Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Ethanol-induced lowering of arterial oxyhemoglobin saturation during hypoxia. | Nine fasting, healthy, adult male volunteers were given oral carbohydrate before exposures to normoxia (PIO2 = 149 torr) and mild hypoxia (PIO2 = 98 torr). Following recovery, they were given oral ethanol before similar exposure to normoxia and mild hypoxia. Repeated measures of arterial blood and expired gases were ma... | ['Administration, Oral', 'Adult', 'Carbohydrate Metabolism', 'Carbon Dioxide', 'Depression, Chemical', 'Ethanol', 'Fats', 'Hemoglobins', 'Humans', 'Hypoxia', 'Male', 'Oxygen', 'Oxygen Consumption', 'Oxyhemoglobins', 'Spirometry', 'Ventilation-Perfusion Ratio'] | 1,164,347 | [['E02.319.267.100'], ['M01.060.116'], ['G02.111.158', 'G03.191'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G07.690.773.750'], ['D02.033.375'], ['D10.212'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['D01.268.185.550', 'D01.362.670'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The dose-dependent tumor targeting of antibody-IFNã fusion proteins reveals an unexpected receptor-trapping mechanism in vivo. | Cytokines often display substantial toxicities at low concentrations, preventing their escalation for therapeutic treatment of cancer. Fusion proteins comprising cytokines and recombinant antibodies may improve the anticancer activity of proinflammatory cytokines. Murine IFNã was appended in the diabody format at the C... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Antibodies, Neoplasm', 'Antineoplastic Agents', 'Biological Availability', 'Biomarkers, Tumor', 'Cricetinae', 'Dose-Response Relationship, Immunologic', 'Female', 'Fibronectins', 'Interferon-gamma', 'Male', 'Mice, Inbred C57BL', 'Neoplasms', 'R... | 24,795,141 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D12.776.124.486.485.114.240', 'D12.776.124.790.651.114.240', 'D12.776.377.715.548.114.240'], ['D27.505... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sertoli cells promote proliferation of bone marrow-derived mesenchymal stem cells in co-culture. | Bone marrow-derived mesenchymal stem cells (BMSCs) are a major source for cell transplantation. The proliferative ability of BMSCs is an important determinant of the efficiency of transplant therapy. Sertoli cells are "nurse" cells for development of sperm cells. Our recent study showed that Sertoli cells promoted prol... | ['Animals', 'Cell Cycle Proteins', 'Cell Proliferation', 'Cells, Cultured', 'Coculture Techniques', 'Gene Expression Regulation', 'Male', 'Mesenchymal Stem Cells', 'Mice', 'Paracrine Communication', 'RNA, Messenger', 'Sertoli Cells', 'Signal Transduction'] | 27,319,049 | [['B01.050'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['E05.481.500.374'], ['G05.308'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['G04.085.600'], ['D13.444.735.544'], ['A05.360.444.849.789', 'A11.382.952', 'A11.436.837'], ['G02.111.820', 'G04.835... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Fatal diltiazem poisoning]. | The diagnosis at postmortem examination and the results of the chemical analysis in a case of a diltiazem intoxication are presented. Two metabolites were identified as desacetyldiltiazem and N-desmethyldiltiazem. | ['Alcoholism', 'Biotransformation', 'Diltiazem', 'Ethanol', 'Humans', 'Male', 'Middle Aged', 'Suicide', 'Tissue Distribution'] | 3,176,717 | [['C25.775.100.250', 'F03.900.100.350'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D03.633.100.079.150'], ['D02.033.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.126.980.875', 'I01.880.735.856'], ['G03.787.917', 'G07.690.725.949']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
DSM-III compulsive personality disorder: an epidemiological survey. | A two-stage probability sample of community subjects was developed with a full psychiatric examination employing DSM-III criteria in conjunction with the Epidemiological Catchment Area (ECA) survey conducted in Baltimore, MD. This report details the observation on those subjects diagnosed with compulsive personality di... | ['Adolescent', 'Adult', 'Baltimore', 'Cross-Sectional Studies', 'Female', 'Humans', 'Incidence', 'Life Change Events', 'Male', 'Middle Aged', 'Obsessive-Compulsive Disorder', 'Psychiatric Status Rating Scales'] | 1,876,651 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.567.875.500.500.100', 'Z01.433.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.37... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways. | It has long been recognized that anatomic location is an important feature for defining distinct subtypes of plaque psoriasis. However, little is known about the molecular differences between scalp, palmoplantar, and conventional plaque psoriasis. To investigate the molecular heterogeneity of these psoriasis subtypes, ... | ['Adult', 'Aged', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cluster Analysis', 'Cytokines', 'Female', 'Flow Cytometry', 'Gene Expression Profiling', 'Gene Regulatory Networks', 'Humans', 'Male', 'Middle Aged', 'Principal Component Analysis', 'Psoriasis', 'Scalp', 'Sequence Analysis, RNA', 'Signal Tra... | 30,054,515 | [['M01.060.116'], ['M01.060.116.100'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D12.644.276.37... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maternal perceptions of BRCA genetic counseling communication processes about disclosing cancer risk information to children and adult relatives. | OBJECTIVES: Using a novel measure, examine maternal perceptions of the process by which issues pertaining to family communication of BRCA test results are addressed during cancer genetic counseling.METHODS: After receiving BRCA results, mothers (N = 211) of minor-age children reported on their counseling experiences wi... | ['Adolescent', 'Adult', 'Breast Neoplasms', 'Child', 'Decision Making', 'Disclosure', 'Female', 'Genetic Counseling', 'Genetic Predisposition to Disease', 'Genetic Testing', 'Humans', 'Middle Aged', 'Mother-Child Relations', 'Ovarian Neoplasms'] | 29,645,321 | [['M01.060.057'], ['M01.060.116'], ['C04.588.180', 'C17.800.090.500'], ['M01.060.406'], ['F02.463.785.373'], ['F01.829.401.046', 'I01.880.604.583.080.134', 'L01.143.335'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['C23.550.291.687.500', 'G05.380.355'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.4... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'O... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Effects of fluticasone propionate, triamcinolone acetonide, prednisone, and placebo on the hypothalamic-pituitary-adrenal axis. | BACKGROUND: Many clinicians are reluctant to prescribe inhaled corticosteroids because of concerns over potential effects on the hypothalamic-pituitary-adrenal axis.OBJECTIVE: The purpose of this study was to compare the adrenal responses to 6-hour cosyntropin infusion after treatment with fluticasone propionate aeroso... | ['Administration, Inhalation', 'Adolescent', 'Adult', 'Androstadienes', 'Anti-Inflammatory Agents', 'Asthma', 'Cosyntropin', 'Double-Blind Method', 'Female', 'Fluticasone', 'Humans', 'Hydrocortisone', 'Hypothalamo-Hypophyseal System', 'Male', 'Middle Aged', 'Pituitary-Adrenal System', 'Prednisone', 'Time Factors', 'Tri... | 10,200,011 | [['E02.319.267.050'], ['M01.060.057'], ['M01.060.116'], ['D04.210.500.054.079.129'], ['D27.505.954.158'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D06.472.699.327.935.531.500.200', 'D06.472.699.631.525.600.531.500.200', 'D12.644.400.400.935.531.500.200', 'D12.644.548.365.935.531.500.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A longitudinal clinical comparison of plaque-induced inflammation between gingival and peri-implant soft tissues in the maxilla. | BACKGROUND: Little information exists concerning the periimplant soft tissue response to plaque compared to the gingiva of the dentition. The purpose of this study was to compare this relative tissue response to plaque in humans over time.METHODS: Two hundred seventy-five (275) hydroxyapatite-coated implants were place... | ['Adult', 'Aged', 'Chi-Square Distribution', 'Coated Materials, Biocompatible', 'Dental Implantation, Endosseous', 'Dental Implants', 'Dental Plaque', 'Dental Plaque Index', 'Dental Prosthesis Design', 'Durapatite', 'Female', 'Gingivitis', 'Humans', 'Linear Models', 'Male', 'Maxilla', 'Middle Aged', 'Periodontal Index'... | 11,577,943 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D25.130.420', 'J01.637.051.130.420'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Prognostic value of miR-29a expression in pediatric acute myeloid leukemia. | OBJECTIVES: As a member of miR-29 family, miR-29a can act as either oncogene or tumor suppressor. However, its expression patterns in acute myeloid leukemia (AML) are controversial according to previous studies. Thus, the aim of this study was to determine the expression and clinical significance of miR-29a in pediatri... | ['Bone Marrow Cells', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Female', 'Gene Expression Regulation, Leukemic', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'MicroRNAs', 'Predictive Value of Tests', 'Prognosis', 'Proportional Hazards Models', 'Reference Values', 'Survival Analysis', 'Treatment Outcome'] | 22,981,932 | [['A11.148', 'A15.378.316'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['G05.308.370.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E05.31... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Young adults admitted for asthma: does gender influence outcomes? | OBJECTIVE: To assess any outcome differences between young men and women who are admitted for asthma.METHODS: We conducted a retrospective cohort study based on hospitalizations. An inclusion criterion was admission for asthma between January 1, 1998 and July 1, 2001. Exclusion criteria included age >45, chronic obstru... | ['Adolescent', 'Adult', 'Asthma', 'Cohort Studies', 'Demography', 'Female', 'Hospital Mortality', 'Hospitalization', 'Hospitals, Urban', 'Humans', 'Length of Stay', 'Male', 'Ohio', 'Respiratory Care Units', 'Respiratory Insufficiency', 'Retrospective Studies', 'Sex Factors', 'Treatment Outcome'] | 12,869,295 | [['M01.060.057'], ['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.85... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Contribution of cardiac and arterial baroreceptors to enhanced vasopressin release during hemorrhage with autonomic blockade. | During episodes of blood loss, several apparently redundant mechanisms are activated to maintain arterial blood pressure. This study was designed to examine one such compensatory mechanism involving enhanced vasopressin release during hemorrhage when the autonomic nervous system (ANS) is pharmacologically blocked. Firs... | ['Afferent Pathways', 'Animals', 'Arginine Vasopressin', 'Autonomic Nervous System', 'Blood Pressure', 'Cardiac Output', 'Denervation', 'Dogs', 'Female', 'Heart', 'Heart Rate', 'Hemorrhage', 'Hexamethonium', 'N-Methylscopolamine', 'Norepinephrine', 'Pressoreceptors', 'Reference Values', 'Renin', 'Scopolamine Derivative... | 7,700,884 | [['A08.612.220'], ['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['A08.800.