Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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"Pap" smear and the risk of cervical neoplasia: quantitative estimates from a case-control study. | The relation between Papanicolau ("Pap") smear and the risk of cervical neoplasia was evaluated in a case-control study in which 145 women with cervical intra-epithelial neoplasia (CIN) were compared with 145 age-matched outpatient controls, and 191 cases of invasive cervical cancer were compared with 191 control subje... | ['Adult', 'Aged', 'Female', 'Humans', 'Italy', 'Middle Aged', 'Papanicolaou Test', 'Risk', 'Sexual Behavior', 'Smoking', 'Time Factors', 'Uterine Cervical Neoplasms', 'Vaginal Smears'] | 6,148,523 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['E01.370.225.500.384.100.422', 'E01.370.225.998.054.422', 'E04.074.422', 'E05.200.500.384.100.422', 'E05.200.998.054.422', 'E05.242.384.100.422'], ['E05.318.740.600.800', 'G17.680.750', 'N05.71... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Welfare assessment in broiler farms: transect walks versus individual scoring. | Current scientific approaches to welfare assessment in broilers are based on individual sampling that can be time consuming under field conditions. On the other hand, farmers conduct routine checks based on walks through the house to screen birds' health condition. We adapted the walks through following line transect m... | ['Animal Husbandry', 'Animal Welfare', 'Animals', 'Behavior, Animal', 'Chickens', 'Observer Variation', 'Poultry Diseases', 'Prevalence', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spain'] | 24,046,404 | [['J01.040.090'], ['I01.880.604.100'], ['B01.050'], ['F01.145.113'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['C22.131.728'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.8... | ['Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Gluconobacter as well as Asaia species, newly emerging opportunistic human pathogens among acetic acid bacteria. | Acetic acid bacteria (AAB) are broadly used in industrial food processing. Among them, members of the genera Asaia, Acetobacter, and Granulibacter were recently reported to be human opportunistic pathogens. We isolated AAB from clinical samples from three patients and describe here the clinical and bacteriological feat... | ['Acetobacteraceae', 'Anti-Bacterial Agents', 'Cluster Analysis', 'DNA Fingerprinting', 'DNA, Bacterial', 'DNA, Ribosomal', 'Electrophoresis, Gel, Pulsed-Field', 'Genotype', 'Gram-Negative Bacterial Infections', 'Humans', 'Microbial Sensitivity Tests', 'Molecular Sequence Data', 'Opportunistic Infections', 'Phylogeny',... | 20,826,638 | [['B03.440.400.425.100', 'B03.660.050.755.050'], ['D27.505.954.122.085'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.212'], ['D13.444.308.475'], ['E05.196.401.220', 'E05.301.300.220'], ['G05.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Safety, clinical outcome, and fracture rate of femoropopliteal stenting using a 4F compatible delivery system. | OBJECTIVE: To determine the safety, clinical outcome, and fracture rate of femoropopliteal interventions using 4F stents.METHODS: Between January 2010 and December 2011, 112 symptomatic patients were treated by stent implantation. Ten patients were lost to follow up; therefore, 102 patients (62 men; mean age 66.4 ± 10.... | ['Adult', 'Aged', 'Aged, 80 and over', 'Amputation', 'Ankle Brachial Index', 'Constriction, Pathologic', 'Critical Illness', 'Endovascular Procedures', 'Female', 'Femoral Artery', 'Humans', 'Intermittent Claudication', 'Ischemia', 'Limb Salvage', 'Male', 'Middle Aged', 'Peripheral Arterial Disease', 'Popliteal Artery',... | 25,579,877 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.080'], ['E01.370.370.140.049'], ['C23.300.287'], ['C23.550.291.625'], ['E04.100.814.529', 'E04.502.382'], ['A07.015.114.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.513'], ['E04.100.814... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changes of proton transportation across the inner mitochondrial membrane and H(+)-ATPase in endotoxic shock rats. | OBJECTIVE: To investigate the changes of proton transportation across the inner mitochondrial membrane (IMM) and H(+)-ATPase of hepatocytes in endotoxic shock rats.METHODS: Endotoxin from E. Coil of 5.0 mg/kg or saline of 1 ml/kg was injected into the femoral vein. The rats were sacrificed pre-injection and 1, 3, 5, 8 ... | ['Animals', 'Microscopy, Electron', 'Mitochondria, Liver', 'Proton-Translocating ATPases', 'Rats', 'Rats, Wistar', 'Shock, Septic'] | 14,514,367 | [['B01.050'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['D08.811.277.040.025.325', 'D08.811.913.696.650.150.500', 'D12.776.157.530.450.250.875.500', 'D12.776.543.585.450.250.875.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives. | The methylene chloride extract of Miconia ligustroides (DC.) Naudin (Melastomataceae), the isolated compounds ursolic and oleanolic acids and a mixture of these acids, and ursolic acid derivatives were evaluated against the following microorganisms: Bacillus cereus (ATCC 14579), Vibrio cholerae (ATCC 9458), Salmonella ... | ['Anti-Bacterial Agents', 'Brazil', 'Drug Discovery', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Magnetic Resonance Spectroscopy', 'Medicine, Traditional', 'Melastomataceae', 'Methylene Chloride', 'Microbial Sensitivity Tests', 'Molecular Structure', 'Oleanolic Acid', 'Phytotherapy', 'Plant Components, Aerial... | 20,645,834 | [['D27.505.954.122.085'], ['Z01.107.757.176'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['B03.440'], ['B03.510'], ['E05.196.867.519'], ['E02.190.488', 'I01.076.201.450.654'], ['B01.650.940.800.575.912.250.707'], ['D02.455.526.439.642'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G02.... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
The Fate of Polyol-Made ZnO and CdS Nanoparticles in Seine River Water (Paris, France). | This study aims to characterize nanoparticles with different compositions and structures as well as seeing their evolutions over time in a natural environment such as Seine river water (Paris, France). Face centered cubic (fcc) and hexagonal (hcp) CdS as well as hexagonal (hcp) ZnO nanoparticles were synthesized by the... | ['Cadmium Compounds', 'Hydrogen-Ion Concentration', 'Metal Nanoparticles', 'Paris', 'Polymers', 'Rivers', 'Scattering, Small Angle', 'Sulfides', 'X-Ray Diffraction', 'Zinc Oxide'] | 26,505,021 | [['D01.142'], ['G02.300'], ['J01.637.512.600.500'], ['Z01.433.800', 'Z01.542.286.588'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['E05.196.822.830', 'G01.867.755'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02.886.520'], ['E05.196.309.742', 'E05.196.822.95... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. | Heterotrimeric G proteins act during signal transduction in response to extracellular ligands. They are also required for spindle orientation and cell polarity during asymmetric cell division. We show here that, in Drosophila, both functions require the Galpha interaction partner Ric-8. Drosophila Ric-8 is a cytoplasmi... | ['Animals', 'Animals, Genetically Modified', 'Cell Division', 'Cell Membrane', 'Cell Polarity', 'Drosophila', 'Drosophila Proteins', 'GTP-Binding Protein alpha Subunits, Gi-Go', 'GTP-Binding Protein beta Subunits', 'Guanine Nucleotide Exchange Factors', 'Heterotrimeric GTP-Binding Proteins', 'Neurons', 'Transforming Gr... | 16,228,011 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.149'], ['G04.250'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['D08.811.277.040.330.300.200.100.200', 'D12.644.360.360.100.200', 'D12.776.157.325.332.100.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal ultrasound diagnosis of fetal scoliosis with termination of the pregnancy: case report. | Gross scoliosis of the fetal thoracic spine was diagnosed at 18 weeks gestation. The pregnancy was terminated and the fetus found to have webbing of the neck and an imperforate anus in addition to vertebral defects. | ['Abortion, Induced', 'Adult', 'Female', 'Fetal Diseases', 'Humans', 'Pregnancy', 'Prenatal Diagnosis', 'Scoliosis', 'Ultrasonography'] | 3,321,026 | [['E04.520.050'], ['M01.060.116'], ['C13.703.277', 'C16.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E01.370.378.630'], ['C05.116.900.800.875'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. | In cirrhotic livers, increased resistance to portal flow, in part due to an exaggerated response to vasoconstrictors, is the primary factor in the pathophysiology of portal hypertension. Our aim was to evaluate the response of the intrahepatic circulation of cirrhotic rat livers to the alpha(1)-adrenergic vasoconstrict... | ['6-Ketoprostaglandin F1 alpha', 'Adrenergic alpha-Agonists', 'Animals', 'Arachidonic Acid', 'Blood Pressure', 'Carbon Tetrachloride', 'Cyclooxygenase 1', 'Cyclooxygenase 2', 'Cyclooxygenase 2 Inhibitors', 'Cyclooxygenase Inhibitors', 'Dinoprost', 'Isoenzymes', 'Liver Circulation', 'Liver Cirrhosis', 'Male', 'Membrane ... | 12,500,202 | [['D10.251.355.255.550.400.350', 'D10.251.355.325.450', 'D23.469.050.175.725.400.350'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D02.455.526.439.150'], ['D08.811.600.720.500'], ['D08... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis is initiated by N(2)-hydroxylation, mediated by several cytochromes P450, including CYP1A1. However, the role of CYP1A1 in PhIP metabolic activation in vivo is unclear. In this study, Cyp1a1-null and wild-type (WT) mice were used to investigate the p... | ['Animals', 'Carcinogens', 'Cytochrome P-450 CYP1A1', 'Enzyme Activation', 'Female', 'Imidazoles', 'Lung', 'Mice', 'Mice, Knockout', 'Tissue Distribution'] | 17,052,995 | [['B01.050'], ['D27.888.569.100'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453.100.500'], ['G02.111.263', 'G03.328'], ['D03.383.129.308'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myel... | PURPOSE: To examine the efficacy of prolonged maintenance chemotherapy versus intensified consolidation therapy for patients with acute myeloid leukemia (AML).MATERIALS AND METHODS: Eight hundred thirty-two patients (median age, 54 years; range, 16 to 82 years) with de novo AML were randomly assigned to receive 6-thiog... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Cytarabine', 'Daunorubicin', 'Female', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Mitoxantrone', 'Prognosis', 'Proportional Hazards Models', 'Survival Analysis', 'Thioguanine'] | 14,673,036 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.059.200'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changes in lymphocyte and macrophage subsets due to morphine and ethanol treatment during a retrovirus infection causing murine AIDS. | Infection by LP-BM5 murine leukemia virus (MuLV) suppressed significantly the percentage of peripheral blood cells showing surface markers for macrophages, lymphocytes and activated lymphoid cells. Chronic administration of a 7% (36% calories) ethanol diet or injection of 1.9 mg/mouse/day of morphine for a 7 day period... | ['Acquired Immunodeficiency Syndrome', 'Animals', 'Disease Models, Animal', 'Ethanol', 'Female', 'Leukemia Virus, Murine', 'Leukemia, Experimental', 'Leukocyte Count', 'Lymphocytes', 'Macrophage Activation', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Morphine', 'T-Lymphocytes, Cytotoxic', 'T-Lymphocytes, Helper-Indu... | 2,841,547 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.033.375'], ['B04.613.807.375.525', 'B04.820.650.375.525'], ['C04.557.337.372', 'C04.61... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. | The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase required for the initiation of mitosis, whereas its inactivation is necessary for mitotic exit. Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for mitotic progression of human cells. Nek6 is phosphorylated and... | ['Anaphase', 'Apoptosis', 'Cell Cycle', 'Cell Line', 'Cell Separation', 'Centrosome', 'Flow Cytometry', 'Genetic Vectors', 'HeLa Cells', 'Humans', 'Metaphase', 'Microscopy', 'Mitosis', 'NIMA-Related Kinases', 'Peptides', 'Phosphorylation', 'Plasmids', 'Precipitin Tests', 'Protein-Serine-Threonine Kinases', 'RNA Interfe... | 14,563,848 | [['G04.144.220.220.687.222', 'G04.144.220.220.781.050', 'G05.113.220.687.250', 'G05.113.220.781.050'], ['G04.146.954.035'], ['G04.144'], ['A11.251.210'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.284.430.214.190.750.585.160', 'A11.284.430.214.190.750.820.500.500'], ['E01.370.225.500.363.342', 'E0... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. | BACKGROUND: Fumaric acid esters (FAE) have been proven to be effective for the systemic treatment of psoriasis and multiple sclerosis, Th1 cell-mediated chronic inflammatory diseases, but their effect on autoimmune myocarditis has not yet been addressed. We investigated the effect of dimethyl fumarate (DMF) on myosin-i... | ['Animals', 'Autoimmune Diseases', 'Dimethyl Fumarate', 'Disease Models, Animal', 'Fumarates', 'Immunosuppressive Agents', 'Interleukin-10', 'Lymphocytes', 'Male', 'Myocarditis', 'Myocardium', 'Myosins', 'Rats', 'Tumor Necrosis Factor-alpha'] | 18,760,191 | [['B01.050'], ['C20.111'], ['D02.241.081.337.302.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.241.081.337.302'], ['D27.505.696.477.656'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['C14.280.238... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conformational transition paths harbor structures useful for aiding drug discovery and understanding enzymatic mechanisms in protein kinases. | This short article examines the usefulness of fast simulations of conformational transition paths in elucidating enzymatic mechanisms and guiding drug discovery for protein kinases. It applies the transition path method in the MOIL software package to simulate the paths of conformational transitions between six pairs o... | ['Biocatalysis', 'Drug Discovery', 'Molecular Dynamics Simulation', 'Molecular Structure', 'Protein Kinase Inhibitors', 'Protein Kinases', 'Software'] | 26,032,746 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G02.111.570', 'G02.466'], ['D27.505.519.389.755'], ['D08.811.913.696.620.682'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
HDAC2 attenuates airway inflammation by suppressing IL-17A production in HDM-challenged mice. | Histone deacetylase (HDAC)2 is expressed in airway epithelium and plays a pivotal role in inflammatory cells. However, the role of HDAC2 in allergic airway inflammation remains poorly understood. In the present study, we determined the role of HDAC2 in airway inflammation using in vivo models of house dust mite (HDM)-i... | ['Animals', 'Asthma', 'Disease Models, Animal', 'Female', 'Histone Deacetylase 2', 'Interleukin-17', 'Male', 'Mice', 'Mice, Knockout', 'Pyroglyphidae', 'Th2 Cells'] | 30,407,865 | [['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D08.811.277.087.520.500.200', 'D08.811.277.087.520.750.200', 'D08.811.600.620.200', 'D08.811.600.795.200'], ['D12.644.276.374.465.517', 'D12.776.467.374.465.517', 'D23.529.374.465.517... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice. | OBJECTIVE: Activation of liver x receptor (LXR) raises plasma HDL-cholesterol (HDL-C) in mice. Interestingly, the LXR agonist GW3965 fails to raise plasma HDL-C in mice lacking intestinal ABCA1, indicating that intestinal ABCA1 plays a predominant role in GW3965-mediated HDL production. How this is coupled to intestina... | ['ATP-Binding Cassette Transporters', 'Analysis of Variance', 'Animals', 'Benzoates', 'Benzylamines', 'Blood Chemical Analysis', 'Cholesterol, HDL', 'DNA-Binding Proteins', 'Disease Models, Animal', 'Injections, Intraperitoneal', 'Liver X Receptors', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Niemann-Pick Disease, Type C',... | 18,187,667 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D02.241.223.100', 'D02.455.426.559.389.127'], ['D02.092.200', 'D02.455.426.559.389.140.210'], ['E01.370.225.124.100', 'E05.200.124.100'], ['D04... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
High-resolution in vivo diffusion imaging of the human brain with generalized slice dithered enhanced resolution: Simultaneous multislice (gSlider-SMS). | PURPOSE: To develop an efficient acquisition for high-resolution diffusion imaging and allow in vivo whole-brain acquisitions at 600- to 700-ìm isotropic resolution.METHODS: We combine blipped-controlled aliasing in parallel imaging simultaneous multislice (SMS) with a novel slab radiofrequency (RF) encoding gSlider (g... | ['Anisotropy', 'Anthropometry', 'Artifacts', 'Brain', 'Brain Mapping', 'Cerebral Cortex', 'Diffusion Tensor Imaging', 'Fourier Analysis', 'Gray Matter', 'Head', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Models, Statistical', 'Motion', 'Phantoms, Imaging', 'Radio Waves', 'Sensitivit... | 28,261,904 | [['G01.590.040', 'G02.050'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E05.047'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['E0... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Young children, but not chimpanzees, are averse to disadvantageous and advantageous inequities. | The age at which young children show an aversion to inequitable resource distributions, especially those favoring themselves, is unclear. It is also unclear whether great apes, as humans' nearest evolutionary relatives, have an aversion to inequitable resource distributions at all. Using a common methodology across spe... | ['Affect', 'Animals', 'Biological Evolution', 'Child', 'Child Behavior', 'Child, Preschool', 'Cooperative Behavior', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Pan troglodytes', 'Resource Allocation', 'Reward', 'Social Behavior'] | 27,918,977 | [['F01.470.047'], ['B01.050'], ['G05.045', 'G16.075'], ['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['F01.145.813.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['B01.050.150.900.649.313.988.400.112.400.620'], ['I01.261.750'], ['F02.463.425.770.836'], ['F01.145.813']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases. | In order for boron neutron capture therapy (BNCT) to be eligible for application in lung tumour disease, three fundamental criteria must be fulfilled: there must be selective uptake of boron in the tumour cells with respect to surrounding healthy tissue, biological effectiveness of the radiation therapy and minimal dam... | ['Animals', 'Boron Compounds', 'Boron Neutron Capture Therapy', 'Cell Line, Tumor', 'Cell Survival', 'Colonic Neoplasms', 'Disease Models, Animal', 'In Vitro Techniques', 'Lung Neoplasms', 'Phenylalanine', 'Radiation Tolerance', 'Radiation-Sensitizing Agents', 'Rats'] | 19,394,841 | [['B01.050'], ['D01.132', 'D02.203'], ['E02.815.722.500.100'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.481'], ['C... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization and Use of a Fiber Optic Sensor Based on PAH/SiO2 | OBJECTIVE: To develop a compact probe that can be used to monitor humidity in ventilator care equipment. A mesoporous film of alternate layers of Poly(allylamine hydrochloride) (PAH) and silica (SiO2) nanoparticles (bilayers), deposited onto an optical fibre was used. The sensing film behaves as a Fabry-Perot cavity of... | ['Equipment Design', 'Equipment Failure Analysis', 'Fiber Optic Technology', 'Humidity', 'Interferometry', 'Membranes, Artificial', 'Nanoconjugates', 'Optical Fibers', 'Polyamines', 'Refractometry', 'Reproducibility of Results', 'Respiration, Artificial', 'Sensitivity and Specificity', 'Silicon Dioxide', 'Transducers'] | 26,829,771 | [['E05.320'], ['E05.325.192'], ['H01.671.617.249'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['E05.490'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['D26.255.260.600', 'E02.319.300.380.600', 'J01.637.512.600.577'], ['E07.632.750'], ['D02.092.782'], ['E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
L-carnitine in beta thalassemia. | This study was conducted to determine L-carnitine levels in regularly transfused and chelated beta thalassemia patients (n=40; mean age, 17.5+/-5.0 years). Ten age matched controls were also studied. The mean L-carnitine level in thalassemic patients was 23.71+/- 7.3 microM as compared to control 29.26+/-2.37 microM (P... | ['Adolescent', 'Adult', 'Blood Transfusion', 'Carnitine', 'Case-Control Studies', 'Child', 'Diet, Vegetarian', 'Female', 'Ferritins', 'Humans', 'India', 'Male', 'beta-Thalassemia'] | 19,430,074 | [['M01.060.057'], ['M01.060.116'], ['E02.095.135'], ['D02.092.877.883.099'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['E02.642.249.300', 'G07.203.650.240.300'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
15N and 1H NMR study of histidine containing protein (HPr) from Staphylococcus carnosus at high pressure. | The pressure-induced changes in 15N enriched HPr from Staphylococcus carnosus were investigated by two-dimensional (2D) heteronuclear NMR spectroscopy at pressures ranging from atmospheric pressure up to 200 MPa. The NMR experiments allowed the simultaneous observation of the backbone and side-chain amide protons and n... | ['Amides', 'Atmospheric Pressure', 'Bacterial Proteins', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Nitrogen Isotopes', 'Phosphoenolpyruvate Sugar Phosphotransferase System', 'Protein Conformation', 'Protons', 'Staphylococcus'] | 10,794,411 | [['D02.065'], ['G16.500.750.274', 'N06.230.300.100.185'], ['D12.776.097'], ['E05.196.867.519'], ['E05.599.595'], ['D01.268.604.500', 'D01.362.625.500', 'D01.496.586'], ['D05.500.562.484', 'D08.811.600.700', 'D08.811.913.696.620.650'], ['G02.111.570.820.709'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pulmonary atresia with intact ventricular septum, right-sided aortic arch, and an aorto-pulmonary collateral artery. | Described is a rare association in a patient with the heart in the left chest, namely pulmonary atresia with intact ventricular septum, fistulous coronary arterial connections, a right-sided aortic arch and an aorto-pulmonary collateral artery feeding one lung. The pulmonary arteries were non-confluent, with the right ... | ['Aorta, Thoracic', 'Collateral Circulation', 'Heart Defects, Congenital', 'Heart Septum', 'Humans', 'Infant, Newborn', 'Male', 'Pulmonary Atresia'] | 10,535,834 | [['A07.015.114.056.372'], ['G09.330.100.248'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['A07.541.