Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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DNA sequence of a Salmonella-specific DNA fragment and the use of oligonucleotide probes for Salmonella detection. | Hybridization specificity of a 1.8-kb HindIII DNA fragment isolated from Salmonella typhimurium by a molecular cloning technique was confirmed by colony hybridization with 327 Salmonella isolates of various serotypes and 56 non-Salmonella isolates including Enterobacteriaceae closely related to Salmonella, such as Esch... | ['Base Sequence', 'DNA Probes', 'DNA, Bacterial', 'Enterobacteriaceae', 'Food Microbiology', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Salmonella', 'Salmonella typhimurium'] | 1,367,316 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.212'], ['B03.440.450.425', 'B03.660.250.150'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.24... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Better glycaemic control with BioChaperone glargine lispro co-formulation than with insulin lispro Mix25 or separate glargine and lispro administrations after a test meal in people with type 2 diabetes. | Because of its physico-chemical properties, insulin glargine is usually not mixable with rapid insulins. BioChaperone BC147 is a polyanionic amphiphilic polymer, solubilizing insulin glargine at neutral pH, and thus enabling stable glargine formulation with fast-acting insulin lispro (BioChaperone glargine lispro co-fo... | ['Adolescent', 'Adult', 'Aged', 'Blood Glucose', 'Diabetes Mellitus, Type 2', 'Drug Combinations', 'Female', 'Humans', 'Hypoglycemia', 'Hypoglycemic Agents', 'Insulin Glargine', 'Insulin Lispro', 'Male', 'Middle Aged', 'Postprandial Period', 'Young Adult'] | 30,828,929 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['D27.505.696.422'], ['D06.472.699.587.200.300.100', 'D12.644.548.586.200.300.100'], ['D06.472.699.587.200.400.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Copper effects on ion transport across lamprey erythrocyte membrane: Cl(-)/OH(-) exchange induced by cuprous ions. | We studied the effects of prelytic copper concentrations on cell volume, intracellular pH, and ion transport in lamprey erythrocytes. Ion fluxes and pH were measured by radioactive tracer technique, patch clamp, and flame photometry. Prelytic CuSO(4) concentration of 100 microM caused anion-dependent intracellular acid... | ['Animals', 'Antiporters', 'Cations', 'Chlorides', 'Copper', 'Erythrocyte Membrane', 'Hydrogen-Ion Concentration', 'Ion Transport', 'Lampreys', 'Patch-Clamp Techniques', 'Potassium', 'Proton Pumps', 'Reducing Agents', 'Sodium', 'Sulfhydryl Reagents'] | 10,486,307 | [['B01.050'], ['D12.776.157.530.450.162', 'D12.776.543.550.190', 'D12.776.543.585.450.162'], ['D01.248.497.300'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['G02.300'], ['G03.143.500'], ['B01.050.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of carotid stenting on endarterectomy practice--A single institution experience. | OBJECTIVES: The number of operations performed per surgeon is thought to determine the quality of carotid endarterectomy (CEA) surgery. The advent of carotid artery stenting (CAS) threatens to reduce the volume of CEA. This paper assesses CEA and the effects of the introduction of CAS service on outcomes.DESIGN: Retros... | ['Aged', 'Carotid Stenosis', 'Endarterectomy, Carotid', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Ireland', 'Male', 'Postoperative Complications', 'Retrospective Studies', 'Stents', 'Treatment Outcome'] | 24,838,046 | [['M01.060.116.100'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E04.100.814.456.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.50... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The reactivity of Mg-substituted horseradish peroxidases. | Mg-substituted horseradish peroxidases were oxidized by K2IrCl6 or K3Fe(CN)6 to their porphyrin radical form and the 1:1 stoichiometric relationship was confirmed by spectrophotometric, fluorophotometric, and ESR titration methods. The values of E'0 for oxidations of Mg peroxidases A and C were both 0.63 V at pH 6 and ... | ['Electron Spin Resonance Spectroscopy', 'Horseradish Peroxidase', 'Hydrogen-Ion Concentration', 'Kinetics', 'Magnesium', 'Microscopy, Fluorescence', 'Oxidation-Reduction', 'Peroxidases', 'Photolysis', 'Spectrophotometry'] | 6,288,689 | [['E05.196.867.519.274'], ['D08.811.682.732.512'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['E01.370.350.515.458', 'E05.595.458'], ['G02.700', 'G03.295.531'], ['D08.811.682.732'], ['G02.740.685'], ['E05.196.712.726', 'E05.196.867.826']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A tuberculosis project in Ecuador]. | OBJECTIVE: Determination of the frequency of pulmonary tuberculosis in an Indian community in Ecuador among symptomatic patients and contacts of patients with tuberculosis. Pulmonary tuberculosis was defined as the presence of acid fast rods in sputum.SETTING: Pontificia Universidad Catolica del Ecuador, Quito, Ecuador... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Ecuador', 'Epidemiologic Methods', 'Female', 'Humans', 'Indians, South American', 'Male', 'Mass Screening', 'Middle Aged', 'Mycobacterium tuberculosis', 'Population Surveillance', 'Sputum', 'Tuberculosis, Pulmonary'] | 1,758,504 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['Z01.107.757.362'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.625'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation. | BACKGROUND: K(ATP) channels, activated by ischemia, participate in the arrhythmogenic response to acute coronary occlusion. The function of these channels in border zones of healing infarcts, where arrhythmias also arise, has not been investigated. Do these channels remain maximally activated during infarct healing, or... | ['Animals', 'Blood Pressure', 'Disease Models, Animal', 'Dogs', 'Dose-Response Relationship, Drug', 'Electric Stimulation', 'Electrocardiography', 'Electrodes', 'Electrophysiologic Techniques, Cardiac', 'Fluorescent Dyes', 'Heart', 'Heart Conduction System', 'Injections, Intra-Arterial', 'Myocardial Infarction', 'Pinac... | 12,010,915 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.723.402'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E07.305.250'], ['E01.370.370.380.245', 'E01.370.405.267'], ['D27.72... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microbiological contamination of pig carcasses at different stages of slaughter in two European Union-approved abattoirs. | At sequential steps of slaughter (scalding, dehairing, singeing, polishing, trimming, washing, and chilling), 200 pig carcasses from two abattoirs were examined for total viable bacteria count (TVC) and the presence of Enterobacteriaceae and coagulase-positive Staphylococcus (CPS) by the wet-dry double-swab technique a... | ['Abattoirs', 'Animals', 'Colony Count, Microbial', 'Enterobacteriaceae', 'European Union', 'Food Contamination', 'Food Handling', 'Food Microbiology', 'Meat', 'Staphylococcus', 'Swine'] | 17,133,797 | [['J01.576.423.200.700.100', 'J03.540.020'], ['B01.050'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B03.440.450.425', 'B03.660.250.150'], ['I01.615.500.475'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['J01.576.423.200'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300'... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Genetic and developmental analysis of some new color mutants in the goldfish, Carassius auratus. | The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp1 and Dp2, and only fish with do... | ['Albinism', 'Animals', 'Chromosome Mapping', 'Crosses, Genetic', 'Cyprinidae', 'Female', 'Genes, Dominant', 'Genes, Recessive', 'Genotype', 'Goldfish', 'Male', 'Melanophores', 'Mutation', 'Phenotype', 'Pigmentation', 'Retinal Pigments'] | 885,340 | [['C11.270.040', 'C16.320.290.040', 'C16.320.565.100.102', 'C16.320.850.080', 'C17.800.621.440.102', 'C17.800.827.080', 'C18.452.648.100.102'], ['B01.050'], ['E05.393.183'], ['E05.393.281'], ['B01.050.150.900.493.200.244'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.415', 'G05.420.325'], ['G05.38... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Seasonal fluctuation in peptic ulcer occurrence: a disappearing phenomenon?]. | Some studies suggest that seasonal fluctation of peptic ulcer occurrence is not common these days. The retrospective analysis of 4858 endoscopies performed in Srodmiejski Hospital in Warsaw confirmed this conclusion. There is no significant differences in frequency of peptic ulcer occurrence in particular seasons. | ['Humans', 'Peptic Ulcer', 'Poland', 'Retrospective Studies', 'Seasons'] | 9,770,999 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.275.800', 'C06.405.748.586'], ['Z01.542.248.679'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['G01.910.645.661', 'G16.... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Clofazimine Induced Suicidal Death of Human Erythrocytes. | BACKGROUND/AIMS: The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis. In erythrocytes phospholipase A2 stimulates eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphati... | ['Adenosine Triphosphate', 'Annexin A5', 'Calcium', 'Cell Death', 'Cell Size', 'Clofazimine', 'Cytosol', 'Erythrocyte Membrane', 'Erythrocytes', 'Hemoglobins', 'Hemolysis', 'Humans', 'Oxidative Stress', 'Phosphatidylserines', 'Phospholipases A2', 'Quinacrine', 'Reactive Oxygen Species'] | 26,316,080 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D12.776.157.125.050.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.146'], ['G04.325'], ['D03.633.300.704.353'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['A11.118.290.270', 'A11.284.149.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells. | Protein-coated resorbable synthetic polymeric nanofibrous membranes are promising for the fabrication of advanced skin substitutes. We fabricated electrospun polylactic acid and poly(lactide-co-glycolic acid) nanofibrous membranes and coated them with fibrin or collagen I. Fibronectin was attached to a fibrin or collag... | ['Cell Adhesion', 'Cell Proliferation', 'Cells, Cultured', 'Collagen', 'Extracellular Matrix', 'Fibrin', 'Fibroblasts', 'Fibronectins', 'Humans', 'Keratinocytes', 'Nanofibers', 'Polymers', 'Tensile Strength', 'Tissue Engineering', 'Tissue Scaffolds'] | 28,223,803 | [['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.284.295.310'], ['D12.776.124.270'], ['A11.329.228'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.4... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Robustness, variability, phase dependence, and longevity of individual synaptic input effects on spike timing during fluctuating synaptic backgrounds: a modeling study of globus pallidus neuron phase response properties. | A neuron's phase response curve (PRC) shows how inputs arriving at different times during the spike cycle differentially affect the timing of subsequent spikes. Using a full morphological model of a globus pallidus (GP) neuron, we previously demonstrated that dendritic conductances shape the PRC in a spike frequency-de... | ['Action Potentials', 'Globus Pallidus', 'Humans', 'Models, Neurological', 'Neurons', 'Synapses'] | 22,659,567 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['A08.186.211.200.885.287.249.487.397'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.642'], ['A08.675', 'A11.671'], ['A08.850', 'A11.284.149.165.420.780']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion. | The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/repe... | ['Animals', 'Biological Transport, Active', 'Cell Respiration', 'Cell Survival', 'Intracellular Membranes', 'Ischemic Preconditioning', 'Lactic Acid', 'Male', 'Mitochondria', 'Myocardial Reperfusion Injury', 'Oxidation-Reduction', 'Oxidative Phosphorylation', 'Protons', 'Rats', 'Rats, Wistar'] | 16,245,370 | [['B01.050'], ['G03.143.310'], ['G03.197', 'G04.270'], ['G04.346'], ['A11.284.149.450', 'A11.284.835.514'], ['E02.592', 'E05.516'], ['D02.241.511.459.450'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.877.500'], ['G02.700'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of normal aging on the manipulation of information in working memory. | The goal of this study is to examine the central executive of working memory in normal aging, specifically focusing on its capacities to manipulate or modify the format of the to-be-recalled material. The central executive was measured with the alphabetical span procedure, during which subjects were asked to recall a r... | ['Adult', 'Aged', 'Aging', 'Female', 'Humans', 'Male', 'Mental Recall', 'Middle Aged', 'Reference Values', 'Serial Learning'] | 9,610,125 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.641'], ['M01.060.116.630'], ['E05.978.810'], ['F02.463.425.952.747']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of tracheal intubation with the Airway Scope or Clarus Video System in patients with cervical collars. | Tracheal intubations with the Airway Scope or the Clarus Video System, a new rigid fibrescope, were compared in 140 patients whose necks were immobilised by cervical collars. The time for intubation, success rate, number of attempts and number of optimisation manoeuvres were assessed. Mean (SD) intubation time was long... | ['Adult', 'Aged', 'Braces', 'Cervical Vertebrae', 'Equipment Design', 'Female', 'Fiber Optic Technology', 'Humans', 'Intubation, Intratracheal', 'Laryngoscopes', 'Male', 'Middle Aged', 'Time Factors', 'Video Recording', 'Young Adult'] | 21,564,045 | [['M01.060.116'], ['M01.060.116.100'], ['E07.858.442.743.319'], ['A02.835.232.834.151'], ['E05.320'], ['H01.671.617.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['E07.230.220.525', 'E07.858.240.525'], ['M01.060.116.630'], ['G01.910.857'], ['L01.280.960'], ['M01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
The necessity for a thoracic approach in thyroid surgery. | HYPOTHESIS: A thoracic approach is commonly required in certain subsets of patients with a mediastinal thyroid mass.DESIGN: A retrospective review.SETTING: A tertiary referral center.PATIENTS: Nine hundred seventy-six consecutive patients who underwent thyroid surgery by a single surgeon from June 1, 1991, to March 30,... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Thoracic Neoplasms', 'Thoracic Surgical Procedures', 'Thyroid Diseases'] | 10,768,714 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['C04.... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Double the Trouble When Herpesviruses Join Hands. | KSHV is the etiologic agent of PEL-an aggressive lymphoma. Interestingly, EBV concurrently exists in nearly 70% of PEL cases. In this issue of Cell Host & Microbe, McHugh et al. (2017) develop humanized mouse models for EBV/KSHV co-infection and identify their complementary effect on in vivo tumor formation. | ['Animals', 'Coinfection', 'Disease Models, Animal', 'Epstein-Barr Virus Infections', 'Gene Expression Regulation, Viral', 'HIV', 'HIV Infections', 'Herpesviridae', 'Herpesviridae Infections', 'Herpesvirus 4, Human', 'Herpesvirus 8, Human', 'Humans', 'Lymphoma', 'Lymphoma, Primary Effusion', 'Mice', 'Sarcoma, Kaposi'] | 28,704,653 | [['B01.050'], ['C01.218'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C01.925.256.466.313', 'C01.925.928.313'], ['G05.308.385'], ['B04.820.650.589.650.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.280.382'], ['C01.925.256.4... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phytoextraction of arsenic from soil by Leersia oryzoides. | The potential of Leersia oryzoides (rice-cut grass) to remediate arsenic-contaminated soil was studied in greenhouse pot experiments. Leersia oryzoides grown in soil amended with arsenic to a concentration of 110 mg kg(-1), extracted up to 305 mg kg(-1) and 272 mg kg(-1) arsenic into its shoots and roots, respectively,... | ['Arsenic', 'Plant Roots', 'Plant Shoots', 'Poaceae', 'Soil'] | 18,246,713 | [['D01.268.513.249'], ['A18.400'], ['A18.024.875'], ['B01.650.940.800.575.912.250.822'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Erythema-multiforme-like eruption due to topical contactants: expression of adhesion molecules and their ligands and characterization of the infiltrate. | Erythema-multiforme-like reactions are a rare manifestation of allergic contact sensitivity, the pathomechanisms of which and their possible relationship to erythema multiforme remain unclear. We present our histopathological and immunohistochemical findings regarding the expression of several adhesion molecules and im... | ['Adult', 'Antigens, CD', 'Antigens, Differentiation, T-Lymphocyte', 'CD4-Positive T-Lymphocytes', 'Cell Adhesion Molecules', 'Dermatitis, Allergic Contact', 'Eosinophils', 'Erythema Multiforme', 'Exocytosis', 'Female', 'Gene Expression Regulation', 'Herpes Simplex', 'Humans', 'Immunophenotyping', 'Integrins', 'Interce... | 8,565,488 | [['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.894', 'D23.101.100.894'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['C17.800.174.255.100', 'C17.800.815.255.100', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Refining Emergency Severity Index triage criteria. | OBJECTIVES: The Emergency Severity Index (ESI) version 3 is a five-level triage acuity scale with demonstrated reliability and validity. Patients are rated from ESI level 1 (highest acuity) to ESI level 5 (lowest acuity). Clinical experience has demonstrated two levels of ESI level 2 patients: those who require immedia... | ['Confidence Intervals', 'Emergency Medicine', 'Emergency Nursing', 'Female', 'Humans', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Prospective Studies', 'Reproducibility of Results', 'Severity of Illness Index', 'Triage'] | 15,930,399 | [['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['H02.403.250'], ['H02.478.676.200', 'N02.421.533.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.761.559', 'N05.715.360.575'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Does the Iliac Wing Influence L5 Pedicle Screw Fixation? | OBJECTIVE: To explore whether the iliac wing influences L5 pedicle screw (PS) fixation and to propose methods to reduce such influence.METHODS: A total of 100 computed tomography scans (from 50 male and 50 female patients) of the lower lumbar region and pelvis were obtained and 3-dimensionally reconstructed. Cylinders ... | ['Anthropometry', 'Female', 'Humans', 'Ilium', 'Imaging, Three-Dimensional', 'Lumbar Vertebrae', 'Male', 'Pedicle Screws', 'Sex Characteristics', 'Spinal Fusion', 'Tomography, X-Ray Computed'] | 29,452,313 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.825.434'], ['E01.370.350.400', 'L01.224.308.410'], ['A02.835.232.834.519'], ['E07.695.370.437.500', 'E07.858.442.660.460.437.500', 'E07.858.690.725.460.437.500'], ['G08.686.815'], ['E04.555.100.700... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Relationship between Tetracyclines' Structure and Minimal Inhibitory Concentration of Streptococcus spp. | During the past years, a growing number of bacterial strains have become resistant to tetracyclines. The problem of increasing resistance and lack of susceptibility to tetracyclines applies to strains isolated from both: animals and humans. Basic tools to design new drugs and determining the direction of the search for... | ['Anti-Bacterial Agents', 'Microbial Sensitivity Tests', 'Software', 'Streptococcus', 'Tetracyclines'] | 25,153,336 | [['D27.505.954.122.085'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['L01.224.900'], ['B03.353.750.737.872', 'B03.510.400.800.872', 'B03.510.550.737.872'], ['D02.455.426.559.847.562.900', 'D04.615.562.900']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Preparation of compound biodegradable matrices and growth of vascular endothelial cell on them]. | OBJECTIVE: To prepare the compound biodegradable matrices, polyglycolic acid (PGA), polylactic acid (PLA) mesh and poly-beta-hydroxybutyrate(PHB) which precoated with collagen, and to observe the growth and differentiation of bovine vascular endothelial cells on these scaffolds.METHODS: By enzymatic digestion methods, ... | ['Animals', 'Biocompatible Materials', 'Cattle', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Division', 'Collagen', 'Endothelium, Vascular', 'Hydroxybutyrates', 'Polyesters', 'Polyglycolic Acid', 'Polymers', 'Tissue Engineering'] | 12,569,799 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A07... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis. | Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance-determining regions of both DNA gyrase (GyrA) and topoisomerase IV ... | ['Anti-Infective Agents', 'Bacterial Proteins', 'DNA Gyrase', 'DNA Topoisomerase IV', 'DNA Topoisomerases, Type II', 'DNA-Binding Proteins', 'Drug Resistance, Microbial', 'Fluoroquinolones', 'Humans', 'Microbial Sensitivity Tests', 'Mutation', 'Mycoplasma hominis'] | 10,103,208 | [['D27.505.954.122'], ['D12.776.097'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['D08.811.399.403.741.224', 'D12.776.097.256'], ['D08.811.399.403.741'], ['D12.776.260'], ['G06.225', 'G07.690.773.984.269'], ['D03.633.100.810.835.