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E04.525.210'], ['B01.050.150.900.649.313.750.... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New isostructural transition metal complexes with a non-innocent dithiolate ligand. | Three new complexes with 3,6-dichlorobenzene-1,2-dithiol (bdtCl2), namely methyltriphenylphosphonium bis(3,6-dichlorobenzene-1,2-dithiolato-ê(2)S,S')cobaltate(1-), (C19H18P)[Co(C6H2Cl2S2)2], (I), bis(methyltriphenylphosphonium) bis(3,6-dichlorobenzene-1,2-dithiolato-ê(2)S,S')cuprate(2-) dimethyl sulfoxide disolvate, (C... | ['Coordination Complexes', 'Copper', 'Crystallography, X-Ray', 'Ligands', 'Metals', 'Sulfhydryl Compounds'] | 25,652,286 | [['D01.234', 'D02.257'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.309.742.225'], ['D27.720.470.480'], ['D01.552'], ['D02.886.489']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biogenesis of L-glyceric aciduria, oxalosis and renal injury in rats simulating type II primary hyperoxaluria. | Tracer experiments in rats mimicking type II primary hyperoxaluria, with an expanded intracellular pool of hydroxypyruvate, showed that the excess formation of oxalate did not originate from its immediate precursor glyoxylate. In these animals, the hepatic and kidney activities of oxalate synthesising enzymes such as l... | ['Animals', 'Glyceric Acids', 'Glyoxylates', 'Hyperoxaluria', 'Kidney Diseases', 'L-Lactate Dehydrogenase', 'Lipid Peroxides', 'Liver', 'Male', 'Oxalates', 'Oxalic Acid', 'Rats', 'Rats, Wistar'] | 9,540,839 | [['B01.050'], ['D02.241.081.844.387', 'D02.241.511.902.387', 'D09.811.366'], ['D02.241.152.367'], ['C12.777.419.313', 'C13.351.968.419.313'], ['C12.777.419', 'C13.351.968.419'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An assessment of the potential of laser-induced breakdown spectroscopy (LIBS) for the analysis of cesium in liquid samples of biological origin. | The present study describes the development of an analytical method for the determination of cesium in biological fluid samples (human urine and blood samples) by laser-induced breakdown spectroscopy (LIBS). The developed method is based on sample presentation by liquid-to-solid conversion, enhancing the emission signa... | ['Blood Chemical Analysis', 'Calibration', 'Cesium', 'Cesium Radioisotopes', 'Chlorides', 'Environmental Monitoring', 'Equipment Design', 'Humans', 'Lasers', 'Plasma', 'Radioactive Hazard Release', 'Radioactive Pollutants', 'Reference Standards', 'Safety Management', 'Specimen Handling', 'Spectrophotometry, Atomic', 'U... | 25,014,845 | [['E01.370.225.124.100', 'E05.200.124.100'], ['E05.978.155'], ['D01.268.549.125', 'D01.268.556.165', 'D01.552.528.160', 'D01.552.544.165'], ['D01.268.549.125.500.300', 'D01.268.556.165.500.300', 'D01.496.180.300', 'D01.496.749.190', 'D01.552.528.160.500.300', 'D01.552.544.165.500.300'], ['D01.210.450.150', 'D01.248.497... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism. | PURPOSE: The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. MATERIAL METHOD(S): Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the ... | ['Adult', 'Anti-Mullerian Hormone', 'Female', 'Fertilization in Vitro', 'Gonadotropins', 'Humans', 'Hypogonadism', 'Ovarian Follicle', 'Ovary', 'Ovulation Induction', 'Pregnancy', 'Prospective Studies'] | 22,547,042 | [['M01.060.116'], ['D06.472.334.984.500', 'D09.400.430.625', 'D12.776.395.089'], ['E02.875.800.750', 'E05.820.800.750'], ['D06.472.699.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.391.482'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains. | Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in ... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Brain', 'Cysteine Endopeptidases', 'Female', 'Gene Expression Regulation, Enzymologic', 'Humans', 'In Situ Hybridization', 'Male', 'RNA, Messenger'] | 10,686,410 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['A08.186.211'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['G05.308.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Health visitor risk assessment for preventing falls in elderly people. | This study was undertaken to look at the feasibility of a health visitor risk assessment for falls at the time of the routine health check for people aged 75 years and above. A total of 162 people were eligible for inclusion in the study. The standard over-75 assessment check was carried out either in the GP surgery or... | ['Accidental Falls', 'Age Factors', 'Aged', 'Female', 'Humans', 'Male', 'Office Visits', 'Risk Assessment'] | 11,904,560 | [['N06.850.135.122'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.758.635'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715']] | ['Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Pathological and endocrinological study of epithelial ovarian tumors in post-menopausal women]. | We have studied 37 cases of ovarian epithelial tumors in post-menopausal women, histopathologically and endocrinologically. The normal values for androstenedione, estrone, estradiol and progesterone in healthy post-menopausal women were less than 83 ng/dl, 75 pg/ml, 30 pg/ml and 0.6 ng/ml, respectively. The numbers of ... | ['Adenocarcinoma', 'Aged', 'Androstenedione', 'Cystadenocarcinoma', 'Cystadenoma', 'Estradiol', 'Estrone', 'Female', 'Gonadal Steroid Hormones', 'Humans', 'Middle Aged', 'Ovarian Neoplasms'] | 3,722,949 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['C04.557.470.200.025.480', 'C04.557.470.590.480'], ['C04.557.470.035.320', 'C04.557.470.590.485'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D04.210.5... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Suture contamination in strabismus surgery. | PURPOSE: To document the contamination rate of sutures used in strabismus surgery and evaluate the reduction of contamination using antibiotic-coated and antiseptic/antibiotic-coated sutures.METHODS: This was a prospective randomized analysis of suture contamination and potential prophylaxis measures after strabismus s... | ['Adult', 'Anti-Infective Agents, Local', 'Coated Materials, Biocompatible', 'Disinfection', 'Drug Combinations', 'Endophthalmitis', 'Equipment Contamination', 'Eye Infections, Bacterial', 'Female', 'Fluprednisolone', 'Humans', 'Neomycin', 'Oculomotor Muscles', 'Polyglactin 910', 'Polymyxin B', 'Povidone-Iodine', 'Pros... | 22,909,077 | [['M01.060.116'], ['D27.505.954.122.187'], ['D25.130.420', 'J01.637.051.130.420'], ['N06.850.780.200.450.850.375'], ['D26.310'], ['C01.375.265', 'C11.294.265'], ['N06.850.540'], ['C01.150.252.289', 'C01.375.354', 'C11.294.354'], ['D04.210.500.745.432.769.795.307', 'D04.210.500.908.502'], ['B01.050.150.900.649.313.988.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Determination of lymphocyte subpopulations, defined with monoclonal antibodies, in patients with iron deficiency anemia]. | Lymphocytary subpopulations have been determined, by means of monoclonal antibodies, in 24 patients afflicted with iron deficient anaemia, repeating the determination in 15 of the patients after an adequate iron therapy. In iron deficient patients a significant reduction of the percentage of lymphocytes T (OKT3+) has b... | ['Adolescent', 'Adult', 'Aged', 'Anemia, Hypochromic', 'Antibodies, Monoclonal', 'CD4-CD8 Ratio', 'Female', 'Humans', 'Leukocyte Count', 'Male', 'Middle Aged', 'T-Lymphocyte Subsets'] | 1,945,004 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C15.378.071.196'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E01.370.225.500.195.107.595.500.150.160', 'E01.370.225.625.107.595.500.150.160', 'E05.200.500.195.107.595.500.150.160', 'E05.200.625.107.595.500.1... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fate of asialofetuin endocytosed by rat liver. | We have investigated the endocytosis by rat liver of asialofetuin coupled to [125I] tyramine cellobiose: [125I] TCASF. Subcellular distribution of radioactive compounds was established after differential and isopycnic centrifugation and by analysing the fractions by SDS electrophoresis. Labelling secondary lysosomes wa... | ['Alkaline Phosphatase', 'Animals', 'Asialoglycoproteins', 'Cathepsin C', 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'Endocytosis', 'Fetuins', 'Iodine Radioisotopes', 'Liver', 'Male', 'Mitochondria, Liver', 'Organelles', 'Rats', 'Rats, Inbred Strains', 'Subcellular Fractions', 'alpha-Fetoproteins'] | 2,463,836 | [['D08.811.277.352.650.035'], ['B01.050'], ['D12.776.395.140'], ['D08.811.277.656.224.130', 'D08.811.277.656.262.186', 'D08.811.277.656.350.350.100'], ['D08.811.277.656.350.350'], ['G04.417'], ['D12.776.124.790.106.304', 'D12.776.157.125.283', 'D12.776.215.625', 'D12.776.377.715.085.304'], ['D01.268.380.400.500.496', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endolymphatic hydrops in asymptomatic ears in unilateral M?ni?re's disease. | OBJECTIVES/HYPOTHESIS: The aim of our study was the objective assessment of endolymphatic hydrops in asymptomatic ears in unilateral M?ni?re's disease with a noninvasive electrophysiological test and investigation of significant clinical signs. The null hypothesis was that there would be no signs of endolymphatic hydro... | ['Endolymphatic Hydrops', 'Evoked Potentials, Auditory, Brain Stem', 'Female', 'Humans', 'Male', 'Meniere Disease', 'Prospective Studies'] | 11,359,166 | [['C09.218.568.217'], ['G07.265.216.500.370.300', 'G07.888.250.300', 'G11.561.200.500.370.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.568.217.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The relationship of modern health worries to depression, symptom reporting and quality of life in a general population survey. | OBJECTIVE: Worries about the risk to personal health from new technology and features of modern life have been shown to be associated with the use of health care services, health behaviours, mood and reporting of physical symptoms. We examined the frequency and nature of these concerns in a large national sample and th... | ['Adult', 'Aged', 'Anxiety Disorders', 'Attitude to Health', 'Cross-Sectional Studies', 'Depressive Disorder', 'Female', 'Germany', 'Health Surveys', 'Humans', 'Illness Behavior', 'Male', 'Middle Aged', 'Personality Inventory', 'Quality of Life', 'Risk Factors', 'Sex Factors', 'Social Change', 'Socioeconomic Factors', ... | 22,405,228 | [['M01.060.116'], ['M01.060.116.100'], ['F03.080'], ['F01.100.150', 'N05.300.