Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country. | AIM: To investigate peg-interferon (peg-IFN) and ribavirin (RBV) therapy in Myanmar and to predict sustained virologic response (SVR).METHODS: This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN... | ['Adolescent', 'Adult', 'Aged', 'Antiviral Agents', 'Child', 'Cost-Benefit Analysis', 'Developing Countries', 'Drug Costs', 'Drug Therapy, Combination', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Interferon-alpha', 'Male', 'Middle Aged', 'Myanmar', 'Polyethylene Glycols', 'RNA, Viral', 'Recombinant ... | 27,920,482 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['M01.060.406'], ['N03.219.151.125'], ['I01.615.500.300'], ['N03.219.151.400.350', 'N05.300.375.300'], ['E02.319.310'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Technology, Industry, and Agric... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[The functional prognosis of physical working ability under conditions of extreme high altitude]. | The physical performance of climbers, those making high-altitude ascensions up to 8000 m, without additional oxygen was measured. Some functional criteria of the organism adaptation to exhausting physical loading at the high altitudes were selected. It was established that the forecasting of a successful ascension coul... | ['Adaptation, Physiological', 'Adult', 'Altitude', 'Cardiovascular System', 'Heart Rate', 'Humans', 'Maximal Voluntary Ventilation', 'Mountaineering', 'Physical Exertion', 'Young Adult'] | 21,675,208 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['G16.500.275.058', 'N06.230.058'], ['A07'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.386.700.660.500', 'G09.772.650.630'], ['I03.450.642.845.582'], ['G11.427.683'], ['M01.060.116.815']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Trust in direct leaders and top leaders: A trickle-up model. | Low levels of employee trust in top leaders pose challenges to organizations with respect to retention, performance, and profits. This research examines how trust in top leaders can be fostered through the relationships individuals have with their direct leaders. We propose a trickle-up model whereby trust in direct le... | ['Adult', 'Employment', 'Humans', 'Leadership', 'Organizational Culture', 'Trust', 'Work Performance'] | 28,054,820 | [['M01.060.116'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['N04.452.606'], ['F01.829.401.825'], ['I03.946.675']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of the mature vWF polypeptide. | vWF is a multimeric glycoprotein that serves as the major carrier in plasma of Factor VIII (FVIII). We have used an anti-human vWF MAb W5-6A to investigate the FVIII binding site on vWF. W5-6A inhibited FVIII binding to vWF-coated polystyrene tubes in a concentration-dependent manner with 90% inhibition of FVIII bindin... | ['Antibodies, Monoclonal', 'Bacteriophage lambda', 'Binding, Competitive', 'Blotting, Western', 'DNA, Viral', 'Electrophoresis, Polyacrylamide Gel', 'Epitopes', 'Escherichia coli', 'Factor VIII', 'Genetic Vectors', 'Humans', 'Peptides', 'von Willebrand Factor'] | 2,472,430 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical-angiographic correlations in 132 patients with megadolichovertebrobasilar anomaly. | We have found numerous case reports, but no systematic study of the megadolichovertebrobasilar anomaly ( MDVBA ). The purpose of this paper is to evaluate the relationships between arterial shifts of the vertebro-basilar system and neurological findings in the posterior fossa in our series of 132 cases. We found a high... | ['Basilar Artery', 'Cerebellar Diseases', 'Cerebral Angiography', 'Cranial Fossa, Posterior', 'Cranial Nerves', 'Facial Paralysis', 'Humans', 'Hydrocephalus', 'Nerve Compression Syndromes', 'Trigeminal Neuralgia', 'Vertebral Artery'] | 6,738,853 | [['A07.015.114.106'], ['C10.228.140.252'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['A08.800.800.120'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of double zones of hemolysis by certain strains of hemolytic streptococci of groups A, B, C, and G on heart infusion agar. | This report describes the appearance of a double zone of hemolysis around surface colonies of certain strains of streptococci of groups A, B, C, and G incubated aerobically on sheep blood-Heart Infusion Agar. The occurrence of the altered hemolytic pattern was related to peroxide production by the organism. Anaerobic c... | ['Aerobiosis', 'Agar', 'Anaerobiosis', 'Animals', 'Catalase', 'Cattle', 'Erythrocytes', 'Glucose', 'Heart', 'Hemolysis', 'Horses', 'Humans', 'Hydrogen Peroxide', 'Liver', 'Peroxides', 'Rabbits', 'Refrigeration', 'Serotyping', 'Sheep', 'Streptococcus'] | 5,107,005 | [['G02.111.017', 'G03.049'], ['D09.698.360.041'], ['G02.111.062', 'G03.078'], ['B01.050'], ['D08.811.682.732.332'], ['B01.050.150.900.649.313.500.380.271'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D09.947.875.359.448'], ['A07.541'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.984.235.472'], [... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Accuracy and Feasibility of Robotic Assisted Lead Implantation in Nonhuman Primates. | OBJECTIVES: Deep brain stimulation (DBS) and stereo-electroencephalography (SEEG) electrode implantation are the most important and frequent manipulations in nonhuman primates (NHP) neuromodulation research. However, traditional methods tend to be arduous and inaccurate.MATERIALS AND METHODS: Twelve adult male rhesus m... | ['Animals', 'Deep Brain Stimulation', 'Electrodes, Implanted', 'Electroencephalography', 'Feasibility Studies', 'Macaca mulatta', 'Male', 'Prospective Studies', 'Robotic Surgical Procedures'] | 31,012,530 | [['B01.050'], ['E02.331.300', 'E04.190'], ['E07.305.250.319', 'E07.695.202'], ['E01.370.376.300', 'E01.370.405.245'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Potentially curative resection for locoregional recurrence of colorectal cancer. | PURPOSE: Local recurrence after curative surgery for colorectal cancer may be treated by potentially curative surgery, defined as resection of all macroscopic disease. We conducted this retrospective study to show the effectiveness of potentially curative resection for patients with locoregional recurrence (LRR).METHOD... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Colorectal Neoplasms', 'Colorectal Surgery', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Probability', 'Prognosis', 'Reoperation', 'Retrospective Studies', 'Risk Ass... | 15,526,124 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Multistrain outbreak of chancroid in San Francisco, 1989-1991. | Restriction fragment length polymorphism (RFLP) and plasmid analyses were used to evaluate an outbreak of Haemophilus ducreyi in San Francisco. Fifty-four cases of culture-confirmed chancroid occurred between May 1989 and May 1991. Of these, 46 (96%) were in men and 35 (65%) were in blacks; the median age of patients w... | ['Adolescent', 'Adult', 'Aged', 'Chancroid', 'Demography', 'Disease Outbreaks', 'Female', 'Haemophilus ducreyi', 'Humans', 'Male', 'Middle Aged', 'Plasmids', 'Polymorphism, Restriction Fragment Length', 'Retrospective Studies', 'San Francisco'] | 8,098,052 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C01.150.252.400.700.433.308', 'C01.150.252.734.201', 'C01.221.812.281.201', 'C01.778.281.201', 'C12.294.668.281.201', 'C13.351.500.711.281.201'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['N06.850.290'], ['B03.440.450.600.450.125', 'B03.660.250.550.290.125'], ... | ['Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Human keratinocytes express HLA-DR antigens in the tuberculin reaction. | The cellular response in the human skin tuberculin reaction was studied with immunohistochemical double-staining techniques in frozen sections of skin biopsies taken 6 h to 8 days after intradermal PPD injections. Cell infiltrates were observed from day 2 onwards and increased in size up to 4 days. Most of the infiltra... | ['Adult', 'Animals', 'Antibodies, Monoclonal', 'Epidermis', 'Fluorescent Antibody Technique', 'HLA-DR Antigens', 'Histocompatibility Antigens Class II', 'Humans', 'Hypersensitivity, Delayed', 'Immunoenzyme Techniques', 'Rabbits', 'Receptors, Antigen, B-Cell', 'T-Lymphocytes', 'Tuberculin Test'] | 6,367,023 | [['M01.060.116'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A10.272.497', 'A17.815.250'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D12.776.395.550.509.400... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Longitudinal evaluation of salivary cortisol levels in full-term and preterm neonates. | The aim of the present study was to test the practicability of sequential cortisol determinations in saliva of low birth weight neonates and to evaluate the impact of systemic and inhaled glucocorticoid therapy on saliva concentrations of cortisol in preterm neonates with bronchopulmonary dysplasia (BPD). Salivary cort... | ['Administration, Topical', 'Anti-Inflammatory Agents', 'Bronchopulmonary Dysplasia', 'Budesonide', 'Dexamethasone', 'Gestational Age', 'Humans', 'Hydrocortisone', 'Infant', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature', 'Longitudinal Studies', 'Pituitary-Adrenal System', 'Radioimmunoassay', 'Saliv... | 9,973,669 | [['E02.319.267.120'], ['D27.505.954.158'], ['C08.381.520.750.500', 'C16.614.521.125'], ['D04.210.500.745.745.654.105'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.35... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin. | Glutathione (GSH) and GSH-associated metabolism provide the major line of defense for the protection of cells from various forms of toxic stress. GSH also plays a key role in regulating the intracellular redox environment. Thus, maintenance of GSH levels is developing into an important therapeutic objective for the tre... | ['Activating Transcription Factor 4', 'Animals', 'Cell Line, Transformed', 'Flavonoids', 'Glutathione', 'Mice', 'NF-E2-Related Factor 2', 'Oxidative Stress'] | 23,618,921 | [['D12.776.260.108.061.937', 'D12.776.930.127.061.937'], ['B01.050'], ['A11.251.210.172'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D12.644.456.448'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.260.108.737', 'D12.776.930.127.737'], ['G03.673', 'G07.775.