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1. | The MDR-involved human GSTA1-1, an important isoenzyme overexpressed in several tumors leading to chemotherapeutic-resistant tumour cells, has been targeted by 2,2'-dihydroxybenzophenones and some of their carbonyl N-analogues, as its potential inhibitors. A structure-based library of the latter was built-up by a nucle... | ['Benzophenones', 'Binding Sites', 'Catalytic Domain', 'Cell Line, Tumor', 'Cell Survival', 'Enzyme Inhibitors', 'Glutathione Transferase', 'Humans', 'Isoenzymes', 'Kinetics', 'Molecular Docking Simulation', 'Protein Binding', 'Structure-Activity Relationship', 'Thermodynamics'] | 25,002,233 | [['D02.455.426.559.389.134', 'D02.522.223'], ['G02.111.570.120'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D27.505.519.389'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['G01.374.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cigarette smoking behaviors among adults with serious mental illness in a nationally representative sample. | PURPOSE: This study updates nationally representative information on cigarette smoking behaviors among adults with mental illness, particularly serious mental illness (SMI), to serve as a new benchmark for smoking cessation initiatives.METHODS: Data are from the 2008-2012 National Surveys on Drug Use and Health. Preval... | ['Adolescent', 'Adult', 'Age Distribution', 'Comorbidity', 'Cross-Sectional Studies', 'Female', 'Health Surveys', 'Humans', 'Interviews as Topic', 'Male', 'Mental Disorders', 'Mentally Ill Persons', 'Middle Aged', 'Prevalence', 'Smoking', 'Tobacco Use Disorder', 'United States', 'Young Adult'] | 25,169,683 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Acid Suppression in Neonates: Friend or Foe? | Medications that reduce gastric acid secretion are commonly prescribed for treating gastroesophageal reflux disease. However, several studies have shown that these medications are not very effective, and are associated with adverse effects. This article discusses the physiology of gastric acid secretion, clinical indic... | ['Antacids', 'Gastroesophageal Reflux', 'Gastrointestinal Tract', 'Humans', 'Infant Nutritional Physiological Phenomena', 'Infant, Newborn', 'Neonatology', 'Patient Care Management'] | 31,333,204 | [['D27.505.519.170', 'D27.505.954.483.080'], ['C06.405.117.119.500.484'], ['A03.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.220.500'], ['M01.060.703.520'], ['H02.403.670.400'], ['N04.590']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
A new screening method for flunitrazepam in vodka and tequila by fluorescence spectroscopy. | A new screening method for flunitrazepam in colourless alcoholic beverages based on a spectroscopic technique is proposed. Absorption and steady-state fluorescence of flunitrazepam and its protonated form with various acids were investigated. The redshift of the wavelength of maximum absorption was distinctively observ... | ['Alcoholic Beverages', 'Flunitrazepam', 'Hypnotics and Sedatives', 'Spectrometry, Fluorescence'] | 22,354,877 | [['G07.203.100.100', 'J02.200.100'], ['D03.633.100.079.080.070.320'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of endotoxins and enzymes in vitro on the release of gingival histamine. | Gingival samples removed from fifteen Beagle dogs were sectioned into small pieces, parts of which served as the uncultured piece; the remaining pieces were organ cultured for four hours at 37 degrees C in MEM control, compound 48/80, endotoxins, protease, collagenase, hyaluronidase, trypsin and chymotrypin media. Uncu... | ['Animals', 'Chymotrypsin', 'Dogs', 'Dose-Response Relationship, Drug', 'Endotoxins', 'Enzymes', 'Gingiva', 'Histamine Release', 'Hyaluronoglucosaminidase', 'Microbial Collagenase', 'Peptide Hydrolases', 'Trypsin', 'p-Methoxy-N-methylphenethylamine'] | 52,703 | [['B01.050'], ['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D23.946.123.329'], ['D08.811'], ['A14.549.167.646.480'], ['G12.350'], ['D08.811.277.450.529', 'D08.811.520.241.700.675'], ['D08.811.277.656.300.480.205.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of TNF-á-308 and -238 polymorphisms with risk of cervical cancer: a meta-analysis. | Published data on the associations between tumor necrosis factor-alpha (TNF-á) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds r... | ['Case-Control Studies', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Polymorphism, Single Nucleotide', 'Prognosis', 'Risk Factors', 'Tumor Necrosis Factor-alpha', 'Uterine Cervical Neoplasms'] | 23,317,256 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['E01.789'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Ability of vancomycin-group antibiotics to induce or to inhibit thrombocyte agglutination]. | The effect of 4 vancomycin antibiotics on factor VIII-dependent agglutination of thrombocytes was studied. Significant similarity, both quantitative and qualitative, between ristocetin and ristomycin was found. In this connection ristomycin may be used for determination of the so-called ristocetin cofactor. Actinoidin ... | ['Dose-Response Relationship, Drug', 'Drug Interactions', 'Factor VIII', 'Female', 'Humans', 'Male', 'Platelet Aggregation', 'Ristocetin', 'Structure-Activity Relationship', 'Vancomycin'] | 6,250,464 | [['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['D12.776.124.125.350', 'D12.776.811.286', 'D23.119.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D09.400.420.800', 'D12.644.233.697'], ['G02.111.830', 'G07.690.773.997'], ['D09.400.420.925', 'D12.644.2... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Proteomic Characterization of Caenorhabditis elegans Larval Development. | The nematode Caenorhabditis elegans is widely used as a model organism to study cell and developmental biology. Quantitative proteomics of C. elegans is still in its infancy and, so far, most studies have been performed on adult worm samples. Here, we used quantitative mass spectrometry to characterize protein level ch... | ['Animals', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Larva', 'Proteomics', 'Tandem Mass Spectrometry'] | 29,178,193 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['E05.196.566.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Scope of contemporary pharmacy practice: roles, responsibilities, and functions of pharmacists and pharmacy technicians. | OBJECTIVE: To provide an overview of the current context and scope of pharmacy practice, the range of professional services offered by pharmacists, and the supporting role of pharmacy technicians.DATA SYNTHESIS: A synopsis of the current state of pharmacy practice as it relates to the spectrum of professional roles and... | ['Education, Pharmacy', 'Job Description', 'Licensure, Pharmacy', 'Medication Therapy Management', 'Pharmaceutical Services', 'Pharmacists', 'Pharmacy', 'Pharmacy Technicians', 'Professional Competence', 'Professional Role', 'United States', 'Workforce'] | 20,199,947 | [['I02.358.525'], ['N04.452.677.410'], ['N03.706.110.510.560', 'N05.700.200.450.625'], ['N02.421.668.438', 'N03.219.521.576.343.575.500.500', 'N03.219.521.576.343.840.938.500', 'N04.590.661'], ['N02.421.668'], ['M01.526.485.780', 'N02.360.780'], ['H02.646'], ['M01.526.485.067.735', 'N02.360.067.730'], ['I02.399.630'], ... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Blue light is required for survival of the tomato phytochrome-deficient aurea mutant and the expression of four nuclear genes coding for plastidic proteins. | When dark-grown aurea mutant tomato seedlings which lack more than 95% of the phytochrome present in isogenic wild-type seedlings are kept in white or blue light, four nuclear-encoded transcripts coding for plastidic proteins (the light-harvesting chlorophyll a/b-binding protein of photosystem I and II [cab-PSII], plas... | ['Gene Expression Regulation', 'Light', 'Light-Harvesting Protein Complexes', 'Morphogenesis', 'Mutation', 'Photosynthesis', 'Photosynthetic Reaction Center Complex Proteins', 'Photosystem I Protein Complex', 'Phytochrome', 'Plant Development', 'Plant Proteins', 'Plants', 'Plastocyanin', 'RNA'] | 1,716,500 | [['G05.308'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D05.500.562.488.490', 'D08.811.600.710.490', 'D12.776.543.930.500.490', 'D12.776.765.199.750.750.490'], ['G07.345.500'], ['G05.365.590'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Familial cavernous angiomas masquerading as multiple sclerosis. | We report here two cases of cavernous angioma, in the proband and her father, with quite different clinical presentations. The proband presented with a brainstem syndrome, mimicking multiple sclerosis, while the father had a history of mild epilepsy. Both patients were managed conservatively. The cases also demonstrate... | ['Adult', 'Brain Neoplasms', 'Diagnosis, Differential', 'Female', 'Hemangioma, Cavernous', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis'] | 9,926,126 | [['M01.060.116'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E01.171'], ['C04.557.645.375.385', 'C14.907.454.385', 'C15.378.463.515.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. | Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that serves as a key regulator of cellular differentiation and survival. Immune stimuli increase S1P synthesis and secretion by mast cells and platelets, implicating this molecule in tissue responses to injury and inflammation. Binding of S1P to G(... | ['Animals', 'Cell Hypoxia', 'Cell Survival', 'Cells, Cultured', 'GTP-Binding Protein alpha Subunits, Gi-Go', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Myocytes, Cardiac', 'Phosphatidylinositol 3-Kinases', 'Proto-Oncogene Proteins c-akt', 'Receptors, Lysosphingolipid', 'Signal Transduction'] | 17,766,476 | [['B01.050'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['A11.251'], ['D08.811.277.040.330.300.200.100.200', 'D12.644.360.360.100.200', 'D12.776.157.325.332.100.200', 'D12.776.476.375.100.200', 'D12.776.543.325.100.