Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines. | Genetic and epigenetic alterations mark colorectal cancer (CRC). Global hypomethylation is observed in nearly all CRC, but a distinct subset of CRC show the CpG Island Methylator Phenotype (CIMP). These tumors show DNA hypermethylation of a specific subset of CpG islands, resulting in transcriptional downregulation of ... | ['Acetyltransferases', 'Adenocarcinoma', 'Aged', 'Biomarkers, Tumor', 'Cohort Studies', 'Colorectal Neoplasms', 'DNA Methylation', 'Fatty Acid Elongases', 'Female', 'Follow-Up Studies', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Prognosis', 'Survival R... | 28,931,069 | [['D08.811.913.050.134'], ['C04.557.470.200.025'], ['M01.060.116.100'], ['D23.101.140'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.11... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Clusterin is a potential serum marker of hepatic carcinoma]. | OBJECTIVE: To determine the differentially expressed serum proteins in patients with hepatoma carcinoma and identify a putative diagnostic marker.METHOD: The isobaric tags for relative and absolute quantitation (iTRAQ) labeling method and LC-MALDI-TOF/TOF MS detection method were used to quantify serum proteins in hepa... | ['Biomarkers', 'Carcinoma, Hepatocellular', 'Case-Control Studies', 'Clusterin', 'Humans', 'Liver Neoplasms', 'Mass Spectrometry', 'RNA, Messenger', 'Tumor Cells, Cultured'] | 22,964,148 | [['D23.101'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.395.207', 'D12.776.580.215'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A simple model of cannibalism. | A simple nonlinear discrete model is derived for the dynamics of a two-age class population consisting of juveniles and adults that includes cannibalism of juveniles by adults. The model is investigated analytically and numerically. It is shown how even this very simple model, by incorporating the negative and positive... | ['Age Factors', 'Animals', 'Cannibalism', 'Mathematics', 'Models, Biological', 'Population Dynamics'] | 1,806,108 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F01.145.113.547.200'], ['H01.548'], ['E05.599.395'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Brain vessels near muscle autografts are sites for entry of isogeneic macrophages into brain. | An autograft of skeletal muscle on rat dorsal medulla is a permanent opening in the blood-brain barrier to solutes. Is the graft also a site for the entry of exogenous, isogeneic leukocytes? Five weeks after inserting the graft, peritoneal macrophages (M phi) from inbred Fischer rats were activated by phorbol myristate... | ['Animals', 'Antibodies, Monoclonal', 'Capillaries', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Cell Movement', 'Cerebellum', 'Cerebral Ventricles', 'Immunohistochemistry', 'Intercellular Adhesion Molecule-1', 'Interferon-gamma', 'Lymphocyte Function-Associated Antigen-1', 'Lymphotoxin-alpha', 'Macrophage Activation'... | 7,507,059 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A07.015.461.165'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['G04.198', 'G07.568.500.180'], ['A08.186.211.132.810.428.200'], ['A08.186.211.140'], ['E01.370.225.500.607.51... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploring variations in ovarian cancer survival by age and stage (ICBP SurvMark-2): A population-based study. | OBJECTIVE: The study aims to evaluate the differences in ovarian cancer survival by age and stage at diagnosis within and across seven high-income countries.METHODS: We analyzed data from 58,161 women diagnosed with ovarian cancer during 2010-2014, followed until 31 December 2015, from 21 population-based cancer regist... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Australia', 'Canada', 'Carcinoma, Ovarian Epithelial', 'Female', 'Humans', 'Ireland', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'New Zealand', 'Norway', 'Ovarian Neoplasms', 'Registries', 'United Kingdom', 'Young Adult'] | 32,005,583 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.639.100', 'Z01.678.100.373'], ['Z01.107.567.176'], ['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.3... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Long-term outcome following successful catheter ablation of atrial tachycardia originating from the pulmonary veins: absence of late atrial fibrillation. | OBJECTIVES: This study aimed to characterize the long-term outcome and incidence of atrial fibrillation (AF) in patients following catheter ablation of focal atrial tachycardia (AT) from the pulmonary veins (PV).BACKGROUND: Although both AT and AF may originate from ectopic foci within PVs, it is unknown whether PV AT ... | ['Adult', 'Atrial Fibrillation', 'Catheter Ablation', 'Electrocardiography', 'Electrophysiologic Techniques, Cardiac', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pulmonary Veins', 'Risk Assessment', 'Risk Factors', 'Tachycardia, Supraventricular', 'Time Factors', 'Treatment Outcome', 'Victoria', 'Young Adult'] | 20,132,395 | [['M01.060.116'], ['C14.280.067.198', 'C23.550.073.198'], ['E02.808.750.500', 'E04.014.760.500'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.370.380.245', 'E01.370.405.267'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.908.713'], ['E05.318.740.600.800.715', 'N04.452.871.71... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Enhanced efficacy of pH-sensitive nystatin liposomes against Cryptococcus neoformans in murine model. | OBJECTIVES: To evaluate the efficacy of pH-sensitive liposomes of nystatin against Cryptococcus neoformans infection in a murine model.METHODS: In the present study, we investigated the antifungal activity of nystatin entrapped in pH-sensitive liposomes in a murine model. Mice infected with C. neoformans were treated w... | ['Animals', 'Antifungal Agents', 'Brain', 'Cryptococcosis', 'Drug Carriers', 'Hydrogen-Ion Concentration', 'Intercalating Agents', 'Liposomes', 'Liver', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Nystatin', 'Phosphatidylcholines', 'Survival Analysis'] | 16,368,700 | [['B01.050'], ['D27.505.954.122.136'], ['A08.186.211'], ['C01.150.703.248'], ['D26.255.260', 'E02.319.300.380'], ['G02.300'], ['D27.720.470.410.360'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Efficacy and tolerability of fesoterodine in women with overactive bladder. | INTRODUCTION AND HYPOTHESIS: We assessed fesoterodine efficacy and tolerability in women with overactive bladder (OAB).METHODS: This post hoc analysis of pooled data from two clinical trials included 1,548 women with OAB randomized to placebo, fesoterodine 4 or 8 mg, or tolterodine extended release (ER) 4 mg (in 1 tria... | ['Adult', 'Aged', 'Aged, 80 and over', 'Benzhydryl Compounds', 'Constipation', 'Cresols', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Female', 'Humans', 'Middle Aged', 'Muscarinic Antagonists', 'Phenylpropanolamine', 'Tolterodine Tartrate', 'Treatment Outcome', 'Urinary Bladder, Overactive'] | 19,495,545 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.455.426.559.389.115'], ['C23.888.821.150'], ['D02.455.426.559.389.657.239'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The picture superiority effect: support for the distinctiveness model. | The form change paradigm was used to explore the basis for the picture superiority effect. Recognition memory for studied pictures and words was tested in their study form or the alternate form. Form change cost was defined as the difference between recognition performance for same and different form items. Based on th... | ['Adult', 'Attention', 'Discrimination Learning', 'Female', 'Humans', 'Male', 'Mental Recall', 'Pattern Recognition, Visual', 'Reaction Time', 'Semantics'] | 10,696,280 | [['M01.060.116'], ['F02.830.104.214'], ['F02.463.425.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.641'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['L01.559.598.745']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Demonstration that orf2 encodes the feline immunodeficiency virus transactivating (Tat) protein and characterization of a unique gene product with partial rev activity. | The long PCR technique was used to amplify the three size classes of viral mRNAs produced in cells infected by feline immunodeficiency virus (FIV). We identified in the env region a new splice acceptor site that generated two transcripts, each coding for an 11-kDa protein, p11(rev), whose function is unknown. The small... | ['Animals', 'Gene Products, rev', 'Gene Products, tat', 'Immunodeficiency Virus, Feline', 'Open Reading Frames', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Rabbits', 'Terminal Repeat Sequences', 'Trans-Activators', 'Transcriptional Activation'] | 9,847,366 | [['B01.050'], ['D12.776.157.725.076', 'D12.776.664.962.186', 'D12.776.964.925.984.385'], ['D12.776.260.755.199', 'D12.776.930.900.199', 'D12.776.964.900.750.750', 'D12.776.964.925.984.400'], ['B04.820.650.589.530.400'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['E05.393.620.500'], ['D13.444.735.544'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[How to improve the histopathological diagnosis of hepatocellular benign affections (adenoma versus focal nodular hyperplasia) in daily practice?]. | Adenomas of the liver and focal nodular hyperplasia (FNH) are benign hepatocellular affection and their distinguishing in a needle biopsy sample and sometimes also in a surgical specimen causes often a problem. Although it might seem that the differentiation of the benign conditions is of a low value for the clinicians... | ['Adenoma', 'Focal Nodular Hyperplasia', 'Humans', 'Immunohistochemistry', 'Liver Neoplasms'] | 24,289,486 | [['C04.557.470.035'], ['C06.552.