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Identification and characterization of mechanistically distinct inducers of gamma-globin transcription. | Inhibition of HbS polymerization is a major target for therapeutic approaches in sickle cell anemia. Toward this goal, initial efforts at pharmacological elevation of fetal hemoglobin (HbF) has shown therapeutic efficacy. In order to identify well-tolerated, novel agents that induce HbF in patients, we developed a high... | ['Anemia, Sickle Cell', 'Enzyme Inhibitors', 'Erythroid Precursor Cells', 'Fetal Hemoglobin', 'Globins', 'Histone Deacetylase Inhibitors', 'Histone Deacetylases', 'Humans', 'K562 Cells', 'RNA, Messenger', 'Transcription, Genetic'] | 14,563,486 | [['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['D27.505.519.389'], ['A11.148.378.590.837.250', 'A11.443.240.497', 'A11.872.378.590.817.250', 'A15.378.316.378.590.837.250'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['D12.776.422.316'], ['D27.505.519.389.360'], ['D08.81... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of the endothelium on contractile responses of arteries from diabetic rats. | Contractile responses of aortas and mesenteric arteries from control and 3 month streptozotocin-diabetic rats to alpha-adrenoceptor agonists were compared in the presence and absence of endothelium. In the presence of endothelium, responses of both arteries from diabetic animals to norepinephrine and methoxamine were e... | ['Acetylcholine', 'Animals', 'Aorta, Thoracic', 'Arteries', 'Clonidine', 'Cyclic GMP', 'Diabetes Mellitus, Experimental', 'Endothelium, Vascular', 'In Vitro Techniques', 'Male', 'Mesenteric Arteries', 'Muscle Contraction', 'Rats', 'Rats, Inbred Strains'] | 2,850,927 | [['D02.092.211.111'], ['B01.050'], ['A07.015.114.056.372'], ['A07.015.114'], ['D03.383.129.308.436.500'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.481'], ['A0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stream macroinvertebrate response models for bioassessment metrics: addressing the issue of spatial scale. | We developed independent predictive disturbance models for a full regional data set and four individual ecoregions (Full Region vs. Individual Ecoregion models) to evaluate effects of spatial scale on the assessment of human landscape modification, on predicted response of stream biota, and the effect of other possible... | ['Animals', 'Invertebrates', 'Models, Theoretical', 'Reproducibility of Results'] | 24,675,770 | [['B01.050'], ['B01.050.500'], ['E05.599'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras. | Levels of p27 have been found to have independent prognostic significance in a variety of tumors including breast, colon, prostate, ovary, and gastric carcinomas. We investigated p27 levels and determined ras mutational status in 136 non-small cell lung cancers. We found reduced levels of p27 in 86% of cases and showed... | ['Carcinoma, Non-Small-Cell Lung', 'Cell Cycle', 'Cell Cycle Proteins', 'Cyclin-Dependent Kinase Inhibitor p27', 'Genes, ras', 'Humans', 'Lung Neoplasms', 'Microtubule-Associated Proteins', 'Mutation', 'Neoplasm Staging', 'Prognosis', 'Tumor Suppressor Proteins'] | 9,973,218 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G04.144'], ['D12.776.167'], ['D12.644.360.225.600', 'D12.776.167.187.600', 'D12.776.476.225.600', 'D12.776.624.776.355.600'], ['G05.360.340.024.340.375.500.791.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fusarium graminearum | Fusarium head blight (FHB) of wheat and barley caused by the fungus Fusarium graminearum reduces crop yield and contaminates grain with mycotoxins. In this study, we investigated two exo-1,5-á-L-arabinanases (Arb93A and Arb93B) secreted by F. graminearum and their effect on wheat head blight development. Arabinan is an... | ['Fungal Proteins', 'Fusarium', 'Glycoside Hydrolases', 'Mutation', 'Mycotoxins', 'Plant Diseases', 'Plant Immunity', 'Triticum'] | 30,759,350 | [['D12.776.354'], ['B01.300.381.366'], ['D08.811.277.450'], ['G05.365.590'], ['D23.946.587'], ['G15.610'], ['G12.450.800', 'G15.630'], ['B01.650.940.800.575.912.250.822.918']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Yields and nutrient content of selected fresh fruits. | Proximate composition, edible yields, and selected nutrients were measured in cantaloupe, cherries, grapes, nectarines, plums, and watermelon sampled in six major U.S. markets. Yields were lowest (about 55%) for the melons, but were much higher (about 90% or above) for other fruits. Fruits were high in moisture, low in... | ['Dietary Carbohydrates', 'Dietary Proteins', 'Fruit', 'Trace Elements', 'Vitamins'] | 3,998,345 | [['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555'], ['D27.505.696.494.600', 'G07.203.300.681.500.600', 'J02.500.681.500.600']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of working environment contaminated with organic solvents on the activity of acid phosphatase in lymphocytes. | In 108 workers occupationally exposed to organic solvents containing benzene, toluene and xylene, the activity of acid phosphatase (AP) was determined in the peripheral blood lymphocytes. A positive correlation was found between the number of lymphocytes exhibiting redistribution of AP from lysosomes into the cytoplasm... | ['Acid Phosphatase', 'Adult', 'Aged', 'Air Pollutants', 'Air Pollutants, Occupational', 'Benzene', 'Female', 'Humans', 'Lymphocytes', 'Male', 'Middle Aged', 'Solvents', 'Toluene', 'Xylenes'] | 6,844,841 | [['D08.811.277.352.650.025'], ['M01.060.116'], ['M01.060.116.100'], ['D27.888.284.101'], ['D27.888.284.101.268'], ['D02.455.426.559.389.023'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['M01.060.116.630'], ['D27.720.844'], ['D02.455.426.5... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Increasing the Morphological Stability of DNA-Templated Nanostructures with Surface Hydrophobicity. | DNA has been extensively used as a versatile template to assemble inorganic nanoparticles into complex architectures; thanks to its programmability, stability, and long persistence length. But the geometry of self-assembled nanostructures depends on a complex combination of attractive and repulsive forces that can over... | ['DNA', 'Drug Stability', 'Gold', 'Hydrophobic and Hydrophilic Interactions', 'Metal Nanoparticles', 'Nanostructures', 'Nanotechnology', 'Particle Size', 'Polyethylene Glycols', 'Polymerization', 'Polymers', 'Surface Properties'] | 26,395,441 | [['D13.444.308'], ['E05.916.330'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['G02.409'], ['J01.637.512.600.500'], ['J01.637.512'], ['H01.603', 'J01.897.520.600'], ['G02.712'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['G02.750'], ['D05.750', 'D25.720', 'J01.637.051... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Dendritic cells derived from murine colonic mucosa have unique functional and phenotypic characteristics. | Dendritic cells (DCs) residing in different tissues and exposed to different organisms are likely to have different reactivities to their surrounding environment. Many studies use in vitro generated DCs to examine functions of these cells, but such cells may not truly reflect the nature of DCs and their in situ activit... | ['Animals', 'CD11b Antigen', 'CD11c Antigen', 'Colon', 'DNA', 'Dendritic Cells', 'Female', 'Gene Expression', 'Intestinal Mucosa', 'Lymphocyte Activation', 'Male', 'Mice', 'Mice, Inbred Strains', 'Oligodeoxyribonucleotides', 'Phenotype', 'T-Lymphocytes', 'Toll-Like Receptors'] | 17,548,635 | [['B01.050'], ['D12.776.395.550.200.074.750', 'D12.776.543.550.200.093.750', 'D12.776.543.750.705.408.100.150', 'D12.776.543.750.705.833.062', 'D23.050.301.350.074.049'], ['D12.776.395.550.200.074.875', 'D12.776.395.550.200.275.500', 'D12.776.543.550.200.093.875', 'D12.776.543.550.200.275.500', 'D12.776.543.750.705.408... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of water stress on lupin stem protein analysed by two-dimensional gel electrophoresis. | Lupinus albus plants can withstand severe drought stress and show signs of recovery 24 h after rewatering (RW). Two-dimensional gel electrophoresis was used to evaluate the effect of water deficit (WD) on the protein composition of the two components of the lupin stem (stele and cortex). This was performed at three dis... | ['Amino Acid Sequence', 'Electrophoresis, Gel, Two-Dimensional', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Lupinus', 'Molecular Sequence Data', 'Plant Proteins', 'Plant Stems', 'Water'] | 15,668,768 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.401.250', 'E05.301.300.230'], ['E05.393.332'], ['G05.308.375'], ['B01.650.940.800.575.912.250.401.571'], ['L01.453.245.667'], ['D12.776.765'], ['A18.024.937'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The unfolded protein response has a protective role in yeast models of classic galactosemia. | Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase. Here we show that the unfolded protein response pathway is triggered by galactose in two yeast models of galactosemia: lithium-treated cell... | ['Alternative Splicing', 'Basic-Leucine Zipper Transcription Factors', 'Endoplasmic Reticulum', 'Fungal Proteins', 'Galactokinase', 'Galactose', 'Galactosemias', 'Galactosephosphates', 'Gene Expression Regulation, Fungal', 'Glycoproteins', 'HSP70 Heat-Shock Proteins', 'Humans', 'Mutation', 'Oxidoreductases Acting on Su... | 24,077,966 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['D12.776.260.108', 'D12.776.930.127'], ['A11.284.430.214.190.875.248'], ['D12.776.354'], ['D08.811.913.696.620.240'], ['D09.947.875.359.377'], ['C10.228.140.163.100.320', 'C16.320.565.189.320', 'C16.320.565.202.355', 'C18.452.132.100.320', 'C18.452.64... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health-Related Quality of Life and Psychological Adjustment of Children and Adolescents with Pacemakers and Implantable Cardioverter Defibrillators: A Systematic Review. | The absence of cardiac symptoms, the improved exercise tolerance and the increased life expectancy are the advantages of a successful cardiac device therapy. Nevertheless, the fact of a lifelong device dependency, the inherent possibility of device malfunction and the progression of the underlying heart disease may imp... | ['Adolescent', 'Anxiety', 'Child', 'Defibrillators, Implantable', 'Depression', 'Emotional Adjustment', 'Female', 'Humans', 'Male', 'Pacemaker, Artificial', 'Quality of Life'] | 30,539,238 | [['M01.060.057'], ['F01.470.132'], ['M01.060.406'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['F01.145.126.350'], ['F01.058.144', 'F01.752.543.500.