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The effect of various therapeutic trials on the prophyrin excretion in a case of congenital erythropoietic prophyria. | A patient with a biochemically "new" type of congenital erythropoietic porphyria has been studied under various therapeutic trials. Splenectomy had no demonstrable effect on porphyrin excretion or clinical picture. Vitamin E caused a moderate fall in porphyrin excretion, however, there was no significant improvement in... | ['Blood Transfusion', 'Bone Marrow Diseases', 'Carotenoids', 'Child, Preschool', 'Erythrocytes', 'Erythropoiesis', 'Humans', 'Infant', 'Male', 'Photosensitivity Disorders', 'Porphyrias', 'Porphyrins', 'Splenectomy', 'Syndrome', 'Vitamin E'] | 1,130,187 | [['E02.095.135'], ['C15.378.190'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['M01.060.406.448'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G04.152.825.414', 'G09.188.343.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C17.800... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Murine myeloid leukemia: in vivo suppression by sericystatin A, a proteinase inhibitor from leukocytes. | Parenteral administration of sericystatin A, an intracellular leukocyte inhibitor of the proinsulin-splitting enzyme cathepsin B, prolongs the mean survival time of mice with insulin-dependent myeloid leukemia. Sericystatin A reduces the supranormal blood levels of substances detectable by insulin-specific radioimmunoa... | ['Animals', 'Cells, Cultured', 'Cystatin A', 'Cystatins', 'Insulin', 'Leukemia, Experimental', 'Leukemia, Myeloid', 'Male', 'Mice', 'Mice, Inbred Strains', 'Protease Inhibitors', 'Proteins', 'Spleen', 'Thymidine'] | 6,343,090 | [['B01.050'], ['A11.251'], ['D12.776.215.100'], ['D12.776.215'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C04.557.337.372', 'C04.619.531', 'E05.598.500.496.500'], ['C04.557.337.539'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in the chondrocytes of patients with osteoarthritis. | The main pathogenic events in osteoarthritis (OA) include loss and abnormal remodeling of cartilage extracellular matrix. The present study aimed to evaluate the protective effect of tauroursodeoxycholic acid on chondrocyte apoptosis induced by endoplasmic reticulum (ER) stress. Articular cartilage tissues were collect... | ['Adolescent', 'Adult', 'Aged', 'Caspase 12', 'Cells, Cultured', 'Chondrocytes', 'Endoplasmic Reticulum Stress', 'Female', 'Gene Expression Regulation', 'Heat-Shock Proteins', 'Humans', 'Male', 'Middle Aged', 'Osteoarthritis', 'Taurochenodeoxycholic Acid', 'Transcription Factor CHOP', 'Tunicamycin'] | 26,238,983 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.277.656.262.500.126.550.920', 'D08.811.277.656.300.200.126.550.920', 'D12.644.360.075.405.550.920', 'D12.776.476.075.405.550.920'], ['A11.251'], ['A11.329.171'], ['G04.434'], ['G05.308'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A robust sampling approach for identification and quantification of methyl jasmonate in leaf tissue of oilseed rape for analysis of early signaling in Sclerotinia sclerotiorum resistance. | INTRODUCTION: Methyl jasmonate (MJA), which is a natrual hormonal regulator, is thought to be essential for the regulation of systemic defence responses. The information about MJA levels in plant tissues is helpful for the study of the disease resistance mechanism and genetically engineered cultivars with increased res... | ['Acetates', 'Ascomycota', 'Brassica rapa', 'Chromatography, Gas', 'Cyclopentanes', 'Host-Pathogen Interactions', 'Immunity, Innate', 'Methanol', 'Microscopy, Electron, Scanning', 'Oxylipins', 'Plant Diseases', 'Plant Extracts', 'Plant Leaves', 'Reproducibility of Results', 'Signal Transduction', 'Temperature'] | 20,020,434 | [['D02.241.081.018', 'D10.251.400.045'], ['B01.300.107'], ['B01.650.940.800.575.912.250.157.200.277'], ['E05.196.181.349'], ['D02.455.426.392.368.450'], ['G06.462', 'G16.527.200'], ['G12.450.564'], ['D02.033.623'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D10.251.355.645'], ['G15.610'], ['D20.215.784.500', 'D2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Research roundup. | Synopses of a selection of recently published research articles of relevance to palliative care. | ['Adult', 'Aged', 'Aged, 80 and over', 'Attitude of Health Personnel', 'Biomedical Research', 'Critical Care Nursing', 'Female', 'Hospice and Palliative Care Nursing', 'Humans', 'Intensive Care, Neonatal', 'Male', 'Middle Aged', 'Nursing Staff, Hospital', 'Palliative Care', 'Resilience, Psychological', 'United Kingdom'... | 31,339,823 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.050', 'N05.300.100'], ['H01.770.644.145'], ['H02.478.676.175', 'N02.421.533.149'], ['H02.478.676.350', 'N02.421.533.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.190.405', 'N02.421.585.190.500'], ['M01.060.116.630'], ['M01.526... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Nurses's knowledge of heart failure education principles. | OBJECTIVE: The goal of this study was to determine nurses' knowledge of heart failure (HF) self-management education principles.DESIGN: The study was exploratory and descriptive and included a convenience sample.SETTING: Research took place in a large midwestern health care system that included a university-based hospi... | ['Adult', 'Analysis of Variance', 'Clinical Competence', 'Data Collection', 'Education, Nursing', 'Female', 'Health Knowledge, Attitudes, Practice', 'Heart Failure', 'Humans', 'Male', 'Ohio', 'Probability', 'Self Care', 'Surveys and Questionnaires'] | 11,910,385 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['I02.358.462'], ['F01.100.150.500', 'N05.300.150.410'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Adjusting for differential-verification bias in diagnostic-accuracy studies: a Bayesian approach. | In studies of diagnostic accuracy, the performance of an index test is assessed by verifying its results against those of a reference standard. If verification of index-test results by the preferred reference standard can be performed only in a subset of subjects, an alternative reference test could be given to the rem... | ['Bayes Theorem', 'Bias', 'Diagnostic Techniques and Procedures', 'Humans', 'Models, Statistical', 'Reference Standards', 'Sensitivity and Specificity'] | 21,228,702 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['N05.715.350.150', 'N06.850.490.500'], ['E01.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05.978.808'], ['E05.318.370.800', 'E05.318.740.872', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The prevalence of glaucoma in patients with sleep apnea syndrome: same as in the general population. | PURPOSE: An association of glaucoma and sleep apnea syndrome (SAS) has been widely reported. We investigated the largest group of patients with SAS thus far to determine the prevalence of glaucoma among these patients.DESIGN: Cross-sectional study.METHODS: An institutional study.STUDY POPULATION: A total of 228 patient... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cross-Sectional Studies', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Israel', 'Male', 'Middle Aged', 'Optic Disk', 'Prevalence', 'Sleep Apnea Syndromes', 'Visual Fields'] | 14,644,220 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['Z01.252.245.500.375'], ['M01.060.116.630'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A Heuristic Algorithm for Identifying Molecular Signatures in Cancer. | Molecular signatures of cancer, e.g., genes or microRNAs (miRNAs), have been recognized very important in predicting the occurrence of cancer. From gene-expression and miRNA-expression data, the challenge of identifying molecular signatures lies in the huge number of molecules compared to the small number of samples. T... | ['Algorithms', 'Computational Biology', 'Heuristics', 'Humans', 'MicroRNAs', 'Neoplasms'] | 31,352,348 | [['G17.035', 'L01.224.050'], ['H01.158.273.180', 'L01.313.124'], ['F02.463.425.725.500', 'F02.463.785.810.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['C04']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution. | Laccase catalyses the oxidation of a variety of organic substrates coupled to the reduction of oxygen to water. It is widely believed to be the simplest representative of the ubiquitous blue multi-copper oxidase family. Laccase is implicated in a wide spectrum of biological activities and, in particular, plays a key ro... | ['Amino Acid Sequence', 'Ascorbate Oxidase', 'Azurin', 'Binding Sites', 'Copper', 'Coprinus', 'Crystallography, X-Ray', 'Humans', 'Laccase', 'Molecular Sequence Data', 'Oxidoreductases', 'Protein Conformation', 'Protein Structure, Secondary', 'Recombinant Proteins'] | 9,546,223 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.682.180'], ['D12.776.097.100', 'D12.776.556.080'], ['G02.111.570.120'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.300.179.100.200'], ['E05.196.309.742.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.494'], ['L01.453.245.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
PCB's in fish from selected waters of New York State. | PCB residues in fish from 41 stations throughout New York State were monitored in 1975. Nearly all fish contained PCB's in detectable amounts although the levels of contamination and specific Aroclor varied. The Hudson River contained the highest known PCB concentrations within the United States; levels often exceeded ... | ['Animals', 'Aroclors', 'Fishes', 'Fresh Water', 'New York', 'Plankton', 'Polychlorinated Biphenyls', 'Shellfish'] | 414,199 | [['B01.050'], ['D02.309.750.500', 'D02.455.526.439.773.292', 'D02.455.526.439.785.292'], ['B01.050.150.900.493'], ['G16.500.275.280', 'N06.230.232'], ['Z01.107.567.875.075.437', 'Z01.107.567.875.350.530', 'Z01.107.567.875.500.530'], ['B05.080.500'], ['D02.309.750', 'D02.455.426.559.389.185.698', 'D02.455.526.439.773'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Patients with diabetes respond well to contingency management treatment targeting alcohol and substance use. | Alcohol and drug use contribute to the pathogenesis of diabetes and are associated with adverse health outcomes, but little research exists on treatments for substance use disorders (SUDs) in patients with diabetes. The aim of this study was to evaluate contingency management (CM) treatments targeting substance use in ... | ['Adult', 'Alcohol-Related Disorders', 'Behavior Therapy', 'Diabetes Mellitus', 'Female', 'Humans', 'Male', 'Middle Aged', 'Substance-Related Disorders', 'Treatment Outcome'] | 25,531,935 | [['M01.060.116'], ['C25.775.100', 'F03.900.100'], ['F04.754.137'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C25.775', 'F03.900'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. | RATIONALE: Serotonin-1B receptor (5-HT1BR) agonist treatment induces obsessive-compulsive disorder (OCD)-like behaviors including locomotor stereotypy, prepulse inhibition deficits, and delayed alternation disruptions, which are selectively prevented by clinically effective OCD treatment. However, the role of 5-HT1BRs ... | ['Animals', 'Corpus Striatum', 'Desipramine', 'Exploratory Behavior', 'Female', 'Fluoxetine', 'Indoles', 'Mice', 'Mice, Inbred C57BL', 'Obsessive-Compulsive Disorder', 'Receptor, Serotonin, 5-HT1B', 'Serotonin 5-HT1 Receptor Agonists', 'Serotonin 5-HT1 Receptor Antagonists', 'Serotonin Receptor Agonists', 'Stereotyped ... | 26,423,528 | [['B01.050'], ['A08.186.211.200.885.287.249.487'], ['D03.633.300.240.281'], ['F01.145.387', 'F01.658.370'], ['D02.092.831.280'], ['D03.633.100.473'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['F03.080.600'], ['D12.776.543.750.670.80... