Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Effects of polyethylene glycol and hydroxyethyl starch in University of Wisconsin preservation solution on human red blood cell aggregation and viscosity. | University of Wisconsin (UW) preservation solution is considered an effective flush and cold storage liquid. However, recent studies have provided evidence of the hyperaggregating effect on human red blood cells (RBC) of hydroxyethyl starch (HES), one of the components of the UW solution. In contrast, preservation solu... | ['Adenosine', 'Allopurinol', 'Blood Viscosity', 'Erythrocyte Aggregation', 'Erythrocyte Deformability', 'Glutathione', 'Humans', 'Hydroxyethyl Starch Derivatives', 'Insulin', 'Organ Preservation Solutions', 'Polyethylene Glycols', 'Potassium', 'Raffinose', 'Shear Strength', 'Sodium', 'Stress, Mechanical'] | 16,797,270 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D03.633.100.759.160'], ['G09.188.370.124', 'G09.330.380.630.110'], ['E01.370.225.625.225', 'E05.200.625.225', 'G09.188.370.187'], ['G09.188.370.249'], ['D12.644.456.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.301.915.500', 'D09.698.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[A case of renal cell carcinoma extending into renal vein in an 18-year-old male]. | An 18-year-old male was admitted to our hospital because of massive gross hematuria. Ultrasound and computerized tomographic (CT) scan revealed a solid left intrarenal mass with renal pelvic invasion and tumor thrombus in the left renal vein. Radical nephrectomy with intravenous tumor thrombectomy was performed. The le... | ['Adolescent', 'Carcinoma, Renal Cell', 'Humans', 'Kidney Neoplasms', 'Male', 'Neoplasm Invasiveness', 'Neoplastic Cells, Circulating', 'Renal Veins'] | 8,379,475 | [['M01.060.057'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synthesis and release of erythroid colony- and burst-potentiating activities by purified populations of murine peritoneal macrophages. | We investigated the effects of murine resident peritoneal macrophages on the in vitro proliferation of erythropoietin (Ep)-sensitive committed precursors colony-forming unit-erythroid (CFU-E) and burst-forming unit-erythroid (BFU-E) with a two-layer cloning system of methylcellulose and semisolid agar. The addition of ... | ['Animals', 'Ascitic Fluid', 'Cell Adhesion', 'Cell Separation', 'Cells, Cultured', 'Colony-Forming Units Assay', 'Drug Synergism', 'Erythropoiesis', 'Erythropoietin', 'Female', 'Indomethacin', 'Lymphocytes', 'Macrophages', 'Mice'] | 7,373,218 | [['B01.050'], ['A12.207.119'], ['G04.022'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['G07.690.773.968.477'], ['G04.152.825.414', 'G09.188.343.414'], ['D12.644.276.374.410.240.150', 'D12.776.395.240.150', 'D12.776.467.374.410.240.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel mutation of HOXA11 in a patient with septate uterus. | BACKGROUND: The etiology of M?llerian duct anomalies (MDAs) is poorly understood at present. The HOXA11 gene is crucial for the development of the M?llerian duct. The objective of this study is to report a unique case of MDAs with a novel mutation in HOXA11.RESULTS: We identified a potential disease-causing mutation (p... | ['Adult', 'Amino Acid Sequence', 'Asian Continental Ancestry Group', 'Cohort Studies', 'Female', 'HeLa Cells', 'Homeodomain Proteins', 'Humans', 'Mutation', 'Uterus'] | 29,229,001 | [['M01.060.116'], ['G02.111.570.060', 'L01.453.245.667.060'], ['M01.686.508.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['A05.36... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Regulation of cellulolytic genes by McmA, the SRF-MADS box protein in Aspergillus nidulans. | Cellobiose triggers the production of two endoglucanases, EglA and EglB, in Aspergillus nidulans. The cellulose responsive element (CeRE) cis-element that is essential for induction has been identified on the eglA promoter, but transcription factors that bind to CeRE have not yet been identified. CeRE contained a conse... | ['Amino Acid Sequence', 'Aspergillus nidulans', 'Base Sequence', 'Cellulase', 'Cellulose', 'Fungal Proteins', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Fungal', 'MADS Domain Proteins', 'Molecular Sequence Data', 'Mutation', 'Response Elements'] | 23,337,500 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.300.381.081.420'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.450.420.200.200'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['D12.776.354'], ['G05.308.320'], ['G05.308.330'], ['D12.776.260.400... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
QT effects of duloxetine at supratherapeutic doses: a placebo and positive controlled study. | BACKGROUND: The electrophysiological effects of duloxetine at supratherapeutic exposures were evaluated to ensure compliance with regulatory criteria and to assess the QT prolongation potential.METHODS: Electrocardiograms were collected in a multicenter, double-blind, randomized, placebo-controlled, crossover study tha... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Anti-Infective Agents', 'Antidepressive Agents', 'Aza Compounds', 'Cross-Over Studies', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Duloxetine Hydrochloride', 'Electrocardiography', 'Female', 'Fluoroquinolones', 'Guideline Adherence', 'Humans', 'Middle Age... | 17,414,226 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D27.505.954.122'], ['D27.505.954.427.700.122'], ['D02.145'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.32... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Whole-genome sequencing reveals selection signatures associated with important traits in six goat breeds. | Comparative population genomics analysis is an effective approach to identify selection signatures in farm animals. In this study, we systematically investigated the selection signatures in six phenotypically diverse goat breeds using SNPs obtained from pooled whole-genome resequencing data. More than 95.5% of 446-642 ... | ['Animals', 'Breeding', 'Genetics, Population', 'Genome', 'Genotype', 'Goats', 'Heterozygote', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Selection, Genetic', 'Whole Genome Sequencing'] | 29,991,772 | [['B01.050'], ['E05.820.150', 'G05.090'], ['H01.158.273.343.335'], ['G05.360.340'], ['G05.380'], ['B01.050.150.900.649.313.500.380.513'], ['G05.380.383'], ['G05.695'], ['G05.365.795.598'], ['G05.783'], ['E05.393.760.700.825']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. | The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, we genotyped three single-nucleotide polymorphisms (SNPs) in the CH... | ['Adolescent', 'Adult', 'Child', 'Chromosomes, Human, Pair 7', 'Female', 'Genetic Variation', 'Genetics, Population', 'Humans', 'Intelligence', 'Male', 'Middle Aged', 'Netherlands', 'Pedigree', 'Polymorphism, Single Nucleotide', 'Receptor, Muscarinic M2', 'Twins, Dizygotic', 'Twins, Monozygotic'] | 17,081,262 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['A11.284.187.520.300.325.335', 'G05.360.162.520.300.325.335'], ['G05.365'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['M01.060.116.630'], ['Z01.542.651'], ['E05.393.673'], ['G05.365.795.598'], ['D12.776.543.750.695.47... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
Does morphological convergence imply functional similarity? A test using the evolution of quadrupedalism in ornithischian dinosaurs. | Convergent morphologies are thought to indicate functional similarity, arising because of a limited number of evolutionary or developmental pathways. Extant taxa displaying convergent morphologies are used as analogues to assess function in extinct taxa with similar characteristics. However, functional studies of extan... | ['Animals', 'Biological Evolution', 'Biomechanical Phenomena', 'Dinosaurs', 'Fossils', 'Locomotion', 'Muscle, Skeletal', 'Phylogeny', 'Posture'] | 22,719,033 | [['B01.050'], ['G05.045', 'G16.075'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.833.150'], ['I01.076.368.584.311'], ['G07.568.500', 'G11.427.410.568'], ['A02.633.567', 'A10.690.552.500'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G11.427.695']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Free testosterone levels, attentional control, and processing speed performance in aging men. | Psychometric measures of processing speed are strong predictors of cognitive functioning with aging; however, the neurobiological mechanisms underlying this association remain unclear. Recently, the authors reported a negative association between calculated free testosterone levels (cEFT) and processing speed in men ag... | ['Adult', 'Age Factors', 'Aged', 'Aging', 'Analysis of Variance', 'Attention', 'Choice Behavior', 'Humans', 'Immunoenzyme Techniques', 'Intelligence Tests', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Normal Distribution', 'Predictive Value of Tests', 'Problem Solving', 'Reaction Time', 'Sex Hormone-Binding Glo... | 19,254,089 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['G07.345.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.830.104.214'], ['F02.463.785.373.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['F... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sensitive and robust LC-MS/MS analysis of digoxin in human plasma through optimization of in-source adduct formation. | AIM: To develop and validate an LC-MS/MS assay for the quantification of digoxin in human plasma. An LLOQ of 10 pg/ml using a 100 ìl sample was required to support drug-drug interactions studies.RESULTS: Digoxin formed multiple precursor ions in positive and negative ESI and methods based on several of these have been ... | ['Analytic Sample Preparation Methods', 'Blood Chemical Analysis', 'Calibration', 'Chromatography, Liquid', 'Digoxin', 'Humans', 'Limit of Detection', 'Linear Models', 'Sodium', 'Tandem Mass Spectrometry'] | 30,182,747 | [['E05.196.059'], ['E01.370.225.124.100', 'E05.200.124.100'], ['E05.978.155'], ['E05.196.181.400'], ['D04.210.500.155.580.130.500.436', 'D04.210.500.155.580.130.688', 'D09.408.180.261.