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.305.250.750'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Study on surgical treatment of intractable childhood epilepsy. | We studied the clinical details of 14 children with intractable epilepsies, all of whom underwent epilepsy surgery before age 18 years. All 14 suffered catastrophic seizures, which were resistant to the full range of available medical treatments. The ages at operation ranged from 4 years 7 months to 17 years 2 months, ... | ['Adolescent', 'Adult', 'Brain', 'Child', 'Child, Preschool', 'Electroencephalography', 'Epilepsy', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Postoperative Complications', 'Prognosis', 'Radiography', 'Tomography, Emission-Computed, Single-Photon', 'Treatment Outcome'] | 9,628,191 | [['M01.060.057'], ['M01.060.116'], ['A08.186.211'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C23.550.767'], ['E01.789'], ['E01.370.350.700'], ['E01.370.350.350.800.800', 'E01.370.350.600... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats. | Dexamethasone (DEX), a synthetic corticosteroid, has been successfully used in clinical practice during paraquat (PQ) poisonings due to its anti-inflammatory activity, although, as recently observed, its effects related to de novo synthesis of P-glycoprotein (P-gp), may also strongly contribute for its healing effects.... | ['Acetylglucosaminidase', 'Animals', 'Anti-Inflammatory Agents', 'Dexamethasone', 'Dose-Response Relationship, Drug', 'Herbicides', 'Kidney', 'Lipid Peroxidation', 'Liver', 'Lung', 'Male', 'Microscopy, Electron, Transmission', 'Organ Size', 'Paraquat', 'Peroxidase', 'Protein Carbonylation', 'Rats', 'Rats, Wistar', 'Spl... | 16,956,706 | [['D08.811.277.450.483.180.500'], ['B01.050'], ['D27.505.954.158'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.720.031.700.366', 'D27.888.723.366'], ['A05.810.453'], ['G02.111.515', 'G03.295.531.587'], ['A03.620'], ['A04.411'], ['E01.370.350.515.402.580', 'E05.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Asymmetric synthesis of (+)-altholactone: a styryllactone isolated from various Goniothalamus species. | The asymmetric total synthesis of (+)-altholactone (1), a member of the styryllactone family of natural products displaying cytotoxic and antitumor activities, is described. Key steps include a RAMP-hydrazone alpha-alkylation (RAMP=(R)-1-amino-2-methoxymethylpyrrolidine) of 2,2-dimethyl-1,3-dioxan-5-one, a boron-mediat... | ['Antineoplastic Agents', 'Furans', 'Goniothalamus', 'Molecular Conformation', 'Pyrones', 'Stereoisomerism'] | 18,219,645 | [['D27.505.954.248'], ['D03.383.312'], ['B01.650.940.800.575.912.250.065.812'], ['G02.111.570.820'], ['D03.383.663.718'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of chitin synthase 2 of Saccharomyces cerevisiae. II: Both full size and processed enzymes are active for chitin synthesis. | When chitin synthase 2 of Saccharomyces cerevisiae was overexpressed in yeast cells using GAL1 promoter, deletion of the N-terminal 193 amino acids significantly increased the level of the protein without affecting its characteristics. We partially purified N-terminally truncated chitin synthase 2 by product entrapment... | ['Antibodies, Fungal', 'Antibodies, Monoclonal', 'Base Sequence', 'Binding Sites', 'Cations, Divalent', 'Cell Membrane', 'Chitin', 'Chitin Synthase', 'Chymotrypsin', 'Enzyme Activation', 'Enzyme Precursors', 'Gene Expression', 'Molecular Sequence Data', 'Molecular Weight', 'Protein Processing, Post-Translational', 'Rec... | 8,743,566 | [['D12.776.124.486.485.114.179', 'D12.776.124.790.651.114.179', 'D12.776.377.715.548.114.179'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D01.248.497.300.333'], ['A11.284.149'], ['D05.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
One stage percutaneous transhepatic biliary stenting for malignant jaundice: a safe, quick and economical option of treatment. | OBJECTIVE: Patients with proximal malignant jaundices are often diagnosed in an advanced stage and need biliary decompression treatments, such as percutaneous transhepatic biliary drainage (PTBD) and bare metal stenting (BMS), to improve the hepatic function. Whether it is better to perform those two procedures togethe... | ['Aged', 'Aged, 80 and over', 'Bile Duct Neoplasms', 'Biliary Tract Surgical Procedures', 'Cholangiopancreatography, Magnetic Resonance', 'Cost-Benefit Analysis', 'Decompression, Surgical', 'Drainage', 'Female', 'Humans', 'Jaundice, Obstructive', 'Klatskin Tumor', 'Length of Stay', 'Male', 'Middle Aged', 'Retrospective... | 31,539,161 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['E04.210.120'], ['E01.370.350.825.500.100', 'E01.370.372.207'], ['N03.219.151.125'], ['E04.188'], ['E02.309', 'E04.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.429.500.7... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Henoch-Sch?nlein purpura complicating staphylococcal endocarditis in a heroin addict. | A 21-year-old heroin addict with right-sided staphylococcal endocarditis developed skin purpura, abdominal pain, bloody diarrhea, proteinuria and microscopic hematuria. Skin biopsy showed leukocytoclastic vasculitis with IgA deposits in dermal vessels and renal biopsy disclosed proliferative glomerulonephritis with gra... | ['Adult', 'Cloxacillin', 'Endocarditis, Bacterial', 'Heroin Dependence', 'Humans', 'Male', 'Purpura, Schoenlein-Henoch', 'Staphylococcal Infections', 'Staphylococcus aureus'] | 3,605,234 | [['M01.060.116'], ['D02.065.589.099.750.625.150', 'D02.886.108.750.625.150', 'D03.633.100.300.750.625.150'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['C25.775.643.500.400', 'F03.900.647.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.940.777', 'C15.378.100.802.375', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Trans-sternal titanium fixation bars: an initial experience with 28 patients. | A clinical experience is described with the use of titanium trans-sternal fixation bars to achieve either primary or secondary sternal closure and stability using the principle of rigid fixation in high-risk and wound salvage sternotomy patients. The purpose of rigid fixation in those situations is not only to achieve ... | ['Adult', 'Humans', 'Internal Fixators', 'Middle Aged', 'Sternotomy', 'Surgical Wound Dehiscence', 'Surgical Wound Infection', 'Titanium', 'Treatment Outcome', 'Wound Closure Techniques'] | 22,722,643 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.370', 'E07.858.442.660.460', 'E07.858.690.725.460'], ['M01.060.116.630'], ['E04.928.710'], ['C23.550.767.887'], ['C01.947.692', 'C23.550.767.925'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800'], ['E01.789.800', 'N04.761.559.590.800... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Bimatoprost in the treatment of ocular hypertension and chronic glaucoma]. | PURPOSE: The aim of this study was to evaluate the efficacy and the safety of bimatoprost in an outpatient glaucoma practice and to correlate the responsiveness to this treatment with the central corneal thickness.MATERIALS AND METHODS: Our retrospective analysis included 55 consecutive patients (mean age, 66 years). B... | ['Adolescent', 'Adrenergic beta-Antagonists', 'Adult', 'Aged', 'Aged, 80 and over', 'Amides', 'Analysis of Variance', 'Antihypertensive Agents', 'Bimatoprost', 'Chi-Square Distribution', 'Cloprostenol', 'Cornea', 'Corneal Topography', 'Female', 'Follow-Up Studies', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressur... | 15,883,493 | [['M01.060.057'], ['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.065'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.411.162'], ['D02.065.141', 'D10.251.355.255.550.775.500.175.250', 'D23.469.050.17... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ex situ preparation of left split-liver grafts with left vascular pedicle only: is it safe? A comparative single-center study. | The procurement of left-lateral-segment grafts from living donors for transplantation in children is performed by retaining only the left branches of the artery and veins. New techniques and the implementation of microsurgery in the transplant operation made this procedure a successful approach. However, controversy pe... | ['Adolescent', 'Adult', 'Child', 'Graft Survival', 'Humans', 'Liver', 'Liver Transplantation', 'Middle Aged'] | 12,451,236 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.060.116.630']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A longitudinal laser fluorescence study of white spot lesions in orthodontic patients. | Orthodontic treatment with fixed appliances increases the caries risk in young persons. The aim of this study was to apply a new caries diagnostic method, quantitative laser fluorescence, for longitudinal in vivo quantification of changes in incipient enamel lesions related to fixed orthodontic appliances. Seven young ... | ['Adolescent', 'Cariostatic Agents', 'Counseling', 'Dental Caries', 'Dental Caries Susceptibility', 'Dental Enamel', 'Dentifrices', 'Feeding Behavior', 'Fluorescence', 'Fluorides', 'Follow-Up Studies', 'Humans', 'Image Processing, Computer-Assisted', 'Lasers', 'Longitudinal Studies', 'Oral Hygiene', 'Orthodontic Bracke... | 9,637,561 | [['M01.060.057'], ['D25.223', 'D27.505.696.706.222', 'D27.720.102.223', 'D27.720.799.113', 'J01.637.051.223'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['C07.793.720.210'], ['G10.549.140'], ['A14.549.167.900.255'], ['D25.376', 'D27.720.269.380', 'J01.637.051.376'], ['F01.145.113.547', 'F01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Identification of resected root-end dentinal cracks: a comparative study of visual magnification. | The purpose of this in vitro study was to evaluate and compare the effectiveness of visual enhancements as aids in identifying artificially created dentinal cracks in resected root ends. Fifty human maxillary central incisors were decoronated, and the root canals were instrumented to ISO size 50 at the working length. ... | ['Analysis of Variance', 'Dentin', 'Endoscopes', 'Humans', 'Incisor', 'Lenses', 'Microscopy', 'Reproducibility of Results', 'Root Canal Preparation', 'Sensitivity and Specificity', 'Tooth Apex', 'Tooth Fractures', 'Vision, Ocular'] | 12,929,699 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A14.549.167.900.280'], ['E07.230.220', 'E07.858.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['E07.632.500'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma. | : TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squamo... | ['Animals', 'Biomarkers, Tumor', 'Carcinogenesis', 'Carcinoma, Squamous Cell', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'DNA Methylation', 'DNA-Binding Proteins', 'Gene Expression Regulation, Neoplastic', 'Head and Neck Neoplasms', 'Humans', 'Keratinocytes', 'Keratins', 'Mice', 'Mice, Nude', 'Neoplasm... | 30,389,700 | [['B01.050'], ['D23.101.140'], ['C04.697.098', 'C23.550.727.098'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D12.776.260'], ['G05.