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F03.600.300'], ['Z01.542.315'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of dopamine and dobutamine on hyperoxic and hypoxic pulmonary vascular tone in dogs. | The pulmonary vascular effects of dopamine and of dobutamine have been reported variably in the literature. We investigated the effects of dopamine and of dobutamine, at doses of 10 and 20 micrograms/kg/min, on the relationships of overall mean pulmonary arterial pressure (Ppa) to cardiac index (Cl) in 14 dogs ventilat... | ['Animals', 'Blood Gas Analysis', 'Dobutamine', 'Dogs', 'Dopamine', 'Dose-Response Relationship, Drug', 'Hemodynamics', 'Hypoxia', 'Lung', 'Oxygen', 'Pulmonary Circulation', 'Vascular Resistance', 'Vasoconstriction'] | 3,605,836 | [['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D02.092.311.220', 'D02.092.471.683.410', 'D02.455.426.559.389.657.166.175.220'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['G07.690.773.875', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids. | Drugs capable of specifically recognizing and killing cancer cells while sparing healthy cells are of great interest in anti-cancer therapy. An example of such a drug is edelfosine, the prototype molecule of a family of synthetic lipids collectively known as antitumor lipids (ATLs). A better understanding of the select... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Caenorhabditis elegans', 'Cell Line, Tumor', 'Cholesterol', 'Drug Resistance', 'Embryo, Nonmammalian', 'Embryonic Development', 'Humans', 'Insulin-Like Growth Factor I', 'Larva', 'Membrane Microdomains', 'Phospholipid Ethers', 'Phosphorylcholine'] | 25,485,582 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['B01.050.500.500.294.400.875.660.250.250'], ['A11.251.210.190', 'A11.251.860.180'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.690.773.984'], ['A13.350', 'A16.331'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['B01.050.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Combining intensity, edge and shape information for 2D and 3D segmentation of cell nuclei in tissue sections. | We present a region-based segmentation method in which seeds representing both object and background pixels are created by combining morphological filtering of both the original image and the gradient magnitude of the image. The seeds are then used as starting points for watershed segmentation of the gradient magnitude... | ['Automation', 'Cell Nucleus', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Microscopy, Fluorescence', 'Sensitivity and Specificity', 'Uterine Cervical Neoplasms'] | 15,230,877 | [['J01.897.104'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.515.458', 'E05.595.458'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], [... | ['Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Direct binding and functional studies on muscarinic cholinoceptors in porcine coronary artery. | The muscarinic cholinoceptors in porcine coronary artery were identified and characterized by a binding assay using (-)-[3H]quinuclidinyl benzilate (QNB) and also by pharmacological method. Specific (-)-[3H]QNB binding in the coronary artery was saturable and of high affinity (Kd = 0.08 nM), and it showed a pharmacolog... | ['Acetylcholine', 'Animals', 'Binding Sites', 'Coronary Vessels', 'Endothelium, Vascular', 'Female', 'In Vitro Techniques', 'Male', 'Quinuclidinyl Benzilate', 'Receptors, Muscarinic', 'Swine', 'Vasoconstriction'] | 2,313,599 | [['D02.092.211.111'], ['B01.050'], ['G02.111.570.120'], ['A07.015.114.269', 'A07.015.908.194'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.481'], ['D02.241.223.601.238.306.740', 'D02.241.511.085.740', 'D03.605.687.800'], ['D12.776.543.750.695.475', 'D12.776.543.750.720.360.500'], ['B01.050.150.900.649.313.500.880'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of immediate-early transcripts of equine cytomegalovirus. | Equine cytomegalovirus (ECMV) contains a linear, double-stranded DNA genome composed of a 146-kbp unique region flanked by a pair of 18-kbp direct repeat (DR) sequences at the termini. Cycloheximide, actinomycin D, and phosphonoacetic acid were applied to infected cell cultures to divide viral transcription into immedi... | ['Antigens, Viral', 'Blotting, Northern', 'Cell Line', 'Cytomegalovirus', 'Genes, Viral', 'Immediate-Early Proteins', 'Protein Precursors', 'Restriction Mapping', 'Transcription, Genetic'] | 1,310,181 | [['D23.050.327'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A11.251.210'], ['B04.280.382.150.150'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['D12.776.460', 'D12.776.964.925.968'], ['D12.776.811'], ['E05.393.183.620.650', 'E05.393.712'], ['G02.111.873', 'G05.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical features and epidemiological survey of perianal warts in 72 males]. | OBJECTIVE: To investigate the clinical features and epidemiological data of 72 cases of male perianal warts.METHODS: Seventy-two cases of perianal warts in our clinic dated from June, 2004 to April, 2006 were enrolled in the study, whose clinical information and epidemiological data were collected and analyzed.RESULTS:... | ['Adolescent', 'Adult', 'Anus Diseases', 'Condylomata Acuminata', 'Humans', 'Male', 'Middle Aged'] | 17,121,025 | [['M01.060.057'], ['M01.060.116'], ['C06.405.469.860.101'], ['C01.221.812.640.220', 'C01.778.640.220', 'C01.925.256.650.810.217', 'C01.925.813.220', 'C01.925.825.810.110', 'C01.925.928.914.217', 'C17.800.838.790.810.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Preservation and phallotoxin-staining of the microfilament system in Amoeba proteus. | The spatial organization of the microfilament system as the main component of the cytoskeleton in Amoeba proteus was preserved by a glutaraldehyde-lysine-fixation and visualized with fluorescent phallotoxins (NBD- phallacidin , R-phalloidin). Results obtained by means of this method coincide exactly with observations g... | ['Amanitins', 'Amoeba', 'Animals', 'Cytoskeleton', 'Fixatives', 'Microscopy, Fluorescence', 'Staining and Labeling'] | 6,202,428 | [['D04.345.566.050', 'D12.644.456.050', 'D12.644.641.050', 'D23.946.587.175'], ['B01.046.500.100.700.089'], ['B01.050'], ['A11.284.430.214.190.750'], ['D27.720.355'], ['E01.370.350.515.458', 'E05.595.458'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.750.600.670']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence and spatial distribution of Entamoeba histolytica/dispar and Giardia lamblia among schoolchildren in Agboville area (C?te d'Ivoire). | BACKGROUND: New efforts are being made to improve understanding of the epidemiology of the helminths and intensifying the control efforts against these parasites. In contrast, relatively few studies are being carried out in this direction for the intestinal protozoa. To contribute to a better comprehension of the epide... | ['Animals', 'Child', "Cote d'Ivoire", 'Entamoeba histolytica', 'Entamoebiasis', 'Female', 'Giardia lamblia', 'Giardiasis', 'Humans', 'Male', 'Prevalence'] | 20,087,416 | [['B01.050'], ['M01.060.406'], ['Z01.058.290.190.272'], ['B01.046.500.100.700.335.330'], ['C01.610.752.049.407'], ['B01.237.385.400'], ['C01.610.432.481', 'C01.610.752.400', 'C06.405.469.452.481'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.5... | ['Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Associations of High Intensities on Magnetization-Prepared Rapid Acquisition with Gradient Echo with Aortic Complicated Lesions in Ischemic Stroke Patients. | BACKGROUND: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-int... | ['Aged', 'Aged, 80 and over', 'Aorta, Thoracic', 'Aortic Diseases', 'Brain Ischemia', 'Databases, Factual', 'Echocardiography, Transesophageal', 'Female', 'Humans', 'Intracranial Embolism', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Plaque, Atherosclerotic', 'Predictive Value of Tests', 'Registries', 'Re... | 30,763,926 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114.056.372'], ['C14.907.109'], ['C10.228.140.300.150', 'C14.907.253.092'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Variants of serum cholinesterase (EC 3.1.1.8) in mentally retarded children]. | Using screening, electrophoretic and spectrophotometric examinations, the authors studied the polymorphism of serum cholinesterase (CE) (CP 3.1.1.8) in children with undifferentiated oligophrenia. The rates of the identified phenotypes were as follows: CHE1U--0.769; CHE1UD--0.039; CHE1UF--0.192; CHE2(5-)-1.000. The inc... | ['Adolescent', 'Alleles', 'Child', 'Cholinesterases', 'Female', 'Gene Frequency', 'Genotype', 'Humans', 'Intellectual Disability', 'Isoenzymes', 'Male'] | 3,705,846 | [['M01.060.057'], ['G05.360.340.024.340.030'], ['M01.060.406'], ['D08.811.277.352.100.170'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['D08.811.348', 'D12.776.800.300']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
New aspect of plant-rhizobia interaction: alkaloid biosynthesis in Crotalaria depends on nodulation. | Infection of legume hosts by rhizobial bacteria results in the formation of a specialized organ, the nodule, in which atmospheric nitrogen is reduced to ammonia. Nodulation requires the reprogramming of the plant cell, allowing the microsymbiont to enter the plant tissue in a highly controlled manner. We have found tha... | ['Alkyl and Aryl Transferases', 'Crotalaria', 'DNA, Complementary', 'Nitrogen', 'Plant Root Nodulation', 'Plant Roots', 'Polymerase Chain Reaction', 'Pyrrolizidine Alkaloids', 'Recombinant Proteins', 'Rhizobium', 'Symbiosis'] | 25,775,562 | [['D08.811.913.225'], ['B01.650.940.800.575.912.250.401.175'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D01.268.604', 'D01.362.625'], ['G15.682'], ['A18.400'], ['E05.393.620.500'], ['D03.132.716', 'D03.633.100.772'], ['D12.776.828'], ['B03.440.400.425.700.800', 'B03.585.900', 'B0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. | Mutations of p53 are remarkably rare in acute promyelocytic leukemias (APLs). Here, we demonstrate that the APL-associated fusion proteins PML-RAR and PLZF-RAR directly inhibit p53, allowing leukemic blasts to evade p53-dependent cancer surveillance pathways. PML-RAR causes deacetylation and degradation of p53, resulti... | ['Acetylation', 'Alleles', 'Animals', 'Cell Line', 'DNA-Binding Proteins', 'Histone Deacetylases', 'Kruppel-Like Transcription Factors', 'Mice', 'Neoplasm Proteins', 'Nuclear Proteins', 'Promyelocytic Leukemia Protein', 'Promyelocytic Leukemia Zinc Finger Protein', 'Proteasome Endopeptidase Complex', 'Proto-Oncogene Pr... | 14,976,551 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G05.360.340.024.340.030'], ['B01.050'], ['A11.251.210'], ['D12.776.260'], ['D08.811.277.087.520'], ['D12.776.260.522', 'D12.776.930.375'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.624'], ['D12.776.660'], ['D12.776.624.776.654', 'D12.776.660.745', '... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ammonium uptake by phytoplankton regulates nitrification in the sunlit ocean. | Nitrification, the microbial oxidation of ammonium to nitrate, is a central part of the nitrogen cycle. In the ocean's surface layer, the process alters the distribution of inorganic nitrogen species available to phytoplankton and produces nitrous oxide. A widely held idea among oceanographers is that nitrification is ... | ['Ammonium Compounds', 'Archaea', 'Nitrification', 'Nitrogen Cycle', 'Oceans and Seas', 'Phytoplankton', 'Sunlight'] | 25,251,022 | [['D01.625.062'], ['B02'], ['G02.111.587.500', 'G02.607.560.500', 'G16.500.768.500'], ['G02.111.587', 'G02.607.560', 'G16.500.768'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ['B05.080.500.600'], ['G01.358.500.505.650.836', 'G01.750.250.650.836', 'G01.750.770.578.836', 'G16.500.275.063.725.525', 'G16.500.