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transfer of group B streptococci from mothers to neonates: effect of whole body washing of mothers with chlorhexidine. | Seven babies born to 28 mothers who were vaginal carriers of group B streptococci and who bathed or showered with chlorhexidine during the last 2 weeks of pregnancy were colonized with an organism of the same phage type as their mothers. In contrast, nine babies of 14 carrier mothers who were given no instructions rega... | ['Baths', 'Chlorhexidine', 'Female', 'Humans', 'Infant, Newborn', 'Pregnancy', 'Streptococcus agalactiae', 'Vagina'] | 2,865,290 | [['E02.056.110'], ['D02.078.370.141.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769'], ['B03.353.750.737.872.100', 'B03.510.400.800.872.100', 'B03.510.550.737.872.100'], ['A05.360.319.779']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cyanide, carboxyhemoglobin and blood acid-base state in animals exposed to combustion products of various combinations of acrylic fiber and gauze. | In order to examine the usefulness of blood cyanide concentrations as an indicator of whether or not a victim was alive at the start of a fire, blood cyanide concentrations were measured in the bodies that we autopsied in our institute between January 1986 and March, 1987. In the present study, bodies with advanced dec... | ['Aged', 'Animals', 'Blood Gas Analysis', 'Carboxyhemoglobin', 'Cyanides', 'Female', 'Fires', 'Forensic Medicine', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Middle Aged', 'Rabbits', 'Rats', 'Rats, Inbred Strains'] | 2,759,522 | [['M01.060.116.100'], ['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D12.776.124.400.141', 'D12.776.422.316.762.149'], ['D01.248.497.158.291', 'D01.625.400.100'], ['N06.230.216'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'],... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Metabolic effects of vitamin D active metabolites in monolayer and micromass cultures of nucleus pulposus and annulus fibrosus cells isolated from human intervertebral disc. | Intragenic polymorphisms in the vitamin D receptor gene are linked to disc degeneration features, suggesting that alterations in the vitamer-mediated signalling could be involved in the pathophysiology of the disc and that interaction of disc cells with vitamin D metabolites may be critical for disc health. The vitamer... | ['Adult', 'Base Sequence', 'Cell Proliferation', 'DNA Primers', 'Female', 'Humans', 'Immunohistochemistry', 'Intervertebral Disc', 'Male', 'Middle Aged', 'Real-Time Polymerase Chain Reaction', 'Receptors, Calcitriol', 'Vitamin D'] | 22,481,027 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.161.750', 'G07.345.249.410.750'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients. | Opisthorchis viverrini (O. viverrini; known as human liver fluke) is a major health problem in the northeastern region of Thailand. Infection with O. viverrini is the cause of hepatobiliary disease and cholangiocarcinoma (CCA). Previous studies demonstrated specific antibodies to crude O. viverrini antigens in serum fr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Antibodies, Helminth', 'Antigens, Helminth', 'Bile Duct Neoplasms', 'Bile Ducts, Intrahepatic', 'Cholangiocarcinoma', 'False Negative Reactions', 'False Positive Reactions', 'Female', 'Humans', 'Immunoglobulin A, Secretory', 'Immunoglobulin G', 'Male', 'Middle Aged', '... | 20,446,100 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D23.050.223'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A03.159.183.158', 'A03.620.150'], ['C04.557.470... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Patient-tailored, imaging-guided, long-term temozolomide chemotherapy in patients with glioblastoma. | We present two patients with glioblastoma with an unusually stable clinical course and long-term survival who were treated after surgery and radiotherapy with adjuvant temozolomide (TMZ) chemotherapy for 17 and 20 cycles, respectively. Afterward, adjuvant TMZ chemotherapy was discontinued in one patient and the dosage ... | ['Adult', 'Antineoplastic Agents, Alkylating', 'Brain Neoplasms', 'Carbon Radioisotopes', 'Dacarbazine', 'Dideoxynucleosides', 'Fluorine Radioisotopes', 'Glioblastoma', 'Humans', 'Methionine', 'Middle Aged', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Temozolomide'] | 20,128,997 | [['M01.060.116'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D02.925.200', 'D03.383.129.308.240'], ['D13.570.230.500'], ['D01.496.749.340'], ['C04.557.465.625.600.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A study of admission criteria and early management of adult patients with acute asthma. | We studied the admission criteria and first 24-hour management of 62 asthmatic patients admitted from Accident and Emergency (A&E) department of a state hospital. Data was collected prospectively over a 6-month period from the doctors' medical records with reference to recommendations of the Malaysian Thoracic Society ... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Asthma', 'Emergency Service, Hospital', 'Female', 'Hospitals, Urban', 'Humans', 'Malaysia', 'Male', 'Medical Records', 'Middle Aged', 'Patient Admission', 'Prospective Studies'] | 15,190,635 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['N02.278.421.660'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Can experts predict health risk from family genograms? | BACKGROUND: The family genogram is sometimes used to aid diagnostic, therapeutic, and preventive care decisions. This study evaluated the efficacy of genograms for predicting health risk in comparison to predictions made using demographic and chart review data.METHODS: Six physicians with expertise in using genograms w... | ['Family Health', 'Female', 'Health Status Indicators', 'Humans', 'Male', 'Medical History Taking', 'Physicians, Family', 'Probability', 'Prognosis', 'Risk Factors'] | 1,577,214 | [['N01.400.300'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.510'], ['M01.526.485.810.770', 'N02.360.810.770'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['E01.789'], ['E05.318.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Antimutagenicity of selenium-enriched rice on mice exposure to cyclophosphamide and mitomycin C. | The in vivo antimutagenicity of Se-enriched rice was evaluated by bone marrow micronucleus and testicle chromosomal aberrations assay in mice exposed to cyclophosphamide (CP) and mitomycin C (MMC). Regular rice did not alter the occurrence of chemical-induced mutation. However, the addition of Se-enriched rice or selen... | ['Animals', 'Antimutagenic Agents', 'Bone Marrow Cells', 'Chromosome Aberrations', 'Cyclophosphamide', 'Diet', 'Female', 'Male', 'Mice', 'Micronucleus Tests', 'Mitomycin', 'Oryza', 'Selenium', 'Sodium Selenite'] | 15,737,685 | [['B01.050'], ['D27.505.696.706.080', 'D27.720.799.042'], ['A11.148', 'A15.378.316'], ['C23.550.210', 'G05.365.590.175'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['G07.203.650.240'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.560.598'], ['D02.806.400.249.350', 'D03.383.097.500.350', 'D03.633... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Meta-analysis comparing different behavioral treatments for late-life anxiety. | OBJECTIVE: To evaluate the efficacy of different types of behavioral treatments for geriatric anxiety (cognitive behavior therapy [CBT] alone, CBT with relaxation training [RT], and RT alone).METHOD: The authors compared effect sizes from 19 trials. Analyses were based on uncontrolled outcomes (comparing posttreatment ... | ['Aged', 'Anxiety', 'Anxiety Disorders', 'Clinical Trials as Topic', 'Cognitive Behavioral Therapy', 'Depression', 'Humans', 'Middle Aged', 'Relaxation Therapy', 'Treatment Outcome'] | 19,155,744 | [['M01.060.116.100'], ['F01.470.132'], ['F03.080'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['F04.754.137.350'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.190.525.875', 'F04.754.137.750'], ['E01.789.800', 'N04.761.559.590.800'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Scoliosis model created by pedicle screw tethering in immature goats: the feasibility, reliability, and complications. | STUDY DESIGN: An in vivo model of scoliosis was established in immature goats.OBJECTIVE: To assess the feasibility, reliability, and complications of the innovative animal model.SUMMARY OF BACKGROUND DATA: Among the methods of creating a scoliotic model, posterior asymmetric tethering of spine yielded encouraging resul... | ['Animals', 'Bone Screws', 'Disease Models, Animal', 'Feasibility Studies', 'Female', 'Goats', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Reproducibility of Results', 'Scoliosis', 'Spine', 'Tomography, X-Ray Computed'] | 19,934,810 | [['B01.050'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.500.380.513'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['E0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Elevation of c-abl-mRNA in human leukemic B lymphoblasts. | Analysis of v-abl-homologous transcripts in peripheral blood leukocytes from 20 leukemia patients revealed a 5-kb species as the major abl-mRNA present. Elevated levels of this 5-kb transcript, together with detectable levels of 2- and 10-kb abl-homologous species, were observed in mRNA samples from two patients, one w... | ['B-Lymphocytes', 'Base Sequence', 'Humans', 'Karyotyping', 'Leukemia', 'Philadelphia Chromosome', 'Proto-Oncogenes', 'RNA, Messenger', 'Transcription, Genetic'] | 3,491,935 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The X-ray crystal structure of an Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase reveals a (beta/alpha)(8) catalytic domain, two ancillary domains and active site residues key for transglycosylation activity. | Glycoside hydrolase family GH85 is a family of endo-beta-N-acetylglucosaminidases that is responsible for the hydrolysis of beta-1,4 linkage in the N,N-diacetylchitobiose core of N-linked glycans. The endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) is of particular interest, given its increas... | ['Acetylglucosaminidase', 'Arthrobacter', 'Asparagine', 'Carbohydrate Conformation', 'Catalytic Domain', 'Crystallography, X-Ray', 'Glycosylation', 'Models, Molecular', 'Protein Structure, Secondary'] | 19,327,363 | [['D08.811.277.450.483.180.500'], ['B03.510.024.850.050', 'B03.510.460.400.400.049.074'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['G02.111.570.820.235'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.196.309.742.225'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['E05.599.