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C14.240.850.937', 'C14.280.484.640', 'C16.131.240.850.906']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. | Expression of the recombination activating genes, RAG-1 and RAG-2, in lymphocytes, has been shown to depend on second messenger systems. An increase in intracellular cAMP upon stimulation with caffeine increases RAG expression while activation of protein kinase C (PKC) with phorbol myristate acetate (PMA) results in de... | ['Animals', 'B-Lymphocytes', 'Base Sequence', 'Cell Line', 'DNA Nucleotidyltransferases', 'DNA-Binding Proteins', 'Gene Rearrangement, B-Lymphocyte', 'Homeodomain Proteins', 'Marine Toxins', 'Mice', 'Molecular Sequence Data', 'Oxazoles', 'Phosphoprotein Phosphatases', 'Polymerase Chain Reaction', 'Protein Biosynthesis'... | 7,898,493 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D08.811.913.696.445.308'], ['D12.776.260'], ['G05.344.401', 'G12.500.274'], ['D12.776.260.400'], ['D23.946.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nasomaxillary reconstruction in Binder syndrome: bone versus cartilage grafts. A long-term intercenter comparison between Sweden and Mexico. | Maxillonasal dysplasia is characterized by a concave facial profile and a flat nose. The etiology of Binder syndrome is skeletal hypoplasia around the piriform aperture and excavations-fossae prenasales, bilaterally in the nasal floor-which are pathognomonic. There is no real shortage of the soft tissues. In 2 medical ... | ['Adolescent', 'Bone Transplantation', 'Cartilage', 'Cephalometry', 'Female', 'Humans', 'Male', 'Maxilla', 'Maxillofacial Abnormalities', 'Mexico', 'Nasal Septum', 'Nose', 'Retrospective Studies', 'Rhinoplasty', 'Sweden', 'Syndrome', 'Treatment Outcome', 'Young Adult'] | 18,812,845 | [['M01.060.057'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.165', 'A10.165.382'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['C05.660.207.540', 'C07.650.500', 'C16.131.621.207... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Antimicrobial abietane diterpenoids from Plectranthus elegans. | Two novel abietane diterpenoids have been isolated from the aerial material of Plectranthus elegans and identified as 11-hydroxy-12-oxo-7,9(11),13-abietatriene and 7 alpha,11-dihydroxy-12-methoxy-8,11,13-abietatriene. Their structures were determined through rigorous use of spectroscopic methods. Both inhibited spore g... | ['Abietanes', 'Anti-Bacterial Agents', 'Anti-Infective Agents', 'Chromatography, Thin Layer', 'Cladosporium', 'Diterpenes', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Microbial Sensitivity Tests', 'Plants', 'Spectrum Analysis'] | 8,835,454 | [['D02.455.426.559.847.723.040', 'D02.455.849.291.040', 'D04.615.723.040'], ['D27.505.954.122.085'], ['D27.505.954.122'], ['E05.196.181.400.537'], ['B01.300.381.200'], ['D02.455.849.291'], ['B03.440'], ['B03.510'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B01.650'], ['E05.196.867']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reactivity and prevalence of neutralizing antibodies against Japanese strains of bovine viral diarrhea virus subgenotypes. | Bovine viral diarrhea virus (BVDV) field isolates show genetic and antigenic diversity. At least 14 subgenotypes of BVDV-1 and 4 of BVDV-2 have been identified in Artiodactyla worldwide. Of these, 6 subgenotypes of BVDV-1 and 1 of BVDV-2 have been isolated in Japan. Previously, we reported that each subgenotype virus e... | ['Animals', 'Antibodies, Neutralizing', 'Antibodies, Viral', 'Bovine Virus Diarrhea-Mucosal Disease', 'Cattle', 'Cross Reactions', 'Diarrhea Viruses, Bovine Viral', 'Genetic Variation', 'Genotype', 'Japan', 'Phylogeny', 'Prevalence'] | 19,931,181 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C01.925.782.350.675.106', 'C22.196.106'], ['B01.050.150.900.649.313.500.380.271'], ['G12.122.281'], ['B04.820.578.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Quality of intrapartum care by skilled birth attendants in a refugee clinic on the Thai-Myanmar border: a survey using WHO Safe Motherhood Needs Assessment. | BACKGROUND: Increasing the number of women birthing with skilled birth attendants (SBAs) as one of the strategies to reduce maternal mortality and morbidity must be partnered with a minimum standard of care. This manuscript describes the quality of intrapartum care provided by SBAs in Mae La camp, a low resource, protr... | ['Adult', 'Ambulatory Care Facilities', 'Delivery, Obstetric', 'Female', 'Health Care Surveys', 'Humans', 'Infant, Newborn', 'Midwifery', 'Myanmar', 'Needs Assessment', 'Perinatal Care', 'Pregnancy', 'Pregnancy Outcome', 'Professional Competence', 'Quality Improvement', 'Quality of Health Care', 'Refugees', 'Thailand'] | 25,652,646 | [['M01.060.116'], ['N02.278.035'], ['E04.520.252'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['H02.478.676.416'], ['Z01.252.145.570'], ['I02.594', 'N03.349.380.565', 'N05.300.537... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [... | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Antimicrobial susceptibility breakpoints and first-step parC mutations in Streptococcus pneumoniae: redefining fluoroquinolone resistance. | Clinical antimicrobial susceptibility breakpoints are used to predict the clinical outcome of antimicrobial treatment. In contrast, microbiologic breakpoints are used to identify isolates that may be categorized as susceptible when applying clinical breakpoints but harbor resistance mechanisms that result in their redu... | ['Anti-Infective Agents', 'DNA Gyrase', 'DNA Topoisomerase IV', 'Drug Resistance, Multiple, Bacterial', 'Gene Expression Regulation, Bacterial', 'Levofloxacin', 'Microbial Sensitivity Tests', 'Mutation', 'Ofloxacin', 'Streptococcus pneumoniae'] | 12,890,324 | [['D27.505.954.122'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['D08.811.399.403.741.224', 'D12.776.097.256'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['G05.308.300'], ['D03.633.100.810.835.322.500.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.33... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gender and crime victimization modify neighborhood effects on adolescent mental health. | OBJECTIVE: Leverage an experimental study to determine whether gender or recent crime victimization modify the mental health effects of moving to low-poverty neighborhoods.METHODS: The Moving to Opportunity (MTO) study randomized low-income families in public housing to an intervention arm receiving vouchers to subsidi... | ['Adolescent', 'Adolescent Behavior', 'Child', 'Child, Preschool', 'Crime', 'Crime Victims', 'Family', 'Female', 'Humans', 'Male', 'Mental Health', 'Poverty Areas', 'Psychology, Adolescent', 'Public Housing', 'Stress, Psychological'] | 22,908,105 | [['M01.060.057'], ['F01.145.022'], ['M01.060.406'], ['M01.060.406.448'], ['I01.198.240', 'I01.880.735.191'], ['M01.135'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['I01.880.853.996.535.550', 'N01.824.600.550'], ['F04.096.628.065'], ['J03.340.650', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Visual motion speed determines a behavioral switch from forward flight to expansion avoidance in Drosophila. | As an animal translates through the world, its eyes will experience a radiating pattern of optic flow in which there is a focus of expansion directly in front and a focus of contraction behind. For flying fruit flies, recent experiments indicate that flies actively steer away from patterns of expansion. Whereas such a ... | ['Animals', 'Avoidance Learning', 'Behavior, Animal', 'Drosophila melanogaster', 'Female', 'Flight, Animal', 'Motion Perception', 'Orientation', 'Photic Stimulation', 'Time Factors', 'Visual Perception'] | 23,197,097 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['F02.463.593.932.567'], ['F01.058.577', 'F02.830.606'], ['E05.723.729'], ['G01.910.857'], ['F02.463.593.932']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lethal and sublethal effects of cantharidin on the life history traits and population parameters of Helicoverpa armigera (H?bner) (Lepidoptera: Noctuidae). | BACKGROUND: The cotton bollworm, Helicoverpa armigera (H?bner), is a serious and cosmopolitan pest of many economic crops. Its control has not been adequate owing to its resistance to many groups of insecticides. Toxicity of cantharidin on armyworm and diamondback moth has already been reported. However, its toxicity o... | ['Animals', 'Cantharidin', 'Female', 'Insect Control', 'Lepidoptera', 'Life Cycle Stages', 'Male', 'Reproduction'] | 23,423,969 | [['B01.050'], ['D03.633.100.127.125'], ['N06.850.780.200.650.425'], ['B01.050.500.131.617.720.500.500.937'], ['B05.500', 'G07.345.500.550.500'], ['G08.686.784']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Serum concentration of piroxicam and inhibition of platelet aggregation in patients with rheumatoid arthritis and M. Bechterew. | An open trial was conducted in 22 in-patients with classic or definite rheumatoid arthritis (RA) and 17 in-patients with M. Bechterew with the aim to investigate the effect of increasing concentrations of piroxicam in vivo on the platelet aggregation in such patients. In all patients therapy with piroxicam (10 mg/d) wa... | ['Adult', 'Arthritis, Rheumatoid', 'Chromatography, High Pressure Liquid', 'Female', 'Humans', 'Male', 'Middle Aged', 'Piroxicam', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Spondylitis, Ankylosing'] | 7,741,041 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.886.665.500', 'D03.383.855.500'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D27.505.954.502.780'], ['C05.116.900.853.625.800.85... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Acquired amegakaryocytic thrombocytopenia purpura in a Rhesus macaque (Macaca mulatta). | A 10-y-old multiparous rhesus macaque presented for an annual routine physical examination. Clinically, the animal had pale mucous membranes, petechial and ecchymotic hemorrhages in multiple sites, and a laceration at the tail base. Severe pancytopenia was noted on hematologic evaluation. The monkey was seronegative f... | ['Animals', 'Bone Marrow Diseases', 'Macaca mulatta', 'Purpura, Thrombocytopenic'] | 22,776,057 | [['B01.050'], ['C15.378.190'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['C15.378.100.802.687', 'C15.378.140.855.925.750', 'C20.841', 'C23.550.414.950.687', 'C23.888.885.687.687']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-performance liquid chromatographic determination of norfloxacin in human tissues and plasma with fluorescence detection. | A high-performance liquid chromatographic method with fluorimetric detection is described for the quantitative determination of norfloxacin in renal and prostatic tissues and in plasma. It consists of tissue pretreatment, purification by solid-state extraction and separation and quantification by high-performance liqui... | ['Chromatography, High Pressure Liquid', 'Female', 'Humans', 'Indicators and Reagents', 'Kidney', 'Kinetics', 'Male', 'Norfloxacin', 'Prostate', 'Spectrometry, Fluorescence'] | 3,624,391 | [['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['D03.633.100.810.835.322.374'], ['A05.360.444.575', 'A10.336.707'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Circulating Exosomal miR-17 Inhibits the Induction of Regulatory T Cells via Suppressing TGFBR II Expression in Rheumatoid Arthritis. | BACKGROUND/AIMS: A reduced prevalence of circulating regulatory T cells (Tregs)is a hallmark of inflammatory rheumatoid arthritis (RA). However, the underlying mechanisms of alterations of Tregs are unclear.METHODS: The ratio of Tregs in peripheral blood of healthy controls (HCs) and patients with RA was determined by ... | ["3' Untranslated Regions", 'Adult', 'Aged', 'Antagomirs', 'Arthritis, Rheumatoid', 'Case-Control Studies', 'Cell Differentiation', 'Exosomes', 'Female', 'Humans', 'Male', 'MicroRNAs', 'Middle Aged', 'Protein-Serine-Threonine Kinases', 'RNA Interference', 'RNA, Small Interfering', 'Receptor, Transforming Growth Factor-... | 30,384,383 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['M01.060.116'], ['M01.060.116.100'], ['D13.695.578.424.112'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots. | INTRODUCTION: Fibrinolytics such as recombinant tissue plasminogen activator (rt-PA) are used to treat thrombotic disease such as acute myocardial infarction (AMI) and ischemic stroke. Interest in increasing efficacy and reducing side effects has led to the study of adjuncts such as GP IIb-IIIa inhibitors and ultrasoun... | ['Combined Modality Therapy', 'Drug Therapy, Combination', 'Eptifibatide', 'Fibrinolytic Agents', 'Humans', 'In Vitro Techniques', 'Peptides', 'Platelet Aggregation Inhibitors', 'Platelet Glycoprotein GPIIb-IIIa Complex', 'Recombinant Proteins', 'Thrombolytic Therapy', 'Thrombosis', 'Tissue Plasminogen Activator', 'Ult... | 18,619,651 | [['E02.186'], ['E02.319.310'], ['D12.644.641.366'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D12.644'], ['D27.505.954.502.780'], ['D12.776.395.550.625.785', 'D12.776.543.550.625.785', 'D12.776.543.750.705.408.460.700', 'D12.77... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discovering cooperative relationships of chromatin modifications in human T cells based on a proposed closeness measure. | BACKGROUND: Eukaryotic transcription is accompanied by combinatorial chromatin modifications that serve as functional epigenetic markers. Composition of chromatin modifications specifies histone codes that regulate the associated gene. Discovering novel chromatin regulatory relationships are of general interest.METHODO... | ['Algorithms', 'Bayes Theorem', 'Cell Communication', 'Chromatin', 'Computational Biology', 'CpG Islands', 'DNA Methylation', 'Epigenesis, Genetic', 'Histones', 'Humans', 'Models, Statistical', 'Software', 'T-Lymphocytes'] | 21,151,929 | [['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['G04.085'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['H01.158.273.180', 'L01.313.124'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
A partnership for community-based nursing experience: Head Start/Harper College. | In an effort to provide a meaningful community-based nursing experience for the students of William Rainey Harper College, a project was developed with the Community Economic Development Association of Cook County, Illinois to link second-year nursing students and clients in a Head Start program. The goals were designe... | ['Child, Preschool', 'Community Health Nursing', 'Cooperative Behavior', 'Early Intervention, Educational', 'Education, Nursing, Baccalaureate', 'Humans', 'Illinois'] | 10,337,120 | [['M01.060.406.448'], ['H02.478.676.150', 'N02.421.143.150'], ['F01.145.813.115'], ['N02.421.143.130.320', 'N02.421.726.320'], ['I02.358.462.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.567.875.510.350']] | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Impact of collateral damage to endourologic tools during laser lithotripsy--in vitro comparison of three different clinical laser systems. | BACKGROUND AND PURPOSE: During laser lithotripsy, working instruments are often in close proximity to the distal fiber tip and may be damaged accidentally or even intentionally. The aim of this study was to compare the amount of damage to a standard guidewire and the nitinol wires of endourologic retrieval baskets that... | ['Endoscopes', 'Equipment Safety', 'Lasers', 'Lasers, Solid-State', 'Lithotripsy, Laser'] | 21,381,958 | [['E07.230.220', 'E07.858.240'], ['E05.330'], ['E07.632.490', 'E07.710.520'], ['E07.632.490.490', 'E07.710.520.490'], ['E02.594.550', 'E02.600.500', 'E04.014.520.550', 'E04.943.500.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fabrication of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biocomposites with reinforcement by hydroxyapatite using extrusion processing. | The aim of this study was to prepare poly(3-hydroxybutyrate-co-3-hydroxyvalerate), PHBV, biocomposites with incorporating various percentages of hydroxyapatite (HAP) using extrusion processing. The biocomposites were produced by melt extrusion of PHBV with untreated HAP and surface-treated HAP crystals. The structure o... | ['Biocompatible Materials', 'Calorimetry, Differential Scanning', 'Durapatite', 'Elastic Modulus', 'Microscopy, Electron, Scanning', 'Nanocomposites', 'Polyesters', 'Spectroscopy, Fourier Transform Infrared', 'Surface Properties'] | 27,157,723 | [['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.196.131.310', 'E05.196.370.310'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['G01.374.590.605'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512.150'], ['D0... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Design and Evaluation of a New National Pharmacy Internship Program in Ireland. | Objective. To design, deliver, and evaluate a National Pharmacy Internship Program that met the educational requirements of pharmacy graduates to register as competent pharmacists and earned graduates a master's level degree. Methods. The National Pharmacy Internship Program was designed as a 12-month, full-time, blend... | ['Adult', 'Clinical Competence', 'Competency-Based Education', 'Education, Pharmacy', 'Educational Measurement', 'Female', 'Humans', 'Ireland', 'Male', 'Pharmacists', 'Pharmacy Residencies', 'Preceptorship', 'Students, Pharmacy'] | 31,223,152 | [['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158.210'], ['I02.358.525'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['M01.526.485.780', 'N02.360.780'], ['I02.358.525.741', 'I02.358.750.500'], ['I02.358.968'], ['M01.848.769.768']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Treatment goals in psoriasis from a patient perspective: a qualitative study. | Background: Psoriasis is a chronic inflammatory skin disorder with marked impact on quality of life. In view of the well-recognized need to integrate the patient perspective in psoriasis care, treatment goals which originate entirely from the experiences of the patients are of utmost importance.Objective: To explore tr... | ['Adolescent', 'Adult', 'Aged', 'Chronic Disease', 'Dermatologic Agents', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Psoriasis', 'Qualitative Research', 'Quality of Life', 'Young Adult'] | 30,482,070 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['D27.505.954.444'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', ... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Pheno... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women. | Estrogens play a significant role in breast cancer development and are not only produced endogenously, but are also mimicked by estrogen-like compounds from environmental exposures. We evaluated associations between estrogenic (E) activity, demographic factors and breast cancer risk factors in Non-Latina Black (NLB), N... | ['Adult', 'Aged', 'Breast Neoplasms', 'Case-Control Studies', 'Estrogens', 'Ethnic Groups', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Middle Aged', 'Population Groups', 'San Francisco', 'Young Adult'] | 30,908,519 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D27.505.696.399.472.277'], ['M01.686.754', 'N01.224.317'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.63... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Identification of differentially expressed microRNAs in acute Kawasaki disease. | The present study used microarray analysis to screen the plasma expression of microRNAs (miRNAs) in patients with acute Kawasaki disease (KD) and aimed to explore the pathogenesis of KD. Plasma was collected from children with acute KD (n=6) and from healthy control children (n=6). Total RNA was extracted and different... | ['Acute Disease', 'Case-Control Studies', 'Child, Preschool', 'Computational Biology', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Gene Ontology', 'Gene Regulatory Networks', 'Humans', 'Infant', 'Male', 'MicroRNAs', 'Mucocutaneous Lymph Node Syndrome', 'RNA, Messenger', 'Signal Transduction', ... | 29,115,644 | [['C23.550.291.125'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406.448'], ['H01.158.273.180', 'L01.313.124'], ['E05.393.332'], ['G05.308'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01.313.500.750.300.550.500.500', 'L01.453.24... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Effects of E2 and E2/norgestimate hormone therapy on elevated baseline lipids. | OBJECTIVE: To evaluate lipid effects of estradiol/ norgestimate hormone therapy in postmenopausal women with elevated lipid levels.STUDY DESIGN: Postmenopausal women were randomized to E2, 1 mg/intermittent norgestimate (NGM) 90 microg (n = 31), or opposed E2, 1 mg (n = 36), in a 12-month trial. A subset analysis was c... | ['Adult', 'Aged', 'Cholesterol', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Estradiol', 'Estrogen Replacement Therapy', 'Female', 'Humans', 'Hyperlipidemias', 'Hypolipidemic Agents', 'Lipid Metabolism', 'Middle Aged', 'Norges... | 16,967,629 | [['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['G07.690.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis. | 6-Phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3 (PFKFB3) has been reported to be overexpressed in human cancer tissues and to promote the proliferation and migration of cancer cells. However, the role of PFKFB3 in the progression and prognosis of breast cancer is not yet fully understood. In the present study, ... | ['Adult', 'Animals', 'Breast', 'Breast Neoplasms', 'Cell Cycle', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cyclin-Dependent Kinase Inhibitor p27', 'Disease Progression', 'Female', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice... | 29,393,396 | [['M01.060.116'], ['B01.050'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['G04.144'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.360.225.600', 'D12.776.167.187.600', 'D12.776.476.225.600', 'D12.776.624.776.355.600'], ... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification of inositol 1,4,5-trisphosphate binding in human pheochromocytoma. | An attempt was made to identify a specific binding of inositol 1,4,5-trisphosphate (IP3) to human chromaffin cell tumors. Crude microsomal fractions of pheochromocytomas possessed significant binding sites for [3H]IP3 with high- and low-affinity constants (Kd = 5.46 and 538 nM, respectively). The binding to these sites... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Adrenal Medulla', 'Adult', 'Binding, Competitive', 'Female', 'Humans', 'Inositol 1,4,5-Trisphosphate', 'Male', 'Microsomes', 'Middle Aged', 'Pheochromocytoma'] | 1,641,075 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['A06.300.071.265'], ['M01.060.116'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.800.519.400.350', 'D09.853.519.400.350', 'D09.894.480.350'], ['A11.284.835.540'], ['M01.060.116... | ['Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure and characterization of the mouse UT-A gene (Slc14a2). | The movement of urea across plasma membranes is modulated by facilitated urea transporter proteins. These proteins are the products of two closely related genes, termed UT-A (Slc14a2) and UT-B (Slc14a1). By genomic library screening and P1 artificial chromosome "shotgun" sequencing, we have determined the structure of ... | ['Animals', 'Base Sequence', 'Blotting, Northern', 'Carrier Proteins', 'Cells, Cultured', 'Cloning, Molecular', 'DNA, Complementary', 'Exons', 'Gene Expression Regulation', 'Introns', 'Membrane Glycoproteins', 'Membrane Transport Proteins', 'Mice', 'Mice, Knockout', 'Molecular Sequence Data', 'Plasmids', 'Promoter Regi... | 11,880,324 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D12.776.157'], ['A11.251'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['G05.308'], ['G05.360.340.024.22... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[A case of tracheal amyloidosis discovered during observation of interstitial pneumonia]. | A 73-year-old man was admitted to our hospital because of fever, productive cough and dyspnea on exertion in March 1998. He had been treated at our hospital for interstitial pneumonia. Chest radiographs showed consolidations and honeycomb shadows in both lungs. He also had a chronic subdural hematoma. After admission h... | ['Amyloidosis', 'Bronchoscopy', 'Humans', 'Lung Diseases, Interstitial', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed', 'Tracheal Diseases'] | 12,692,998 | [['C18.452.845.500'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.483'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats. | The combined effects of endurance run training and renal hypertension on cytosolic Ca2+ concentration ([Ca2+]c) dynamics and Na+-dependent Ca2+ regulation in rat left ventricular cardiomyocytes were examined. Male Fischer 344 rats underwent stenosis of the left renal artery [hypertensive (Ht), n = 18] or a sham operati... | ['Animals', 'Caffeine', 'Calcium', 'Cardiac Pacing, Artificial', 'Diastole', 'Fluorescent Dyes', 'Fura-2', 'Heart', 'Hypertension, Renal', 'Male', 'Myocardium', 'Phosphodiesterase Inhibitors', 'Physical Conditioning, Animal', 'Rats', 'Rats, Inbred F344', 'Sodium'] | 11,356,766 | [['B01.050'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E02.331.200'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D03.383.129.462.285', 'D03.633.100.127.250'], ['A07.541'], ['C12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The random urine estrogen, pregnanediol/creatinine ratio determinations for monitoring ovarian function]. | Study was made to assess the potential clinical value of a random urine estrogen, pregnanediol/creatinine ratio (E/C, P/C) determinations as an index of monitoring ovarian function. Radioimmunoassay of total estrogens and pregnanediol was carried out on 24 hour and paired early morning urine samples in 14 healthy volun... | ['Adolescent', 'Adult', 'Anovulation', 'Creatinine', 'Estrogens', 'Female', 'Humans', 'Ovarian Function Tests', 'Ovary', 'Pregnanediol', 'Radioimmunoassay'] | 6,715,918 | [['M01.060.057'], ['M01.060.116'], ['C13.351.500.056.630.050', 'C19.391.630.050', 'G08.686.784.690.080'], ['D03.383.129.308.207'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.374.530', 'E01.370.378.530'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['D04.21... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Midwifery: home and away. | The challenges faced by birthing women and maternity healthcare professionals in developing countries cannot not be over estimated. The experience of a midwife in a rural Tanzanian hospital described in this article gives a small insight into these challenges. With intermittent electricity, no running water, three beds... | ['Attitude to Health', 'Culturally Competent Care', 'Delivery, Obstetric', 'Developing Countries', 'Female', 'Home Childbirth', 'Humans', 'Infant', 'Midwifery', 'Nurses, International', 'Pregnancy', 'Rural Population', 'Tanzania', 'United Kingdom'] | 26,975,129 | [['F01.100.150', 'N05.300.150'], ['N04.590.374.052', 'N05.300.206'], ['E04.520.252'], ['I01.615.500.300'], ['G08.686.784.769.490.062.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['H02.478.676.416'], ['M01.526.407.717', 'M01.526.485.650.662', 'N02.360.650.662'], ['G08.686.784.769'], ['N01.600... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Enantioselective synthesis of beta-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine. | Beta-amino esters are readily formed from the rhodium(II) prolinate-catalyzed intermolecular C-H insertion between methyl aryldiazoacetates and a bis-silyl protected methylamine. | ['Amines', 'Amino Acids', 'Analgesics', 'Antidepressive Agents, Second-Generation', 'Catalysis', 'Cyclohexanols', 'Diazonium Compounds', 'Esters', 'Methylamines', 'Proline', 'Rhodium', 'Stereoisomerism', 'Venlafaxine Hydrochloride'] | 16,855,702 | [['D02.092'], ['D12.125'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D27.505.954.427.700.122.050'], ['G02.130'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['D02.172.383'], ['D02.241.400'], ['D02.092.668'], ['D12.125.072.401.623'], ['D01.268.556.793', 'D01.268.956.781', 'D01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Solvolysis and metabolic degradation, by rat liver, of the ultimate carcinogen, N-sulfonoxy-2-acetylaminofluorene. | The synthetic ultimate carcinogen, N-sulfonoxy-2-acetylaminofluorene (K+ salt, N-OSO3K-2-AAF), undergoes several solvolytic and metabolic reactions that have not been reported heretofore. In aqueous media, 45-50% of N-OSO3K-2-AAF is converted to 4-hydroxy-2-acetylaminofluorene, presumably by the ionic mechanism propose... | ['2-Acetylaminofluorene', 'Animals', 'Cytosol', 'Liver', 'Male', 'Rats', 'Rats, Inbred Strains', 'Spectrophotometry, Ultraviolet'] | 3,574,289 | [['D02.065.064.150', 'D02.241.081.018.110.080', 'D02.455.426.559.847.389.050', 'D04.615.389.050'], ['B01.050'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['E... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic diversity of bradyrhizobial populations from diverse geographic origins that nodulate Lupinus spp. and Ornithopus spp. | The genetic diversity of 45 bradyrhizobial isolates that nodulate several Lupinus and Ornithopus species in different geographic locations was investigated by 16S rDNA PCR-RFLP and sequence analysis, 16S-23S rDNA intergenic spacer (IGS) PCR-RFLP analysis, and ERIC-PCR genomic fingerprinting. Reference strains of Bradyr... | ['Bacterial Proteins', 'Bradyrhizobium', 'DNA Fingerprinting', 'DNA, Bacterial', 'DNA, Ribosomal', 'DNA, Ribosomal Spacer', 'Ecology', 'Fabaceae', 'Genetic Variation', 'Genotype', 'Lupinus', 'Molecular Sequence Data', 'N-Acetylglucosaminyltransferases', 'Phylogeny', 'Polymerase Chain Reaction', 'Polymorphism, Restricti... | 14,666,990 | [['D12.776.097'], ['B03.440.400.425.200.090', 'B03.660.050.035.090'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.212'], ['D13.444.308.475'], ['D13.444.308.324.230', 'D13.444.308.475.230'], ['H01.158.273.248', 'H01.277.249'], ['B01.650.940.800.575.912.250.401'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
The effect of Baduanjin qigong combined with CBT on physical fitness and psychological health of elderly housebound. | BACKGROUND: To investigate the effectiveness of Baduanjin qigong combined with cognitive-behavior therapy (CBT) on the physical fitness and psychological health of elderly housebound.MATERIALS AND METHODS: The 120 elderly housebound were randomly divided into 3 intervention groups: Baduanjin training, Baduanjin trainin... | ['Aged', 'Aged, 80 and over', 'Cognitive Behavioral Therapy', 'Combined Modality Therapy', 'Depression', 'Female', 'House Calls', 'Humans', 'Loneliness', 'Male', 'Maximal Voluntary Ventilation', 'Mental Health', 'Middle Aged', 'Physical Fitness', 'Qigong', 'Quality of Life', 'Treatment Outcome', 'Vital Capacity'] | 30,572,482 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F04.754.137.350'], ['E02.186'], ['F01.145.126.350'], ['N04.452.758.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.470.713', 'I01.880.853.748.435'], ['E01.370.386.700.660.500', 'G09.772.650.630'], ['F02.418', 'N01.400.500'], ['M01.060.116.630'], ['G11.427.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Disparate hypervariable region-1 of mitochondrial DNA did not induce skin allograft rejection in cloned porcine models. | INTRODUCTION: Alloantigen recognition in skin transplantation is the bane for surgeons. Several studies have mainly focused on the immunogenicity of major histocompatibility (MHC) antigens and H-Y minor histocompatibility antigens. However, the roles of the mitochondrial DNA (mtDNA) encorded miHA have not been identifi... | ['Animals', 'Base Sequence', 'Cloning, Organism', 'DNA Primers', 'DNA, Mitochondrial', 'Graft Rejection', 'Major Histocompatibility Complex', 'Models, Animal', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Sequence Homology, Nucleic Acid', 'Skin Transplantation', 'Swine'] | 23,769,044 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.240', 'E05.820.180'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.283.225'], ['G12.875.545.328'], ['G05.360.340.024.340.610', 'G05.360.340.024.380.500', 'G12.500.500'], ['E05.598'], ['L01.453.245.667'], ['E0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Moral Injury: Contextualized Care. | Amidst the return of military personnel from post-9/11 conflicts, a construct describing the readjustment challenges of some has received increasing attention: moral injury. This term has been variably defined with mental health professionals more recently conceiving of it as a transgression of moral beliefs and expect... | ['Chaplaincy Service, Hospital', 'Humans', 'Morals', 'Stress Disorders, Post-Traumatic', 'Veterans'] | 29,027,618 | [['N02.278.216.500.968.270', 'N04.452.442.452.422.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.500', 'K01.752.566'], ['F03.950.750.500'], ['M01.930']] | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The plastoquinone pool outside the thylakoid membrane serves in plant photoprotection as a reservoir of singlet oxygen scavengers. | The Arabidopsis vte1 mutant is devoid of tocopherol and plastochromanol (PC-8). When exposed to excess light energy, vte1 produced more singlet oxygen (1 O2 ) and suffered from extensive oxidative damage compared with the wild type. Here, we show that overexpressing the solanesyl diphosphate synthase 1 (SPS1) gene in v... | ['Alkyl and Aryl Transferases', 'Arabidopsis Proteins', 'Chlorophyll', 'Chloroplasts', 'Chromatography, High Pressure Liquid', 'Electron Spin Resonance Spectroscopy', 'Free Radical Scavengers', 'Light', 'Lipid Peroxidation', 'Oxidative Stress', 'Plastoquinone', 'Singlet Oxygen', 'Thylakoids'] | 29,601,642 | [['D08.811.913.225'], ['D12.776.765.149'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['A11.284.430.214.190.875.700.140'], ['E05.196.181.400.300'], ['E05.196.867.519.274'], ['D27.505.519.217.500'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G02.111.515', ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rhodanobacter lindaniclasticus gen. nov., sp. nov., a lindane-degrading bacterium. | Lindane-degrading activity under aerobic conditions has been observed in two bacterial strains: UT26, phenotypically identified as Sphingomonas paucimobilis, and a new single unidentified isolate named RP5557T. The rrs (16S rDNA) sequences for both strains and the phenotypic characteristics for the unidentified isolate... | ['Bacteria, Aerobic', 'Base Sequence', 'Cloning, Molecular', 'Hexachlorocyclohexane', 'Molecular Sequence Data', 'Phylogeny'] | 10,028,243 | [['B03.120'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D02.455.526.439.600'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. | PURPOSE: Fluid transport by the corneal endothelium is dependent on the presence of HCO(3)(-) and the activity of carbonic anhydrase (CA)-II and -IV, the cytoplasmic and membrane-bound CAs, respectively. This study was conducted to examine the inhibition of CA activity in cultured bovine corneal endothelial cells (BCEC... | ['Animals', 'Bicarbonates', 'Carbonates', 'Carbonic Anhydrase Inhibitors', 'Cattle', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Endothelium, Corneal', 'Female', 'Hydrogen-Ion Concentration', 'Isotonic Solutions', 'Osmolar Concentration', "Ringer's Solution", 'Sulfonamides', 'Thiophenes'] | 12,356,834 | [['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['D27.505.519.389.200'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['G02.300... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Partitioning of pulmonary impedance: modeling vs. alveolar capsule approach. | Pulmonary input impedance (ZL), transfer tissue impedances (Ztti), and transfer airway impedances (Ztaw) were measured in open-chest dogs and isolated canine lungs by means of small-amplitude pseudorandom oscillations between 0.2 and 21.1 Hz. In the determination of Ztti and Ztaw, local alveolar pressures (PA) sensed i... | ['Airway Resistance', 'Animals', 'Dogs', 'Elasticity', 'In Vitro Techniques', 'Lung', 'Models, Biological', 'Pulmonary Alveoli'] | 8,226,447 | [['E01.370.386.700.050', 'G09.772.060'], ['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['G01.374.590'], ['E05.481'], ['A04.411'], ['E05.599.395'], ['A04.411.715']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Much gained by integrating contact tracing and vaccination in the hepatitis B antenatal screening program in Amsterdam, 1992-1999. | BACKGROUND/AIMS: Hepatitis B control in Europe concentrates on antenatal screening to reduce vertical transmission. To reduce horizontal transmission and the pool of infectious individuals, the Municipal Health Service of Amsterdam integrated tracing and immunising of contacts in the antenatal screening program.METHODS... | ['Contact Tracing', 'Female', 'Hepatitis B', 'Hepatitis B Vaccines', 'Humans', 'Infant, Newborn', 'Mass Screening', 'Netherlands', 'Pregnancy', 'Prenatal Care', 'Risk Assessment'] | 15,158,339 | [['E05.318.270', 'N06.850.520.270', 'N06.850.780.200.225'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D20.215.894.899.955.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5. | Effectors of the Rab small GTPases are large multi-domain proteins which have proved difficult to express in soluble form in Escherichia coli. Generally, effectors are recruited to a distinct subcellular compartment by active (GTP-bound) Rabs, which are linked to membranes by one or two prenylated Cys residues at their... | ['Amino Acid Sequence', 'Animals', 'Crystallization', 'Crystallography, X-Ray', 'Humans', 'Mice', 'Molecular Sequence Data', 'Protein Engineering', 'Sequence Alignment', 'rab GTP-Binding Proteins'] | 21,543,860 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['E05.393.420.601'], ['E05.393.751'], ['D08.811.277.040.330.300.400.400', 'D12.644.360.525.400... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Abiotic origin of biopolymers. | A variety of methods have been investigated in different laboratories for the polymerization of amino acids and nucleotides under abiotic conditions. They include (1) thermal polymerization, (2) direct polymerization of certain amino acid nitriles, amides or esters, (3) pi, Tokyo 194, Japan. | ['Adenosine Triphosphate', 'Catalysis', 'Chemical Phenomena', 'Chemistry', 'Hot Temperature', 'Imidazoles', 'Oligonucleotides', 'Oligopeptides'] | 967,403 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.130'], ['G02'], ['H01.181'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D03.383.129.308'], ['D13.695.578.424'], ['D12.644.456']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Purification, subunit structure and pharmacological effects on cardiac and smooth muscle cells of a polypeptide toxin isolated from the marine snail Conus tessulatus. | The most active component in smooth muscle contraction, isolated from the whole venom of the marine snail Conus tessulatus, has a molecular mass of about 55 kDa. The toxin protein, tessulatus toxin, appeared to be constituted by two distinct polypeptide bands of 26 kDa and 29 kDa. The pure toxin caused a marked contrac... | ['Animals', 'Calcium', 'Cell Survival', 'Electrophoresis, Polyacrylamide Gel', 'Guinea Pigs', 'Heart', 'In Vitro Techniques', 'Ion Channels', 'Membrane Potentials', 'Mollusk Venoms', 'Muscle, Smooth', 'Myocardium', 'Rabbits', 'Snails', 'Sodium'] | 2,431,907 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.346'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['E05.481'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['D20.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. | BACKGROUND: Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults.METHODS AND RESULTS: As part of the longitudinal Cardiovasc... | ['Adolescent', 'Adult', 'Arteriosclerosis', 'Blood Glucose', 'Body Mass Index', 'Brachial Artery', 'C-Reactive Protein', 'Cardiovascular Diseases', 'Carotid Artery, Common', 'Child', 'Child, Preschool', 'Cholesterol', 'Cohort Studies', 'Coronary Disease', 'Cross-Sectional Studies', 'Endothelium, Vascular', 'Female', 'F... | 15,505,080 | [['M01.060.057'], ['M01.060.116'], ['C14.907.137.126'], ['D09.947.875.359.448.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['A07.015.114.139'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C14'], ['A07.015.114.186.200'], ['M01.060.406'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Freeze-thaw effects on phosphorus loss in runoff from manured and catch-cropped soils. | Concern over nonpoint source P losses from agricultural lands to surface waters in frigid climates has focused attention on the role of freezing and thawing on P loss from catch crops (cover crops). This study evaluated the effect of freezing and thawing on the fate of P in bare soils, soils mixed with dairy manure, an... | ['Agriculture', 'Climate', 'Freezing', 'Lolium', 'Manure', 'Pennsylvania', 'Phosphorus', 'Soil'] | 16,275,731 | [['J01.040'], ['G16.500.275.071', 'N06.230.300.100.250'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.650.940.800.575.912.250.822.500'], ['D20.601'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['D01.268.666'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.23... | ['Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
The role of pre-treatment MRI in established cases of slipped capital femoral epiphysis. | BACKGROUND: Slipped capital femoral epiphysis (SCFE) often results in functional impairment and premature osteoarthritis despite surgical treatment. Treatment decisions are commonly based on the clinical history and radiographic appearance. This study assesses the pre-treatment features of SCFE and correlates them to t... | ['Adolescent', 'Child', 'Epiphyses, Slipped', 'Female', 'Femur', 'Hip Injuries', 'Hip Joint', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Preoperative Care'] | 18,439,779 | [['M01.060.057'], ['M01.060.406'], ['C05.116.425'], ['A02.835.232.043.150'], ['C26.531'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Release of chemoattractants for human monocytes from endothelial cells by interaction with neutrophils. | OBJECTIVE: The release of monocyte chemoattractant protein-1 (MCP-1) in the vessel wall may lead to accumulation of monocytes in the subendothelial space. The role of neutrophils (PMNL) in the initiation of this process is unknown. We tested whether PMNL are able to induce the production and release of MCP-1 in endothe... | ['Arteriosclerosis', 'Cell Communication', 'Cells, Cultured', 'Chemokine CCL2', 'Chemotaxis, Leukocyte', 'Coculture Techniques', 'Cycloheximide', 'Endothelium, Vascular', 'Humans', 'Leukocytes, Mononuclear', 'Neutrophils', 'Protein Synthesis Inhibitors', 'Time Factors'] | 9,709,414 | [['C14.907.137.126'], ['G04.085'], ['A11.251'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['G04.198.424.233'], ['E05.481.500.374'], ['D03.383.621.808.240'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.05... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prospective payment for nursing homes increased therapy provision without improving community discharge rates. | OBJECTIVES: To determine the impact of the prospective payment system (PPS) for skilled nursing facilities (SNFs) on therapy use and community discharge rates.DESIGN: Quasi-experimental study examining the predemonstration (1994) to demonstration (1997) change in amount of therapy provided, and in community discharge r... | ['Aged', 'Diagnosis-Related Groups', 'Humans', 'Likelihood Functions', 'Medicare', 'Multivariate Analysis', 'Nursing Homes', 'Occupational Therapy', 'Outcome Assessment, Health Care', 'Patient Discharge', 'Physical Therapy Modalities', 'Prospective Payment System', 'Recovery of Function', 'Regression Analysis', 'Rehabi... | 11,555,069 | [['M01.060.116.100'], ['N03.219.521.710.305.200.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['N03.219.521.346.506.564.663', 'N03.219.... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. | Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection. Interleukin 23 (IL-23) was essential for the accelerated response, for early cessation of ... | ['Adjuvants, Immunologic', 'Animals', 'Antigens, Bacterial', 'Bacterial Proteins', 'CD4-Positive T-Lymphocytes', 'Cytokines', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Flow Cytometry', 'Immunohistochemistry', 'Interleukin-17', 'Interleukin-23', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Transg... | 17,351,619 | [['D27.505.696.477.067'], ['B01.050'], ['D23.050.161'], ['D12.776.097'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Socioeconomic status and the course of quality of life in older patients with coronary heart disease. | BACKGROUND: Previous research suggests that socioeconomic status (SES) might be related to the course of quality of life (QoL) in coronary heart disease (CHD) patients. The authors sought to determine whether there are differences in the course of QoL before and after the incidence of CHD among older persons of differi... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Anxiety', 'Comorbidity', 'Coronary Disease', 'Depression', 'Female', 'Health Status Disparities', 'Heart Failure', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Netherlands', 'Prognosis', 'Prospective Studies', 'Quality of Life', 'Sick R... | 19,288,210 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.470.132'], ['N05.715.350.225', 'N06.850.490.687'], ['C14.280.647.250', 'C14.907.585.250'], ['F01.145.126.350'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['C14.280.434'], ['B01.050.150.900.649.313.988.4... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Causes and outcome of prenatally diagnosed hydronephrosis. | Hydronephrosis is the most common abnormal finding in the urinary tract on prenatal screening with ultrasonography (U/S). Hydronephrosis may be obstructive or non-obstructive; obstructive lesions are more harmful to the developing kidneys. The aim of the study was to evaluate the causes of renal pelvic dilatation and t... | ['Diagnosis, Differential', 'Dilatation, Pathologic', 'Female', 'Humans', 'Hydronephrosis', 'Infant, Newborn', 'Kidney Pelvis', 'Male', 'Pregnancy', 'Prognosis', 'Prospective Studies', 'Ultrasonography, Prenatal', 'Ureteral Diseases'] | 19,237,812 | [['E01.171'], ['C23.300.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.307', 'C13.351.968.419.307'], ['M01.060.703.520'], ['A05.810.453.537'], ['G08.686.784.769'], ['E01.789'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.850.865', 'E01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