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Endoscopic findings in Yersinia enterocolitica enterocolitis. | The endoscopic findings in the colon and terminal ileum in eight cases of Yersinia enterocolitica enterocolitis infection were studied. The diagnosis was based on the isolation of Y. enterocolitica in the feces and/or elevated serum antibody titers to the organism. Total colonoscopy was performed between 7 and 38 days ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Colon', 'Colonoscopy', 'Enterocolitis', 'Female', 'Humans', 'Ileocecal Valve', 'Ileum', 'Male', 'Yersinia Infections', 'Yersinia enterocolitica'] | 2,279,647 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C06.405.205.596', 'C06.405.469.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinic-based Debridement of Chronic Ulcers Has Minimal Impact on Bacteria. | Outpatient-based sharp debridement is considered an important element for the care of a chronic ulcer.OBJECTIVE: The aim of this study is to evaluate the change in bacterial amounts with sharp debridement in a clinical setting.MATERIALS AND METHODS: Bacterial autofluorescence, quantitative cultures, semiquantitative cu... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chronic Disease', 'Debridement', 'Female', 'Humans', 'Male', 'Middle Aged', 'Treatment Outcome', 'Ulcer', 'Wound Healing', 'Wound Infection'] | 29,521,643 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['E04.176'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['C23.550.891'], ['G16.762.891'], ['C01.947']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Anatomy of papilla and intra-renal reflux: microradiographic and histologic investigations (author's transl)]. | After a group of autoptic kidneys, taken from new-born babies, had been injected via the ureter with micronised barium at various pressures, they were examined micro-radiographically and histologically in order to observe the appearance of intra-renal reflux and the anatomical structures involved. The radiological patt... | ['Histological Techniques', 'Humans', 'Kidney', 'Kidney Diseases', 'Microradiography', 'Urinary Tract Infections', 'Vesico-Ureteral Reflux'] | 398,541 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of media changes on the rate of cellulose solubilisation by rumen and digester derived microbial communities. | The aim of this study was to investigate the effect of rumen fluid and leachate-based media on the ability of rumen and anaerobic digester derived microorganisms to degrade cellulose. The results demonstrated that rumen microorganisms are not capable of solubilising cellulose, or generating biomass, at an optimal rate ... | ['Animals', 'Bioreactors', 'Cellulose', 'Culture Media', 'Refuse Disposal', 'Rumen', 'Solubility'] | 17,161,596 | [['B01.050'], ['E07.115', 'J01.897.120.115'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['D27.720.470.305', 'E07.206'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['A13.869.804'], ['G02.805']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand. | The major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of gammadelta T cells independent of beta2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain or... | ['Crystallography, X-Ray', 'Histocompatibility Antigens Class I', 'Humans', 'Molecular Sequence Data', 'Protein Conformation', 'Protein Structure, Tertiary', 'beta 2-Microglobulin'] | 10,367,903 | [['E05.196.309.742.225'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G02.111.570.820.709'], ['G02.111.570.820.709.610'], ['D12.776.124.790.223.100', 'D12.776.377.715.182.100', 'D12.776.395.550.489.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Severity of somatization and its relationship to psychiatric disorders and personality. | Medical patients' (75 with chronic fatigue complaints, 61 with dizziness, and 88 with disabling tinnitus; N = 224) current and past psychiatric diagnoses and personality characteristics were assessed to determine if they could independently explain the number of medically unexplained physical symptoms that the patients... | ['Adult', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Personality', 'Personality Assessment', 'Psychiatric Status Rating Scales', 'Severity of Illness Index', 'Somatoform Disorders', 'Surveys and Questionnaires'] | 7,809,357 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['F01.752'], ['F04.513'], ['F04.711.513.653'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['F03.875'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Taking account of quality. Discussion. | Another report from the Institute of Medicine in March 2001 has joined a large body of literature documenting serious quality and safety problems. Eight health care leaders discuss ways in which organizations can reduce medical errors and improve patient outcomes. | ['Attitude of Health Personnel', 'Chief Executive Officers, Hospital', 'Humans', 'Leadership', 'Medical Errors', 'Physicians', 'Power, Psychological', 'Quality Assurance, Health Care', 'Social Responsibility', 'United States'] | 11,464,634 | [['F01.100.050', 'N05.300.100'], ['M01.526.070.490.490.100', 'M01.526.485.430.490.100', 'M01.526.485.740.380.100', 'N02.360.430.490.100', 'N02.360.740.380.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['N02.421.450'], ['M01.526.485.810', 'N02.360.810'], ['F01.658.780'], ['N04.761.700', 'N05.7... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Improving survival of malignant hypertension patients over 40 years. | BACKGROUND: To examine changing demography and survival of patients with malignant phase hypertension (MHT) over 40 years.METHODS: Patients from our MHT registry whose survival status on 31 December 2006 was known were included, with analyses conducted based on decade of MHT diagnosis.RESULTS: Four-hundred and forty-si... | ['Adult', 'African Continental Ancestry Group', 'Asian Continental Ancestry Group', 'Demography', 'European Continental Ancestry Group', 'Female', 'Forecasting', 'Humans', 'Hypertension, Malignant', 'Male', 'Middle Aged', 'Regression Analysis'] | 19,696,746 | [['M01.060.116'], ['M01.686.508.100'], ['M01.686.508.200'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['M01.686.508.400'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489.330'], ['M01.060.116.630'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Anesthesia for foreign bodies in the tracheo-bronchial tree in children. | The authors present the anesthetic and ventilation techniques, used in 106 children, who were suspected of foreign body aspiration in the respiratory tract. In 62 children a foreign body was found. The youngest child was 8 months old and the oldest 13 years, with an age distribution peak in the 1 to 2 years age group. ... | ['Adolescent', 'Anesthesia, Inhalation', 'Bronchi', 'Bronchoscopy', 'Child', 'Child, Preschool', 'Female', 'Foreign Bodies', 'Humans', 'Infant', 'Male', 'Positive-Pressure Respiration', 'Retrospective Studies', 'Trachea'] | 3,904,303 | [['M01.060.057'], ['E03.155.197.197'], ['A04.411.125'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['M01.060.406'], ['M01.060.406.448'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.041.625.790', 'E02.880.820.790'], ['E05.318.372.500.500.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Seasonal climatic variations influence the efficacy of predatory mites used for control of western flower thrips in greenhouse ornamental crops. | The influence of seasonal greenhouse climate on the efficacy of predatory mites for thrips control was determined for potted chrysanthemum. Trials in controlled environment chambers, small-scale greenhouses and commercial greenhouses were conducted to determine which biological control agent-that is, Amblyseius swirski... | ['Agriculture', 'Animals', 'Climate', 'Flowers', 'Mites', 'Pest Control, Biological', 'Predatory Behavior', 'Seasons', 'Species Specificity', 'Thysanoptera'] | 25,408,478 | [['J01.040'], ['B01.050'], ['G16.500.275.071', 'N06.230.300.100.250'], ['A18.024.249.500'], ['B01.050.500.131.166.132.419'], ['N06.850.780.200.650.650'], ['F01.145.113.111.600', 'F01.145.113.252.520'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['G16.824'], ['B01.050.500.131.617.800']] | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Lack of association between scleroderma and types I and III procollagen gene restriction fragment length polymorphisms. | Restriction fragment length polymorphisms (RFLPs) in types I and III procollagen genes were studied in 62 scleroderma patients and 138 healthy controls. Allelic frequencies were determined for each RFLP, and comparisons were made between the 2 populations, stratifying them by race when appropriate. No statistically sig... | ['African Continental Ancestry Group', 'Alleles', 'European Continental Ancestry Group', 'Genes', 'Humans', 'Polymorphism, Restriction Fragment Length', 'Procollagen', 'Scleroderma, Systemic'] | 2,574,578 | [['M01.686.508.100'], ['G05.360.340.024.340.030'], ['M01.686.508.400'], ['G05.360.340.024.