobium', 'Species Specificity'] | 667,742 | [['G02.111.062', 'G03.078'], ['D08.811.682.655.500'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D08.811.682.655.750'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['D01.362.635.625', 'D01.625.550.550', 'D01.650.550.587.650'], ['G02.700', 'G03.295.531'], ['B03.440.400.425.700.800', 'B03.585.900... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450. | In this study, we developed a new liquid chromatography-mass spectrometry (LC-MS) method for analysis of the protoberberine alkaloid palmatine and its metabolites with separation performed on a cyanopropyl-modified stationary phase. Palmatine (10 ìM) was metabolized using suspensions of human hepatocytes and human reco... | ['Adolescent', 'Adult', 'Berberine Alkaloids', 'Biotransformation', 'Cytochrome P-450 Enzyme System', 'Female', 'Hepatocytes', 'Humans', 'Male', 'Middle Aged', 'Recombinant Proteins', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry'] | 25,285,405 | [['M01.060.057'], ['M01.060.116'], ['D03.132.098.057', 'D03.633.400.168'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.828'], ['E05.196.566.600'], ['E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Screening for prostate cancer: role of PSA in 2006]. | PSA is the best tool for prostate cancer diagnosis. The wide use of PSA with time leads to localized tumour detection with better prognostic factors. The role of PSA for screening is debatable with a doubt on the traditional cut-off of 4 ng/ml. Lowering PSA levels leads to a higher detection rate but also increases the... | ['Biomarkers, Tumor', 'Humans', 'Male', 'Predictive Value of Tests', 'Prostate-Specific Antigen', 'Prostatic Neoplasms'] | 17,091,883 | [['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.249.500', 'D23.050.285.625', 'D23.101.140.625'], ['C04.588.945.440.770', 'C12.294.260.750'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Sensitivity of creatine kinase and creatine kinase MB in myocardial infarction. Evaluation of a new optimized standard method (author's transl)]. | In 70 patients with confirmed transmural myocardial infarction the sensitivity of creatine kinase and creatine kinase MB at different times after admission was investigated by 364 measurements. Beside the number of correctly positive results the optimized standard method hitherto used was compared with the new optimize... | ['Acetylcysteine', 'Creatine Kinase', 'Humans', 'Isoenzymes', 'Myocardial Infarction'] | 431,469 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy? | A wide range of studies both in humans and animal models point GALNT2 as a shaper of serum HDL-C and TG levels. Available data in humans indicate that, while under conditions of extreme GALNT2 loss-of-function HDL-C is the main target, a fine-tuning of GALNT2 changes is mostly associated with TG levels. Understanding w... | ['Animals', 'Biomarkers', 'Cholesterol, HDL', 'Dyslipidemias', 'Gene Expression Regulation, Enzymologic', 'Genetic Pleiotropy', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'N-Acetylgalactosaminyltransferases', 'Triglycerides'] | 28,153,384 | [['B01.050'], ['D23.101'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['C18.452.584.500'], ['G05.308.320'], ['G05.420.556', 'G05.695.550'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.400.100.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PhiC31/PiggyBac modified stromal stem cells: effect of interferon ã and/or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on murine melanoma. | BACKGROUND: TRAIL and IFNã are promising anti-cancer cytokines and it has been shown that IFNã may sensitize cancer cells to TRAIL. Adipose derived mesenchymal stem cells (ADSCs) are attractive vehicles for delivering anti-cancer agents. In this study, we evaluated the therapeutic potential of PhiC31 (öC31) recombinase... | ['Animals', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Cell Line, Tumor', 'Humans', 'Interferon-gamma', 'Interleukin-2', 'Lung Neoplasms', 'MCF-7 Cells', 'Male', 'Melanoma', 'Mice', 'Mice, Inbred C57BL', 'Nerve Tissue Proteins', 'Recombinases', 'Signal Transduction', 'Stem Cells', 'Stromal Cells', 'T-Lymphocytes, R... | 25,428,727 | [['B01.050'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fifth ?land Island conference on von Willebrand disease. | The fifth ?land Island meeting on von Willebrand disease (VWD) was held on the ?land Islands, Finland, from 22 to 24 September 2016-90 years after the first case of VWD was diagnosed in a patient from the ?land Islands in 1926. This meeting brought together experts in the field of VWD to share knowledge and expertise o... | ['Humans', 'von Willebrand Diseases'] | 29,687,935 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.100.100.900', 'C15.378.100.141.900', 'C15.378.140.900', 'C15.378.463.920', 'C16.320.099.920']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A possible zymogen self-destruct mechanism preventing pancreatic autodigestion. | Incubation at 37 degrees C of human cationic trypsinogen purified by PAGE electrophoresis, results in development of proteolytic activity (enzyme Y) capable