Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cannabinoids in exhaled breath following controlled administration of smoked cannabis. | BACKGROUND: Ä(9)-Tetrahydrocannabinol (THC), 11-nor-9-carboxy-THC (THCCOOH), and cannabinol (CBN) were measured in breath following controlled cannabis smoking to characterize the time course and windows of detection of breath cannabinoids.METHODS: Exhaled breath was collected from chronic (?4 times per week) and occas... | ['Adult', 'Breath Tests', 'Cannabinoids', 'Cannabis', 'Chromatography, Liquid', 'Female', 'Humans', 'Limit of Detection', 'Male', 'Marijuana Smoking', 'Tandem Mass Spectrometry', 'Young Adult'] | 24,046,200 | [['M01.060.116'], ['E01.370.100'], ['D02.455.849.090'], ['B01.650.940.800.575.912.250.859.937.055.500'], ['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['F01.145.610.875', 'F01.145.805.250.500'], ['E05.196.566.880'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structure of the female cephalic end and cuticular ornamentations of Buckleyella buckleyi Rasheed, 1963 (Nematoda: Philometridae), as revealed by SEM. | Light and scanning electron microscopical examination of gravid females of the philometrid nematode Buckleyella buckleyi Rasheed, 1963 from the original material, collected by Rasheed from the mesentery of the type host (marine fish) Scomberoides tala off Pakistan in 1961, revealed the presence of a mound, surrounding ... | ['Animals', 'Dracunculoidea', 'Female', 'Fish Diseases', 'Microscopy, Electron, Scanning', 'Perciformes', 'Spirurida Infections'] | 20,557,216 | [['B01.050'], ['B01.050.500.500.294.400.937.225.250'], ['C22.362'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['B01.050.150.900.493.602'], ['C01.610.335.508.700.750']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fundamental equation of thermodynamics for protein-ligand binding. | For the internal energy and every thermodynamic potential that can be defined by a Legendre transform, there is a fundamental equation that contains all the thermodynamic information about a system. For a system involving the binding of molecular oxygen and hydrogen ions by a protein, fundamental equations are given fo... | ['Algorithms', 'Hydrogen', 'Hydrogen-Ion Concentration', 'Models, Chemical', 'Oxygen', 'Protein Binding', 'Proteins', 'Temperature', 'Thermodynamics'] | 12,914,902 | [['G17.035', 'L01.224.050'], ['D01.268.406', 'D01.362.340'], ['G02.300'], ['E05.599.495'], ['D01.268.185.550', 'D01.362.670'], ['G02.111.679', 'G03.808'], ['D12.776'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.906']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Use of Simple Telemetry to Reduce the Health Impacts of Fuel Poverty and Living in Cold Homes. | INTRODUCTION: In Great Britain, roughly half of people with at least one long-standing illness (LSI) live in low-income households. Lower-income households are at risk of fuel poverty and living in a colder house, which can worsen certain health conditions, causing related morbidity and mortality. This pilot study aime... | ['Cold Temperature', 'Electric Power Supplies', 'Family Characteristics', 'Health Status', 'Humans', 'Morbidity', 'Pilot Projects', 'Poverty', 'Seasons', 'Surveys and Questionnaires', 'Telemetry', 'United Kingdom'] | 31,405,064 | [['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E07.305.124'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425']... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Coronary artery thrombus: rapid resolution shown by serial coronary arteriography. | Resolution of a coronary artery thrombus within two weeks was demonstrated by serial coronary arteriography in a man with atherosclerotic coronary artery disease. This observation indicates that subtotal coronary artery thrombosis does not invariably progress to complete occlusion of the affected vessel and that the re... | ['Aged', 'Coronary Angiography', 'Coronary Disease', 'Humans', 'Male'] | 7,244,758 | [['M01.060.116.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tolerance to the reinforcing effects of cocaine in a progressive ratio paradigm. | This experiment used rats to test whether a regimen of chronic cocaine would produce tolerance to cocaine i.v. self-administration under a progressive ratio (PR) schedule of reinforcement. Under this PR schedule, an increasing number of responses was required to complete the ratio for each subsequent cocaine injection,... | ['Animals', 'Cocaine', 'Conditioning, Operant', 'Dose-Response Relationship, Drug', 'Drug Tolerance', 'Injections, Intravenous', 'Male', 'Rats', 'Rats, Inbred F344', 'Reinforcement Schedule', 'Reinforcement, Psychology', 'Self Administration'] | 7,892,423 | [['B01.050'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['F02.463.425.179.509'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.992'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laparoscopic ureterolithotomy: our experience with 74 cases. | OBJECTIVES: We retrospectively evaluated our experience with a relatively uncommon procedure, the laparoscopic ureterolithotomy, for the treatment of ureteral stones.METHODS: Between April 2002 and October 2006, a total of 74 patients (56 males, 18 females) with upper (54 cases), middle (18 cases) and lower (two cases)... | ['Adult', 'Aged', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Retrospective Studies', 'Ureteral Calculi', 'Urologic Surgical Procedures', 'Young Adult'] | 18,479,354 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.50... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Oral bioavailability of clonidine in children. | BACKGROUND: Oral clonidine is used as premedication in children. The bioavailability of clonidine given orally in adults is 75-100% but is unknown in children.METHODS: Children (3-10 years) undergoing adenotonsillectomy were administered oral clonidine 4 mcg·kg(-1) mixed with apple fruit drink as premedication. Intrave... | ['Administration, Oral', 'Adrenergic alpha-Agonists', 'Algorithms', 'Analysis of Variance', 'Anesthesia, General', 'Anesthesia, Intravenous', 'Biological Availability', 'Child', 'Child, Preschool', 'Chromatography, High Pressure Liquid', 'Clonidine', 'Female', 'Hemodynamics', 'Humans', 'Injections, Intravenous', 'Intes... | 20,735,802 | [['E02.319.267.100'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['G17.035', 'L01.224.050'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E03.155.197'], ['E03.155.308'], ['G03.787.151', 'G07.690.725.129'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.181.400.300'], ['D03.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
3D MALDI Mass Spectrometry Imaging of a Single Cell: Spatial Mapping of Lipids in the Embryonic Development of Zebrafish. | The zebrafish (Danio rerio) has been widely used as a model vertebrate system to study lipid metabolism, the roles of lipids in diseases, and lipid dynamics in embryonic development. Here, we applied high-spatial resolution matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) to map and v... | ['Animals', 'Embryo, Nonmammalian', 'Imaging, Three-Dimensional', 'Phospholipids', 'Single-Cell Analysis', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Zebrafish'] | 29,097,697 | [['B01.050'], ['A13.350', 'A16.331'], ['E01.370.350.400', 'L01.224.308.410'], ['D10.570.755'], ['E05.242.900'], ['E05.196.566.755'], ['B01.050.150.900.493.200.244.828']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hemodynamic changes in patients developing effective hypovolemia after total paracentesis. | BACKGROUND/AIMS: In many centers paracentesis is considered the treatment of choice for tense ascites. However, the mechanism of effective hypovolemia after paracentesis, the main complication associated with this procedure, remains unknown. In the current study, systemic hemodynamics was sequentially studied before an... | ['Adult', 'Aged', 'Aldosterone', 'Analysis of Variance', 'Ascites', 'Blood Pressure', 'Blood Volume', 'Cardiac Output', 'Female', 'Hemodynamics', 'Humans', 'Linear Models', 'Liver Cirrhosis', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Paracentesis', 'Renin', 'Vascular Resistance'] | 9,566,833 | [['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C23.550.081'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.188.130', 'G09.330.380.092'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G09.330.380... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Application of Reporter Gene Labeling in Stem Cell Therapy for Acute Myocardial Infarction]. | Stem cell therapy for acute myocardial infarction is drawing great attention. However,the biological behavior and function mechanism of implanted stem cells remain controversial, as well as their clinical benefits. With the development of imaging probes and devices, molecular imaging enables noninvasive, dynamic tracki... | ['Genes, Reporter', 'Genetic Therapy', 'Humans', 'Myocardial Infarction', 'Stem Cell Transplantation'] | 26,564,517 | [['G05.360.340.024.340.435'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E02.095.147.500.500', 'E04.936.225.687']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region. | A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning pr... | ['Animals', 'Gene Expression Regulation', 'Hippocampus', 'In Situ Hybridization', 'Learning', 'Long-Term Potentiation', 'Male', 'Memory', 'Neuronal Plasticity', 'Oligonucleotide Array Sequence Analysis', 'RNA, Messenger', 'RNA, Small Interfering', 'Rats', 'Rats, Long-Evans', 'Temporal Lobe'] | 18,650,386 | [['B01.050'], ['G05.308'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['F02.463.425', 'F02.784.629.529'], ['G11.561.638.350'], ['F02.463.425.540'], ['G11.561.638'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exonuclease III-boosted cascade reactions for ultrasensitive SERS detection of nucleic acids. | A variety of nucleic acid amplification techniques have been integrated into different detection methods to promote the development of sensitive and convenient analysis of nucleic acids. However, it is still in urgent need to develop amplified nucleic acid biosensors for the analysis of susceptible gene and even distin... | ['Biosensing Techniques', 'Exodeoxyribonucleases', 'G-Quadruplexes', 'Limit of Detection', 'Nucleic Acid Amplification Techniques', 'Nucleic Acid Hybridization', 'Nucleic Acids', 'Spectrum Analysis, Raman'] | 29,306,030 | [['E05.601.043'], ['D08.811.277.352.335.375', 'D08.811.277.352.365.290'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.393.620'], ['E05.393.661', 'G02.111.611'], ['D13.444'], ['E05.196.822.860', 'E05.196.867.890']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Screening for kidney diseases in children]. | Screening tests have come to be useful in present-day pediatrics. Implementation of the screening is aimed at improving the health status of populations, finding it out by death rates as well as by physical and emotional state of those patients having been early diagnosed. Overall 846 children with different urogenital... | ['Biomarkers', 'Child', 'Child, Preschool', 'Humans', 'Kidney Diseases', 'Mass Screening'] | 11,455,927 | [['D23.101'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stimulation of ornithine decarboxylase activity in digestive tract mucosa. | Refeeding fasted rats with normal rat food and with a variety of amino acids increases ornithine decarboxylase (ODC) activity considerably. The time course of that increase, the areas of the digestive tract directly affected, and the effective concentrations of stimulants are unknown. By use of isolated 5-cm segments o... | ['Alanine', 'Animals', 'Fasting', 'Glucose', 'Glycine', 'Intestinal Mucosa', 'Jejunum', 'Male', 'Ornithine Decarboxylase', 'Osmolar Concentration', 'Rats', 'Rats, Inbred Strains', 'Sodium Chloride', 'Stimulation, Chemical', 'Water'] | 3,631,267 | [['D12.125.042'], ['B01.050'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['D09.947.875.359.448'], ['D12.125.481'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684.500', 'A03.556.249.750'], ['D08.811.520.224.125.425'], ['G02.