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model. | Clearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of the gamma-carboxy glutamic acid (Gla) domain and the sialic acid content of the protein on rFVIIa clearance were investigated ... | ['Animals', 'Asialoglycoprotein Receptor', 'Asialoglycoproteins', 'Coagulants', 'Factor VIIa', 'Glycosylation', 'Half-Life', 'Humans', 'Injections, Intravenous', 'Liver', 'Male', 'Metabolic Clearance Rate', 'Orosomucoid', 'Peptide Fragments', 'Perfusion', 'Rats', 'Rats, Sprague-Dawley', 'Recombinant Proteins'] | 20,508,904 | [['B01.050'], ['D12.776.503.280.124', 'D12.776.543.750.024'], ['D12.776.395.140'], ['D27.505.954.502.270'], ['D08.811.277.656.300.760.300', 'D08.811.277.656.959.350.300', 'D12.776.124.125.325.300', 'D23.119.325.300'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Significance of elevated serum thyrotropin during treatment of congenital hypothyroidism. | Serum thyrotropin concentrations are frequently elevated during treatment of children with congenital hypothyroidism. It is unclear if elevated thyrotropin during early treatment indicates non-optimal treatment. In a cohort of 49 children with congenital hypothyroidism, we studied the decline in serum thyrotropin conce... | ['Cohort Studies', 'Congenital Hypothyroidism', 'Female', 'Humans', 'Hypothyroidism', 'Infant, Newborn', 'Male', 'Patient Compliance', 'Thyrotropin', 'Thyroxine'] | 7,670,245 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C05.116.099.343.347', 'C05.116.132.256', 'C16.320.240.625', 'C19.297.155', 'C19.874.482.281'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.482'], ['M01.060.703.520'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased expression of highly branched N-glycans at cell surface is correlated with the malignant phenotypes of mouse tumor cells. | Three NIH3T3 transformants, MTAg, MTPy, and MT1, which grow similarly in soft agar media, showed remarkable differences in athymic mice: MTAg grew more rapidly than MTPy, whereas MT1 and NIH3T3 did not, and only MTAg metastasized in lung. Structural analysis of N-glycans from plasma membrane glycoproteins revealed that... | ['3T3 Cells', 'Animals', 'Carbohydrate Sequence', 'Cell Transformation, Neoplastic', 'Glycosylation', 'Lectins', 'Lung Neoplasms', 'Membrane Glycoproteins', 'Mice', 'Molecular Sequence Data', 'Molecular Weight', 'Neoplasm Proteins', 'Neoplasm Transplantation', 'Neoplasms, Experimental', 'Phenotype', 'Plant Lectins', 'P... | 9,067,274 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['G02.111.570.160', 'L01.453.245.667.160'], ['C04.697.098.500', 'C23.550.727.098.500'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D12.776.503'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D12.776.395.550', 'D12.776.543.550'], ['B01.050.150.9... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Influence of aquatic microbiota on the survival in water of the human and eel pathogen Vibrio vulnificus serovar E. | The eel and human pathogen Vibrio vulnificus serovar E (biotype 2) is seldom isolated from natural waters, although it can survive in sterilized artificial seawater microcosms for years. The main objective of the present study was to investigate whether aquatic microbiota can limit its survival and recovery from water ... | ['Animals', 'Ecosystem', 'Eels', 'Humans', 'Seawater', 'Time Factors', 'Vibrio vulnificus', 'Water Microbiology'] | 15,008,814 | [['B01.050'], ['G16.500.275.157', 'N06.230.124'], ['B01.050.150.900.493.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.500.275.725.500'], ['G01.910.857'], ['B03.440.450.900.859.900', 'B03.660.250.830.830.900'], ['H01.158.273.540.274.777', 'N06.850.425.450']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A complex array of Hpr consensus DNA recognition sequences proximal to the enterotoxin gene in Clostridium perfringens type A. | Enterotoxin production in Clostridium perfringens is both strain dependent and sporulation associated. Underlying these phenotypic observations must lie a genetic and molecular explanation and the principal keys will be held within the DNA sequence both upstream and downstream of the structural gene cpe. In accordance ... | ['Base Sequence', 'Chromosome Mapping', 'Clostridium perfringens', 'Consensus Sequence', 'DNA Primers', 'DNA, Bacterial', 'Enterotoxins', 'Genes, Bacterial', 'Molecular Sequence Data', 'Open Reading Frames', 'Phenotype', 'Polymerase Chain Reaction', 'Promoter Regions, Genetic', 'Salmonella typhimurium', 'Sequence Homol... | 8,162,194 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['B03.300.390.400.200.575', 'B03.353.625.375.500.575', 'B03.510.415.400.200.575'], ['G02.111.570.580.175'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.212'], ['D23.946.330'], ['G05.360.340.024.340.364.249', 'G05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[A case of epidermoid cyst of the testis]. | The epidermoid cyst of the testis represents about 1% of all testicle tumours. The average age of presentation ranges from the second and the fourth decade of life. Its clinical features do not differ from those of a testis malignancy. Preliminary clinical and laboratory findings do not determine the diagnosis. The Aut... | ['Adolescent', 'Epidermal Cyst', 'Humans', 'Male', 'Testicular Diseases'] | 2,518,309 | [['M01.060.057'], ['C04.182.254'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.829', 'C19.391.829']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Root fracture detection: a comparison of direct digital radiography with conventional radiography. | OBJECTIVES: To compare the diagnostic potential of direct digital radiography with conventional film for detecting experimental root fractures.METHODS: Two hundred and one extracted single-rooted human teeth were endodontically instrumented and divided into two groups, a control group of 100 teeth and a fractured group... | ['Chi-Square Distribution', 'Humans', 'Incisor', 'Observer Variation', 'Radiography, Dental', 'Radiography, Dental, Digital', 'Tooth Fractures', 'Tooth Root'] | 11,313,731 | [['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E01.370.350.700.720', 'E06.342.764'], ['E01.370.350.600.350.700.690... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Recommendations of the Spanish Society of Otolaryngology and Head and Neck Surgery for performing tracheotomies in patients infected by the coronavirus, Covid-19. | The recent COVID-19 (coronavirus) pandemic is causing an increase in the number of patients who, due to their pulmonary ventilatory status, may require orotracheal intubation. COVID-19 infection has demonstrated a high rate of transmissibility, especially via the respiratory tract and by droplet spread. The Spanish Soc... | ['Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Emergencies', 'Humans', 'Intubation, Intratracheal', 'Otolaryngology', 'Pandemics', 'Pneumonia, Viral', 'SARS-CoV-2', 'Societies, Medical', 'Spain', 'Tracheotomy', 'Universal Precautions'] | 32,303,336 | [['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors. | An efficient synthesis of a library of 5-amino-thiazolo[4,5-d]pyrimidines is reported. Regioselective displacements of chlorines, as well as regioselective diazotation reactions are described, which allow the introduction of structural diversity on the scaffold by consecutive reactions. Screening of this focused librar... | ['Adenosine Triphosphatases', 'Bacterial Proteins', 'Escherichia coli', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Membrane Transport Proteins', 'Pyrimidines', 'SEC Translocation Channels', 'SecA Proteins', 'Staphylococcus aureus'] | 21,094,610 | [['D08.811.277.040.025'], ['D12.776.097'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.867.519'], ['E05.196.566'], ['D12.776.157.530', 'D12.776.543.585'], ['D03.383.742'], ['D05.500.890.625', 'D12.776.157.530.875', 'D12.776.543.585.875'], ['D08.811.277.040.025.494'], ['B03.300.390.400.800.750.100'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A facility-wide approach to recreation programming for adults who are severely and profoundly retarded. | A facility-wide recreation program was designed and implemented in order to increase staff and client participation in daily leisure activities at an intermediate care facility for severely and profoundly mentally retarded adults. The baseline phase of the study consisted of having recreational materials available duri... | ['Adult', 'Humans', 'Intellectual Disability', 'Intermediate Care Facilities', 'Nursing Homes', 'Recreation', 'Therapeutics'] | 10,273,994 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['N02.278.825.610.480'], ['N02.278.825.610'], ['I03.450.642'], ['E02']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Developmental changes in brain metabolism in sedated rhesus macaques and vervet monkeys revealed by positron emission tomography. | The present positron emission tomography study used 2-deoxy-2[18F]fluoro-D-glucose to examine age-related changes in local cerebral metabolic rates for glucose (LCMRglc) in sedated rhesus macaques and vervet monkeys. Nineteen vervet monkeys were scanned in a cross-sectional design, which consisted of three age groups (... | ['Age Distribution', 'Age Factors', 'Animals', 'Brain', 'Brain Mapping', 'Cerebral Cortex', 'Chlorocebus aethiops', 'Deoxyglucose', 'Fluorodeoxyglucose F18', 'Glucose', 'Macaca mulatta', 'Male', 'Thalamus', 'Tomography, Emission-Computed'] | 7,613,078 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D09.254.229'], ['D09.254.22... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Relationship between olfactory function and social cognition in euthymic bipolar patients. | OBJECTIVE/INTRODUCTION: There is a close functional and neuroanatomical relationship between olfactory ability and emotional processing. The present study seeks to explore the association between olfactory ability and social cognition, especially facial emotion perception, in euthymic bipolar patients.METHODS: Thirty-n... | ['Adult', 'Bipolar Disorder', 'Case-Control Studies', 'Facial Recognition', 'Female', 'Humans', 'Male', 'Middle Aged', 'Olfactory Perception', 'Social Perception', 'Theory of Mind', 'Young Adult'] | 23,759,120 | [['M01.060.116'], ['F03.084.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593.485'], ['F02.463.593.752'], ['F02.463.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Household health care-seeking costs: experiences from a randomized, controlled trial of community-based malaria and pneumonia treatment among under-fives in eastern Uganda. | BACKGROUND: Home and community-based combined treatment of malaria and pneumonia has been promoted in Uganda since mid 2011. The combined treatment is justified given the considerable overlap between the symptoms of malaria and pneumonia among infants. There is limited evidence about the extent to which community-based... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Family Characteristics', 'Female', 'Health Expenditures', 'Humans', 'Infant', 'Malaria', 'Middle Aged', 'Patient Acceptance of Health Care', 'Pneumonia', 'Randomized Controlled Trials as Topic', 'Rural Population', 'Uganda', 'Urban Popul... | 24,902,959 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life. | OBJECTIVES: This is to identify factors affecting the prevalence of Lactobacillus reuteri in maternal faeces and breast milk and infant faeces after oral supplementation with L reuteri and to assess the influence on microbial ecology, particularly Clostridium difficile and Bifidobacterium colonization.MATERIALS AND MET... | ['Adult', 'Bifidobacterium', 'Clostridioides difficile', 'Colony Count, Microbial', 'Colostrum', 'Dietary Supplements', 'Double-Blind Method', 'Feces', 'Female', 'Humans', 'Hypersensitivity', 'Infant', 'Lactobacillus reuteri', 'Milk, Human', 'Pregnancy', 'Probiotics'] | 19,525,871 | [['M01.060.116'], ['B03.510.024.100', 'B03.510.460.400.400.049.100'], ['B03.353.625.657.500'], ['E01.370.225.875.220', 'E05.200.875.220'], ['A12.200.194'], ['G07.203.300.456', 'J02.500.456'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['A12.459'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Combined Fourier amplitude and phase imaging in patients with coronary artery disease. | Fourier amplitude and phase image analysis were evaluated in 66 patients. Thirty patients served as a control group and 36 had coronary artery disease (CAD). Each patient in our control group had a rest and exercise radionuclide cineangiogram (RNCA) study (60 total). The amplitude and phase images for controls were uni... | ['Adult', 'Aged', 'Cardiac Catheterization', 'Coronary Disease', 'Exercise Test', 'Female', 'Fourier Analysis', 'Humans', 'Male', 'Middle Aged', 'Myocardial Contraction', 'Myocardial Infarction', 'Radionuclide Imaging', 'Rest', 'Sodium Pertechnetate Tc 99m', 'Stroke Volume'] | 6,096,069 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['C14.280.647.250', 'C14.907.585.250'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G09.330.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Trees of trees: an approach to comparing multiple alternative phylogenies. | Phylogenetic analysis very commonly produces several alternative trees for a given fixed set of taxa. For example, different sets of orthologous genes may be analyzed, or the analysis may sample from a distribution of probable trees. This article describes an approach to comparing and visualizing multiple alternative p... | ['Animals', 'Classification', 'DNA', 'Evolution, Molecular', 'Fishes', 'Genetic Variation', 'Phylogeny', 'Plants'] | 18,853,364 | [['B01.050'], ['L01.100', 'L01.453.245.275'], ['D13.444.308'], ['G05.045.250', 'G16.075.250'], ['B01.050.150.900.493'], ['G05.365'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.650']] | ['Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lack of dose-response with Pancrease MT for the treatment of exocrine pancreatic insufficiency in adults. | BACKGROUND: Choosing the optimum pancreatic enzyme replacement therapy for patients with exocrine insufficiency remains a problem. An enteric coated enzyme microsphere pancreatic enzyme preparation (Pancrease) has been marketed with several levels of lipase activity, implying that there is a dose-response relationship ... | ['Adult', 'Celiac Disease', 'Cross-Over Studies', 'Dose-Response Relationship, Drug', 'Exocrine Pancreatic Insufficiency', 'Feces', 'Gastrointestinal Agents', 'Humans', 'Lipase', 'Middle Aged', 'Pancreatin', 'Single-Blind Method'] | 9,354,210 | [['M01.060.116'], ['C06.405.469.637.250', 'C18.452.603.250'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.690.773.875', 'G07.690.936.500'], ['C06.689.276'], ['A12.459'], ['D27.505.954.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.352.100.400'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of elongation factor 2 with ribosomes during growth of a murine ascitic tumor. | The amount of elongation factor 2 (EF-2) associated with different ribosomal fractions (mono- and polyribosomes) isolated from a methylcholanthrene-induced sarcoma is estimated during tumor growth (exponential and plateau phase of growth). Direct EF-2 quantification is obtained by a modification of the method of the di... | ['Animals', 'Cell Division', 'Cell Fractionation', 'Male', 'Mice', 'Mice, Inbred C3H', 'Neoplasm Transplantation', 'Peptide Elongation Factor 2', 'Peptide Elongation Factors', 'Ribosomes', 'Sarcoma, Experimental'] | 6,850,553 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.242.251'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.388', 'B01.050.150.900.649.313.992.635.505.500.400.388'], ['E05.624'], ['D08.811.277.040.330.300.100.102', 'D12.776.157.325.150.102', 'D12.776.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effective atomic number of some sugars and amino acids for scattering of (241)Am and (137)Cs gamma rays at low momentum transfer. | In this paper, we report the effective atomic number of some H, C, N and O based sugars and amino acids. These have been determined by using a handy expression which is based on the theoretical angle integrated small angle (coherent+incoherent) scattering cross sections of seven elements of Z?13 in four angular ranges ... | ['Algorithms', 'Americium', 'Amino Acids', 'Carbohydrates', 'Cesium', 'Computer Simulation', 'Gamma Rays', 'Linear Energy Transfer', 'Models, Chemical', 'Protons', 'Radiation Dosage', 'Scattering, Radiation'] | 26,073,268 | [['G17.035', 'L01.224.050'], ['D01.268.271.100.050', 'D01.268.556.037', 'D01.496.749.305.100.050', 'D01.552.020.086', 'D01.552.544.037'], ['D12.125'], ['D09'], ['D01.268.549.125', 'D01.268.556.165', 'D01.552.528.160', 'D01.552.544.165'], ['L01.224.160'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Free radicals and scavenging enzymes in chronic tonsillitis. | OBJECTIVE: This study aimed to define the relationship between chronic tonsillitis and levels of malondialdehyde and superoxide dismutase in free radical and antioxidant forms. It is suggested that free oxygen radicals may play a role in chronic tonsillitis. Materials and methods One hundred twenty-four patients were e... | ['Adolescent', 'Child', 'Child, Preschool', 'Chronic Disease', 'Female', 'Free Radical Scavengers', 'Free Radicals', 'Humans', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Postoperative Care', 'Preoperative Care', 'Superoxide Dismutase', 'Tonsillectomy', 'Tonsillitis'] | 12,958,578 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['D27.505.519.217.500'], ['D01.339', 'D02.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['D02.047.700'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['E02.760.795', 'E04.604.750', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determination of lipophilic marine toxins in fresh and processed shellfish using modified QuEChERS and ultra-high-performance liquid chromatography-tandem mass spectrometry. | A simple QuEChERS method coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed to improve the extraction efficiency of lipophilic marine toxins (yessotoxins, dinophysistoxins, okadaic acid, azazspiracids, and spirolides) in fresh and processed shellfish products. ... | ['Animals', 'Chromatography, High Pressure Liquid', 'Freezing', 'Graphite', 'Limit of Detection', 'Marine Toxins', 'Okadaic Acid', 'Oxocins', 'Seafood', 'Shellfish', 'Solid Phase Extraction', 'Tandem Mass Spectrometry'] | 30,309,565 | [['B01.050'], ['E05.196.181.400.300'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['D01.268.150.300', 'D01.578.300'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D23.946.580'], ['D02.355.291.705', 'D23.946.580.710'], ['D02.355.291.866', 'D03.383.585'], ['G07.203.300.600.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants. | Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is the name given to a family of parasite proteins that are inserted into the infected erythrocyte surface. Studies using agglutination assays have shown previously that PfEMP1 epitopes are extremely diverse. In a study in Kenya, 21 parasite isolates, includ... | ['Agglutination Tests', 'Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Antigens, Surface', 'Blood Transfusion', 'Child', 'Erythrocytes', 'Genetic Variation', 'Humans', 'Infant', 'Kenya', 'Malaria, Falciparum', 'Plasmodium falciparum', 'Protozoan Proteins', 'Reproducibility of Results'] | 9,916,084 | [['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['D23.050.301'], ['E02.095.135'], ['M01.060.406'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G05.365'], ['B0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. | The principal function of bacterial AB5 toxin B subunits is to interact with glycan receptors on the surfaces of target cells and mediate the internalization of holotoxin. However, B subunit-receptor interactions also have the potential to impact cell signaling pathways and, in so doing, contribute to pathogenesis inde... | ['Bacterial Toxins', 'Brain', 'Cell Adhesion', 'Cell Line', 'Cytokines', 'Dose-Response Relationship, Drug', 'Endothelial Cells', 'Epithelial Cells', 'Gene Expression Regulation', 'Humans', 'Intestinal Mucosa', 'Macrophages', 'Protein Subunits', 'Salmonella typhi'] | 23,250,951 | [['D23.946.123'], ['A08.186.211'], ['G04.022'], ['A11.251.210'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.436.275'], ['A11.436'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.369', 'A10.615.550.444'], ['A11.329.372', 'A11.627.482... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Genetic susceptibility to cancer]. | Hereditary predisposition is a common trait of many cancers. 15 to 20 percent of all cancers occur in individuals who have inherited a single gene alteration being members of families where multiple persons carry a high risk of developing cancer. Other than these so-called high penetrance genes which confer elevated ri... | ['Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor', 'Genetic Predisposition to Disease', 'Humans', 'Mutation', 'Neoplasms'] | 12,089,987 | [['G05.308.370'], ['G05.360.340.024.340.375.249', 'G05.360.340.024.340.415.400'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['C04']] | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Features of Urine Biomineralization in Long-Livers]. | BACKGROUND: The increasing number of long-livers in the developed countries indicates the demand for clarification of the body vital systems' functioningfeatures which allow the long-livers to prolong their active involvement in social life.OBJECTIVE: Aim of our study/research was to define a functional condition of ur... | ['Aged, 80 and over', 'Aging', 'Atherosclerosis', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Minerals', 'Retrospective Studies', 'Time Factors', 'Urinalysis', 'Urine'] | 26,710,521 | [['M01.060.116.100.080'], ['G07.345.124'], ['C14.907.137.126.307'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.578'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The preference for one limb in rats--the result of learning in an experiment or an individual characteristic?]. | The problem was studied whether an initial preference of one limb exists in rats connected with interhemispheric asymmetry or it appears during the procedure of testing (the first successful movement of one limb becomes consolidated). The work consisted in obtaining experimental retrograde amnesia after preliminary det... | ['Amnesia, Retrograde', 'Animals', 'Dominance, Cerebral', 'Electroshock', 'Extremities', 'Feeding Behavior', 'Individuality', 'Learning', 'Male', 'Rats', 'Time Factors'] | 3,223,071 | [['C10.597.606.525.100.150', 'C23.888.592.604.529.100.150', 'F01.700.625.100.150', 'F03.615.200.150'], ['B01.050'], ['F02.830.297', 'G11.561.225'], ['E05.723.402.403', 'F04.669.224'], ['A01.378'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F01.752.488'], ['F02.463.425', 'F02.784.629.529'], ['B01.050.150.9... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals. | Zomepirac sodium inhibited the reflex hypertension caused by an injection of bradykinin into the splenic artery of anaesthetized dogs, but not that by injection of bradykinin plus PGE1. In the rat acetic acid writhing test, the potency ratio of intraperitoneal (ED50 = 0.41 microgram/kg) to intravenous (ED50 = 33.5 micr... | ['Alprostadil', 'Analgesics', 'Animals', 'Ascitic Fluid', 'Bradykinin', 'Dogs', 'Hypertension', 'Injections, Intraventricular', 'Male', 'Naloxone', 'Pain', 'Prostaglandins E', 'Pyrroles', 'Rats', 'Rats, Inbred Strains', 'Tolmetin'] | 6,685,202 | [['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['A12.207.119'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. | As part of the nutrition-countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model, we aimed to examine the recovery of the lumbar intervertebral discs a... | ['Adult', 'Bed Rest', 'Bicarbonates', 'Bone Resorption', 'Cross-Sectional Studies', 'Germany', 'Head-Down Tilt', 'Humans', 'Intervertebral Disc', 'Low Back Pain', 'Lumbar Vertebrae', 'Lumbosacral Region', 'Magnetic Resonance Imaging', 'Male', 'Motor Activity', 'Muscle, Skeletal', 'Pilot Projects', 'Potassium Compounds'... | 21,799,122 | [['M01.060.116'], ['E02.075'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['C05.116.264', 'G11.427.213.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.542.315'], ['G11.427.695.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.165.308.410', 'A02.835.232.83... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity. | A series of 8-substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones (2), structurally related to the imidazoacridinones (1), was synthesized and tested for cytotoxic and antineoplastic activity. Preliminary biological results indicated that the 8-OH derivatives possess the highest antitumor activity. ... | ['Acridines', 'Animals', 'Antineoplastic Agents', 'Cell Survival', 'Chemical Phenomena', 'Chemistry, Physical', 'Dose-Response Relationship, Drug', 'Humans', 'Rats', 'Triazoles', 'Tumor Cells, Cultured'] | 2,213,837 | [['D03.633.300.046'], ['B01.050'], ['D27.505.954.248'], ['G04.346'], ['G02'], ['H01.181.529'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.700'], ['D03.383.129.799'], ['A11.251.860']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein crystallisation on chemically modified mica surfaces. | Chemically modified mica sheets have been tested as heterogeneous nucleant surfaces for lysozyme, concanavalin A and thaumatin. Smooth mica surfaces with reduced hydrophilic properties and different density of ionisable groups have been prepared by a silanisation reaction using mixtures of n-propyltriethoxysilane and 3... | ['Aluminum Silicates', 'Animals', 'Concanavalin A', 'Crystallization', 'Muramidase', 'Particle Size', 'Plant Proteins', 'Propylamines', 'Proteins', 'Silanes', 'Surface Properties', 'Sweetening Agents'] | 12,351,879 | [['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['B01.050'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['E05.196.300', 'G02.171'], ['D08.811.277.450.642'], ['G02.712'], ['D12.776.765'], ['D02.092.831'], ['D12.776'], ['D01.837.700'], ['G02.860'], ['D27.720.372.300.353.609... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Topography of Vertebral Artery Origin Plaques: Characteristics and Determinants. | BACKGROUND: Atherosclerotic plaques located at the vertebral artery ostium (VAo) are a mechanism for posterior circulation stroke, but little is known about VAo plaque topography and formation. In this study, we describe the topography of atherosclerotic plaques involving the origin of the vertebral artery (VA).METHODS... | ['Aged', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Plaque, Atherosclerotic', 'Retrospective Studies', 'Risk Factors', 'Subclavian Artery', 'Ultrasonography, Doppler, Duplex', 'Vertebral Artery'] | 30,027,627 | [['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.823'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Recycling of cooking oil fume condensate for the production of rhamnolipids by Pseudomonas aeruginosa WB505. | Rhamnolipids (RLs) are anionic biosurfactants with great application potential. This study explored the possibility of producing RLs from cooking oil fume condensates (COFCs) collected from range hoods. A mutant of Pseudomonas aeruginosa AB93066 was obtained and used to produce RLs from COFCs as a substrate. RL yields ... | ['Cooking', 'Glycolipids', 'Plant Oils', 'Pseudomonas aeruginosa', 'Recycling'] | 30,741,355 | [['J01.576.423.200.200'], ['D09.400.410', 'D10.390'], ['D10.627.700', 'D20.215.784.750'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['N06.850.780.200.800.800.525', 'N06.850.860.510.244']] | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Testosterone-secreting virilizing adrenal adenoma with human chorionic gonadotrophin receptors and 21-hydroxylase deficiency. | A 60-year-old woman was evaluated for persistently elevated serum testosterone concentrations after bilateral ovariectomy. Her serum cortisol, androstenedione, dehydroepiandrosterone sulphate and 17-hydroxyprogesterone levels were normal, and decreased after dexamethasone administration. Those of testosterone (17.8-18.... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Adrenal Hyperplasia, Congenital', 'Female', 'Humans', 'Middle Aged', 'Receptors, LH', 'Testosterone', 'Tumor Cells, Cultured'] | 1,848,485 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['C12.706.316.090.500', 'C13.351.875.253.090.500', 'C16.131.939.316.129.500', 'C16.320.033', 'C16.320.565.925.249', 'C18.452.648.925.249', 'C19.053.440', 'C19.391.119.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'],... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Defective interfering particles of parvovirus H-1. | Defective interfering particles of the parvovirus H-1 were produced by serial propagation at high multiplicities of infection. Such particles interfere with the synthesis of capsid proteins and infectious virus of standard H-1. The interference is sensitive to UV irradiation, dependent on the multiplicity of the challe... | ['Capsid', 'Cell Line', 'DNA Replication', 'DNA, Viral', 'Defective Viruses', 'Genes, Viral', 'Parvoviridae', 'Ultraviolet Rays', 'Viral Interference', 'Virus Replication'] | 691,114 | [['A21.249.500.250'], ['A11.251.210'], ['G02.111.225', 'G05.226'], ['D13.444.308.568'], ['B04.265'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B04.280.580'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G1... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Automated protein analysis by online detection of laser-induced fluorescence in slab gels and 3-D geometry gels. | Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) still remains the most reliable and comprehensive analytical method for the evaluation of protein extracts. However, conventional SDS-PAGE is time-consuming and, thus, unpractical if several tens or hundreds of samples must be examined. We show that S... | ['Automation', 'Carbocyanines', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli Proteins', 'Fluorescent Dyes', 'Online Systems', 'Proteins', 'Sensitivity and Specificity'] | 16,850,506 | [['J01.897.104'], ['D02.455.326.397.300'], ['E05.196.401.402', 'E05.301.300.319'], ['D12.776.097.275'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['L01.313.500.750.300.742'], ['D12.776'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.85... | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Using HIV Surveillance Data to Link People to HIV Medical Care, 5 US States, 2012-2015. | INTRODUCTION: From 2012 through 2015, the Centers for Disease Control and Prevention (CDC) provided funding to 5 health departments for demonstration projects using HIV surveillance data to link people with newly diagnosed HIV to care. We assessed how well these health departments established linkage to care, how the d... | ['Adult', 'Centers for Disease Control and Prevention, U.S.', 'Financing, Government', 'HIV Infections', 'Health Services Accessibility', 'Humans', 'Mass Screening', 'Public Health', 'United States'] | 29,750,891 | [['M01.060.116'], ['I01.409.418.750.600.650.200', 'N03.540.348.500.500.600.650.225'], ['N03.219.521.346'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Development and application of a "real time" lead-in-air analyzer in controlling lead exposure at a primary lead smelter. | To assist in locating and quantifying fugitive emissions in a primary lead smelter, a "real time" lead-in-air analyzer has been developed. Dust is collected on paper tape filters and the lead analysed by X-ray fluorescence. The unit has been used successfully to assist in the implementation of an engineering control mo... | ['Air Pollutants, Occupational', 'Lead', 'Occupational Medicine'] | 3,799,479 | [['D27.888.284.101.268'], ['D01.268.556.435', 'D01.552.544.435'], ['H02.403.720.750.510']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[The role of lactate acidosis and enzyme hyperactivity in evaluating hypoxic organ disorders in patients following cardiopulmonary by?ass]. | One hundred and fifty patients after cardiopulmonary bypass surgery have been examined. It has been shown that overall enzyme activity should be taken into consideration when determining the genesis of postoperative hyperenzymemia and diagnosing the topical (organic) damage. High lactate level (6-8 mmol/l) reflects pro... | ['Acidosis, Lactic', 'Adolescent', 'Adult', 'Aprotinin', 'Cardiopulmonary Bypass', 'Child', 'Humans', 'Hypoxia', 'Middle Aged', 'Postoperative Complications'] | 1,384,400 | [['C18.452.076.176.180'], ['M01.060.057'], ['M01.060.116'], ['D12.776.083'], ['E04.292.413'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['M01.060.116.630'], ['C23.550.767']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Candidal infections in neonates of very low birth weight. | Candida infections represent a serious cause of morbidity and mortality in sick low birth weight infants cared for in the neonatal intensive care unit. Often, the infection goes undiagnosed, or the candidal isolate is regarded as a contaminant. There is also fear of potential toxicity from treatment. We have reported a... | ['Candida albicans', 'Candidiasis', 'Female', 'Humans', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature, Diseases'] | 2,643,169 | [['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C01.150.703.