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of the human sperm acrosome reaction with mannose-containing neoglycoprotein ligands. | In the interest of classifying cases of male factor infertility, we have paid particular attention to the sugar ligand binding properties of the human sperm surface and the functional capacity of the acrosome for exocytosis--key parameters for assessing sperm fertilizing ability. Zona recognition and binding involve th... | ['Acrosome', 'Allosteric Regulation', 'Exocytosis', 'Female', 'Glycoproteins', 'Humans', 'Infertility, Male', 'Ligands', 'Male', 'Mannose', 'Protein Structure, Tertiary', 'Spermatozoa'] | 9,395,260 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['G02.111.044'], ['G04.468'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['D27.720.470.480'], ['D09.947.875.359.588'], ['G02.111.570.820.709.610'], ['A05.360.490.890', '... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Ethical aspects of preimplantation diagnostics]. | Pre-implantation Genetic Diagnosis (PGD) enables to genetic examination of an embryo springed up in vitro before his transfer to mother's womb. The ethical valuation of this affair is different. Fundamentally, ethic-medical debate takes the interest in practical advantages and in unwholesome of this method. But ethic-t... | ['Christianity', 'Ethics, Medical', 'Female', 'Human Rights', 'Humans', 'Pregnancy', 'Preimplantation Diagnosis', 'Religion and Medicine'] | 10,816,959 | [['K01.844.188'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['I01.880.604.473', 'N03.706.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E01.370.378.625'], ['K01.844.619']] | ['Humanities [K]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Cis/trans conformational equilibrium across the N-methylphenylalanine- N-methylphenylalanine peptide bond of arginine vasopressin analogs. | Two cyclic analogs of vasopressin, -Pro-Arg-Gly-NH(2) (1) and -Pro-Arg-Gly-NH(2) (2) were synthesized by the solid phase method. Their structure was determined in aqueous solution by two-dimensional NMR techniques and simulated annealing algorithm from an extended template in X-PLOR. The total chemical shift correlatio... | ['Arginine Vasopressin', 'Hydrogen Bonding', 'Isomerism', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Peptides, Cyclic', 'Phenylalanine'] | 15,102,051 | [['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['G02.282'], ['G02.111.570.685', 'G02.607.445'], ['E05.196.867.519'], ['G02.111.570.820'], ['D04.345.566', 'D12.644.641'], ['D12.125.072.050.685', 'D12.125.142.666']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system. | Adverse effects induced by HIV protease inhibitors (PIs) are a significant factor in limiting their clinical success. PIs directly contribute to peripheral insulin resistance and alterations in lipid metabolism. GS-8374 is a novel PI with potent antiretroviral activity and a favorable resistance profile. Here we report... | ['Adipocytes', 'Animals', 'Atazanavir Sulfate', 'Biological Transport', 'Cells, Cultured', 'Glucose', 'Glucose Clamp Technique', 'HIV Protease Inhibitors', 'Homeostasis', 'Humans', 'Insulin', 'Lopinavir', 'Male', 'Mice', 'Molecular Structure', 'Oligopeptides', 'Pyridines', 'Pyrimidinones', 'Rats', 'Rats, Wistar', 'Rito... | 21,245,443 | [['A11.329.114'], ['B01.050'], ['D03.383.725.068', 'D12.644.456.157'], ['G03.143'], ['A11.251'], ['D09.947.875.359.448'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['D27.505.519.389.745.900.500', 'D27.505.954.122.388.077.088.420'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential dose adjustments of immunosuppressants after resuming boosted versus unboosted HIV-protease inhibitors postliver transplant. | Pharmacokinetic (PK) interactions between protease inhibitors (PI(s)) and immunosuppressive agents (IS) are critical elements in the management of HIV-infected patients who undergo liver transplantation (LT(x)). The primary objective of this study was to evaluate the decreases in IS dosages necessary to maintain an app... | ['Adult', 'Chromatography, High Pressure Liquid', 'Cross-Sectional Studies', 'Dose-Response Relationship, Drug', 'Female', 'HIV Infections', 'HIV Protease Inhibitors', 'Humans', 'Immunosuppressive Agents', 'Liver Transplantation', 'Male', 'Middle Aged'] | 19,656,133 | [['M01.060.116'], ['E05.196.181.400.300'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.690.773.875', 'G07.690.936.500'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['D27.505.519.389.745.900.500', 'D... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diallyl sulfide induces growth inhibition and apoptosis of anaplastic thyroid cancer cells by mitochondrial signaling pathway. | Anaplastic thyroid carcinoma (ATC) is one of the most lethal solid tumors arising thyroid gland with dismal prognosis. One of the constituents of garlic, diallyl sulfide (DAS) was shown to inhibit chemically induced carcinogenesis in many animal models. This study examined whether DAS could induce growth inhibition and... | ['Allyl Compounds', 'Anticarcinogenic Agents', 'Apoptosis', 'Blotting, Western', 'Caspase 3', 'Caspase 9', 'Cell Line, Tumor', 'Cell Proliferation', 'Female', 'Flow Cytometry', 'Garlic', 'Humans', 'Male', 'Mitochondria', 'Signal Transduction', 'Sulfides', 'Thyroid Carcinoma, Anaplastic', 'Thyroid Neoplasms', 'Tumor Sup... | 20,219,414 | [['D02.455.326.271.122'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxic-oil syndrome. Gallium-67 scanning and bronchoalveolar lavage studies in patients with abnormal lung function. | The toxic-oil syndrome (TOS) is a multisystem disorder whose etiology and pathogenesis are as yet unknown. Lung alterations persist in a significant number of TOS patients due to the underlying vascular lesion. Computer-assisted 67Ga scanning and bronchoalveolar lavage (BAL) studies were performed in 14 TOS patients wi... | ['Adolescent', 'Adult', 'Bronchi', 'Fatty Acids, Monounsaturated', 'Female', 'Food Contamination', 'Gallium Radioisotopes', 'Humans', 'Lung Diseases', 'Male', 'Middle Aged', 'Oils', 'Plant Oils', 'Pulmonary Alveoli', 'Radionuclide Imaging', 'Rapeseed Oil', 'Respiratory Function Tests', 'Syndrome', 'Therapeutic Irrigati... | 4,028,850 | [['M01.060.057'], ['M01.060.116'], ['A04.411.125'], ['D10.251.355.325'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['D01.268.556.289.500.400', 'D01.496.360.400', 'D01.496.749.360', 'D01.552.544.289.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['M01.060.116.63... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The clinical relevance of luteal phase deficiency: a committee opinion. | Luteal phase deficiency (LPD) has been described in healthy normally menstruating women and in association with other medical conditions. While progesterone is important for the process of implantation and early embryonic development, LPD, as an independent entity causing infertility, has not been proven. | ['Age Factors', 'Aging', 'Biomarkers', 'Biopsy', 'Corpus Luteum Maintenance', 'Embryo Implantation', 'Female', 'Humans', 'Infertility, Female', 'Luteal Phase', 'Obesity', 'Ovary', 'Predictive Value of Tests', 'Pregnancy', 'Progesterone', 'Risk Assessment', 'Risk Factors'] | 22,819,186 | [['N05.715.350.075', 'N06.850.490.250'], ['G07.345.124'], ['D23.101'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G08.686.784.690.355.500', 'G08.686.784.769.520.500'], ['G08.686.784.170.104.500'], ['B01.050.150.900.649... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The matching method for veins images. | BACKGROUND: A common problem in medical practice is the localization of subcutaneous veins and arteries. Automatization of this procedure may help to develop bloodbot rigs and improve use of image guided surgery.METHOD: It is not necessary to have a full 3D model in order to determine their location by calculating the ... | ['Algorithms', 'Humans', 'Imaging, Three-Dimensional', 'Pattern Recognition, Automated', 'Veins'] | 28,709,744 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['L01.399.750'], ['A07.015.908']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Apical Microleakage in Root Canals Obturated With 2 Different Endodontic Sealer Systems in Canine Teeth of Dogs. | An apical dye leakage test was utilized to compare 2 endodontic sealer systems commonly used in veterinary endodontic treatment. Rotary instrumentation followed by injection of 2 different sealers (GuttaFlow 2 and AH Plus) and a single master cone obturation technique were compared. Following obturation and restoration... | ['Animals', 'Cuspid', 'Dental Leakage', 'Dental Pulp Cavity', 'Dogs', 'Male', 'Root Canal Filling Materials', 'Root Canal Obturation'] | 28,631,551 | [['B01.050'], ['A14.549.167.860.200'], ['C07.793.221'], ['A14.549.167.900.265'], ['B01.050.150.900.649.313.750.250.216.200'], ['D25.339.859', 'J01.637.051.339.859'], ['E06.397.778.778']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