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An echo state neural network for QRST cancellation during atrial fibrillation. | A novel method for QRST cancellation during atrial fibrillation (AF) is introduced for use in recordings with two or more leads. The method is based on an echo state neural network which estimates the time-varying, nonlinear transfer function between two leads, one lead with atrial activity and another lead without, fo... | ['Algorithms', 'Atrial Fibrillation', 'Computer Simulation', 'Electrocardiography', 'Humans', 'Models, Cardiovascular', 'Neural Networks, Computer', 'Signal Processing, Computer-Assisted'] | 22,929,362 | [['G17.035', 'L01.224.050'], ['C14.280.067.198', 'C23.550.073.198'], ['L01.224.160'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.161'], ['G17.485', 'L01.224.050.375.605'], ['L01.224.800']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synergistic but not additive effect between ACPA and lithium in the dorsal hippocampal region on spatial learning and memory in rats: Isobolographic analyses. | Lithium and cannabinoids can disrupt learning and memory performance. The goal of the present study is to investigate the additive or synergistic effect of lithium and cannabinoid combination doses on spatial learning and memory in rats by isobolographic analyses. Although several studies have suggested synergistic eff... | ['Animals', 'Arachidonic Acids', 'Cannabinoid Receptor Agonists', 'Cannabinoids', 'Cerebral Cortex', 'Drug Synergism', 'Hippocampus', 'Lithium', 'Male', 'Maze Learning', 'Rats', 'Rats, Wistar', 'Receptors, Cannabinoid', 'Spatial Learning', 'Spatial Memory', 'Temporal Lobe'] | 31,715,133 | [['B01.050'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['D27.505.519.625.085.500', 'D27.505.696.399.472.188.500'], ['D02.455.849.090'], ['A08.186.211.200.885.287.500'], ['G07.690.773.968.477'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Stage M1b prostatic adenocarcinoma: prognostic factors, value of bone scintigraphy]. | Based on a retrospective study of 52 patients with prostatic adenocarcinoma and bone metastases (stage M1b), the authors analysed the following prognostic factors at the time of diagnosis: age, general status, bone pain, haemoglobin, local tumour volume, ureteric repercussions, pre and post-treatment PAP and PSA levels... | ['Adenocarcinoma', 'Aged', 'Aged, 80 and over', 'Bone Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'Prostatic Neoplasms', 'Radionuclide Imaging', 'Retrospective Studies', 'Risk Factors', 'Survival Analysis'] | 7,874,187 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.149', 'C05.116.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['E01.789'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E01.370.350.710', 'E01.370.384.7... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The ultrastructural difference between CD133-positive U251 glioma stem cells and normal U251 glioma cells. | Glioma stem cells (GSC) have higher tumorigenic potential and stronger chemoresistance and radioresistance than normal glioma cells. The mechanisms behind these phenomena have remained elusive. The authors have isolated CD133-positive U251 GSCs from U251 glioma cells and detected the expression of stem cell markers (CD... | ['AC133 Antigen', 'Antigens, CD', 'Cell Line, Tumor', 'Cell Nucleus', 'Endoplasmic Reticulum', 'Glioma', 'Glycoproteins', 'Humans', 'Microscopy, Electron, Transmission', 'Microscopy, Fluorescence', 'Microvilli', 'Neoplastic Stem Cells', 'Peptides', 'Phenotype'] | 23,216,238 | [['D12.776.395.550.007', 'D12.776.543.550.023'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214.190.875.248'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['D09.400.430', 'D12.77... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An integrated probabilistic approach for gene function prediction using multiple sources of high-throughput data. | Characterising gene function is one of the major challenging tasks in the post-genomic era. Various approaches have been developed to integrate multiple sources of high-throughput data to predict gene function. Most of those approaches are just used for research purpose and have not been implemented as publicly availab... | ['Animals', 'Bayes Theorem', 'Computational Biology', 'Computer Graphics', 'Computer Simulation', 'Databases, Genetic', 'Genomics', 'Mice', 'Models, Genetic', 'Models, Statistical', 'Phylogeny', 'Protein Interaction Mapping', 'Protein Structure, Tertiary', 'Software'] | 20,054,992 | [['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.108', 'L01.296.110'], ['L01.224.160'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Prevalence of persistent pain in the U.S. adult population: new data from the 2010 national health interview survey. | UNLABELLED: Published adult prevalence estimates of chronic pain in the United States vary significantly. A more consistent pain measure is needed to assess unmet need for pain management in the general population. In this study, secondary analyses of the 2010 Quality of Life Supplement of the National Health Interview... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Prevalence', 'United States', 'Young Adult'] | 25,267,013 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Sj?gren syndrome: central nervous system manifestations. | We studied eight patients who had primary Sj?gren syndrome and central nervous system (CNS) disorders that were not attributable to other causes. Focal cerebral deficits were observed in five patients. Aseptic meningoencephalitis was seen in five patients, recurrent in one. Spinal cord manifestations in three patients ... | ['Adult', 'Brain', 'Female', 'Hemiplegia', 'Humans', 'Male', 'Middle Aged', 'Muscular Diseases', 'Nervous System Diseases', 'Peripheral Nervous System Diseases', "Sjogren's Syndrome", 'Tomography, X-Ray Computed'] | 6,273,765 | [['M01.060.116'], ['A08.186.211'], ['C10.597.622.295', 'C23.888.592.636.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.651', 'C10.668.491'], ['C10'], ['C10.668.829'], ['C05.550.114.154.774', 'C05.799.114.774', 'C07.465.815.929.669', 'C11.496.260.719', 'C17.300.775.099.774', 'C20.111.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Red bone marrow dose estimation using several internal dosimetry models for prospective dosimetry-oriented radioiodine therapy. | The aim of the present study was to review the available models developed for calculating red bone marrow dose in radioiodine therapy using clinical data. The study includes 18 patients (12 females and six males) with metastatic differentiated thyroid cancer. Radioiodine tracer of 73 ± 16 MBq 131I was orally administer... | ['Bone Marrow', 'Female', 'Humans', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Prospective Studies', 'Radiation Dosage', 'Radiometry'] | 30,298,289 | [['A15.382.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.799']] | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An Assessment of Perceived Barriers to Farmers' Market Access. | OBJECTIVE: To explore whether Supplemental Nutrition Assistance Program-Education (SNAP-Ed) stakeholders (individuals involved in work to increase access to farmers' markets [FMs] for low-income populations) perceive the same barriers to shopping at FMs as those reported by SNAP participants in Washington State.DESIGN:... | ['Adolescent', 'Adult', 'Aged', 'Attitude to Health', 'Farmers', 'Female', 'Food Assistance', 'Food Supply', 'Fruit', 'Health Promotion', 'Humans', 'Male', 'Middle Aged', 'Socioeconomic Factors', 'Vegetables', 'Washington', 'Young Adult'] | 30,249,521 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['M01.526.390'], ['I01.880.787.839.500', 'N03.219.521.346.506.281'], ['J01.576.423.750'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Evaluation on the efficacy of recombinant hepatitis B vaccine booster immunization in 2789 children aged over 10 years]. | OBJECTIVE: To study the efficiency of booster immunization with different recombinant hepatitis B vaccines.METHODS: 2789 children aged over 10 years who had completed the basic immunization of hepatitis B vaccine under 1 year old were selected. All the sampled children were classified into four groups (A, B, C and D) a... | ['Child', 'Hepatitis B', 'Hepatitis B Antibodies', 'Hepatitis B Vaccines', 'Humans', 'Immunization, Secondary'] | 21,457,659 | [['M01.060.406'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D12.776.124.486.485.114.254.450.504', 'D12.776.124.790.651.114.254.450.504', 'D12.776.377.715.548.114.254.450.504'], ['D20.215.894.899.955.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.4... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification and re-addressing of a transcriptionally permissive locus in the porcine genome. | Recently, we established the Sleeping Beauty transposon system for germ line competent transgenesis in the pig. Here, we extend this approach to re-target a transposon-tagged locus for a site-specific gene knock-in, and generated a syngeneic cohort of piglets carrying either the original transposon or the re-targeted e... | ['Animals', 'Animals, Genetically Modified', 'DNA Transposable Elements', 'Female', 'Gene Transfer Techniques', 'Genetic Engineering', 'Genetic Loci', 'Genome', 'Green Fluorescent Proteins', 'Male', 'Microsatellite Repeats', 'Nuclear Transfer Techniques', 'Sus scrofa', 'Transgenes'] | 26,515,985 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['E05.393.350'], ['E05.393.420'], ['G05.360.340.024.380'], ['G05.360.340'], ['D12.776.532.265'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats. | To date, the pharmacological approach to cerebral vasospasm following subarachnoid hemorrhage has been hampered in part by an inability to attain sufficiently high concentrations of vasodilator drugs in the cerebrospinal fluid (CSF). To overcome this limitation of current drug therapy, we have developed a sustained-rel... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'Animals', 'Basilar Artery', 'Drug Delivery Systems', 'Injections, Spinal', 'Liposomes', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Subarachnoid Hemorrhage', 'Vasoconstriction', 'Vasodilator Agents', 'Vasospasm, Intracranial'] | 11,683,605 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['B01.050'], ['A07.015.114.106'], ['E02.319.300'], ['E02.319.267.530.580'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evaluation of hepatic function in liver cirrhosis: clinical utility of galactose elimination capacity, hepatic clearance of D-sorbitol, and laboratory investigations. | Assessment of hepatic function is based on both liver blood tests and functional tests, the extensive application of which is still controversial. The aim of this study was to evaluate the clinical utility of a few selected tests as discriminatory and prognostic indexes: serum albumin, pseudocholinesterase, prothrombin... | ['Adolescent', 'Adult', 'Aged', 'Butyrylcholinesterase', 'Child', 'Female', 'Galactose', 'Humans', 'Liver Cirrhosis', 'Liver Function Tests', 'Male', 'Middle Aged', 'Partial Thromboplastin Time', 'Predictive Value of Tests', 'Prognosis', 'Sensitivity and Specificity', 'Serum Albumin', 'Severity of Illness Index', 'Sorb... | 10,219,839 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.277.352.100.170.250'], ['M01.060.406'], ['D09.947.875.359.377'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['E01.370.372.460'], ['M01.060.116.630'], ['E01.370.225.625.115.600', 'E05.200.625.115.600', 'G09.188.66... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptome Analysis of Syringa oblata Lindl. Inflorescence Identifies Genes Associated with Pigment Biosynthesis and Scent Metabolism. | Syringa oblata Lindl. is a woody ornamental plant with high economic value and characteristics that include early flowering, multiple flower colors, and strong fragrance. Despite a long history of cultivation, the genetics and molecular biology of S. oblata are poorly understood. Transcriptome and expression profiling ... | ['Flowers', 'Gene Expression Regulation, Plant', 'High-Throughput Nucleotide Sequencing', 'Molecular Sequence Annotation', 'Plant Proteins', 'Syringa', 'Transcriptome'] | 26,587,670 | [['A18.024.249.500'], ['G05.308.375'], ['E05.393.760.319'], ['E05.393.760.479', 'L01.453.245.667.580'], ['D12.776.765'], ['B01.650.940.800.575.912.250.583.640.833'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Anti-diabetes and hypoglycaemic properties of Hemionitis arifolia (Burm.) Moore in rats. | Hemionitis arifolia, a folklore anti-diabetes fern, was evaluated for its hypoglycaemic and anti-diabetic properties using rats. Glucose lowering effect and anti-diabetes activity were studied using glucose tolerance test in normal rats and alloxan diabetic rats, respectively. When different extracts were tested, the e... | ['Alloxan', 'Animals', 'Blood Glucose', 'Body Weight', 'Diabetes Mellitus, Experimental', 'Ferns', 'Glucose Tolerance Test', 'Glycogen', 'Hypoglycemic Agents', 'India', 'Liver', 'Mice', 'Plant Extracts', 'Plants, Medicinal', 'Rats', 'Rats, Wistar'] | 16,442,253 | [['D03.383.742.698.122'], ['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['B01.650.940.800.575.912.063'], ['E01.370.225.124.100.355', 'E01.370.374.35... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Genomic footprinting and sequencing of human beta-globin locus. Tissue specificity and cell line artifact. | In order to gain further insights of the regulatory mechanisms of human beta-like globin gene switch during erythroid development, we have studied protein-DNA interaction in vivo at the human adult beta and fetal gamma globin promoters and their upstream enhancer, 5'HS-2, in purified human adult erythroblasts, in which... | ['Adult', 'Animals', 'Artifacts', 'Base Sequence', 'Cell Line', 'Conserved Sequence', 'DNA', 'DNA Primers', 'DNA-Binding Proteins', 'Enhancer Elements, Genetic', 'Erythroblasts', 'Erythroid-Specific DNA-Binding Factors', 'Fetus', 'GATA1 Transcription Factor', 'Genome, Human', 'Globins', 'HeLa Cells', 'Hominidae', 'Huma... | 8,132,552 | [['M01.060.116'], ['B01.050'], ['E05.047'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['G02.111.570.580'], ['D13.444.308'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D12.776.260'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249']... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Risk factor analysis for meralgia paresthetica: A hospital-based study in Taiwan. | Recognizing the cause is essential for the management of meralgia paresthetica (MP), also known as lateral femoral cutaneous neuropathy. The aim of this study was to investigate the etiologies of MP and their influence on each other. This retrospective study enrolled referral patients with electromyographic studies who... | ['Adult', 'Female', 'Femoral Neuropathy', 'Hospitals', 'Humans', 'Male', 'Middle Aged', 'Nerve Compression Syndromes', 'Retrospective Studies', 'Risk Factors', 'Taiwan'] | 28,511,974 | [['M01.060.116'], ['C10.668.829.500.200'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.668.829.550'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Is changing hospitals for revision total joint arthroplasty associated with more complications? | BACKGROUND: Many patients change hospitals for revision total joint arthroplasty (TJA). The implications of changing hospitals must be better understood to inform appropriate utilization strategies.QUESTIONS/PURPOSES: (1) How frequently do patients change hospitals for revision TJA? (2) Which patient, community, and ho... | ['Age Factors', 'Aged', 'Arthroplasty, Replacement', 'Chi-Square Distribution', 'Female', 'Health Services Accessibility', 'Hospital Costs', 'Hospitalization', 'Hospitals, High-Volume', 'Hospitals, Low-Volume', 'Humans', 'Male', 'Medicare', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Patient Readmission', 'P... | 24,615,420 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N04.590.374.350', 'N05.300.430'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['E02.760.... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
In vitro evaluation of the antioxidant activity of liposomal flavonols by the HRP-H2O2-luminol system. | Considering that antioxidant flavonols have been reported to be beneficial to human health, but that their low water solubility and bioavailability limit their administration through systemic route, the development of suitable flavonol-carriers is of great importance for clinical therapeutics. The aim of this study was... | ['Antioxidants', 'Drug Evaluation, Preclinical', 'Flavonols', 'Horseradish Peroxidase', 'Humans', 'Hydrogen Peroxide', 'Liposomes', 'Luminol'] | 21,545,317 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.290.750', 'E05.337.550'], ['D03.383.663.283.266.450.284', 'D03.633.100.150.266.450.284'], ['D08.811.682.732.512'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Putrescine as an important source of GABA in the postnatal rat subventricular zone. | The subventricular zone (SVZ) is a neurogenic region that continually gives rise to olfactory bulb (OB) GABAergic interneurons in mammals. The newly generated neuroblasts already express GABA while migrating to this structure along the rostral migratory stream (RMS). Here, we investigate in early postnatal rat if SVZ/R... | ['Animals', 'Animals, Newborn', 'Cerebral Ventricles', 'Glutamate Decarboxylase', 'Immunohistochemistry', 'In Vitro Techniques', 'Olfactory Bulb', 'Putrescine', 'Rats', 'Rats, Wistar', 'gamma-Aminobutyric Acid'] | 17,395,389 | [['B01.050'], ['B01.050.050.282'], ['A08.186.211.140'], ['D08.811.520.224.125.250'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'],... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Direct bladder stimulation with percutaneous electrodes and impedance monitoring of volume in an SCI animal model. | Bladder responses to percutaneous electrodes were investigated with stimulation in three male spinal cats. The animals had been spinalized (T1 level lesion) 10 weeks prior to these studies and had been instrumented with chronic bladder had been spinalized (T1 level lesion) 10 weeks prior to these studies and had been i... | ['Animals', 'Cats', 'Electric Impedance', 'Electric Stimulation Therapy', 'Electrodes, Implanted', 'Electrophysiology', 'Male', 'Monitoring, Physiologic', 'Spinal Cord Injuries', 'Transcutaneous Electric Nerve Stimulation', 'Urinary Bladder'] | 7,640,980 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G01.358.500.249.277.350'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E07.305.250.319', 'E07.695.202'], ['H01.158.344.528', 'H01.158.782.236'], ['E01.370.520'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['E02.331.800', 'E02.779.468.800', 'E02.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Endoscopic treatment strategy of obstructive hydrocephalus induced by pineal region tumors]. | OBJECTIVE: To explore the efficacies of endoscopic third ventriculostomy (ETV) and tumor biopsy in surgical treatment of obstructive hydrocephalus induced by pineal region tumors.METHODS: For 65 patients of obstructive hydrocephalus induced by pineal region tumors, endoscopic third ventriculostomy (ETV) and tumor biops... | ['Antineoplastic Combined Chemotherapy Protocols', 'Biopsy', 'Bleomycin', 'Brain Neoplasms', 'Cisplatin', 'Craniotomy', 'Etoposide', 'Humans', 'Hydrocephalus', 'Neuroendoscopy', 'Pineal Gland', 'Pinealoma', 'Treatment Outcome', 'Ventriculostomy'] | 26,080,918 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D09.400.420.110', 'D12.644.233.110'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D01.210.375'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Identification and characterization of HIV-1 latent viral reservoirs in peripheral blood. | Plasma viral load and CD4 counts are effective for clinical monitoring, but they do not give a full representation of HIV-1 quasispecies in cellular reservoirs, the major repository of replication-competent HIV-1 in infected individuals. We sought to develop a diagnostic system that might stimulate the replication-comp... | ['Antiretroviral Therapy, Highly Active', 'CD4 Lymphocyte Count', 'CD4-Positive T-Lymphocytes', 'Genotype', 'HIV Infections', 'HIV-1', 'Humans', 'Leukocytes, Mononuclear', 'Reassortant Viruses', 'Viral Load', 'Virus Latency', 'Virus Replication'] | 25,339,403 | [['E02.319.310.075'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute glaucoma in the presence of patent neodymium: YAG laser iridotomies. | Nd:YAG laser iridotomy is being used in the treatment of angle closure glaucoma with increasing frequency. Failure is uncommon, but 3 cases are presented here in which intra-ocular pressure rose despite a patent iridotomy. Possible reasons for this are discussed. | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Female', 'Glaucoma, Angle-Closure', 'Humans', 'Intraocular Pressure', 'Iris', 'Laser Therapy', 'Male', 'Middle Aged', 'Ophthalmic Solutions', 'Reoperation'] | 2,028,772 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.525.381.056'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['A09.371.060.450', 'A09.371.894.513'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['D26.776.708.645', 'D27.505.954.578.645', 'D27.720.752.608'], ['E04.690']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Alkaloids of the hairy roots of Ipomoea batatas Lam]. | AIM: To study the alkaloid constituents of the hairy roots of Ipomoea batatas Lam.METHODS: Chromatographic methods were used for isolation and purification. The structure was elucidated on the basis of spectral data.RESULTS: An alkaloid was isolated from the hairy roots of Ipomoea batatas.CONCLUSION: The compound is a ... | ['Indole Alkaloids', 'Ipomoea batatas', 'Molecular Conformation', 'Molecular Structure', 'Plant Roots', 'Plants, Medicinal'] | 15,700,823 | [['D03.132.436', 'D03.633.100.473.402', 'D03.633.100.496.500.500'], ['B01.650.940.800.575.912.250.238.500.500'], ['G02.111.570.820'], ['G02.111.570', 'G02.466'], ['A18.400'], ['B01.650.560']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis. | BACKGROUND: The present study was performed to statistically explore the effect of anthrax toxin receptor 2 (ANTXR2) polymorphism rs4333130 on individual susceptibility to ankylosing spondylitis (AS) using the method of meta-analysis.METHODS: All of the eligible reports were retrieved from well-known electronic databas... | ['Humans', 'Polymorphism, Single Nucleotide', 'Protective Factors', 'Receptors, Peptide', 'Spondylitis, Ankylosing'] | 32,664,053 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['E05.318.740.600.800.582', 'N05.715.350.200.675', 'N05.715.360.750.625.700.570', 'N06.850.490.625.625', 'N06.850.520.830.600.800.582'], ['D12.776.543.750.750'], ['C05.116.900.853.625.800.850', 'C05.550.069.680', 'C05.550.114.865.800.850']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Photooxidation tolerance characters of a new purple pepper. | Huai Zi (HZ) is a new purple mutant of green pepper (PI 631133) that is obtained from the United States Department of Agriculture. The net photosynthetic rate (P N), chlorophyll fluorescence parameters, antioxidant substances, antioxidant enzymes, photosystem 1 (PS1) and PS2 activities were studied through methyl violo... | ['Adaptation, Physiological', 'Antioxidants', 'Capsicum', 'Chlorophyll', 'Fluorescence', 'Gases', 'Kinetics', 'Light', 'Oxidation-Reduction', 'Photosynthesis', 'Photosystem I Protein Complex', 'Photosystem II Protein Complex', 'Pigmentation'] | 23,704,924 | [['G07.025', 'G16.012.500'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.650.940.800.575.912.250.908.500.145'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D01.362'], ['G01.374.661', 'G02.111.490'], ['G01.358.5... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Underdiagnosed menorrhagia in adolescents is associated with underdiagnosed anemia. | OBJECTIVE: To test the hypothesis that adolescent girls with menorrhagia rarely seek medical attention.STUDY DESIGN: A total of 705 adolescent girls attended a lecture on menorrhagia, completed an initial anonymous questionnaire, and were asked to participate in a more comprehensive study comprising a detailed bleeding... | ['Adolescent', 'Anemia', 'Female', 'Humans', 'Menorrhagia', 'Surveys and Questionnaires'] | 21,925,680 | [['M01.060.057'], ['C15.378.071'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.852.691.449', 'C23.550.414.993.350', 'C23.550.568.875'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Clinical and immunological changes in atopic dermatitis patients treated with purified staphylococcal toxoid]. | 32 patients with atopic dermatitis (AD), complicated by pyoderma, were treated with purified staphylococcal toxoid (PST). Changes in clinical and laboratory characteristics in the course of treatment were evaluated. PST was shown to produce a satisfactory therapeutic effect, arresting the symptoms of local staphylococc... | ['Adolescent', 'Adult', 'Child', 'Dermatitis, Atopic', 'Humans', 'Interferon Inducers', 'Interferon-alpha', 'Interferon-gamma', 'Lymphocyte Count', 'Lymphocytes', 'Pyoderma', 'Receptors, Interleukin-2', 'Staphylococcal Infections', 'Staphylococcal Toxoid'] | 15,024,988 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.828'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250'], ['D12.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Screening for glycosylation changes on recombinant human IgG using lectin methods. | Two lectin-binding methods were investigated as possible ways of monitoring the glycosylation of human monoclonal antibodies during their development and production. Carbohydrate composition was assessed in various preparations that were produced in different host cell types, cell sublines or batches of the same cells.... | ['Enzyme-Linked Immunosorbent Assay', 'Glycosylation', 'Humans', 'Immunoassay', 'Immunoglobulin G', 'Lectins', 'Recombinant Proteins', 'Species Specificity', 'Surface Plasmon Resonance'] | 12,578,544 | [['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors shaping interactions among community health workers in rural Ethiopia: rethinking workplace trust and teamwork. | INTRODUCTION: Worldwide, a shortage of skilled health workers has prompted a shift toward community-based health workers taking on greater responsibility in the provision of select maternal and newborn health services. Research in mid- and high-income settings suggests that coworker collaboration increases productivity... | ['Adult', 'Aged', 'Community Health Workers', 'Cooperative Behavior', 'Cross-Sectional Studies', 'Data Collection', 'Delivery of Health Care', 'Ethiopia', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Maternal Health Services', 'Middle Aged', 'Midwifery', 'Motivation', 'Pregnancy', 'Rural Health Services', 'Rural Pop... | 24,588,914 | [['M01.060.116'], ['M01.060.116.100'], ['M01.526.485.067.080', 'N02.360.067.080'], ['F01.145.813.115'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['N04.590.374', 'N05.300'], ['Z01.058.290.120.310'], ['B01.050.150.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Soc... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
A new technology for the production of valuable vitamin extracts from wheat and rye germs. | A method for nearly complete extraction of the lipid fraction from wheat and rye germs was developed, and the technological parameters of the production process were specified. The resulting preparations are extracts rich in vitamin E and other biologically active components. Dermatological studies and application in t... | ['Chemical Phenomena', 'Chemistry, Physical', 'Edible Grain', 'Lipids', 'Secale', 'Technology, Pharmaceutical', 'Triticum', 'Vitamins'] | 3,231,240 | [['G02'], ['H01.181.529'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02.500.775.500'], ['D10'], ['B01.650.940.800.575.912.250.822.857'], ['E05.916', 'J01.897.836'], ['B01.650.940.800.575.912.250.822.918'], ['D27.505.696.494.600', 'G0... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Changes in depression and personal construing following assessment for dynamic psychotherapy. | This paper reports a study based on a group of 12 out-patients whose mood and personal construing were monitored before and after assessment of suitability for dynamic psychotherapy. Changes in the construct system were found, but not in the predicted direction. These changes included reduced differentiation, tightenin... | ['Adaptation, Psychological', 'Adult', 'Depressive Disorder', 'Female', 'Humans', 'Internal-External Control', 'Male', 'Personality Assessment', 'Psychoanalytic Therapy', 'Self Concept', 'Social Isolation', 'Social Perception'] | 1,571,311 | [['F01.058'], ['M01.060.116'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['F04.513'], ['F04.754.709'], ['F01.752.747.792'], ['F01.145.813.781', 'I01.880.853.748'], ['F02.463.593.752']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Size distribution of bioaerosols from biomass burning emissions: Characteristics of bacterial and fungal communities in submicron (PM1.0 | The North China Plain is the agricultural heartland in China. High PM2.5 levels and elevated chemical pollutants have been observed during crop harvest seasons due to open biomass burning. Biomass burning in the wheat-harvest season may significantly deteriorate the regional air quality. The harmful ingredients in smok... | ['Aerosols', 'Agriculture', 'Air Pollutants', 'Air Pollution', 'Alternaria', 'Bacillus', 'Bacteria', 'Biomass', 'Environmental Monitoring', 'Fires', 'Fungi', 'Humans', 'Particle Size', 'Particulate Matter', 'Pseudomonas', 'Rhodospirillaceae'] | 30,594,755 | [['D20.280.055', 'D26.255.165.055'], ['J01.040'], ['D27.888.284.101'], ['N06.850.460.100'], ['B01.300.381.075'], ['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['B03'], ['G16.500.275.157.100', 'N06.230.124.100'], ['N06.850.460.350.080', '... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Aurantio-obtusin stimulates chemotactic migration and differentiation of MC3T3-E1 osteoblast cells. | Osteoporosis is one of the major metabolic bone diseases and is among the most challenging noncommunicable diseases to treat. Although there is an increasing interest in identifying bioactive molecules for the prevention and management of osteoporosis, such studies principally focus only on differentiation and minerali... | ['Animals', 'Anthraquinones', 'Calcification, Physiologic', 'Cassia', 'Cell Differentiation', 'Cell Line', 'Chemotaxis', 'Humans', 'Mice', 'Osteoblasts', 'Osteoporosis', 'Seeds'] | 24,841,966 | [['B01.050'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['B01.650.940.800.575.912.250.401.100'], ['G04.152'], ['A11.251.210'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.59... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cost-effectiveness of everolimus-eluting versus bare-metal stents in ST-segment elevation myocardial infarction: An analysis from the EXAMINATION randomized controlled trial. | BACKGROUND: Use of everolimus-eluting stents (EES) has proven to be clinically effective and safe in patients with ST-segment elevation myocardial infarction but it remains unclear whether it is cost-effective compared to bare-metal stents (BMS) in the long-term. We sought to assess the cost-effectiveness of EES versus... | ['Cost-Benefit Analysis', 'Drug-Eluting Stents', 'Everolimus', 'Follow-Up Studies', 'Health Care Costs', 'Humans', 'Patient Outcome Assessment', 'Proportional Hazards Models', 'ST Elevation Myocardial Infarction', 'Stents'] | 30,114,230 | [['N03.219.151.125'], ['E07.695.750.500'], ['D02.540.505.760.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.559.590.399', 'N05.715.360.575.575.399'], ['E05.318.740.500.700', ... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Morphological factors influencing the penetration of human sperm into cervical mucus in vitro. | The efficiency of cervical mucus in filtering out single, multiple and associated abnormalities of human spermatozoa was determined. Twenty semen samples which gave a normal in vitro cervical mucus penetration test (CMPT) were analysed before and after migration using a detailed classification system (13 categories). T... | ['Cervix Mucus', 'Female', 'Humans', 'Male', 'Semen', 'Sperm-Ovum Interactions', 'Spermatozoa'] | 4,055,086 | [['A12.200.503.339'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.200.732'], ['G08.686.784.277.800'], ['A05.360.490.890', 'A11.497.760']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Application of 360 degree circular decompression and transpedicle screw fixation in the treatment of ossification of thoracic posterior longitudinal ligament by posterior approach]. | OBJECTIVE: To investigate the clinical effects of 360 degree circular decompression and transpedicle screw fixation to treat the ossification of thoracic posterior longitudinal ligament by posterior approach.METHODS: From December 2009 to November 2013, 18 patients with ossification of thoracic posterior longitudinal l... | ['Adult', 'Aged', 'Decompression, Surgical', 'Female', 'Fracture Fixation, Internal', 'Humans', 'Male', 'Middle Aged', 'Ossification of Posterior Longitudinal Ligament', 'Thoracic Vertebrae'] | 27,141,789 | [['M01.060.116'], ['M01.060.116.100'], ['E04.188'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.116.900.480', 'C23.550.751.500'], ['A02.835.232.834.892']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of an automatic seizure detection method for the newborn EEG. | In another publication, we described a set of methods for automatic detection