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.595'], ['D12.776.811.690', 'D12.776.860.300.250.600'], ['C17.300.799', 'C17.800.784']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Compensation of gradient related effects when using capillary liquid chromatography and inductively coupled plasma mass spectrometry for the absolute quantification of phosphorylated peptides. | The application of reversed phase liquid chromatography (RP-LC) hyphenated to inductively coupled plasma mass spectrometry (ICP-MS) for the accurate quantification of bio-molecules via covalently bound hetero atoms such as phosphorus is restricted, due to the known effects of increasing amounts of organic solvents on t... | ['Chromatography, High Pressure Liquid', 'Mass Spectrometry', 'Phosphopeptides'] | 19,709,666 | [['E05.196.181.400.300'], ['E05.196.566'], ['D12.644.717']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chest physicians' knowledge of appropriate thromboprophylaxis: insights from the PROMOTE study. | Venous thromboembolism (VTE) is a major cause of in-hospital mortality. Several international guidelines provide thromboprophylaxis recommendations; however, guidelines adherence is missing worldwide. We evaluated the chest physicians' knowledge regarding VTE prophylaxis, using a systematically developed questionnaire.... | ['Adult', 'Aged', 'Aged, 80 and over', 'Algorithms', 'Anticoagulants', 'Disease Management', 'Female', 'Guideline Adherence', 'Humans', 'Immobilization', 'Internal Medicine', 'Male', 'Middle Aged', 'Neoplasms', 'Practice Guidelines as Topic', 'Risk Factors', 'Surveys and Questionnaires', 'Thoracoscopy', 'Venous Thrombo... | 21,986,466 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['D27.505.954.502.119'], ['N04.590.607'], ['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.472'], ['H02.403.429'], ['M01.060.116.630'], ['C04'], ['N04.761.700.350.650', 'N05.700.350.650'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Methodological considerations to determine the effect of exercise on brain-derived neurotrophic factor levels. | OBJECTIVES: Physical exercise up-regulates brain-derived neurotrophic factor (BDNF) in the brain and blood. However, there is yet no consensus about the adequate blood processing conditions to standardize its assessment. We aimed to find a reliable blood sample processing method to determine changes in BDNF due to exer... | ['Adult', 'Blood Specimen Collection', 'Brain-Derived Neurotrophic Factor', 'Energy Metabolism', 'Exercise', 'Humans', 'Male', 'Serum', 'Surveys and Questionnaires'] | 25,464,018 | [['M01.060.116'], ['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['G03.295'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.207.152.846', 'A15.145.846'], ['E05.318.308.980',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Production of transgenic mice from DNA-injected embryos cryopreserved by vitrification in microdrops. | Transgenic mice were produced from DNA-injected embryos stored for 2 to 30 days in liquid nitrogen. Of the 500 zygotes collected from (C57BL/6 x CBA)F1 mice, 363 (73%) survived DNA injection into pronuclei and 246 (82%) morphologically normal 4- and 8-cell embryos were flushed from temporary recipients 48 h later. Of t... | ['Animals', 'Cryopreservation', 'DNA', 'Embryo Transfer', 'Embryo, Mammalian', 'Erythropoietin', 'Gene Expression', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Mice, Transgenic', 'Microinjections', 'Survival Rate', 'Transfection'] | 1,597,250 | [['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D13.444.308'], ['E02.875.800.500', 'E05.820.800.500'], ['A16.254'], ['D12.644.276.374.410.240.150', 'D12.776.395.240.150', 'D12.776.467.374.410.240.150', 'D... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Aging--a potential pitfall of continent urinary diversions. | We report three cases of patients with Kock-pouches, who developed late complications related to old age. Based on these findings, the fate of aging patients with continent urinary diversions is discussed. | ['Aged', 'Aging', 'Female', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Self Care', 'Urinary Bladder Neoplasms', 'Urinary Bladder, Neurogenic', 'Urinary Catheterization', 'Urinary Reservoirs, Continent'] | 8,908,657 | [['M01.060.116.100'], ['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E02.900', 'I03.050.563', 'N02.421.784.680'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', 'C13.351.968.829.707... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Long-term outcome of bifurcation stenting with drug-eluting stents. | There are little long-term clinical data regarding the safety and efficacy of using 2 drug-eluting stents (DESs) to treat coronary bifurcation lesions. We obtained clinical follow-up for 124 consecutive patients who underwent bifurcation stenting with 2 DESs. Major adverse cardiac events (MACEs) were defined as cardiac... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Stenosis', 'Drug-Eluting Stents', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Design', 'Retrospective Studies', 'Treatment Outcome'] | 20,529,974 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predominant phage types of coagulase positive staphylococci in hospital infections. | 360 strains of Staphylococcus aureus isolated from various clinical specimens were subjected to bacteriophage typing. 247(68.6%) strains were typable. Among the typable strains 75(20.83%) belonged to phage group I, 45(12.5%) belonged to phage group III, 6(1.67%) belonged to phage group II and 14(3.89%) strains belonged... | ['Bacteriophage Typing', 'Coagulase', 'Cross Infection', 'Humans', 'Retrospective Studies', 'Staphylococcal Infections', 'Staphylococcus Phages', 'Staphylococcus aureus'] | 10,798,018 | [['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['D08.811.277.656.300.174', 'D12.776.097.181'], ['C01.248', 'C23.550.291.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Darwin and the neural bases of emotion and affective style. | This article presents an overview of ways to think about the brain and emotion and consider the role of evolution and expression in shaping the neural circuitry of affective processing. Issues pertaining to whether there are separate unique neural modules hard-wired for emotion processing or whether affective processin... | ['Affect', 'Amygdala', 'Biological Evolution', 'Corticotropin-Releasing Hormone', 'Humans', 'Neurons', 'Prefrontal Cortex', 'Receptors, Serotonin'] | 14,766,646 | [['F01.470.047'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['G05.045', 'G16.075'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.675', 'A11.671'], ['A08.186.211.200.885.287.500.2... | ['Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Diagnostic Validity of Citric Acid-Free, High Dose (13)C-Urea Breath Test After Helicobacter pylori Eradication in Korea. | BACKGROUND: The (13)C-urea breath test ((13)C-UBT) is a noninvasive method for diagnosing Helicobacter pylori (H. pylori) infection. The aims of this study were to evaluate the diagnostic validity of the (13)C-UBT cutoff value and to identify influencing clinical factors responsible for aberrant results.METHODS: (13)C-... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biopsy', 'Breath Tests', 'Carbon Isotopes', 'Citric Acid', 'Endoscopy', 'False Positive Reactions', 'Female', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Middle Aged', 'Republic of Korea', 'Retrospective Studies', 'Sensitivity and Specificity', 'Urea', 'Y... | 25,640,474 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.100'], ['D01.268.150.075', 'D01.496.123'], ['D02.241.081.901.434.249'], ['E01.370.388.250', 'E04.502.25... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunomodulatory effects of NIM-76, a volatile fraction from Neem oil. | The immunomodulatory properties of NIM-76 have been described in this paper. Pre-treatment of rats with a single i.p. injection of NIM-76 resulted in an increase in polymorphonuclear (PMN) leukocytes with a concomitant decrease in lymphocyte counts. The immunomodulatory activity of NIM-76 was found to be concentration-... | ['Adjuvants, Immunologic', 'Animals', 'Antibody Formation', 'Dose-Response Relationship, Drug', 'Erythrocytes', 'Glycerides', 'Injections, Intraperitoneal', 'Lymphocyte Activation', 'Lymphocyte Count', 'Macrophage Activation', 'Male', 'Neutrophils', 'Oils, Volatile', 'Phagocytosis', 'Plant Oils', 'Rats', 'Rats, Sprague... | 9,032,626 | [['D27.505.696.477.067'], ['B01.050'], ['G12.450.050.370.250'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D10.351'], ['E02.319.267.530.490'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['E01.370.225.500.195.107.595.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Patients' Illness Perception as a Tool to Improve Individual Disease Management in Primary Cutaneous Lymphomas. | The Revised Illness Perception Questionnaire (IPQ-R) has been shown to assess illness perception reproducibly in primary cutaneous T-cell lymphomas (CTCL). Illness perception reflects patients' individual concepts of understanding and interpretation of the disease, influencing illness behaviour and health-related quali... | ['Adult', 'Aged', 'Cost of Illness', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Illness Behavior', 'Lymphoma, B-Cell', 'Lymphoma, T-Cell, Cutaneous', 'Male', 'Middle Aged', 'Patients', 'Perception', 'Predictive Value of Tests', 'Prognosis', 'Skin Neoplasms', 'Surveys and Qu... | 29,048,099 | [['M01.060.116'], ['M01.060.116.100'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.499'], ['C04... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cohort differences in exercise adherence among primary care patients referred for mental health versus physical health conditions. | Aim To compare the characteristics of mental health and physical health participants attending an exercise referral scheme (ERS) and investigate associations with their adherence to exercise.BACKGROUND: While people referred to an ERS with a mental health diagnosis have similar initial rates of uptake as physical healt... | ['Adult', 'Aged', 'Aged, 80 and over', 'Exercise Therapy', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Patient Compliance', 'Primary Health Care', 'Retrospective Studies'] | 28,653,595 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['N04.590.233.727'], ['E05.318.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Detection of human endogenous retrovirus type K-specific transcripts in testicular parenchyma and testicular germ cell tumors of adolescents and adults: clinical and biological implications. | Testicular germ cell tumors (TGCTs) of adolescents and adults have been shown to contain proteins of the human endogenous retrovirus type K family. In a recent study, expression of these retroviral sequences was confirmed using in situ hybridization, which also showed expression in carcinoma in situ, the precursor of a... | ['Adolescent', 'Adult', 'Bacterial Proteins', 'Base Sequence', 'Carcinoma in Situ', 'DNA Primers', 'DNA, Viral', 'Endogenous Retroviruses', 'Genes, env', 'Genes, gag', 'Germinoma', 'Humans', 'Male', 'Metalloendopeptidases', 'Molecular Sequence Data', 'Reverse Transcriptase Polymerase Chain Reaction', 'Testicular Neopla... | 9,777,959 | [['M01.060.057'], ['M01.060.116'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.557.470.200.240'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.568'], ['B04.613.807.250', 'B04.820.650.250', 'G02.111.570.080.708.330.800.175', 'G05.360.080.708.330.800.175'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Involvement of phospholipase D in caerulein-induced phosphatidylcholine hydrolysis in rat pancreatic acini. | Phosphatidylcholine (PC) metabolism stimulated by caerulein (Cae), a cholecystokinin analogue, was investigated in rat pancreatic acini prelabeled with [3H]choline or [3H]-myristic acid. Both labels were incorporated mostly into PC. An inhibition of choline incorporation into PC was first observed in response to Cae (1... | ['Animals', 'Ceruletide', 'Choline', 'Enzyme Activation', 'Glycerophospholipids', 'Hydrolysis', 'Pancreas', 'Phosphatidic Acids', 'Phosphatidylcholines', 'Phospholipase D', 'Phospholipids', 'Rats'] | 8,238,356 | [['B01.050'], ['D12.644.456.241'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['G02.111.263', 'G03.328'], ['D10.570.755.375.760.400'], ['G02.380'], ['A03.734'], ['D10.570.755.375.760'], ['D10.570.755.375.760.400.800'], ['D08.811.277.352.640.700.710'], ['D10.570.755'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel anatomical ceramic root canal simulator for endodontic training. | INTRODUCTION: Endodontic therapy is often complicated and technically demanding. The aim of this study was to develop a reproducible biomimetic root canal model for pre-clinical and postgraduate endodontic training.MATERIAL AND METHODS: A specific ceramic shaping technique (3D printing and slip casting of a root canal ... | ['Ceramics', 'Dental Pulp Cavity', 'Endodontics', 'Models, Anatomic', 'Printing, Three-Dimensional', 'Simulation Training'] | 27,146,633 | [['J01.637.153'], ['A14.549.167.900.265'], ['E06.397', 'H02.163.876.213'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['J01.897.564', 'L01.224.108.150.500', 'L01.296.110.150.500'], ['I02.903.847']] | ['Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