HIV-1 pol gene variation is sufficient for reconstruction of transmissions in the era of antiretroviral therapy. | OBJECTIVES: We wished to assess the potential of using HIV-1 pol gene for the identification of transmissions events by phylogenetic means in the era of antiretroviral drug selective pressure.DESIGN: The relatedness of the viruses within a large database of pol sequences generated from HIV-1 infected individuals from t... | ['Anti-HIV Agents', 'Databases, Genetic', 'Drug Resistance, Viral', 'Genes, env', 'Genes, gag', 'Genes, pol', 'Genetic Variation', 'HIV Infections', 'HIV-1', 'Humans', 'Phylogeny', 'Polymerase Chain Reaction', 'Sequence Alignment'] | 15,075,506 | [['D27.505.954.122.388.077.088'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.172'], ['G05.360.340.024.340.364.875.258', 'G05.360.340.358.024.875.258', '... | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity. | BACKGROUND: Blocking programmed death-1 (PD-1) is considered to be a promising strategy to improve T cell function, and this is being explored in many ongoing clinical trials. In fact, our knowledge about PD-1 is primarily based on the results of short-term experiments or observations, but how long-lasting PD-1 blockad... | ['A549 Cells', 'Animals', 'Cell Differentiation', 'Female', 'Gene Knockdown Techniques', 'Humans', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred NOD', 'Programmed Cell Death 1 Receptor', 'Receptors, Chimeric Antigen', 'T-Lymphocytes'] | 31,391,096 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['B01.050'], ['G04.152'], ['E05.393.335.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of human papillomavirus antibodies in young female subjects in England. | Sera from 1483 female subjects in England aged 10-29 years were tested. The age-standardised seroprevalence was 10.7% (95% confidence intervals 9.0-12.3) for human papillomavirus (HPV) 6, 2.7% (1.8-3.6) for HPV 11, 11.9% (10.2-13.6) for HPV 16, 4.7% (3.5-5.8) for HPV 18, and 20.7% (18.6-22.7) for any of the four types. | ['Adolescent', 'Adult', 'Antibodies, Viral', 'Child', 'England', 'Female', 'Humans', 'Papillomaviridae', 'Papillomavirus Infections', 'Prevalence', 'Seroepidemiologic Studies'] | 17,726,462 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['M01.060.406'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.280.210.655', 'B04.613.204.655'], ['C01.925.256.650', 'C01.925.928.725'], ['E05.318.308.985.525.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Partial protection against tissue cysts formation in pigs vaccinated with crude rhoptry proteins of Toxoplasma gondii. | A vaccine containing crude Toxoplasma gondii rhoptry proteins incorporated in the immunostimulating complexes (ISCOM) adjuvant was tested in pigs for protecting against tissue cyst formation. For this, 38 mixed breed pigs were divided into four groups, G1 (vaccinated challenged, n=10) received two doses (100 microg/dos... | ['Animals', 'Antibodies, Protozoan', 'Biological Assay', 'Blotting, Western', 'Body Temperature', 'Brain', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'ISCOMs', 'Immunoglobulin G', 'Male', 'Membrane Proteins', 'Mice', 'Muscle, Smooth', 'Protozoan Proteins', 'Protozoan Vaccines', 'Swine', 'Swine Diseases', 'Toxoplasm... | 15,845,275 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['E05.091'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211'], ['E05.478.566.350.170', 'E05.478.566.380.360... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synchronous carcinomas of cervix and ovary: case reports. | Four cases of synchronous carcinoma of the cervix and ovary are reported. In all cases the ovarian and cervical tumours were adenocarcinoma. Surgical management was determined by the extent of the tumours and the need for intracavitary radiotherapy. The dilema in determining whether the tumours were separate primaries ... | ['Adenocarcinoma', 'Adult', 'Female', 'Humans', 'Middle Aged', 'Neoplasms, Multiple Primary', 'Ovarian Neoplasms', 'Uterine Cervical Neoplasms'] | 7,653,409 | [['C04.557.470.200.025'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.651'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['C04.588.945.418.948.850', 'C13.351.500.852.593.131', 'C13.351.500.852.762.850', 'C13.35... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of Dissolved Organic Carbon on the Acute Toxicity of Copper and Zinc to White Sturgeon (Acipenser transmontanus) and a Cladoceran (Ceriodaphnia dubia). | We conducted acute lethality tests with white sturgeon (Acipenser transmontanus) and Ceriodaphnia dubia exposed to copper and zinc at dissolved organic carbon concentrations ranging from 0.5 to 5.5 mg/L. Dissolved organic carbon had minimal effects on zinc toxicity but did have a protective effect on acute copper toxic... | ['Animals', 'Carbon', 'Cladocera', 'Copper', 'Fishes', 'Water Pollutants, Chemical', 'Zinc'] | 31,499,580 | [['B01.050'], ['D01.268.150'], ['B01.050.500.131.365.150'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.050.150.900.493'], ['D27.888.284.903.655'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of 2'-deoxy-3'-thiacytidine (3TC) in human urine by liquid chromatography: direct injection with column switching. | 3TC (GR109714X) is a cytidine dideoxynucleoside analogue which has been shown to have in vitro activity against a variety of strains of HIV-1 and is currently being investigated in clinical trials as a treatment for HIV infection. An HPLC method for the determination of 3TC in human urine has been developed and validat... | ['Chromatography, High Pressure Liquid', 'HIV Infections', 'Humans', 'Lamivudine', 'Reproducibility of Results', 'Zalcitabine'] | 8,003,552 | [['E05.196.181.400.300'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.742.680.245.500.950.500', 'D13.570.230.329.950.500', 'D13.570.230.500.925.500', 'D13.570.685.245.500.950.500'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Inhibition of cellular glutathione biosynthesis by rifampicin in Mycobacterium smegmatis. | This study was carried out to investigate the mechanism of Rifampicin (RIF) induced glutathione (GSH) depletion in M. smegmatis. RIF at various concentrations decreased the activities of gamma glutamyl cysteine synthetase (GGCS) and GSH synthetase. Maximum decrease in the activities of biosynthetic enzymes of GSH was o... | ['Glutamate-Cysteine Ligase', 'Glutathione', 'Glutathione Synthase', 'Mycobacterium', 'Rifampin', 'gamma-Glutamyltransferase'] | 1,352,683 | [['D08.811.464.259.850.400'], ['D12.644.456.448'], ['D08.811.464.259.850.500'], ['B03.510.024.962.500', 'B03.510.460.400.410.552.552'], ['D03.633.400.811.700', 'D04.345.295.750.700'], ['D08.811.913.050.200.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three-year prevalence of healthcare-associated infections in Dutch nursing homes. | From November 2007 for a period of three years (2007-2009), we conducted an annual one-day prevalence study of healthcare-associated infections (HAIs) among nursing home residents in the Nijmegen region of The Netherlands. In the absence of national HAI definitions applicable to the nursing home setting, we used modifi... | ['Aged, 80 and over', 'Bacteremia', 'Bacterial Infections', 'Bronchopneumonia', 'Conjunctivitis', 'Cross Infection', 'Female', 'Gastroenteritis', 'Humans', 'Male', 'Netherlands', 'Nursing Homes', 'Prevalence'] | 21,435,737 | [['M01.060.116.100.080'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['C01.150.252'], ['C01.748.610.127', 'C08.127.509', 'C08.381.677.127', 'C08.730.610.127'], ['C11.187.183'], ['C01.248', 'C23.550.291.875.500'], ['C06.405.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['N0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts. | Transient activation of group I metabotropic glutamate receptors (mGluRs) with the selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) produces persistent prolongation of epileptiform bursts in guinea pig hippocampal slices, the maintenance of which can be reversibly suppressed with group I mGluR antagonists. To de... | ['Animals', 'Benzoates', 'Convulsants', 'Dose-Response Relationship, Drug', 'Epilepsy', 'Excitatory Amino Acid Agonists', 'Excitatory Amino Acid Antagonists', 'GABA Antagonists', 'Glycine', 'Guinea Pigs', 'Hippocampus', 'In Vitro Techniques', 'Membrane Potentials', 'Picrotoxin', 'Pyridines', 'Receptor, Metabotropic Glu... | 11,784,776 | [['B01.050'], ['D02.241.223.100', 'D02.455.426.559.389.127'], ['D27.505.696.282.224', 'D27.505.954.427.220.224'], ['G07.690.773.875', 'G07.690.936.500'], ['C10.228.140.490'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D27.505.519.625.240.300', 'D27.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Edge-to-edge tricuspid valve repair in hypoplastic left heart syndrome. | Tricuspid regurgitation (TR) is known to be a risk factor for mortality in the surgical management of patients with hypoplastic left heart syndrome (HLHS). Concomitant repair for TR should be considered when the TR is moderate to severe to achieve successful Fontan completion. The present case was a 20-month-old girl w... | ['Cardiac Surgical Procedures', 'Female', 'Fontan Procedure', 'Humans', 'Hypoplastic Left Heart Syndrome', 'Infant', 'Severity of Illness Index', 'Treatment Outcome', 'Tricuspid Valve', 'Tricuspid Valve Insufficiency', 'Ultrasonography'] | 18,066,643 | [['E04.100.376', 'E04.928.220'], ['E04.035.410.295', 'E04.100.376.410.295', 'E04.100.376.724.500', 'E04.100.814.868.875.295', 'E04.928.220.370.295', 'E04.928.220.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.240.400.625', 'C14.280.400.625', 'C16.131.240.400.625'], ['M01.060.703'], ['E05.318.308.980.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Abdominal compartment syndrome in the open abdomen. | BACKGROUND: Multiple methods exist to manage in the intensive care unit the patient with an open abdomen. An increasingly common method is the vacuum packed technique. This method accommodates considerable expansion of intra-abdominal contents and should obviate the potential development of the abdominal compartment sy... | ['Abdomen', 'Abdominal Injuries', 'Adult', 'Compartment Syndromes', 'Drainage', 'Female', 'Humans', 'Male', 'Occlusive Dressings', 'Pressure', 'Retrospective Studies'] | 12,413,323 | [['A01.923.047'], ['C26.017'], ['M01.060.116'], ['C05.651.180', 'C14.907.303'], ['E02.309', 'E04.