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Challenging communication: people with learning disabilities who challenge services. | This paper describes a project designed to equip direct care workers with the knowledge and skills to address communication as a central factor in the lives of people with learning disabilities who challenge services. The elements of the approach taken--'Challenging Communication'--are described, outcomes discussed and... | ['Caregivers', 'Communication', 'Humans', 'Learning Disabilities', 'Models, Educational', 'Program Evaluation', 'Social Behavior Disorders'] | 10,343,730 | [['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.150.550', 'C23.888.592.604.150.550', 'F03.625.562'], ['E05.599.545', 'I02.903.302'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['I01.880.735.784']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Clemontanoside-C, a saponin from Clematis montana. | Clemontanoside-C, a new hederagenin-based saponin isolated from the stems of Clematis montana, was identified by chemical and spectroscopic methods as hederagenin-3-O-alpha-L-arabinopyranosyl (1-3)-alpha-L-rhamnopyranosyl (1-2)-alpha-L-arabinopyranoside. | ['Carbohydrate Sequence', 'Magnetic Resonance Spectroscopy', 'Molecular Sequence Data', 'Molecular Structure', 'Oleanolic Acid', 'Plants', 'Saponins', 'Triterpenes'] | 7,763,801 | [['G02.111.570.160', 'L01.453.245.667.160'], ['E05.196.867.519'], ['L01.453.245.667'], ['G02.111.570', 'G02.466'], ['D02.455.849.919.530.733', 'D02.455.849.919.650.600'], ['B01.650'], ['D09.408.782'], ['D02.455.849.919']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Classifying health-related behaviours: exploring similarities and differences amongst behaviours. | OBJECTIVES: The classification of health behaviours may provide a useful framework for understanding their characteristics and therefore the ways in which they are similar and different. However, to date, little research has attempted to identify these characteristics and explore the dimensions along which behaviours d... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'England', 'Feeding Behavior', 'Female', 'Focus Groups', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Health Surveys', 'Humans', 'Interview, Psychological', 'Life Style', 'Male', 'Mass Screening', 'Middle Aged', 'Motivation', 'Sunscreening Agents', 'Young Adul... | 19,646,330 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['Z01.542.363.300'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Quantitation of intrinsic magnetic susceptibility-related effects in a tissue matrix. Phantom study. | A theoretical background and experimental method that allows a separation of intrinsic, tissue-matrix-specific magnetic-field inhomogeneity effects from both macroscopic (large compared with voxel dimensions) and microscopic (on the order of molecular dimensions) inhomogeneities is proposed. Such separation allows one ... | ['Algorithms', 'Blood Volume', 'Bone and Bones', 'Cerebrovascular Circulation', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Magnetics', 'Models, Theoretical', 'Oxygen', 'Oxygen Consumption', 'Phantoms, Imaging', 'Polyethylenes', 'Surface Properties'] | 9,498,598 | [['G17.035', 'L01.224.050'], ['G09.188.130', 'G09.330.380.092'], ['A02.835.232', 'A10.165.265'], ['G09.330.100.159'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['H01.671.493'], ['E05.599'], ['D01.268.185.550', 'D01.362.670'], ['G03.680'], ['E07.671'], ['D02.455.326.271.6... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Differential induction of Pax genes by NGF and BDNF in cerebellar primary cultures. | The Pax genes encode sequence-specific DNA binding transcription factors that are expressed in embryonic development of the nervous system. Primary neuronal cell cultures derived from the cerebellar cortex of embryonic day 14, newborn and 7-d old mice, were used to investigate the cell-type specific expression patterns... | ['Animals', 'Base Sequence', 'Brain-Derived Neurotrophic Factor', 'Cells, Cultured', 'Cerebellum', 'DNA', 'DNA-Binding Proteins', 'Eye Proteins', 'Gene Expression Regulation', 'Homeodomain Proteins', 'Mice', 'Molecular Sequence Data', 'Multigene Family', 'Nerve Growth Factors', 'Nerve Tissue Proteins', 'Neurons', 'Orga... | 8,163,557 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['A11.251'], ['A08.186.211.132.810.428.200'], ['D13.444.308'], ['D12.776.260'], ['D12.776.306'], ['G05.308'], ['D12.776.260.400'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Aspects of nasopharyngeal microflora and middle ear function in children]. | Exudative otitis media (EOM) was detected in 13 (14.8%) children out of 88 preschool children at audiological investigation. In their nasopharynx, these children carried pneumococci and hemophylic bacilli. The latter were identified 1.7 times more often in children with EOM than in those free of it. Both pathogens were... | ['Child, Preschool', 'Female', 'Haemophilus Infections', 'Humans', 'Male', 'Nasopharynx', 'Otitis Media with Effusion', 'Pneumococcal Infections'] | 11,011,576 | [['M01.060.406.448'], ['C01.150.252.400.700.433'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.623.557', 'A14.724.557'], ['C09.218.705.663.670'], ['C01.150.252.410.890.670']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adjunctive techniques to improve access of the endoscopic prelacrimal recess approach. | OBJECTIVES: To determine whether adjunctive surgical techniques could improve access of instruments provided by the endoscopic prelacrimal recess approach to the anatomical boundaries of the maxillary sinus, and pterygopalatine and infratemporal fossa.METHODS: Ten fresh-frozen adult cadaver heads were utilized. The ana... | ['Anatomic Landmarks', 'Cadaver', 'Endoscopy', 'Humans', 'Maxillary Sinus', 'Palate, Hard', 'Skull'] | 31,487,048 | [['A01.111'], ['C23.550.260.224'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.531.621.578'], ['A02.835.232.781.324.502.660', 'A14.521.658.660', 'A14.549.617.660'], ['A02.835.232.781']] | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Investigation of the leaching behavior of lead in stabilized/solidified waste using a two-year semi-dynamic leaching test. | Long-term leaching behavior of contaminant from stabilization/solidification (S/S) treated waste stays unclear. For the purpose of studying long-term leaching behavior and leaching mechanism of lead from cement stabilized soil under different pH environment, semi-dynamic leaching test was extended to two years to inves... | ['Acids', 'Construction Materials', 'Diffusion', 'Hydrogen-Ion Concentration', 'Lead', 'Models, Statistical', 'Refuse Disposal', 'Soil', 'Soil Pollutants', 'Time Factors'] | 27,681,255 | [['D01.029'], ['J01.637.241'], ['G01.202', 'G02.196'], ['G02.300'], ['D01.268.556.435', 'D01.552.544.435'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.88... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Carotid artery revascularization in patients with contralateral carotid artery occlusion: Stent or endarterectomy? | BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) considers that contralateral carotid artery occlusion puts the patients at high risk for carotid endarterectomy (CEA) and agrees to reimburse for carotid artery stenting (CAS) in these patients. However, there is a paucity of evidence that support the sup... | ['Aged', 'Carotid Stenosis', 'Chi-Square Distribution', 'Endarterectomy, Carotid', 'Endovascular Procedures', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Proportional Hazards Models', 'Registries', 'Retrospective Studies', 'Risk Factors'... | 28,666,824 | [['M01.060.116.100'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E04.100.814.456.250'], ['E04.100.814.529', 'E04.502.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650',... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
High capacity for tissue-type plasminogen activator release from vascular endothelium in vivo. | BACKGROUND: Tissue-type plasminogen activator (t-PA) is the key mediator of intravascular fibrinolysis. We showed recently that local administrations both of methacholine (MCH) and of desmopressin (1-desamino-8-D-arginine vasopressin, DDAVP) induced a massive local release of t-PA in the human forearm vasculature.OBJEC... | ['Adult', 'Blood Flow Velocity', 'Deamino Arginine Vasopressin', 'Endothelium, Vascular', 'Forearm', 'Humans', 'Hypoglycemic Agents', 'Infusions, Intra-Arterial', 'Male', 'Methacholine Chloride', 'Muscarinic Agonists', 'Plethysmography', 'Tissue Plasminogen Activator', 'Vasoconstriction'] | 9,488,216 | [['M01.060.116'], ['E01.370.370.130', 'G09.330.380.630.080'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456.925.100.250', 'D12.644.548.691.692.781.100.250', 'D12.776.631.650.937.100.250'], ['A07.015.700.500', 'A10.272.491.355'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo. | High scalability of a novel bicyclic nucleoside building block, amido-bridged nucleic acid (AmNA), to diversify pharmacokinetic properties of therapeutic antisense oligonucleotides is described. N2'-functionalization of AmNA with a variety of hydrophobic groups is straightforward. Combinations of these modules display ... | ['Amines', 'Animals', 'Apolipoprotein C-III', 'Drug Delivery Systems', 'Enzyme-Linked Immunosorbent Assay', 'Hydrophobic and Hydrophilic Interactions', 'Liver', 'Mice', 'Oligonucleotides, Antisense', 'Organophosphorus Compounds', 'RNA, Messenger'] | 25,690,587 | [['D02.092'], ['B01.050'], ['D10.532.091.400.875', 'D12.776.070.400.400.875', 'D12.776.521.120.400.875'], ['E02.319.300'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G02.409'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['D13.150... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Turning the tide on medical errors in intensive care units: a human factors approach. | Errors occur in all nursing settings. The current healthcare climate tends to focus on individuals as the cause of errors rather than addressing issues that may be inherently wrong with the healthcare system that predisposes the individual to make errors. Human factors engineering (HFE), which is focused on removing hu... | ['Critical Care', 'Delivery of Health Care', 'Ergonomics', 'Humans', 'Intensive Care Units', 'Medical Errors', 'Medication Systems, Hospital', 'Nursing', 'Safety Management', 'Systems Analysis'] | 15,273,483 | [['E02.760.190', 'N02.421.585.190'], ['N04.590.374', 'N05.300'], ['F02.784.412', 'J01.293.