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal diagnosis of methotrexate embryopathy. | BACKGROUND: Methotrexate is an antineoplastic agent used by obstetrician-gynecologists for termination of early pregnancy. The drug is not always successful and is associated with a known array of malformations.CASE: We present a case of a failed pregnancy termination with methotrexate, which resulted in fetal anomalie... | ['Abnormalities, Drug-Induced', 'Abortifacient Agents, Nonsteroidal', 'Abortion, Induced', 'Adult', 'Female', 'Humans', 'Methotrexate', 'Pregnancy', 'Treatment Failure', 'Ultrasonography, Prenatal'] | 12,738,117 | [['C16.131.042'], ['D27.505.696.875.131.100', 'D27.505.954.705.131.100'], ['E04.520.050'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.733.631.192.500'], ['G08.686.784.769'], ['E01.789.800.760', 'N04.761.559.590.800.760', 'N05.715.360.575.575.800.760'], ['E01.370.350.850.865', 'E01.3... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Investigation of heavy metal pollution in eastern Aegean Sea coastal waters by using Cystoseira barbata, Patella caerulea, and Liza aurata as biological indicators. | In order to have an extensive contamination profile of heavy metal levels (Cd, Cu, Fe, Mn, Ni, Pb, and Zn), seawater, sediment, Patella caerulea, Cystoseira barbata, and Liza aurata were investigated by using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Samples were collected from five coastal sta... | ['Animals', 'Environmental Monitoring', 'Fishes', 'Gastropoda', 'Metals, Heavy', 'Phaeophyta', 'Water Pollutants, Chemical'] | 28,105,592 | [['B01.050'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.493'], ['B01.050.500.644.400'], ['D01.268.556', 'D01.552.544'], ['B01.750.600'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Metabolic syndrome and mortality in the elderly: a time-dependent association. | AIMS: To evaluate the association between metabolic syndrome (MetS) components and mortality over time.METHODS: 3086 residents aged ?49 years were followed in the Blue Mountains Eye Study, Australia. MetS components as defined by the International Diabetes Federation criteria were measured at baseline (1992-1994), 5-ye... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Proportional Hazards Models', 'Risk Factors'] | 23,206,672 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500.570', 'C18.452.625'], ['M01.060.116.630'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.998.825', 'E05.599.835.900', 'N05.715.360.750.530.650', 'N05.715.360.750.625... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Object correspondence: Using perceived causality to infer how the visual system knows what went where. | Anne Treisman and colleagues developed an influential theoretical framework surrounding the construct of "object files" as a means of understanding the functional need for an episodic representation of objects as they move, change, disappear, and reappear from view (Kahneman, Treisman, & Gibbs, Cognitive Psychology, 24... | ['Humans', 'Pattern Recognition, Visual', 'Psychological Theory'] | 31,214,971 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.739']] | ['Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An observational registry on efficacy and safety of the right ventricular outflow tract as a site for ICD leads: results of the EFFORT (EFFicacy Of Right ventricular outflow Tract as site for ICD leads) registry. | BACKGROUND: Although pacing from the right ventricular outflow tract (RVOT) has been shown to be safe and feasible in terms of sensing and pacing thresholds, its use as a site for implantable cardioverter defibrillator (ICD) leads is not common. This is probably due to physicians' concerns about defibrillation efficacy... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cardiac Pacing, Artificial', 'Cardiomyopathies', 'Defibrillators, Implantable', 'Electric Countershock', 'Equipment Design', 'Female', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Registries', 'Ventricular Function, Right'] | 20,577,792 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.331.200'], ['C14.280.238'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['E02.331.350'], ['E05.320'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Consumers' increasing influence on health care. | The individual consumer's new predominance in the health care marketplace is increasingly influencing policy, strategy, operations, and investment decisions of health care organizations within all segments of the industry. A recent survey has some surprising things to say about the consumer's increasingly influential r... | ['Attitude of Health Personnel', 'Community Participation', 'Consumer Behavior', 'Health Care Sector', 'Health Care Surveys', 'Humans', 'United States'] | 10,181,303 | [['F01.100.050', 'N05.300.100'], ['N02.421.143.212', 'N03.540.245.360'], ['F01.145.236'], ['J01.576.489', 'N03.219.650'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Are diurnal and nocturnal intraocular pressure measurements over 48 h justified?]. | PURPOSE: Diurnal intraocular pressure (IOP) measurements are recommended in cases of visual field deterioration in glaucoma patients. In this study the rationale of 24 h versus 48 h IOP measurements was investigated.PATIENTS AND METHODS: Mean IOP and maximum IOP values were obtained in 80 patients over a period of 48 h... | ['Aged', 'Circadian Rhythm', 'Diagnosis, Computer-Assisted', 'Female', 'Glaucoma', 'Humans', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Ocular Hypertension', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Tonometry, Ocular'] | 23,354,356 | [['M01.060.116.100'], ['G07.180.562.190'], ['E01.158', 'L01.313.500.750.100.158'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['M01.060.116.630'], ['C11.525'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. | Direct and indirect involvement of receptor tyrosine kinases (RTKs) in tumor growth and metastasis makes them ideal targets for anticancer therapy. A paradigm shift from inhibition of single RTK to inhibition of multiple RTKs has been recently demonstrated. We designed and synthesized eight N(4)-phenylsubstituted-6-(2-... | ['Angiogenesis Inhibitors', 'Animals', 'Cell Line, Tumor', 'Cell Proliferation', 'Chick Embryo', 'Chorioallantoic Membrane', 'Drug Design', 'Drug Screening Assays, Antitumor', 'ErbB Receptors', 'Humans', 'Models, Molecular', 'Molecular Structure', 'Protein Kinase Inhibitors', 'Pyrimidines', 'Pyrroles', 'Receptor Protei... | 18,467,105 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A13.350.150', 'A16.331.200'], ['A10.615.284.375', 'A13.350.575', 'A16.331.400'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Toxicological study of Semecarpus anacardium nut extract. | Toxicological study was carried out in rats with chloroform-soluble fraction of the nuts of Semecarpus anacardium to determine its safe non-toxic dose. The fraction produced toxicity at all levels tested (50-400 mg/kg) but the extent of toxicity was found dose-dependent. At lower doses this fraction induced partial gro... | ['Animals', 'Behavior, Animal', 'Body Weight', 'Lethal Dose 50', 'Male', 'Nuts', 'Plant Extracts', 'Plants, Medicinal', 'Rats', 'Time Factors'] | 489,092 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The reinforcing efficacy of alcohol mediates associations between impulsivity and negative drinking outcomes. | OBJECTIVE: One predictor of negative drinking outcomes in college populations is impulsivity. Individual differences in the reinforcing efficacy of alcohol, which reflects willingness to drink despite potential costs, may serve as a mechanism by which impulsivity is associated with alcohol-related problems. The purpose... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcohol-Related Disorders', 'Alcoholic Beverages', 'Commerce', 'Cross-Sectional Studies', 'Female', 'Humans', 'Impulsive Behavior', 'Male', 'Reinforcement, Psychology', 'Students', 'Universities', 'Young Adult'] | 23,490,580 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C25.775.100', 'F03.900.100'], ['G07.203.100.100', 'J02.200.100'], ['J01.219'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['F02.463.425.770'], ['M01.848'], ['I0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Feasibility and Impact of a Multicomponent Exercise Intervention in Patients With Alzheimer's Disease: A Pilot Study. | This quasi-experimental, nonrandomized study examined the feasibility and impact of a multicomponent (MT) intervention on 7 community-dwelling individuals diagnosed with probable Alzheimer's disease (AD) at mild to moderate stage. During 6 months, patients with AD and their caregivers were submitted to a biweekly exerc... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Cardiorespiratory Fitness', 'Caregivers', 'Exercise Therapy', 'Feasibility Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Muscle Strength', 'Outcome and Process Assessment, Health Care'] | 30,525,876 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['G11.427.685.500', 'I03.450.642.845.054.300', 'I03.450.642.845.054.800.500', 'N01.400.150', 'N01.400.545.500'], ['M01.085', 'M01.526.48... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Alcohol consumption, masculinity, and alcohol-related violence and anti-social behaviour in sportspeople. | OBJECTIVES: There is no research examining alcohol-related aggression and anti-social behaviour in UK or European sportspeople (athletes), and no research has examined relationships between masculinity, alcohol consumption, and alcohol-related aggression and antisocial behaviour in sportspeople (athletes). This study a... | ['Aggression', 'Alcohol Drinking', 'Athletes', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Masculinity', 'United Kingdom', 'Universities', 'Violence', 'Young Adult'] | 29,338,922 | [['F01.145.126.125', 'F01.145.813.045'], ['F01.145.317.269'], ['M01.072'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.376', 'F01.393.446.250.750', 'F01.752.747.385.200.750'], ['Z01.542.363'], ['I02.783.830', 'J03.832.830'... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Annual injection of vitamin D and fractures of aged bones. | In order to investigate the effect of a supplementation of vitamin D in the prophylaxis of fractures of the bones of aged people, an annual intramuscular injection of ergocalciferol (150,000-300,000 IU) was given to two series of aged subjects: first to 199 (45 male) of 479 subjects (110 male) aged more than 85 years w... | ['Aged', 'Aging', 'Ergocalciferols', 'Female', 'Fractures, Bone', 'Humans', 'Incidence', 'Male', 'Osteoporosis, Postmenopausal', 'Prospective Studies', 'Sex Factors'] | 1,422,948 | [['M01.060.116.100'], ['G07.345.124'], ['D04.210.500.247.222.474', 'D04.210.500.247.808.412', 'D04.210.500.812.768.462', 'D10.570.938.439'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phase I clinical trial of an injectable contraceptive for the male. | Earlier studies on the rat and the monkey had demonstrated that an injection of styrene maleic anhydride (SMA) in a solvent vehicle of dimethyl sulphoxide (DMSO) into the lumen of the vas deferens is toxicologically safe and has contraceptive action. Phase I clinical trial was therefore undertaken on 38 male volunteers... | ['Adult', 'Contraceptive Agents, Male', 'Dimethyl Sulfoxide', 'Dose-Response Relationship, Drug', 'Humans', 'Injections', 'Male', 'Sperm Count', 'Styrenes', 'Vas Deferens'] | 8,222,664 | [['M01.060.116'], ['D27.505.696.875.360.443', 'D27.505.954.705.360.443'], ['D02.886.640.150'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Entamoeba histolytica modulates TNF-alpha, IL-1 alpha/beta and c-fos gene expression in macrophages. | E. histolytica infections induce a state of transient suppression of cell-mediated immunity. As macrophages are involved in host defense in amebiasis, we determined whether soluble amebic lysates (Eh) can modulate TNF-alpha, IL-1 alpha/beta and c-fos gene expression in naive bone marrow-derived macrophages (BM delta). ... | ['Animals', 'Bone Marrow Cells', 'Cell Extracts', 'Entamoeba histolytica', 'Female', 'Gene Expression Regulation', 'Genes, fos', 'Interleukin-1', 'Lipopolysaccharides', 'Macrophage Activation', 'Macrophages', 'Mice', 'Mice, Inbred BALB C', 'Proto-Oncogene Proteins c-fos', 'Tumor Necrosis Factor-alpha'] | 1,340,279 | [['B01.050'], ['A11.148', 'A15.378.316'], ['D20.777.162'], ['B01.046.500.100.700.335.330'], ['G05.308'], ['G05.360.340.024.340.375.500.791.330'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['D09.400.500', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in pulmonary blood flow during gaseous and partial liquid ventilation in experimental acute lung injury. | BACKGROUND: It has been proposed that partial liquid ventilation (PLV) causes a compression of the pulmonary vasculature by the dense perfluorocarbons and a subsequent redistribution of pulmonary blood flow from dorsal to better-ventilated middle and ventral lung regions, thereby improving arterial oxygenation in situa... | ['Animals', 'Fluorocarbons', 'Hemodynamics', 'Liquid Ventilation', 'Lung', 'Lung Injury', 'Models, Animal', 'Pulmonary Circulation', 'Pulmonary Gas Exchange', 'Respiratory Distress Syndrome', 'Swine', 'Tomography, Emission-Computed, Single-Photon'] | 11,149,439 | [['B01.050'], ['D02.455.526.510.435'], ['G09.330.380'], ['E02.041.625.525', 'E02.880.820.525'], ['A04.411'], ['C08.381.520', 'C26.891.554'], ['E05.598'], ['G09.330.100.770', 'G09.772.593'], ['E01.370.386.700.650', 'G03.143.775.602', 'G09.772.705.760.602'], ['C08.381.840', 'C08.618.840'], ['B01.050.150.900.649.313.500.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biodegradation of propargite by Pseudomonas putida, isolated from tea rhizosphere. | Biodegradation of miticide propargite was carried out in vitro by selected Pseudomonas strains isolated from tea rhizosphere. A total number of 13 strains were isolated and further screened based on their tolerance level to different concentrations of propargite. Five best strains were selected and further tested for t... | ['Culture Media', 'Cyclohexanes', 'Pseudomonas putida', 'Tea'] | 19,892,461 | [['D27.720.470.305', 'E07.206'], ['D02.455.426.392.368.367'], ['B03.440.400.425.625.625.675', 'B03.660.250.580.590.580'], ['D20.215.784.844', 'G07.203.100.831', 'J02.200.831']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Knockout of CTNNB1 by CRISPR-Cas9 technology inhibits cell proliferation through the Wnt/â-catenin signaling pathway. | OBJECTIVE: To study the effects of CTNNB1 gene knockout by CRISPR-Cas9 technology on cell adhesion, proliferation, apoptosis, and Wnt/â-catenin signaling pathway.RESULTS: CTNNB1 gene of HEK 293T cells was knocked out by CRISPR-Cas9. This was confirmed by sequencing and western blotting. Methylthiazolyl-tetrazolium brom... | ['Apoptosis', 'CRISPR-Cas Systems', 'Cell Adhesion', 'Cell Proliferation', 'Gene Editing', 'HEK293 Cells', 'Humans', 'Wnt Signaling Pathway', 'beta Catenin'] | 29,249,062 | [['G04.146.954.035'], ['G05.308.203.374.394'], ['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.393.420.270'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.925', 'G04.835.925'], ['D12.776.091.249', 'D12.776.220.145.500', 'D12.776.930.130']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases. | This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-beta-lactamase inhibitors. Natural product screening of the Bacillus cereus II enzyme identified an extract from a strain of Chaetomium funicola with inhibitory activity against metallo-beta-lactamases.... | ['Bacillus', 'Bacillus cereus', 'Binding Sites', 'Chaetomium', 'Drug Synergism', 'Enzyme Inhibitors', 'Fermentation', 'Heterocyclic Compounds, 3-Ring', 'Kinetics', 'Meropenem', 'Microbial Sensitivity Tests', 'Models, Molecular', 'Thienamycins', 'beta-Lactamase Inhibitors', 'beta-Lactamases'] | 12,019,104 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['B03.300.390.400.158.218.252', 'B03.353.500.100.218.252', 'B03.510.100.100.218.252', 'B03.510.415.400.158.218.252', 'B03.510.460.410.158.218.252'], ['G02.111.570.120'], ['B01.300.107.800.15... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of resistance to change in children with autism. | "Resistance to change" represents a core symptom of autism that we conceptualized and assessed as resulting in part due to factors known to govern free-operant choice. During a free-choice baseline, participants chose between problematic, resistive responses and an appropriate alternative response. During the asymmetri... | ['Autistic Disorder', 'Behavior Therapy', 'Child', 'Child, Preschool', 'Humans', 'Male', 'Reinforcement, Psychology'] | 31,219,184 | [['F03.625.164.113.500'], ['F04.754.137'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.770']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry. | The determination of intracellular triphosphate metabolites of nucleoside analogs used in anti-HIV therapy is very challenging. Despite the well-known sensitivity and selectivity of LC-MS/MS, the measurement of the triphosphate metabolite of zidovudine (AZT-TP) remains difficult because of the interferences induced by ... | ['Cells, Cultured', 'Chromatography, High Pressure Liquid', 'Dideoxynucleotides', 'Humans', 'Leukocytes, Mononuclear', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, Mass, Electrospray Ionization', 'Thymine Nucleotides', 'Zidovudine'] | 17,238,240 | [['A11.251'], ['E05.196.181.400.300'], ['D13.695.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques. | The tumor necrosis factor (TNF)-alpha converting enzyme (TACE) can cleave the cell-surface ectodomain of the amyloid-beta precursor protein (APP), thus decreasing the generation of amyloid-beta (Abeta) by cultured non-neuronal cells. While the amyloidogenic processing of APP in neurons is linked to the pathogenesis of ... | ['ADAM Proteins', 'ADAM17 Protein', 'Alzheimer Disease', 'Amyloid beta-Peptides', 'Brain', 'Cell Extracts', 'Humans', 'Metalloendopeptidases', 'Neurons', 'Plaque, Amyloid', 'Reference Values', 'Tissue Distribution', 'Tumor Cells, Cultured'] | 11,536,196 | [['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['D08.811.277.656.675.374.102.375', 'D09.400.430.500.375', 'D12.776.395.033.375'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['A08.186.211'], ['D20.777.162'], [... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behavioural effects of quinpirole following withdrawal of chronic treatment with the CB1 agonist, HU-210, in rats. | The present study investigated spontaneous and quinpirole-induced motor responses of in rats, following withdrawal from chronic treatment with the potent cannabinoid agonist HU-210. Withdrawal from chronic HU-210 (20 microg/kg daily, 14 days) produced a decrease in spontaneous activity at 1 and 2 days and enhanced the ... | ['Animals', 'Behavior, Animal', 'Dopamine Agonists', 'Dose-Response Relationship, Drug', 'Dronabinol', 'Male', 'Motor Activity', 'Quinpirole', 'Rats', 'Rats, Wistar', 'Receptor, Cannabinoid, CB1', 'Substance Withdrawal Syndrome', 'Time Factors'] | 16,148,449 | [['B01.050'], ['F01.145.113'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.849.090.810'], ['F01.145.632', 'G11.427.410.698'], ['D03.633.100.810.842', 'D03.633.300.802'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.9... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. | The metabolism of arachidonic acid (ARA) by cytochrome P450 ù/ù-1-hydroxylases leads to the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which is an important lipid-signaling molecule involved in regulation of vascular tone, angiogenesis, and inflammation. Development of a simple method to prepare 20-HETE wo... | ['Animals', 'Arachidonic Acid', 'Ascomycota', 'Cytochrome P-450 Enzyme System', 'Gene Knockout Techniques', 'Hydroxyeicosatetraenoic Acids', 'Hydroxylation', 'Hydroxysteroid Dehydrogenases', 'Mice', 'Neovascularization, Physiologic', 'Oxidation-Reduction'] | 23,966,667 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['B01.300.107'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['E05.393.335.750'], ['D10.251.355.255.100.300', 'D10.251.355.310.166.550'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['D08.811.682.047.436'], ['B01.050.150.900.649... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Terbium binding to ribosomes and ribosomal RNA. | Terbium binding to rat liver ribosomes and ribosomal RNA (rRNA) was examined by equilibrium dialysis and fluorescence spectroscopy. Upon binding to ribosomes and rRNA, the enhancement of terbium fluorescence emission at both 488 and 541 nm was dependent only upon the amount of bound terbium and independent of ionic str... | ['Animals', 'Binding Sites', 'Dialysis', 'Female', 'Liver', 'Osmolar Concentration', 'Potassium Chloride', 'RNA, Ribosomal', 'Rats', 'Ribosomes', 'Spectrometry, Fluorescence', 'Terbium'] | 1,182,126 | [['B01.050'], ['G02.111.570.120'], ['E05.196.353', 'G02.186'], ['A03.620'], ['G02.640'], ['D01.210.450.150.750', 'D01.745.625'], ['D13.444.735.686'], ['B01.050.150.900.649.313.992.635.505.700'], ['A11.284.430.214.190.875.811'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['D01.268.558.362.968', 'D01.552.550.399.968... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering. | AIM: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts.MA... | ['Blood Vessels', 'Cell Differentiation', 'Fibroins', 'Humans', 'Mesenchymal Stem Cells', 'Myocytes, Smooth Muscle', 'Nanofibers', 'Polyesters', 'Tissue Engineering', 'Tissue Scaffolds', 'Vascular Endothelial Growth Factor A'] | 30,526,272 | [['A07.015'], ['G04.152'], ['D05.750.078.875.500', 'D12.776.093.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['A11.620.520'], ['J01.637.512.300'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728'], ['E05.481.500.311.500', 'J01.293.069.249.500'], ['E07.206.627',... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Survival patterns for malignant mesothelioma: the SEER experience. | Statistical analyses of 1,475 histologically confirmed cases of malignant mesothelioma ascertained through the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute for the years 1973-1984 showed age at diagnosis, sex, stage of disease, type of treatment, and geographic area of resi... | ['Adult', 'Age Factors', 'Aged', 'Asbestos', 'Female', 'Humans', 'Male', 'Mesothelioma', 'Middle Aged', 'Sex Factors'] | 3,356,487 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D01.578.725.050', 'D01.837.725.700.760.070'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['M01.060.116.630'], ['N05.715.350.675', 'N06.850.490.875']] | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visceral adiposity in the first half of pregnancy predicts newborn weight among adolescent mothers. | OBJECTIVE: Maternal obesity is a strong risk factor for gestational diabetes mellitus and fetal macrosomia. We assessed the association between maternal visceral adiposity tissue (VAT) depth in the first half of pregnancy and both glucose tolerance in late pregnancy and newborn weight in pregnant adolescents.METHODS: W... | ['Adolescent', 'Birth Weight', 'Body Mass Index', 'Brazil', 'Cohort Studies', 'Comparative Effectiveness Research', 'Female', 'Fetal Weight', 'Gestational Age', 'Glucose Tolerance Test', 'Humans', 'Infant, Newborn', 'Intra-Abdominal Fat', 'Obesity', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Complications', '... | 24,007,705 | [['M01.060.057'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.757.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750',... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Gastrointestinal microbiota and local inflammation during oxazolone-induced dermatitis in BALB/cA mice. | At present, laboratory animals are not standardized with regard to the gastrointestinal microbiota (GM), but differences in this feature may alter various parameters in animal models. We hypothesized that variation in the GM correlated with variation in clinical parameters of a murine oxazolone-induced skin inflammati... | ['Animals', 'Cecum', 'Cytokines', 'Denaturing Gradient Gel Electrophoresis', 'Dermatitis, Atopic', 'Ear', 'Feces', 'Female', 'Gastrointestinal Tract', 'Metagenome', 'Mice', 'Mice, Inbred BALB C', 'Oxazolone', 'Principal Component Analysis', 'Regression Analysis', 'Water Loss, Insensible'] | 23,114,040 | [['B01.050'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E05.196.401.402.117', 'E05.301.300.319.201'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['A01.456.313', 'A09.246'], ['A12.459'], ['A03.556'], ['G0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation. | Dendritic cells (DCs) are considered to be the most efficient antigen-presenting cells. Intratracheal administration of allergen-pulsed bone marrow-derived dendritic cells (BMDCs) before allergen challenge induces airway hyperresponsiveness (AHR) and inflammation. Ovalbumin (OVA)-pulsed BMDCs from wild-type (WT) mice w... | ['Animals', 'Bronchial Hyperreactivity', 'Bronchoalveolar Lavage Fluid', 'CD4 Antigens', 'CD4-Positive T-Lymphocytes', 'CD8 Antigens', 'CD8-Positive T-Lymphocytes', 'Cytokines', 'Dendritic Cells', 'Female', 'Goblet Cells', 'Inflammation', 'Interleukin-13', 'Lymphocyte Activation', 'Lymphocyte Subsets', 'Mice', 'Mice, I... | 19,151,321 | [['B01.050'], ['C08.127.210'], ['E05.927.100.500'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D23.050.301.264.894.108', 'D23.101.100.894.10... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impaired response of human pancreatic polypeptide to insulin-induced hypoglycemia in chronic pancreatitis without diabetes mellitus. | In order to clarify the pancreatic endocrine functions in mild chronic pancreatitis, the response of insulin to oral glucose load and the response of glucagon and human pancreatic polypeptide (HPP) to insulin-induced hypoglycemia were investigated in five normal controls and eight patients with chronic pancreatitis but... | ['Adult', 'Aged', 'Blood Glucose', 'Chronic Disease', 'Female', 'Glucagon', 'Glucose', 'Humans', 'Hypoglycemia', 'Insulin', 'Male', 'Middle Aged', 'Pancreatic Polypeptide', 'Pancreatitis', 'Radioimmunoassay'] | 6,763,560 | [['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C23.550.291.500'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['M01.060.116.63... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stent implantation in an adult with coarctation of the aorta in the presence of advanced secondary heart failure. | We report the case of a 56-year-old woman with congenital coarctation of the aorta, who presented in critical clinical condition with advanced secondary cardiomyopathy and heart failure. We successfully applied an unusual technique to pass the aortic obstruction, and then implanted a PALMAZ stent. The procedure resulte... | ['Aortic Coarctation', 'Cardiac Catheterization', 'Catheterization', 'Coronary Angiography', 'Female', 'Heart Failure', 'Humans', 'Middle Aged', 'Stents'] | 10,397,440 | [['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E02.148', 'E05.157'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Thickness-dependent crystallization on thermal anneal for titania/silica nm-layer composites deposited by ion beam sputter method. | Crystallization following thermal annealing of thin film stacks consisting of alternating nm-thick titania/silica layers was investigated. Several prototypes were designed, featuring a different number of titania/silica layer pairs, and different thicknesses (in the range from 4 to 40 nm, for the titania layers), but t... | ['Crystallization', 'Nanostructures', 'Silicon Dioxide', 'Temperature', 'Titanium', 'X-Ray Diffraction'] | 25,606,914 | [['E05.196.300', 'G02.171'], ['J01.637.512'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Evaluation of mitochondrial DNA coding region assays for increased discrimination in forensic analysis. | There is an increasing trend to use mitochondrial DNA (mtDNA) analysis in criminal investigations where only limited amounts of DNA are available. However, analysis of the mtDNA control region has the drawback of low discrimination power, due to the lack of recombination that results from uniparental (maternal) inherit... | ['DNA, Mitochondrial', 'Databases, Genetic', 'European Continental Ancestry Group', 'Forensic Medicine', 'Genetic Variation', 'Haplotypes', 'Humans', 'Polymorphism, Single Nucleotide', 'Sequence Analysis, DNA', 'Sweden'] | 19,083,783 | [['D13.444.308.283.225'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['M01.686.508.400'], ['H02.403.330', 'I01.198.780.937'], ['G05.365'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['E05.393.760.700'], ['Z01.542.816.500']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
Craving for cocaine in addicted users. Role of serotonergic mechanisms. | Very few studies have examined the role of serotonin (5-HT) in the modulation of craving for cocaine in cocaine-addicted persons. The authors evaluated whether the acute increase in serotonergic neurotransmission after the administration of a challenging dose of the 5-HT partial agonist meta-chlorophenylpiperazine (m-C... | ['Administration, Oral', 'Adult', 'Cocaine', 'Humans', 'Male', 'Piperazines', 'Serotonin', 'Serotonin Receptor Agonists', 'Substance-Related Disorders', 'Synaptic Transmission'] | 9,097,873 | [['E02.319.267.100'], ['M01.060.116'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.606'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650'], ['D27.505.519.625.850.800', 'D27.505.696.577.850.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regression of left hyperschematia after prism adaptation: A single case study. | Prism adaptation (PA) is a promising treatment in the rehabilitation of post-stroke cognitive disorders such as unilateral spatial neglect or constructional deficits. Right brain damage can bring about another representational spatial disorder, termed «hyperschematia», and defined by a left-sided disproportionate expan... | ['Adaptation, Physiological', 'Attention', 'Cerebral Cortex', 'Female', 'Functional Laterality', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Nerve Net', 'Orientation', 'Perceptual Disorders', 'Space Perception'] | 31,125,738 | [['G07.025', 'G16.012.500'], ['F02.830.104.214'], ['A08.186.211.200.885.287.500'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A08.511'], ['F01.058.577', 'F02.830.606'], ['C10.597.606.762', 'C23.888.592.604.764', 'F01.700.750']... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Seasonal variation in the occurrence of venous thromboembolism: a report from the Korean Venous Thromboembolism Working Party. | There have been conflicting results on seasonal variation in the occurrence of venous thromboembolism (VTE). It also has never been studied in Asian population. To address these issues, we investigated seasonal changes of the incidence of VTE in Korean population using 1,495 patients with VTE between January 2001 and D... | ['Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Republic of Korea', 'Risk Factors', 'Seasons', 'Veins', 'Venous Thromboembolism'] | 22,901,545 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['Z01.252.474.557.750'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Altered motion repulsion in Alzheimer's disease. | Recent research in Alzheimer's disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the properties of direction re... | ['Adolescent', 'Adult', 'Aged', 'Alzheimer Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motion Perception', 'Visual Cortex', 'Visual Perception', 'Young Adult'] | 28,106,153 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593.932.567'], ['A08.186.211.200.885.287.500.571.735', 'A08.186.211.200.885.287.500.814.953'], ['F02.463.593.932'], ['M01... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of disease awareness on lifestyle changes and the use of preventive measures in asthma patients. | Reduction in asthma incidences and mortality, as well as improved quality of life, can be achieved via a wide use of prevention methods. A number of randomized cohort studies demonstrated the effectiveness of such management and the need for multiple treatments. Here, we evaluate whether asthma awareness influences the... | ['Adolescent', 'Adult', 'Allergens', 'Animals', 'Asthma', 'Child', 'Environmental Exposure', 'European Union', 'Female', 'Humans', 'Incidence', 'Male', 'Patient Education as Topic', 'Randomized Controlled Trials as Topic', 'Risk Reduction Behavior', 'Sex Factors', 'Socioeconomic Factors', 'Young Adult'] | 25,715,234 | [['M01.060.057'], ['M01.060.116'], ['D23.050.063'], ['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['N06.850.460.350'], ['I01.615.