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.101.650'], ['G01.374.715'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450... | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Karyotype abnormalities in a variant Chinese hamster cell line resistant to methyl methanesulphonate. | A variant cell population, isolated from V79-C13 Chinese hamster cells after two consecutive treatments with methyl methanesulphonate (MMS), was found to be highly resistant to killing by this alkylating agent. The resistant cell line was cytogenetically characterized both by the presence of a stable translocation invo... | ['Alkylating Agents', 'Animals', 'Cell Line', 'Chromosome Aberrations', 'Chromosome Banding', 'Chromosome Disorders', 'Chromosome Mapping', 'Cricetinae', 'Cricetulus', 'Drug Resistance', 'Karyotyping', 'Methyl Methanesulfonate'] | 8,690,612 | [['D27.505.519.124', 'D27.888.569.035'], ['B01.050'], ['A11.251.210'], ['C23.550.210', 'G05.365.590.175'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['C16.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of alpha 1 and alpha 2 heavy-chain constant-region genes in common variable hypogammaglobulinaemia patients with undetectable IgA. | Five patients with common variable hypogammaglobulinaemia with undetectable levels of IgA in serum and saliva were investigated for immunoglobulin structural gene defects. All five patients carried in their genome alpha 1 and alpha 2 genes as detected in Southern blotting analysis by means of a cloned C alpha gene prob... | ['Agammaglobulinemia', 'DNA', 'Genes', 'Humans', 'Immunoglobulin A', 'Immunoglobulin Constant Regions', 'Immunoglobulin Heavy Chains', 'Immunoglobulin alpha-Chains', 'Immunoglobulins'] | 6,438,795 | [['C15.378.147.142', 'C15.604.515.032', 'C20.673.088'], ['D13.444.308'], ['G05.360.340.024.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.776.377.715.548.114.619.026'], ['D12.776.124.486.485.538', 'D12.776.124.790.651.538', 'D12.776.37... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
WNK2 modulates MEK1 activity through the Rho GTPase pathway. | WNK protein kinases form a kinase subfamily expressed in multi-cellular organisms and the human genome encodes four distinct WNK genes. Human WNK2 has been recently identified as a cell growth regulator that modulates activation of the ERK1/2 protein kinase and is epigenetically silenced in gliomas. Here we provide mec... | ['Cell Line', 'Enzyme Activation', 'Extracellular Signal-Regulated MAP Kinases', 'Gene Silencing', 'Humans', 'MAP Kinase Kinase 1', 'Phosphoserine', 'Protein-Serine-Threonine Kinases', 'Recombinant Proteins', 'p21-Activated Kinases', 'rac1 GTP-Binding Protein', 'rhoA GTP-Binding Protein'] | 18,593,598 | [['A11.251.210'], ['G02.111.263', 'G03.328'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['G05.308.203.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.565.100', 'D08.811.913.696.620.682.725.200.100', 'D12.644.360.440.100', 'D12.776.476.44... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Engaged patients, engaged partnerships: singles and partners dealing with an acute cardiac event. | A few studies examine patients' (and partners') individual and relational functioning after an acute cardiac event and no research focuses on the individual and relational factors associated with the patient's engagement in his/her disease management. The present study aimed at exploring these variables in male and fem... | ['Aged', 'Female', 'Heart Diseases', 'Humans', 'Interpersonal Relations', 'Male', 'Middle Aged', 'Patient Acceptance of Health Care', 'Patients', 'Spouses'] | 25,506,636 | [['M01.060.116.100'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['M01.060.116.630'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['M01.643'], ['F01.829.263.500.660', 'I01.880.853.150.500.670', 'M01.816']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The targeted delivery of doxorubicin with transferrin-conjugated block copolypeptide vesicles. | We previously investigated the intracellular trafficking properties of our novel poly(l-glutamate)60-b-poly(l-leucine)20 (E60L20) vesicles (EL vesicles) conjugated to transferrin (Tf). In this study, we expand upon our previous work by investigating the drug encapsulation, release, and efficacy properties of our novel ... | ['Cell Line, Tumor', 'Doxorubicin', 'Drug Delivery Systems', 'Humans', 'Hydrogen-Ion Concentration', 'Models, Theoretical', 'Peptides', 'Polyethylene Glycols', 'Solubility', 'Transferrin'] | 26,456,252 | [['A11.251.210.190', 'A11.251.860.180'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.599'], ['D12.644'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], [... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Intramedullary versus extramedullary tibial alignment guides in total knee arthroplasty. | The intramedullary alignment guide is superior to the extramedullary guide for preparation of the femur in total knee arthroplasty. However, there is controversy over which guide is more appropriate for the tibial sector. We retrospectively compared the accuracy of the intramedullary and extramedullary guides for tibia... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Knee', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tibia'] | 9,747,068 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Central effects of a local inflammation in three commonly used mouse strains with a different anxious phenotype. | As in humans, genetic background in rodents may influence a peculiar set of behavioural traits such as sensitivity to pain and stressors or anxiety-related behaviours. Therefore, we tested the hypothesis that mice with different genetic backgrounds [outbred (CD1), inbred (C57BL/6J) and hybrid (B6C3F1) adult male mice] ... | ['Analysis of Variance', 'Animals', 'Animals, Outbred Strains', 'Anxiety', 'Brain', 'Brain-Derived Neurotrophic Factor', 'Cytokines', 'Disease Models, Animal', 'Exploratory Behavior', "Freund's Adjuvant", 'Gene Expression Regulation', 'Hyperalgesia', 'Inflammation', 'Male', 'Maze Learning', 'Mice', 'Mice, Inbred Strain... | 21,624,397 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.284'], ['F01.470.132'], ['A08.186.211'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Primary anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma of the breast in a male patient. | Anaplastic large-cell lymphoma is an extremely rare lymphoma subtype. We describe the mammographic and ultrasonographic findings in a 51-year-old male patient who suffered from a palpable lump caused by this rare disease. | ['Anaplastic Lymphoma Kinase', 'Breast Neoplasms, Male', 'Humans', 'Lymphoma, Large-Cell, Anaplastic', 'Male', 'Middle Aged', 'Radiography', 'Receptor Protein-Tyrosine Kinases', 'Ultrasonography'] | 22,457,412 | [['D08.811.913.696.620.682.725.400.002', 'D12.776.543.750.630.002'], ['C04.588.180.260', 'C17.800.090.500.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480.750.399', 'C15.604.515.569.480.750.600', 'C20.683.515.761.480.750.399'], ['M01.060.116.630'], ['E01.370.350.700'], ['D08.811.913.696.620.682... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Shared decision making for hydroxyurea treatment initiation in children with sickle cell anemia. | Clinical trials have demonstrated hydroxyurea's efficacy in improving health outcomes for children with sickle cell anemia (SCA) who have medical complications. New NHLBI clinical guidelines will recommend offering hydroxyurea to young patients regardless of clinical severity. Shared decision making may be an effective... | ['Anemia, Sickle Cell', 'Antisickling Agents', 'Child', 'Clinical Decision-Making', 'Decision Making', 'Humans', 'Hydroxyurea', 'Parents', 'Physician-Patient Relations'] | 25,308,571 | [['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['D27.505.954.502.135'], ['M01.060.406'], ['E01.055'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.950.395'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['F01.829.401.650.675', ... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Nonsteroidal antiinflammatory drug toxicity monitoring and safety practices. | OBJECTIVE: Nonsteroidal antiinflammatory drug (NSAID) related gastrointestinal (GI) and renal adverse events are commonly reported. Although published guidelines recommend periodic laboratory monitoring, NSAID safety practices of physicians have not been investigated at a population level. We examined the associations ... | ['Adolescent', 'Adult', 'Adverse Drug Reaction Reporting Systems', 'Aged', 'Anti-Inflammatory Agents, Non-Steroidal', 'Drug Utilization Review', 'Environmental Monitoring', 'Epidemiological Monitoring', 'Gastrointestinal Diseases', 'Humans', 'Middle Aged', 'Retrospective Studies'] | 14,719,213 | [['M01.060.057'], ['M01.060.116'], ['E05.337.800.120', 'N02.421.668.320.120'], ['M01.060.116.100'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['N04.452.706.477.400', 'N04.761.879.300', 'N05.700.900.300'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.318.375', 'N06.850.520.