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520.460'], ['M01.060.703.520'], ['C16.614.521']] | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Male nursing students' perception of dignity in neonatal intensive care units. | INTRODUCTION: Maintaining dignity is one of the most important human rights. However, maintaining and promoting the dignity of nursing students as an important caregiver group has scarcely been considered. Dignity can be viewed as an abstract concept particularly in relation to the perspective of male nursing student p... | ['Adult', 'Attitude of Health Personnel', 'Focus Groups', 'Humans', 'Intensive Care Units, Neonatal', 'Interviews as Topic', 'Iran', 'Male', 'Nurses, Male', 'Perception', 'Personhood', 'Qualitative Research', 'Students, Nursing'] | 31,177,916 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493.390.380'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['Z01.252.245.500.350'], ['M01.390.660'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Humanities [K]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway. | BACKGROUND: We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in advanced cancers based on its promising safety and antitumor efficacy in several preclinical models.M... | ['Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Drug Screening Assays, Antitumor', 'Fibroblasts', 'Forkhead Box Protein O3', 'Forkhead Transcription Factors', 'Genes, Reporter', 'Heterocyclic Compounds, 4 or More Rings', 'Humans', 'Imidazoles', 'Luciferases', 'Mutagens', 'Promoter Regions, Genetic', 'Pyridi... | 25,927,855 | [['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['A11.329.228'], ['D12.776.260.950.249.125', 'D12.776.930.977.249.125'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['G05.360.340.024.340.435'], ['D03.633... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Direct Tracking of Particles and Quantification of Margination in Blood Flow. | Margination refers to the migration of particles toward blood vessel walls during blood flow. Understanding the mechanisms that lead to margination will aid in tailoring the attributes of drug-carrying particles for effective drug delivery. Most previous studies evaluated the margination propensity of these particles v... | ['Animals', 'Blood', 'Cattle', 'Fluorescent Dyes', 'Hemorheology', 'Lab-On-A-Chip Devices', 'Microfluidics', 'Models, Biological', 'Particle Size', 'Water'] | 27,705,771 | [['B01.050'], ['A12.207.152', 'A15.145'], ['B01.050.150.900.649.313.500.380.271'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E05.830.250', 'G09.188.370', 'G09.330.380.630'], ['E07.305.343.500'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['E05.599.395'], ['G02.712'], ['D01.045.250.875', 'D01.248... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Circulating antim?llerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term. | OBJECTIVE: To investigate plasma antim?llerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term.DESIGN: Case-control study.SETTING: University-affiliated hospital.PATIENT(S): A total of 74 pregnant women at term: 25 women... | ['Adult', 'Androstenedione', 'Anti-Mullerian Hormone', 'Biomarkers', 'Case-Control Studies', 'Estradiol', 'Female', 'Gonadal Steroid Hormones', 'Humans', 'Polycystic Ovary Syndrome', 'Pregnancy', 'Sex Factors', 'Term Birth', 'Testosterone'] | 30,630,591 | [['M01.060.116'], ['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['D06.472.334.984.500', 'D09.400.430.625', 'D12.776.395.089'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D04.210.500.365.415.248', 'D06.472.334.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Social public health requirements--motives for collective and individual action?]. | The knowledge and the abilities acquired as well as the experience of individuals in the field of hygiene alone are not sufficient for consequent action in accordance with the demands of hygiene. Individual possibilities for human behaviour can only be realized under certain social conditions. Concrete elements of soci... | ['Germany, East', 'Humans', 'Public Health', 'Social Conditions', 'Socialism'] | 2,728,554 | [['Z01.586.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['I01.880.853.450', 'N01.824.827'], ['I01.696.798']] | ['Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Lipocortin I (annexin I) is preferentially localized on the plasma membrane in keratinocytes of psoriatic lesional epidermis as shown by immunofluorescence microscopy. | Lipocortin I (LPC-I, also called annexin I) is a 35-kD protein that binds phospholipids and actin in a Ca(++)-dependent manner. It is also a major substrate for EGF receptor/kinase and protein kinase C, and a putative inhibitor of phospholipase A2, which produces chemical mediators to cause inflammation. Psoriasis (PS)... | ['Annexins', 'Calcium-Binding Proteins', 'Fluorescent Antibody Technique', 'Humans', 'Immunoblotting', 'Keratinocytes', 'Microscopy, Fluorescence', 'Psoriasis'] | 1,836,217 | [['D12.776.157.125.050'], ['D12.776.157.125'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['A11.409.500', 'A11.436.397'], ['E01.370.350.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peptide mimicrying between SARS coronavirus spike protein and human proteins reacts with SARS patient serum. | Molecular mimicry, defined as similar structures shared by molecules from dissimilar genes or proteins, is a general strategy used by pathogens to infect host cells. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The spike (S) protein of SAR... | ['Binding Sites', 'Blood Proteins', 'Humans', 'Membrane Glycoproteins', 'Molecular Mimicry', 'Protein Binding', 'Sequence Homology, Amino Acid', 'Severe Acute Respiratory Syndrome', 'Spike Glycoprotein, Coronavirus', 'Viral Envelope Proteins'] | 18,320,019 | [['G02.111.570.120'], ['D12.776.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['G02.111.560', 'G05.545', 'G16.012.750.500'], ['G02.111.679', 'G03.808'], ['G02.111.810.200', 'G05.810.200'], ['C01.748.730', 'C01.925.782.600.550.200.750', 'C08.730.730'], ['D12.776.543.512.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cystic angiomatosis of bone with hematologic involvement. Report of a case]. | A case of cystic angiomatosis of bone without visceral involvement is presented. Lesions were noted in: skull, ribs, pelvis, long bones and phalanges. Besides clinical and radiological findings, the case, associates pancytopenia and coagulation disorders. The possibility of a bone marrow failure due to invasion of marr... | ['Angiomatosis', 'Blood Coagulation Disorders', 'Bone Neoplasms', 'Child, Preschool', 'Humans', 'Male', 'Pancytopenia', 'Radiography'] | 3,178,064 | [['C14.907.077'], ['C15.378.100'], ['C04.588.149', 'C05.116.231'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.700'], ['E01.370.350.700']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of bone marrow mesenchymal stem cells on T-cell subgroups]. | The aim of this study was to investigate the effect of human bone marrow mesenchymal stem cells on human T-cell proliferation resulted from stimulation with PHA and possible immunomodulating mechanism. T cells were positively selected by CD3(+) magnetic beads, and were then co-cultured with irradiated MSCs overnight be... | ['Bone Marrow Cells', 'CD4-CD8 Ratio', 'Cell Proliferation', 'Cells, Cultured', 'Coculture Techniques', 'Humans', 'Mesenchymal Stem Cells', 'T-Lymphocyte Subsets'] | 18,718,078 | [['A11.148', 'A15.378.316'], ['E01.370.225.500.195.107.595.500.150.160', 'E01.370.225.625.107.595.500.150.160', 'E05.200.500.195.107.595.500.150.160', 'E05.200.625.107.595.500.150.160', 'E05.242.195.107.595.500.150.160', 'G04.140.107.595.500.150.160', 'G09.188.105.595.500.150.160', 'G12.248'], ['G04.161.750', 'G07.345.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer. | BACKGROUND: Infertility is a known side-effect of oncotherapy in cancer survivors, and often compromises the quality of life. The present study was undertaken to detect very small embryonic-like stem cells (VSELs) in testicular biopsies from young adult survivors of childhood cancer who had azoospermia. VSELs have been... | ['Adult', 'Azoospermia', 'Biopsy', 'Cell Differentiation', 'Embryonic Stem Cells', 'Humans', 'Male', 'Neoplasms', 'Quality of Life', 'Spermatogenesis', 'Survivors', 'Testis', 'Young Adult'] | 26,553,338 | [['M01.060.116'], ['C12.294.365.700.380'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G04.152'], ['A11.872.700.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['I01.800', 'K01.752.400.750', 'N06.850.50... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Cell culture plastics with immobilized interleukin-4 for monocyte differentiation. | Standard cell culture plastic was surface modified by passive adsorption or covalent attachment of interleukin (IL)-4 and investigated for its ability to induce differentiation of human monocytes into mature dendritic cells, a process dose-dependently regulated by IL-4. Covalent attachment of IL-4 proceeded via anthraq... | ['Adsorption', 'Anthraquinones', 'Cell Culture Techniques', 'Cell Differentiation', 'Dendritic Cells', 'Down-Regulation', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Immobilized Proteins', 'Interleukin-4', 'Monocytes', 'Plastics', 'Solutions', 'Surface Properties', 'Triazines', 'Up-Regulation'] | 21,171,157 | [['G01.030', 'G02.020'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.478.566.35... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Acute Fulminant Uremic Neuropathy Following Coronary Angiography Mimicking Guillain Barre Syndrome. | A 55 yr old diabetic lady suffered a posterior wall STEMI. She developed Contrast induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan Barre Syndrome, hence reported. | ['Coronary Angiography', 'Diabetic Neuropathies', 'Female', 'Guillain-Barre Syndrome', 'Humans', 'Renal Insufficiency'] | 31,562,732 | [['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C10.668.829.300', 'C19.246.099.937'], ['C10.114.750.100', 'C10.314.750.450', 'C10.668.829.350', 'C10.668.829.800.750.300', 'C20.111.258.750.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780', 'C1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ransacking the curve of cardiac isovolumic pressure decay by logistic-and-oscillation regression. | The decelerative part of the left ventricular isovolumic pressure decay is an important phase to make the heart ready for diastolic refill (lusitropy). Its widely used characterization by an exponential regression with zero pressure asymptote or coestimated asymptote provides empirically biased time constant estimates ... | ['Animals', 'Cardiac Volume', 'Ferrets', 'Guinea Pigs', 'Logistic Models', 'Models, Theoretical', 'Pressure', 'Rats', 'Regression Analysis', 'Ventricular Function'] | 15,631,690 | [['B01.050'], ['G09.330.380.249'], ['B01.050.150.900.649.313.750.250.575.350'], ['B01.050.150.900.649.313.992.550'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cortical thickness and VBM-DARTEL in late-life depression. | BACKGROUND: Numerous studies have revealed structural brain changes in late life depression, mainly in white matter or whole lobes with few focussing just on grey matter (GM). The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness... | ['Adult', 'Age of Onset', 'Aged', 'Aging', 'Algorithms', 'Brain', 'Case-Control Studies', 'Cerebral Cortex', 'Depression', 'Depressive Disorder', 'Female', 'Frontal Lobe', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged'] | 21,550,668 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['G07.345.124'], ['G17.035', 'L01.224.050'], ['A08.186.211'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.200.885.287.500'], ['F01.145.126.350'], ['F03.600.300'], ['A08.186.211.200.885... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Identification and characterization of mitochondrial Mia40 as an iron-sulfur protein. | Mia40 is a highly conserved mitochondrial protein that plays an essential role in the import and oxidative folding of many proteins of the mitochondrial intermembrane space. Mia40 uses its redox active CPC motif to shuttle disulfides between its client proteins (newly imported proteins) and the thiol oxidase Erv1. As a... | ['Binding Sites', 'Escherichia coli', 'Iron', 'Iron-Sulfur Proteins', 'Mitochondria', 'Mitochondrial Membrane Transport Proteins', 'Oxidation-Reduction', 'Protein Binding', 'Protein Multimerization', 'Protein Stability', 'Protein Structure, Tertiary', 'Recombinant Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces c... | 23,834,247 | [['G02.111.570.120'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D12.776.157.427.374.375', 'D12.776.556.579.374.375'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D12.776.543.585.475', 'D12.776.575.750'], ['G02.700', 'G03.295.531'], ['G... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Procyanidins from the herb of Hypericum perforatum. | From the aqueous acetone extract of the herb of Hypericum perforatum the flavanols catechin (1) and epicatechin (2), and the procyanidins A2 (9), B1 (3), B2 (4), B3 (5), B5 (6), B7 (7) and C1 (8) were isolated. Their structures were established as their peracetate derivatives, on the basis of chemical and spectral evid... | ['Antioxidants', 'Biflavonoids', 'Catechin', 'Hypericum', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Molecular Weight', 'Oxidation-Reduction', 'Plant Extracts', 'Plants, Medicinal', 'Proanthocyanidins', 'Rosales'] | 11,446,175 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D03.383.663.283.266.450.190', 'D03.633.100.150.266.450.190'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['B01.650.940.800.575.912.250.859.625.500'], ['E05.196.867.519'], ['G02.11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diagnostic relevance of fine needle aspiration cytology in nodular thyroid lesions]. | BACKGROUND/AIM: Fine needle aspiration cytology (FNAC) of the thyroid gland has been used as an initial investigative procedure of thyroid nodule(s) in the Department of Pathology at the Institute of Oncology of Vojvodina for more than 20 years. This procedure is rapid, inexpensive and technologically simple, yet it ha... | ['Biopsy, Fine-Needle', 'Female', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Sensitivity and Specificity', 'Thyroid Gland', 'Thyroid Neoplasms', 'Thyroid Nodule'] | 22,838,165 | [['E01.370.225.500.384.100.119.500', 'E01.370.225.998.054.119.500', 'E01.370.388.100.100.500', 'E04.074.119.500', 'E04.665.100.500', 'E05.200.500.384.100.119.500', 'E05.200.998.054.119.500', 'E05.242.384.100.119.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.71... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multimodal Drug Therapy and Physical Rehabilitation in the Successful Treatment of Capture Myopathy in a Lesser Flamingo (Phoeniconaias minor). | A wild-caught lesser flamingo (Phoeniconaias minor) from the Fort Worth Zoo (Fort Worth, TX, USA) presented with moderate lameness that progressed to the inability to stand 2 days after restraint and handling. Results of blood tests showed severely elevated creatine phosphokinase (CPK) and aspartate aminotransferase (A... | ['Animals', 'Animals, Zoo', 'Anti-Dyskinesia Agents', 'Anti-Infective Agents', 'Anti-Inflammatory Agents, Non-Steroidal', 'Bird Diseases', 'Birds', 'Fluid Therapy', 'Haloperidol', 'Male', 'Meloxicam', 'Methocarbamol', 'Muscle Relaxants, Central', 'Muscular Diseases', 'Physical Conditioning, Animal', 'Rehabilitation'] | 28,891,689 | [['B01.050'], ['B01.050.050.448'], ['D27.505.954.427.090'], ['D27.505.954.122'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C22.131'], ['B01.050.150.900.248'], ['E02.319.360'], ['D02.522.352.506'], ['D02.886.665.275', 'D02.886.675.448', 'D03.383.129.708.448', 'D03.383.855.275']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Characteristics of DEAE-dextran-MMA graft copolymer as a nonviral gene carrier. | A stable and soapless latex of diethylaminoethyl-dextran-methyl methacrylate (DEAE-dextran-MMA) graft copolymer (DDMC) has been developed for nonviral gene delivery vectors that are possible to autoclave. DDMC relatively easily formed a polyion complex between DNA and DDMC by the hydrophobic force of graft poly(MMA) de... | ['Animals', 'Cell Line', 'DEAE-Dextran', 'DNA', 'Diffusion', 'Drug Carriers', 'Drug Compounding', 'Humans', 'Kidney', 'Materials Testing', 'Methylmethacrylate', 'Nanostructures', 'Particle Size', 'Polymers', 'Salmon', 'Transfection', 'Viruses'] | 17,765,639 | [['B01.050'], ['A11.251.210'], ['D09.698.365.272.250'], ['D13.444.308'], ['G01.202', 'G02.196'], ['D26.255.260', 'E02.319.300.380'], ['E05.916.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['E05.570'], ['D02.241.081.069.800.550.450', 'D05.750.716.822.111.650.605.450', 'D25.720.716.822.111.650... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Management of urinary calculi during pregnancy. | Renal calculous disease is an infrequent but not insignificant occurrence during pregnancy. In 50 to 80% of the cases conservative management is appropriate and the stone will pass spontaneously. Should intervention be required, recent advances in stone management and techniques for urinary tract drainage may be succes... | ['Adolescent', 'Adult', 'Algorithms', 'Female', 'Humans', 'Kidney Calculi', 'Pregnancy', 'Pregnancy Complications', 'Retrospective Studies', 'Ureteral Calculi'] | 1,507,335 | [['M01.060.057'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.600.500', 'C12.777.967.249.500', 'C12.777.967.500.503', 'C13.351.968.419.600.500', 'C13.351.968.967.249.500', 'C13.351.968.967.500.503', 'C23.300.175.850.550'], ['G08.686.784.769'], ['C13.703'],... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Significance of bile leaks complicating conservative surgery for liver hydatidosis. | Hepatic hydatidosis presents a challenge in liver surgery, and there is still controversy regarding the appropriate surgical technique. A high incidence of postoperative bile leaks is reported as a significant disadvantage of conservative surgical procedures. The purpose of this study was to examine the incidence and c... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bile Ducts', 'Biliary Tract Diseases', 'Catheters, Indwelling', 'Digestive System Surgical Procedures', 'Echinococcosis, Hepatic', 'Female', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Sphincterotomy, Endoscopic'] | 12,053,223 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A03.159.183'], ['C06.130'], ['E07.132.500'], ['E04.210'], ['C01.610.335.190.396.314', 'C01.610.518.314', 'C06.552.664.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E04.210.120.850', 'E04.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prioritization of candidate genes for periodontitis using multiple computational tools. | BACKGROUND: Both genetic and environmental factors contribute to the development of periodontitis. Genetic studies identified a variety of candidate genes for periodontitis. The aim of the present study is to identify the most promising candidate genes for periodontitis using an integrative gene ranking method.METHODS:... | ['Computational Biology', 'Cytokines', 'Data Mining', 'Databases as Topic', 'Gene Expression Profiling', 'Genetic Association Studies', 'Humans', 'Interleukins', 'Matrix Metalloproteinases', 'Periodontitis', 'Tumor Necrosis Factors'] | 24,476,546 | [['H01.158.273.180', 'L01.313.124'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['L01.313.500.750.280.199', 'L01.470.625'], ['L01.313.500.750.300.188', 'L01.470.750'], ['E05.393.332'], ['E05.393.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465', 'D12.776.467.374.465', 'D23.529.3... | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Simultaneous determination of cefixime trihydrate and dicloxacillin sodium in pharmaceutical dosage form by reversed-phase high-performance liquid chromatography. | A simple, precise, accurate, and sensitive RP-HPLC method for simultaneous determination of cefixime trihydrate and dicloxacillin sodium in combined tablet dosage form was developed and validated. Chromatographic separation of the two drugs was performed on a Purospher BDS C18 column (25 cm x 4.6 mm id, 5 microm partic... | ['Buffers', 'Calibration', 'Cefixime', 'Chemistry, Pharmaceutical', 'Chromatography', 'Chromatography, High Pressure Liquid', 'Dicloxacillin', 'Dosage Forms', 'Dose-Response Relationship, Drug', 'Hydrogen-Ion Concentration', 'Particle Size', 'Phosphates', 'Reproducibility of Results', 'Tablets', 'Technology, Pharmaceut... | 20,480,900 | [['D27.720.470.280'], ['E05.978.155'], ['D02.065.589.099.249.190.190.115', 'D02.886.665.074.190.190.115', 'D03.633.100.300.249.190.190.115'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.181'], ['E05.196.181.400.300'], ['D02.065.589.099.750.625.150.205', 'D02.886.108.750.625.150.205', 'D03.633.100.300.750.625.150.205'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Similar Levels of Antimicrobial Resistance in U.S. Food Service Ground Beef Products with and without a "Raised without Antibiotics" Claim. | U.S. ground beef with "raised without antibiotics" (RWA) label claims are perceived as harboring fewer bacteria with antimicrobial resistance (AMR) than are found in conventional (CONV) ground beef with no such label claim. A total of 370 ground beef samples from CONV ( n = 191) and RWA ( n = 179) production systems we... | ['Animals', 'Anti-Bacterial Agents', 'Bacteria', 'Cattle', 'Drug Resistance, Bacterial', 'Escherichia coli', 'Meat Products', 'Microbial Sensitivity Tests', 'Phylogeny', 'Red Meat'] | 30,476,443 | [['B01.050'], ['D27.505.954.122.085'], ['B03'], ['B01.050.150.900.649.313.500.380.271'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G07.203.300.600.500', 'J02.500.600.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.697... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. | The molecular events regulating the elimination of cells to create a hollow lumen during tissue development are poorly understood. By using an in vitro morphogenesis model in which MCF-10A human mammary epithelial cells form hollow acini-like structures, we have observed both caspase-mediated apoptosis and autophagy as... | ['Apoptosis', 'Apoptosis Regulatory Proteins', 'Autophagy', 'Breast', 'Cell Line', 'Epithelial Cells', 'Female', 'Humans', 'In Vitro Techniques', 'Membrane Glycoproteins', 'Morphogenesis', 'Signal Transduction', 'TNF-Related Apoptosis-Inducing Ligand', 'Tumor Necrosis Factor-alpha'] | 14,993,595 | [['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['G04.011'], ['A01.236'], ['A11.251.210'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D12.776.395.550', 'D12.776.543.550'], ['G07.345.500'], ['G02.111.820', 'G04.835'], ['D12.644.276.374.750.625', 'D12.776.467.374.750.625', ... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Axial chordoma and parachordoma (soft tissue chordoma): two of a kind: report of two cases with primary diagnosis on fine-needle cytology samples. | This report concerns one case of sacrococcygeal chordoma and one case of parachordoma (soft-tissue chordoma) that were primarily diagnosed on fine-needle cytology (FNC) samples. Both neoplasms consisted of medium-sized epithelioid cells with eccentric, nucleolated nuclei, displaying abundant cytoplasm filled with bubbl... | ['Adult', 'Biopsy, Fine-Needle', 'Chordoma', 'Coccyx', 'Humans', 'Male', 'Middle Aged', 'Sacrum', 'Soft Tissue Neoplasms'] | 20,730,897 | [['M01.060.116'], ['E01.370.225.500.384.100.119.500', 'E01.370.225.998.054.119.500', 'E01.370.388.100.100.500', 'E04.074.119.500', 'E04.665.100.500', 'E05.200.500.384.100.119.500', 'E05.200.998.054.119.500', 'E05.242.384.100.119.500'], ['C04.557.465.220'], ['A02.835.232.834.229'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. | OBJECTIVES: Despite having potent activity against actively replicating Mycobacterium tuberculosis, isoniazid has very limited activity against dormant bacilli. In order to investigate the lack of bactericidal activity of this drug under conditions leading to mycobacterial dormancy, we studied the transcriptional patte... | ['Animals', 'Female', 'Gene Expression Regulation, Bacterial', 'Genes, Bacterial', 'Humans', 'Isoniazid', 'Mice', 'Mycobacterium tuberculosis', 'Tuberculosis'] | 18,156,607 | [['B01.050'], ['G05.308.300'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['B01.050.150.900.649.313.992.635.505.500'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Specific binding of Cu(II) ions by leucine-enkephalin analogs. | Results are reported from a potentiometric and spectroscopic (UV-visible, CD, and ESR) of the protonation constants and Cu(II)-complex stability constants of leucine enkephalin amide (H-Tyr-Gly-Gly-Phe-Leu-NH2, Leu-EN-amide) and two nitro analogs having 4-nitro substituent on the phenyl ring of the Phe residue, (H-Tyr-... | ['Amino Acid Sequence', 'Copper', 'Enkephalin, Leucine', 'Hydrogen-Ion Concentration', 'Molecular Sequence Data'] | 7,595,469 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D12.644.400.575.281.231', 'D12.776.631.650.575.281.231'], ['G02.300'], ['L01.453.245.667']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. | Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in depressed patients, and increase in response to antidepressant medication. However, how BDNF responds to different classes of antidepressa... | ['Adult', 'Antidepressive Agents', 'Brain-Derived Neurotrophic Factor', 'Citalopram', 'Cyclohexanols', 'Depressive Disorder, Major', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Sertraline', 'Severity of Illness Index', 'Treatment ... | 18,511,076 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D02.092.831.170', 'D02.626.320', 'D03.633.100.127.187'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['F03.600.300.375'], ['E05.478.566.350.170', 'E05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hydrogeological and biogeochemical constrains of arsenic mobilization in shallow aquifers from the Hetao basin, Inner Mongolia. | Little is known about the importance of drainage/irrigation channels and biogeochemical processes in arsenic distribution of shallow groundwaters from the Hetao basin. This investigation shows that although As concentrations are primarily dependent on reducing conditions, evaporation increases As concentration in the c... | ['Arsenic', 'Bacteria', 'China', 'Environmental Monitoring', 'Ferric Compounds', 'Fresh Water', 'Geologic Sediments', 'Oxidation-Reduction', 'Sulfates', 'Water Pollutants, Chemical', 'Water Supply'] | 21,277,054 | [['D01.268.513.249'], ['B03'], ['Z01.252.474.164'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.490.100'], ['G16.500.275.280', 'N06.230.232'], ['G01.311.330', 'G16.500.320'], ['G02.700', 'G03.295.531'], ['D01.248.497.158.845', 'D01.875.800.800.850'], ['D27.888.284.903.655'], ['J01.293.821.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
The effects of RU 41.740, a glycoprotein immunomodulating agent derived from Klebsiella pneumoniae, on intra-abdominal abscess formation in mice. | The prophylactic and therapeutic efficacies of the immunomodulating agent RU 41.740 (a glycoprotein extract from Klebsiella pneumoniae) were studied in a murine model of intra-abdominal abscess formation with Bacteroides fragilis, Escherichia coli, and bran as an abscess-potentiating agent. Parenteral injection of RU 4... | ['Abdomen', 'Abscess', 'Adjuvants, Immunologic', 'Animals', 'Bacterial Proteins', 'Glycoproteins', 'Klebsiella pneumoniae', 'Male', 'Mice', 'Mice, Inbred BALB C'] | 8,510,139 | [['A01.923.047'], ['C01.830.025', 'C23.550.470.756.100'], ['D27.505.696.477.067'], ['B01.050'], ['D12.776.097'], ['D09.400.430', 'D12.776.395'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.4... | ['Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pilot for novel context generalization paradigm. | BACKGROUND AND OBJECTIVES: Following an aversive experience, fears often generalize across contexts. Contextual fear generalization is modeled in a laboratory paradigm in which one context (CTX+) is paired with an aversive unconditional stimulus (US), while the other context (CTX-) is not. The current study sought to v... | ['Adult', 'Anxiety', 'Conditioning, Classical', 'Fear', 'Female', 'Generalization, Psychological', 'Humans', 'Male', 'Pilot Projects', 'Reflex, Startle', 'Stress, Psychological', 'Young Adult'] | 30,193,203 | [['M01.060.116'], ['F01.470.132'], ['F02.463.425.179.308'], ['F01.470.361'], ['F02.463.425.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E01.370.376.550.650.800', 'E01.370.600.550.650.800', 'F02.830.702.807', 'G11.561.731.869'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Examining Young Recreational Male Soccer Players' Experience in Adult- and Peer-Led Structures. | PURPOSE: Youth sport has the potential to be one of the healthiest and most beneficial activities in which children can partake. Participation in a combination of adult-led and peer-led sport structures appears to lead to favorable outcomes such as enhanced physical fitness, as well as social and emotional development.... | ['Adult', 'Canada', 'Child', 'Communication', 'Humans', 'Interpersonal Relations', 'Male', 'Peer Group', 'Physical Conditioning, Human', 'Pleasure', 'Soccer'] | 27,314,864 | [['M01.060.116'], ['Z01.107.567.176'], ['M01.060.406'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.829.316.483'], ['G11.427.410.698.277.311', 'I03.350.311'], ['F01.470.867', 'F02.830.816.492'], ['I03.450.642.845.800']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 |
Classification before regression for improving the accuracy of glucose quantification using absorption spectroscopy. | This work contributes to the improvement of glucose quantification using near-infrared (NIR), mid-infrared (MIR), and combination of NIR and MIR absorbance spectroscopy by classifying the spectral data prior to the application of regression models. Both manual and automated classification are presented based on three h... | ['Discriminant Analysis', 'Glucose', 'Glucose Clamp Technique', 'Humans', 'Hyperglycemia', 'Hypoglycemia', 'Principal Component Analysis', 'Spectroscopy, Near-Infrared'] | 32,070,580 | [['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['D09.947.875.359.448'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['C18.452.394.984'], ['E05.318.740.562'], ['E01.370.350.750', 'E05.196.867.851']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The parental craniofacial morphological features in Chinese patients with sporadic nonsyndromic cleft lip with or without palate. | OBJECTIVE: To evaluate the parental craniofacial morphology in Chinese patients with sporadic nonsyndromic cleft lip with or without palate.METHODS: A total of 98 parental pairs of nonsyndromic unilateral incomplete cleft lip children, 207 parental pairs of nonsyndromic complete cleft lip and palate children, and 206 n... | ['Adult', 'Case-Control Studies', 'Cephalometry', 'Child', 'China', 'Cleft Lip', 'Cleft Palate', 'Ethnic Groups', 'Fathers', 'Female', 'Humans', 'Male', 'Mandible', 'Maxilla', 'Middle Aged', 'Mothers', 'Nasal Bone', 'Palate', 'Parents', 'Skull Base', 'Vertical Dimension'] | 19,929,091 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['M01.060.406'], ['Z01.252.474.164'], ['C07.465.409.225', 'C07.465.525.164', 'C07.650.525.164', 'C16.131.850.525.164'], ['C05.500.460.185', 'C05.660.207.540... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders. | OBJECTIVE: The authors compared the effects of maintenance versus withdrawal of risperidone treatment in children and adolescents with symptoms of disruptive behavior disorder.METHOD: Patients with disruptive behavior disorder (5-17 years of age and a range of intellect) who had responded to risperidone treatment over ... | ['Adolescent', 'Age Factors', 'Antipsychotic Agents', 'Attention Deficit and Disruptive Behavior Disorders', 'Body Weight', 'Child', 'Child, Preschool', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Humans', 'Male', 'Placebos', 'Psychiatric Status Rating Scales', ... | 16,513,860 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F03.625.094'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['M01.060.406'], ['M01.060.406.448'],... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MIRAGE Syndrome: Phenotypic Rescue by Somatic Mutation and Selection. | MIRAGE syndrome, a multisystem disorder, results from heterozygous gain-of-function mutations in SAMD9, which encodes a growth suppressor, located on chromosome 7. Somatic changes involving loss-of-function mutations of the altered SAMD9 allele or loss of chromosome 7 act as phenotypic modifiers, providing a typical ex... | ['Adrenal Insufficiency', 'Genetic Diseases, Inborn', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Mutation', 'Phenotype'] | 31,624,021 | [['C19.053.500'], ['C16.