of rapidly degrading cationic and anionic trypsinogens to inert products. Enzyme Y appears to be a serine protease with a molecular weight of about 20,000 daltons ... | ['Autolysis', 'Enzyme Precursors', 'Humans', 'Isoflurophate', 'Molecular Weight', 'Pancreas', 'Pancreatic Juice', 'Serine Endopeptidases', 'Trypsinogen'] | 3,162,506 | [['C23.550.260.224.617.236'], ['D08.622', 'D12.776.811.243'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.705.429.750.249'], ['G02.494'], ['A03.734'], ['A12.200.567'], ['D08.811.277.656.300.760', 'D08.811.277.656.959.350'], ['D08.622.885', 'D12.776.811.243.885']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of a novel double-mutant dihydrofolate reductase-cytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside. | A novel fusion gene consisting of the open reading frame of a double-mutant (Phe22-Ser31) dihydrofolate reductase (dmDHFR) cDNA fused to the open reading frame of cytidine deaminase (CD) was constructed and characterized for the purpose of conferring simultaneous resistance to methotrexate (MTX) and cytosine arabinosid... | ['3T3 Cells', 'Animals', 'Artificial Gene Fusion', 'Base Sequence', 'Bone Marrow', 'Cell Survival', 'Cytarabine', 'Cytidine Deaminase', 'DNA Primers', 'Drug Resistance', 'Genetic Vectors', 'Kinetics', 'Methotrexate', 'Mice', 'Polymerase Chain Reaction', 'Retroviridae', 'Tetrahydrofolate Dehydrogenase'] | 10,543,614 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['E05.393.220.250'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A15.382.216'], ['G04.346'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D08.811.277.151.486.250'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor. | RPR127963 demonstrates an excellent pharmacokinetic profile in several species and was found to be efficacious in the prevention of restenosis in a Yucatan mini-pig model upon oral administration of 1-5 mg/kg. The in vitro selectivity profile and SAR of the highly optimized PDGF-R tyrosine kinase inhibitor are highligh... | ['Administration, Oral', 'Animals', 'Biological Availability', 'Cell Division', 'Chemotaxis', 'Collagen', 'Cytochrome P-450 Enzyme System', 'Enzyme Inhibitors', 'Inhibitory Concentration 50', 'Protein-Tyrosine Kinases', 'Quinoxalines', 'Rats', 'Receptors, Platelet-Derived Growth Factor', 'Structure-Activity Relationshi... | 12,941,342 | [['E02.319.267.100'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D08.244.453'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid and sensitive detection of retrovirus entry by using a novel luciferase-based content-mixing assay. | We describe a novel assay that permits measurement of entry of murine leukemia virus and pseudotypes with greater sensitivity and more rapidly than previously possible. To achieve this, we encapsulated a sensitive reporter enzyme, luciferase, directly into fully infectious, intact viral particles. The enzyme is specifi... | ['Cell Line', 'Edetic Acid', 'Humans', 'Hydrogen-Ion Concentration', 'Leukemia Virus, Murine', 'Luciferases', 'Membrane Fusion', 'Receptors, Virus', 'Sensitivity and Specificity', 'Virion'] | 15,113,894 | [['A11.251.210'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['B04.613.807.375.525', 'B04.820.650.375.525'], ['D08.811.682.517', 'D12.776.532.510'], ['G04.575'], ['D12.776.543.750.830'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Candida albicans brain abscesses in an injection drug user patient: a case report. | BACKGROUND: Fungal brain abscess is an uncommon disease, mostly associated with immunocompromised states and poorly controlled diabetes. Its incidence, however, is rising as a result of the increasing use of immunosuppressive agents, corticosteroids and broad-spectrum antimicrobial therapy. Candida species have emerged... | ['Antifungal Agents', 'Brain Abscess', 'Candida albicans', 'Drug Users', 'Follow-Up Studies', 'Hospitalization', 'Humans', 'Injections', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Substance Abuse, Intravenous', 'Tomography, X-Ray Computed'] | 25,421,883 | [['D27.505.954.122.136'], ['C01.207.090', 'C01.830.025.160', 'C10.228.140.116', 'C10.228.228.090'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['M01.169'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E02.760.400', 'N02.421.585.400'], ['B01... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
AIDS-defining opportunistic illnesses in the HAART era in New York City. | Despite widespread availability of HAART, opportunistic illnesses (OIs) still occur and result in an increased risk of mortality among persons with AIDS. We estimated the incidence of OIs among all new adult AIDS cases in New York City in 2000 overall and in demographic and clinical subgroups and identified factors ass... | ['AIDS-Related Opportunistic Infections', 'Adolescent', 'Adult', 'Antiretroviral Therapy, Highly Active', 'Early Diagnosis', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'New York City'] | 17,364,409 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.057'], ['M01.060.116'], ['E02.319.310.075'], ['E01.390'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'],... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Effect of cutting, phosphorus and potassium fertilization on guar plant (Cyamoposis tetragonoloba) in newly reclaimed soil in Egypt. | A two year experiment was carried out in newly reclaimed soils (sandy soils) to investigate the effect of cutting and phosphorus and potassium fertilization on the growth, yield, seed mucilage content and seed protein content of guar plant. The results revealed that different cutting treatments significantly decreased ... | ['Egypt', 'Fabaceae', 'Fertilizers', 'Phosphorus', 'Plant Proteins', 'Plants, Medicinal', 'Seeds', 'Soil', 'Sulfates'] | 8,295,868 | [['Z01.058.266.317'], ['B01.650.940.800.575.912.250.401'], ['D27.720.031.400'], ['D01.268.666'], ['D12.776.765'], ['B01.650.560'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D01.248.497.158.845', 'D01.875.800.800.850']] | ['Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Antenatal noninvasive treatment of patients at risk for alloimmune thrombocytopenia without a history of intracranial hemorrhage. | OBJECTIVE: The purpose of this study was to evaluate noninvasive management of alloimmune thrombocytopenia that included only the blind administration of immunoglobulin.STUDY DESIGN: Seventeen women with 30 pregnancies that were at risk of neonatal alloimmune thrombocytopenia were included. Except for 6 cases, in which... | ['Adult', 'Antigens, Human Platelet', 'Blood Specimen Collection', 'Female', 'Fetal Diseases', 'Humans', 'Immunoglobulins, Intravenous', 'Infant, Newborn', 'Intracranial Hemorrhages', 'Platelet Count', 'Pregnancy', 'Thrombocytopenia'] | 17,000,248 | [['M01.060.116'], ['D23.050.705.115'], ['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['C13.703.277', 'C16.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393.536', 'D12.776.124.486.485.114.632', 'D12.776.124.790.651.114.632', 'D12.776.377.715.548.114.632'], ['M01.060.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma. | OBJECTIVES: Accurate diagnosis of invasion depth is important for reliable treatment of esophageal squamous cell carcinoma (ESCC), but it is limited to the muscularis mucosae to slight submucosal invasion (MM/SM1). The diagnostic accuracy of invasion depth is unsatisfactory and remains to be improved. We aimed to inves... | ['Aged', 'Aged, 80 and over', 'Color', 'Endoscopic Mucosal Resection', 'Endoscopy, Gastrointestinal', 'Esophageal Mucosa', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Esophagectomy', 'Female', 'Humans', 'Lymph Node Excision', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Retrospective Studies'] | 31,220,372 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G01.590.540.199'], ['E01.370.372.250.250.250', 'E01.370.388.250.250.250.230', 'E04.210.240.250.230', 'E04.502.250.250.250.230'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['A03.556.875.500.180', 'A10.615.550.146'], ['C0... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development and characterisation of chondroitin sulfate- and hyaluronic acid-incorporated sorbitan ester nanoparticles as gene delivery systems. | Glycosaminoglycans (GAGs) are natural polymers that are broadly used in gene delivery systems to increase stability as well as decrease toxicity and nonspecific interactions, thereby increasing transfection efficiency. In this work, we propose sorbitan ester-based lipid nanoparticles (SENS) functionalised with the GAGs... | ['A549 Cells', 'Animals', 'Cell Survival', 'Chondroitin Sulfates', 'Gene Transfer Techniques', 'Green Fluorescent Proteins', 'Hexoses', 'Humans', 'Hyaluronic Acid', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Nanoparticles', 'Particle Size'] | 29,355,685 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['B01.050'], ['G04.346'], ['D09.698.373.200.300'], ['E05.393.350'], ['D12.776.532.265'], ['D09.947.875.359'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.373.475'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338',... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Prognostic factors in renal cell carcinoma: analysis of 227 patients treated at the Brazilian National Cancer Institute. | PURPOSE: We evaluated the role of several prognostic factors in predicting death and/or progressive disease in patients with renal cell carcinoma.MATERIALS AND METHODS: Between 2004 and 2010, 227 consecutive patients with renal cell carcinoma underwent radical nephrectomy at our Institute. All histological specimens we... | ['Academies and Institutes', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brazil', 'Carcinoma, Renal Cell', 'Child', 'Child, Preschool', 'Disease-Free Survival', 'Female', 'Humans', 'Kidney Neoplasms', 'Lymph Nodes', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Nephrectomy', 'Prognosis',... | 22,555,027 | [['N03.540.052'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.176'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['M01.060.406'], ['M01.060.406.448'], ['E01.7... | ['Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Viscerosomatic convergence onto feline spinal neurons from esophagus, heart and somatic fields: effects of