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vivo passage of albumin from the aqueous humor into the lens. | PURPOSE: To determine if albumin, the major protein component of the aqueous humor, passes into the lens in vivo.METHODS: Rat albumin was covalently-labeled with Alexa 488 fluorophore, purified by gel permeation chromatography, then injected into the aqueous chamber of living rats. At 5 min postinjection, lenses were r... | ['Animals', 'Aqueous Humor', 'Biological Transport', 'Chromatography, High Pressure Liquid', 'Fluorescent Dyes', 'Gap Junctions', 'Hydrazines', 'Lens, Crystalline', 'Male', 'Microscopy, Confocal', 'Microscopy, Immunoelectron', 'Rats', 'Serum Albumin'] | 15,073,582 | [['B01.050'], ['A09.371.060.067.070', 'A12.207.270.040'], ['G03.143'], ['E05.196.181.400.300'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['A11.284.149.165.420.471'], ['D02.442'], ['A09.371.060.500'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.402.625', 'E05.595.402.625'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute myeloid leukemia and background radiation in an expanded case-referent study. | A case-referent study that investigated possible associations between environmental and occupational exposures and acute myeloid leukemia was performed on 86 cases and 172 referents, all of whom were living. Exposure information was obtained through a questionnaire mailed to each subject. An association was found betwe... | ['Acute Disease', 'Adult', 'Aged', 'Case-Control Studies', 'Environmental Exposure', 'Gamma Rays', 'Humans', 'Leukemia, Myeloid', 'Leukemia, Radiation-Induced', 'Middle Aged', 'Risk Factors', 'Sweden'] | 2,270,956 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N06.850.460.350'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['C04.557.337.650', 'C04.68... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acute effect of ozone exposure on daily mortality in seven cities of Jiangsu Province, China: No clear evidence for threshold. | BACKGROUND: Few multicity studies have addressed the health effects of ozone in China due to the scarcity of ozone monitoring data. A critical scientific and policy-relevant question is whether a threshold exists in the ozone-mortality relationship.METHODS: Using a generalized additive model and a univariate random-eff... | ['Air Pollutants', 'China', 'Cities', 'Environmental Exposure', 'Humans', 'Mortality', 'Ozone', 'Seasons'] | 28,231,551 | [['D27.888.284.101'], ['Z01.252.474.164'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['D01.362.670.600'], ['G01.910.645.661', 'G16.500.275.071.590'... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The electronic Psoriasis and Arthritis Screening Questionnaire (ePASQ): a sensitive and specific tool to diagnose psoriatic arthritis patients. | BACKGROUND: We report on an electronic version of the Psoriatic Arthritis Screening Questionnaire (ePASQ), a sensitive and specific tool for diagnosis of psoriatic arthritis (PsA) in patients with plaque psoriasis.OBJECTIVE: To validate the ePASQ against the original paper version.METHOD: The ePASQ scores 15 points on ... | ['Adult', 'Arthritis, Psoriatic', 'Female', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Prospective Studies', 'ROC Curve', 'Sensitivity and Specificity', 'Surveys and Questionnaires'] | 21,561,582 | [['M01.060.116'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['M... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Trends in research on energy balance supported by the National Cancer Institute. | Over the past decade, the body of research linking energy balance to the incidence, development, progression, and treatment of cancer has grown substantially. No prior NIH portfolio analyses have focused on energy balance within one institute. This portfolio analysis describes the growth of National Cancer Institute (N... | ['Biomedical Research', 'Energy Metabolism', 'Financing, Government', 'Health Behavior', 'Humans', 'National Cancer Institute (U.S.)', 'Neoplasms', 'Research Design', 'Research Support as Topic', 'United States'] | 23,498,109 | [['H01.770.644.145'], ['G03.295'], ['N03.219.521.346'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.409.418.750.600.650.496.150', 'N03.540.052.750.150', 'N03.540.348.500.500.600.650.496.150'], ['C04'], ['E05.581.500', 'H01.770.644.728'], ['N03.219.483.645'], ['Z01.107.567.875']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Incidence and pattern of liver involvement in haematological malignancies. | The incidence and pattern of liver involvement in 127 liver specimens (2 biopsy and 125 autopsy specimens) from cases of acute myelogenous leukaemia (25), chronic myelogenous leukaemia (7), acute lymphatic leukaemia (5), chronic lymphatic leukaemia (9), multiple myeloma (25), low-grade non-Hodgkin's lymphoma (25), high... | ['Antigens, Neoplasm', 'Hepatomegaly', 'Humans', 'Immunoenzyme Techniques', 'Immunophenotyping', 'Incidence', 'Leukemia', 'Leukemic Infiltration', 'Liver', 'Liver Neoplasms', 'Lymphoma, Non-Hodgkin', 'Multiple Myeloma', 'Organ Size'] | 9,842,637 | [['D23.050.285'], ['C06.552.416', 'C23.300.775.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['E01.370.225.812.447', 'E05.200.812.447', 'E05.478.594.450'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Control of human and animal platelet aggregation by a new prostacyclin analog. | The in vitro effects of ZK 36 374, a new chemically stable prostacyclin (PGI2) analog, on platelet aggregation were studied and compared to those of PGI2. Significantly lower concentrations of ZK 36 374, versus prostacyclin, were required to inhibit collagen and epinephrine-induced aggregation in human platelet-rich pl... | ['Adenosine Diphosphate', 'Animals', 'Cardiovascular Agents', 'Collagen', 'Dose-Response Relationship, Drug', 'Epinephrine', 'Epoprostenol', 'Humans', 'Iloprost', 'Male', 'Platelet Aggregation', 'Rabbits', 'Rats'] | 2,408,447 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['B01.050'], ['D27.505.954.411'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neurophysiological Evaluation of a Customizable ìECoG-based Wireless Brain Implant. | The number of implantable bidirectional neural interfaces available for neuroscientific research applications is still limited, despite the rapidly increasing number of customized components. We previously reported on how to translate available components into "ready-to-use" wireless implantable systems utilizing compo... | ['Animals', 'Brain', 'Electrocorticography', 'Evoked Potentials, Auditory', 'Neurophysiology', 'Prostheses and Implants', 'Sheep'] | 30,441,019 | [['B01.050'], ['A08.186.211'], ['E01.370.376.300.294', 'E01.370.405.245.431'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['H01.158.610.268', 'H01.158.782.562'], ['E07.695'], ['B01.050.150.900.649.313.500.380.791']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Short-term phytohaemagglutinin-activated mononuclear cells induce endothelial progenitor cells from cord blood CD34+ cells. | Endothelial progenitor cells (EPCs) were recently demonstrated to exist in human cord blood. Phytohaemagglutinin (PHA), a potent mitogen for mononuclear cells was used to induce EPCs from unsorted cord blood mononuclear cells (CBMCs). Adherent cells in clusters appeared approximately 24 h after CBMCs were cultured in p... | ['Antigens, CD34', 'Cell Differentiation', 'Cells, Cultured', 'Endothelial Growth Factors', 'Endothelium, Vascular', 'Fetal Blood', 'Fibronectins', 'Humans', 'Immunohistochemistry', 'Leukocytes, Mononuclear', 'Lymphokines', 'Mitogens', 'Phytohemagglutinins', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Rea... | 11,442,490 | [['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['G04.152'], ['A11.251'], ['D12.644.276.390', 'D12.776.467.390', 'D23.529.390'], ['A07.015.700.500', 'A10.272.491.355'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioactive furanocoumarins from the stems and leaves of Clausena hainanensis. | A new furanocoumarin, clauhainanin A (1), together with seven known furanocoumarins (2-8), were isolated from the stems and leaves of Clausena hainanensis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. Al... | ['Antineoplastic Agents', 'Cell Line, Tumor', 'Clausena', 'Furocoumarins', 'Humans', 'Molecular Structure', 'Plant Leaves', 'Plant Stems'] | 28,826,247 | [['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.650.940.800.575.912.250.875.216'], ['D03.383.663.283.446.794', 'D03.633.100.150.446.794', 'D03.633.300.770'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570', 'G02.466'], ['A18.024.812'], ['A18.024.937']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Which strategy for molecular probe design? An answer from the integration of spectroscopy and QM modeling. | With this study we show that the maturity reached by quantum-mechanical (QM) modeling has allowed a new analytical approach to the design of molecular probes. In this approach, the strategy is to integrate suited computational tools with multi-spectroscopic measurements to identify specific signals for the characteriza... | ['Anthracenes', 'Magnetic Resonance Spectroscopy', 'Molecular Probes', 'Quantum Theory', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ultraviolet'] | 20,532,298 | [['D02.455.426.559.847.117', 'D04.615.117'], ['E05.196.867.519'], ['D27.505.259.750', 'D27.720.470.530'], ['H01.671.579.800'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Microsatellite genotyping of carnation varieties. | A set of 11 sequence-tagged microsatellite markers for carnation (Dianthus caryophyllus) was developed using a DNA library enriched for microsatellites. Supplemented with three markers derived from sequence database entries, these were used to genotype carnation varieties using a semi-automated fluorescence-based appro... | ['Base Sequence', 'DNA Primers', 'Dianthus', 'Genotype', 'Microsatellite Repeats'] | 12,748,769 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B01.650.940.800.575.912.250.198.500.250.222'], ['G05.380'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Palladium-catalyzed synthesis of 2-alkenyl-3-arylindoles via a dual á-arylation strategy: formal synthesis of the antilipemic drug fluvastatin. | A new approach has been developed for the synthesis of substituted 2-alkenyl-3-arylindoles. The strategy comprises palladium-catalyzed dual á-arylation of TES-enol ethers of enones as the key step. This methodology results in products with very good yields and the regioselectivity is exclusive. We have also successfull... | ['Catalysis', 'Fatty Acids, Monounsaturated', 'Fluvastatin', 'Hypolipidemic Agents', 'Indoles', 'Palladium', 'Stereoisomerism'] | 26,384,042 | [['G02.130'], ['D10.251.355.325'], ['D03.633.100.473.305', 'D10.251.450.300'], ['D27.505.519.186.071', 'D27.505.954.557.500'], ['D03.633.100.473'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV. | BACKGROUND AND OBJECTIVES: Antiretrovirals are currently used for the treatment and prevention of HIV infection. However, poor adherence and low tolerability of some existing oral formulations can hinder their efficacy. Long-acting (LA) injectable nanoformulations could help address these complications by simplifying a... | ['Adolescent', 'Adult', 'Algorithms', 'Anti-HIV Agents', 'Computer Simulation', 'Female', 'HIV Infections', 'Humans', 'Injections, Intramuscular', 'Intestinal Absorption', 'Male', 'Middle Aged', 'Models, Biological', 'Nanomedicine', 'Nanostructures', 'Young Adult'] | 25,523,214 | [['M01.060.057'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['D27.505.954.122.388.077.088'], ['L01.224.160'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['G03.015... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