Determination of deoxynivalenol in wheat, barley, and malt by column cleanup and gas chromatography with electron capture detection. | A rapid and reliable method to determine deoxynivalenol (DON) in wheat, barley, and malt is described. Samples are extracted with acetonitrile-water (84 + 16). Extracts are eluted through a C18-alumina (1 + 3) column, evaporated to dryness, and derivatized with trimethylsilylimidazole-trimethylchlorosilane (100 + 1). D... | ['Chromatography, Gas', 'Edible Grain', 'Food Analysis', 'Food Contamination', 'Hordeum', 'Trichothecenes', 'Triticum'] | 8,920,135 | [['E05.196.181.349'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02.500.775.500'], ['E05.362', 'J01.576.423.850.100'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['B01.650.940.800.575.912.250.822.481'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Improved matrix inversion in image plane parallel MRI. | A new 3D parallel magnetic resonance imaging (MRI) method named Generalized Unaliasing Incorporating Support constraint and sensitivity Encoding (GUISE) is presented. GUISE allows direct image recovery from arbitrary Cartesian k-space trajectories. However, periodic k-space sampling patterns are considered for reconstr... | ['Algorithms', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 19,269,768 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Quantitative outcome of registration methods for correcting cardiac drift in cardiac PET/CT imaging. | Myocardial perfusion studies suffer from artifacts caused by misalignment of the transmission and emission data due to the influences of voluntary and involuntary patient motion. Regardless of 68Ge or respiratory-averaged CT based attenuation correction and good patient cooperation, approximately 21% of perfusion studi... | ['Algorithms', 'Artifacts', 'Fluorodeoxyglucose F18', 'Heart', 'Humans', 'Image Interpretation, Computer-Assisted', 'Imaging, Three-Dimensional', 'Movement', 'Patient Positioning', 'Phantoms, Imaging', 'Positron Emission Tomography Computed Tomography', 'Radionuclide Imaging', 'Respiratory Mechanics'] | 27,074,462 | [['G17.035', 'L01.224.050'], ['E05.047'], ['D09.254.229.500'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.400', 'L01.224.308.410'], ['G07.568', 'G11.427.410'], ['E02.760.670', 'N02.421.585.700'], ['E07.671'], ['E01.370.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. | OBJECTIVE: In two preliminary studies, pindolol produced robust results in hastening clinical response to antidepressant drugs in depressed patients. Validity of those pilot studies was limited by use of an open-label, unblinded study design, and so the authors conducted a double-blind, placebo-controlled trial to asse... | ['Adolescent', 'Adult', 'Aged', 'Ambulatory Care', 'Depressive Disorder', 'Double-Blind Method', 'Drug Interactions', 'Drug Therapy, Combination', 'Female', 'Fluoxetine', 'Humans', 'Male', 'Middle Aged', 'Pindolol', 'Placebos', 'Treatment Outcome'] | 8,988,956 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['F03.600.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G07.690.773.968'], ['E02.319.310'], ['D02.092.831.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Changes in contents of Zn, Cu, Fe, Ca, Mg in serum, urine and blister fluid after burn injury]. | 106 burned patients were divided into two groups: group L consisted of 57 patients with burns larger than 30% TBSA, and group S consisted of 49 patients with burns smaller than 30% TBSA. The contents of Zn, Cu, Fe, Ca, Mg in serum, urine and blister fluid were determined on 1, 2, 3, 7, 14, 21, 28 days after burn injury... | ['Adolescent', 'Adult', 'Aged', 'Blister', 'Burns', 'Calcium', 'Copper', 'Exudates and Transudates', 'Female', 'Humans', 'Male', 'Middle Aged', 'Zinc'] | 10,451,999 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C17.800.865.187', 'C23.300.122'], ['C26.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['A12.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D01.268.556.940'... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Palatability and intake relationships in free-living humans. characterization and independence of influence in North Americans. | In order to investigate palatability influences on the ad lib eating behavior of free-living humans, 564 participants were paid to maintain food intake diaries for 7 days. They recorded their intake along with a global rating of the palatability of the entire meal on a seven-point scale. It was found that most meals th... | ['Adolescent', 'Adult', 'Aged', 'Alcohol Drinking', 'Diet', 'Dietary Carbohydrates', 'Dietary Fats', 'Dietary Proteins', 'Eating', 'Feeding Behavior', 'Female', 'Food Preferences', 'Humans', 'Hunger', 'Male', 'Middle Aged', 'North America', 'Regression Analysis'] | 11,006,433 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['G07.203.650.240'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.283', 'G10.261.330'], ['F01.145.113.547', 'F01.145.407', 'G... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Diminished reactive hyperemia in the skin of critically ill patients. | Reactive hyperemia (RH) in the forearm skin after an arterial occlusion of 5 min was investigated in 29 ICU patients and 17 age-matched healthy control subjects using a transcutaneous PO2/PCO2 electrode heated to 37 degrees C. There was no difference in preocclusive baseline PtCO2 between patients (8 +/- 5 torr) and co... | ['Adolescent', 'Adult', 'Aged', 'Critical Care', 'Female', 'Humans', 'Hyperemia', 'Male', 'Microcirculation', 'Middle Aged', 'Oxygen Consumption', 'Severity of Illness Index', 'Skin'] | 2,379,393 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.760.190', 'N02.421.585.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.474'], ['G09.330.100.645'], ['M01.060.116.630'], ['G03.680'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proteomics of arsenic stress in the gram-positive organism Exiguobacterium sp. PS NCIM 5463. | The general responses of microorganisms to environmental onslaughts are modulated by altering the gene expression pattern to reduce damage in the cell and produce compensating stress responses. The present study attempts to unravel the response of the Gram-positive Exiguobacterium sp. PS NCIM 5463 in the presence of [A... | ['Arsenates', 'Arsenic', 'Bacillaceae', 'Bacterial Proteins', 'Electrophoresis, Gel, Two-Dimensional', 'Mass Spectrometry', 'Molecular Sequence Data', 'Proteomics'] | 24,931,308 | [['D01.075.025', 'D01.248.497.158.050'], ['D01.268.513.249'], ['B03.300.390.400.158', 'B03.353.500.100', 'B03.510.100.100', 'B03.510.415.400.158', 'B03.510.460.410.158'], ['D12.776.097'], ['E05.196.401.250', 'E05.301.300.230'], ['E05.196.566'], ['L01.453.245.667'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.15... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of atrial contraction frequency on atrial natriuretic peptide secretion. | Paroxysms of atrial tachycardia are oftentimes associated with polyuria. The plasma levels of the potent diuretic hormone, atrial natriuretic peptide (ANP), are elevated during episodes of atrial tachycardia, suggesting that ANP may play a role in mediating the diuresis. The mechanism of enhanced ANP secretion associat... | ['Animals', 'Atrial Natriuretic Factor', 'Atropine', 'Female', 'Heart Atria', 'Myocardial Contraction', 'Perfusion', 'Phentolamine', 'Propranolol', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 2,946,242 | [['B01.050'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['A07.541.358'], ['G09.330.580', 'G11.427.494.570'], ['E05.680'], ['D03.383.129.308.754'], ['D02.033.100.624.698.711', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Assessment of Atrial Electromechanical Delay in Patients With Acromegaly. | BACKGROUND: We aimed to evaluate whether atrial electromechanical delay (AEMD) measured by tissue Doppler imaging (TDI), which is an indicator for structural and electrical remodelling of the atria, is prolonged in patients with active or inactive acromegaly, or both, compared with a control group.METHODS: A total of 3... | ['Acromegaly', 'Atrial Function', 'Atrial Premature Complexes', 'Echocardiography, Doppler', 'Electrocardiography', 'Female', 'Heart Atria', 'Humans', 'Male', 'Middle Aged'] | 26,117,621 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['G09.330.040'], ['C14.280.067.325.250', 'C14.280.123.375.250', 'C23.550.073.325.050'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Metabolic reorganization in winter: Regulation of pyruvate dehydrogenase (PDH) during long-term freezing and anoxia. | Wood frogs, Rana sylvatica, can undergo prolonged periods of whole body freezing during winter, locking as much as 65-70% of total body water into extracellular ice and imposing both anoxia and dehydration on their cells. Metabolic rate depression (MRD) is an adaptation used by R. sylvatica to survive these environment... | ['Acclimatization', 'Animals', 'Basal Metabolism', 'Cryopreservation', 'Dehydration', 'Freezing', 'Gene Expression Regulation', 'Hypoxia', 'Liver', 'Muscle, Skeletal', 'Oxidation-Reduction', 'Phosphorylation', 'Pyruvate Dehydrogenase Acetyl-Transferring Kinase', 'Pyruvate Dehydrogenase Complex', 'Ranidae', 'Stress, Phy... | 30,639,451 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['G03.295.154'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['C18.452.950.179', 'C23.550.274'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['G05.308'], [... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols. | An enantioselective redox-relay oxidative Heck arylation of 1,1-disubstituted alkenes to construct â-stereocenters was developed using a new pyridyl-oxazoline ligand. Various 1,2-diaryl carbonyl compounds were readily obtained in moderate yield and good to excellent enantioselectivity. Additionally, analysis of the rea... | ['Alcohols', 'Alkenes', 'Catalysis', 'Oxidation-Reduction', 'Palladium', 'Stereoisomerism'] | 27,571,167 | [['D02.033'], ['D02.455.326.271'], ['G02.130'], ['G02.700', 'G03.295.531'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adverse effect of cyclophosphamide at moderate dose in combination with standard drugs on intraperitoneally implanted Lewis lung carcinoma in mice. | Adverse (tumor-enhancing) effects of cyclophosphamide at moderate dose (50 mg/kg) given therapeutically were confirmed on the intraperitoneally implanted Lewis lung carcinoma (LLC) in allogeneic DBA/2 and BALB/c mice. It was recently demonstrated that antitumor effects of five standard drugs (actinomycin D, adriamycin,... | ['Animals', 'Antineoplastic Agents', 'Cyclophosphamide', 'Drug Interactions', 'Drug Therapy, Combination', 'Lung Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Neoplasm Transplantation'] | 3,996,089 | [['B01.050'], ['D27.505.954.248'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['G07.690.773.968'], ['E02.319.310'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum | Co-infection of malaria and tuberculosis, although not thoroughly investigated, has been noted. With the increasing prevalence of tuberculosis in the African region, wherein malaria is endemic, it is intuitive to suggest that the probability of co-infection with these diseases is likely to increase. To avoid the issue ... | ['Animals', 'Anti-Infective Agents', 'Candy', 'Drug Interactions', 'HeLa Cells', 'Humans', 'Inhibitory Concentration 50', 'Malaria, Falciparum', 'Molecular Structure', 'Mycobacterium tuberculosis', 'Plasmodium falciparum', 'Quinolones', 'Small Molecule Libraries', 'Thiosemicarbazones', 'Tuberculosis'] | 31,060,249 | [['B01.050'], ['D27.505.954.122'], ['G07.203.300.140', 'J02.500.140'], ['G07.690.773.968'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.350', 'G07.690.936.563'], ['C01.610.752.530.650', 'C01.920.875.650'], ['G02.111.570', 'G02.466'], ['B03.51... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A novel, homozygous nonsense variant of the CDHR1 gene in a Chinese family causes autosomal recessive retinal dystrophy by NGS-based genetic diagnosis. | Retinal dystrophy is an inherited, heterogeneous, chronic and progressive disorder of visual functions. The mutations of patients with autosomal recessive retinal retinopathy cone-and-rod dysfunction and macular dystrophy have not been well described in the Chinese population. In this study, a three-generation Chinese ... | ['Adult', 'Animals', 'Cadherins', 'China', 'Codon, Nonsense', 'DNA Mutational Analysis', 'Female', 'High-Throughput Nucleotide Sequencing', 'Homozygote', 'Humans', 'Male', 'Mice', 'Middle Aged', 'Nerve Tissue Proteins', 'Pedigree', 'Phenotype', 'Retina', 'Retinal Dystrophies'] | 30,160,356 | [['M01.060.116'], ['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['Z01.252.474.164'], ['D13.444.735.544.355.250.235', 'G05.360.335.355.250.235', 'G05.365.590.195'], ['E05.393.760.700.300'], ['E05.393.760.319'], ['G05.380.554'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Design and synthesis of novel chiral dendritic species derived from bile acids. | Bile acids have been used for the first time as the building block for the construction of dendritic units. Orthogonally functionalized 7-deoxycholic and cholic acid derivatives were synthesized. The construction of a bile acid heptamer, a nonamer, and a decamer using the convergent strategy are described in detail. Ch... | ['Bile Acids and Salts', 'Cholic Acid', 'Chromatography, High Pressure Liquid', 'Deoxycholic Acid', 'Magnetic Resonance Spectroscopy', 'Molecular Weight', 'Polymers', 'Spectrophotometry, Ultraviolet'] | 11,325,268 | [['D04.210.500.105'], ['D04.210.500.105.225.130', 'D04.210.500.221.430.130'], ['E05.196.181.400.300'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['E05.196.867.519'], ['G02.494'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells. | Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal cell interaction and CXCR4 and B-cell receptor activation. Because of the importance of phosphatidylinositol-3-kinase signaling in chronic lymphocytic leukemia, we ... | ['Aged', 'Aged, 80 and over', 'Aminopyridines', 'Apoptosis Regulatory Proteins', 'Bcl-2-Like Protein 11', 'Cell Movement', 'Coculture Techniques', 'Drug Resistance, Neoplasm', 'Forkhead Box Protein O3', 'Forkhead Transcription Factors', 'Humans', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Membrane Proteins', 'Middle Ag... | 23,850,807 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.092.080', 'D03.383.725.050'], ['D12.644.360.075', 'D12.776.476.075'], ['D12.644.360.075.323', 'D12.776.476.075.323', 'D12.776.543.116', 'D12.776.624.664.700.025'], ['G04.198', 'G07.568.500.180'], ['E05.481.500.374'], ['G07.690.773.984.395'], ['D12.776.260.950.249.125... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between brain electrical activity and cortical perfusion in normal subjects. | Cerebral glucose uptake and perfusion are accepted as tightly coupled measures of energy utilization in both normal and diseased brain. The coupling of brain electrical activity to perfusion has been demonstrated, however, only in the presence of chronic brain disease. Very few studies have examined the relationship be... | ['Adult', 'Algorithms', 'Brain', 'Brain Mapping', 'Cerebral Cortex', 'Cerebrovascular Circulation', 'Electroencephalography', 'Humans', 'Male', 'Psychomotor Performance', 'Reference Values', 'Tomography, Emission-Computed'] | 10,482,384 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['G09.330.100.159'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808', 'G11.427.700', 'G11.561.660... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition. | PURPOSE: There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure ... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Amyloid', 'Aniline Compounds', 'Benzothiazoles', 'Brain', 'Brain Mapping', 'Female', 'Fluorodeoxyglucose F18', 'Glucose', 'Humans', 'Lewy Body Disease', 'Male', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Thiazoles'] | 25,270,712 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D05.500.049', 'D12.776.049'], ['D02.092.146'], ['D03.383.129.708.089', 'D03.633.100.185'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D09.254.229.500'], ['D0... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression analysis of thirty one Y chromosome genes in human prostate cancer. | Rapid advances in positional cloning studies have identified most of the genes on the human Y chromosome, thereby providing resources for studying the expression of its genes in prostate cancer. Using a semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) procedure, we had examined the expression o... | ['Androgens', 'Base Sequence', 'DNA Primers', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'Prostatic Neoplasms', 'Reverse Transcriptase Polymerase Chain Reaction', 'Y Chromosome'] | 10,747,295 | [['D27.505.696.399.472.161'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E05.393.620.500.725']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition. | Variants of the pyruvate dehydrogenase subunit (E1; EC ) of the Escherichia coli pyruvate dehydrogenase multienzyme complex with Y177A and Y177F substitutions were created. Both variants displayed pyruvate dehydrogenase multienzyme complex activity at levels of 11% (Y177A E1) and 7% (Y177F E1) of the parental enzyme. T... | ['Amino Acid Sequence', 'Base Sequence', 'Circular Dichroism', 'DNA Primers', 'Enzyme Inhibitors', 'Escherichia coli', 'Kinetics', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Pyruvate Dehydrogenase Complex', 'Sequence Homology, Amino Acid', 'Spectrometry, Fluorescence', 'Thiamine', 'Thiazoles', 'Tyrosine'... | 11,583,990 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.867.151'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D27.505.519.389'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['E05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Will That Pulmonary Nodule Become Cancerous? A Risk Prediction Model for Incident Lung Cancer. | This prospective investigation derived a prediction model for identifying risk of incident lung cancer among patients with visible lung nodules identified on computed tomography (CT). Among 2,924 eligible patients referred for evaluation of a pulmonary nodule to the Stony Brook Lung Cancer Evaluation Center between Jan... | ['Aged', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Models, Statistical', 'New York', 'Prognosis', 'ROC Curve', 'Smoking', 'Solitary Pulmonary Nodule'] | 31,248,853 | [['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04.588.894.797.520', 'C08.381.540', 'C08.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. | Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but is also implicated in physiological processes like ageing. Non-resolving inflammation and prolonged neuroinflammation are unclear processes implicated in several conditions, including ageing. In this study we studied the l... | ['Aging', 'Animals', 'Astrocytes', 'Gene Expression Regulation', 'Hippocampus', 'Inflammation', 'Interleukin-1beta', 'Lipopolysaccharides', 'Male', 'Rats', 'Rats, Wistar', 'Signal Transduction', 'Transcription Factor RelA'] | 25,170,959 | [['G07.345.124'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['G05.308'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['C23.550.470'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D12.776.467.374.465.010.600', 'D12.776.467.374.500.400.600', 'D23.529.374.465.131.600', 'D23.529.374.50... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,3',5-triiodo-l-thyronine (T3) highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae. | Some chemicals in the environment disrupt thyroid hormone (TH) systems leading to alterations in organism development, but their effect mechanisms are poorly understood. In fish, this has been limited by a lack of fundamental knowledge on thyroid gene ontogeny and tissue expression in early life stages. Here we establi... | ['Animals', 'Corticotropin-Releasing Hormone', 'Hypothalamus', 'Larva', 'Pituitary Gland', 'Thyroid Gland', 'Thyroid Hormones', 'Thyronines', 'Thyrotropin', 'Triiodothyronine', 'Water Pollutants, Chemical', 'Zebrafish', 'Zebrafish Proteins'] | 32,623,180 | [['B01.050'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['B05.500.500', 'G07.345.500.550.500.500'], ['A06.300.747', 'A06.688.357.750', 'A08.186.211.180.497.352.435.500', 'A08.186.211.200.317.357.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of melatonin and pinealectomy upon local cerebral glucose utilization in awake unrestrained rats are restricted to a few specific regions. | The effects of the infusion of melatonin (MT) and/or of pinealectomy upon glucose utilization in anatomically discrete regions of the brain of freely moving rats have been studied by the quantitative autoradiographic 2-deoxy-D-[1-14C]glucose technique. The experiments were made from 14.00 to 16.00 h, when MT is normall... | ['Animals', 'Brain', 'Cerebral Ventricles', 'Deoxyglucose', 'Glucose', 'Hypothalamus', 'Male', 'Medulla Oblongata', 'Melatonin', 'Pineal Gland', 'Rats', 'Rats, Inbred Strains'] | 2,743,157 | [['B01.050'], ['A08.186.211'], ['A08.186.211.140'], ['D09.254.229'], ['D09.947.875.359.448'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['A08.186.211.132.810.591.500'], ['D03.633.100.473.914.481', 'D06.472.506'], ['A06.300.635', 'A06.688.733', 'A08.186.211.180.200.680', 'A08.186.211.200.317.200.620', 'A08.713... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. | Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminogen activator (uPA). One hundred and sixty nine prostate tissue section... | ['Biomarkers, Tumor', 'Chemotaxis', 'Collagen', 'Disease Progression', 'Humans', 'Male', 'Mannose-Binding Lectins', 'Matrix Metalloproteinase 14', 'Membrane Glycoproteins', 'Neoplasm Proteins', 'Prognosis', 'Prostate-Specific Antigen', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'Receptors, Cell Surface', 'Receptor... | 19,112,015 | [['D23.101.140'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.503.311'], ['D08.811.277.656.300.480.525.300.500', 'D08.811.2... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterisation of stationary phases in subcritical fluid chromatography with the solvation parameter model IV. Aromatic stationary phases. | The purpose of the present work was to systematically study the chromatographic behaviour of different aromatic stationary phases in a subcritical fluid mobile phase. We attempted to assess the chemical origin of the differences in retention characteristics between the different columns. Various types of aromatic stati... | ['Benzene Derivatives', 'Chromatography, Liquid', 'Graphite', 'Silicon Dioxide'] | 16,529,759 | [['D02.455.426.559.389'], ['E05.196.181.400'], ['D01.268.150.300', 'D01.578.300'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rational design of catechol-2, 3-dioxygenase for improving the enzyme characteristics. | Catechol-2, 3-dioxygenase (C23O) from Pseudomonas sp. CGMCC2953 identified in our laboratory, which is one of the key enzymes responsible for phenanthrene biodegradation, was expected to get better characteristics tolerant to environment for its further application. With the aim of improving the enzyme properties by in... | ['Amino Acid Sequence', 'Catechol 2,3-Dioxygenase', 'Conserved Sequence', 'Disulfides', 'Enzyme Stability', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Internet', 'Kinetics', 'Models, Molecular', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Mutation', 'Protein Conformation', 'Pseudomonas', 'Temperat... | 19,688,300 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.682.690.416.305'], ['G02.111.570.580'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['E05.916.360', 'G02.111.700.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.300'], ['L01.224.230.110.500'], ['G01.374.661', 'G02.111... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. | Cajal-Retzius cells are critical in cortical lamination, but very little is known about their origin and development. The homeodomain transcription factor Dbx1 is expressed in restricted progenitor domains of the developing pallium: the ventral pallium (VP) and the septum. Using genetic tracing and ablation experiments... | ['Aging', 'Animals', 'Animals, Newborn', 'Calbindin 2', 'Cell Adhesion Molecules, Neuronal', 'Cell Division', 'Cell Movement', 'Cerebral Cortex', 'Embryo, Mammalian', 'Extracellular Matrix Proteins', 'Genetic Techniques', 'Homeodomain Proteins', 'Mice', 'Mice, Neurologic Mutants', 'Nerve Tissue Proteins', 'Neurons', 'R... | 16,041,369 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['D12.776.157.125.090.249'], ['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['A08.186.211.200.885.287.500'], ['A16.254'], ['D12.77... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Percutaneous aspiration embolectomy of the popliteal artery]. | Twenty-eight patients (17 women, 11 men, average age 67 years, range 40-85 years) with embolic occlusions of the popliteal arteries were treated by aspiration embolectomy. 6 patients were in clinical stage IIb and 22 in stage III. In 25 of the 28 patients the occlusion was treated successfully. Complications could be t... | ['Adult', 'Aged', 'Aged, 80 and over', 'Angiography, Digital Subtraction', 'Embolectomy', 'Embolism', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Popliteal Artery', 'Radiography, Interventional', 'Recurrence', 'Suction', 'Ultrasonography'] | 1,391,840 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['E04.100.814.445'], ['C14.907.355.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
On the binding of BODIPY-GTP by the photosensory protein YtvA from the common soil bacterium Bacillus subtilis. | The YtvA protein, which is one of the proteins that comprises the network carrying out the signal transfer inducing the general stress response in Bacillus subtilis, is composed of an N-terminal LOV domain (that binds a flavin [FMN]) and a C-terminal STAS domain. This latter domain shows sequence features typical for a... | ['Bacillus subtilis', 'Bacterial Proteins', 'Boron Compounds', 'Cloning, Molecular', 'Escherichia coli', 'Flavin Mononucleotide', 'Fluorescent Dyes', 'Guanosine Triphosphate', 'Light', 'Models, Molecular', 'Open Reading Frames', 'Photochemistry', 'Photoreceptors, Microbial', 'Protein Binding', 'Protein Structure, Terti... | 21,388,385 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['D01.132', 'D02.203'], ['E05.393.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D03.633.100.733.315.650.500', 'D03.633.300.507.650.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Leading causes of death in England and Wales--how should we group causes? | This article examines how best to identify the leading causes of mortality in England an Wales, by using different way of grouping causes of death, based on a list developed by the World Health Organization (WHO). Four different versions of this list are compared. The leading cause of death across all age groups depend... | ['Age Factors', 'Cause of Death', 'England', 'Epidemiologic Methods', 'Female', 'Humans', 'Male', 'Risk Factors', 'Wales', 'World Health Organization'] | 16,315,552 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['Z01.542.363.300'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Effect of dietary proteins on hepatic and plasma lipids, and some properties of major plasma lipoprotein fractions during dietary-induced hypercholesterolemia in male rats. | In order to characterize further the cholesterolemic effect of casein compared with soybean protein isolate, each of these proteins were fed to male rats at different levels of dietary cholesterol administration. An increase in the dietary cholesterol level from zero to 0.25% led to a several-fold increase in plasma tr... | ['Animals', 'Cholesterol', 'Cholesterol, Dietary', 'Dietary Proteins', 'Electrophoresis, Agar Gel', 'Hypercholesterolemia', 'Lipid Metabolism', 'Lipids', 'Lipoproteins', 'Liver', 'Male', 'Rats', 'Rats, Inbred Strains', 'Triglycerides', 'Ultracentrifugation'] | 3,718,994 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.225', 'D10.212.302.347', 'D10.570.938.208.222'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['E05.196.401.153', 'E05.301.300.100'], ['C18.452.584.500.500.396'], ['G03.458'], ['D10'], ['D10.532', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cross-Cultural Validation and Normative Data of the Social Responsiveness Scale in a Group of Iranian General Child Population. | This study aimed to assess the validity and normative statistics of the Farsi version of the Social Responsiveness Scale-2 (SRS-2). Among the mainstream elementary schools, 191 boys and 342 girls with a mean age of 9.46 (+ 1.72) years were recruited. Teachers and parents completed the SRS-2. The parents also answered t... | ['Adolescent', 'Child', 'Child Development Disorders, Pervasive', 'Cross-Cultural Comparison', 'Female', 'Humans', 'Iran', 'Male', 'Parents', 'Psychological Tests', 'Social Behavior', 'Surveys and Questionnaires'] | 30,334,127 | [['M01.060.057'], ['M01.060.406'], ['F03.625.164'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['F04.711'], ['F01.145.813'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.5... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells. | Two major pathways are implicated in the stimulation of insulin secretion by glucose. The K+-ATP channel-dependent pathway involves closure of these channels, depolarization of the beta-cell membrane, acceleration of Ca2+ influx, and a rise in cytosolic free Ca2+ ([Ca2+]i). The K+-ATP channel-independent pathway potent... | ['Adenosine Triphosphate', 'Animals', 'Calcium', 'Diazoxide', 'Exocytosis', 'Female', 'Glucose', 'Glyburide', 'Hypoglycemic Agents', 'Insulin', 'Insulin Secretion', 'Ion Channel Gating', 'Islets of Langerhans', 'Mice', 'Potassium Channels', 'Sulfonylurea Compounds', 'Tolbutamide'] | 10,218,978 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.886.590.700.135.300', 'D02.886.655.500.300', 'D03.633.100.174.300'], ['G04.468'], ['D09.947.875.359.448'], ['D02.065.950.828.575', 'D02.886.590.795.575'], ['D27.505.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methylmercury speciation influences brain gene expression and behavior in gestationally-exposed mice pups. | The greatest source of human exposure to methylmercury (MeHg) is the diet, in particular the consumption of seafood. To investigate the importance of dietary MeHg speciation on neurotoxicity, balb/c mice dams were exposed to MeHgCys (the naturally-occurring salt) and MeHgCl (the laboratory salt), at concentrations up t... | ['Aging', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Animals, Newborn', 'Behavior, Animal', 'Body Burden', 'Brain', 'Cysteine', 'Diet', 'Female', 'Food Contamination', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Gestational Age', 'Maternal Nutritional Physiological Phenomena', 'Mercury Po... | 19,465,457 | [['G07.345.124'], ['G07.203.650.161'], ['B01.050'], ['B01.050.050.282'], ['F01.145.113'], ['E05.799.638.231', 'N06.850.460.200'], ['A08.186.211'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G07.203.650.240'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'],... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effect of a titanium cage as a stand-alone device on biomechanical stability in the lumbosacral spine of canine cadavers. | Degenerative lumbosacral stenosis is a common disease in dogs characterised by intervertebral disc herniation, loss of disc height and stenosis. Decompressive dorsal laminectomy and partial discectomy can cause spinal instability and worsen foraminal stenosis. Pedicle screw and rod fixation (PSRF) with an intervertebra... | ['Animals', 'Biomechanical Phenomena', 'Cadaver', 'Diskectomy', 'Dogs', 'Intervertebral Disc', 'Laminectomy', 'Lumbosacral Region', 'Pedicle Screws', 'Range of Motion, Articular', 'Titanium'] | 28,190,488 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['C23.550.260.224'], ['E02.718.444', 'E04.188.350', 'E04.555.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['E02.718.563', 'E04.188.400', 'E04.525.450', 'E04.555.350'], ['A01.923.176.519'], ['E07.695.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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