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. | Proteins of the presynaptic exocytic machinery have been found associated with the acrosome of male germ cells, suggesting that the sperm acrosome reaction and neurotransmission at chemical synapses may share some common mechanisms. To substantiate this hypothesis, we studied the expression and ultrastructural localiza... | ['Acrosome', 'Amino Acid Transport Systems', 'Animals', 'Brain', 'Calcium-Binding Proteins', 'Carrier Proteins', 'Immunohistochemistry', 'Male', 'Microscopy, Immunoelectron', 'Rats', 'Rats, Wistar', 'Synapses', 'Testis'] | 12,754,292 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['D12.776.157.530.200', 'D12.776.543.585.200'], ['B01.050'], ['A08.186.211'], ['D12.776.157.125'], ['D12.776.157'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.58... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Ascites and abdominal pseudocyst: two uncommon ventriculoperitoneal shunt complications in two cases. | Ascites and abdominal pseudocysts (APC) are two rare complications that can occur following placement of a ventriculoperitoneal (VP) shunt. Both complications are characterized by abnormal intraperitoneal cerebrospinal fluid (CSF) collections. Although various factors have been implicated, the exact pathogenesis of the... | ['Abdomen', 'Ascites', 'Child', 'Cysts', 'Equipment Failure', 'Female', 'Humans', 'Hydrocephalus', 'Male', 'Ventriculoperitoneal Shunt'] | 24,577,989 | [['A01.923.047'], ['C23.550.081'], ['M01.060.406'], ['C04.182', 'C23.300.306'], ['E05.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602'], ['E04.035.188.850', 'E04.525.170.850']] | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Acute rupture of anterior cruciate ligament: diagnosis and treatment by early arthroscopy]. | OBJECTIVE: To early diagnose and treat acute rupture of anterior cruciate ligament (ACL).METHODS: 23 patients with acute rupture of ACL were examined and treated by early arthroscopy.RESULTS: The preoperative diagnosis of ACL rupture was similar to that of in 18 patients. Three patients were confirmed by early arthrosc... | ['Acute Disease', 'Adolescent', 'Adult', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Injuries', 'Arthroscopy', 'Female', 'Humans', 'Knee Injuries', 'Male', 'Middle Aged', 'Rupture'] | 11,829,923 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['C26.558.554.213'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['M01.060.116.630'], ['C26.761']] | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Accelerated idioventricular rhythm. 2 new cases in children]. | Two new cases of idiopathic accelerated idioventricular rhythm are reported in children aged 12 and 16. This is a very rare arrhythmia in childhood with only 12 previously published cases in the medical literature. The prognosis seems to be excellent in all cases which underlines the importance of distinguishing this r... | ['Adolescent', 'Arrhythmias, Cardiac', 'Child', 'Chronic Disease', 'Diagnosis, Differential', 'Electrocardiography', 'Humans', 'Male', 'Prognosis'] | 3,925,922 | [['M01.060.057'], ['C14.280.067', 'C23.550.073'], ['M01.060.406'], ['C23.550.291.500'], ['E01.171'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Document management systems to support quality management systems at university hospitals - an interview-based study]. | In order to save and control the processes and quality of medical services, a suitable steering system of all relevant documents is essential from the point of view of clinical quality management. Systems supporting an automated steering system of documents are called document management systems (DMS), and they also en... | ['Data Accuracy', 'Delivery of Health Care', 'Germany', 'Hospitals, University', 'Humans', 'Patient Safety', 'Process Assessment, Health Care', 'Total Quality Management'] | 29,655,933 | [['E05.318.308.028', 'E05.318.370.725.250', 'L01.399.250.202', 'N05.715.360.300.202', 'N05.715.360.325.685.250'], ['N04.590.374', 'N05.300'], ['Z01.542.315'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.135.060.075.399'], ['N04.761.559.650', 'N05.715.360.57... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial. | BACKGROUND: We have recently provided preliminary clinical observations indicating that memantine, as augmenting agent, was associated with a meaningful antimanic and mood-stabilizing effect in treatment-resistant bipolar disorders. To further investigate the therapeutic and prophylactic action of the drug we administe... | ['Adult', 'Affect', 'Aged', 'Aged, 80 and over', 'Antidepressive Agents', 'Antimanic Agents', 'Bipolar Disorder', 'Excitatory Amino Acid Antagonists', 'Female', 'Humans', 'Male', 'Memantine', 'Middle Aged', 'Receptors, N-Methyl-D-Aspartate', 'Young Adult'] | 22,030,128 | [['M01.060.116'], ['F01.470.047'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.427.700.122'], ['D27.505.696.277.950.025', 'D27.505.954.427.210.950.025', 'D27.505.954.427.700.872.025'], ['F03.084.500'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The incidence and significance of emesis associated with out-of-hospital cardiac arrest. | STUDY OBJECTIVE: Studies have suggested that emesis may occur in up to a third of cardiac arrest patients. The goal of this investigation was to characterize the frequency, timing, and outcome association of emesis in persons suffering out-of-hospital cardiac arrest in order to understand the role and care-implications... | ['Aged', 'Cardiopulmonary Resuscitation', 'Emergency Medical Technicians', 'Female', 'Follow-Up Studies', 'Heart Arrest', 'Hospitalization', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Odds Ratio', 'Outpatients', 'Retrospective Studies', 'Survival Rate', 'United States', 'Vomiting'] | 17,433,526 | [['M01.060.116.100'], ['E02.365.647.110'], ['M01.526.373.250', 'M01.526.485.067.150', 'N02.360.067.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C14.280.383'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of low doses of clonidine in the monkey cranial circulation. | Migraine therapy using low doses of clonidine has been based on the proposal that clonidine directly inhibits vascular smooth muscle reactivity. In anaesthetized monkeys in which internal and external carotid vascular resistances were measured, the only significant effects of clonidine administered acutely (0.5 and 2 m... | ['Animals', 'Blood Pressure', 'Cerebrovascular Circulation', 'Clonidine', 'Dose-Response Relationship, Drug', 'Histamine', 'Macaca nemestrina', 'Migraine Disorders', 'Norepinephrine', 'Sympathetic Nervous System', 'Vascular Resistance'] | 7,202,484 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.100.159'], ['D03.383.129.308.436.500'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['B01.050.150.900.649.313.988.400.112.199.120.510.560'], ['C10.228.140.546.399.750'], ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of breathing exercises during the second stage of labor on labor pain and duration: a randomized controlled trial. | BACKGROUND: Some research exists on the effect of non-pharmacological approaches for labor pain relief. However, there is limited information about effectiveness of breathing exercises in pregnant women to reduce maternal pain during labor.OBJECTIVE: To determine whether breathing exercises for pregnant women during th... | ['Adult', 'Apgar Score', 'Breathing Exercises', 'Delivery, Obstetric', 'Female', 'Humans', 'Labor Pain', 'Pain Management', 'Pain Measurement', 'Pregnancy', 'Respiration', 'Treatment Outcome', 'Young Adult'] | 29,103,415 | [['M01.060.116'], ['E01.370.600.050'], ['E02.190.525.186', 'E02.779.474.124'], ['E04.520.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.451'], ['E02.745', 'N04.590.607.500'], ['E01.370.600.550.324'], ['G08.686.784.769'], ['G09.772.705'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Delayed autoimmune hemolytic anemia in efalizumab-treated psoriasis. | Efalizumab, a humanized anti-CD11a monoclonal antibody, has been shown to treat plaque psoriasis. A known association between this drug and autoimmune thrombocytopenia has already been established. More recently publicized, however, is efalizumab's ability to affect another cell line--that of the erythrocyte--and cause... | ['Anemia, Hemolytic, Autoimmune', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Cell Migration Inhibition', 'Humans', 'Male', 'Middle Aged', 'Psoriasis'] | 18,328,597 | [['C15.378.071.141.125', 'C20.111.175'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['G04.198.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.1... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Perigraft hemorrhage after abdominal aortic aneurysm repair in a heart transplant patient. | Spontaneous perigraft hemorrhage can occur years after a successful aortic aneurysm repair. Such hemorrhage can result, in part, from inadequate graft healing. Herein, we describe the case of a heart transplant recipient who underwent an abdominal aortic aneurysm repair that was complicated by an acute perigraft leak 6... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Aortography', 'Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Heart Transplantation', 'Humans', 'Immunosuppressive Agents', 'Male', 'Polyethylene Terephthalates', 'Postoperative Hemorrhage', 'Prosthesis Design', 'Reoperation', 'Suture Techniques', 'Time Factor... | 20,978,572 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['D05.75... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Ibrutinib-related bleeding: pathogenesis, clinical implications and management. | : Ibrutinib is the first drug of a new family of Bruton's tyrosine kinases (Btk)-inhibiting agents, which have proved to be useful for the treatment of several B-cell lymphoid malignancies. This drug is associated to an increased bleeding risk from initial clinical trials especially in association with warfarin. Althou... | ['Agammaglobulinaemia Tyrosine Kinase', 'Anticoagulants', 'Blood Platelets', 'Drug Interactions', 'Hemorrhage', 'Humans', 'Platelet Activation', 'Platelet Aggregation Inhibitors', 'Protein Kinase Inhibitors', 'Protein-Tyrosine Kinases', 'Pyrazoles', 'Pyrimidines'] | 29,995,658 | [['D08.811.913.696.620.682.725.025'], ['D27.505.954.502.119'], ['A11.118.188', 'A15.145.229.188'], ['G07.690.773.968'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.188.390.600'], ['D27.505.954.502.780'], ['D27.505.519.389.755'], ['D08.811.913.696.620.682.725'], ['D03.383.129.539'], ['D03.383... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection. | In the last decade, a new gene family encoding non-rearranging receptors, called novel immune-type receptors (NITRs), has been discovered in teleost fish. NITRs belong to the immunoglobulin superfamily and represent an extraordinarily divergent and rapidly evolving gene complex. Genomic analysis of a region spanning 27... | ['Amino Acid Sequence', 'Animals', 'Bass', 'Chromosome Mapping', 'Fish Proteins', 'Gene Duplication', 'Gene Expression Profiling', 'Genetic Variation', 'Models, Molecular', 'Molecular Sequence Data', 'Multigene Family', 'Oryzias', 'Phylogeny', 'Protein Conformation', 'Protein Multimerization', 'Protein Structure, Terti... | 19,851,764 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.493.602.105'], ['E05.393.183'], ['D12.776.325'], ['G05.365.590.320', 'G05.558.320'], ['E05.393.332'], ['G05.365'], ['E05.599.595'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['B01.050.150.900.493.850.139.650'], ['G05.697', 'G16.075.605'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Case of breast cancer with cartilage-like structure]. | A case of breast cancer with cartilage-like structure is presented. The stroma, resembling cartilagenous martrix upon hematoxylin and eosin staining, showed metachromasia upon toluidine blue staining. However, predigestion with hyaluronidase or chondroitinase ABC revealed no change in toluidine blue (pH 2.5) staining, ... | ['Breast Neoplasms', 'Carcinoma', 'Cartilage', 'Female', 'Humans', 'Mastectomy', 'Middle Aged'] | 6,663,716 | [['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['A02.165', 'A10.165.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.466'], ['M01.060.116.630']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparing infant oral glucose clearance with and without a water rinse. | The purpose of this study was to test the hypothesis that a small rinse of water in an infant's mouth immediately following formula consumption would significantly improve oral glucose clearance. Though statistically significant results were not obtained at all time intervals, this study lends validity to the hypothesi... | ['Dietary Carbohydrates', 'Glucose', 'Humans', 'Infant', 'Infant Food', 'Metabolic Clearance Rate', 'Mouthwashes', 'Saliva', 'Water'] | 15,354,382 | [['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G07.203.300.525.500', 'J02.500.525.500'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['D25.583', 'D27.720.102.583', 'D27.720.269.583', 'J01.6... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae. | In order to identify a protein interacting with RCC1, a guanine nucleotide-exchange factor for the nuclear GTPase Ran, we isolated a series of cold-sensitive suppressors of mtr1-2, a temperature-sensitive mutant of the Saccharomyces cerevisiae RCC1 homologue. One of the isolated suppressor mutants was mutated in the pu... | ['Base Sequence', 'Cell Cycle Proteins', 'DNA Primers', 'DNA-Binding Proteins', 'Fungal Proteins', 'GTP Phosphohydrolases', 'Gene Deletion', 'Genes, Fungal', 'Genes, Suppressor', 'Guanine Nucleotide Exchange Factors', 'Mutation', 'Nuclear Proteins', 'Saccharomyces cerevisiae', 'Temperature', 'ran GTP-Binding Protein'] | 8,886,981 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.167'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D12.776.260'], ['D12.776.354'], ['D08.811.277.040.330'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Effects of the steric hindrance of micropores in the hyper-cross-linked polymeric adsorbent on the adsorption of p-nitroaniline in aqueous solution. | A hyper-cross-linked polymeric adsorbent with "--CH2--phenol--CH2--" as the cross-linked bridge (denoted GQ-05), and another hyper-cross-linked polymeric adsorbent with "--CH2--p-cresol--CH2--" as the cross-linked bridge (denoted GQ-03) were synthesized to reveal the effect of the steric hindrance of micropores in the ... | ['Adsorption', 'Aniline Compounds', 'Kinetics', 'Polymers', 'Thermodynamics', 'Water Pollutants, Chemical'] | 25,136,766 | [['G01.030', 'G02.020'], ['D02.092.146'], ['G01.374.661', 'G02.111.490'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.906'], ['D27.888.284.903.655']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue. | Defects in the 20S/26S proteasome and conformational changes in alpha-synuclein (alpha-syn) are implicated in the development of sporadic and familial cases of PD. The objective of this study was to evaluate whether alpha-syn affects proteolysis by the proteasome and, reciprocally, whether proteasome inhibition affects... | ['Animals', 'Brain', 'Cell Line, Transformed', 'Cell Line, Tumor', 'Culture Media, Serum-Free', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Gene Expression Regulation', 'Humans', 'Indoles', 'Intermediate Filament Proteins', 'Mice', 'Mice, Transgenic', 'Mutation', 'Neural Inhibition', 'Neuroblastoma', 'Neu... | 19,653,055 | [['B01.050'], ['A08.186.211'], ['A11.251.210.172'], ['A11.251.210.190', 'A11.251.860.180'], ['D27.720.470.305.255', 'E07.206.255'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['D05.750.078.593', 'D12.776.220.475'], ['B0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crystallinity of lyophilised carrot cell wall components. | The aim of this work was to investigate the effect of removal of cell wall components on the crystallinity of cell walls using X-ray diffraction. Various insoluble cell wall residues were prepared following a sequential extraction of carrot cell wall material. X-ray diffraction patterns were typical of cellulose althou... | ['Borohydrides', 'Buffers', 'Carbonates', 'Cell Wall', 'Cellulose', 'Daucus carota', 'Edetic Acid', 'Hydroxides', 'Phenol', 'Polysaccharides', 'Potassium Compounds', 'Sodium Dodecyl Sulfate', 'X-Ray Diffraction'] | 10,628,533 | [['D01.132.105.050', 'D02.203.087.050'], ['D27.720.470.280'], ['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['A11.284.183'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['B01.650.940.800.575.912.250.075.278'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'],... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
PCR-based positive hybridization to detect genomic diversity associated with bacterial secondary metabolism. | A PCR-based positive hybridization (PPH) method was developed to explore toxic-specific genes in common between toxigenic strains of Anabaena circinalis, a cyanobacterium able to produce saxitoxin (STX). The PPH technique is based on the same principles of suppression subtractive hybridization (SSH), although with the ... | ['Anabaena', 'Bacterial Toxins', 'Gene Transfer, Horizontal', 'Genetic Variation', 'Genome, Bacterial', 'Genomic Library', 'Genomics', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Oligonucleotide Array Sequence Analysis', 'Phylogeny', 'Polymerase Chain Reaction', 'Reproducibility of Results', 'Saxitoxin'] | 14,718,552 | [['B03.280.100', 'B03.440.475.100.100', 'B03.585.051'], ['D23.946.123'], ['G05.728.390'], ['G05.365'], ['G05.360.340.358.207'], ['G05.360.325.425', 'G05.360.340.425'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['L01.453.245.667'], ['E05.393.661', 'G02.111.611'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response. | Bilirubin has been recognized as a powerful cytoprotectant when used at physiologic doses and was recently shown to have immunomodulatory effects in islet allograft transplantation, conveying donor-specific tolerance in a murine model. We hypothesized that bilirubin, an antioxidant, acts to suppress the innate immune r... | ['Animals', 'Bilirubin', 'Cell Survival', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Flow Cytometry', 'HMGB1 Protein', 'Immune Tolerance', 'Immunity, Innate', 'Immunoassay', 'Islets of Langerhans Transplantation', 'Mice'] | 27,393,133 | [['B01.050'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['G04.346'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.60... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bone mineral density and mammographic density in Mexican women. | BACKGROUND: Bone mineral density (BMD) is a putative marker for lifetime exposure to estrogen. Studies that have explored whether BMD is a determinant of mammographic density (MD) have observed inconsistent results. Therefore,we examined this potential association in a sample of women (n = 1,516) from the clinical sub-... | ['Adult', 'Body Mass Index', 'Bone Density', 'Breast', 'Breast Density', 'Breast Neoplasms', 'Estrogens', 'Female', 'Humans', 'Mammary Glands, Human', 'Mammography', 'Mexico', 'Middle Aged', 'Premenopause', 'Risk Factors'] | 26,463,740 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G11.427.100'], ['A01.236'], ['E01.370.600.115.275', 'G07.100.138'], ['C04.588.180', 'C17.800.090.500'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.236.249', 'A10.336... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Lipidome of plasma lipoproteins and liver is zinc- modulated in High fat diet treated mice. | Zinc (Zn) and Zn-transcription Factors regulate the metabolic pathways of lipids and glucose, consequently nutritional zinc deficiency or excess, activates stress pathways and deranges the hepatic metabolism of lipids. High fat diet (HFD) also leads to lipids' profile disorders as well as to intracellular free radicals... | ['Animals', 'Diet, High-Fat', 'Lipids', 'Lipoproteins', 'Liver', 'Magnetic Resonance Spectroscopy', 'Male', 'Mice', 'Zinc'] | 30,262,290 | [['B01.050'], ['G07.203.650.240.267'], ['D10'], ['D10.532', 'D12.776.521'], ['A03.620'], ['E05.196.867.519'], ['B01.050.150.900.649.313.992.635.505.500'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Double-blind randomized clinical trial of self-administered podofilox solution versus vehicle in the treatment of genital warts. | PURPOSE: Genital warts are a highly prevalent and chronic sexually transmitted disease for which there is no completely satisfactory therapy. Conventional ablative therapy requires repeated treatment, often for months or years. This study was undertaken to evaluate the safety and efficacy of 0.5% podofilox in patient-a... | ['Adult', 'Condylomata Acuminata', 'Double-Blind Method', 'Humans', 'Male', 'Neoplasm Recurrence, Local', 'Penile Neoplasms', 'Podophyllotoxin', 'Randomized Controlled Trials as Topic', 'Self Administration'] | 2,186,623 | [['M01.060.116'], ['C01.221.812.640.220', 'C01.778.640.220', 'C01.925.256.650.810.217', 'C01.925.813.220', 'C01.925.825.810.110', 'C01.925.928.914.217', 'C17.800.838.790.810.110'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photocatalytic inactivation of Cryptosporidium parvum with TiO(2) and low-pressure ultraviolet irradiation. | This study investigated the efficacy of low-pressure ultraviolet (UV) irradiation and the synergistic effect of UV/titanium dioxide (TiO(2)) photocatalysis on Cryptosporidium parvum oocyst inactivation. At UV doses of 2.7, 8.0, and 40mJ/cm(2), oocyst inactivation was 1.3, 2.6, and 3.3log(10), respectively. Reactive oxy... | ['Animals', 'Catalysis', 'Cell Line, Tumor', 'Cryptosporidium parvum', 'Humans', 'Photochemistry', 'Titanium', 'Ultraviolet Rays'] | 18,037,465 | [['B01.050'], ['G02.130'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.043.075.189.250.150.160.170'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.181.529.711'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Potentiometric sensor fabrication having 2D sarcosine memories and analytical features. | In this study, a simple, rapid and sensitive method based on novel molecular imprinted polymeric sensor has been developed and validated for the determination of prostate cancer metabolite biomarker. The molecularly imprinted polymer (MIP) has been synthesized by emulsion polymerization, using sarcosine as template mol... | ['Biomarkers, Tumor', 'Histidine', 'Humans', 'Hydrogen-Ion Concentration', 'Limit of Detection', 'Molecular Imprinting', 'Polymers', 'Potentiometry', 'Reproducibility of Results', 'Sarcosine', 'Spectroscopy, Fourier Transform Infrared'] | 27,612,708 | [['D23.101.140'], ['D12.125.072.329', 'D12.125.142.