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. | Physicochemical parameters that influence gas chromatographic separation are numerous. Consequently, isotope labelling, because it modifies physicochemical properties, can induce isotopic effects on retention time. Caffeine has been chosen to study this influence because as itself and its metabolites, it allows the pre... | ['Animals', 'Caffeine', 'Deuterium', 'Gas Chromatography-Mass Spectrometry', 'Isotope Labeling', 'Kidney', 'Male', 'Rats', 'Rats, Wistar', 'Theobromine', 'Theophylline', 'Uric Acid'] | 9,061,462 | [['B01.050'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['E05.196.181.349.500', 'E05.196.566.500'], ['E05.522'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D03.132.960.651', 'D03.633.10... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Implementation and Evaluation of the Abriendo Caminos Program: A Randomized Control Trial Intervention for Hispanic Children and Families. | OBJECTIVE: To describe the methodology of a family-focused, culturally tailored program, Abriendo Caminos, for the prevention of excess weight gain in children.DESIGN: Randomized control trial with outcome assessment at pretest, posttest, and 6 months after intervention or abbreviated-attention control group.SETTING: C... | ['Adolescent', 'Child', 'Curriculum', 'Diet', 'Exercise', 'Female', 'Health Promotion', 'Hispanic Americans', 'Humans', 'Male', 'Pediatric Obesity', 'Puerto Rico', 'United States', 'Weight Gain'] | 31,706,460 | [['M01.060.057'], ['M01.060.406'], ['I02.158'], ['G07.203.650.240'], ['G11.427.410.698.277', 'I03.350'], ['I02.233.332.445', 'N02.421.726.407.579'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500.720', 'C23.888.144.699.500.750', 'E01.370.600.115.100.160.120.699.500.750', 'G07.10... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Expression of melanoma antigen gene by cells from inflamed joints in juvenile rheumatoid arthritis. | OBJECTIVE: To determine if synovial fluid (SF) cells from inflamed joints of patients with juvenile rheumatoid arthritis (JRA) express melanoma antigen gene (MAGE) RNA and protein.METHODS: The pattern of MAGE-A1 expression was analyzed in inflammatory synovial tissue and peripheral blood mononuclear cells (PBMC) from p... | ['Adolescent', 'Antigens, Neoplasm', 'Arthritis, Juvenile', 'Biomarkers', 'Child', 'Female', 'Flow Cytometry', 'Fluorescent Antibody Technique', 'Humans', 'Immunoenzyme Techniques', 'Immunoglobulin G', 'Infant', 'Leukocytes, Mononuclear', 'Male', 'Melanoma-Specific Antigens', 'Neoplasm Proteins', 'RNA, Messenger', 'Rev... | 12,375,337 | [['M01.060.057'], ['D23.050.285'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['D23.101'], ['M01.060.406'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['E01.370.225.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. | We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B suggests that the NL... | ['Active Transport, Cell Nucleus', 'Animals', 'Crystallography, X-Ray', 'DNA Mutational Analysis', 'Histones', 'Humans', 'Karyopherins', 'Molecular Chaperones', 'Mutant Proteins', 'Protein Binding', 'Protein Conformation', 'Xenopus'] | 30,855,230 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['E05.196.309.742.225'], ['E05.393.760.700.300'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.750.500', 'D12.776.543.585.750.500', 'D12.776.660.502'], ['D12.776.580'], ['D12.77... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma. | LESSONS LEARNED: This study is a rare example of effective doses of both targeted agents being both administered and tolerated.This combination should not be used in melanoma.BACKGROUND: Sorafenib and bortezomib affect BCL family member expression. We previously demonstrated that bortezomib augmented sorafenib-mediated... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Bortezomib', 'Disease-Free Survival', 'Dose-Response Relationship, Drug', 'Drug-Related Side Effects and Adverse Reactions', 'Female', 'Humans', 'Male', 'Maximum Tolerated Dose', 'Melanoma', 'Middle Aged', 'Niacinamide', 'Phenylurea Compounds', 'Soraf... | 25,986,244 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is inefficient multisensory processing associated with falls in older people? | Although falling is a significant problem for older persons, little is understood about its underlying causes. Spatial cognition and balance maintenance rely on the efficient integration of information across the main senses. We investigated general multisensory efficiency in older persons with a history of falls compa... | ['Accidental Falls', 'Acoustic Stimulation', 'Adult', 'Age Factors', 'Aged', 'Aging', 'Analysis of Variance', 'Attention', 'Auditory Perception', 'Auditory Perceptual Disorders', 'Case-Control Studies', 'Female', 'Humans', 'Illusions', 'Male', 'Photic Stimulation', 'Psychoacoustics', 'Visual Perception', 'Young Adult'] | 21,293,851 | [['N06.850.135.122'], ['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['G07.345.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.830.104.214'], ['F02.463.593.071', 'G07.888.125'], ['C09.218.807.186.094', 'C10.228... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. | BACKGROUND: Osteogenic and chondrocytic differentiation involves a cascade of coordinated transcription factor gene expression that regulates proliferation and matrix protein formation in a defined temporo-spatial manner. Bone morphogenetic protein-2 induces expression of the murine Osterix/Specificity protein-7 (Sp7) ... | ['Alternative Splicing', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'Cell Line, Tumor', 'Chondrocytes', 'Chromosome Mapping', 'Chromosomes, Human, Pair 12', 'DNA, Complementary', 'Female', 'Gene Expression', 'Humans', 'Male', 'Mice', 'Molecular Sequence Data', 'Osteoblasts', 'Phylogeny', 'Protein I... | 14,604,442 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.329.171'], ['E05.393.183'], ['A11.284.187.520.300.325.360', 'G05.360.162.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. | The E5 protein of bovine papillomavirus type 1 binds to and activates the endogenous platelet-derived growth factor (PDGF) beta receptor in fibroblasts, resulting in cell transformation. We have developed a functional assay to test the ability of PDGF beta receptor mutants to mediate a mitogenic signal initiated by the... | ['Animals', 'Binding Sites', 'Bovine papillomavirus 1', 'Cell Division', 'Cell Line', 'Humans', 'Ligands', 'Mice', 'Mitogens', 'Mutation', 'Oncogene Proteins, Viral', 'Phosphorylation', 'Protein-Tyrosine Kinases', 'Receptors, Platelet-Derived Growth Factor', 'Signal Transduction'] | 7,739,538 | [['B01.050'], ['G02.111.570.120'], ['B04.280.210.655.200.100', 'B04.613.204.655.200.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['B01.050.150.900.649.313.992.635.505.500'], ['D27.505.519.593.624']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uranium isotopic ratio measurements of U3O8 reference materials by atom probe tomography. | We report results of measurements of isotopic ratios obtained with atom probe tomography on U3O8 reference materials certified for their isotopic abundances of uranium. The results show good agreement with the certified values. High backgrounds due to tails from adjacent peaks complicate the measurement of the integrat... | ['Oxides', 'Radiation Monitoring', 'Radioactive Pollutants', 'Reproducibility of Results', 'Tomography', 'Uranium Compounds'] | 26,774,651 | [['D01.248.497.158.685', 'D01.650.550'], ['E05.799.638', 'N06.850.780.375.700', 'N06.850.810.370'], ['D20.693'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E01.370.350.825'], ['D01.950']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of Wet Macular Degeneration on the Execution of Natural Actions. | PURPOSE: To use eye movements to investigate how people with a central scotoma might be impaired in the execution of natural actions and whether task familiarity affects performance.METHODS: Sixteen participants with AMD and 16 age-matched controls performed two natural actions: (1) a familiar sandwich-making task and ... | ['Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Eye Movement Measurements', 'Eye Movements', 'Female', 'Fixation, Ocular', 'Humans', 'Male', 'Psychomotor Performance', 'Time Factors', 'Wet Macular Degeneration'] | 26,513,497 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.380.230', 'E01.370.405.245.787'], ['G11.427.410.140', 'G14.350'], ['G14.350.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['G01.910... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Child labour in Egypt. II. Impact of work environment on health. | The studied population (1000 children and young workers and 250 controls) were interviewed for health complaints and subjected to extensive medical investigations. Health problems are more encountered among the workers than in the controls, which has been attributed to the impact of work on health and to the low socioe... | ['Adolescent', 'Adult', 'Child', 'Egypt', 'Employment', 'Female', 'Health Status Indicators', 'Humans', 'Interviews as Topic', 'Male', 'Occupational Health'] | 17,265,656 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['Z01.058.266.317'], ['N01.824.245'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['N0... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. | Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unknown how synaptic act... | ['Amino Acid Transport System X-AG', 'Animals', 'Astrocytes', 'Enzyme Inhibitors', 'Excitatory Amino Acid Agents', 'GABA Agents', 'Glial Fibrillary Acidic Protein', 'Inhibitory Postsynaptic Potentials', 'Interleukin 1 Receptor Antagonist Protein', 'Interleukin-1beta', 'Lipopolysaccharides', 'Male', 'Minocycline', 'Rats... | 25,571,780 | [['D12.776.157.530.200.249.500', 'D12.776.157.530.937.250', 'D12.776.543.585.200.249.500', 'D12.776.543.585.937.250'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['D27.505.519.389'], ['D27.505.519.625.190', 'D27.505.696.577.190'], ['D27.505.519.625.240', 'D27.505.696.577.240'], ['D05.750.078.593.400', 'D12.776.220.47... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Higher sensitivity of male CD4+ T cells to suppressive effects of CD8+ T cells on IL-5 production compared to female CD4+ T cells. | BACKGROUND: Asthma prevalence and severity are higher in females than in males after puberty. The underlying mechanisms of this gender difference are not fully understood. More severe airway inflammation in female mice has been reported to be associated with higher levels of T helper type 2 (Th2) cytokines in asthma mo... | ['Animals', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Female', 'Interleukin-5', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Receptors, Antigen, T-Cell', 'Sex Factors', 'Spleen'] | 22,627,364 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['D12.644.276.374.465.202', 'D12.776.467.374.465.186', 'D23.529.374.465.202'], ['B01.050.150.900.649.313.992... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Issues, and the questions they inspire, when one considers the development of European higher education for health care professionals. | This paper highlights various aspects of an emerging European health strategy and the potential consequences this may bring. The various directives of the European Commission, ratified by the European Parliament and each of the Parliaments of the member states, are gently and progressively forging integration of system... | ['Clinical Competence', 'Curriculum', 'Delivery of Health Care', 'Education, Graduate', 'European Union', 'Health Personnel', 'Humans', 'National Health Programs', 'Quality Assurance, Health Care'] | 19,753,391 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['N04.590.374', 'N05.300'], ['I02.358.337'], ['I01.615.500.475'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.550'], ['N04.761.700', 'N05.700']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Ab initio prediction of mutation-induced cryptic splice-site activation and exon skipping. | Mutations that affect splicing of precursor messenger RNAs play a major role in the development of hereditary diseases. Most splicing mutations have been found to eliminate GT or AG dinucleotides that define the 5' and 3' ends of introns, leading to exon skipping or cryptic splice-site activation. Although accurate des... | ['Algorithms', 'Exons', 'Mutation', 'RNA Splice Sites', 'RNA Splicing'] | 19,142,208 | [['G17.035', 'L01.224.050'], ['G05.360.340.024.340.137.232'], ['G05.365.590'], ['D13.444.735.544.550', 'G02.111.570.080.689.687.490', 'G05.360.080.689.687.490', 'G05.360.340.024.340.137.800'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.700']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Beyond rambling and trembling: effects of visual feedback on slow postural drift. | We explored one of the unusual predictions of the concept of back-coupling within the theoretical scheme of the control of posture and movement with setting referent coordinates for the effectors. This concept implies slow drifts of referent coordinates toward actual coordinates leading to unintentional drift in perfor... | ['Adult', 'Biomechanical Phenomena', 'Feedback, Sensory', 'Female', 'Humans', 'Male', 'Postural Balance', 'Visual Perception', 'Young Adult'] | 30,635,703 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['F04.754.137.301.500', 'F04.754.308.500.500', 'F04.754.339', 'G07.410.732.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.561.790.541.595'], ['F02.463.593.932'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adequacy of Inclusion of Older Adults in NIH-Funded Phase III Clinical Trials. | In the United States, the population aged 65 and older is rapidly growing, and this group uses more healthcare resources and has unique healthcare needs that do not exist in younger populations. However, it was reported that older adults are excluded or underrepresented in clinical trials for several diseases. We exami... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Clinical Trials, Phase III as Topic', 'Female', 'Humans', 'Male', 'National Institutes of Health (U.S.)', 'Patient Selection', 'Research Subjects', 'Research Support as Topic', 'United States'] | 30,693,958 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.250.250.220', 'N05.715.360.330.250.250.220', 'N06.850.520.450.250.250.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.409.418.750.600.650.496', 'N03.540.052.750', 'N03.540.348.500.500.600.650.496'], ['E05.... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Dynamics of embryonic pancreas development using real-time imaging. | Current knowledge about developmental processes in complex organisms has relied almost exclusively on analyses of fixed specimens. However, organ growth is highly dynamic, and visualization of such dynamic processes, e.g., real-time tracking of cell movement and tissue morphogenesis, is becoming increasingly important.... | ['Animals', 'Biomarkers', 'Cell Movement', 'Embryo Culture Techniques', 'Female', 'Green Fluorescent Proteins', 'Hedgehog Proteins', 'Homeodomain Proteins', 'Insulin', 'Insulin-Secreting Cells', 'Mice', 'Mice, Transgenic', 'Morphogenesis', 'Organogenesis', 'Pancreas', 'RNA, Messenger', 'Signal Transduction', 'Trans-Act... | 17,448,459 | [['B01.050'], ['D23.101'], ['G04.198', 'G07.568.500.180'], ['E05.481.500.468'], ['D12.776.532.265'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['D12.776.260.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', 'A11.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. | A study to determine whether the bronchoconstriction induced by low concentration of sulfur dioxide in subjects with asthma decreases with repeated exposure was undertaken. Eight subjects with asthma performed 3 min of voluntary eucapnic hyperpnea with 0.5 ppm of SO2 in humidified filtered air three times at 30-min int... | ['Adult', 'Airway Resistance', 'Asthma', 'Bronchi', 'Bronchial Provocation Tests', 'Drug Tolerance', 'Female', 'Histamine', 'Humans', 'Male', 'Sulfur Dioxide'] | 6,832,125 | [['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['A04.411.125'], ['E01.370.386.700.125'], ['G07.690.773.992'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Indiana continent catheterizable urinary reservoir. | INTRODUCTION: Radical pelvic surgery requires continent or incontinent urinary diversion. There are many techniques, but the orthotopic neobladder is the most used. A continent catheterizable urinary reservoir is sometimes a good alternative when this derivation is not possible or not indicated. This paper has aimed to... | ['Adult', 'Aged', 'Cystectomy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pelvic Exenteration', 'Retrospective Studies', 'Urinary Catheterization', 'Urinary Reservoirs, Continent'] | 24,791,619 | [['M01.060.116'], ['M01.060.116.100'], ['E04.950.774.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.584'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Bacterial strain characterizing by EDTA requirement]. | A novel strain of bacteria (LPM-4) was isolated that is characterized by a unique EDTA requirement for cell growth. Suspensions of washed cells of strain LPM-4 degrated EDTA complexes with Ba2+, Mg 2+, Ca2+, and Mn2+ at constant rates (0.310-0.486 mmol EDTA/(g h)) and Zn-EDTA at an initial rate of 0.137 +/- 0.016 mmol ... | ['Culture Media', 'Edetic Acid', 'Hydrogen-Ion Concentration', 'Proteobacteria', 'Sewage', 'Species Specificity', 'Temperature'] | 16,240,652 | [['D27.720.470.305', 'E07.206'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['G02.300'], ['B03.660'], ['D20.944.932.500'], ['G16.824'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
How to find the best evidence. | The Internet has made finding evidence for clinical practice fairly easy. Many different types of databases that can be searched for relevant key terms are available for free or for subscription. Bibliographic or library databases contain books, book chapters, reports, citations, abstracts, and either the full text of ... | ['Databases, Bibliographic', 'Evidence-Based Medicine', 'Humans', 'Respiratory Therapy'] | 19,796,416 | [['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880']] | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Toward a climate for work resumption: the nonmedical determinants of return to work. | OBJECTIVE: People who have been on long-term absence from work because of ill health usually have reduced chances to resume work again. Nevertheless, little is known about its causal factors. The aim of this study is to present and test an empirical model to predict return to work of employees who are long-term absent ... | ['Absenteeism', 'Adult', 'Depression', 'Disability Evaluation', 'Europe', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personnel Management', 'Self Efficacy', 'Sick Leave', 'Stress, Psychological'] | 20,042,881 | [['F02.784.692.107'], ['M01.060.116'], ['F01.145.126.350'], ['E01.370.400'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.452.677'], ['F01.752.747.792.700'], ['N01.824.417.700.662', 'N04.452.677.800.662'], ['F01.145.126.990', 'F02.830.900']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The determination of short-term breast volume changes and the rate of synthesis of human milk using computerized breast measurement. | The feasibility of using sequential breast volume measurements as a method of studying short-term rates of milk synthesis in women has been established. We have developed a rapid Computerized Breast Measurement system for the determination of breast volume, based upon the Shape Measurement System. A circle encompassing... | ['Breast', 'Breast Feeding', 'Computer Simulation', 'Female', 'Humans', 'Infant', 'Lactation', 'Milk, Human'] | 1,543,594 | [['A01.236'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G08.686.523', 'G08.686.702.500'], ['A12.200.467', 'A12.790.500', 'G07.203.100.700.500', 'G07.203.300.350.525.500', 'J02.200.700.500... | ['Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Inter-rater reliability of the neurological examination in schizophrenia. | Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabil... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neurocognitive Disorders', 'Neurologic Examination', 'Observer Variation', 'Reproducibility of Results', 'Schizophrenia', 'Schizophrenic Psychology'] | 9,516,670 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.615'], ['E01.370.376.550', 'E01.370.600.550'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis of the highly selective Na+/H+ exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate. | The syntheses of cariporide mesilate ((4-isopropyl-3-methanesulfonyl-benzoyl) guanidine methanesulfonate, HOE 642, CAS 159138-81-5), currently being clinically investigated as a protective drug in cardiac ischemia and reperfusion states, and of HOE 694 ((3-methanesulfonyl-4-piperidino-benzoyl)guanidine methanesulfonate... | ['Amiloride', 'Cell Line', 'Diuretics', 'Enzyme Inhibitors', 'Guanidines', 'Sodium-Hydrogen Exchangers', 'Sulfones'] | 9,428,974 | [['D03.383.679.149'], ['A11.251.210'], ['D27.505.696.560.500'], ['D27.505.519.389'], ['D02.078.370'], ['D12.776.157.530.450.162.775', 'D12.776.157.530.937.703', 'D12.776.543.550.190.775', 'D12.776.543.585.450.162.775', 'D12.776.543.585.937.828'], ['D02.886.590']] | ['Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Overproduction of flotillin influences cell differentiation and shape in Bacillus subtilis. | UNLABELLED: Bacteria organize many membrane-related signaling processes in functional microdomains that are structurally and functionally similar to the lipid rafts of eukaryotic cells. An important structural component of these microdomains is the protein flotillin, which seems to act as a chaperone in recruiting othe... | ['ATP-Dependent Proteases', 'Bacillus subtilis', 'Cell Division', 'Gene Expression', 'Membrane Proteins', 'Recombinant Proteins'] | 24,222,488 | [['D08.811.277.040.013.500.032', 'D08.811.277.040.025.024.032', 'D08.811.277.656.149', 'D12.776.157.025.750.032'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pro-inflammation NF-êB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells. | BACKGROUND: Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance in cancer cell physiology. This study was designed to investigate the relationship between inflammation and ch... | ['Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cholesterol', 'Feedback, Physiological', 'Gene Expression Regulation, Neoplastic', 'Hep G2 Cells', 'Humans', 'Hydroxymethylglutaryl CoA Reductases', 'Lipopolysaccharides', 'Liver Neoplasms', 'NF-kappa B', 'Proprotein Convertase 9', 'Receptors, LDL', 'Signal Transductio... | 28,100,270 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.410.732'], ['G05.308.370'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.11... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of a conscious versus anesthetized canine model in response to milrinone, hydralazine and nitroprusside. | The purpose of this study was to demonstrate, based on previous and new data, that the differences between a conscious and anesthetized canine model in the cardiovascular responses to cardiovasoactive agents were beyond their difference in the sensitivity of the compensatory mechanisms. In both conscious and anesthetiz... | ['Anesthesia', 'Animals', 'Blood Pressure', 'Cardiotonic Agents', 'Dogs', 'Dose-Response Relationship, Drug', 'Female', 'Heart Rate', 'Hemodynamics', 'Hydralazine', 'Isoproterenol', 'Male', 'Milrinone', 'Nitroprusside', 'Pulmonary Circulation', 'Pyridones'] | 8,231,457 | [['E03.155'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.954.411.222', 'D27.720.799.080'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['D03.383.710.605.500'], ['D02.033.100.291.439', 'D02.092.0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties. | Myotonic dystrophy (DM) is the most prevalent inherited neuromuscular disease in adults. The genetic defect is a CTG triplet repeat expansion in the 3'-untranslated region of the myotonic dystrophy protein kinase ( DMPK ) gene, consisting of 15 exons. Using a transgenic DMPK-overexpressor mouse model, we demonstrate he... | ['Alternative Splicing', 'Animals', 'COS Cells', 'DNA, Complementary', 'Exons', 'Humans', 'Isoenzymes', 'Male', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Myotonic Dystrophy', 'Myotonin-Protein Kinase', 'Protein Processing, Post-Translational', 'Protein-Serine-Threonine Kinases', 'RNA, Messenger', 'Reverse Transcri... | 10,699,184 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300']... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Familial ALS with SOD1 mutation misdiagnosed with polyradiculopathy and myopathy. | We report a 54-year-old male with progressive and asymmetrical lower extremity weakness caused by familial amyotrophic lateral sclerosis (FALS) with a Cu/Zn superoxidase dismutase 1 (SOD1) gene mutation. He was initially misdiagnosed with a lumbosacral polyradiculopathy because of spinal stenosis and underwent a lamine... | ['Amyotrophic Lateral Sclerosis', 'Diagnosis, Differential', 'Diagnostic Errors', 'Humans', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Muscular Diseases', 'Mutation', 'Polyradiculopathy', 'Superoxide Dismutase', 'Superoxide Dismutase-1'] | 19,922,143 | [['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['E01.171'], ['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.567', 'A10.690.552.500'], ['C05.651', 'C10.668.491'], ['G05.365.590'], ['C10.668.829.800.750.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. | Inappropriate expression of the multidrug resistance (MDR1) gene encoding the P-glycoprotein (Pgp) has been frequently implicated in resistance to different chemotherapeutic drugs. We have previously generated chronic myeloid leukemia (CML) cell lines resistant to the tyrosine kinase inhibitor imatinib mesylate (STI571... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Apoptosis', 'Benzamides', 'Cell Death', 'Cell Division', 'Colony-Forming Units Assay', 'Cyclosporins', 'Doxorubicin', 'Drug Resistance, Neoplasm', 'Flow Cytometry', 'Gene Expression', 'Genes, MDR', 'Humans', 'Imatinib Mesylate', 'Leukemia', 'Leukemia, Myeloge... | 12,609,962 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['G04.146.954.035'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['G04.146'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of Long-Term Outcomes in Real-World Patients Between Resolute Zotarilumus-Eluting and Paclitaxel-Eluting Stents in Small Vessel. | OBJECTIVE: To compare the long-term clinical outcomes between Resolute zotarolimus-eluting stent (R-ZES) and paclitaxel-eluting stent (PES) in patients with small coronary artery disease.BACKGROUND: Patients with a small vessel diameter are independently associated with increased risk of adverse cardiac events after dr... | ['Adult', 'Aged', 'Cardiovascular Agents', 'Coronary Artery Disease', 'Coronary Restenosis', 'Coronary Thrombosis', 'Drug-Eluting Stents', 'Female', 'Humans', 'Male', 'Middle Aged', 'Paclitaxel', 'Percutaneous Coronary Intervention', 'Retrospective Studies', 'Risk Factors', 'Sirolimus', 'Treatment Outcome'] | 26,483,572 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C14.280.647.250.285.200', 'C14.907.585.250.285.200'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['E07.695.750.500'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nonlinear stochastic system identification of skin using volterra kernels. | Volterra kernel stochastic system identification is a technique that can be used to capture and model nonlinear dynamics in biological systems, including the nonlinear properties of skin during indentation. A high bandwidth and high stroke Lorentz force linear actuator system was developed and used to test the mechanic... | ['Adolescent', 'Adult', 'Biomechanical Phenomena', 'Biomedical Engineering', 'Equipment Design', 'Female', 'Humans', 'Least-Squares Analysis', 'Male', 'Models, Biological', 'Nonlinear Dynamics', 'Skin Physiological Phenomena', 'Stochastic Processes', 'Young Adult'] | 23,264,003 | [['M01.060.057'], ['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['H02.070', 'J01.293.140'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.599.395'], ['E05.599.850', 'H01.548.675'], ['G13.750'], ['E05.318.740.996', 'G... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Linkage analysis between bipolar affective disorder and markers on chromosome X. | Since 1969, several classical linkage studies suggested an X-chromosome locus for bipolar affective disorder. However, methods using highly polymorphic DNA markers have provided conflicting evidence for linkage, and an X-chromosomal locus for bipolar disorder remains controversial. More recently, Pekkarinen et al. (199... | ['Bipolar Disorder', 'Brazil', 'England', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Lod Score', 'Male', 'Wales', 'X Chromosome'] | 9,800,220 | [['F03.084.500'], ['Z01.107.757.176'], ['Z01.542.363.300'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.348.750'], ['Z01.542.363.914'], ['A11.284.187.865.982', 'G05.360.162.865.982']] | ['Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Nedocromil sodium inhibits the increase in airway reactivity induced by platelet activating factor in humans. | To investigate the effect of nedocromil sodium on changes in airway reactivity to methacholine induced by platelet activating factor, we studied 12 nonasthmatic, nonatopic subjects (24 to 41 years) in a double-blind trial. The FEV1 and airflow at 30 percent of vital capacity from a partial forced expiration (V30p) were... | ['Adult', 'Anti-Inflammatory Agents, Non-Steroidal', 'Bronchial Hyperreactivity', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Forced Expiratory Volume', 'Humans', 'Male', 'Maximal Expiratory Flow-Volume Curves', 'Methacholine Chloride', 'Nedocromil', 'Platelet Activating Factor', 'Quinolones', 'Vital Ca... | 1,320,563 | [['M01.060.116'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C08.127.210'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Trihalomethane levels in drinking water in the province of Granada [Spain]]. | OBJECTIVES: Drinking water chlorination generates potentially harmful by-products, such as trihalomethanes. Trihalomethane levels are high in some parts of Spain. The aim of the present study was to investigate trihalomethane concentrations in drinking water from distinct water supplies in the province of Granada, with... | ['Spain', 'Trihalomethanes', 'Water'] | 19,080,927 | [['Z01.542.846'], ['D02.455.526.913'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