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['G05.365.590'], ['G05.695']] | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Histopathologic study of islets of Langerhans in patients after gastrectomy. | In autopsy specimens removed after gastrectomy from patients who had survived for 2.5 to 40 years after surgery, we found hyalinization of the islets of Langerhans in 9 of 15 cases (60%) with Billroth's I anastomosis (B-I) and in 8 of 16 cases (50%) with Billroth's II anastomosis (B-II). The hyalinization in the postga... | ['Aged', 'Aged, 80 and over', 'Amyloid', 'Female', 'Gastrectomy', 'Humans', 'Hyalin', 'Islets of Langerhans', 'Male', 'Middle Aged', 'Time Factors'] | 9,412,976 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D05.500.049', 'D12.776.049'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.580'], ['A03.734.414', 'A06.300.414'], ['M01.060.116.630'], ['G01.910.857']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The structure of r(UUCGCG) has a 5'-UU-overhang exhibiting Hoogsteen-like trans U.U base pairs. | The crystal structure of the RNA fragment, 5'-r(UUCGCG)-3', has been determined at 1.4 A resolution by a combination of single isomorphous replacement and molecular search methods. The 3'-terminal CGCG portion of the hexamer engages in Watson-Crick hydrogen bonding while the 5'-terminal UU-overhang forms novel Hoogstee... | ['Animals', 'Base Composition', 'Base Sequence', 'Crystallography, X-Ray', 'Hydrogen Bonding', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Polymorphism, Genetic', 'RNA'] | 8,548,450 | [['B01.050'], ['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.309.742.225'], ['G02.282'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['G05.365.795'], ['D13.444.735']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A. | The ectodomain of influenza A matrix protein 2 (M2e) is a candidate for a universal influenza A vaccine. We used recombinant Hepatitis B core antigen to produce virus-like particles presenting M2e (M2e-VLPs). We produced the VLPs with and without entrapped nucleic acids and compared their immunogenicity and protective ... | ['Adaptive Immunity', 'Adaptor Proteins, Vesicular Transport', 'Animals', 'Female', 'Humans', 'Immunity, Cellular', 'Influenza A Virus, H3N2 Subtype', 'Influenza Vaccines', 'Influenza, Human', 'Lung', 'Mice', 'Myeloid Differentiation Factor 88', 'Orthomyxoviridae Infections', 'RNA', 'Signal Transduction', 'Th1 Cells', ... | 23,527,091 | [['G12.450.050'], ['D12.776.543.990.150'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['B04.820.480.968.405.400.300'], ['D20.215.894.899.302'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.644.360.024.311',... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis. | BACKGROUND/AIMS: Understanding the mechanism that involves in regulating epithelial cells renewal is the fundamental of regulating intestinal mucosa development and functions and related diseases. The mechanistic target of rapamycin (mTOR) signaling pathway involves in controlling various major processes by integrating... | ['Animals', 'Animals, Suckling', 'Blotting, Western', 'Cell Cycle Proteins', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Cluster Analysis', 'Epithelial Cells', 'Intestinal Mucosa', 'Jejunum', 'Microvilli', 'Proteome', 'Proteomics', 'Signal Transduction', 'Swine', 'TOR Serine-Threonine Kinases'] | 27,459,644 | [['B01.050'], ['B01.050.050.293'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.167'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['A11.436'], ['A03.556.124.369', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Interleukin-2 plus chemotherapy for patients with metastatic melanoma. | We studied the activity of recombinant interleukin-2 (IL2) in combination with multiagent chemotherapy in the treatment of patients with disseminated malignant melanoma. Patients were randomized to receive the same dose of lymphokine by constant 24 h intravenous infusion (CI) or by subcutaneous bolus (SB) injection. Tw... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Bleomycin', 'Cisplatin', 'Combined Modality Therapy', 'Female', 'Humans', 'Infusions, Intravenous', 'Injections, Subcutaneous', 'Interleukin-2', 'Lomustine', 'Male', 'Melanoma', 'Middle Aged', 'Recombinant Proteins', 'Remission Induction', 'Skin Neopl... | 10,890,384 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D09.400.420.110', 'D12.644.233.110'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E02.319.267.530.620'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk of misdiagnosis, health-related quality of life, and BMI in patients who are overweight with doctor-diagnosed asthma. | BACKGROUND: Obesity and asthma both cause breathlessness, and there is a risk of misdiagnosis of asthma in patients who are obese. Impaired health-related quality of life (HRQoL) and increased BMI increase physician attendance rates, increasing this risk. We explored the possibility of misdiagnosis and the relationship... | ['Adult', 'Asthma', 'Body Mass Index', 'Bronchodilator Agents', 'Comorbidity', 'Diagnostic Errors', 'Female', 'Health Surveys', 'Humans', 'Lung', 'Male', 'Middle Aged', 'Overweight', 'Quality of Life', 'Respiratory Function Tests', 'Risk Factors', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 21,868,466 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['N05.715.350.225', 'N06.850.490.687'], ['E01.354', 'N02.421.450.280'], ['E05.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging. | CONTEXT: Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural system effects that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophrenia before and after pharmacotherapy can enhance understanding of the therapeutic... | ['Adult', 'Antipsychotic Agents', 'Brain', 'Brain Mapping', 'Case-Control Studies', 'Echo-Planar Imaging', 'Female', 'Functional Laterality', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Nerve Net', 'Neural Pathways', 'Oxygen', 'Parietal Lobe', 'Rest', 'Risperidone', 'Schizophrenia'] | 20,679,586 | [['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.350.825.500.200'], ['F02.830.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells. | In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vime... | ['Animals', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Proliferation', 'Epithelial-Mesenchymal Transition', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Lung Neoplasms', 'Mice', 'Mixed Function Oxygenases', 'Neoplasm Invasiveness', 'Neoplasm Metastasis', 'Proto-Oncogene Proteins', 'Smad2 Protein', 'Vimentin', '... | 26,931,431 | [['B01.050'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.356.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['D08.811.682.690.708'], ['C04... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Guide wire angioplasty balloon catheter: preliminary report. | A new balloon catheter has been developed for angioplasty. The balloon is more flexible and its walls are thinner than those of conventional catheters. It folds down better yet withstands 8-10 atm of pressure. This advance has been married to new guide wire technology, producing a low-profile angioplasty balloon on a 0... | ['Angioplasty, Balloon', 'Constriction, Pathologic', 'Humans', 'Vascular Diseases'] | 2,971,235 | [['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['C23.300.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cystic fibrosis screening: a fetus with hyperechogenic bowel may be the index case. | BACKGROUND: The potential of hyperechogenic fetal bowel to act as a hallmark for prenatal cystic fibrosis screening in the general population is controversial.METHODS: Our goal was to evaluate the incidence of cystic fibrosis in 209 fetuses with hyperechogenic bowel diagnosed at routine ultrasonography and with no fami... | ['Cystic Fibrosis', 'Cystic Fibrosis Transmembrane Conductance Regulator', 'Female', 'Follow-Up Studies', 'Genetic Testing', 'Humans', 'Incidence', 'Intestines', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Outcome', 'Prospective Studies', 'Ultrasonography, Prenatal'] | 9,719,372 | [['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['D12.776.157.530.100.304.500', 'D12.776.157.530.400.175.125', 'D12.776.157.530.450.074.500.500.500.500', 'D12.776.543.550.450.175.125', 'D12.776.543.585.100.304.500', 'D12.776.543.585.400.175.125', 'D12.776.543.585.450.074.500.500.500.500'], ['E05.318.372.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity. | BACKGROUND: There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little is known about the impact of obesity on epigenetic aging of metabolically active visceral adipose tissue (VAT). Herein, we aimed to test whe... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biliopancreatic Diversion', 'Body Mass Index', 'DNA Methylation', 'Epigenesis, Genetic', 'Female', 'Humans', 'Intra-Abdominal Fat', 'Logistic Models', 'Male', 'Middle Aged', 'Obesity', 'Young Adult'] | 31,791,395 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210.120.086', 'E04.210.169'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G05.308.203'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pathological narcissism and depressive symptoms in psychiatric outpatients: mediating role of dysfunctional attitudes. | OBJECTIVE: The aim of this study was to examine the relationships between pathological narcissism (narcissistic grandiosity and narcissistic vulnerability), dysfunctional attitudes (perfectionism and dependency on other people), and depressive symptoms in psychiatric outpatients.METHOD: A sample of 234 adult psychiatri... | ['Adult', 'Attitude', 'Depression', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Narcissism', 'Outpatients', 'Personality Disorders'] | 23,996,163 | [['M01.060.116'], ['F01.100'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['F02.739.794.582'], ['M01.643.630'], ['F03.675']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Experimental infections with pathogenic free-living amebae in laboratory primate hosts: I. (B) A study on susceptibility to Acanthamoeba culbertsoni. | Susceptibility to A. culbertsoni was studied in 15 Old World monkeys by intranasal, intravenous, or intrathecal inoculation of trophozoites. No clinically detectable disease resulted from either intranasal or intravenous inoculation, but 4 of 7 monkeys inoculated intrathecally succumbed to acutely fatal meningoencephal... | ['Amebiasis', 'Amoeba', 'Animals', 'Disease Models, Animal', 'Female', 'Macaca', 'Male', 'Mice', 'Monkey Diseases', 'Virulence'] | 1,165,552 | [['C01.610.752.049'], ['B01.046.500.100.700.089'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['B01.050.150.900.649.313.992.635.505.500'], ['C22.735.500'], ['G06.930']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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