of EEG seizures in the newborn. We describe here the evaluation of these methods using a completely new set of data, which were not used in developing the method. This testing data set consisted of recording from 54 patients, lasting an avera... | ['Electroencephalography', 'Epilepsy', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male'] | 9,305,283 | [['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides. | Chronic inflammatory diseases, such as arthritis and rheumatoid arthritis, remain major health problems worldwide. We previously demonstrated that adenosine kinase inhibitors (AKIs) exhibit antiinflammatory effects by inhibiting TNF-alpha production, neutrophil accumulation, and edema formation. Although adenosine rece... | ['Adenosine Kinase', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Dose-Response Relationship, Drug', 'Edema', 'Leukocyte Count', 'Neutrophils', 'Nucleosides', 'Phosphorylation', 'Purinergic P1 Receptor Antagonists', 'Rats', 'Skin', 'Structure-Activity Relationship', 'Theobromine'] | 14,561,094 | [['D08.811.913.696.620.010'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G07.690.773.875', 'G07.690.936.500'], ['C23.888.277'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survey of the European Psychiatric Association on the European status and perspectives in early detection and intervention in at-risk mental state and first-episode psychosis. | AIM: Early detection/early intervention (ED/EI) programmes have been inconsistently implemented throughout Europe. We evaluated the ED/EI service distribution in European Psychiatric Association (EPA) member countries, considering indicators of socio-economic development, human and financial resources allocated in ment... | ['Cross-Sectional Studies', 'Early Diagnosis', 'Early Medical Intervention', 'Europe', 'Health Resources', 'Humans', 'Mental Health Services', 'Psychotic Disorders', 'Societies, Medical', 'Surveys and Questionnaires', 'Time Factors', 'Time-to-Treatment'] | 29,882,272 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.390'], ['N02.421.726.363'], ['Z01.542'], ['N03.349.340', 'N05.300.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.408', 'N02.421.461'], ['F03.700.675'], ['N03.540.828.589'], ['E05.318.308.980', 'N05.715.360.300.800', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Application of DNA microcarriers for evaluation of mice splenocytes genes expression after immunization with pertussis vaccines and challenged with different B. pertussis strains]. | The study aimed at identification of splenocytes genes expression induced after immunization with whole-cell or acellular pertussis vaccines and subsequent challenge with B. pertussis strains of different ptxS1/prn genes alleles in correlation with differences in bacteria elimination from the lung tissue. Investigation... | ['Administration, Intranasal', 'Alleles', 'Animals', 'Antigens, Bacterial', 'Bacterial Outer Membrane Proteins', 'Bordetella pertussis', 'Cells, Cultured', 'Diphtheria-Tetanus-Pertussis Vaccine', 'Diphtheria-Tetanus-acellular Pertussis Vaccines', 'Gene Expression Regulation', 'Immunization', 'Mice', 'Mice, Inbred BALB ... | 17,929,412 | [['E02.319.267.120.655.500'], ['G05.360.340.024.340.030'], ['B01.050'], ['D23.050.161'], ['D12.776.097.120', 'D12.776.543.100'], ['B03.440.400.425.115.425.600', 'B03.660.075.090.344.425.600'], ['A11.251'], ['D20.215.894.135.535.300', 'D20.215.894.691.263.300', 'D20.215.894.691.824.300', 'D20.215.894.815.300'], ['D20.21... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Colorectal responses to distension and feeding in patients with spinal cord injury. | The role of the central nervous system in enteroenteric motor reflexes remains controversial. Our aims were as follows: 1) to evaluate colorectal, rectocolic, gastrocolonic, and gastrorectal reflex responses in patients with cervical spinal cord injury (SCI) and 2) to compare these responses with those in healthy subje... | ['Adult', 'Catheterization', 'Colon', 'Eating', 'Female', 'Gastrointestinal Motility', 'Humans', 'Male', 'Middle Aged', 'Neural Pathways', 'Pressure', 'Rectum', 'Reflex', 'Spinal Cord Injuries'] | 19,359,420 | [['M01.060.116'], ['E02.148', 'E05.157'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['G07.203.650.283', 'G10.261.330'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.612'], ['G01.374.715'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['E01.370.376.550.650', 'E01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
YWHAE Rearrangement in a Purely Conventional Low-grade Endometrial Stromal Sarcoma that Transformed Over Time to High-grade Sarcoma: Importance of Molecular Testing. | Low and high-grade endometrial stromal sarcomas (ESS) can be distinguished on a morphologic basis. Low-grade ESS is composed of oval cells that resemble normal proliferative-phase endometrial stroma, while the well-known high-grade ESS is composed of round cells growing in nests separated by delicate sinusoidal vascula... | ['14-3-3 Proteins', 'Cell Transformation, Neoplastic', 'Endometrial Neoplasms', 'Fatal Outcome', 'Female', 'Gene Rearrangement', 'Humans', 'Middle Aged', 'Neoplasm Metastasis', 'Sarcoma, Endometrial Stromal'] | 28,863,072 | [['D12.644.360.024.050', 'D12.776.157.057.002', 'D12.776.476.024.050'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['G05.3... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro synthesis of vaccinia virus late mRNA containing a 5' poly(A) leader sequence. | We have shown that an extract made from HeLa cells harvested 6 hr after infection with vaccinia virus can transcribe a duplex DNA template containing a late viral gene. S1 nuclease analyses using genomic and synthetic probes indicated that the 5' ends of RNA synthesized in vitro are similar to those of RNA made in vivo... | ['Cell-Free System', 'Endonucleases', 'Genes, Viral', 'HeLa Cells', 'Poly A', 'RNA Processing, Post-Transcriptional', 'RNA, Messenger', 'RNA, Viral', 'Single-Strand Specific DNA and RNA Endonucleases', 'Transcription, Genetic', 'Vaccinia virus'] | 2,827,158 | [['A11.284.835.168'], ['D08.811.277.352.355'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['D13.695.578.550.500'], ['G02.111.760', 'G03.839', 'G05.308.700'], ['D13.444.735.544'], ['D13.444.735.828'], ['D08.811.277... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma. | The molecular basis of tumorigenesis and tumor progression in meningiomas is not fully understood. The neurofibromatosis 2 (NF2) locus is inactivated in 50-60% of sporadic meningiomas, but the genetic basis of sporadic meningiomas not inactivated at the NF2 locus remains unclear. Specifically, there is conflicting data... | ['Chromosomes, Human, Pair 18', 'Chromosomes, Human, Pair 22', 'Genes, Neurofibromatosis 2', 'Genes, Tumor Suppressor', 'Humans', 'Loss of Heterozygosity', 'Membrane Proteins', 'Meningeal Neoplasms', 'Meningioma', 'Microfilament Proteins', 'Microsatellite Repeats', 'Tumor Suppressor Proteins'] | 16,213,361 | [['A11.284.187.520.300.415.430', 'G05.360.162.520.300.415.430'], ['A11.284.187.520.300.505.515', 'G05.360.162.520.300.505.515'], ['G05.360.340.024.340.375.249.345', 'G05.360.340.024.340.415.400.345'], ['G05.360.340.024.340.375.249', 'G05.360.340.024.340.415.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Leiomyoma of the prostate: CT and MR findings. | Pure prostatic leiomyoma is very rare. We report a case of magnetic resonance imaging findings of prostatic leiomyoma. The mass was expansile and had a slightly higher signal intensity than skeletal muscle on T2-weighted images. Normal prostatic glandular tissue could be clearly distinguished from the tumor. | ['Aged', 'Humans', 'Leiomyoma', 'Magnetic Resonance Imaging', 'Male', 'Prostate', 'Prostatic Neoplasms', 'Tomography, X-Ray Computed'] | 12,395,254 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.450'], ['E01.370.350.825.500'], ['A05.360.444.575', 'A10.336.707'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810',... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Total prostatectomy for cancer. Mortality and morbidity. Apropos of 1288 operations. The ANFUC survey]. | A retrospective survey of total prostatectomies performed for cancer was conducted by 30 urologists members of the French Association of Continuing Education (ANFUC). This survey was limited to the operation itself and perioperative complications observed during hospitalization. Urinary sequellae including incontinence... | ['Humans', 'Length of Stay', 'Lymph Node Excision', 'Male', 'Postoperative Complications', 'Prostatectomy', 'Prostatic Neoplasms', 'Retrospective Studies'] | 8,089,528 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E04.446'], ['C23.550.767'], ['E04.950.774.860.625'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Questioning the evidence for Earth's oldest fossils. | Structures resembling remarkably preserved bacterial and cyanobacterial microfossils from about 3,465-million-year-old Apex cherts of the Warrawoona Group in Western Australia currently provide the oldest morphological evidence for life on Earth and have been taken to support an early beginning for oxygen-producing pho... | ['Artifacts', 'Bacteria', 'Carbon Isotopes', 'Crystallization', 'Cyanobacteria', 'Fossils', 'Image Processing, Computer-Assisted', 'Microbiological Techniques', 'Minerals', 'Spectrum Analysis, Raman', 'Time'] | 11,882,895 | [['E05.047'], ['B03'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.300', 'G02.171'], ['B03.280', 'B03.440.475.100'], ['I01.076.368.584.311'], ['L01.224.308'], ['E01.370.225.875', 'E05.200.875'], ['D01.578'], ['E05.196.822.860', 'E05.196.867.890'], ['G01.910']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice. | BACKGROUND: Immediate early gene (IEG) induction elicited by drugs of abuse may contribute to development of plastic changes in the brain responsible for drug-induced behavioral changes leading to addiction. The aim of the present study was to characterize the changes in IEG expression in the striatum and nucleus accum... | ['Animals', 'Brain', 'Corpus Striatum', 'Genes, Immediate-Early', 'Male', 'Maze Learning', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Minocycline', 'Morphine', 'Motor Activity', 'Pyrroles', 'Species Specificity'] | 23,238,466 | [['B01.050'], ['A08.186.211'], ['A08.186.211.200.885.287.249.487'], ['G05.360.340.024.340.330', 'G05.360.340.024.340.364.875.345', 'G05.360.340.358.024.875.345', 'G05.360.340.358.840.500.345'], ['F02.463.425.874.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings. | UNLABELLED: Among individuals diagnosed with schizophrenia, approximately 20%-33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit from existing antipsychotic treatments. A few recent studies suggested that schizophrenia... | ['Adult', 'Brain', 'Connectome', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neuronal Plasticity', 'Schizophrenia', 'Siblings'] | 26,106,532 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500.249', 'E01.370.376.537.625.500.249', 'E05.629.875.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['G11.561.638'], ['F03.700.750'], ['F01.829.263.500.490', 'I01.880.853.150.500.505', 'M01.781']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