The hemodynamic effects of intravenous ranitidine in intensive care unit patients: a double-blind prospective study. | The hemodynamic effects of intravenous ranitidine were studied in a prospective double-blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found... | ['Adult', 'Aged', 'Aged, 80 and over', 'Critical Care', 'Double-Blind Method', 'Female', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Postoperative Period', 'Ranitidine'] | 3,243,926 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.190', 'N02.421.585.190'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['D03.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bacterial translocation after mesenteric ligation in dogs. | These experiments were designed to determine the relationship between translocation of Escherichia coli and viability of ischemic small bowel. Twenty beagles were gavaged with 14C-labeled E. coli at two time intervals (3 and 24 h) prior to ligation of the blood supply to a 40-cm segment of ileum. Mesenteric lymph node ... | ['Animals', 'Bacterial Infections', 'Blood Gas Analysis', 'Carbon Radioisotopes', 'Colitis, Ischemic', 'Dogs', 'Escherichia coli', 'Gastrointestinal Motility', 'Hemodynamics', 'Intestine, Small', 'Ligation', 'Mesentery', 'Regional Blood Flow', 'Sepsis', 'Survival Analysis'] | 8,887,067 | [['B01.050'], ['C01.150.252'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C06.405.205.265.115', 'C06.405.469.158.188.115', 'C14.907.286'], ['B01.050.150.900.649.313.750.250.216.200'], ['B03.440.450.425.325.300', 'B03.660.25... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pleomorphic adenoma originated from the inferior nasal turbinate. | Although pleomorphic adenoma is the most common benign neoplasm of the salivary glands, it has also been reported to be present in the neck, ear, mediastinum, external nose and nasal cavity. Intranasal localization of this lesion is very rare and mainly originates from the nasal septum. From wherever the lesion origina... | ['Adenoma, Pleomorphic', 'Adult', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Nose Neoplasms', 'Otorhinolaryngologic Surgical Procedures', 'Turbinates'] | 14,656,569 | [['C04.557.435.090', 'C04.557.470.035.155'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C04.588.149.721.600', 'C04.588.443.665.650', 'C05.116.231.754.600', 'C08.460.669', 'C08.785.600', 'C09.603.669', 'C09.647.685'], ['E04.580'], ['A02.835.232.781.324.948', 'A04.531.898... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Associations between primary care practice type and patient-reported access. | BACKGROUND: We recently defined a global typology of primary care (PC) in Switzerland using a mixed inductive/deductive approach to construct latent, composite variables that summarize variance between practices. Now we explore associations between the primary variable that describes the comprehensiveness of services a... | ['Adult', 'Appointments and Schedules', 'Cross-Sectional Studies', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Primary Health Care', 'Surveys and Questionnaires', 'Switzerland', 'Time Factors'] | 30,326,886 | [['M01.060.116'], ['N04.452.095'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['N04.590.233.727'], ... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. | The metabolic programs of functionally distinct T cell subsets are tailored to their immunologic activities. While quiescent T cells use oxidative phosphorylation (OXPHOS) for energy production, and effector T cells (Teffs) rely on glycolysis for proliferation, the distinct metabolic features of regulatory T cells (Tre... | ['AMP-Activated Protein Kinases', 'Animals', 'Autoimmune Diseases', 'CD4 Lymphocyte Count', 'Cell Proliferation', 'Cell Survival', 'Energy Metabolism', 'Gene Expression Regulation', 'Homeostasis', 'Immune Tolerance', 'Lymph Nodes', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mitochondria', 'Protein-Serine-... | 29,109,251 | [['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['B01.050'], ['C20.111'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic factors of local recurrence and survival after curative rectal cancer surgery: a single institution experience. | The aim of our study is to evaluate the importance of prognostic factors, both tumor-related and therapy related, and their impact on local recurrence rate of rectal carcinoma. It is also important to evaluate impact of chemoradiotherapy (CRT) on local recurrence rate and survival. We used the data of 514 patients with... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Neoplasm, Residual', 'Prognosis', 'Rectal Neoplasms', 'Risk Factors', 'Young Adult'] | 23,390,833 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['E01.789.625'], ['C04.697.700', 'C23.550.727.700'], ['E01.789'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790'... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. | PAMAM Starburst dendrimers are spherical macromolecules composed of repeating polyamidoamino units. They can be produced in successive "generations," each with a defined size, molecular weight, and number of terminal amino groups. Because of these well-defined characteristics, PAMAMs are finding utility in a variety of... | ['Animals', 'Biocompatible Materials', 'Cells, Cultured', 'Cricetinae', 'Cricetulus', 'Dendrimers', 'Male', 'Materials Testing', 'Mice', 'Polyamines', 'Tissue Distribution'] | 8,788,106 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A11.251'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['E05.570'], ['B01.050.150.900.649.313.992.635.505.500'], ['D02.092.782'], ['G03.787.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Gemcitabine in combination with vinorelbine for heavily pretreated advanced breast cancer. | PURPOSE: To evaluate the activity and toxicity of gemcitabine and vinorelbine in patients with metastatic breast cancer (MBC), previously treated with anthracyclines alone or with taxanes.PATIENTS AND METHODS: A total of 86 pretreated patients with MBC (median age 62 years), entered the study. Thirty-six patients had b... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Deoxycytidine', 'Drug Administration Schedule', 'Female', 'Humans', 'Middle Aged', 'Vinblastine', 'Vinorelbine'] | 16,739,318 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.132.436.681.827.650', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Feasibility and safety of paclitaxel-eluting balloon for the treatment of de novo coronary lesions]. | Objective: To evaluate the safety and feasibility of treating de novo coronary lesions with paclitaxel-eluting balloon. Methods: This is a retrospective study, which enrolled 76 patients with 80 de novo coronary lesions treated with paclitaxel-eluting balloons(<30% residual stenosis and there was no blood flow limited ... | ['Acute Coronary Syndrome', 'Aged', 'Angioplasty, Balloon, Coronary', 'Coronary Angiography', 'Diabetes Mellitus, Type 2', 'Drug-Eluting Stents', 'Female', 'Humans', 'Male', 'Middle Aged', 'Paclitaxel', 'Prospective Studies', 'Retrospective Studies', 'Stents', 'Time Factors', 'Treatment Outcome', 'Tubulin Modulators'] | 29,374,936 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Nasolabial flap reconstruction of the columella]. | We report three cases of squamous cell carcinoma of the columella invading the sub-partitions. Wide resection raised the problem of several nasal esthetics sub-units. A chronological review of columella reconstruction procedures explained why the nasolabial fragment rarely used for partial rhinopoiesis, was appropriate... | ['Carcinoma, Squamous Cell', 'Humans', 'Male', 'Middle Aged', 'Nasal Septum', 'Nose Deformities, Acquired', 'Nose Neoplasms', 'Rhinoplasty', 'Surgical Flaps'] | 15,211,216 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A04.531.591'], ['C08.460.619', 'C09.603.619'], ['C04.588.149.721.600', 'C04.588.443.665.650', 'C05.116.231.754.600', 'C08.460.669', 'C08.785.600', 'C09.603.669', 'C09.647.685'], ['E02.218.755', 'E04.... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Renal insufficiency: comparison of ultrasound and laboratory profiles in HIV-negative and HIV-positive patients]. | The purpose of this study was to examine whether HIV infection affects either the echographic or laboratory profiles of renal insufficiency. This prospective study compared both echographic (kidney size, Hricak's cortical echogenicity grades) and laboratory (blood urea and creatine) profiles in two groups of patients w... | ['Adolescent', 'Adult', 'Aged', 'Creatine', 'Female', 'HIV Seronegativity', 'HIV Seropositivity', 'Humans', 'Kidney', 'Kidney Cortex', 'Male', 'Middle Aged', 'Prospective Studies', 'Renal Insufficiency', 'Ultrasonography', 'Urea'] | 16,207,581 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.078.370.280', 'D12.125.373'], ['G12.400'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Decontamination of gum arabic with gamma-rays or electron beams and effects of these treatments on the material. | Samples of gum arabic were irradiated to 2.5, 5.0 and 10.0 kGy with gamma-rays and electrons for a comparison of the relative effectiveness of these two treatments and for investigation of the effects of these doses of radiation on the material. The initial raw samples were contaminated with various strains of bacteria... | ['Bacteria', 'Colony Count, Microbial', 'Decontamination', 'Dose-Response Relationship, Drug', 'Electrons', 'Food Contamination', 'Gamma Rays', 'Gum Arabic', 'Microbial Viability', 'Radiation Dosage', 'Sterilization'] | 16,904,901 | [['B03'], ['E01.370.225.875.220', 'E05.200.875.220'], ['N06.850.780.325'], ['G07.690.773.875', 'G07.690.936.500'], ['G01.249.335', 'G01.358.500.750'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['D05.750.078.739.500', 'D09.69... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Translation, cultural adaptation, initial reliability, and validation of the Kidney Disease and Quality of Life-Short Form (KDQOL-SF 1.3) in Turkey. | Health-related quality of life (HRQoL) is an important factor that can interfere with treatment outcomes. The aim of the present study was cultural adaptation, validation, and translation of the Kidney Disease Quality of Life-Short Form (KDQoL-SF 1.3) questionnaire into Turkish for the Turkish population. The KDQOL-SF ... | ['Attitude to Health', 'Emotions', 'Fatigue', 'Health Status', 'Humans', 'Kidney Diseases', 'Pain', 'Quality of Life', 'Reproducibility of Results', 'Social Behavior', 'Surveys and Questionnaires', 'Turkey'] | 17,275,473 | [['F01.100.150', 'N05.300.150'], ['F01.470'], ['C23.888.369'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'],... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Annealing-free, flexible silver nanowire-polymer composite electrodes via a continuous two-step spray-coating method. | For the realization of high-efficiency flexible optoelectronic devices, transparent electrodes should be fabricated through a low-temperature process and have the crucial feature of low surface roughness. In this paper, we demonstrated a two-step spray-coating method for producing large-scale, smooth and flexible silve... | ['Adsorption', 'Electric Conductivity', 'Electrodes', 'Equipment Design', 'Equipment Failure Analysis', 'Hardness', 'Hot Temperature', 'Materials Testing', 'Metal Nanoparticles', 'Particle Size', 'Polystyrenes', 'Silver', 'Surface Properties', 'Thiophenes'] | 23,241,687 | [['G01.030', 'G02.020'], ['G01.358.500.249.277'], ['E07.305.250'], ['E05.320'], ['E05.325.192'], ['G01.374.647'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.570'], ['J01.637.512.600.500'], ['G02.712'], ['D02.455.426.559.