inflammation. | One objective of this study was to examine a mechanism for the inability of patients to distinguish esophageal pain from cardiac pain. Patients with esophageal disease and angina pectoris often perceive pain as originating from the same somatic fields. Another objective was to compare the effect of esophageal distensio... | ['Afferent Pathways', 'Animals', 'Cats', 'Electric Stimulation', 'Esophagus', 'Female', 'Heart', 'Inflammation', 'Male', 'Neurons', 'Pain', 'Spinal Cord'] | 1,408,304 | [['A08.612.220'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['A03.556.875.500'], ['A07.541'], ['C23.550.470'], ['A08.675', 'A11.671'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A08.186.854']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The impact of conditional cash transfers on nutrition outcomes: Experimental evidence from Mexico. | In this paper, we study the effect of Progresa, a conditional cash transfer program in Mexico, on the micronutrient and macronutrient consumption levels of program participants. Overall, we find that Progresa has a complicated effect on nutrition outcomes. We find that treatment households increase their vitamin consum... | ['Adolescent', 'Child', 'Diet', 'Female', 'Humans', 'Male', 'Mexico', 'Micronutrients', 'Motivation', 'Nutritional Status', 'Overweight', 'Poverty', 'Public Assistance'] | 30,901,620 | [['M01.060.057'], ['M01.060.406'], ['G07.203.650.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.589'], ['D27.505.696.494', 'G07.203.300.681.500', 'J02.500.681.500'], ['F01.658', 'F01.752.543.500.750'], ['G07.203.650.650', 'N01.224.425.525'], ['C23.888.144.699', 'E01.370.600.115.100.160.120.699', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Edu... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Nematode-induced eosinophilic intestinal granuloma. Case report]. | The eosinophilic granuloma of the gastrointestinal tract was in recent years observed more frequently in infections with larvae of the herring-roundworm Anisakis. The associated symptoms are similar to those of acute appendicitis. Proof of a worm within the granuloma is usually easy, where as the classification to indi... | ['Adult', 'Animals', 'Ascaridoidea', 'Cecal Diseases', 'Cecum', 'Eosinophilic Granuloma', 'Female', 'Humans', 'Intestinal Diseases, Parasitic', 'Intestinal Mucosa', 'Intestinal Perforation', 'Larva', 'Nematode Infections'] | 3,433,852 | [['M01.060.116'], ['B01.050'], ['B01.050.500.500.294.400.500.100'], ['C06.405.469.110'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['C05.116.391', 'C08.381.483.375.500', 'C15.378.553.231.348', 'C15.604.250.400.360', 'C23.550.382.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.432', 'C06.405.469.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The proteomic complexity and rise of the primordial ancestor of diversified life. | BACKGROUND: The last universal common ancestor represents the primordial cellular organism from which diversified life was derived. This urancestor accumulated genetic information before the rise of organismal lineages and is considered to be either a simple 'progenote' organism with a rudimentary translational apparat... | ['Archaea', 'Bacteria', 'Eukaryota', 'Evolution, Molecular', 'Genome', 'Phylogeny', 'Protein Conformation', 'Protein Structure, Tertiary', 'Proteome'] | 21,612,591 | [['B02'], ['B03'], ['B01'], ['G05.045.250', 'G16.075.250'], ['G05.360.340'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G02.111.570.820.709'], ['G02.111.570.820.709.610'], ['D12.776.817']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pastoral care and counseling with the "un-homeless homeless": understanding cultures of homelessness. | This article presents a subset of findings from a larger study exploring the lived experiences of 16 former residents of a 90-day emergency family shelter program in Los Angeles County. Interpretative phenomenological analysis serves as a qualitative method for understanding the cultural uniqueness of the "un-homeless ... | ['Adult', 'Attitude to Health', 'Counseling', 'Cultural Competency', 'Female', 'Homeless Persons', 'Humans', 'Los Angeles', 'Male', 'Middle Aged', 'Pastoral Care', 'Patient Acceptance of Health Care', 'Professional-Patient Relations', 'Spirituality', 'Young Adult'] | 25,241,491 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['I01.880.853.100.364'], ['M01.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.580.200.450', 'Z01.107.567.875.760.200.450', 'Z01.433.565'], ['M01.060.116.630'], ['F02.784.176... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Materials and shapes: the compromise]. | The development and fabrication of a prosthesis of the knee which for many years will fulfil the functions of a normal knee result from a very complex compromise between materials and shapes. It is essential to select materials and shapes whose characteristics are complying with the specifications laid down for this pa... | ['Biocompatible Materials', 'Humans', 'Knee Prosthesis', 'Prosthesis Design'] | 1,853,106 | [['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400.410'], ['E05.320.550', 'E07.695.680']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Impact of social changes on female mentally disordered offenders from 1980 to 1994 in Japan. | Social change, particularly in mental health policy, may affect the distribution of crime and the legal process. This article presents trends in female crimes during a 15-year period (1980 to 1994) and examines the characteristics of the 1980 and the 1994 group of female mentally disordered offenders (MDOs) in Japan. D... | ['Adult', 'Aged', 'Community Mental Health Services', 'Crime', 'Female', 'Humans', 'Japan', 'Mental Disorders', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Retrospective Studies', 'Social Change'] | 9,323,656 | [['M01.060.116'], ['M01.060.116.100'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['I01.198.240', 'I01.880.735.191'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['F03'], ['M01.060.116.630'], ['F04.711.513.653'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Uhrf2 is important for DNA damage response in vascular smooth muscle cells. | Emerging evidence shows that Uhrf1 plays an important role in DNA damage response for maintaining genomic stability. Interestingly, Uhrf1 has a paralog Uhrf2 in mammals. Uhrf1 and Uhrf2 share similar domain architectures. However, the role of Uhrf2 in DNA damage response has not been studied yet. During the analysis of... | ['Animals', 'Cell Line', 'DNA Damage', 'DNA Repair', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Gene Knockdown Techniques', 'Lasers', 'Mice', 'Muscle, Smooth, Vascular', 'Myocytes, Smooth Muscle', 'Ubiquitin-Protein Ligases'] | 24,134,842 | [['B01.050'], ['A11.251.210'], ['G05.200'], ['G02.111.222', 'G05.219'], ['E05.393.332'], ['G05.308'], ['E05.393.335.500'], ['E07.632.490', 'E07.710.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['A11.620.520'], ['D08.811.464.938.750']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cloning and characterization of 5'-untranslated region of porcine beta casein gene (CSN2). | beta-Casein (CSN2) is a major milk protein in most mammals. The CSN2 gene is generally induced by lactogenic hormones bound to its promoter. The expression of this gene can be enhanced by signal transducers and activators of transcription (STAT) and glucocorticoid receptor (GR). Here, we analyzed the promoter and intro... | ["5' Untranslated Regions", 'Animals', 'Caseins', 'Cell Line', 'Cloning, Molecular', 'Electrophoretic Mobility Shift Assay', 'Enzyme Inhibitors', 'Female', 'Gene Expression Regulation', 'Introns', 'Mice', 'Mutagenesis, Site-Directed', 'Promoter Regions, Genetic', 'RNA, Messenger', 'STAT5 Transcription Factor', 'Swine',... | 18,583,090 | [['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['A11.251.210'], ['E05.393.220'], ['E05.196.401.500'], ['D27.505.519.389'], ['G05.308'], ['G05.360.340.024.220.400', 'G05.360.340.024.34... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new fixed cryosection technique for the simultaneous immunocytochemical demonstration of T6 and S100 antigens. | A formalin-calcium fixation method of preparing cryosections is described, which allows demonstration of Langerhans' cells by S100 antigen staining on frozen sections. The number of Langerhans' cells given by T6 antigen staining is also higher in formalin-calcium fixed frozen sections than acetone fixed frozen sections... | ['Adult', 'Antigens, Differentiation, T-Lymphocyte', 'Antigens, Surface', 'Cervix Uteri', 'Female', 'Frozen Sections', 'Histocytochemistry', 'Humans', 'Immunochemistry', 'Langerhans Cells', 'Microtomy', 'Middle Aged', 'S100 Proteins'] | 3,108,204 | [['M01.060.116'], ['D23.050.301.264.894', 'D23.101.100.894'], ['D23.050.301'], ['A05.360.319.679.256'], ['E01.370.225.500.620.530.160.260', 'E01.370.225.750.600.530.160.260', 'E05.200.500.620.530.160.260', 'E05.200.750.600.530.160.260'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A rapid sample preparation method for PCR detection of food pathogens based on buoyant density centrifugation. | The use of buoyant density centrifugation (BDC) to prepare samples for PCR analysis of food pathogens is described. Blue cheese and milk homogenates were inoculated with Shigella flexneri and layered on top of Percoll media. After BDC, the food homogenates remained in the upper part of the centrifuge tube, separated fr... | ['Animals', 'Bacteriological Techniques', 'Centrifugation, Density Gradient', 'Cheese', 'Colony Count, Microbial', 'DNA, Bacterial', 'Evaluation Studies as Topic', 'Food Microbiology', 'Milk', 'Polymerase Chain Reaction', 'Shigella flexneri', 'Yersinia enterocolitica'] | 9,134,780 | [['B01.050'], ['E01.370.225.875.150', 'E05.200.875.150'], ['E05.181.724.336', 'E05.196.941.336'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D13.444.308.212'], ['E05.337', 'N05.715.360.335'], ['H01.158.273.540.274.332', 'J0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Fast screening of aflatoxins in dairy cattle feeds with CE-LIF method combined with preconcentration technique of vortex assisted low density solvent-microextraction. | Aflatoxin contamination in agricultural products poses a great threat to humans and livestock. The aim of this study was to establish a simple, rapid, highly sensitive, and inexpensive method for the simultaneous detection of aflatoxin B1 , B2 , G1 , and G2 in agricultural products. We used a vortex assisted low densit... | ['Aflatoxins', 'Animal Feed', 'Chromatography, Micellar Electrokinetic Capillary', 'Food Contamination', 'Limit of Detection', 'Linear Models', 'Liquid Phase Microextraction', 'Reproducibility of Results'] | 30,467,879 | [['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['G07.203.300.300.100', 'J02.500.300.100'], ['E05.196.181.500'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.318.740.500.500', 'E05.318.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