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['N02.421.450'], ['N04.452.442.452.675', 'N04.452.528.473'], ['H02.478', 'N04.452.758.377'], ['N04.452.871.900', 'N06.850.135.060.075.800'], ['L01.906']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Spermatogenesis in XO,Sxr mice: role of the Y chromosome. | The goal of this investigation was to evaluate the role of the Y chromosome in spermatogenesis by a quantitative and qualitative analysis of spermatogenesis as it occurs in the absence of a significant portion of the Y chromosome, i.e., in XO,Sxr male mice. Although these mice have the testis-determining portion of the... | ['Animals', 'Isoenzymes', 'Kinetics', 'L-Lactate Dehydrogenase', 'Male', 'Mice', 'Mice, Inbred ICR', 'Mice, Mutant Strains', 'Multigene Family', 'Nuclear Proteins', 'Spermatids', 'Spermatogenesis', 'Testis', 'Translocation, Genetic', 'X Chromosome', 'Y Chromosome'] | 2,401,885 | [['B01.050'], ['D08.811.348', 'D12.776.800.300'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['B01.050.150.900.649.313.992.635.505.500.550'], ['G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcome after prenatal and postnatal diagnosis of complex congenital heart defects and the influence of genetic anomalies. | OBJECTIVE: Determine prenatal detection rate, mortality and association with genetic abnormalities in patients with severe CHD.METHOD: Single center retrospective study in patients with severe CHD diagnosed prenatally or postnatally (2006 to 2014).RESULTS: A total of 567 patients were included, 176 (31%) after prenatal... | ['Abortion, Induced', 'Belgium', 'Congenital Abnormalities', 'Female', 'Fetal Death', 'Fetal Diseases', 'Heart Defects, Congenital', 'Humans', 'Infant, Newborn', 'Pregnancy', 'Prenatal Diagnosis', 'Prognosis', 'Retrospective Studies', 'Ultrasonography, Prenatal'] | 28,727,893 | [['E04.520.050'], ['Z01.542.115'], ['C16.131'], ['C13.703.223', 'C23.550.260.585'], ['C13.703.277', 'C16.300'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769'], ['E01.370.378.630'], ['E01.789'], ['E05.318.372.500.500.500', 'E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Introducing a novel mechanism to control heart rate in the ancestral Pacific hagfish. | Although neural modulation of heart rate is well established among chordate animals, the Pacific hagfish (Eptatretus stoutii) lacks any cardiac innervation, yet it can increase its heart rate from the steady, depressed heart rate seen in prolonged anoxia to almost double its normal normoxic heart rate, an almost fourfo... | ['Adenylyl Cyclases', 'Animals', 'Cell Membrane', 'Cyclic AMP', 'Female', 'Hagfishes', 'Heart Rate', 'Hypoxia', 'Male', 'Myocardium', 'Receptors, Adrenergic, beta', 'Sodium-Bicarbonate Symporters', 'Solubility'] | 27,510,962 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['A11.284.149'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['B01.050.150.200.400.380', 'B01.050.150.900.493.516', 'B01.050.500.272.400.380'], ['E01.370.600.875.500', 'G09.330.380.500'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of cordarone on the eye (results of long-term follow-up of the treatment and prevention of arrhythmia)]. | Thirty-one patients who received a prolonged maintenance therapy with cordarone to treat and prevent cardiac arrhythmias underwent an ophthalmologic examination. The treatment lasted 1.5 to 51 months. The signs of keratopathy were detected in 24 (77.4%) patients using a slit lamp biomicroscopy. There is a relationship ... | ['Adult', 'Aged', 'Amiodarone', 'Arrhythmias, Cardiac', 'Corneal Diseases', 'Dose-Response Relationship, Drug', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Time Factors'] | 3,226,044 | [['M01.060.116'], ['M01.060.116.100'], ['D03.633.100.127.075'], ['C14.280.067', 'C23.550.073'], ['C11.204'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.910.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Purification and structural elucidation of exoploysaccharide from a new marine bacterium Lentibacter algarum ZXM100T]. | Exopolysaccharide La0.1-1 was extracted from the broth of a marine bacterium Lentibacter algarum ZXM100T isolated from the seawater in the coastal region of Qingdao and purified by Q Sepharose Fast Flow ion-exchange chromatography and Superdex 75 gel-permeation chromatography. Its physiochemical properties and primary ... | ['Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Gas Chromatography-Mass Spectrometry', 'Magnetic Resonance Spectroscopy', 'Molecular Weight', 'Polysaccharides', 'Rhodobacteraceae', 'Seawater'] | 25,007,581 | [['E05.196.181.400.250'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['E05.196.181.349.500', 'E05.196.566.500'], ['E05.196.867.519'], ['G02.494'], ['D09.698'], ['B03.660.050.750'], ['G16.500.275.725.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. | The specification of the vertebrate body plan is dependent on numerous signaling molecules, including members of the Wnt family. We have identified two zebrafish wnt8 paralogs related to Xwnt-8B and Xwnt-8, respectively. A RT-PCR assay demonstrated that wnt8 is expressed maternally, with transcripts detected throughout... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cytoskeletal Proteins', 'DNA Primers', 'Embryonic Induction', 'Female', 'Gene Expression', 'In Situ Hybridization', 'Mesoderm', 'Molecular Sequence Data', 'Morphogenesis', 'Phenotype', 'Polymerase Chain Reaction', 'Proteins', 'Sequence Alignment', 'Wnt Proteins', 'Xe... | 7,600,994 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G04.085.300', 'G04.152.300', 'G07.345.500.100.250', 'G07.345.500.325.180.750', 'G08.686.784.170.104.750'], ['G05.297'], ['E0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. | Carfilzomib is a next-generation proteasome inhibitor that selectively and irreversibly binds to its target. In clinical studies, carfilzomib has shown efficacy in patients with relapsed and/or refractory multiple myeloma (MM) and has demonstrated a tolerable safety profile. In this phase 2, open-label, multicentre cli... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Boronic Acids', 'Bortezomib', 'Disease Progression', 'Drug Resistance, Neoplasm', 'Fatigue', 'Female', 'Gastrointestinal Neoplasms', 'Hematologic Diseases', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Oligopeptides', 'Protease Inhibitors', 'Pyrazines', 'Recurrence',... | 22,845,873 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['C23.550.291.656'], ['G07.690.773.984.395'], ['C23.888.369'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['C15.378'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical research in palliative care: choice of trial design. | Prospective controlled clinical trials provide the highest level of evidence in palliative care. Both parallel and crossover studies have unique advantages and disadvantages. Excellent knowledge of the patient population, interventions and endpoints are useful in choosing the most appropriate trial. Open pilot studies ... | ['Cross-Over Studies', 'Double-Blind Method', 'Humans', 'Palliative Care', 'Pilot Projects', 'Randomized Controlled Trials as Topic', 'Research Design', 'Statistics, Nonparametric'] | 11,407,200 | [['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Paroxysmal nocturnal haemoglobinuria in Thailand with special reference to as association with aplastic anaemia. | Eighty-five cases of PNH in Thailand were analysed, with emphasis on the comparison with European series and on an association with aplastic anaemia. Compared with European series, two points emerge: (1) the disease in Thai affects individuals of younger age group with a tendency to male preponderance; (2) the incidenc... | ['Age Factors', 'Anemia, Aplastic', 'Female', 'Hemoglobinuria, Paroxysmal', 'Humans', 'Male', 'Sex Factors', 'Thailand'] | 678,478 | [['N05.715.350.075', 'N06.850.490.250'], ['C15.378.071.085', 'C15.378.190.223.250'], ['C15.378.071.141.560', 'C15.378.190.625.460'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.715.350.675', 'N06.850.490.875'], ['Z01.252.145.841']] | ['Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Reconstruction of crashes involving injured child occupants: the risk of serious injuries associated with sub-optimal restraint use may be reduced by better controlling occupant kinematics. | OBJECTIVE: To determine whether injuries to sub-optimally restrained child occupants in real-world crashes were likely to be preventable by alternative restraint usage practices and to assess the usefulness of crash reconstruction for exploring injury mechanisms in child occupants.METHODS: Real-world crashes in which c... | ['Accidents, Traffic', 'Biomechanical Phenomena', 'Child', 'Child, Preschool', 'Equipment Safety', 'Humans', 'Infant Equipment', 'Models, Anatomic', 'Seat Belts', 'Trauma Severity Indices', 'Wounds and Injuries'] | 17,366,336 | [['N06.850.135.392'], ['G01.154.090', 'G01.374.089'], ['M01.060.406'], ['M01.060.406.448'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.490'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['E07.700.800'], ['E05.318.308.940.968.875', 'E05.944', 'N04.452.859.564.800', 'N05.715.360.300.7... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. | Electrophoretic separation of ribonucleoprotein particles in a nondenaturing gel was used to analyze the splicing of mRNA precursors. Early in the reaction, a complex formed consisting of the U2 small nuclear ribonucleoprotein particle (snRNP) bound to sequences upstream of the 3' splice site. This complex is modeled a... | ['HeLa Cells', 'Humans', 'Macromolecular Substances', 'Nucleic Acid Precursors', 'RNA Splicing', 'RNA, Messenger', 'RNA, Small Nuclear', 'Ribonucleoproteins', 'Ribonucleoproteins, Small Nuclear'] | 2,953,438 | [['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05'], ['D13.400'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.700'], ['D13.444.735.544'], ['D13.444.735.628.818', 'D13.444.735.790.552.937'], ['D12.776.157.725.500', 'D12.776.664.962.500'], ['D12.776... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of the Natural Product Marthiapeptide A. | The first total synthesis of marthiapeptide A is reported. Two synthetic procedures are described: the first, which was unsuccessful, attempts to close the ring at position I, and the second, which was successful, closes the ring at position II. It appears that the first route was unsuccessful because it required cycli... | ['Biological Products', 'Cyclization', 'Molecular Structure', 'Peptides, Cyclic', 'Thiazoles'] | 26,469,351 | [['D20.215'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['G02.111.570', 'G02.466'], ['D04.345.566', 'D12.644.641'], ['D02.886.675', 'D03.383.129.708']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stroke education using an animated cartoon and a manga for junior high school students. | BACKGROUND: We investigated whether junior high school students could be educated regarding stroke with an animated cartoon and a Manga that we produced for the purpose of dissemination of this knowledge.METHODS: We produced a 10-minute animated cartoon and a Manga that provided information regarding stroke risk factor... | ['Adolescent', 'Awareness', 'Cartoons as Topic', 'Child', 'Female', 'Health Education', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Schools', 'Stroke', 'Students', 'Surveys and Questionnaires'] | 24,680,086 | [['M01.060.057'], ['F02.463.188.150'], ['K01.093.206.332'], ['M01.060.406'], ['I02.233.332', 'N02.421.726.407'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.783', 'J03.832'], ['C10.228.140.300.775', 'C14.907.253.855'], ['M01.848'], ['E05.318.308.980', 'N05.715.360.300.