[Dental care and oral hygiene practices in long-term geriatric care institutions]. | This study evaluated the activities of dentists, dental care and oral hygiene practices in the long-term care institutions of Belo Horizonte (Minas Gerais, Brazil). A semi-structured questionnaire was handed out to the coordinators of 37 philanthropic and 30 private institutions. The data was compared by the chi-square... | ['Aged', 'Cross-Sectional Studies', 'Dental Care for Aged', 'Female', 'Homes for the Aged', 'Humans', 'Long-Term Care', 'Male', 'Oral Hygiene'] | 21,584,474 | [['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E06.170.100', 'N02.421.240.190.210'], ['J03.775.462', 'N02.278.825.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.476', 'N02.421.585.476'], ['E02.547.600', 'E06.761.726']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Surface topography of the female bladder trigone. | Cystoscopic biopsy specimens of the bladder trigone of young women with recurrent urinary infections were examined by scanning electron microscopy. The superficial cells of the thickened squamous epithelium of the trigone have either a microridged, microvillous, or mixed pattern. In one case, bacteria were found adhere... | ['Epithelium', 'Female', 'Humans', 'Microscopy, Electron, Scanning', 'Microvilli', 'Mucous Membrane', 'Urinary Bladder', 'Urinary Tract Infections'] | 7,229,108 | [['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A11.284.180.565'], ['A10.615.550'], ['A05.810.890'], ['C01.915', 'C12.777.892', 'C13.351.968.892']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Randomized phase 2 trial of ixazomib and dexamethasone in relapsed multiple myeloma not refractory to bortezomib. | Proteasome inhibitors have become an integral part of myeloma therapy. Considerable efforts have gone into optimizing this therapeutic approach to obtain maximal proteasome inhibition with least toxicity. Ixazomib is the first oral proteasome inhibitor to enter the clinic and has been studied as a single agent as well ... | ['Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Boron Compounds', 'Bortezomib', 'Dexamethasone', 'Drug Resistance, Neoplasm', 'Female', 'Glycine', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Neoplasm Recurrence, Local', 'Survival Analysis', 'Treatment Outcome'] | 27,702,799 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.132', 'D02.203'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G07.690.773.984.395'], ['D12.125.481'], ['B01.050.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phenomenological modelling of some mechanisms in schizophrenia. | The paper shows how mechanisms being important factors in the development and treatment of schizophrenia can be modelled in terms of differential equations in order to understand better the interplay of these mechanisms. As an example, the nigrostriatal loop is chosen which is an essential part of the basic model prese... | ['Antipsychotic Agents', 'Corpus Striatum', 'Humans', 'Models, Theoretical', 'Nerve Net', 'Neural Inhibition', 'Programming, Linear', 'Receptors, Dopamine', 'Receptors, Dopamine D2', 'Reference Values', 'Schizophrenia', 'Schizophrenic Psychology', 'Substantia Nigra', 'Synaptic Transmission'] | 16,508,895 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['A08.186.211.200.885.287.249.487'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['A08.511'], ['G07.265.755', 'G11.561.616'], ['L01.906.394.748'], ['D12.776.543.750.670.300.400', 'D12.776.543.750.695.150.400', ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cerebellar inhibition of inferior olivary transmission in the decerebrate ferret. | Stimulation around the superior cerebellar peduncle or within the deep cerebellar nuclei is known to inhibit the inferior olive with a very long latency. It has been suggested that this inhibition is mediated by the GABA-ergic nucleo-olivary pathway, but alternative explanations such as activation of an indirect excita... | ['Animals', 'Brain Mapping', 'Cerebellum', 'Conditioning, Eyelid', 'Decerebrate State', 'Electric Stimulation', 'Electromyography', 'Evoked Potentials', 'Ferrets', 'Neural Inhibition', 'Neural Pathways', 'Olivary Nucleus', 'Reaction Time'] | 16,132,968 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.132.810.428.200'], ['F02.463.425.179.408'], ['C10.597.305', 'C23.888.592.298'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.750.250.575.35... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemodialysis Patients Display a Declined Proportion of Th2 and Regulatory T Cells in Parallel with a High Interferon-ã Profile. | BACKGROUND: A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of ... | ['Aged', 'Case-Control Studies', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Flow Cytometry', 'Humans', 'Immunophenotyping', 'Interferon-gamma', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Renal Dialysis', 'T-Lymphocytes, Regulatory', 'Th2 Cells', 'Transcription Factors'] | 28,380,480 | [['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regulation of TGF-â receptor hetero-oligomerization and signaling by endoglin. | Complex formation among transforming growth factor-â (TGF-â) receptors and its modulation by coreceptors represent an important level of regulation for TGF-â signaling. Oligomerization of ALK5 and the type II TGF-â receptor (TâRII) has been thoroughly investigated, both in vitro and in intact cells. However, such studi... | ['Activin Receptors, Type II', 'Animals', 'Antigens, CD', 'COS Cells', 'Chlorocebus aethiops', 'Endoglin', 'Endothelial Cells', 'Fluorescence Recovery After Photobleaching', 'Humans', 'Protein Binding', 'Protein-Serine-Threonine Kinases', 'Receptor, Transforming Growth Factor-beta Type I', 'Receptors, Cell Surface', 'R... | 26,157,163 | [['D08.811.913.696.620.682.700.062.750', 'D12.776.543.750.750.400.820.500.750'], ['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D12.776.543.750.250'], ['A11.436.275'], ['E05.196.712.516.600.393'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Right cardiac echinococcosis with coronary compression. Description of a clinical case]. | An outstanding case of cardiac echinococcosis is described. Clinical symptomatology was characterized by typical nitroglycerin-responsive crisis of angina pectoris associated to an electrocardiographic pattern of negative T wave on anterolateral and inferior leads. The diagnosis was suspected on the basis of thoracic c... | ['Adult', 'Aortic Diseases', 'Cardiomyopathies', 'Constriction, Pathologic', 'Echinococcosis', 'Female', 'Humans'] | 3,792,735 | [['M01.060.116'], ['C14.907.109'], ['C14.280.238'], ['C23.300.287'], ['C01.610.335.190.396'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Axons break in animals lacking beta-spectrin. | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that beta-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in beta-spectrin mutants spontaneously break. Breakage is caused by acute st... | ['Animals', 'Axons', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Elasticity', 'Movement', 'Mutation', 'Nervous System Diseases', 'Neurons', 'Phenotype', 'Spectrin', 'Stress, Mechanical'] | 17,261,846 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['G01.374.590'], ['G07.568', 'G11.427.410'], ['G05.365.590'], ['C10'], ['A08.675', 'A11.671'], ['G05.695'], ['D12.776.220.980', 'D12.776.543.850'], ['G01.374.835']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro and in vivo studies of radiographic contrast media-induced histamine release in pigs. | Routine clinical use of radiographic contrast media (RCM) causes adverse reactions in some patients. To elucidate the mechanisms of these reactions both in vitro and in vivo studies are necessary. In this study, RCM-induced histamine release from isolated mast cells was compared with the in vivo release of histamine an... | ['Animals', 'Contrast Media', 'Female', 'Histamine', 'Histamine Release', 'Iohexol', 'Iopamidol', 'Iothalamic Acid', 'Kidney', 'Liver', 'Lung', 'Male', 'Mast Cells', 'Myocardium', 'Swine'] | 1,716,833 | [['B01.050'], ['D27.505.259.500', 'D27.720.259'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['G12.350'], ['D02.241.223.100.400.880.400', 'D02.455.426.559.389.127.375.880.400'], ['D02.241.223.100.400.880.410', 'D02.455.426.559.389.127.375.880.410'], ['D02.241.223.100.400.880.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ID-Check: Online Concealed Information Test Reveals True Identity. | The Internet has already changed people's lives considerably and is likely to drastically change forensic research. We developed a web-based test to reveal concealed autobiographical information. Initial studies identified a number of conditions that affect diagnostic efficiency. By combining these moderators, this stu... | ['Deception', 'Humans', 'Internet', 'Lie Detection', 'Reaction Time', 'Self Disclosure'] | 26,390,033 | [['F01.145.813.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F02.784.240.514', 'F02.830.512', 'I01.198.780.937.619'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F01.752.747.792.662']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Clinic visit frequency in wound care matters: data from the US wound registry. | OBJECTIVE: A previous study suggested that the frequency with which patients visit wound care clinics influences the rate of chronic wound healing but high bias was present with regard to wound care centre selection. The objective of this retrospective cohort study was to confirm this finding by using a very large samp... | ['Ambulatory Care', 'Cohort Studies', 'Diabetic Foot', 'Female', 'Humans', 'Male', 'Middle Aged', 'Proportional Hazards Models', 'Registries', 'Retrospective Studies', 'Time Factors', 'United States', 'Wound Healing'] | 28,105,899 | [['E02.760.106', 'N02.421.585.106'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C14.907.320.191', 'C17.800.893.592.450.200', 'C19.246.099.500.191', 'C19.246.099.937.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.500.700', 'E05.318.740.600... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Trabectome surgery for primary and secondary open angle glaucomas. | PURPOSE: In most forms of open angle glaucoma, the trabecular meshwork is the main barrier for aqueous humor outflow, causing elevated intraocular pressure (IOP). The Trabectome is a minimal invasive device for the surgical treatment of open angle glaucoma, particularly eliminating the juxtacanalicular meshwork. This s... | ['Adult', 'Aged', 'Exfoliation Syndrome', 'Female', 'Follow-Up Studies', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Intraoperative Complications', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Postoperative Complications', 'Prospective Studies', 'Tonometry, Ocular', 'Trabecular Meshw... | 24,158,374 | [['M01.060.116'], ['M01.060.116.100'], ['C11.941.375.285'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['C23.550.505'], ['M01.060.116.630'], ['E04.502'], ['C23.550.767'], ['E05.318.372.500.