An orphaned mammalian beta-globin gene of ancient evolutionary origin. | Mammals possess multiple, closely linked beta-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characteri... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'Evolution, Molecular', 'Gene Duplication', 'Globins', 'Humans', 'Mammals', 'Marsupialia', 'Molecular Sequence Data', 'Phylogeny', 'Polymerase Chain Reaction', 'Sequence Alignment'] | 11,158,601 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['G05.045.250', 'G16.075.250'], ['G05.365.590.320', 'G05.558.320'], ['D12.776.422.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649'], ['B01.050.150.900.649.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Stretching exercises enhance vascular endothelial function and improve peripheral circulation in patients with acute myocardial infarction. | The purpose of this study was to clarify the acute effects of a single session of stretching exercises on vascular endothelial function and peripheral circulation in patients with acute myocardial infarction. This study evaluated 32 patients (mean age, 66 ± 9 years) who received phase I cardiac rehabilitation after acu... | ['Aged', 'Arterioles', 'Blood Circulation', 'Endothelium, Vascular', 'Extremities', 'Female', 'Humans', 'Male', 'Middle Aged', 'Muscle Stretching Exercises', 'Myocardial Infarction', 'Nitric Oxide', 'Vasodilation'] | 23,676,363 | [['M01.060.116.100'], ['A07.015.114.060', 'A07.015.461.080'], ['G09.330.100'], ['A07.015.700.500', 'A10.272.491.355'], ['A01.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.169.063.500.387.750', 'E02.779.483.750', 'E02.831.535.483.750', 'G11.427.410.698.277.249', 'I03.350.249'], [... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
A new stereophonic stethoscope. | A new stereophonic stethoscope is presented. It is characterized by a single chest piece construction housing paired open-bell type sound accumulating chambers and paired diaphragm type sound accumulating chambers. A pair of separate ear tubes connected to each of the paired sound chambers establish two cross talk-free... | ['Equipment Design', 'Evaluation Studies as Topic', 'Heart Auscultation', 'Humans'] | 2,084,280 | [['E05.320'], ['E05.337', 'N05.715.360.335'], ['E01.370.370.380.400', 'E01.370.600.060.400'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. | OBJECTIVE: Juvenile idiopathic arthritis (JIA) is characterized by chronic arthritis and an autoimmune etiology. In several autoimmune diseases, including rheumatoid arthritis (RA), an association with the 4q27 locus has been reported. We undertook this study to investigate the possible role of the 4q27 locus in JIA.ME... | ['Adolescent', 'Adult', 'Arthritis, Juvenile', 'Arthritis, Psoriatic', 'Arthritis, Rheumatoid', 'Autoimmunity', 'Case-Control Studies', 'Celiac Disease', 'Chromosomes, Human, Pair 4', 'Diabetes Mellitus, Type 1', 'European Continental Ancestry Group', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Humans'] | 19,248,117 | [['M01.060.057'], ['M01.060.116'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['G12.450.192'], ['E05.318.372.500.500', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sex-Specific Prediction Models for Sleep Apnea From the Hispanic Community Health Study/Study of Latinos. | OBJECTIVE: We developed and validated the first-ever sleep apnea (SA) risk calculator in a large population-based cohort of Hispanic/Latino subjects.METHODS: Cross-sectional data on adults from the Hispanic Community Health Study/Study of Latinos (2008-2011) were analyzed. Subjective and objective sleep measurements we... | ['Adult', 'Clinical Decision-Making', 'Cohort Studies', 'Cross-Sectional Studies', 'Female', 'Hispanic Americans', 'Humans', 'Male', 'Models, Statistical', 'Polysomnography', 'Prevalence', 'Risk Factors', 'Sex Factors', 'Sleep Apnea Syndromes', 'United States'] | 26,836,933 | [['M01.060.116'], ['E01.055'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Inhibition of Lactobacillus biofilm growth in fuel ethanol fermentations by Bacillus. | Commercial fuel ethanol fermentations suffer from microbial contaminants, particularly species of Lactobacillus that may persist as antibiotic-resistant biofilms. In this study, culture supernatants from 54 strains of Bacillus known to produce lipopeptides were tested for inhibition of biofilm formation by Lactobacillu... | ['Bacillus', 'Biofilms', 'Ethanol', 'Fermentation', 'Lactobacillus', 'Lipopeptides', 'Saccharomyces cerevisiae'] | 30,336,397 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['A20.593', 'G06.120'], ['D02.033.375'], ['G02.111.158.249', 'G03.191.249'], ['B03.353.750.450.475', 'B03.510.460.400.410.475.475', 'B03.510.550.450.475'], ['D10.477', 'D12.644.365'], ['B01.