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Identification and partial characterization of mesenchyme-derived growth factor that stimulates proliferation and inhibits functional differentiation of mouse mammary epithelium in culture. | The effect of mesenchyme on both proliferation and differentiation of mammary epithelial cells was investigated in a primary cell culture system. Mammary cells cultured on collagen gel for 4 days produced casein in response to the synergistic action of insulin, cortisol, and prolactin. When mammary epithelial cells wer... | ['Animals', 'Caseins', 'Cell Differentiation', 'Cell Division', 'Cells, Cultured', 'Chromatography, Gel', 'DNA', 'Epithelial Cells', 'ErbB Receptors', 'Female', 'Growth Substances', 'Mammary Glands, Animal', 'Mesoderm', 'Mice', 'Mice, Inbred C3H'] | 2,583,064 | [['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['E05.196.181.400.250'], ['D13.444.308'], ['A11.436'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['D2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and properties of biodegradable and chemically recyclable cationic surfactants containing carbonate linkages. | Novel biodegradable and chemically recyclable carbonate-type cationic surfactants consisting of a long chain alkyl group and a quaternary ammonium propyl group were designed and synthesized as a green surfactant. These carbonate-type cationics showed better surface activities in an aqueous solution when compared to the... | ['Anti-Infective Agents', 'Biodegradation, Environmental', 'Carbonates', 'Cations', 'Equipment Reuse', 'Molecular Structure', 'Surface-Active Agents'] | 17,898,517 | [['D27.505.954.122'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['D01.248.497.300'], ['E05.328', 'N06.850.585'], ['G02.111.570', 'G02.466'], ['D27.720.877']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A kinetic study of isoamyl acetate synthesis by immobilized lipase-catalyzed acetylation in n-hexane. | The objective of this work was to propose a reaction mechanism and to develop a rate equation for the synthesis of isoamyl acetate by acylation of the corresponding alcohol with acetic anhydride using the lipase Novozym 435 in n-hexane. The reaction between isoamyl alcohol and acetic anhydride occurred at high rate in ... | ['Acetic Acid', 'Acetic Anhydrides', 'Acetylation', 'Candida', 'Catalysis', 'Enzymes, Immobilized', 'Hexanes', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lipase', 'Pentanols', 'Substrate Specificity', 'Time Factors'] | 16,959,353 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['D02.113.075', 'D02.241.081.018.193'], ['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['G02.130'], ['D08.811.180', 'D12.776.463.500'], ['D02.455.326.146.500'], ['G02.300'], ['G01.374.661', 'G02.111.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of the Italian Version of the Neck Disability Index: cross-cultural adaptation, factor analysis, reliability, validity, and sensitivity to change. | STUDY DESIGN: Evaluation of the psychometric properties of a translated and culturally adapted questionnaire.OBJECTIVE: Translating, culturally adapting, and validating the Italian version of the Neck Disability Index (NDI-I) to allow its use with Italian-speaking patients with neck pain (NP).SUMMARY OF BACKGROUND DATA... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cross-Cultural Comparison', 'Disability Evaluation', 'Female', 'Humans', 'Italy', 'Language', 'Male', 'Middle Aged', 'Neck Pain', 'Pain Measurement', 'Psychometrics', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Severity of Illness Index', 'Surveys and Questionna... | 22,487,712 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['F01.145.209.399', 'L01.559'], ['M01.060.116.630'], ['C23.888.592.612.553'], ['E01.370.600.550.324'], ['F04.711.780'], ['E05... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Structural characterization and expression of a brain specific gene encoding chick kainate binding protein. | The gene encoding chick kainate-binding protein (c-KBP), a member of the non-NMDA ionotropic glutamate receptor family has been isolated and characterized. The c-KBP gene is at least 13 kilobases long and contains 11 exons interrupted by 10 introns. Primer extension and RNase protection studies identified a major trans... | ['Animals', 'Base Sequence', 'Brain', 'Cerebellum', 'Chickens', 'DNA', 'Exons', 'Gene Expression Regulation', 'Introns', 'Kainic Acid', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Organ Specificity', 'Receptors, Kainic Acid', 'Receptors, Neurotransmitter', 'Transcription, Genetic'] | 1,312,013 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['A08.186.211.132.810.428.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D13.444.308'], ['G05.360.340.024.340.137.232'], ['G05.308'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['D03.383.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Randomized Controlled Trial of Primary Health Care Strategies for the Promotion of Leisure-Time Physical Activity Among Older Brazilians. | BACKGROUND: Physical activity promotion within primary health care is in the spotlight. However, few studies have evaluated the long-term effectiveness of possible interventions. This study aimed to compare the effectiveness of 3 primary health care interventions in increasing leisure-time physical activity among older... | ['Aging', 'Brazil', 'Counseling', 'Exercise', 'Female', 'Health Promotion', 'Humans', 'Leisure Activities', 'Life Style', 'Male', 'Middle Aged', 'Primary Health Care', 'Referral and Consultation'] | 31,310,991 | [['G07.345.124'], ['Z01.107.757.176'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['G11.427.410.698.277', 'I03.350'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450'], ['F01.829.458'], ['M01.060.116.630'], ['N04.590.233.727'], ['N04.452.... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Trends in adolescent contraceptive use, unprotected and poorly protected sex, 1991-2003. | PURPOSE: To estimate trends in use and nonuse of effective protection among adolescents 1991-2003, and to assess factors associated with poorly protected sex in 2003.METHODS: We analyzed seven Youth Risk Behavior Surveys (YRBSs) of 9th-12th graders conducted from 1991 through 2003. We estimated trends in use of condoms... | ['Adolescent', 'Adolescent Behavior', 'Contraceptive Agents', 'Female', 'Health Surveys', 'Humans', 'Male', 'Pregnancy', 'Pregnancy in Adolescence', 'Retrospective Studies', 'Risk-Taking', 'Sexually Transmitted Diseases', 'Unsafe Sex'] | 16,730,603 | [['M01.060.057'], ['F01.145.022'], ['D27.505.696.875.360', 'D27.505.954.705.360'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['G08.686.784.769.494'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. | Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. To this end, we studie... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Cell Differentiation', 'Cyclin-Dependent Kinase 4', 'Female', 'Follow-Up Studies', 'Gene Amplification', 'Gene Dosage', 'Humans', 'In Situ Hybridization, Fluorescence', 'Liposarcoma', 'Male', 'Microarray Analysis', 'Middle Aged', 'Neoplasm Staging', 'Prognosi... | 29,153,098 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['G04.152'], ['D08.811.913.696.620.682.700.646.500.875', 'D12.644.360.250.451', 'D12.776.167.200.451', 'D12.776.476.250.451'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G05.308.250', 'G05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Etiology and clinical characteristics of pregnancy-emerged thrombocytopenia]. | OBJECTIVE: To investigate the etiology and clinical characteristics of pregnancy-emerged thrombocytopenia.METHODS: A retrospective analysis was conducted on clinical data of 159 pregnancies with thrombocytopenia, who were admitted to Peking University People's Hospital from January 2000 to January 2010. All the patient... | ['Anemia, Aplastic', 'Anemia, Hemolytic, Autoimmune', 'Cesarean Section', 'Delivery, Obstetric', 'Female', 'Glucocorticoids', 'HELLP Syndrome', 'Humans', 'Hypertension, Pregnancy-Induced', 'Infant, Newborn', 'Myelodysplastic Syndromes', 'Platelet Count', 'Postpartum Hemorrhage', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy... | 22,333,233 | [['C15.378.071.085', 'C15.378.190.223.250'], ['C15.378.071.141.125', 'C20.111.175'], ['E04.520.252.500'], ['E04.520.252'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['C13.703.395.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.395', 'C14.907.489.480'], ['M01.060.703.520'], ['C15.378.190.625'], [... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. | BACKGROUND: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spi... | ['Adult', 'Australia', 'Canada', 'Clinical Protocols', 'Female', 'Fetal Growth Retardation', 'Gestational Age', 'Humans', 'International Cooperation', 'Ireland', 'Netherlands', 'New Zealand', 'Pregnancy', 'Pregnancy Outcome', 'Prognosis', 'Sildenafil Citrate', 'Treatment Outcome', 'United Kingdom', 'Vasodilator Agents'... | 29,282,009 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['Z01.107.567.176'], ['E02.183', 'N05.715.360.330.125'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['Z01.542.467', 'Z01.639.587'], ['Z01.542.65... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Eyeing the eyes in social scenes: Evidence for top-down control of stimulus selection in simultanagnosia. | Simultanagnosia is a disorder of visual attention resulting from bilateral parieto-occipital lesions. Healthy individuals look at eyes to infer people's attentional states, but simultanagnosics allocate abnormally few fixations to eyes in scenes. It is unclear why simultanagnosics fail to fixate eyes, but it might refl... | ['Adult', 'Agnosia', 'Attention Deficit Disorder with Hyperactivity', 'Fixation, Ocular', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Neuropsychological Tests', 'Photic Stimulation', 'Posterior Leukoencephalopathy Syndrome', 'Social Perception', 'Visual Fields'] | 23,537,050 | [['M01.060.116'], ['C10.597.606.762.100', 'C23.888.592.604.764.100', 'F01.700.750.100'], ['F03.625.094.150'], ['G14.350.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['F04.711.513'], ['E05.723.729'], ['C10.228.140.631.500.500', 'C10.228.140.695.875'], ['F02.463.593.752'], ['F02.463.59... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Solid and papillary neoplasm of the pancreas. Emphasis on surgical treatment. | Six Chinese females with solid and papillary neoplasms of the pancreas underwent surgery. Mean age was 26 years. The most common clinical sign was a large palpable abdominal mass. One patient presented with shock and acute onset of abdominal pain with positive peritoneal signs due to rupture of the tumor. The surgical ... | ['Adolescent', 'Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Pancreatectomy', 'Pancreatic Neoplasms', 'Survival Rate', 'Treatment Outcome'] | 8,457,156 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.210.752'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E05.318.308.985.550.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Honesty when lighting votive candles in church: an informal look. | An informal enquiry conducted over 6 yr. suggested a decline from 92% to 28% of people paying for lighting votive candles in a large Catholic church. | ['Catholicism', 'Deception', 'Gift Giving', 'Humans', 'New England', 'Religion and Psychology'] | 15,362,428 | [['K01.844.188.250'], ['F01.145.813.157'], ['F01.145.813.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.550'], ['F02.880', 'K01.844.664']] | ['Humanities [K]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Prior short-term synaptic disinhibition facilitates long-term potentiation and suppresses long-term depression at CA1 hippocampal synapses. | Long-term potentiation (LTP) and long-term depression (LTD) are two main forms of activity-dependent synaptic plasticity that have been extensively studied as the putative mechanisms underlying learning and memory. Current studies have demonstrated that prior synaptic activity can influence the subsequent induction of ... | ['Adenine', 'Adenylyl Cyclase Inhibitors', 'Animals', 'Colforsin', 'Cyclic AMP', 'Electric Stimulation', 'Excitatory Postsynaptic Potentials', 'GABA-A Receptor Antagonists', 'Hippocampus', 'In Vitro Techniques', 'Long-Term Potentiation', 'Male', 'Picrotoxin', 'Piperidines', 'Pyramidal Cells', 'Rats', 'Rats, Sprague-Daw... | 10,583,494 | [['D03.633.100.759.138'], ['D27.505.519.389.108'], ['B01.050'], ['D02.455.849.291.300'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['E05.723.402'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Generation and characterization of a human osteosarcoma cell line stably transfected with the human estrogen receptor gene. | Although 17 beta-estradiol (E2) replacement therapy has been shown to be effective in treating postmenopausal osteoporosis, the underlying mechanism remains unclear. The presence of low levels of functional endogenous estrogen receptor (ER) in some osteoblastic cells has been demonstrated, and the suggestion that the a... | ['Alkaline Phosphatase', 'Base Sequence', 'Binding Sites', 'Blotting, Northern', 'Blotting, Southern', 'Bone Neoplasms', 'Breast Neoplasms', 'Cell Division', 'Chloramphenicol O-Acetyltransferase', 'Cloning, Molecular', 'DNA, Complementary', 'Gene Expression Regulation, Neoplastic', 'Genes, Reporter', 'Humans', 'Interle... | 7,639,112 | [['D08.811.277.352.650.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['C04.588.149', 'C05.116.231'], ['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Covariation of change in bioavailable testosterone and adiposity in midlife women. | OBJECTIVE: To determine whether menopause-related changes in reproductive hormones were associated with change in adiposity and whether these relationships were independent of important covariates.METHODS: Annual assessments of adiposity measures [computed tomography-assessed visceral adipose tissue (VAT) and subcutane... | ['Absorptiometry, Photon', 'Adiposity', 'Adult', 'Chicago', 'Ethnic Groups', 'Female', 'Follow-Up Studies', 'Humans', 'Intra-Abdominal Fat', 'Menopause', 'Middle Aged', 'Obesity', 'Population Surveillance', 'Prevalence', 'Retrospective Studies', 'Testosterone', 'Tomography, X-Ray Computed'] | 25,557,490 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['M01.686.754', 'N01.224.317'], ['E05.318.372.500.750.249', 'N05.715.360.330.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Isolation and characterization of trophoblast from murine placenta. | A discontinuous density gradient centrifugation method, devised to isolate enriched populations of trophoblast from murine definitive placentae, is described. It is concluded that the isolated adherent cells are trophoblast on the basis of the following characteristics: they are fetally derived, as determined by their ... | ['Animals', 'Cell Separation', 'Cells, Cultured', 'Centrifugation, Zonal', 'Embryo Transfer', 'Female', 'Fluorescent Antibody Technique', 'Glucose-6-Phosphate Isomerase', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Phagocytosis', 'Placenta', 'Povidone', 'Pregnancy', 'Receptors, Fc', 'Silicon ... | 3,018,719 | [['B01.050'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['E05.181.724.336.336', 'E05.196.941.336.419'], ['E02.875.800.500', 'E05.820.800.500'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D08.811... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Differences in Protein Expression between the U251 and U87 Cell Lines. | AIM: The U251 and U87 cell lines are commonly used as experimental models of glioblastoma. However, these cells exhibit significant differences in their proliferation, invasion, and migration. The aim of the present study was to compare the protein expression profiles of the U251 and U87 cell lines in order to provide ... | ['Brain Neoplasms', 'Cell Line, Tumor', 'Gene Expression Regulation, Neoplastic', 'Gene Ontology', 'Glioblastoma', 'Humans', 'Proteins', 'Signal Transduction'] | 27,651,343 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.308.370'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01.313.500.750.300.550.500.500', 'L01.453.245.945.079.500'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.6... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
CAPABILITIES OF THE ARADOS-WG03 REGIONAL NETWORK FOR LARGE-SCALE RADIOLOGICAL AND NUCLEAR EMERGENCY SITUATIONS IN ASIA. | In 2015, the Asian Radiation Dosimetry Group established a regional network of biological dosimetry laboratories known as the ARADOS-WG03 (Working Group 03; Biological Dosimetry). A survey was conducted in 2017 to evaluate the capabilities and capacities of the participating laboratories for emergency preparedness and ... | ['Asia', 'Biological Assay', 'Civil Defense', 'Cytogenetic Analysis', 'Disaster Planning', 'Expert Systems', 'Humans', 'Laboratories', 'Radiation Exposure', 'Radiation Protection', 'Radioactive Hazard Release', 'Radiometry'] | 30,576,530 | [['Z01.252'], ['E05.091'], ['I01.451.227'], ['E01.370.225.500.385', 'E05.200.500.385', 'E05.242.385', 'E05.393.285'], ['N06.230.100.035'], ['L01.224.050.375.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J03.520', 'N02.278.487'], ['G01.750.748', 'N06.850.460.350.850'], ['N06.850.810.425'], ['N06.850.135.848'... | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. | The recent decline in the effectiveness of some azole fungicides in controlling the wheat pathogen Mycosphaerella graminicola has been associated with mutations in the CYP51 gene encoding the azole target, the eburicol 14alpha-demethylase (CYP51), an essential enzyme of the ergosterol biosynthesis pathway. In this stud... | ['Antifungal Agents', 'Ascomycota', 'Azoles', 'Cytochrome P-450 Enzyme System', 'Drug Resistance, Fungal', 'Fungal Proteins', 'Gene Expression Profiling', 'Lanosterol', 'Sterol 14-Demethylase', 'Sterols', 'Triticum'] | 19,459,949 | [['D27.505.954.122.136'], ['B01.300.107'], ['D03.383.129'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G06.225.383', 'G07.690.773.984.269.383'], ['D12.776.354'], ['E05.393.332'], ['D02.455.849.919.383', 'D04.210.500.247.222.222.347.557', 'D04.210.500.247.808.607', 'D10.570.938.590'], ['D08.244... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Heart rate response profiles to tilting in healthy and unhealthy neonates. | BACKGROUND: Clinical observations suggest the immaturity of the neonate's ability to respond appropriately to cardio-respiratory challenges and tilt test could help in detecting autonomic dysfunction in neonates.MATERIAL/METHODS: Heart rate (HR) responses following a 45 degrees head-up tilt during sleep were measured w... | ['Bradycardia', 'Female', 'Heart Rate', 'Heroin Dependence', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Tilt-Table Test'] | 12,011,772 | [['C14.280.067.319', 'C23.550.073.300'], ['E01.370.600.875.500', 'G09.330.380.500'], ['C25.775.643.500.400', 'F03.900.647.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['E01.370.370.750']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Severity of Airflow Obstruction and Work Loss in a Nationwide Population of Working Age. | The impact of COPD severity on labor force participation and work loss is not well known. This study aimed to describe the characteristics of occupations and to evaluate the reason for work loss based on the severity of airflow obstruction (AO). We performed a cross-sectional study using data from the Korean National H... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Forced Expiratory Volume', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Nutrition Surveys', 'Pulmonary Disease, Chronic Obstructive', 'Spirometry', 'Vital Capacity'] | 29,946,117 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E05.318.308.980.485', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Luminescent photoproducts in UV-irradiated ice. | This Account describes the near-UV and visible luminescences emitted from crystalline, polycrystalline, and amorphous ices as a result of excitation by UV light. Vibrationally resolved, short-lived luminescence around 340 nm arises from excited O(2) formed by the reaction of two O atoms. Long-lived luminescence around ... | ['Ice', 'Luminescent Measurements', 'Ultraviolet Rays'] | 11,041,830 | [['D01.045.250.875.400', 'D01.248.497.158.459.650.400', 'D01.650.550.925.400', 'G16.500.275.410', 'G16.500.750.775.342', 'N06.230.291'], ['E05.196.712.516'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600', 'G16.500.750.775.52... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists. | A Hit-to-Lead optimisation programme was carried out on the adamantane high throughput screening hit 1 resulting in the discovery of a number of potent P2X(7) antagonists. | ['Adamantane', 'Amides', 'Drug Design', 'Humans', 'Kinetics', 'Purinergic P2 Receptor Antagonists', 'Receptors, Purinergic P2X7', 'Structure-Activity Relationship'] | 14,592,505 | [['D02.455.426.100.050', 'D02.455.426.392.368.075'], ['D02.065'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D27.505.519.625.725.400.200', 'D27.505.696.577.725.400.200'], ['D12.776.157.530.400.400.750.700', 'D12.