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Alpha-sulfanyl and alpha-selanyl propadienyl cations: regioselective generations and cycloadditions with thioamides and selemides controlled by MeNO2-H2O system. | Alpha-sulfanyl and alpha-selanyl propadienyl cations were easily generated by the catalytic system, scandium triflate-nitromethane-H(2)O in the presence of Bu(4)NHSO(4), to regioselectively afford the multifunctionalized thiazoles and selenazoles in high yields. | ['Catalysis', 'Cations', 'Cyclization', 'Mesylates', 'Molecular Structure', 'Organoselenium Compounds', 'Scandium', 'Stereoisomerism', 'Sulfhydryl Compounds', 'Thiazoles', 'Thioamides'] | 19,505,122 | [['G02.130'], ['D01.248.497.300'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.455.326.146.100.050.500', 'D02.886.645.600.055.050.510'], ['G02.111.570', 'G02.466'], ['D02.731'], ['D01.268.558.800', 'D01.268.956.827', 'D01.552.550.800'], ['G02.607.445.682'], ['D02.886.489'], ['D02.886.675', 'D03.383.129.708'], ['D0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Model predictive controller for biodegradable polyhydroxyalkanoate production in fed-batch culture. | The aim of this study is to develop a model predictive controller (MPC) accompanied with a metabolic reaction model controller for controlling ethanol and n-pentanol concentrations and the mole fraction of monomer units in the production of poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate), P(HB-co-HV), a biodegradabl... | ['Biodegradation, Environmental', 'Biosensing Techniques', 'Biotechnology', 'Ethanol', 'Feedback', 'Models, Biological', 'Pentanols', 'Polyesters'] | 11,911,925 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['E05.601.043'], ['H01.158.550', 'J01.897.120'], ['D02.033.375'], ['L01.906.394.211'], ['E05.599.395'], ['D02.033.415.640', 'D10.289.640'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
A glucocorticoid-inducible transcription system causes severe growth defects in Arabidopsis and induces defense-related genes. | A glucocorticoid-inducible transcription system was employed to control the expression of AtEBP, an Arabidopsis transcription factor. A number of the transgenic AtEBP lines had developmental and growth defects when grown on dexamethasone (DEX), a strong synthetic glucocorticoid. However, these growth defects were not c... | ['Arabidopsis', 'Base Sequence', 'DNA Primers', 'Dexamethasone', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Genetic Vectors', 'Glucocorticoids', 'Plants, Genetically Modified', 'Transcription Factors', 'Transcription, Genetic'] | 10,571,872 | [['B01.650.940.800.575.912.250.157.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.360.337'], ['D06.472.040.543... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evidence that the reversible MAO-A inhibitor moclobemide increases prolactin secretion by a serotonergic mechanism in healthy male volunteers. | The serotonin receptor antagonist methysergide was used to investigate the mechanism mediating stimulation of prolactin release after single doses of the reversible MAO-A inhibitor moclobemide. Eight healthy male volunteers participated in a placebo-controlled cross-over study, where pretreatment with methysergide almo... | ['Adult', 'Benzamides', 'Double-Blind Method', 'Growth Hormone', 'Humans', 'Kinetics', 'Male', 'Methoxyhydroxyphenylglycol', 'Methysergide', 'Moclobemide', 'Monoamine Oxidase Inhibitors', 'Prolactin', 'Random Allocation', 'Reference Values', 'Serotonin', 'Time Factors'] | 2,250,565 | [['M01.060.116'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D02.03... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The pathogenesis of abdominal aortic aneurysm and polymorphism of haptoglobin and inflammatory factor]. | 52 patients were operated on for abdominal aortic aneurysm and 38 for aortic occlusion disease. Haptoglobin (Hp) phenotypes were determined in all these patients. Hp and C-reactive protein (CRP) concentrations were determined in each phenotype. On the basis of the statistical analysis the highest percentage of elevated... | ['Aged', 'Alleles', 'Aortic Aneurysm, Abdominal', 'C-Reactive Protein', 'Female', 'Haptoglobins', 'Humans', 'Inflammation Mediators', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Retrospective Studies'] | 10,745,695 | [['M01.060.116.100'], ['G05.360.340.024.340.030'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['D12.776.124.050.300', 'D12.776.124.790.106.394', 'D12.776.377.715.085.394', 'D12.776.395.560.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subdental synchondrosis fracture in children: the value of 3-dimensional computerized tomography. | A case is presented illustrating the usefulness of computerized tomography (CT) with 3-dimensional (3-D) reconstruction for evaluation of a subdental synchondrosis fracture in a child. Odontoid fractures in children less than 7 years of age occur at the subdental synchondrosis and are typically diagnosed with plain x-r... | ['Child', 'Child, Preschool', 'Follow-Up Studies', 'Fracture Healing', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Odontoid Process', 'Spinal Fractures', 'Tomography, X-Ray Computed'] | 9,309,790 | [['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G16.762.891.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['A02.835.232.834.151.383.668'], ['C26.117.500.500', 'C26.404.812'], ['E01.370.350.350.810', 'E01.370.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in VLBW infants - a randomized, controlled trial. | BACKGROUND & AIMS: An anabolic state can be achieved upon intravenous amino acid administration during the immediate postnatal phase despite a low energy intake. The optimal dosing of amino acid and energy intake has yet to be established. The aim was to quantify the efficacy of early initiation of parenteral lipids an... | ['Amino Acids', 'Dietary Fats', 'Dose-Response Relationship, Drug', 'Emulsions', 'Energy Intake', 'Female', 'Fish Oils', 'Glucose', 'Humans', 'Infant Nutritional Physiological Phenomena', 'Infant, Newborn', 'Infant, Premature', 'Infant, Very Low Birth Weight', 'Keto Acids', 'Leucine', 'Male', 'Olive Oil', 'Parenteral N... | 24,461,877 | [['D12.125'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G07.690.773.875', 'G07.690.936.500'], ['D20.280.260', 'D26.255.165.260'], ['G07.203.650.240.340'], ['D10.627.430'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.220.500'], ['M01.060.703.520'], ['M01.060.703.520... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Death receptor 4 and bladder cancer risk. | Tumor necrosis factor-related apoptosis-inducing ligand stimulates the extrinsic apoptoticpathway by binding to death receptors 4 (DR4) and 5 (DR5). In DR4 exon 4, a C-->G polymorphism at amino acid 626 located immediately 3' to one of the main receptor ligand interface regions, results in a threonine-->arginine change... | ['Alleles', 'Case-Control Studies', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'Receptors, Tumor Necrosis Factor', 'Risk... | 12,649,168 | [['G05.360.340.024.340.030'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.393.620.500'], ['G05.365.795'], ['G05.365.795.595'], ['D12.776.543.750.690.600', '... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proteomic responses of carotenoid and retinol administration to Mongolian gerbils. | Various health benefits of carotenoids have been described. However, while human observational studies generally suggest positive health effects, supplementation with relatively high doses of individual carotenoids (supplements) have partly produced adverse effects. In the present study, we investigated the effect of s... | ['Adipose Tissue', 'Animals', 'Carotenoids', 'Chromatography, High Pressure Liquid', 'Gerbillinae', 'Liver', 'Lycopene', 'Male', 'Mass Spectrometry', 'Models, Animal', 'Proteins', 'Proteomics', 'Vitamin A'] | 29,951,678 | [['A10.165.114'], ['B01.050'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.992.635.300'], ['A03.620'], ['D02.455.326.271.665.202.216', 'D02.455.426.392.368.367.379.249.213', 'D02.455.849.131.216', 'D23.767.261.375']... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Information technology for patient safety. | BACKGROUND: Research on patient care has identified substantial variations in the quality and safety of healthcare and the considerable risks of iatrogenic harm as significant issues. These failings contribute to the high rates of potentially avoidable morbidity and mortality and to the rising levels of healthcare expe... | ['Adverse Drug Reaction Reporting Systems', 'Cost-Benefit Analysis', 'Developing Countries', 'Evidence-Based Medicine', 'Health Care Sector', 'Humans', 'Medical Informatics', 'Medication Errors', 'Patient Safety', 'Patient-Centered Care', 'Quality Assurance, Health Care', 'Telemedicine'] | 20,693,213 | [['E05.337.800.120', 'N02.421.668.320.120'], ['N03.219.151.125'], ['I01.615.500.300'], ['H02.249.750', 'H02.403.200.400'], ['J01.576.489', 'N03.219.650'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500'], ['E02.319.529', 'N02.421.450.500'], ['N06.850.135.060.075.399'], ['N04.590.233.727.407'], ['N04.761... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
Integrative subtype discovery in glioblastoma using iCluster. | Large-scale cancer genome projects, such as the Cancer Genome Atlas (TCGA) project, are comprehensive molecular characterization efforts to accelerate our understanding of cancer biology and the discovery of new therapeutic targets. The accumulating wealth of multidimensional data provides a new paradigm for important ... | ['Brain Neoplasms', 'Cluster Analysis', 'DNA Methylation', 'Databases, Factual', 'GTP-Binding Proteins', 'Gene Expression Profiling', 'Glioblastoma', 'Homeodomain Proteins', 'Humans', 'Kaplan-Meier Estimate', 'Neurofibromin 1', 'PTEN Phosphohydrolase', 'Promoter Regions, Genetic', 'Software'] | 22,539,962 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['E05.393.332'], ['... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
2004 update of dosimetry for the Utah Thyroid Cohort Study. | In the 1980s, individual thyroid doses and uncertainties were estimated for members of a cohort of children identified in 1965 in Utah and Nevada who had potentially been exposed to fallout from the Nevada Test Site. That reconstruction represented the first comprehensive assessment of doses received by the cohort and ... | ['Body Burden', 'Clinical Trials as Topic', 'Cohort Studies', 'Computer Simulation', 'Environmental Exposure', 'Humans', 'Models, Biological', 'Neoplasms, Radiation-Induced', 'Radiation Dosage', 'Radioactive Fallout', 'Radiometry', 'Relative Biological Effectiveness', 'Risk Assessment', 'Thyroid Neoplasms', 'Utah'] | 16,435,919 | [['E05.799.638.231', 'N06.850.460.200'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.224.160'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['C04.682', 'C26.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