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Greater progression of coronary artery calcification is associated with clinically relevant cognitive impairment in type 1 diabetes. | BACKGROUND AND AIMS: We assessed the predictive role of coronary artery calcification (CAC) in clinically relevant cognitive impairment in 148 middle-aged individuals with childhood-onset type 1 diabetes (T1D) from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.METHODS: Baseline CAC was measured in 1... | ['Adolescent', 'Adult', 'Ankle Brachial Index', 'Calcinosis', 'Child', 'Cognitive Dysfunction', 'Coronary Artery Disease', 'Diabetes Complications', 'Diabetes Mellitus, Type 1', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Predictive Value of Tests'... | 30,471,556 | [['M01.060.057'], ['M01.060.116'], ['E01.370.370.140.049'], ['C18.452.174.130'], ['M01.060.406'], ['F03.615.250.700'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C19.246.099'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Per- and polyfluorinated compounds in house dust and indoor air from northern Norway - a pilot study. | Polyfluorinated compounds (PFCs) are an extremely versatile class of compounds and are used in a variety of consumer applications and products. Recent studies have suggested that PFCs in indoor air and dust could act as sources of human exposure and outdoor air contamination. This study presents method development and ... | ['Air Pollution, Indoor', 'Alkanesulfonic Acids', 'Caprylates', 'Dust', 'Environmental Monitoring', 'Fluorocarbons', 'Gas Chromatography-Mass Spectrometry', 'Norway', 'Pilot Projects', 'Polyurethanes'] | 21,632,089 | [['N06.850.460.100.080'], ['D02.455.326.146.100', 'D02.886.645.600.055'], ['D02.241.081.222', 'D10.251.122'], ['D20.633.222'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D02.455.526.510.435'], ['E05.196.181.349.500', 'E05.196.566.500'], ['Z01.542.816.374'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', '... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study. | OBJECTIVE: To investigate the association between cardiac function and the risk of stroke and dementia in elderly free of clinical cardiac disease. Additionally, we investigated the relation between cardiac function and MRI markers of subclinical cerebrovascular disease.METHODS: This study was conducted within the popu... | ['Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Cohort Studies', 'Dementia', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Netherlands', 'Population Surveillance', 'Prospective Studies', 'Risk Factors', 'Stroke'] | 25,632,093 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C10.228.140.380', 'F03.615.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Encephalopathy due to tubercular otitis media. | Middle ear infection due to Mycobacterium tuberculosis has been reduced from 3-5% to 0.05-0.9% in the last century due to advent of effective anti-tuberculosis therapy. On the other side, this decrease in frequency of tuberculous otitis media along with indistinguishable signs and symptoms of frequently occurring non-t... | ['Adult', 'Brain Diseases', 'Fatal Outcome', 'Granulation Tissue', 'Humans', 'Male', 'Otitis Media', 'Radiography', 'Temporal Bone', 'Tuberculosis'] | 22,838,209 | [['M01.060.116'], ['C10.228.140'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['A10.165.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.705.663'], ['E01.370.350.700'], ['A02.835.232.781.885'], ['C01.150.252.410.040.552.846']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol. | Assays for two distinct phosphatidate phosphohydrolase activities were established based upon a differential inhibition by N-ethylmaleimide (NEM). The activity that is insensitive to this reagent in rat liver is predominantly in the plasma membrane fraction, whereas the NEM-sensitive activity is in the cytosolic and mi... | ['Animals', 'Calcium', 'Cell Membrane', 'Cells, Cultured', 'Chlorpromazine', 'Endoplasmic Reticulum', 'Ethylmaleimide', 'Hot Temperature', 'Liver', 'Magnesium', 'Male', 'Octoxynol', 'Phosphatidate Phosphatase', 'Polyethylene Glycols', 'Propranolol', 'Rats', 'Rats, Inbred Strains', 'Spermine', 'Sphingosine'] | 1,993,672 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.149'], ['A11.251'], ['D02.886.369.198', 'D03.633.300.783.198'], ['A11.284.430.214.190.875.248'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Asymmetric distribution of biotin labeling on the purple membrane. | This work examined the biotin modification of bacteriorhodopsin (BR) in the purple membrane (PM). The results of flash kinetic absorption measurements showed that photocycle was maintained in biotinylated BR. Biotinylated BR also maintained its photoelectric activity, as indicated by the photoelectric response of the b... | ['Bacteriorhodopsins', 'Biotin', 'Cytoplasm', 'Fluorescamine', 'Halobacterium salinarum', 'Kinetics', 'Microscopy, Atomic Force', 'Photochemistry', 'Purple Membrane', 'Streptavidin', 'Surface Properties'] | 18,619,849 | [['D12.776.090.200', 'D12.776.157.530.450.250.875.249', 'D12.776.543.585.450.250.875.249', 'D12.776.752.812.249'], ['D03.383.129.308.080', 'D08.211.096'], ['A11.284.430.214'], ['D02.455.426.779.345', 'D03.633.100.127.218', 'D04.711.345'], ['B02.200.400.400.410.450'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.66... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Functionalized Graphene Oxide with Hepatocyte Targeting as Anti-Tumor Drug and Gene Intracellular Transporters. | In order to realize the hepatocyte-specific targeted delivery of anti-tumor drug and gene, lactosylated chitosan oligosaccharide (LCO) functionalized graphene oxides (GO-LCO) containing quaternary ammonium groups (GO-LCO+) were prepared. The formation and composition of GO-LCO+ were confirmed by FTIR, AFM, TGA and zeta... | ['Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Survival', 'Chitosan', 'DNA', 'Doxorubicin', 'Drug Carriers', 'Drug Liberation', 'Fluorescein', 'Graphite', 'Hepatocytes', 'Humans', 'Oligosaccharides', 'Oxides'] | 26,413,620 | [['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D13.444.308'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D26.255.260', 'E02.319.300.380'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D02.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Repeatability of corneal elevation maps in keratoconus patients using the tomography matching method. | To assess repeatability of corneal tomography in successive measurements by Pentacam in keratoconus (KC) and normal eyes based on the Iterative Closest Point (ICP) algorithm. The study involved 143 keratoconic and 143 matched normal eyes. ICP algorithm was used to estimate six single and combined misalignment (CM) para... | ['Cornea', 'Corneal Topography', 'Female', 'Humans', 'Keratoconus', 'Male', 'Reproducibility of Results', 'Tomography', 'Young Adult'] | 29,234,085 | [['A09.371.060.217'], ['E01.370.380.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.627'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E01.370.350.825'], ['M01.060.116.815']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Germline and mosaic mutations of FLN1 in men with periventricular heterotopia. | OBJECTIVE: To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men.BACKGROUND: X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women.METHO... | ['Abnormalities, Multiple', 'Brain Diseases', 'Cell Movement', 'Cerebral Ventricles', 'Child, Preschool', 'Choristoma', 'Chromosomes, Human, X', 'Cisterna Magna', 'Contractile Proteins', 'DNA Mutational Analysis', 'Dosage Compensation, Genetic', 'Female', 'Filamins', 'Genes, Lethal', 'Genetic Diseases, X-Linked', 'Germ... | 15,249,610 | [['C16.131.077'], ['C10.228.140'], ['G04.198', 'G07.568.500.180'], ['A08.186.211.140'], ['M01.060.406.448'], ['C23.300.250'], ['A11.284.187.520.300.325.680', 'A11.284.187.865.982.500', 'G05.360.162.520.300.325.680', 'G05.360.162.865.982.500'], ['A08.186.566.166.686.351'], ['D12.776.210'], ['E05.393.760.700.300'], ['G05... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood. | Chronic lymphocytic leukemia (CLL) is a progressive malignancy of mature B-cells that involves the peripheral blood (PB), lymph nodes (LNs) and bone marrow (BM). Although the majority of CLL cells are in a resting state, small populations of proliferating cells exist; however, the anatomical site of active cell prolife... | ['Aged', 'Apoptosis', 'B-Lymphocytes', 'Bone Marrow', 'Cell Proliferation', 'Female', 'Flow Cytometry', 'Humans', 'Immunophenotyping', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukocytes, Mononuclear', 'Lymph Nodes', 'Lymphocyte Activation', 'Male', 'Middle Aged', 'Tumor Cells, Cultured'] | 28,074,063 | [['M01.060.116.100'], ['G04.146.954.035'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A15.382.216'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Translational pharmacology of an inhaled small molecule ávâ6 integrin inhibitor for idiopathic pulmonary fibrosis. | The ávâ6 integrin plays a key role in the activation of transforming growth factor-â (TGFâ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule ávâ6 RGD-mimetic, GSK3008348, and profiled it in a range of disease relevant pre-clinic... | ['Administration, Inhalation', 'Animals', 'Antigens, Neoplasm', 'Bleomycin', 'Butyrates', 'Collagen', 'Disease Models, Animal', 'Epithelial Cells', 'Humans', 'Idiopathic Pulmonary Fibrosis', 'Integrins', 'Male', 'Mice, Inbred C57BL', 'Molecular Docking Simulation', 'Naphthyridines', 'Pyrazoles', 'Pyrrolidines', 'Small ... | 32,938,936 | [['E02.319.267.050'], ['B01.050'], ['D23.050.285'], ['D09.400.420.110', 'D12.644.233.110'], ['D02.241.081.114', 'D10.251.400.143'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.765.500'], ['D12.776.543.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
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