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicting pathological fracture in femoral metastases using a clinical CT scan based algorithm: A case-control study. | BACKGROUND: We assessed whether there was a difference in attenuation measurements (in Hounsfield units - HU) and geometric distribution of HU between femora with metastatic lesions that fracture, and metastatic lesions that did not fracture nor underwent prophylactic fixation.METHODS: Nine patients with femoral metast... | ['Adult', 'Aged', 'Algorithms', 'Area Under Curve', 'Case-Control Studies', 'Female', 'Femoral Neoplasms', 'Fracture Fixation', 'Fracture Healing', 'Fractures, Spontaneous', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'ROC Curve', 'Reference Values', 'Retrospective Studies', 'Risk Assessment', 'Tomogr... | 29,128,112 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C04.588.149.276', 'C05.116.231.343'], ['E04.555.300'], ['G16.762.891.500'], ['C26.404.374'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis: a case report and review of the literature. | Hepatopulmonary syndrome (HPS) is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with fatigue, long-lasting fever, loss of weight, signs of portal hypertension, hepatosplenomegaly, cholestas... | ['Echocardiography', 'Granuloma', 'Hepatitis', 'Hepatopulmonary Syndrome', 'Humans', 'Male', 'Methylprednisolone', 'Middle Aged'] | 16,482,641 | [['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C15.604.515.292', 'C23.550.382'], ['C06.552.380'], ['C06.552.455', 'C08.381.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.432.769.795.539'], ['M01.060.116.630']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of synovial fluid neutrophil CD64 index as a screening biomarker of prosthetic joint infection. | AIMS: Prosthetic joint infection (PJI) remains a major clinical challenge. Neutrophil CD64 index, Fc-gamma receptor 1 (FcãR1), plays an important role in mediating inflammation of bacterial infections and therefore could be a valuable biomarker for PJI. The aim of this study is to compare the neutrophil CD64 index in s... | ['Arthroplasty, Replacement, Hip', 'Arthroplasty, Replacement, Knee', 'Biomarkers', 'Blood Sedimentation', 'C-Reactive Protein', 'Diagnosis, Differential', 'Female', 'Hip Prosthesis', 'Humans', 'Knee Prosthesis', 'Male', 'Neutrophils', 'Osteoarthritis, Hip', 'Osteoarthritis, Knee', 'Prospective Studies', 'Prosthesis Fa... | 32,228,083 | [['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['D23.101'], ['E01.370.225.625.125', 'E05.200.625.125'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E01.171'], ['E07.695.400.400'], ['B01.050.150.900.649.313.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Report of the Australian National Polio Reference Laboratory. 1 January 1999 to 30 June 1999. Towards WHO certification as wild poliovirus-free: laboratory surveillance in Australia. | Since 1994 the Australian National Polio Reference Laboratory at the Victorian Infectious Diseases Reference Laboratory has been responsible for virological confirmation of the eradication of poliomyelitis in Australia. The laboratory is also a World Health Organization Western Pacific regional polio reference laborato... | ['Acute Disease', 'Australia', 'Humans', 'Laboratories', 'Paralysis', 'Poliomyelitis', 'Poliovirus', 'Population Surveillance', 'World Health Organization'] | 10,615,795 | [['C23.550.291.125'], ['Z01.639.100', 'Z01.678.100.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J03.520', 'N02.278.487'], ['C10.597.622', 'C23.888.592.636'], ['C01.207.618.750', 'C01.925.782.687.359.764', 'C10.228.228.618.750', 'C10.228.854.525.850', 'C10.668.864'], ['B04.820.578.750.284.184.500'], ['E05.3... | ['Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance. | Current perspectives on clinical use of N-methyl-D-aspartate (NMDA) receptor antagonists infer acute and repeated administration schedules for management of different pathological states. Development of tolerance and cross-tolerance between different antagonists may significantly affect their clinical effectiveness. Si... | ['Animals', 'Central Nervous System Depressants', 'Drug Interactions', 'Drug Tolerance', 'Ethanol', 'Excitatory Amino Acid Antagonists', 'Male', 'Memantine', 'Mice', 'Motor Skills', 'Piperazines', 'Receptors, N-Methyl-D-Aspartate'] | 10,680,714 | [['B01.050'], ['D27.505.696.277', 'D27.505.954.427.210'], ['G07.690.773.968'], ['G07.690.773.992'], ['D02.033.375'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D02.455.426.100.050.035.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['F02.808.260'], ['D03.383.606'], ['D12.776.157.530.400.400.500.500',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Real time three-dimensional stress echocardiography: a new approach for assessing diastolic function. | OBJECTIVE: To assess the feasibility of utilizing real time three-dimensional echocardiography (RT3DE) for assessment of diastolic function during stress.METHODS: Rest and stress volumes were acquired in 24 patients and parameters of diastolic function-peak ventricular filling rate (PFR) and time to peak filling rate (... | ['Computer Systems', 'Echocardiography, Three-Dimensional', 'Exercise Test', 'Female', 'Humans', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Stroke Volume', 'Ventricular Dysfunction, Left', 'Ventricular Pressure'] | 21,718,353 | [['L01.224.230'], ['E01.370.350.130.750.230', 'E01.370.350.400.200', 'E01.370.350.850.220.230', 'E01.370.370.380.220.230'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Nitric oxide synthase is not expressed, nor up-regulated in response to cold acclimation in liver or muscle of threespine stickleback (Gasterosteus aculeatus). | There are three isoforms of the enzyme nitric oxide synthase (NOS) in mammals: endothelial NOS (eNOS), inducible NOS (iNOS) and neuronal NOS (nNOS). All three isoforms oxidize arginine to citrulline in a reaction producing nitric oxide (NO), which regulates multiple signaling pathways and physiological functions in mam... | ['Acclimatization', 'Animals', 'Arginase', 'Arginine', 'Brain', 'Carbon Radioisotopes', 'Cold Temperature', 'Enzyme Activation', 'Liver', 'Muscles', 'Nitric Oxide Synthase', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction', 'Smegmamorpha', 'Time Factors', 'Up-Regulation'] | 22,037,234 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['D08.811.277.913.292'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['A08.186.211'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', '... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review. | BACKGROUND: There is substantial variation in how menopausal vasomotor symptoms are reported and measured among intervention studies. This has prevented meaningful comparisons between treatments and limited data synthesis.OBJECTIVES: To review systematically the outcome reporting and measures used to assess menopausal ... | ['Female', 'Hot Flashes', 'Humans', 'Menopause', 'Outcome Assessment, Health Care', 'Randomized Controlled Trials as Topic', 'Vasomotor System'] | 31,621,155 | [['C23.888.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.157.500', 'G08.686.841.249.500'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['A08.800.050.800.900']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Reports of adolescent emotion regulation and school engagement mediating the relation between parenting and adolescent functioning in India. | Much like other parts of Asia, late adolescence in India is a particularly stressful time with academic pressures of a highly competitive examination system that determines future occupational success. The present study examined interrelations among reports of parenting, adolescents' regulation of academics-related emo... | ['Adolescent', 'Emotions', 'Female', 'Humans', 'India', 'Male', 'Negotiating', 'Parenting'] | 28,176,328 | [['M01.060.057'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['F01.145.209.520', 'F01.829.401.520', 'F02.463.785.373.520', 'L01.143.620', 'N04.452.677.430'], ['F01.829.263.370.310']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
[Myocardial contractility in newborn kittens under a physiologic loading regimen]. | The angles of ramp of normalized dependences: "strength-velocity" and "terminal systolic length--terminal systolic strength" proved to be lesser under physiological loads in isolated papillary muscles of newborn kitten as compared with adult cats. Adrenaline increased the slope of these dependences up to the values cha... | ['Animals', 'Animals, Newborn', 'Cats', 'Electric Stimulation', 'Epinephrine', 'In Vitro Techniques', 'Myocardial Contraction', 'Papillary Muscles'] | 3,215,331 | [['B01.050'], ['B01.050.050.282'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['E05.481'], ['G09.330.580', 'G11.427.494.570'], ['A02.633.580.680', 'A07.541.510.619', 'A... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of 5,7-dihydroxytryptamine lesions of the nucleus accumbens on rat intravenous morphine self-administration. | The role of serotonergic innervations of the nucleus accumbens in the processes maintaining intravenous morphine self-administration were assessed. Pairs of male rat littermates were implanted with intravenous jugular catheters and bilateral injection guide cannulae into the central medial nucleus accumbens, made physi... | ['5,7-Dihydroxytryptamine', 'Animals', 'Brain', 'Catecholamines', 'Dihydroxytryptamines', 'Dose-Response Relationship, Drug', 'Infusions, Intravenous', 'Male', 'Morphine', 'Nucleus Accumbens', 'Rats', 'Rats, Inbred F344', 'Self Administration', 'Septal Nuclei'] | 3,575,377 | [['D03.633.100.473.914.201.263'], ['B01.050'], ['A08.186.211'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['D03.633.100.473.914.201'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1â, IL-23, and TNF-like 1A expression by monocytes. | The nervous system influences immune responses through the release of neural factors such as neuropeptides. Among them, the tachykinin substance P (SP) signals via the neurokinin 1 receptor (NK-1R), which is expressed by various immune cells. We thereby analyzed in this paper whether tachykinins may participate in huma... | ['Cell Communication', 'Cell Differentiation', 'Cell Polarity', 'Cells, Cultured', 'Humans', 'Immunologic Memory', 'Inflammation Mediators', 'Interleukin-1beta', 'Interleukin-23', 'Monocytes', 'Substance P', 'Tachykinins', 'Th17 Cells', 'Tumor Necrosis Factor Ligand Superfamily Member 15'] | 21,368,235 | [['G04.085'], ['G04.152'], ['G04.250'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.500'], ['D23.469'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D12.776.467.374.465.010.600', 'D12.776.467.374.500.400.600', 'D23.529.374.465.131.600', 'D23.529.374.500.400.600'], ['D1... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Decrease in Mycobacterium ulcerans disease (Buruli ulcer) in the Lalo District of B?nin (West Africa). | BACKGROUND: Buruli ulcer (BU) is a chronic, necrotizing infectious skin disease caused by Mycobacterium ulcerans. In recent years, there has been a decrease in the number of new cases detected. This study aimed to show the evolution of its distribution in the Lalo District in B?nin from 2006 to 2017.METHODS: The databa... | ['Adult', 'Benin', 'Buruli Ulcer', 'Female', 'Humans', 'Male', 'Middle Aged', 'Mycobacterium ulcerans', 'Polymerase Chain Reaction', 'Prevalence'] | 30,871,489 | [['M01.060.116'], ['Z01.058.290.190.200'], ['C01.150.252.410.040.552.475.247', 'C17.800.893.295'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['B03.510.024.962.500.720.700', 'B03.510.460.400.410.552.552.720.700'], ['E05.393.620.500'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.85... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes. | OBJECTIVES: We sought to examine trends in the use and outcomes of transmyocardial revascularization (TMR) in community practice. We also identified important risk factors for TMR and compared outcomes of TMR combined with coronary artery bypass graft surgery (TMR + CABG) versus bypass alone in patients receiving incom... | ['Aged', 'Controlled Clinical Trials as Topic', 'Coronary Artery Bypass', 'Female', 'Humans', 'Laser Therapy', 'Logistic Models', 'Male', 'Middle Aged', 'Multicenter Studies as Topic', 'Myocardial Revascularization', "Practice Patterns, Physicians'", 'Registries', 'Risk Factors', 'Treatment Outcome'] | 14,607,448 | [['M01.060.116.100'], ['E05.318.372.250.250.365', 'N05.715.360.330.250.250.365', 'N06.850.520.450.250.250.365'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Progressive multifocal leukoencephalopathy: JC virus detection by in situ hybridization compared with immunohistochemistry. | In four cases of progressive multifocal leukoencephalopathy (PML), we compared biotin-labeled DNA:DNA in situ hybridization with peroxidase immunohistochemistry for the detection of JC virus (JCV). The localization of JCV DNA and JCV capsid protein was compared in formalin-fixed, paraffin-embedded brain tissues. Infect... | ['Adolescent', 'Antigens, Viral', 'Astrocytes', 'Brain', 'Cerebellum', 'DNA, Viral', 'Humans', 'Immunochemistry', 'Leukoencephalopathy, Progressive Multifocal', 'Male', 'Middle Aged', 'Oligodendroglia', 'Polyomavirus', 'Tumor Virus Infections'] | 3,008,027 | [['M01.060.057'], ['D23.050.327'], ['A08.637.200', 'A11.650.200'], ['A08.186.211'], ['A08.186.211.132.810.428.200'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.486', 'H01.181.122.605', 'H02.403.044.500'], ['C01.207.245.340.500', 'C01.207.399.750.500', 'C01.925.182.525.500', 'C01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Acquired interventricular communication and false left ventricular aneurysm caused by non-penetrating trauma of the thorax]. | A 48 year old man, victim of a serious road traffic accident (multiple limb fractures, closed trauma of the left hemithorax) was immediately diagnosed as having a systolic regurgitant murmur. The initial ECG recordings showed anterior subepicardial ischemia, and later, a low antero-septal and apical infarction. The hem... | ['Diagnosis, Differential', 'Electrocardiography', 'Heart Aneurysm', 'Heart Injuries', 'Heart Septal Defects, Ventricular', 'Heart Septum', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged', 'Radiography', 'Wounds, Nonpenetrating'] | 6,414,417 | [['E01.171'], ['E01.370.370.380.240', 'E01.370.405.240'], ['C14.280.358', 'C14.907.055.608'], ['C26.891.375'], ['C14.240.400.560.540', 'C14.280.400.560.540', 'C16.131.240.400.560.540'], ['A07.541.459'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['C26.974... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evidence for an obligatory intermediate in the folding of interleukin-1 beta. | The folding of the beta-sheet protein, interleukin-1 beta, was examined at pH 5.0 and 25 degrees C using pulse-labelling hydrogen exchange and electrospray ionization mass spectrometric analysis, as well as stopped-flow circular dichroism and fluorescence spectroscopies. The first detectable event is the formation of a... | ['Interleukin-1', 'Kinetics', 'Mass Spectrometry', 'Protein Folding'] | 9,303,000 | [['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['G01.374.661', 'G02.111.490'], ['E05.196.566'], ['G01.154.651', 'G02.111.688']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Perceived stigma in Spasmodic Torticollis. | Little is known about the "stigmatizing" effects of Spasmodic Torticollis--a condition that produces physical disfigurement. This is important in understanding the social dimensions of this disorder. This study examined the presence, the dimensions, and the degree of perceived stigma in patients with Spasmodic Torticol... | ['Aged', 'Attitude to Health', 'Female', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Self Concept', 'Stereotyping', 'Surveys and Questionnaires', 'Torticollis'] | 11,295,781 | [['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['F01.752.747.792'], ['F01.100.920', 'F01.145.813.854'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['C23.888.592... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Selection of higher order regression models in the analysis of multi-factorial transcription data. | INTRODUCTION: Many studies examine gene expression data that has been obtained under the influence of multiple factors, such as genetic background, environmental conditions, or exposure to diseases. The interplay of multiple factors may lead to effect modification and confounding. Higher order linear regression models ... | ['Animals', 'Binding Sites', 'Gene Expression Profiling', 'Linear Models', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Oligonucleotide Array Sequence Analysis', 'Regression Analysis', 'Transcription Factors', 'Yersinia Infections'] | 24,658,540 | [['B01.050'], ['G02.111.570.120'], ['E05.393.332'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Low dose imaging of scoliosis: use of a computed radiographic imaging system. | A digital radiographic system using the technology of laser stimulated luminescence has been utilized for the evaluation of scoliosis at reduced exposure levels. A total of 412 examinations have been performed on children with scoliosis. Diagnostic images were produced at significantly reduced radiation exposures when ... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Lasers', 'Luminescent Measurements', 'Radiation Dosage', 'Radiographic Image Enhancement', 'Scoliosis', 'Tomography, X-Ray Computed'] | 2,602,023 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490', 'E07.710.520'], ['E05.196.712.516'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['C05.116.900.800.875'], ['E01.370.3... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Down-regulation of murine Cyp1a-1 in mouse hepatoma Hepa-1c1c7 cells by bisphenol A. | Cultured mouse hepatoma Hepa-1c1c7 cells were treated with either bisphenol A or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or in combination to assess the role of bisphenol A in the process of Cyp1a-1 induction. Treatment of Hepa-1c1c7 cultures with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induced Cyp1a-1, as deter... | ['Animals', 'Benzhydryl Compounds', 'Carcinoma, Hepatocellular', 'Cytochrome P-450 CYP1A1', 'Down-Regulation', 'Estrogens, Non-Steroidal', 'Liver Neoplasms', 'Mice', 'Phenols', 'Tumor Cells, Cultured'] | 11,061,999 | [['B01.050'], ['D02.455.426.559.389.115'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453.100.500'], ['G02.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prediction of severe bacterial infection in children with an emergency department diagnosis of infection. | OBJECTIVE: To determine the relationship between near-patient-test (NPT) lactate, white blood cell count (WBC) and C-reactive protein (CRP) and severe bacterial infection (SBI) in children presenting to the emergency department (ED) with infection.METHODS: An observational cohort study was undertaken in a paediatric em... | ['Area Under Curve', 'Bacterial Infections', 'Biomarkers', 'C-Reactive Protein', 'Child, Preschool', 'Cohort Studies', 'Emergency Service, Hospital', 'Female', 'Hospitals, Teaching', 'Hospitals, Urban', 'Humans', 'Lactic Acid', 'Leukocyte Count', 'Male', 'Predictive Value of Tests', 'Sensitivity and Specificity'] | 20,971,726 | [['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['C01.150.252'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N02.278.216.500.968.336', 'N02.421.297.195... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The social construction of illness experience: families with a chronically-ill child. | This paper examines how parents constructed the illness of a child with chronic sickness. The focus is on eliciting the parents' explanatory model of illness, that is, how they understood and described their child's illness, and how they managed their interactions with the child. The data were collected by using an eth... | ['Adaptation, Psychological', 'Adult', 'Child', 'Child, Preschool', 'Chronic Disease', 'Female', 'Humans', 'Interpersonal Relations', 'Life Style', 'Male', 'Parent-Child Relations', 'Parents'] | 6,915,046 | [['F01.058'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.829.458'], ['F01.829.263.370.290'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Iron-catalyzed synthesis of polysubstituted pyrroles via [4C+1N] cyclization of 4-acetylenic ketones with primary amines. | A highly efficient iron-catalyzed approach to polysubstituted pyrroles has been developed through the [4C+1N] cyclization of 4-acetylenic ketones with primary amines, leading to the synthesis of a variety of tetra- and fully-substituted pyrroles as well as fused pyrrole derivatives in good to excellent yields. | ['Alkynes', 'Amines', 'Catalysis', 'Cyclization', 'Iron', 'Ketones', 'Pyrroles'] | 21,072,395 | [['D02.455.326.397'], ['D02.092'], ['G02.130'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D02.522'], ['D03.383.129.578']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low grip strength is associated with bone mineral density and vertebral fracture in women. | OBJECTIVES: Grip strength has been reported to be associated with bone mass locally at the forearm and also at distant skeletal sites, including the spine and hip. Less is known about the association between low grip strength and risk of vertebral fracture. The aim of this study was to examine the association between l... | ['Absorptiometry, Photon', 'Aged', 'Body Size', 'Bone Density', 'Female', 'Femur', 'Hand Strength', 'Humans', 'Male', 'Middle Aged', 'Osteoporosis', 'Osteoporosis, Postmenopausal', 'Physical Exertion', 'Spinal Fractures', 'Spine'] | 15,728,415 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116.100'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['G11.427.100'], ['A02.835.232.043.150'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.11... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Post-operative blood pressure management by nitroglycerin in the field of neurosurgery]. | It is well known that vasodilating antihypertensive drugs induce intracranial hypertension. A considerable number of papers have reported nitroglycerin-induced ICP elevation during anesthetized operations. However, except for Gagnon's report, most papers dealt with normal patients. Our study, using an extradural pressu... | ['Adult', 'Aged', 'Antihypertensive Agents', 'Blood Pressure', 'Brain Diseases', 'Female', 'Humans', 'Hypertension', 'Intracranial Pressure', 'Male', 'Middle Aged', 'Nitroglycerin', 'Postoperative Care', 'Postoperative Complications', 'Pseudotumor Cerebri'] | 2,515,460 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C10.228.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['G11.561.170.505'], ['M01.060.116.630'], ['D02.640.636'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['C23.550.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptional and physiological analyses of Fe deficiency response in maize reveal the presence of Strategy I components and Fe/P interactions. | BACKGROUND: Under limited iron (Fe) availability maize, a Strategy II plant, improves Fe acquisition through the release of phytosiderophores (PS) into the rhizosphere and the subsequent uptake of Fe-PS complexes into root cells. Occurrence of Strategy-I-like components and interactions with phosphorous (P) nutrition h... | ['Ferric Compounds', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Iron', 'Phenotype', 'Phosphates', 'Plant Roots', 'Solubility', 'Transcriptome', 'Zea mays'] | 28,193,158 | [['D01.490.100'], ['E05.393.332'], ['G05.308.375'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['G05.695'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['A18.400'], ['G02.805'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920'], ['B01.650.940.800.575.912.250.822.966']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The implementation and efficacy of the Northwestern High Risk Spine Protocol. | OBJECTIVE: The aims of this study were to determine the efficacy and feasibility of implementation of the intraoperative component of a high risk spine (HRS) protocol for improving perioperative patient safety in complex spine fusion surgery.METHODS: In this paired availability study, the total number of red blood cell... | ['Adult', 'Aged', 'Blood Transfusion', 'Clinical Protocols', 'Female', 'Fluid Therapy', 'Hemostasis', 'Humans', 'Interdisciplinary Communication', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Oxygen Inhalation Therapy', 'Perioperative Period', 'Risk', 'Spine', 'Treatment Outcome'] | 24,947,117 | [['M01.060.116'], ['M01.060.116.100'], ['E02.095.135'], ['E02.183', 'N05.715.360.330.125'], ['E02.319.360'], ['G09.188.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['M01.060.116.630'], ['E04.525'], ['E02.880.690'], ['E04.614', 'N02.421.585.753'], ['E05.318.740.600.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
S100 Calcium Binding Protein A9 Represses Angiogenic Activity and Aggravates Osteonecrosis of the Femoral Head. | Ischemic damage aggravation of femoral head collapse is a prominent pathologic feature of osteonecrosis of the femoral head (ONFH). In this regard, S100 calcium binding protein A9 (S100A9) is known to deteriorate joint integrity, however, little is understood about which role S100A9 may play in ONFH. In this study, a p... | ['Adult', 'Aged', 'Animals', 'Calgranulin B', 'Case-Control Studies', 'Female', 'Femur Head Necrosis', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Hyperbaric Oxygenation', 'Male', 'Middle Aged', 'Proteomics', 'Rats', 'Up-Regulation'] | 31,752,076 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['D12.776.157.125.750.500.200', 'D12.776.631.655.500.200', 'D23.050.301.562.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C05.116.852.175', 'C23.550.717.732.368'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. | Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transiently opens the BBB, we ... | ['Animals', 'Antineoplastic Agents', 'Biological Transport', 'Blood-Brain Barrier', 'Brain', 'Dogs', 'Doxorubicin', 'Drug Delivery Systems', 'Female', 'Fever', 'Liposomes', 'Male', 'Nanoparticles', 'Temperature'] | 29,688,083 | [['B01.050'], ['D27.505.954.248'], ['G03.143'], ['A07.035', 'A08.186.211.035'], ['A08.186.211'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E02.319.300'], ['C23.888.119.344'], ['D25.479.517', 'D26.255.260.517', 'J01.637.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
MRI features of a solid mass-like renal lymphangioma: case report. | Renal lymphangioma typically manifests as a unilocular or multilocular cystic mass in the parapelvic or perirenal spaces. A solid mass-like lymphangioma rarely occurs and thus is hard to differentiate from a renal cell carcinoma. We encountered a case of a solid mass-like renal lymphangioma that was confirmed using per... | ['Biopsy, Needle', 'Carcinoma, Renal Cell', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Humans', 'Immunohistochemistry', 'Kidney Neoplasms', 'Lymphangioma', 'Magnetic Resonance Imaging', 'Middle Aged', 'Monitoring, Physiologic', 'Rare Diseases', 'Time Factors', 'Tomography, X-Ray Computed', 'Ultrasonogra... | 22,726,984 | [['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Low dose detection of ã radiation via solvent assisted fluorescence quenching. | Development of low cost, easy-to-use chemical sensor systems for low dose detection of ã radiation remains highly desired for medical radiation therapy and nuclear security monitoring. We report herein on a new fluorescence sensor molecule, 4,4'-di(1H-phenanthro[9,10-d]imidazol-2-yl)biphenyl (DPI-BP), which can be diss... | ['Biphenyl Compounds', 'Fluorescence', 'Fluorescent Dyes', 'Gamma Rays', 'Halogenation', 'Limit of Detection', 'Radiometry', 'Solvents', 'Spectrometry, Fluorescence'] | 24,611,651 | [['D02.455.426.559.389.185'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['G02.111.323', 'G03.360'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.799'], ['D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Lipid composition of serum lipoprotein in opisthorchiasis. | Lipid composition (i.e. total cholesterol, free cholesterol, cholesteryl ester, triglycerides and phospholipids) in the individual serum lipoprotein fractions (i.e. high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein) were studied in 24 healthy controls and 18 opisthorchiasis patients adm... | ['Adolescent', 'Adult', 'Aged', 'Cholesterol', 'Cholesterol Esters', 'Female', 'Humans', 'Lipoproteins', 'Lipoproteins, HDL', 'Male', 'Middle Aged', 'Opisthorchiasis', 'Phospholipids', 'Triglycerides'] | 3,250,339 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532', 'D12.776.521'], ['D10.532.432', 'D12.776.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Utility of HbA1c in the detection of subclinical post renal transplant diabetes. | BACKGROUND: We hypothesized that the use of HbA1c testing would help identify postrenal transplant diabetes (PTDM).METHODS: In all, 199 adult kidney transplant recipients at least 3 months posttransplant without previous history of diabetes or elevated fasting blood sugar were studied. Medical history, a fasting blood ... | ['Adolescent', 'Adult', 'Aged', 'Diabetes Mellitus', 'Early Diagnosis', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Kidney Transplantation', 'Male', 'Middle Aged'] | 16,477,224 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C18.452.394.750', 'C19.246'], ['E01.390'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. | We determined whether bimatoprost, which has been reported to act via putative prostamide receptors, could be hydrolyzed to its free acid (17-phenyl-PGF(2 alpha)), a potent FP receptor agonist, by human ocular tissue in vitro. We developed a gas chromatography/mass spectrometric method to measure 17-phenyl-PGF(2 alpha)... | ['Amides', 'Animals', 'Bimatoprost', 'Ciliary Body', 'Cloprostenol', 'Cornea', 'Dinoprost', 'Eye', 'Humans', 'Hydrolysis', 'In Vitro Techniques', 'Iris', 'Kinetics', 'Lipid Metabolism', 'Lipids', 'Prodrugs', 'Sclera', 'Swine', 'Time Factors'] | 12,648,303 | [['D02.065'], ['B01.050'], ['D02.065.141', 'D10.251.355.255.550.775.500.175.250', 'D23.469.050.175.725.775.500.175.250', 'D23.469.700.670.175.250'], ['A09.371.060.160', 'A09.371.894.280'], ['D10.251.355.255.550.775.500.175', 'D23.469.050.175.725.775.500.175', 'D23.469.700.670.175'], ['A09.371.060.217'], ['D10.251.355.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
N-methyl d-aspartate receptors are involved in the induction, but not expression stage of amphetamine sensitization in schedule-induced polydipsia in rats. | 1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and glu... | ['Animals', 'Dextroamphetamine', 'Dizocilpine Maleate', 'Excitatory Amino Acid Antagonists', 'Haloperidol', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, N-Methyl-D-Aspartate', 'Thirst'] | 20,557,320 | [['B01.050'], ['D02.092.471.683.152.110.200'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D02.522.352.506'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.157.530.400.400.500.500', 'D12.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants. | Keratinocytes play an important role in skin irritation. In an attempt to investigate mechanistic bases of human skin irritation response, we recently identified the upregulation by skin irritants of adipose differentiation related protein (ADRP) in reconstituted human epidermis. ADRP is a lipid-storage-droplet-associa... | ['Calcium', 'Cell Line', 'Humans', 'Irritants', 'Keratinocytes', 'L-Lactate Dehydrogenase', 'Lipid Metabolism', 'Membrane Proteins', 'Perilipin-2', 'Protein Kinases', 'Skin', 'Sodium Dodecyl Sulfate'] | 12,880,426 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.400', 'D27.888.569.300'], ['A11.409.500', 'A11.436.397'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['G03.458'], ['D12.776.543'], ['D12.776.157.464.500.750'], ['D08.811.913.6... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective Use of Anticoagulation or Dual Antiplatelet Therapy for Patients with Extra-anatomic Bypasses. | BACKGROUND: The benefit of long-term anticoagulation or dual antiplatelet therapy (DAPT) for patients with extra-anatomic bypasses to the lower extremity remains poorly defined. Our study analyzed the real-world use of antithrombotic therapy in patients with extra-anatomic bypass grafts to the lower extremity and compa... | ['Aged', 'Amputation', 'Anticoagulants', 'Blood Vessel Prosthesis Implantation', 'Clinical Decision-Making', 'Dual Anti-Platelet Therapy', 'Female', 'Fibrinolytic Agents', 'Humans', 'Limb Salvage', 'Lower Extremity', 'Male', 'Middle Aged', 'Peripheral Arterial Disease', 'Platelet Aggregation Inhibitors', 'Postoperative... | 31,931,126 | [['M01.060.116.100'], ['E04.555.080'], ['D27.505.954.502.119'], ['E04.100.814.868.500', 'E04.650.200'], ['E01.055'], ['E02.319.310.537'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.100.814.603', 'E04.555.400', 'E04.680.350'], ['A01.378.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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