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Orbital intramuscular hemangioma enlarging during pregnancy. | A 31-year-old pregnant woman presented with subacute painful proptosis due to an orbital apex mass arising from the right medial rectus muscle. The patient developed compressive optic neuropathy refractory to systemic prednisone and underwent orbitotomy with posterior orbital decompression through a transcaruncular app... | ['Adult', 'Female', 'Hemangioma', 'Humans', 'Magnetic Resonance Imaging', 'Muscle Neoplasms', 'Oculomotor Muscles', 'Orbital Neoplasms', 'Pregnancy', 'Pregnancy Complications, Neoplastic', 'Tomography, X-Ray Computed'] | 19,935,259 | [['M01.060.116'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C04.588.839.500', 'C05.651.494'], ['A02.633.567.700'], ['C04.588.149.721.656', 'C04.588.364.659', 'C05.116.231.754.659', 'C11.319.457', 'C11.675.659'], ['G08.686.784.769'], ['C04.850', 'C13.703.720'], ['E0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. | Missense variants located to the "molecular brake" in the tyrosine kinase hinge region of platelet-derived growth factor receptor-â, encoded by PFGFRB, can cause Penttinen-type (Val665Ala) and Penttinen-like (Asn666His) premature ageing syndromes, as well as infantile myofibromatosis (Asn666Lys and Pro660Thr). We have ... | ['Acro-Osteolysis', 'Adult', 'Aging', 'Apoptosis', 'Cockayne Syndrome', 'Female', 'Genetic Predisposition to Disease', 'HeLa Cells', 'Humans', 'Imatinib Mesylate', 'Limb Deformities, Congenital', 'Male', 'Mitogen-Activated Protein Kinase 3', 'Mutation, Missense', 'Myofibromatosis', 'Phenotype', 'Phosphorylation', 'Prog... | 30,573,803 | [['C05.116.099.052', 'C05.116.264.579.052'], ['M01.060.116'], ['G07.345.124'], ['G04.146.954.035'], ['C05.116.099.343.250', 'C10.574.500.362', 'C16.131.077.250', 'C16.320.240.562', 'C16.320.400.200', 'C18.452.284.250'], ['C23.550.291.687.500', 'G05.380.355'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Drastic acceleration of fibrillation of insulin by transient cavitation bubble. | Amyloid-fibril formation of proteins can be accelerated by ultrasonic irradiation to the peptide solutions. Although this phenomenon contributes to understanding pathogenic behavior of amyloidosis, its physical mechanism has not been clarified, because several factors (cavitation, temperature increase, stirring effect,... | ['Insulin', 'Kinetics', 'Protein Multimerization', 'Protein Structure, Secondary', 'Ultrasonic Waves'] | 28,069,203 | [['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G01.374.661', 'G02.111.490'], ['G02.111.694'], ['G02.111.570.820.709.600'], ['G01.750.770.776.891']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Circulating "LncPPARä" From Monocytes as a Novel Biomarker for Coronary Artery Diseases. | To investigate long noncoding RNA NONHSAT112178 (LncPPARä) as a biomarker for coronary artery disease (CAD) in peripheral blood monocyte cells, RT-qPCR was performed to validate the microarray results, receiver operating characteristic curve was applied to study the potential of LncPPARä as a biomarker. Diagnostic mode... | ['Aged', 'Aged, 80 and over', 'Biomarkers', 'Case-Control Studies', 'Coronary Artery Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Monocytes', 'Oligonucleotide Array Sequence Analysis', 'PPAR delta', 'RNA, Long Noncoding', 'ROC Curve', 'Reverse Transcriptase Polymerase Chain Reaction'] | 26,871,769 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A11.118.637.555.652', 'A11.148.580', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prevention of adverse drug events and cost savings associated with PharmD interventions in an academic Level I trauma center: an evidence-based approach. | BACKGROUND: The financial benefit of an established clinical pharmacy service in the trauma intensive care unit has not been well-described. This study was conducted to identify adverse drug events prevented by the clinical pharmacy team and to determine the net cost savings associated with their input on a multidiscip... | ['Academic Medical Centers', 'Cost Savings', 'Drug Costs', 'Drug-Related Side Effects and Adverse Reactions', 'Hospital Costs', 'Humans', 'Pharmacists', 'Pharmacy Service, Hospital', 'Professional Role', 'Retrospective Studies', 'Tennessee', 'Trauma Centers'] | 23,064,610 | [['N02.278.020'], ['N03.219.151.160.200'], ['N03.219.151.400.350', 'N05.300.375.300'], ['C25.100'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.780', 'N02.360.780'], ['N02.278.216.500.968.603', 'N02.421.668.556', 'N04.452.442.452.422.603'... | ['Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Serum Endothelial Cell-Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance. | Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell-specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216)... | ['Aged', 'Biomarkers', 'C-Reactive Protein', 'Case-Control Studies', 'Coronary Angiography', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Neoplasm Proteins', 'Pilot Projects', 'Proteoglycans', 'Severity of Illness Index'] | 27,225,701 | [['M01.060.116.100'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['E05.318.372.500.875', 'N05.715.360.330.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photochemical assembly of gold nanoparticles utilizing the photodimerization of thymine. | Irradiation of UV light to the solution of gold nanoparticles modified with thymine units resulted in the formation of aggregates comprising chemical cross-linking gold nanoparticles through the photodimerization of the thymine units. Transmission electron microscopy and UV-visible absorption measurement showed the agg... | ['Dimerization', 'Gold', 'Microscopy, Electron, Transmission', 'Nanostructures', 'Thymine', 'Ultraviolet Rays'] | 15,801,470 | [['G02.206', 'G03.230'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['J01.637.512'], ['D03.383.742.698.875.899'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600',... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Draft genome sequence of a CTX-M-15-producing Klebsiella pneumoniae sequence type 340 (clonal complex 258) isolate from a food-producing animal. | Klebsiella pneumoniae carrying blaCTX-M-15 have been widely disseminated in hospital settings. In this regard, most clinically important strains belong to clonal complex 28 (CC258), which includes sequence type 340 (ST340). In this study, we present the draft genome sequence of a CTX-M-15-producing ST340 K. pneumoniae ... | ['Animals', 'Brazil', 'Genome, Bacterial', 'Klebsiella Infections', 'Klebsiella pneumoniae', 'Swine', 'Swine Diseases', 'beta-Lactamases'] | 27,664,870 | [['B01.050'], ['Z01.107.757.176'], ['G05.360.340.358.207'], ['C01.150.252.400.310.503'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['D08.811.277.087.180']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Effects of continuous intra-articular infusion of gentamicin on synovial membrane and articular cartilage in the tarsocrural joint of horses. | OBJECTIVE: To determine the effects of a continuous intra-articular infusion of gentamicin on the synovial membrane and articular cartilage in the tarsocrural joint of horses.ANIMALS: 6 healthy adult horses.PROCEDURE: A balloon infusion system attached to a catheter placed in the plantarolateral pouch of both tarsocrur... | ['Animals', 'Anti-Bacterial Agents', 'Cartilage, Articular', 'Female', 'Gentamicins', 'Glycosaminoglycans', 'Histocytochemistry', 'Horses', 'Male', 'Phenazines', 'Synovial Membrane', 'Tarsus, Animal'] | 12,013,469 | [['B01.050'], ['D27.505.954.122.085'], ['A02.165.407.150', 'A02.835.583.192'], ['D09.408.051.374'], ['D09.698.373'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.984.235.472'], ['D03.633.300.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioconcentration and trophic transfer of polychlorinated biphenyls and polychlorinated dibenzo-p-dioxins and dibenzofurans in aquatic animals from an e-waste dismantling area in East China. | Eight aquatic biota species were collected from an e-waste dismantling area in East China to investigate bioconcentration and trophic transfer of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). The mean concentrations of PCBs varied widely from 6.01... | ['Animals', 'Aquatic Organisms', 'Benzofurans', 'China', 'Dibenzofurans, Polychlorinated', 'Electronic Waste', 'Environmental Monitoring', 'Food Chain', 'Polychlorinated Biphenyls', 'Polychlorinated Dibenzodioxins', 'Water Pollutants, Chemical'] | 25,689,167 | [['B01.050'], ['B05.080', 'G16.500.275.725.500.650.075'], ['D03.633.100.127'], ['Z01.252.474.164'], ['D02.309.250', 'D03.633.300.258.500'], ['N06.850.460.710.189'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.157.250', 'N06.230.124.250'], ['D02.309.750', 'D02.455.426.559.389.185.698', 'D02.455.526.439.773... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Cognitive processing of cluster headache patients: evidence from event-related potentials. | BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central region... | ['Adult', 'Cerebral Cortex', 'Cluster Headache', 'Cognition Disorders', 'Event-Related Potentials, P300', 'Evoked Potentials', 'Female', 'Functional Laterality', 'Functional Neuroimaging', 'Humans', 'Male'] | 25,277,954 | [['M01.060.116'], ['A08.186.211.200.885.287.500'], ['C10.228.140.546.399.937.500'], ['F03.615.250'], ['G07.265.216.500.350', 'G11.561.200.500.350'], ['G07.265.216.500', 'G11.561.200.500'], ['F02.830.297.425', 'G11.561.225.425'], ['E01.370.350.578.875', 'E01.370.376.537.625', 'E05.629.875'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Survey of HBag hepatitis infection in a semi-closed community. | The presentation of one individual with HBAg-positive hepatitis in a semi-closed community led to the testing of 262 intellectually-handicapped persons and staff-members and to the detection of 12 others who were HBAg-positive. Only the presenting case and one other became unwell with hepatitis. Three other HBAg-positi... | ['Carrier State', 'Down Syndrome', 'Female', 'Health Facilities', 'Hepatitis B', 'Hepatitis B Antigens', 'Humans', 'Intellectual Disability', 'Male', 'New Zealand'] | 128,713 | [['N06.850.520.169'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['N02.278'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', ... | ['Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
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