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Mental stress-induced increase in blood pressure is not related to baroreflex sensitivity in middle-aged healthy men. | The baroreflex that acts to blunt blood pressure (BP) variations through opposite variations in heart rate should limit the BP increase produced by an emotional challenge. However, relations between baroreflex sensitivity and BP reactivity induced by a psychological stress in a large group of adults have never been fir... | ['Adolescent', 'Adult', 'Age Factors', 'Baroreflex', 'Blood Pressure', 'Cohort Studies', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Stress, Psychological', 'Sympathetic Nervous System'] | 10,775,556 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G09.330.380.057', 'G11.561.731.063'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction. | The INK4a proteins p16(INK4a) and p19(ARF) regulate cell cycle arrest and senescence. However, the role of these proteins in controlling these processes in the normal kidney and following injury is unknown. We performed unilateral ureteral obstruction (UUO) to induce fibrosis in 2- to 3-mo-old wild-type (WT) C57/B6 and... | ['Animals', 'Apoptosis', 'Cell Proliferation', 'Cellular Senescence', 'Cyclin-Dependent Kinase Inhibitor p16', 'Fibrosis', 'Kidney', 'Male', 'Mice', 'Mice, Knockout', 'Ureteral Obstruction'] | 20,861,074 | [['B01.050'], ['G04.146.954.035'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.043'], ['D12.644.360.225.200', 'D12.776.167.187.200', 'D12.776.476.225.200', 'D12.776.624.776.355.200'], ['C23.550.355'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.99... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. | Small ubiquitin-like modifier (SUMO) proteins are covalently attached to target proteins to modify their function. SUMO conjugation participates in processes tightly linked to tumorigenesis. Recently USPL1 (ubiquitin-specific peptidase-like (1) was identified as a SUMO isopeptidase. We report here on the first explorat... | ['Alleles', 'Body Mass Index', 'Breast Neoplasms', 'Case-Control Studies', 'Cell Line, Tumor', 'Databases, Genetic', 'Endopeptidases', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genetic Predisposition to Disease', 'Genotype', 'Homozygote', 'Humans', 'Polymorphism, Single Nucleotide', 'Quantitative Trait Loci'... | 23,338,788 | [['G05.360.340.024.340.030'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210.190', 'A11.251.860.180'], ['L01.313.500.750.300.188.400.325', 'L01.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Childhood deafness in Cape Town. | An aetiological survey of a Cape Peninsula school for the deaf, in which 366 Cape Coloured and Asiatic children were examined, is reported. The relevant hereditary factors and the abnormal clinical findings are documented, and the more important of these are discussed. In 20% (74) of the children, the deafness was gene... | ['Abducens Nerve', 'Abnormalities, Multiple', 'Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Deafness', 'Eye Diseases', 'Facial Paralysis', 'Female', 'Genes, Dominant', 'Genes, Recessive', 'Humans', 'Male', 'Nails, Malformed', 'Nervous System Diseases', 'Pulmonary Valve Stenosis', 'Retinitis Pigmentosa', 'Sex Chr... | 1,154,167 | [['A08.800.800.120.030'], ['C16.131.077'], ['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['C11'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.... | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
[Short account of the history of thyroid surgery]. | Historical writings have described abnormalities of the thyroid gland for more than 3500 years. The relationship between the thyroid gland and goiter has been unknown until the XX century. Originally, what we know today as goiter was described as bronchocele. It was Wharton who in 1656 named the gland "thyroid", not be... | ['Europe', 'Goiter', 'History, 15th Century', 'History, 16th Century', 'History, 17th Century', 'History, 18th Century', 'History, 19th Century', 'History, 20th Century', 'History, Ancient', 'History, Medieval', 'Humans', 'Thyroidectomy'] | 16,035,664 | [['Z01.542'], ['C19.874.283'], ['K01.400.475.500'], ['K01.400.475.750'], ['K01.400.504.750'], ['K01.400.504.875'], ['K01.400.504.937'], ['K01.400.504.968'], ['K01.400.470'], ['K01.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.270.856']] | ['Geographicals [Z]', 'Diseases [C]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study. | OBJECTIVES/HYPOTHESIS: Predicting the prognosis of idiopathic sudden sensorineural hearing loss (ISSHL) remains challenging. This investigation aimed to apply Framingham Risk Scores (FRS) to assess the combination of prognostic factors following ISSHL and investigate the predictive role of FRS in patients with multiple... | ['Administration, Oral', 'Adult', 'Audiometry, Pure-Tone', 'Comorbidity', 'Female', 'Glucocorticoids', 'Hearing Loss, Sensorineural', 'Hearing Loss, Sudden', 'Humans', 'Male', 'Methylprednisolone', 'Middle Aged', 'Prognosis', 'Republic of Korea', 'Risk Assessment', 'Treatment Outcome'] | 28,397,567 | [['E02.319.267.100'], ['M01.060.116'], ['E01.370.382.375.060.055'], ['N05.715.350.225', 'N06.850.490.687'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['C09.218.458.341.900', 'C10.597.751.418.341.900', 'C23.888.592.763.393.341.900']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Extending the viability of sea urchin gametes. | The sea urchin is the material of choice for studying many early developmental events. Methods to extend the viability of sea urchin gametes have not received much attention, but it is well known that the eggs are easily damaged by freezing. This study was designed to extend the viability of Lytechinus pictus eggs and ... | ['Animals', 'Cell Survival', 'Cryopreservation', 'Evaluation Studies as Topic', 'Female', 'Fertilization in Vitro', 'In Vitro Techniques', 'Male', 'Ovum', 'Sea Urchins', 'Spermatozoa', 'Time Factors'] | 7,743,818 | [['B01.050'], ['G04.346'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E05.337', 'N05.715.360.335'], ['E02.875.800.750', 'E05.820.800.750'], ['E05.481'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['B01.050.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. | Cu and Zn have been shown to accumulate in the brains of Alzheimer's disease patients. We have previously reported that Cu(2+) and Zn(2+) bind amyloid beta (Abeta), explaining their enrichment in plaque pathology. Here we detail the stoichiometries and binding affinities of multiple cooperative Cu(2+)-binding sites on ... | ['Amyloid beta-Peptides', 'Animals', 'Binding Sites', 'Chelating Agents', 'Copper', 'Dogs', 'Humans', 'Kinetics', 'Peptide Fragments', 'Regression Analysis', 'Serum Albumin', 'Zinc'] | 10,936,205 | [['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['G02.111.570.120'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Volatile and biogenic amines, microbiological counts, and bacterial amino acid decarboxylase activity throughout the salt-ripening process of anchovies (Engraulis encrasicholus). | Chemical and microbiological parameters were studied during the industrial production of salt-ripened anchovies (Engraulis encrasicholus). Gradual acidification and increases in the proteolysis index and in total volatile basic nitrogen were observed. At the end of the maturing process, the values reached pH 5.55 +/- 0... | ['Animals', 'Biogenic Amines', 'Carboxy-Lyases', 'Colony Count, Microbial', 'Consumer Product Safety', 'Enterobacteriaceae', 'Enterococcus', 'Food Contamination', 'Food Microbiology', 'Humans', 'Salts', 'Seafood', 'Volatilization'] | 21,132,979 | [['B01.050'], ['D02.092.211'], ['D08.811.520.224.125'], ['E01.370.225.875.220', 'E05.200.875.220'], ['N06.850.210'], ['B03.440.450.425', 'B03.660.250.150'], ['B03.353.750.250.250', 'B03.510.550.250.250'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['H01.158.273.540.274.332', 'J01.576.423... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Antagonism by d,1-propranolol of imipramine effects in mice. | Three agents with known or suspected antidepressant activity, imipramine, salbutamol and dexamphetamine, were active in animal tests predictive of an antidepressant effect in man: antagonism of the hypothermia induced by reserpine, by oxotremorine or by a high dose of apomorphine, and the potentiation of the yohimbine-... | ['Albuterol', 'Animals', 'Apomorphine', 'Body Temperature', 'Dextroamphetamine', 'Drug Interactions', 'Imipramine', 'Male', 'Mice', 'Oxotremorine', 'Propranolol', 'Reserpine', 'Yohimbine'] | 520,412 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The intrapancreatic anatomy as an index of adequacy of pancreatic arteriography. | Analysis of 100 pancreatic arteriograms in respect of intrapancreatic arteries shown has been performed. The results have been compared with Michels' classic series of 200 cadaveric dissections. Excellent correlation has been found. The degree of demonstration of small intrapancreatic arteries in our view is an index o... | ['Angiography', 'Humans', 'Pancreas', 'Pancreatic Neoplasms', 'Prognosis'] | 589,913 | [['E01.370.350.700.060', 'E01.370.370.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.734'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E01.789']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and Validation of a Prediction Model for Pain and Functional Outcomes After Lumbar Spine Surgery. | Importance: Functional impairment and pain are common indications for the initiation of lumbar spine surgery, but information about expected improvement in these patient-reported outcome (PRO) domains is not readily available to most patients and clinicians considering this type of surgery.Objective: To assess populati... | ['Cohort Studies', 'Female', 'Forecasting', 'Humans', 'Leg', 'Low Back Pain', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Models, Theoretical', 'Pain', 'Patient Reported Outcome Measures', 'Recovery of Function', 'Spinal Fusion', 'Treatment Outcome'] | 29,516,096 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['C23.888.592.612.107.400'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['E05.599'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E05.318.