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.196.655', 'E05.197.453', 'J01.897.836.249.437'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E05.196.922.750', 'E0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Atrazine removal from water by polycation-clay composites: effect of dissolved organic matter and comparison to activated carbon. | Atrazine removal from water by two polycations pre-adsorbed on montmorillonite was studied. Batch experiments demonstrated that the most suitable composite poly (4-vinylpyridine-co-styrene)-montmorillonite (PVP-co-S90%-mont.) removed 90-99% of atrazine (0.5-28 ppm) within 20-40 min at 0.367% w/w. Calculations employing... | ['Aluminum Silicates', 'Atrazine', 'Charcoal', 'Clay', 'Filtration', 'Kinetics', 'Models, Chemical', 'Organic Chemicals', 'Polyamines', 'Polyelectrolytes', 'Solubility', 'Suspensions', 'Water'] | 19,038,414 | [['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['D03.383.931.247'], ['D01.268.150.150'], ['D20.721.250', 'G01.311.820.250', 'G16.500.275.815.250', 'N06.230.600.250'], ['E05.196.454', 'G01.280', 'G02.263'], ['G01.374.661', 'G02.111.490'], ['E05.599.495'], ['D02'], ['D02.092.78... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Study on pinocytosis and antigen presentation by murine peritoneal macrophages to T cells in vitro after cisplatin treatment. | Macrophage monolayers showed significantly increased rate of pinocytosis on incubation with cisplatin (10 micrograms/ml). Further, the rate of pinocytosis was compared with macrophages treated with LPS (10 micrograms/ml). Cisplatin treated macrophages also showed enhanced capacity of antigen presentation to T cells in ... | ['Animals', 'Antigens', 'Cells, Cultured', 'Cisplatin', 'Macrophage Activation', 'Macrophages', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Peritoneum', 'Pinocytosis'] | 3,250,354 | [['B01.050'], ['D23.050'], ['A11.251'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['G12.287.500'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of time-dependent risks for infection, rejection, and death after pulmonary transplantation. | Infection and rejection remain the greatest threats to the survival of pulmonary allograft recipients. Furthermore, a relationship may exist between these events, because the occurrence of one may predispose to the other. By using multivariate analysis for repeated events, we analyzed the risk factors for bacterial, fu... | ['Adolescent', 'Adult', 'Aged', 'Anti-Bacterial Agents', 'Bronchiolitis Obliterans', 'Child', 'Child, Preschool', 'Cytomegalovirus Infections', 'Female', 'Graft Rejection', 'Humans', 'Immunosuppression', 'Infant', 'Lung Diseases', 'Lung Transplantation', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Premedication', ... | 7,815,807 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['C08.127.446.135.140', 'C08.381.495.146.135.140'], ['M01.060.406'], ['M01.060.406.448'], ['C01.925.256.466.245'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.450', 'E05.478.610'], ['M01.060.703'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Radiopaque contrast media. XLIV - Preclinical studies with a new nonionic contrast agent. | L-5-alpha-hydroxypropionylamino-2,4,6-triiodoisophthalic acid di-(1,3-dihydroxy-2-propylamide), abbreviated Iopamidol, a new non-ionic water soluble contrast agent for angiography, myelography, ventriculography and for contrast reinforced computer-assisted axial tomography is described. Extensive preclinical testing sh... | ['Animals', 'Blood Pressure', 'Chemical Phenomena', 'Chemistry', 'Dogs', 'Iothalamic Acid', 'Mice', 'Rabbits', 'Rats', 'Solubility', 'Viscosity'] | 923,795 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G02'], ['H01.181'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.241.223.100.400.880.430', 'D02.455.426.559.389.127.375.880.430'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.968.700'], ['B01.050.150.900.649.313.992.635.505.700... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Carotid-cavernous fistula treatment with ethylene vinyl alcohol (onyx) exclusively through anterior venous approach. | The type of venous drainage of a direct carotid-cavernous fistula is an important issue to consider for the endovascular therapeutic decision. In case of an inadequate posterior drainage associated with a good anterior drainage, the facial vein is a useful alternative. The exclusive embolization with ethylene vinyl alc... | ['Adolescent', 'Balloon Occlusion', 'Carotid Artery, Internal', 'Carotid-Cavernous Sinus Fistula', 'Cerebral Angiography', 'Collateral Circulation', 'Craniocerebral Trauma', 'Dimethyl Sulfoxide', 'Embolization, Therapeutic', 'Female', 'Humans', 'Polyvinyls', 'Radiography, Interventional', 'Tomography, X-Ray Computed', ... | 22,544,869 | [['M01.060.057'], ['E02.148.106', 'E02.520.392.500', 'E02.926.500.074', 'E05.157.063'], ['A07.015.114.186.200.230'], ['C10.228.140.300.200.480', 'C10.228.140.300.350.500.350', 'C10.900.250.300.400', 'C14.240.850.750.147.500', 'C14.240.850.984.750.500', 'C14.907.150.125.500', 'C14.907.253.123.357', 'C14.907.253.535.500.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Contributions of 3'-overhang to the dissociation of small interfering RNAs from the PAZ domain: molecular dynamics simulation study. | RNA interference (RNAi) is a 'knock-down' reaction to reduce expression of a specific gene through highly regulated, enzyme-mediated processes. Small interfering RNAs (siRNAs) are RNA molecules that play an effector role in RNAi and can bind the PAZ domains present in Dicer and RISC. We investigated the interaction bet... | ['Binding Sites', 'Computer Simulation', 'Humans', 'Models, Molecular', 'Nucleic Acid Conformation', 'Protein Binding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'RNA Interference', 'RNA, Small Interfering', 'RNA-Induced Silencing Complex', 'Thermodynamics'] | 16,959,510 | [['G02.111.570.120'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['G02.111.570.820.486', 'G05.360.580'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.600'], ['G02.111.570.820.709.610'], ['G05.308.203.374.790'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Blood lactate accumulation and muscle deoxygenation during incremental exercise. | Near-infrared spectroscopy (NIRS) could allow insights into controversial issues related to blood lactate concentration ([La](b)) increases at submaximal workloads (). We combined, on five well-trained subjects [mountain climbers; peak O(2) consumption (VO(2peak)), 51.0 +/- 4.2 (SD) ml. kg(-1). min(-1)] performing incr... | ['Acidosis, Lactic', 'Adult', 'Exercise', 'Exercise Test', 'Hemoglobins', 'Humans', 'Lactic Acid', 'Male', 'Muscle, Skeletal', 'Oxygen', 'Oxygen Consumption', 'Oxyhemoglobins', 'Spectroscopy, Near-Infrared'] | 10,409,594 | [['C18.452.076.176.180'], ['M01.060.116'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459.450'], ['A02.633.567', 'A10.690.552.500'], ['D01.268.185.550', 'D01... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
One-step labeling of degenerative neurons in unfixed brain tissue samples using Fluoro-Jade C. | Neurodegeneration is the underlying cause of a vast majority of neurological disorders and often a result of brain trauma, stroke, or neurotoxic insult. Here we describe a simple method for labeling degenerating neurons in unfixed brain tissue samples. This method could provide a new avenue for identifying and harvesti... | ['Animals', 'Brain', 'Fluoresceins', 'Fluorescent Dyes', 'Neurodegenerative Diseases', 'Organic Chemicals', 'Rats', 'Rats, Sprague-Dawley', 'Staining and Labeling', 'Tissue Fixation'] | 22,546,475 | [['B01.050'], ['A08.186.211'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['C10.574'], ['D02'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.20... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peripheral insulin sensitivity is decreased by elevated non-esterified fatty acid level in dexamethasone-treated rats. | The pathogenesis of glucocorticoid-induced insulin resistance in the peripheral tissue was studied by perfusion experiments of the isolated rat hindquarter and insulin tolerance tests in the rat with the cutting off operation of blood supplies to the liver, kidneys, intestines and pancreas. The rat was injected with 0.... | ['Animals', 'Dexamethasone', 'Fatty Acids, Nonesterified', 'Glucagon', 'Glucocorticoids', 'Insulin', 'Insulin Resistance', 'Male', 'Palmitic Acid', 'Rats', 'Rats, Wistar'] | 10,782,750 | [['B01.050'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D10.251.310'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['D10.251.694.750... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treasure from garden: Bioactive compounds of buckwheat. | Buckwheat is a gluten-free crop under the family Polygonaceae abundant with beneficial phytochemicals that provide significant health benefits. It is cultivated and adapted in diverse ecological zones all over the world. Recently its popularity is expanding as a nutrient-rich healthy food with low-calories. The bioacti... | ['Apigenin', 'Fagopyrum', 'Flavonoids', 'Glucosides', 'Humans', 'Nutritive Value', 'Phytochemicals', 'Plant Extracts', 'Quercetin', 'Rutin', 'Seeds'] | 32,739,818 | [['D03.383.663.283.266.450.260.110', 'D03.633.100.150.266.450.260.110'], ['B01.650.940.800.575.912.250.825.333'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D09.408.