alpha7 receptor-selective agonists and modes of alpha7 receptor activation. | The alpha7-selective agonists 3-(2, 4-dimethoxybenzylidene)-anabaseine (GTS-21), also known as DMXB, and 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) produce a variety of behavioral and cytoprotective effects that may be related to the activation of either large transient currents at high concentrations or... | ['Anabasine', 'Animals', 'Benzylidene Compounds', 'Bungarotoxins', 'Cell Survival', 'Dose-Response Relationship, Drug', 'Electrophysiology', 'Evaluation Studies as Topic', 'Hypothalamus', 'Kinetics', 'Neurons', 'Nicotinic Agonists', 'PC12 Cells', 'Pyridines', 'Rats', 'Receptors, Nicotinic', 'alpha7 Nicotinic Acetylchol... | 10,771,012 | [['D03.132.066', 'D03.383.621.050'], ['B01.050'], ['D02.455.426.559.389.150'], ['D20.888.850.325.139', 'D23.946.833.850.325.139'], ['G04.346'], ['G07.690.773.875', 'G07.690.936.500'], ['H01.158.344.528', 'H01.158.782.236'], ['E05.337', 'N05.715.360.335'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['G01.374.66... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003. | Respiratory viruses were identified by the polymerase chain reaction (PCR) in more than 4,200 specimens collected during 2002 and 2003 in Victoria, Australia from patients admitted to hospitals or participating in an influenza surveillance program. Influenza viruses and picornaviruses were important causes of morbidity... | ['Age Distribution', 'Bronchoalveolar Lavage Fluid', 'Female', 'Hospitalization', 'Humans', 'Male', 'Pleural Effusion', 'Polymerase Chain Reaction', 'Respiratory System', 'Respiratory Tract Infections', 'Retrospective Studies', 'Seasons', 'Sentinel Surveillance', 'Sputum', 'Victoria', 'Viruses'] | 15,543,580 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E05.927.100.500'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.652'], ['E05.393.620.500'], ['A04'], ['C01.748', 'C08.730'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', '... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The emergence of transcriptional identity in somatosensory neurons. | More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess th... | ['Animals', 'Female', 'Gene Expression Regulation, Developmental', 'Homeodomain Proteins', 'Mice', 'Nerve Growth Factor', 'Neurogenesis', 'Neurons', 'RNA', 'Single-Cell Analysis', 'Transcription Factor Brn-3B', 'Transcription Factor Brn-3C'] | 31,915,380 | [['B01.050'], ['G05.308.310'], ['D12.776.260.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.644.276.860.437', 'D12.776.467.860.437', 'D12.776.631.600.437', 'D23.529.850.437'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['A08.675', 'A11.671'], ['D13.444.735'], ['E05.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative bio-availability of theophylline whole and halved sustained-release tablets. | In a randomised, multiple-dose, cross-over study in 14 healthy volunteers, plasma theophylline concentrations were compared during a 12-hour dosing interval after repeated administration of theophylline (Euphyllin Retard; Byk Gulden) as whole and halved tablets. Bio-availability of theophylline from the halved tablets ... | ['Adult', 'Biological Availability', 'Clinical Trials as Topic', 'Delayed-Action Preparations', 'Humans', 'Male', 'Random Allocation', 'Tablets', 'Theophylline', 'Time Factors'] | 3,299,763 | [['M01.060.116'], ['G03.787.151', 'G07.690.725.129'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D26.255.210', 'E02.319.300.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['D26.255.830'],... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The "Preflow technic", a new method of pharmacoradiography of the mesenteric area]. | In 16 dog experiments we were able to demonstrate that the conventional selective angiography of the superior mesenteric artery (sma) is performed in a status of underperfusion. By the injection of 50% glucose in a well defined time interval preceding the application of the contrast medium an increase of blood flow can... | ['Angiography', 'Animals', 'Dogs', 'Glucose', 'Hemodynamics', 'Mesenteric Arteries', 'Regional Blood Flow'] | 1,207,257 | [['E01.370.350.700.060', 'E01.370.370.050'], ['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['D09.947.875.359.448'], ['G09.330.380'], ['A07.015.114.565'], ['G09.330.100.780']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of glucose concentration on the reciprocal regulation of rRNA promoters in Plasmodium falciparum. | The developmental progression of Plasmodium falciparum is remarkably sensitive to glucose concentration. We have investigated the effects of glucose concentration on the parasite development cycle as reflected by changes of ribosomal RNA (rRNA) transcription. We showed that glucose starvation differentially affects tra... | ['Animals', 'Base Sequence', 'Cold Temperature', 'Conserved Sequence', 'Glucose', 'Kinetics', 'Molecular Sequence Data', 'Plasmodium falciparum', 'Promoter Regions, Genetic', 'RNA, Protozoan', 'RNA, Ribosomal', 'Sequence Alignment', 'Sequence Homology, Nucleic Acid', 'Transcription, Genetic'] | 14,570,919 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G02.111.570.580'], ['D09.947.875.359.448'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['B01.043.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections. | A number of human brain diseases have been associated with disturbances in the structure and function of cortical synapses. Answering fundamental questions about the synaptic machinery in these disease states requires the ability to image and quantify small synaptic structures in tissue sections and to evaluate protein... | ['Animals', 'Brain', 'Imaging, Three-Dimensional', 'Macaca fascicularis', 'Male', 'Microscopy, Confocal', 'Microscopy, Fluorescence', 'Synapses'] | 18,793,619 | [['B01.050'], ['A08.186.211'], ['E01.370.350.400', 'L01.224.308.410'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.458', 'E05.595.458'], ['A08.850', 'A11.284.149.165.420.780']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Retroperitoneal arteriovenous malformation, a rare cause of heart failure in infancy: consideration of therapeutic approaches. | We report an infant presenting with congestive heart failure secondary to a large retroperitoneal arteriovenous (AV) malformation. The heart failure was treated by catheter embolization of the feeding arterial vessels with Ivalon particles. Following resolution of the heart failure, a residual avascular mass remained. ... | ['Antineoplastic Combined Chemotherapy Protocols', 'Arteriovenous Malformations', 'Combined Modality Therapy', 'Embolization, Therapeutic', 'Female', 'Heart Failure', 'Humans', 'Infant', 'Polyvinyls', 'Retroperitoneal Neoplasms', 'Retroperitoneal Space', 'Sarcoma'] | 8,456,024 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C14.240.850.750', 'C14.907.150', 'C16.131.240.850.750'], ['E02.186'], ['E02.520.360', 'E02.926.500'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D02.455.326.271.665.616', 'D02.455.326.271.884.533', 'D05.750.716.721',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Lipase-catalyzed biodiesel production from waste activated bleaching earth as raw material in a pilot plant. | The production of fatty acid methyl esters (FAMEs) from waste activated bleaching earth (ABE) discarded by the crude oil refining industry using lipase from Candida cylindracea was investigated in a 50-L pilot plant. Diesel oil or kerosene was used as an organic solvent for the transesterification of triglycerides embe... | ['Candida', 'Carbon Monoxide', 'Earth, Planet', 'Fungal Proteins', 'Gasoline', 'Industrial Waste', 'Kerosene', 'Lipase', 'Pilot Projects', 'Sulfur Dioxide'] | 17,629,478 | [['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['G01.060.075.730.700.200'], ['D12.776.354'], ['D20.345.630.540', 'N06.230.132.258.630.540'], ['D20.944.420', 'N06.850.460.710.420'], ['D20.345.630.600', 'N06.230.132.258.630.600'], ['D08.811.277.352.100.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. | The nature and properties of the T4-binding albumins in the sera of normal subjects and patients with the syndrome of familial dysalbuminemic hyperthyroxinemia (FDH) were investigated by means of isoelectric focusing in polyacrylamide gels. Albumins isolated from normal sera and sera of patients with FDH displayed mult... | ['Alkylation', 'Dithiothreitol', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Isoelectric Focusing', 'Oxidation-Reduction', 'Protein Binding', 'Serum Albumin', 'Sulfhydryl Compounds', 'Thyroxine', 'Thyroxine-Binding Proteins'] | 3,919,043 | [['G02.111.035', 'G02.607.094', 'G03.059'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.401.663', 'E05.301.300.663'], ['G02.700', 'G03.295.531'], ['G02.111.679', 'G03.808'], ['D12.776.034.841', 'D12.776.124.727... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? | OBJECTIVE: The worldwide prevalence of congenital rubella syndrome has drastically decreased after the uptake of vaccine to prevent the infection. However, outbreaks have occurred in some countries due to their own vaccination policies, and this phenomenon has not yet been investigated in Taiwan. Our study aims to fill... | ['Adolescent', 'Adult', 'Antibodies, Viral', 'Child', 'Child, Preschool', 'Disease Susceptibility', 'Humans', 'Immunization Programs', 'Infant', 'Prevalence', 'Retrospective Studies', 'Rubella Syndrome, Congenital', 'Rubella virus', 'Seroepidemiologic Studies', 'Taiwan', 'Young Adult'] | 27,343,317 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.687', 'G07.100.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['M01.060.703'], ['E05.318.308.985.525.750', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Fatty acid synthase is a novel therapeutic target in multiple myeloma. | This study investigated the biological significance of the inhibition of fatty acid synthase (FAS) in multiple myeloma (MM) using the small molecule inhibitor Cerulenin. Cerulenin triggered growth inhibition in both MM cell lines and MM patient cells, and overcame the survival and growth advantages conferred by interle... | ['Antineoplastic Combined Chemotherapy Protocols', 'Apoptosis', 'Caspase 3', 'Caspase 8', 'Caspase 9', 'Cell Line, Tumor', 'Cerulenin', 'Drug Delivery Systems', 'Drug Evaluation', 'Enzyme Activation', 'Fatty Acid Synthases', 'Humans', 'JNK Mitogen-Activated Protein Kinases', 'MAP Kinase Kinase 4', 'Multiple Myeloma', '... | 18,410,446 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.550.800', 'D08.811.277.656.300.200.126.550.800', 'D12.644.360.024.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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