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Evolving Alignment in International Continuing Professional Development Accreditation. | Several of the world's accreditation systems for continuing professional development (CPD) are evolving to encourage continuous improvement in the competence and performance of health care providers and in the organizations in which they provide patient care. Clinicians learn best when they can to choose from a diverse... | ['Accreditation', 'Attitude of Health Personnel', 'Education, Continuing', 'Health Personnel', 'Humans', 'Internationality', 'Staff Development', 'Workforce'] | 27,584,065 | [['N03.706.110.070', 'N05.700.200.100'], ['F01.100.050', 'N05.300.100'], ['I02.358.212'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615'], ['I02.574.700', 'N04.452.677.822'], ['N04.452.525']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Structural characterization of Saccharomyces cerevisiae prion-like protein Ure2. | Sacchromyces cerevisiae prion-like protein Ure2 was expressed in Escherichia coli and was purified to homogeneity. We show here that Ure2p is a soluble protein that can assemble into fibers that are similar to the fibers observed in the case of PrP in its scrapie prion filaments form or that form on Sup35 self-assembly... | ['Base Sequence', 'Biopolymers', 'Cloning, Molecular', 'DNA Primers', 'Escherichia coli', 'Fungal Proteins', 'Glutathione Peroxidase', 'Microscopy, Electron', 'Molecular Weight', 'Prions', 'Protein Conformation', 'Recombinant Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Solubility'] | 10,224,139 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.354'], ['D08.811.682.732.500'], ['E01.370.350.515.402', 'E05.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Serum PLR and LMR in Beh?et's disease: Can they show the disease activity? | The aim of this study is to determine platelet to lymphocyte ratio (PLR) and lymphocytes to monocytes ratio (LMR) levels in Beh?et's disease (BD) and to investigate their relationships with disease activity.Hematological and inflammatory parameters including high-sensitivity C-reactive proteins (hs-CRP), erythrocyte se... | ['Adult', 'Behcet Syndrome', 'Biomarkers', 'Blood Platelets', 'Female', 'Humans', 'Logistic Models', 'Lymphocytes', 'Male', 'ROC Curve', 'Retrospective Studies', 'Severity of Illness Index'] | 28,538,403 | [['M01.060.116'], ['C07.465.075', 'C11.941.879.780.880.200', 'C14.907.940.100', 'C16.320.382.250', 'C17.800.827.368.250', 'C17.800.862.150'], ['D23.101'], ['A11.118.188', 'A15.145.229.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.5... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Community-based persons with mental retardation: opportunities for health promotion. | The public policy of supporting the mentally retarded in community-based, group home environments provides an exciting opportunity for nurses to develop health promotion and self-care programs to increase the independent living capacity of this population. This article discusses the issues raised and solutions develope... | ['Activities of Daily Living', 'Adult', 'Aged', 'Aging', 'Caregivers', 'Communication', 'Community Mental Health Services', 'Female', 'Group Processes', 'Health Promotion', 'Humans', 'Intellectual Disability', 'Male', 'Middle Aged', 'Nurse Practitioners', 'Self Care', "Women's Health"] | 9,325,894 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F01.145.209', 'L01.143'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['F01.829.316'], ['I02.233.332.445', 'N02.421.726.407.579'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. | Role of carbon monoxide (CO) in hyperthermic brain injury induced brain pathology was examined in a rat model using immunohistochemistry of the hemeoxygenase-2 (HO-2) enzyme. Exposure of rats to 4 h heat stress at 38 degrees C resulted in profound hyperthermia, breakdown of the blood-brain barrier (BBB), brain edema fo... | ['Animals', 'Antioxidants', 'Blood-Brain Barrier', 'Brain Edema', 'Brain Injuries', 'Capillary Permeability', 'Diterpenes', 'Fever', 'Ginkgo biloba', 'Ginkgolides', 'Heme Oxygenase (Decyclizing)', 'Hot Temperature', 'Lactones', 'Male', 'Plant Extracts', 'Rats', 'Rats, Sprague-Dawley', 'Stress, Physiological'] | 14,753,460 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A07.035', 'A08.186.211.035'], ['C10.228.140.187'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['G03.143.330', 'G09.330.165'], ['D02.455.849.291'], ['C23.888.119.344'], ['B01.650.940.800.575.912.125'], ['D02.455.849.291.400'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Buserelin as primary therapy in advanced prostatic carcinoma. | The effectiveness of buserelin, a luteinizing hormone-releasing hormone agonist, was tested in 28 patients with Stages C or D adenocarcinoma of the prostate. Of 24 evaluable patients, there were 13 partial responses (54%) by National Prostatic Cancer Project criteria, median duration greater than 6 months. Nine patient... | ['Adult', 'Aged', 'Buserelin', 'Castration', 'Diethylstilbestrol', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Prostatic Neoplasms', 'Quality of Life', 'Testosterone'] | 3,930,064 | [['M01.060.116'], ['M01.060.116.100'], ['D06.472.699.327.740.320.100', 'D12.644.400.400.740.320.100', 'D12.644.456.460.150', 'D12.644.548.365.740.320.100', 'D12.776.631.650.405.740.320.100'], ['E04.270.282', 'E04.950.165'], ['D02.455.426.559.389.150.700.725.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Fluoxetine for migraine prophylaxis: a double-blind trial. | UNLABELLED: Selective serotonin reuptake inhibitors have recently been used in the treatment of migraine.OBJECTIVE: We studied the safety and efficacy of fluoxetine in the prevention of migraine.PATIENTS: Between February 1997 and December 1997, we examined 52 patients (33 women) at the Headache Diagnosis and Therapy S... | ['Adult', 'Double-Blind Method', 'Female', 'Fluoxetine', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Preventive Medicine', 'Serotonin Uptake Inhibitors'] | 11,279,947 | [['M01.060.116'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.092.831.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.546.399.750'], ['H02.403.720.750'], ['D27.505.519.562.437.850', 'D27.505.519.625.600.850', 'D27.505.519.625.850... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibitory action of extracts of Maclura aurantiaca and Epilobium hirsutum on tumour models in mice. | Primary screening of alcohol extracts of fruits of Maclura aurantiaca (Moraceae) and the overground part of Epilobium hirsutum (Onagraceae) was conducted in order to test the anti-tumour action on models in mice. Applied in doses of 100 mg/kg and 90 mg/kg, Maclura extract increased the life span of the mice by 158 and ... | ['Animals', 'Antineoplastic Agents, Phytogenic', 'Carcinoma, Ehrlich Tumor', 'Female', 'Leukemia P388', 'Male', 'Mice', 'Plant Extracts', 'Plants, Medicinal'] | 1,841,518 | [['B01.050'], ['D27.505.954.248.179'], ['C04.557.470.200.200', 'C04.619.169'], ['C04.557.337.372.782', 'C04.619.531.782'], ['B01.050.150.900.649.313.992.635.505.500'], ['D20.215.784.500', 'D26.667'], ['B01.650.560']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of and risk factors for suicide-related outcomes in the World Health Organization World Mental Health Surveys Japan. | AIM: Suicide is a major public health concern in Japan but little is known about the prevalence of and risk factors for suicidal ideation, plans, and attempts. The aim of the present study was to clarify the prevalence of and risk factors for important suicide-related outcomes.METHODS: Important suicide-related outcome... | ['Adult', 'Age Factors', 'Aged', 'Anxiety Disorders', 'Cohort Studies', 'Comorbidity', 'Cross-Sectional Studies', 'Female', 'Health Surveys', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Mood Disorders', 'Risk Factors', 'Rural Population', 'Suicide, Attempted', 'Urban Population', 'World Health Organization', 'Young Adul... | 18,778,442 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F03.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438', 'N05.7... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gesture production and comprehension in children with specific language impairment. | Children with specific language impairment (SLI) have difficulties with spoken language. However, some recent research suggests that these impairments reflect underlying cognitive limitations. Studying gesture may inform us clinically and theoretically about the nature of the association between language and cognition.... | ['Child', 'Child Behavior', 'Child, Preschool', 'Cognition', 'Comprehension', 'Cues', 'Female', 'Gestures', 'Humans', 'Language Development Disorders', 'Male', 'Reading', 'Semantics', 'Speech', 'Task Performance and Analysis', 'Verbal Behavior', 'Vocabulary'] | 20,306,625 | [['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['F02.463.188'], ['F02.463.188.357'], ['F02.463.425.234'], ['F01.145.209.530.538.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.150.500.550', 'C23.888.592.604.150.500.550'], ['L01.559.423.557'], ['L01.559.598.745'], ['F01.145.209.908.677', '... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Food habits of adults in France. Epidemiological data]. | During the year 1990, 43,440 men and women aged from 17 to 69 years accepted to fill the NAQA questionnaire (18 items) on feeding habits, as part of a routine health examination. The frequency of consumptions and the amounts of food consumed are reported here according to sex. Mean energy intake was 2,586 kcal for men ... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Feeding Behavior', 'Female', 'France', 'Humans', 'Male', 'Middle Aged', 'Sex Factors', 'Socioeconomic Factors', 'Surveys and Questionnaires'] | 1,387,949 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N05.715.350.675', 'N06.850.490.875'], ['I01.880.853.996', 'N01.824'], ['E05.318.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Does Suture Technique Affect Re-Rupture in Arthroscopic Rotator Cuff Repair? A Meta-analysis. | PURPOSE: To evaluate the effects of suture configuration, repair method, and tear size on rotator cuff (RC) repair healing.METHODS: We conducted a literature search of articles that examined surgical treatment of RC tears published between January 2003 and September 2014. For single-row (SR) repairs, we calculated reru... | ['Arthroplasty', 'Arthroscopy', 'Humans', 'Lacerations', 'Recurrence', 'Rotator Cuff', 'Rotator Cuff Injuries', 'Rupture', 'Suture Techniques', 'Sutures', 'Wound Healing'] | 25,828,166 | [['E04.555.110', 'E04.680.101'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.540'], ['C23.550.291.937'], ['A02.633.567.912', 'A02.880.700'], ['C26.761.340', 'C26.803.063', 'C26.874.400'], ['C26.761'], ['E04.987.775'], ['E07.858.690.820'], ['G16.762.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury. | Traumatic spinal cord injury (SCI) causes severe and permanent functional deficits due to the primary mechanical insult followed by secondary tissue degeneration. The cascade of secondary degenerative events constitutes a range of therapeutic targets which, if successfully treated, could significantly ameliorate functi... | ['Animals', 'Disease Models, Animal', 'Disease Progression', 'Drug Therapy, Combination', 'Enzyme-Linked Immunosorbent Assay', 'Gene Expression Regulation', 'Immunosuppressive Agents', 'Interleukin-1beta', 'Locomotion', 'Male', 'Myelin Basic Protein', 'Nerve Regeneration', 'Neurofilament Proteins', 'Phosphodiesterase I... | 19,320,007 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['E02.319.310'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.308'], ['D27.505.696.477.656'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D1... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition in fat-storing cell multiplication by a factor produced by normal cultured murine hepatocytes. | In this study we demonstrate that hepatocytes isolated from normal mice may efficiently inhibit the multiplication of fat-storing cells (FSC) in culture, either in a coculture system where both cell types are separated by a filter of 0.45 microns pore size or via their conditioned medium. The inhibition may be complete... | ['Animals', 'Cell Communication', 'Cell Division', 'Cell Separation', 'Cells, Cultured', 'Endothelium', 'Kupffer Cells', 'Liver', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Proteins', 'Rats', 'Rats, Inbred Strains'] | 2,290,024 | [['B01.050'], ['G04.085'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['A10.272.491'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['B01.050.15... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Minimum effective release rate of antifoulants. 2. Effects of TBTCI, 2-furyl-n-pentyl ketone and coumaric acid at Snug harbor, Hawaii. | Minimum effective release rate (MERR) of three antifoulants was examined at Snug harbor, Hawaii using a dynamic diffusion system. Among the three antifoulants tested TBTCI was found to be effective in preventing the settlement of Hydroides elegans and Crisea sp at 0.5 microg cm(-2) d(-1) flux rate. At a maximum flux ra... | ['Animals', 'Coumaric Acids', 'Invertebrates', 'Ketones', 'Larva', 'Manufactured Materials', 'Pest Control', 'Ships', 'Trialkyltin Compounds'] | 12,617,321 | [['B01.050'], ['D02.241.223.200.210'], ['B01.050.500'], ['D02.522'], ['B05.500.500', 'G07.345.500.550.500.500'], ['J01.637'], ['N06.850.780.200.650'], ['J01.937.817'], ['D02.691.850.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Increased susceptibility to proactive interference in adults with dyslexia? | Recent findings show that people with dyslexia have an impairment in serial-order memory. Based on these findings, the present study aimed to test the hypothesis that people with dyslexia have difficulties dealing with proactive interference (PI) in recognition memory. A group of 25 adults with dyslexia and a group of ... | ['Case-Control Studies', 'Dyslexia', 'Humans', 'Memory, Short-Term', 'Proactive Inhibition', 'Recognition, Psychology', 'Young Adult'] | 24,521,515 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C10.597.606.150.500.300', 'C10.597.606.150.550.200', 'C23.888.592.604.150.500.300', 'C23.888.592.604.150.550.200', 'F03.625.562.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['F01.145.544.538', 'F02.463.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Single-molecule dissection of the high-affinity cohesin-dockerin complex. | Cellulose-degrading enzyme systems are of significant interest from both a scientific and technological perspective due to the diversity of cellulase families, their unique assembly and substrate binding mechanisms, and their potential applications in several key industrial sectors, notably cellulose hydrolysis for sec... | ['Amino Acid Substitution', 'Bacterial Proteins', 'Biophysics', 'Calcium', 'Cell Cycle Proteins', 'Chromosomal Proteins, Non-Histone', 'Clostridium thermocellum', 'Crystallography, X-Ray', 'Hydrogen Bonding', 'Microscopy, Atomic Force', 'Models, Molecular', 'Multiprotein Complexes', 'Mutagenesis, Site-Directed', 'Prote... | 23,188,794 | [['E05.393.420.601.035', 'G05.558.109'], ['D12.776.097'], ['H01.158.344', 'H01.671.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.167'], ['D12.776.660.235', 'D12.776.664.235'], ['B03.300.390.400.200.770', 'B03.353.625.375.500.770', 'B03.510.415.400.200.770'], ['E05.196.309.742.225'], ['G02.282'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative electrophysiological and hemodynamic measures of neural activation during memory-retrieval. | The spatial and temporal characteristics of the brain processes underlying memory retrieval were studied with both event-related potentials (ERP) and positron emission tomography (PET) techniques. Subjects studied lists of 20 words and then performed episodic (old/new judgment) or semantic (living/nonliving decision) r... | ['Adult', 'Brain Mapping', 'Cerebral Cortex', 'Cerebrovascular Circulation', 'Evoked Potentials', 'Female', 'Functional Laterality', 'Hemodynamics', 'Humans', 'Male', 'Memory', 'Neurons', 'Neuropsychological Tests', 'Psychomotor Performance', 'Tomography, Emission-Computed', 'Verbal Behavior'] | 11,346,889 | [['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['G09.330.100.159'], ['G07.265.216.500', 'G11.561.200.500'], ['F02.830.297.425', 'G11.561.225.425'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['A08.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of continuous insulin infusion therapy on lipoprotein surface and core lipid composition in insulin-dependent diabetes mellitus. | To determine whether intensive insulin therapy has the same beneficial effects on lipoprotein composition that it has been shown to have in insulin-dependent diabetes mellitus (IDDM) on the routinely measured plasma lipids, we studied 10 patients after 6 months of conventional therapy (CIT) and again after 6 months of ... | ['Adult', 'Cholesterol', 'Cholesterol, HDL', 'Diabetes Mellitus, Type 1', 'Female', 'Humans', 'Injections', 'Insulin', 'Insulin Infusion Systems', 'Lipids', 'Lipoproteins', 'Male', 'Osmolar Concentration', 'Phosphatidylcholines', 'Phospholipids'] | 2,023,530 | [['M01.060.116'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['D0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of ritanserin on the rewarding properties of d-amphetamine, morphine and diazepam revealed by conditioned place preference in rats. | The possibility that 5-HT2 receptors mediate the reinforcing properties of d-amphetamine, morphine and diazepam was investigated in rats, using ritanserin, a 5-HT2 antagonist, and the conditioned place preference paradigm. Ritanserin 1 or 2.5 mg/kg did not cause place conditioning. Place preference induced by 1.5 mg/kg... | ['Analgesia', 'Animals', 'Conditioning, Operant', 'Dextroamphetamine', 'Diazepam', 'Exploratory Behavior', 'Male', 'Morphine', 'Motor Activity', 'Piperidines', 'Rats', 'Rats, Inbred Strains', 'Reference Values', 'Reinforcement, Psychology', 'Reward', 'Ritanserin', 'Serotonin Antagonists'] | 3,147,460 | [['E03.091'], ['B01.050'], ['F02.463.425.179.509'], ['D02.092.471.683.152.110.200'], ['D03.633.100.079.080.070.216'], ['F01.145.387', 'F01.658.370'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['F01.145.632', 'G11.427.410.698'], ['D03.383.621'], ['B01.050.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Models of tibial fracture healing in normal and Nf1-deficient mice. | Delayed union and nonunion are common complications associated with tibial fractures, particularly in the distal tibia. Existing mouse tibial fracture models are typically closed and middiaphyseal, and thus poorly recapitulate the prevailing conditions following surgery on a human open distal tibial fracture. This repo... | ['Animals', 'Bone Density', 'Bony Callus', 'Cartilage', 'Disease Models, Animal', 'Fracture Healing', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Neurofibromin 1', 'Periosteum', 'Pseudarthrosis', 'Radiography', 'Tibial Fractures'] | 18,383,150 | [['B01.050'], ['G11.427.100'], ['A10.165.265.200'], ['A02.165', 'A10.165.382'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G16.762.891.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', 'B01.050.150.90... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antioxidant properties and chemical characterization of Spanish Opuntia ficus-indica Mill. cladodes and fruits. | BACKGROUND: Recent studies have demonstrated that consumption of Opuntia ficus-indica Mill. has an important positive health benefit, mainly due to antioxidant properties, which justifies this research. This study examined antioxidant activity, organic acid and sugar profile, total phenolic, and physicochemical charact... | ['Antioxidants', 'Chromatography, High Pressure Liquid', 'Flavonoids', 'Fruit', 'Opuntia', 'Phenols', 'Plant Extracts', 'Spain'] | 28,833,143 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.196.181.400.300'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.198.500.200.500'], ['D02.455.426.559.389.657'], ['D20.215.784.500', 'D26.667'], ['Z01.542.846'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits. | OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles.MATERIAL AND METHODS: Sandblasted and cleansed planar titanium specimens with a size of 5 ? 5 ? 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The ot... | ['Animals', 'Bone Regeneration', 'Coated Materials, Biocompatible', 'Cone-Beam Computed Tomography', 'Dental Implantation, Endosseous', 'Dental Implants', 'Eicosapentaenoic Acid', 'Implants, Experimental', 'Mandible', 'Rabbits', 'Random Allocation', 'Surface Properties', 'Titanium'] | 25,393,376 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['D25.130.420', 'J01.637.051.130.420'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Robust misinterpretation of confidence intervals. | Null hypothesis significance testing (NHST) is undoubtedly the most common inferential technique used to justify claims in the social sciences. However, even staunch defenders of NHST agree that its outcomes are often misinterpreted. Confidence intervals (CIs) have frequently been proposed as a more useful alternative ... | ['Behavioral Research', 'Confidence Intervals', 'Data Interpretation, Statistical', 'Educational Status', 'Humans', 'Probability', 'Psychology', 'Students', 'Surveys and Questionnaires'] | 24,420,726 | [['F04.096.144', 'H01.770.644.108'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600', 'G17.680', 'N05.715.3... | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles. | A biologically relevant relationship exists between neutrophils and coagulation processes. Several studies have focused on the ability of neutrophil proteases (both intracellular and membrane-associated) to degrade fibrinogen. The present study investigates the events following the interaction of activated neutrophils ... | ['Electrophoresis, Polyacrylamide Gel', 'Endocytosis', 'Fibrinogen', 'Humans', 'Hydrolysis', 'Microscopy, Electron', 'Neutrophils', 'Tetradecanoylphorbol Acetate', 'Up-Regulation'] | 12,023,883 | [['E05.196.401.402', 'E05.301.300.319'], ['G04.417'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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