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.660', 'J01.576.423.850.730.750', 'N06.850.601.750'], ['D23.704'], ['D2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Outcomes after abdominal aortic aneurysm repair requiring a suprarenal cross-clamp. | OBJECTIVE: The objective of this study was to analyze the early and late outcomes of patients who require a suprarenal aortic cross-clamp during elective open repair of an abdominal aortic aneurysm (AAA).METHODS: Patients from 1998 to 2012 who required a suprarenal aortic cross-clamp during elective open AAA repair wer... | ['Aged', 'Aortic Aneurysm, Abdominal', 'California', 'Disease-Free Survival', 'Elective Surgical Procedures', 'Equipment Design', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Male', 'Postoperative Complications', 'Radiography', 'Retrospective Studies', 'Survival Rate', 'Time Factors', 'Treatment Outcome', 'Va... | 24,856,910 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E04.249'], ['E05.320'], ['E05.318.37... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cohabitation of insulators and silencing elements in yeast subtelomeric regions. | In budding yeast, the telomeric DNA is flanked by a combination of two subtelomeric repetitive sequences, the X and Y' elements. We have investigated the influence of these sequences on telomeric silencing. The telomere-proximal portion of either X or Y' dampened silencing when located between the telomere and the repo... | ['Binding Sites', 'Centromere', 'Chromosomes, Fungal', 'DNA-Binding Proteins', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Models, Genetic', 'Protein Binding', 'Repetitive Sequences, Nucleic Acid', 'Reproduction', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Silent Information Regulat... | 10,228,166 | [['G02.111.570.120'], ['A11.284.430.106.279.345.190.160.165', 'G05.360.160.165'], ['A11.284.187.360', 'A19.311', 'G05.360.162.360'], ['D12.776.260'], ['D12.776.354'], ['G05.308.330'], ['E05.599.395.397'], ['G02.111.679', 'G03.808'], ['G02.111.570.080.708', 'G05.360.080.708'], ['G08.686.784'], ['B01.300.107.795.785.800'... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HIV infection and AIDS 2: transmission and diagnosis. | This is a two-part unit on HIV infection and Aids. Part 1 reviewed the evolving global and national epidemiology of HIV infection and Aids. This second part examines routes of transmission, diagnosis and antiretroviral treatment. | ['HIV Infections', 'Humans'] | 18,979,956 | [['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Morphology and phagocytic activity of hemocytes of Oncomelania hupensis]. | Hemocytes from Oncomelania hupensis hemolymph were studied in vitro. Spreading amoebocytes were the most common cell type. The average sizes of amoebocytes from Anhui and Yunnan were 8.42 +/- 0.73 x 7.46 +/- 0.52 microns and 7.63 +/- 0.65 x 6.85 +/- 0.54 microns, respectively. The nucleus was round in shape, and eosino... | ['Animals', 'Disease Reservoirs', 'Hemocytes', 'Hemolymph', 'Host-Parasite Interactions', 'Phagocytosis', 'Snails'] | 7,955,155 | [['B01.050'], ['N06.850.520.203.250'], ['A11.118.480', 'A15.145.229.480'], ['A13.453'], ['G16.527.200.400'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.688'], ['B01.050.500.644.400.750']] | ['Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. | BACKGROUND: Obstructive sleep apnea (OSA) is associated with obesity, insulin resistance (IR) and diabetes. Continuous positive airway pressure (CPAP) rapidly mitigates OSA in obese subjects but its metabolic effects are not well-characterized. We postulated that CPAP will decrease IR, ghrelin and resistin and increase... | ['Adiponectin', 'Appetite Regulation', 'Biomarkers', 'Blood Glucose', 'Body Weight', 'Chi-Square Distribution', 'Continuous Positive Airway Pressure', 'Female', 'Ghrelin', 'Humans', 'Insulin', 'Insulin Resistance', 'Linear Models', 'Male', 'Middle Aged', 'Obesity', 'Resistin', 'Sleep', 'Sleep Apnea, Obstructive', 'Texa... | 21,676,224 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['G07.203.650.170', 'G07.203.650.390.070.290', 'G10.261.390.070.290'], ['D23.101'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Dose optimization for different medical imaging tasks from exposure index, exposure control factor, and MAS in digital radiography. | In radiographic examination, not all medical imaging tasks require the same level of image quality or diagnostic information. Criteria should be established for different imaging tasks to avoid excessive doses where there is no clear net benefit in the diagnosis or the image quality. An exposure index provided by manuf... | ['Environmental Exposure', 'Female', 'Humans', 'Male', 'Middle Aged', 'Phantoms, Imaging', 'Quality Control', 'Radiation Dosage', 'Radiographic Image Enhancement'] | 22,850,227 | [['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E07.671'], ['J01.897.608'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600']] | ['Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Ecological risk assessment of perfluooroctane sulfonate to aquatic fauna from a bayou adjacent to former fire training areas at a US Air Force installation. | Per- and polyfluoroalkyl substances (PFASs) continue to receive significant attention, with particular concern for PFASs such as perfluorooctane sulfonate (PFOS), which was a constituent of aqueous film-forming foam used widely as a fire suppressant for aircraft since the 1970s. We were interested in the potential for ... | ['Alkanesulfonic Acids', 'Animals', 'Aquatic Organisms', 'Ecology', 'Ecosystem', 'Environmental Exposure', 'Fires', 'Fishes', 'Fluorocarbons', 'Geography', 'Models, Theoretical', 'Risk Assessment', 'Species Specificity', 'Toxicity Tests', 'United States', 'Water Pollutants, Chemical'] | 29,691,889 | [['D02.455.326.146.100', 'D02.886.645.600.055'], ['B01.050'], ['B05.080', 'G16.500.275.725.500.650.075'], ['H01.158.273.248', 'H01.277.249'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350'], ['N06.230.216'], ['B01.050.150.900.493'], ['D02.455.526.510.435'], ['H01.277.500'], ['E05.599'], ['E05.318.740.600.800.71... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Life satisfaction in early adolescence: personal, neighborhood, school, family, and peer influences. | Drawing from an ecological assets framework as well as research and theory on positive youth development, this study examined the relationship of early adolescents' satisfaction with life to trait optimism and assets representing the social contexts in which early adolescents spend most of their time. Self-reports of s... | ['Adolescent', 'Attitude', 'Canada', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Multilevel Analysis', 'Parent-Child Relations', 'Peer Group', 'Personal Satisfaction', 'Psychology, Adolescent', 'Residence Characteristics', 'Schools', 'Self Report', 'Social Support'] | 21,042,841 | [['M01.060.057'], ['F01.100'], ['Z01.107.567.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.520.830.562'], ['F01.829.263.370.290'], ['F01.829.316.483'], ['F01.145.677'], ['F04.096.628.065'], ['N01.224.791', 'N06.850.505.40... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Cultivation of feed yeasts on media with carbohydrates]. | The different culture of yeasts oxidizing hydrocarbons and the accompanying microflora are, under certain physico-chemical conditions, in metabiotic relationships which provide stability of the system. These relationships were studied with yeast cultures belonging to the Candida genus and oxidizing hydrocarbons. The re... | ['Bacteria', 'Candida', 'Carbohydrate Metabolism', 'Culture Media', 'Fungi', 'Hydrogen-Ion Concentration', 'Paraffin', 'Temperature'] | 26,855 | [['B03'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['G02.111.158', 'G03.191'], ['D27.720.470.305', 'E07.206'], ['B01.300'], ['G02.300'], ['D02.455.612'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice. | Many previous studies have indicated the adverse effects of bisphenol A (BPA) on sperm production and quality; however, the mechanisms underlying BPA male reproductive toxicity have yet to be elucidated. The main purpose of this study was to investigate the effect of perinatal exposure to BPA on the spermatogenic capac... | ['Animals', 'Benzhydryl Compounds', 'Endocrine Disruptors', 'Female', 'Male', 'Mice, Inbred C57BL', 'NF-kappa B', 'Phenols', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Receptors, Aryl Hydrocarbon', 'Sperm Count', 'Spermatogenesis', 'Spermatozoa', 'Testis', 'Testosterone', 'Toll-Like Receptor 4', 'Tumor Necrosis... | 30,275,377 | [['B01.050'], ['D02.455.426.559.389.115'], ['D27.505.696.353', 'D27.888.141'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776.930.600'], ['D02.455.426.559.389.657'], ['G08.686.784.769'], ['C13.703.824.500'], ['D12.776.26... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The ontogenic development of 2',3'-cyclic nucleotide 3'-phosphohydrolase in the corpus callosum in relation to oligodendroglial proliferation, myelination and the distribution of fat-containing glial cells. | The development of CNP'ase activity in the corpus callosum of infants dying from different causes has been compared with myelin formation and oligodendroglial proliferation determined by quantitative histological methods. Cases were classified according to the distribution of neutral lipid in capillary endothelia (Clas... | ["2',3'-Cyclic Nucleotide 3'-Phosphodiesterase", "2',3'-Cyclic-Nucleotide Phosphodiesterases", 'Animals', 'Cell Count', 'Cell Differentiation', 'Corpus Callosum', 'Humans', 'Hypoxia, Brain', 'Infant', 'Lipid Metabolism', 'Myelin Sheath', 'Neuroglia', 'Oligodendroglia', 'Phosphoric Diester Hydrolases', 'Rats', 'Spinal C... | 6,321,131 | [['D08.811.277.352.640.160.500', 'D12.776.631.580.124'], ['D08.811.277.352.640.160'], ['B01.050'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.152'], ['A08.186.211.200.885.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.624', 'C23.888.852.079.797'], ['M01.060.70... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Customizing the coefficients of urban domestic pollutant discharge and their driving mechanisms: Evidence from the Taihu Basin, China. | Discharge of urban domestic pollution has risen sharply during China's extensive urbanization. Together with understanding the complexity of influencing factors underpinning this rise, it has become a pressing issue to estimate total discharge and illustrate its driving mechanism scientifically. This paper reports on t... | ['China', 'Cities', 'Environmental Monitoring', 'Female', 'Humans', 'Residence Characteristics', 'Urbanization', 'Waste Management'] | 29,502,010 | [['Z01.252.474.164'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.224.791', 'N06.850.505.400.800'], ['I01.880.853.400.726'], ['N06.850.780.200.800.800.900', 'N06.850.860.510.900']] | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Reorganization of human motor cortex after hand replantation. | In 10 patients, reorganizational changes of the motor cortex contralateral to a replanted hand (MCreplant) were studied one to 14 years after complete traumatic amputation and consecutive successful replantation of the hand. The organizational state of MCreplant was assessed for the deafferentated and peripherally deef... | ['Adolescent', 'Adult', 'Aged', 'Brain Mapping', 'Child, Preschool', 'Female', 'Hand', 'Hand Injuries', 'Humans', 'Magnetics', 'Male', 'Middle Aged', 'Motor Cortex', 'Replantation'] | 11,506,408 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['M01.060.406.448'], ['A01.378.800.667'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.671.493'], ['M01.060.116.630'], ['A08.186.211.200.885.287.500.270.548', 'A08.18... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Assessing the role of IKCa channels in generating the sAHP of CA1 hippocampal pyramidal cells. | Our previous work reported that KCa3.1 (IKCa) channels are expressed in CA1 hippocampal pyramidal cells and contribute to the slow afterhyperpolarization that regulates spike accommodation in these cells. The current report presents data from single cell RT-PCR that further reveals mRNA in CA1 cells that corresponds to... | ['Animals', 'CA1 Region, Hippocampal', 'Intermediate-Conductance Calcium-Activated Potassium Channels', 'Male', 'Membrane Potentials', 'Patch-Clamp Techniques', 'Polymerase Chain Reaction', 'Potassium Channel Blockers', 'Pyramidal Cells', 'Pyrazoles', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley'] | 26,950,800 | [['B01.050'], ['A08.186.211.180.405.099', 'A08.186.211.200.885.287.500.345.099'], ['D12.776.157.530.400.600.150.249', 'D12.776.543.550.450.750.150.249', 'D12.776.543.585.400.750.150.249'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.200.500.905', 'E05.242.800'], ['E05.393.620.500'], ['D27.505.519.56... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of prolactin on growth and the estrogen receptor level of human breast cancer cells (MCF-7). | The intracellular specific 17beta-estradiol binding in the human breast cancer cell line, MCF-7, was shown to be modified by prolactin. Both ovine and human prolactin doubled the estradiol receptor (E2R) level, but the latter was at least 10 times more stimulatory on a concentration basis. Most of the E2R complex (appr... | ["3',5'-Cyclic-AMP Phosphodiesterases", 'Breast Neoplasms', 'Bucladesine', 'Cell Division', 'Cell Nucleus', 'Cells, Cultured', 'Cyclic AMP', 'Cytosol', 'DNA, Neoplasm', 'Drug Interactions', 'Estradiol', 'Humans', 'Insulin', 'Neoplasm Proteins', 'Prolactin', 'Protein Binding', 'Receptors, Estrogen', 'Theophylline'] | 189,915 | [['D08.811.277.352.640.150', 'D12.644.360.008', 'D12.776.476.008'], ['C04.588.180', 'C17.800.090.500'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recurrent laryngeal nerve injury: an experience with 310 thyroidectomies. | BACKGROUND: Thyroid surgery has been associated with complications ranging from nerve injury to death. Improvements in techniques have reduced the mortality rate to minimum. Morbidity, however, remains a significant concern. This study was designed to determine the prevalence of recurrent laryngeal nerve (RLN) injury a... | ['Adult', 'Age Distribution', 'Female', 'Humans', 'Intraoperative Complications', 'Male', 'Middle Aged', 'Prospective Studies', 'Recurrent Laryngeal Nerve Injuries', 'Sex Distribution', 'Thyroidectomy'] | 18,444,591 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C08.360.424.500', 'C09.400.424.500', 'C10.292.200.937.750.500', 'C1... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses. | Complex mechanisms are required to form neuromuscular synapses, direct their subsequent maturation, and maintain the synapse throughout life. Transcriptional and post-translational pathways play important roles in synaptic differentiation and direct the accumulation of the neurotransmitter receptors, acetylcholine rece... | ['Actins', 'Adult', 'Animals', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Microfilament Proteins', 'Microtubule-Associated Proteins', 'Microtubules', 'Muscle Proteins', 'Mutation, Missense', 'Myasthenic Syndromes, Congenital', 'Neuromuscular Junction', 'Pedigree', '... | 30,842,214 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116'], ['B01.050'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.5... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Atmospheric methane oxidizers are present and active in Canadian high Arctic soils. | The melting of permafrost and the associated potential for methane emissions to the atmosphere are major concerns in the context of global warming. However, soils can also represent a significant sink for methane through the activity of methane-oxidizing bacteria (MOB). In this study, we looked at the activity, diversi... | ['Air', 'Arctic Regions', 'Bacterial Proteins', 'Canada', 'Genes, Bacterial', 'Genetic Variation', 'Methane', 'Methylococcaceae', 'Molecular Sequence Data', 'Oxidation-Reduction', 'Oxygenases', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Soil Microbiology'] | 24,450,397 | [['G16.500.275.063.150', 'N06.230.300.100.150'], ['Z01.208'], ['D12.776.097'], ['Z01.107.567.176'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.365'], ['D02.455.326.146.571'], ['B03.440.400.425.500', 'B03.660.250.500'], ['L01.453.245.667'], ['G02.700', 'G03.295.531'], ['... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Sex Differences in Early Postnatal Microglial Colonization of the Developing Rat Hippocampus Following a Single-Day Alcohol Exposure. | Microglia are involved in various homeostatic processes in the brain, including phagocytosis, apoptosis, and synaptic pruning. Sex differences in microglia colonization of the developing brain have been reported, but have not been established following alcohol insult. Developmental alcohol exposure represents a neuroim... | ['Animals', 'Animals, Newborn', 'Central Nervous System Depressants', 'Ethanol', 'Female', 'Fetal Alcohol Spectrum Disorders', 'Hippocampus', 'Male', 'Microglia', 'Neurogenesis', 'Neuroimmunomodulation', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Long-Evans', 'Sex Characteristics'] | 29,274,031 | [['B01.050'], ['B01.050.050.282'], ['D27.505.696.277', 'D27.505.954.427.210'], ['D02.033.375'], ['C13.703.277.220', 'C16.300.070', 'C25.775.100.087.323'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A08.637.400', 'A11.650.400'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors. | A small set of isoprenoid bisphosphonates ethers has been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid biosynthesis. Five of these compounds inhibit geranylgeranyl diphosphate synthase (GGDPS) with IC50 values below 1 ìM in enzyme assays, but in cells their apparent ... | ['Diphosphonates', 'Ethers', 'Farnesyltranstransferase', 'Humans', 'K562 Cells', 'Polyisoprenyl Phosphates', 'Protein Binding', 'Protein Prenylation', 'Structure-Activity Relationship', 'Terpenes', 'rab GTP-Binding Proteins', 'rap1 GTP-Binding Proteins', 'ras Proteins'] | 25,952,057 | [['D02.705.429.500'], ['D02.355'], ['D08.811.913.225.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.510', 'A11.251.860.180.510', 'A11.443.240.497.480'], ['D02.455.849.690', 'D02.705.400.725'], ['G02.111.679', 'G03.808'], ['G02.111.660.871.790.600.400', 'G02.111.672.500', 'G02.111.691.600.400'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical analysis of tamoxifen, an anti-neoplastic agent, in plasma. | Tamoxifen, a phenylstilbene derivative, is currently being used to treat metastatic breast cancer. We describe an analytical method for monitoring the parent drug and its 4-hydroxylated derivative in whole blood and plasma. After extraction from biological media, the analytes are converted to highly fluorescent product... | ['Breast Neoplasms', 'Female', 'Humans', 'Magnetic Resonance Spectroscopy', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet', 'Tamoxifen', 'Ultraviolet Rays'] | 688,611 | [['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D02.455.426.559.389.150.700.900'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.7... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Murine monoclonal antibodies reactive with a variety of androgen independent Dunning rat prostate adenocarcinoma sublines also reactive with human prostate adenocarcinoma. | Murine hybridoma-derived monoclonal antibody (MCA) to Dunning rat prostate adenocarcinoma R-3327HIS (androgen independent type) has been produced by fusing P3x63 Ag8-653 myeloma cells with splenocytes of BALB/c mice which were immunized with R-3327HIS tumor cell membranes. One monoclonal antibody designated MCA-R1 (IgG... | ['Adenocarcinoma', 'Adult', 'Androgens', 'Animals', 'Antibodies, Monoclonal', 'Antibody Specificity', 'Blotting, Western', 'Cell Line', 'Cross Reactions', 'Electrophoresis, Polyacrylamide Gel', 'Fluorescent Antibody Technique', 'Humans', 'Hybridomas', 'Immunoenzyme Techniques', 'Male', 'Mice', 'Mice, Inbred BALB C', 'P... | 2,056,591 | [['C04.557.470.200.025'], ['M01.060.116'], ['D27.505.696.399.472.161'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['G12.122... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Formation of nicotine addiction in mongrel white rats]. | A study was made of the possibility of forming nicotine addiction in laboratory rats and using it as the basis for the design of experimental nicotine toxicomania. Experiments were carried out on 56 rats placed in individual cages with a possibility of free choice between water and 0.005% nicotine solution for 2 to 4 m... | ['Animals', 'Cocaine', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Drinking', 'Humans', 'Male', 'Nicotine', 'Rats', 'Substance-Related Disorders', 'Time Factors'] | 6,542,434 | [['B01.050'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.203.650.283.249', 'G10.261.330.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence that ibuprofen antagonizes selective actions of estrogen and tamoxifen on rat bone. | Studies were performed to determine if the nonsteroidal anti-inflammatory drug ibuprofen alters bone and mineral metabolism in female rats. In experiment 1, four groups of growing rats underwent either sham operation or ovariectomy (OVX). One week later, controlled-release pellets with ibuprofen or placebo were implant... | ['Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Bone Development', 'Bone Diseases, Metabolic', 'Bone Remodeling', 'Bone and Bones', 'Estradiol', 'Estrogen Antagonists', 'Female', 'Ibuprofen', 'Ovariectomy', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Estrogen', 'Tamoxifen', 'Uterus'] | 9,610,751 | [['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['C05.116.198', 'C18.452.104'], ['G11.427.213', 'G16.762.150'], ['A02.835.232', 'A10.165.265'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.347.