No evidence of measles virus in stapes samples from patients with otosclerosis. | Otosclerosis is a localized bone dystrophy of unknown etiology mainly involving the stapes. The hypothesis of a persistent infection by the measles virus was based on the inconstant detection of the virus by various methods, including reverse transcription-PCR (RT-PCR) of patients' stapes samples. The aim of this work ... | ['Adult', 'Animals', 'Audiometry', 'Blotting, Southern', 'Cells, Cultured', 'Chlorocebus aethiops', 'Coculture Techniques', 'Female', 'Humans', 'Male', 'Measles', 'Measles virus', 'Middle Aged', 'Otosclerosis', 'RNA, Viral', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Stapes', 'Ve... | 10,878,059 | [['M01.060.116'], ['B01.050'], ['E01.370.382.375.060'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.481.500.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.925.782.580.600.500.500'], ['B04.820.480.937.600.650.500.500'],... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytokine networking in lung inflammation. | The molecules that mediate normal events in the lung also regulate the development and ultimate resolution of pulmonary inflammation. And they can orchestrate such fulminant, life-threatening disorders as septic shock. Which cytokines are involved, and how may their physiologic roles be subverted? Interleukins and tumo... | ['Cytokines', 'Homeostasis', 'Humans', 'Lung', 'Pneumonia', 'Shock, Septic'] | 2,120,257 | [['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['C01.757.800', 'C23.550.470.790.500.800', 'C23.550.835.900.712']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Education of garment workers: prevention of work related musculoskeletal disorders. | This educational intervention was designed as part of a garment worker occupational health and safety initiative, with the goal to reduce musculoskeletal symptoms in this monolingual Cantonese speaking population. Using risk communication and the Chinese concepts of yin and yang, the class curriculum was designed to be... | ['Attitude to Health', 'China', 'Emigration and Immigration', 'Ergonomics', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Middle Aged', 'Musculoskeletal Diseases', 'Occupational Diseases', 'Occupational Health Nursing', 'Occupational Health Services', 'Patient Education as Topic', 'Program Development',... | 15,357,372 | [['F01.100.150', 'N05.300.150'], ['Z01.252.474.164'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['F02.784.412', 'J01.293.556'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05'], ['C24'], ['H02.478.676.590', 'N02.42... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Technique... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Nicotinic acid treatment shifts the fibrinolytic balance favourably and decreases plasma fibrinogen in hypertriglyceridaemic men. | BACKGROUND: Nicotinic acid in gram doses decreases cholesterol and triglyceride concentrations in plasma, but the effect on haemostatic function is not known.METHODS: Twenty-three men with hypertriglyceridaemia were treated with 4 g nicotinic acid daily for 6 weeks. Tests for haemostatic function and serum lipoproteins... | ['Administration, Oral', 'Adult', 'Aged', 'Analysis of Variance', 'Blood Glucose', 'Drug Administration Schedule', 'Enzyme-Linked Immunosorbent Assay', 'Fibrinogen', 'Hemostasis', 'Humans', 'Hypertriglyceridemia', 'Lipoproteins', 'Lipoproteins, HDL', 'Lipoproteins, VLDL', 'Male', 'Middle Aged', 'Niacin', 'Plasminogen A... | 9,475,670 | [['E02.319.267.100'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D09.947.875.359.448.500'], ['E02.319.283'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.124.050.250', 'D12.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Computer-assisted analysis of chromosomes of the European crested newt. | A computer programme has been developed for partly automating the process of chromosome analysis of the European crested newt (Triturus cristatus carnifex). Chromosome classifications made by the computer and by the cytologist have been compared for a sample of 130 spermatogonial metaphase. The twelve pairs of chromoso... | ['Animals', 'Chromosomes', 'Computers', 'Karyotyping', 'Triturus'] | 7,273,853 | [['B01.050'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['L01.224.230.260'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['B01.050.150.900.090.608.700.670']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Combined neuronal and endocrine tumors of the sellar region]. | Gangliocytomas or gangliogliomas of the sellar region are very rare tumors. In a great proportion of those cases an adenoma of the anterior pituitary develops from the cell type that is hyperstimulated by the releasing hormone produced from the gangliocytoma. Five GHRH secreting gangliocytomas are reported. Four of the... | ['Acromegaly', 'Adenoma', 'Adult', 'Aged', 'Child', 'Female', 'Ganglioneuroma', 'Growth Hormone-Releasing Hormone', 'Human Growth Hormone', 'Humans', 'Male', 'Middle Aged', 'Pituitary Neoplasms', 'Sella Turcica', 'Vasopressins'] | 9,451,729 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['C04.557.465.625.600.355', 'C04.557.470.670.355', 'C04.557.580.625.600.355'], ['D06.472.699.327.740.860', 'D12.644.400.400.740.860', 'D12.644.548.365.740.860', 'D12.776.63... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Epigenetic markers in migrating population burial sites of the Mid-Elbe-Saale area]. | The distribution of 122 epigenetic traits of the cranium and the postcranial skeleton (180 skeletal individuals) of six sites of the period of the Middleelbe-Saale-Region was analyzed. Based on these frequencies and using the method of biodistance analysis (MMD after Sj?vold 1973) the relationships of these population ... | ['Adult', 'Age Determination by Skeleton', 'Bone and Bones', 'Burial', 'Cephalometry', 'Child', 'Ethnic Groups', 'Female', 'Germany', 'History, Ancient', 'Humans', 'Infant, Newborn', 'Male', 'Middle Aged', 'Paleopathology', 'Skull'] | 11,838,045 | [['M01.060.116'], ['E01.370.049', 'E01.370.350.700.050'], ['A02.835.232', 'A10.165.265'], ['I01.076.201.450.550.150'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['M01.060.406'], ['M01.686.754', 'N01.224.317'], ['Z01.542.315'], ['K01.400.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Epidermal growth factor tyrosine kinase inhibitors used in the treatment of NSCLC patients with leptomeningeal metastasis]. | Objective: The aim of this study was to identify the clinical features and prognostic factors of leptomeningeal metastasis (LM) in non-small cell lung cancer (NSCLC) patients undergoing treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). Methods: Twenty-five cases of NSCLC with LM,... | ['Adenocarcinoma', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'EGF Family of Proteins', 'ErbB Receptors', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Meningeal Neoplasms', 'Multivariate Analysis', 'Protein Kinase Inhibitors', 'Retrospective Studies', 'Sex Factors'] | 27,998,469 | [['C04.557.470.200.025'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D12.644.276.382', 'D12.776.467.382', 'D23.529.382'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.40... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Work absenteeism by parents because of oral conditions in preschool children. | OBJECTIVE: The aim of the present study was to evaluate the influence of oral conditions in preschool children and associated factors on work absenteeism experienced by parents or guardians.METHODS: A preschool-based, cross-sectional study was conducted of 837 children, 3-5 years of age, in Campina Grande, Brazil. Pare... | ['Absenteeism', 'Age Factors', 'Attitude to Health', 'Brazil', 'Child Health', 'Child, Preschool', 'Cross-Sectional Studies', 'Dental Caries', 'Educational Status', 'Family Health', 'Female', 'Health Status', 'Humans', 'Income', 'Male', 'Oral Health', 'Parents', 'Quality of Life', 'Tooth Avulsion', 'Tooth Injuries', 'T... | 26,397,722 | [['F02.784.692.107'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.100.150', 'N05.300.150'], ['Z01.107.757.176'], ['N01.400.225'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C07.793.720.210'], ['N01.824.196'], ['N01.400.300'], ['I01.240.425', 'N01.224.425', 'N... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs. | The fibroblast growth factor (FGF) family plays a key role in a multitude of physiological and pathological processes. The activities of FGFs are mediated by a family of tyrosine kinase receptors, designated FGFRs. The mechanism by which FGFs induce receptor activation is controversial. Despite their structural similar... | ['3T3 Cells', 'Animals', 'Binding Sites', 'Cell Line', 'Dose-Response Relationship, Drug', 'Fibroblast Growth Factor 10', 'Fibroblast Growth Factor 2', 'Fibroblast Growth Factor 7', 'Fibroblast Growth Factors', 'Growth Substances', 'Humans', 'Kinetics', 'Mice', 'Models, Molecular', 'Mutagenesis', 'Phosphorylation', 'Po... | 10,574,979 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['G02.111.570.120'], ['A11.251.210'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.276.624.200', 'D12.776.467.624.200', 'D23.529.624.200'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['D12.644.276.624.170', 'D12.776.467.624.170', 'D23.52... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. | Endocytosis of the growth hormone receptor (GHR) is regulated by the ubiquitin-conjugating system. A cytosolic 10 amino acid motif, referred to as the ubiquitin-dependent endocytosis (UbE) motif, is involved in the ubiquitination as well as in the endocytosis of the receptor. Proteins that are implicated in one of thes... | ['Amino Acid Motifs', 'Carrier Proteins', 'Cell Line', 'Endocytosis', 'Humans', 'Molecular Chaperones', 'Proteins', 'Receptors, Somatotropin', 'Ubiquitin'] | 12,735,788 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.157'], ['A11.251.210'], ['G04.417'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.580'], ['D12.776'], ['D12.776.543.750.750.555.770', 'D12.776.543.750.750.660.750'], ['D12.776.947.500']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro osteogenic potential of canine adipose derived stem cells. | Stem cells based tissue engineering is a promising approach for the regenerative treatment of various tissue disorders. Adipose tissue is an abundant source of cells which are competent of multipotential differentiation, called adipose-derived stem cells (ADSCs). The present study was contemplated with the objective of... | ['Adipocytes', 'Adipogenesis', 'Animals', 'Cell Differentiation', 'Cell Lineage', 'Cell Separation', 'Cell Survival', 'Cells, Cultured', 'Dogs', 'Female', 'Gene Expression Regulation, Developmental', 'Homeodomain Proteins', 'Octamer Transcription Factor-3', 'Osteoblasts', 'Osteogenesis', 'Stem Cells', 'Subcutaneous Fat... | 24,196,796 | [['A11.329.114'], ['G04.152.149'], ['B01.050'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G04.346'], ['A11.251'], ['B01.050.150.900.649.313.750.250.216.200'], ['G05.308.310'], ['D12.776.260.400'], ['D12.776... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice. | Generation of a vascular network is a hallmark of solid tumor growth, and attempts to switch off the tumor angiogenic phenotype are promising. However, this angiogenic potential might also be exploited to obtain incorporation into tumor vessels of genetically modified third-party cells, which could behave as targets of... | ['Animals', 'Cell Differentiation', 'Disease Models, Animal', 'Endothelial Growth Factors', 'Endothelium, Vascular', 'Fibroblast Growth Factor 2', 'Fibroblasts', 'Genes, Reporter', 'Graft Survival', 'Humans', 'Immunohistochemistry', 'Intercellular Signaling Peptides and Proteins', 'Lymphokines', 'Mice', 'Mice, SCID', '... | 12,799,179 | [['B01.050'], ['G04.152'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.276.390', 'D12.776.467.390', 'D23.529.390'], ['A07.015.700.500', 'A10.272.491.355'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['A11.329.228'], ['G05.360.340.024.340.435'], ['G12.875.545.340'], ['B01.050.150.900... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Palliative Medicine Family Conferences Reduce Spokesperson Distress and Enhance Communication in Advanced Cancer. | INTRODUCTION: Family conferences (FCs) may be important in communication. There is limited evidence about their value in palliative medicine. We examined specific information needs of patient-identified spokespersons (SP) and if the needs were met by a subsequent FC. Further data were collected on FC attendee character... | ['Adult', 'Aged', 'Aged, 80 and over', 'Communication', 'Decision Making', 'Family', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Palliative Care', 'Palliative Medicine', 'Professional-Family Relations', 'Prospective Studies', 'Stress, Psychological', 'Surveys and Questionnaires'] | 29,727,264 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.209', 'L01.143'], ['F02.463.785.373'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['E02.760.666', 'N02.421.585.666'], ['H02.403.645'], ['F01.829.401.550'], ['E05.318.372.500.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
[Doppler ultrasound results of hemodilution treatment]. | In a double-blind study, 12 patients with an Hb > 13 g/dl in the second trimester, a pretherapeutic hematocrit > 38%, and a fetal aortal resistance index > 0.75 underwent hemodilution. The patients were given either 500 ml hydroxyethyl starch (HAES) or 500 ml NaCl 0.9%. In addition, all patients received 500 ml NaCl 0.... | ['Blood Flow Velocity', 'Double-Blind Method', 'Female', 'Fetal Growth Retardation', 'Gestational Age', 'Humans', 'Hydroxyethyl Starch Derivatives', 'Infant, Newborn', 'Maternal-Fetal Exchange', 'Placental Insufficiency', 'Pregnancy', 'Ultrasonography, Prenatal', 'Vascular Resistance'] | 7,683,447 | [['E01.370.370.130', 'G09.330.380.630.080'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.301.915.500', 'D09.698.365.855.500'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk Factors for Mortality in Severely Ill Children Admitted to a Tertiary Referral Hospital in Malawi. | In low-resource settings, many children are severely ill at arrival to hospital. The risk factors for mortality among such ill children are not well-known. Understanding which of these patients are at the highest risk could assist in the allocation of limited resources to where they are most needed. A cohort study of s... | ['Adolescent', 'Child', 'Child, Preschool', 'Emergency Service, Hospital', 'Female', 'Hospital Mortality', 'Humans', 'Infant', 'Infant, Newborn', 'Intensive Care Units, Pediatric', 'Logistic Models', 'Malawi', 'Male', 'Odds Ratio', 'Prospective Studies', 'Risk Factors', 'Severity of Illness Index', 'Tertiary Care Cente... | 31,287,044 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Detection of vertical transmission of human immunodeficiency virus type 1 by a commercial polymerase chain reaction assay. | In a prospective study, a commercial polymerase chain reaction (PCR) system was compared with a conventional procedure, based on PCR and hybridization with a radio-labeled probe, for the detection of human immunodeficiency virus (HIV) infection in 131 blood samples from 80 children born to HIV-seropositive mothers. Twe... | ['Child', 'Child, Preschool', 'DNA, Viral', 'HIV Infections', 'HIV-1', 'Humans', 'Infant', 'Infant, Newborn', 'Infectious Disease Transmission, Vertical', 'Polymerase Chain Reaction', 'Prospective Studies', 'Sensitivity and Specificity'] | 8,781,885 | [['M01.060.406'], ['M01.060.406.448'], ['D13.444.308.568'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['N06.850.335.87... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of rebamipide on quality of peptic ulcer healing in rat. | The aim of this study is to elucidate the effects and the mechanism of rebamipide, omeprazole, and their combination treatment on quality of peptic ulcer healing (QOUH). Peptic ulcer models were induced by acetic acid exposure of the serosa of rat stomach. Forty Sprague-Dawley (SD) rats were divided randomly into four ... | ['Alanine', 'Animals', 'Anti-Ulcer Agents', 'Dinoprostone', 'Drug Therapy, Combination', 'Gastric Mucosa', 'Interleukin-8', 'Male', 'Omeprazole', 'Peptic Ulcer', 'Proton Pump Inhibitors', 'Quinolones', 'Rats', 'Rats, Sprague-Dawley', 'Reactive Oxygen Species', 'Stomach', 'Ultrasonography'] | 19,082,723 | [['D12.125.042'], ['B01.050'], ['D27.505.954.483.203'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['E02.319.310'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D12.644.276.374.200.120.800', 'D12.644.276.374.465.312', 'D12.776.467.374.200.120.800', 'D12.776.467.374.465.246', 'D23.125.300.120.800',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury - United States, October 2019. | CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical partners are investigating a multistate outbreak of lung injury associated with the use of electronic cigarette (e-cigarette), or vaping, products. In late August, CDC released recommendations for health care... | ['Adolescent', 'Adult', 'Aged', 'Centers for Disease Control and Prevention, U.S.', 'Disease Outbreaks', 'Electronic Nicotine Delivery Systems', 'Female', 'Humans', 'Lung Injury', 'Male', 'Middle Aged', 'Practice Guidelines as Topic', 'United States', 'Vaping', 'Young Adult'] | 31,633,675 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['I01.409.418.750.600.650.200', 'N03.540.348.500.500.600.650.225'], ['N06.850.290'], ['J01.637.767.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.520', 'C26.891.554'], ['M01.060.116.630'], ['N04.761.700.350.650', 'N05.700.350.650'], ['Z01.107.56... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Recombinant early secreted antigen target 6 protein as a skin test antigen for the specific detection of Mycobacterium tuberculosis infection. | Although the delayed-type hypersensitivity skin test reaction to tuberculin purified protein derivative (PPD) is used worldwide for tuberculosis (TB) detection, it is incapable of distinguishing Mycobacterium tuberculosis (MTB) infection from bacille Calmette-Gu?rin (BCG) vaccination or infection with non-tuberculous M... | ['Adult', 'Animals', 'Antigens, Bacterial', 'Bacterial Proteins', 'Dose-Response Relationship, Immunologic', 'Female', 'Guinea Pigs', 'Humans', 'Hypersensitivity, Delayed', 'Male', 'Middle Aged', 'Mycobacterium', 'Recombinant Proteins', 'Sensitivity and Specificity', 'Skin Tests', 'Tuberculin Test', 'Tuberculosis'] | 18,321,349 | [['M01.060.116'], ['B01.050'], ['D23.050.161'], ['D12.776.097'], ['G12.300'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.418'], ['M01.060.116.630'], ['B03.510.024.962.500', 'B03.510.460.400.410.552.552'], ['D12.776.828'], ['E05.318.370.800', 'E05.318.740.872', 'G17.8... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. | Pathogen persistence after clinical cure is a hallmark of many chronic infections. Previously, we showed that naturally occurring CD4+CD25+ regulatory T (nTreg) cells rapidly accumulate within chronic dermal sites of Leishmania major infection where they suppress anti-pathogen CD4+ T cell responses, favor parasite pers... | ['Animals', 'Chemotaxis, Leukocyte', 'Leishmania major', 'Leishmaniasis, Cutaneous', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Receptors, CCR5', 'T-Lymphocytes, Regulatory'] | 17,015,634 | [['B01.050'], ['G04.198.424.233'], ['B01.268.475.868.488.405'], ['C01.610.752.300.500.400', 'C01.610.858.560.400', 'C01.920.813.400', 'C17.800.838.775.560.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiotensin II AT(2) receptor inhibits smooth muscle cell migration via fibronectin cell production and binding. | To explore the vascular function of the angiotensin II (ANG II) AT(2) receptor subtype (AT(2)R), we generated a vascular smooth muscle cell (SMC) line expressing the AT(2)R (SMC-vAT(2)). The involvement of AT(2)R in the motility response of SMCs was examined in SMC-vAT(2) cells and their controls (SMC-v) cultured on ei... | ['Animals', 'Cell Adhesion', 'Cell Movement', 'Cells, Cultured', 'Cytoskeleton', 'Extracellular Matrix Proteins', 'Fibronectins', 'Gene Expression', 'Gene Transfer Techniques', 'Humans', 'Iodine Radioisotopes', 'Laminin', 'Muscle, Smooth, Vascular', 'Rats', 'Receptor, Angiotensin, Type 2', 'Receptors, Angiotensin', 'Re... | 11,880,254 | [['B01.050'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['A11.251'], ['A11.284.430.214.190.750'], ['D12.776.860.300'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['G05.297'], ['E05.393.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microscale synthesis of nitrogen-13-labeled cisplatin. | A microscale synthesis of [13N]cisplatin (cis-dichlorodiammineplatinum(II), cis-DDP) from cyclotron-produced [13N]ammonia is presented. Temperature, reaction time, ratios, and concentration of reactants have been optimized for each step of the synthesis. Purification is performed by ion exchange chromatography. Radioch... | ['Ammonia', 'Chromatography, High Pressure Liquid', 'Chromatography, Thin Layer', 'Cisplatin', 'Isotope Labeling', 'Microchemistry', 'Nitrogen Radioisotopes', 'Quality Control'] | 3,712,059 | [['D01.362.075', 'D01.625.050'], ['E05.196.181.400.300'], ['E05.196.181.400.537'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E05.522'], ['E05.196.620', 'H01.181.650'], ['D01.268.604.500.520', 'D01.362.625.500.520', 'D01.496.586.520', 'D01.496.749.615'], ['J01.897.608']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
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