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of 5-hydroxy-2, 3-dihydrophthalazine-1, 4-dione and luminol as co-substrates for detection of horseradish peroxidase in enhanced chemiluminescent reactions. | The utility of 5-hydroxy-2, 3-dihydrophthalazine-1, 4-dione (HDP) as a co-substrate for the chemiluminescent detection of horseradish peroxidase was assessed. Several substituted aryl boronic acid derivatives (4-phenyl, 4-iodo) acted as potent enhancers of the peroxidase catalyzed reaction. Addition of chelating agents... | ['Boronic Acids', 'Edetic Acid', 'Horseradish Peroxidase', 'Hydrogen Peroxide', 'Iodobenzenes', 'Luminescent Measurements', 'Luminol', 'Photometry', 'Polysorbates', 'Substrate Specificity'] | 8,926,307 | [['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['D08.811.682.732.512'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D02.455.426.559.389.454', 'D02.455.526.581.496'], ['E05.196.712.516'], ['D03.383.710.350'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Metabolic bone disease in adults receiving long-term parenteral nutrition: longitudinal study with regional densitometry and bone biopsy. | A syndrome of bone pain and fractures has been described in patients receiving long-term support from parenteral nutrition containing large quantities of aluminium or vitamin D2. Whether this same syndrome occurs in patients supported by current therapeutic regimens is controversial. In this study, bone health was long... | ['Adult', 'Aged', 'Aluminum', 'Biopsy', 'Blood Chemical Analysis', 'Bone Density', 'Bone Diseases, Metabolic', 'Bone and Bones', 'Ergocalciferols', 'Female', 'Follow-Up Studies', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Parenteral Nutrition', 'Time Factors'] | 8,505,825 | [['M01.060.116'], ['M01.060.116.100'], ['D01.268.557.050', 'D01.552.547.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.225.124.100', 'E05.200.124.100'], ['G11.427.100'], ['C05.116.198', 'C18.452.104'], ['A02... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spindle assembly checkpoint signaling and sister chromatid cohesion are disrupted by HPV E6-mediated transformation. | Aneuploidy, a condition that results from unequal partitioning of chromosomes during mitosis, is a hallmark of many cancers, including those caused by human papillomaviruses (HPVs). E6 and E7 are the primary transforming proteins in HPV that drive tumor progression. In this study, we stably expressed E6 and E7 in nonca... | ['Aneuploidy', 'Cell Cycle Proteins', 'Cell Transformation, Viral', 'Chromatids', 'Chromosome Segregation', 'Human papillomavirus 16', 'Humans', 'Kinetochores', 'M Phase Cell Cycle Checkpoints', 'Mitosis', 'Oncogene Proteins, Viral', 'Papillomavirus E7 Proteins', 'Repressor Proteins', 'Signal Transduction', 'Spindle Ap... | 28,539,402 | [['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['D12.776.167'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['A11.284.430.106.279.345.190.160.175', 'G05.360.160.175'], ['G04.144.220.220.625', 'G05.113.220.625'], ['B04.280.210.655.050.616', 'B04.613.204.655.050.616'], ['B01.050.150.90... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[HIV infection in the Stavropol' region]. | The data on the dynamics of HIV infection in the Stavropol Territory beginning with 1987 are given. The situation became aggravated after 1996, and its sharp deterioration occurred in 2000 when 138 cases of HIV infection were detected and the area of this infection increased. In most cases patients became infected beyo... | ['Adult', 'Child', 'Female', 'HIV Infections', 'Humans', 'Male', 'Narcotics', 'Risk Factors', 'Russia', 'Sexual Behavior', 'Substance Abuse, Intravenous'] | 12,718,170 | [['M01.060.116'], ['M01.060.406'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.600', 'D27.505.696.663.850.014.760', 'D27.505.954.427.040.550', 'D27.505.954.427.210.600'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Analysis of Stage-Specific Gene Expression Profiles in the Uterine Endometrium during Pregnancy in Pigs. | The uterine endometrium plays a critical role in regulating the estrous cycle and the establishment and maintenance of pregnancy in mammalian species. Many studies have investigated the expression and function of genes in the uterine endometrium, but the global expression pattern of genes and relationships among genes ... | ['Animals', 'Cluster Analysis', 'Endometrium', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Gene Regulatory Networks', 'Molecular Sequence Annotation', 'Pregnancy', 'Real-Time Polymerase Chain Reaction', 'Reproducibility of Results', 'Sus scrofa', 'Uterus'] | 26,580,069 | [['B01.050'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['A05.360.319.679.490'], ['E05.393.332'], ['G05.308.310'], ['G05.360.080.689.360'], ['E05.393.760.479', 'L01.453.245.667.580'], ['G08.686.784.769'], ['E05.393.620.500.706'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.85... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Forced vital capacity and maximal respiratory pressures in patients with mild and moderate scoliosis. | Lung function and maximal respiratory pressures of 24 adolescent females with mild-to-moderate idiopathic scoliosis (spinal curvature 10-60 degrees) were determined and compared with 38 age- and sex-matched controls. Twelve patients with moderate scoliosis (Cobb angle 35-60 degrees) had significantly reduced mean value... | ['Adolescent', 'Female', 'Humans', 'Manometry', 'Pressure', 'Respiratory Muscles', 'Scoliosis', 'Spirometry', 'Vital Capacity', 'Work of Breathing'] | 3,344,168 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.559'], ['G01.374.715'], ['A02.633.567.900'], ['C05.116.900.800.875'], ['E01.370.386.700.750'], ['E01.370.386.700.485.750.900', 'G09.772.850.970'], ['E01.370.386.700.975', 'G09.772.965']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transient ischemic attack: a complication of mitral valve prolapse in pregnancy. | A case of transient ischemic attack presumably due to cardiogenic thromboembolism during pregnancy is described in a 32-year-old woman. The patient had documented mitral valve prolapse which was uncomplicated until this episode. This is the first report in the literature of such a complication during pregnancy. The cli... | ['Adult', 'Female', 'Humans', 'Ischemic Attack, Transient', 'Mitral Valve Prolapse', 'Pregnancy', 'Pregnancy Complications, Cardiovascular'] | 3,374,915 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['C14.280.484.400.500'], ['G08.686.784.769'], ['C13.703.634', 'C14.583']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Loss of heterozygosity assay for molecular detection of cancer using energy-transfer primers and capillary array electrophoresis. | Microsatellite DNA loci are useful markers for the detection of loss of heterozygosity (LOH) and microsatellite instability (MI) associated with primary cancers. To carry out large-scale studies of LOH and MI in cancer progression, high-throughput instrumentation and assays with high accuracy and sensitivity need to be... | ['DNA Primers', 'DNA, Neoplasm', 'Disease Progression', 'Electrophoresis, Capillary', 'Energy Transfer', 'Fluorescent Dyes', 'Humans', 'Kidney Neoplasms', 'Loss of Heterozygosity', 'Mutation', 'Radioisotopes', 'Reproducibility of Results'] | 10,958,639 | [['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.425'], ['C23.550.291.656'], ['E05.196.401.190', 'E05.301.300.190'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Allelotype of gastric adenocarcinoma. | Gastric adenocarcinoma is a leading cause of cancer mortality world-wide. Yet, the underlying molecular events important in the development of this cancer are largely undefined. Thus, we performed a comprehensive survey for allelic loss on our panel of xenografted human gastric carcinomas. Contaminating normal stromal ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Alleles', 'Animals', 'Female', 'Humans', 'Loss of Heterozygosity', 'Male', 'Mice', 'Middle Aged', 'Neoplasm Transplantation', 'Stomach Neoplasms', 'Transplantation, Heterologous'] | 10,197,609 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590.029.530'], ['B01.050.150.900.649.313.992.635.505.500'], ['M01.060.116.630'], ['E05.624'], ['C04.588.274.476.767', 'C06.301.371... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Space radiation dosimetry by combination of integrating dosemeters. | Generally, individual monitoring is performed with a small personal dosemeter which responds to radiation by giving a necessary operational quantity such as personal dose equivalent. In space, however, such a personal dosemeter has not yet been available and a dose equivalent is estimated through elaborate work using e... | ['Cosmic Radiation', 'Dose-Response Relationship, Radiation', 'Occupational Exposure', 'Radiation Dosage', 'Radiation Protection', 'Reproducibility of Results', 'Semiconductors', 'Sensitivity and Specificity', 'Space Flight', 'Systems Integration', 'Thermoluminescent Dosimetry'] | 16,709,705 | [['G01.060.185', 'G01.750.750.235', 'G16.500.200', 'N06.230.300.100.300'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['N06.850.460.350.600'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['N06.850.810.425'], ['E05.318.370.725', 'E05.337.851', 'N05.715.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Ultrastructural sequence of myelin degradation. I. Wallerian degeneration in the rat optic nerve. | The ultrastructural events in myelin degradation in the rat optic nerve following transection have been studied. Myelin debris was found in cells similar to multipotential glia cells (Vaughn and Peters, 1968) as well as in astrocytes and in few oligodendrocytes. The different types of inclusions found during myelin deg... | ['Animals', 'Astrocytes', 'Inclusion Bodies', 'Myelin Proteins', 'Nerve Degeneration', 'Neuroglia', 'Oligodendroglia', 'Optic Nerve', 'Rats', 'Wallerian Degeneration'] | 213,928 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['A11.284.420'], ['D12.776.543.620', 'D12.776.631.580'], ['C23.550.737'], ['A08.637', 'A11.650'], ['A08.637.600', 'A11.650.600'], ['A08.800.800.120.680'], ['B01.050.150.900.649.313.992.635.505.700'], ['C23.550.737.750']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. | Shorter androgen receptor gene CAG repeat length has been associated with an increased risk of prostate cancer, an earlier age of onset, and more advanced stage of disease. Studies comparing the distribution of CAG repeat lengths within different populations have reported that racial groups with higher prostate cancer ... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'DNA, Neoplasm', 'Genetic Predisposition to Disease', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Probability', 'Prognosis', 'Prostatic Neoplasms', 'Receptors, ... | 15,479,493 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D13.444.308.425'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.30... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Noninvasive diagnosis of liver fibrosis and cirrhosis in chronic hepatitis C patients. | BACKGROUND: We aimed to derive a simple noninvasive test for liver-fibrosis staging and then estimate its performance against four simple noninvasive tests in chronic hepatitis C (CHC) patients.METHODS: CHC patients were divided into two cohorts: an estimation set (n = 324) and a validation set (n = 524). Liver fibrosi... | ['Adult', 'Analysis of Variance', 'Area Under Curve', 'Biomarkers', 'Cohort Studies', 'Female', 'Hepatitis C, Chronic', 'Humans', 'Linear Models', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'ROC Curve', 'Reproducibility of Results'] | 23,460,258 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D23.101'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cervical nodal metastasis from intrathoracic esophageal squamous cell carcinoma is not necessarily an incurable disease. | BACKGROUND: It remains controversial if metastatic cervical lymph nodes in patients with intrathoracic esophageal cancer signify distant metastases and are therefore incurable or if they should be regarded as regional spread with a potential for cure.MATERIAL AND METHODS: Patients with intrathoracic esophageal squamous... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Carcinoma, Squamous Cell', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Esophageal Neoplasms', 'Esophagectomy', 'Female', 'Humans', 'Lymph Node Excision', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neck', 'Neoadjuvant Therap... | 18,704,592 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['E04.210.346'], ['B01.050.150.900.649.31... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of substrate utilization by indirect calorimetry during cyclic and continuous total parenteral nutrition. | Five male adult home patients were studied in a randomized order under continuous (24 h/d) and nocturnal cyclic (15 h/d) isocaloric, isonitrogenous total parenteral nutrition (TPN). They received 2626 +/- 265 total kcal/d as 60% dextrose and 40% lipids; the 3-h lipid infusion was followed by the dextrose amino acid inf... | ['Adult', 'Amino Acids', 'Calorimetry, Indirect', 'Circadian Rhythm', 'Energy Metabolism', 'Glucose', 'Humans', 'Lipid Metabolism', 'Lipids', 'Male', 'Oxidation-Reduction', 'Oxygen Consumption', 'Parenteral Nutrition, Total', 'Random Allocation', 'Ventilation-Perfusion Ratio'] | 2,105,052 | [['M01.060.116'], ['D12.125'], ['E05.196.131.655'], ['G07.180.562.190'], ['G03.295'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458'], ['D10'], ['G02.700', 'G03.295.531'], ['G03.680'], ['E02.421.505.575', 'E02.642.500.505.750'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular and Serological Evidence of Leishmania Infection in Stray Dogs from Visceral Leishmaniasis-Endemic Areas of Bangladesh. | Visceral leishmaniasis (VL), or kala-azar, is mainly caused by two closely related Leishmania species, Leishmania infantum and Leishmania donovani Leishmania infantum is responsible for zoonotic VL, with dogs as the main reservoir host in the Mediterranean, the Middle East, Asia, and South America. In the Indian subcon... | ['Animals', 'Bangladesh', 'Chromatography, Affinity', 'DNA, Kinetoplast', 'Disease Reservoirs', 'Dog Diseases', 'Dogs', 'Endemic Diseases', 'Female', 'Geography', 'Humans', 'Leishmania donovani', 'Leishmania infantum', 'Leishmaniasis', 'Leishmaniasis, Visceral', 'Male', 'Polymerase Chain Reaction', 'Psychodidae'] | 27,382,083 | [['B01.050'], ['Z01.252.245.131'], ['E05.196.181.400.170'], ['D13.444.308.283.225.200', 'D13.444.308.442.200'], ['N06.850.520.203.250'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['N06.850.392'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.268.475.868.488.230'], ['B01.268.475... | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
SHB1 and CCA1 interaction desensitizes light responses and enhances thermomorphogenesis. | Light and temperature are two important environmental signals to plants. After dawn, photo-activated phytochromes translocate into the nucleus and interact with a family of negative basic helix-loop-helix PIF regulators. Subsequent phosphorylation and degradation of PIFs triggers a series of photomorphogenic responses.... | ['Acclimatization', 'Arabidopsis', 'Arabidopsis Proteins', 'Basic Helix-Loop-Helix Transcription Factors', 'DNA-Binding Proteins', 'Gene Expression Regulation, Plant', 'Light Signal Transduction', 'Photosynthesis', 'Phytochrome', 'Sunlight', 'Temperature', 'Transcription Factors'] | 31,308,379 | [['G07.025.133', 'G16.012.500.133'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D12.776.260.103', 'D12.776.930.125'], ['D12.776.260'], ['G05.308.375'], ['G02.111.820.480', 'G04.835.480'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Experiences in the testing of standard data on roentgen diagnostic equipment]. | The TUV (German Standards Control Body) are performing inspections of standard characteristics of different devices for medical diagnostic radiology used in medical consulting as well as in hospitals. The inspections are carried out according to the recommendations of the German rule "Richtlinien ?ber die Aufzeichnunge... | ['Germany, West', 'Humans', 'Quality Control', 'Radiography', 'Radiography, Dental', 'Technology, Radiologic'] | 4,001,772 | [['Z01.586.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.608'], ['E01.370.350.700'], ['E01.370.350.700.720', 'E06.342.764'], ['E05.920', 'H02.010.850', 'J01.897.891']] | ['Geographicals [Z]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. | The aim of this study was to evaluate the prevalence of serum immunoglobulin (Ig)G and IgA antibodies to recombinant chlamydial 60 kDa heat shock protein (C-hsp60) and to assess the prevalence of serum IgG antibodies to recombinant chlamydial 70 kDa heat shock protein (C-hsp70) in Chlamydia-associated chronic salpingit... | ['Adult', 'Antibodies, Anti-Idiotypic', 'Antibody Formation', 'Bacterial Outer Membrane Proteins', 'Blotting, Western', 'Chaperonin 60', 'Chlamydia', 'Chlamydia Infections', 'Constriction, Pathologic', 'Fallopian Tube Diseases', 'Female', 'HSP70 Heat-Shock Proteins', 'Humans', 'Immunoglobulin A', 'Immunoglobulin G', 'I... | 8,815,069 | [['M01.060.116'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['G12.450.050.370.250'], ['D12.776.097.120', 'D12.776.543.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.277.040.025.142.500.500', 'D12.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of phosphonium salts and phosphoranes on the acetylcholinesterase activity and on the viability of Schistosoma mansoni parasites. | In this study we investigated the effects of a series of phosphonium salts and phosphoranes on the catalytic activity of acetylcholinesterase and on the viability of the various life stages of Schistosoma mansoni worms. All the tested compounds showed an inhibitory effect towards the S. mansoni acetylcholinesterase (AC... | ['Acetylcholinesterase', 'Animals', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred ICR', 'Phosphoranes', 'Schistosoma mansoni', 'Schistosomiasis', 'Schistosomicides', 'Snails', 'Trityl Compounds'] | 6,511,145 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['D01.695.550', 'D02.705.675'], ['B01.050.500.500.736.715.77... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Scanning electron microscopic evaluation of the skin surface after ultrasound exposure. | BACKGROUND: Transdermal drug-delivery systems have become widely accepted clinically for the administration of several systemic drugs. Recently, research on ultrasound irradiation to facilitate the penetration of drugs through the skin have been reported. The present study investigated the morphological changes induced... | ['Animals', 'Humans', 'Mice', 'Mice, Hairless', 'Microscopy, Electron, Scanning', 'Skin', 'Ultrasonics', 'Ultrasonography'] | 9,096,784 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.200', 'B01.050.150.900.649.313.992.635.505.500.400.200', 'B01.050.150.900.649.313.992.635.505.500.550.230'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A17.815'], ['H01.671.031.84... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Lamin disassembly kinetics: a cell-free system with extracts from mitotic HeLa cells. | We describe a cell-free system in which a postribosomal supernatant from metaphase HeLa cells induces prophase-like changes in permeabilized HeLa cell populations as evidenced by the nuclear lamin disassembly and chromatin condensation. We have attempted to characterize the cell-free system with permeabilized HeLa cell... | ['Adenosine Triphosphate', 'Animals', 'Antibodies, Monoclonal', 'Cell Division', 'Cell Extracts', 'Cell Nucleus', 'Cell-Free System', 'Chromosomes', 'Fluorescent Antibody Technique', 'HeLa Cells', 'Humans', 'Interphase', 'Kinetics', 'Lamins', 'Microscopy, Fluorescence', 'Nuclear Proteins', 'Permeability', 'Tissue Extra... | 3,288,486 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D20.777.162'], ['A11.284.430.106', 'A11.284.430.214.190.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia. | Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of pre... | ['Amphetamine', 'Animals', 'Behavior, Animal', 'Dopamine', 'Dopamine Agents', 'Homeostasis', 'Microdialysis', 'Motor Activity', 'Nucleus Accumbens', 'Prefrontal Cortex', 'Rats', 'Schizophrenia', 'Social Behavior', 'Social Isolation'] | 20,884,342 | [['D02.092.471.683.152.110'], ['B01.050'], ['F01.145.113'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.625.150', 'D27.505.696.577.150'], ['G07.410'], ['E05.196.353.500'], ['F01.145.632', 'G11.427.410.698'], ['A08.186.211.200.885.287.249.487.775.500'], ['A08.186.211.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
An epidemiological profile of brucellosis in Tabuk Province, Saudi Arabia. | All 137 brucellosis cases occurring in Tabuk Province, Saudi Arabia in 1997 were studied retrospectively. Brucella agglutination titre of > or = 1/80, or rising titre plus history of typical signs and symptoms were considered evidence of infection. The incidence rate was 34/100,000, mean age 33.8 +/- 13.9 years (range:... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', "Agricultural Workers' Diseases", 'Animals', 'Animals, Domestic', 'Brucella abortus', 'Brucella melitensis', 'Brucella suis', 'Brucellosis', 'Child', 'Child, Preschool', 'Female', 'Hepatomegaly', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Milk', 'Prevalence', 'Res... | 15,332,781 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['C24.080'], ['B01.050'], ['B01.050.050.116'], ['B03.440.400.425.215.500.100', 'B03.660.050.070.100.100'], ['B03.440.400.425.215.500.500', 'B03.660.050.070.100.500'], ['B03.440.400.425.215.500.750', 'B03.660.0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Retrospective serological and genetic study of the distribution of hantaviruses in Greece. | A retrospective serological and genetic study of hantaviruses responsible for hemorrhagic fever with renal syndrome (HFRS) in Greece during the last 17 years is presented. Fifty-one serum samples taken from 30 HFRS cases previously diagnosed by immunofluorescence assay were tested by ELISA for IgG (Hantaan, Dobrava, an... | ['Adult', 'Aged', 'Antibodies, Viral', 'DNA Primers', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Genome, Viral', 'Greece', 'Hantavirus', 'Hemorrhagic Fever with Renal Syndrome', 'Humans', 'Male', 'Middle Aged', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Viral', 'Retrospective Studies', 'Sequence Analysis, RNA... | 9,661,842 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.360... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
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