[All pedicle screws technique applied to the treatment of idiopathic scoliosis]. | OBJECTIVE: To Analyze the therapeutic efficacy of all pedicle screws technique applied to the treatment of idiopathic scoliosis and evaluate its safety.METHODS: From June 2002 to October 2005, 56 patients with idiopathic scoliosis were treated with all pedicle screws technique, including 11 males and 45 females, rangin... | ['Adolescent', 'Adult', 'Bone Screws', 'Child', 'Female', 'Humans', 'Internal Fixators', 'Male', 'Scoliosis', 'Tomography, X-Ray Computed'] | 19,108,417 | [['M01.060.057'], ['M01.060.116'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.370', 'E07.858.442.660.460', 'E07.858.690.725.460'], ['C05.116.900.800.875'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Entomologic fauna and its importance in the determination of the age of corpses]. | The authors summarize results of research conducted in 1990-1992, the aim of which was to test the accuracy of practical application of forensic entomology in medical practice. Based on the results of laboratory breeding of necrophagic Diptera collected from corpses and based on time characteristics of subsequent stage... | ['Animals', 'Cadaver', 'Coleoptera', 'Diptera', 'Forensic Medicine', 'Humans', 'Time Factors'] | 8,322,075 | [['B01.050'], ['C23.550.260.224'], ['B01.050.500.131.617.720.500.500.375'], ['B01.050.500.131.617.720.500.500.750'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.857']] | ['Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Diagnostic potential of puumala virus nucleocapsid protein expressed in Drosophila melanogaster cells. | Puumala virus (PUU) nucleocapsid protein (N) was expressed in insect cells by using the Drosophila Expression System (DES; Invitrogen BV, Groningen, The Netherlands). Stable transfectants were established by hygromycin B selection and showed continuous expression of the recombinant protein (DES-PUU-N) for at least 5 mo... | ['Animals', 'Antibodies, Viral', 'Cells, Cultured', 'Drosophila melanogaster', 'Drug Stability', 'Enzyme-Linked Immunosorbent Assay', 'Hantavirus', 'Hantavirus Infections', 'Hemorrhagic Fever with Renal Syndrome', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Latvia', 'Nucleocapsid', 'Nucleocapsid Proteins', 'Reco... | 10,834,996 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['A11.251'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['E05.916.330'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B04.820.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Sleep apnea syndrome caused by acromegalia and the treatment with a reduction plasty of the tongue. Case report. | Obstructive sleep apnea syndrome was every likely caused by an enlarged tongue in a 60-year-old man with acromegalia. The diagnosis was confirmed by polygraphic sleep recordings and by roentgenologic examination. The patient was treated with a tongue-reduction plasty which gave him good subjective relief and better sle... | ['Acromegaly', 'Airway Obstruction', 'Humans', 'Male', 'Middle Aged', 'Sleep Apnea Syndromes', 'Tongue'] | 7,099,578 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['C08.618.846.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C08.618.085.852', 'C10.886.425.800.750'], ['A03.556.500.885', 'A14.549.885']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Software-aided automatic laser optoporation and transfection of cells. | Optoporation, the permeabilization of a cell membrane by laser pulses, has emerged as a powerful non-invasive and highly efficient technique to induce transfection of cells. However, the usual tedious manual targeting of individual cells significantly limits the addressable cell number. To overcome this limitation, we ... | ['Animals', 'Automation, Laboratory', 'CHO Cells', 'Cell Culture Techniques', 'Cell Line', 'Cell Membrane', 'Cricetulus', 'Lasers', 'Transfection'] | 26,053,047 | [['B01.050'], ['E05.064', 'J01.897.104.416'], ['A11.251.210.200', 'A11.436.155'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210'], ['A11.284.149'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['E07.632.490', 'E07.710.520'], ['E05.393.350.810', 'G05.728.860']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Analysis of animal weight gains in chronic toxicity studies. | The growth pattern of an animal or group of animals during a chronic toxicity study can be used in a a number of ways. Perhaps the most important uses are for prediction of future weights and as evidence of toxic effects. In this paper a model for animal weight gain is constructed and analyzed. Tests and interval estim... | ['Animals', 'Benzidines', 'Body Weight', 'Female', 'Male', 'Mathematics', 'Mice', 'Models, Biological', 'Species Specificity', 'Time Factors', 'Toxicology'] | 7,230,278 | [['B01.050'], ['D02.455.426.559.389.185.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['H01.548'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395'], ['G16.824'], ['G01.910.857'], ['H01.158.891', 'H02.884']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of add-on l-methylfolate therapy in a complex psychiatric illness with MTHFR C677 T genetic polymorphism. | The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism. Many studies have demonstrated an association between MTHFR C677 T variant with depression, schizophrenia and bipolar disorder as one of them being comorbid to other. This has justified the use of folate supplement in p... | ['Adult', 'Antidepressive Agents', 'Antipsychotic Agents', 'Aripiprazole', 'Bipolar Disorder', 'Depressive Disorder, Treatment-Resistant', 'Drug Therapy, Combination', 'Fluoxetine', 'Humans', 'Lithium Compounds', 'Male', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'Obsessive-Compulsive Disorder', 'Polymorphism, Gen... | 27,520,898 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.383.606.170', 'D03.633.100.810.835.122'], ['F03.084.500'], ['F03.600.300.388'], ['E02.319.310'], ['D02.092.831.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.510... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new distal arthrogryposis syndrome characterized by plantar flexion contractures. | The distal arthrogryposis (DA) syndromes are a distinct group of disorders characterized by contractures of two or more different body areas. More than a decade ago, we revised the classification of DAs and distinguished several new syndromes. This revision has facilitated the identification of five genes (i.e., TNNI2,... | ['Adolescent', 'Adult', 'Aged', 'Arthrogryposis', 'Child, Preschool', 'Contracture', 'Female', 'Genes, Dominant', 'Humans', 'Male', 'Middle Aged', 'Pedigree', 'Phenotype', 'Syndrome'] | 17,103,435 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C05.550.150', 'C05.651.102', 'C05.660.077', 'C16.131.621.077'], ['M01.060.406.448'], ['C05.550.323', 'C05.651.197'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.393.673'], ['G05.695'], [... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alcohol consumption shows a J-shaped association with lower urinary tract symptoms in the general screening population. | PURPOSE: Controversial and contradictory data on the association between alcohol consumption and lower urinary tract symptoms are currently available in the literature. In this study we determined the association between alcohol consumption and lower urinary tract symptoms, including voiding and storage symptoms, in a ... | ['Adult', 'Aged', 'Alcohol Drinking', 'Cross-Sectional Studies', 'Humans', 'Lower Urinary Tract Symptoms', 'Male', 'Mass Screening', 'Middle Aged'] | 22,341,268 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.942.343'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expanding the Utilization of the Osteocutaneous Radial Forearm Free Flap beyond Mandibular Reconstruction. | Background The osteocutaneous radial forearm free flap (OCRFFF) for mandibular reconstruction has been well described. Despite this flap's utility in the repair of such defects, the indications for the OCRFFF have continued to expand in recent years. The advantages of the OCRFFF allow for a high degree of versatility i... | ['Adult', 'Aged', 'Carcinoma, Squamous Cell', 'Female', 'Forearm', 'Free Tissue Flaps', 'Graft Survival', 'Humans', 'Male', 'Mandible', 'Mandibular Neoplasms', 'Mandibular Reconstruction', 'Middle Aged', 'Osteotomy', 'Radius', 'Reconstructive Surgical Procedures', 'Retrospective Studies', 'Tissue and Organ Harvesting',... | 26,848,567 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A01.378.800.585'], ['A10.850.710.500', 'E07.862.710.500'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['C04.588.149.721.450.583', 'C05.116.231.754.450.583',... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical profile and aetiology of optic neuritis in Hospital Universiti Sains Malaysia--5 years review. | Although few studies concerning optic neuritis (ON) in Asian countries have been reported, there is no report about ON in Malaysia particularly within the Malay population. We aimed to determine the clinical manifestation, visual outcome and aetiology of ON in Malays, and discussed the literature of ON studies in other... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Female', 'Hospitals, Teaching', 'Humans', 'Malaysia', 'Male', 'Middle Aged', 'Optic Neuritis', 'Retrospective Studies'] | 22,822,635 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.487'], ['M01.060.116.630'], ['C10.292.700.550', 'C11.640.576'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Optoelectronic tuning of organoborylazadipyrromethenes via effective electronegativity at the metalloid center. | Organoborylazadipyrromethenes were synthesized from free base and fluoroborylazadipyrromethenes and characterized with regard to their structural and electronic properties. B-N bond lengths, along with photophysical and redox behavior, appear dependent on the effective electronegativity at the boron atom as tuned by it... | ['Alkenes', 'Aza Compounds', 'Boron', 'Coordination Complexes', 'Crystallography, X-Ray', 'Electrochemistry', 'Light', 'Molecular Structure', 'Pyrroles'] | 24,533,769 | [['D02.455.326.271'], ['D02.145'], ['D01.268.513.500'], ['D01.234', 'D02.257'], ['E05.196.309.742.225'], ['H01.181.529.307'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G02.111.570', 'G02.466'], ['D03.383.129.578']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypoxia of the growing liver accelerates regeneration. | BACKGROUND: After portal vein ligation of 1 side of the liver, the other side regenerates at a slow rate. This slow growth may be accelerated to rapid growth by adding a transection between the 2 sides, i.e., performing portal vein ligation and parenchymal transection. We found that in patients undergoing portal vein l... | ['Animals', 'Cell Hypoxia', 'Hepatectomy', 'Ligation', 'Liver', 'Liver Regeneration', 'Male', 'Models, Animal', 'Portal Vein', 'Rats', 'Rats, Wistar'] | 27,436,690 | [['B01.050'], ['G03.197.300', 'G04.270.300'], ['E04.210.556'], ['E04.426'], ['A03.620'], ['G10.261.475', 'G16.762.468'], ['E05.598'], ['A07.015.908.670.567'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Empirical likelihood method for non-ignorable missing data problems. | Missing response problem is ubiquitous in survey sampling, medical, social science and epidemiology studies. It is well known that non-ignorable missing is the most difficult missing data problem where the missing of a response depends on its own value. In statistical literature, unlike the ignorable missing data probl... | ['Acquired Immunodeficiency Syndrome', 'Biometry', 'CD4 Lymphocyte Count', 'Clinical Trials as Topic', 'Data Interpretation, Statistical', 'Humans', 'Likelihood Functions', 'Models, Statistical', 'Research Design'] | 27,647,436 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['E05.318.740.225', 'N06.850.505.200'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Lung cancer among Chinese females in Singapore 1968-1992: time trends, dialect group differences and implications for aetiology. | BACKGROUND: Chinese females are distinguished internationally as having relatively high lung cancer incidence rates despite a low prevalence of cigarette smoking. In Singapore, this population comprises several dialect groups which have origins in different regions in China, each with its own traditional cultural pract... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Small Cell', 'Carcinoma, Squamous Cell', 'China', 'Cohort Studies', 'Female', 'Humans', 'Incidence', 'Linguistics', 'Lung Neoplasms', 'Middle Aged', 'Registries', 'Singapore', 'Time Factors'] | 9,602,394 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.380'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['Z01.252.474.164'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
[Challenge provocation tests and non-specific bronchial hyperactivity in occupational asthma]. | The aim of the study is to determine the interest of realistic challenge (nasal and bronchial) in occupational respiratory symptoms appearing during work. 75 patients were included in the study. The protocol included prick tests, measuring total and specific IgE, spirometry and metacholine test to assess bronchial hype... | ['Asthma', 'Bronchial Provocation Tests', 'Female', 'Humans', 'Male', 'Nasal Provocation Tests', 'Occupational Diseases'] | 2,487,325 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E01.370.386.700.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.386.550'], ['C24']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioavailability of trace metals and rare earth elements (REE) from the tropical soils of a coal mining area. | In order to assess the environmental risks related to mining activities in Southern Brazil, the transfer of trace metals and rare earth elements (REE) from soils to soybeans was evaluated in a U-rich area associated with coal mining. In some samples, As, Ba, Co, Cu and Ni were higher than the guidelines proposed by the... | ['Biological Availability', 'Brazil', 'Coal Mining', 'Environmental Monitoring', 'Metals', 'Mining', 'Soil', 'Soil Pollutants', 'Trace Elements'] | 31,836,238 | [['G03.787.151', 'G07.690.725.129'], ['Z01.107.757.176'], ['J01.576.655.875.500.500'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.552'], ['J01.576.655.875.500'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.888.284.756'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. | Immunotherapy holds promise for multiple myeloma (MM) patients but little is known about how MM-induced immunosuppression influences response to therapy. Here, we investigated the impact of disease progression on immunotherapy efficacy in the Vk*MYC mouse model. Treatment with agonistic anti-CD137 (4-1BB) mAbs efficien... | ['4-1BB Ligand', 'Animals', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Antineoplastic Agents', 'CD8-Positive T-Lymphocytes', 'Disease Models, Animal', 'Immunologic Factors', 'Immunotherapy', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Multiple Myeloma', 'T-Lymphocytes, Regulatory'] | 31,194,697 | [['D12.644.276.374.750.065', 'D12.776.395.192', 'D12.776.467.374.750.065', 'D12.776.543.550.194', 'D23.529.374.750.065'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D27.505.954.248'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The assessment of pain sensation during local anesthesia using a computerized local anesthesia (Wand) and a conventional syringe. | PURPOSE: The purpose of this study was to compare the behavior reaction of children who received local anesthesia with a conventional syringe injection and a computerized device (Wand).METHODS: One hundred and two children ages 3 to 10 years were selected for this study. In 1 group there were 55 children between the ag... | ['Anesthesia, Dental', 'Anesthesia, Local', 'Anesthetics, Local', 'Child', 'Child Behavior', 'Child, Preschool', 'Cross-Over Studies', 'Crying', 'Equipment Design', 'Facial Expression', 'Female', 'Humans', 'Injections', 'Male', 'Movement', 'Nerve Block', 'Pain', 'Pain Measurement', 'Syringes'] | 14,528,773 | [['E03.155.141', 'E06.045'], ['E03.155.086.231'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['F01.145.209.530.258', 'F01.525.200.310.300'], ['E05.320'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Socioeconomic and regional differences in active transportation in Brazil. | OBJECTIVE: To present national estimates regarding walking or cycling for commuting in Brazil and in 10 metropolitan regions.METHODS: By using data from the Health section of 2008's Pesquisa Nacional por Amostra de Domic?lio (Brazil's National Household Sample Survey), we estimated how often employed people walk or cyc... | ['Adolescent', 'Adult', 'Aged', 'Bicycling', 'Brazil', 'Female', 'Humans', 'Male', 'Middle Aged', 'Rural Population', 'Sex Factors', 'Socioeconomic Factors', 'Transportation', 'Urban Population', 'Walking', 'Young Adult'] | 27,355,465 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['I03.450.642.845.140'], ['Z01.107.757.176'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N01.600.725'], ['N05.715.350.675', 'N06.850.490.875'], ['I01.880.853.996', 'N01.824'], ['J01.937'], ['N01.600.900'], ['G11.427.410.568.900', 'G11.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice. | Angiostatin and endostatin are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis in vivo and tumor growth in mice. However, tumor shrinkage requires chronic delivery of large doses of these proteins. Here we report synergistic antitumor activity and survival of animals when these fa... | ['Angiogenesis Inhibitors', 'Angiostatins', 'Animals', 'Antineoplastic Agents', 'Blotting, Western', 'Cell Division', 'Cell Separation', 'Cell Survival', 'Collagen', 'Down-Regulation', 'Drug Combinations', 'Endostatins', 'Female', 'Flow Cytometry', 'Gene Transfer Techniques', 'Genetic Therapy', 'Genetic Vectors', 'Gree... | 11,237,675 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D08.622.610.500', 'D12.644.276.100.450.500', 'D12.776.124.790.223.580.500', 'D12.776.377.715.182.580.500', 'D12.776.467.100.450.500', 'D12.776.811.243.610.500', 'D23.529.100.450.500'], ['B01.050'], ['D27.505.954.248'], ['E05.196.401.143',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. | Human melanoma MZ2-MEL expresses several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTL). Some of these antigens are encoded by genes MAGE-1, MAGE-3, and BAGE, which are expressed in a large fraction of tumors of various histological types but are silent in normal adult tissues with th... | ['Amino Acid Sequence', 'Animals', 'Antigens, Neoplasm', 'Base Sequence', 'Cell Line, Transformed', 'Chlorocebus aethiops', 'DNA, Complementary', 'DNA, Neoplasm', 'Epitopes', 'Fetus', 'Gene Expression Regulation, Neoplastic', 'HLA-C Antigens', 'HeLa Cells', 'Humans', 'Melanoma', 'Melanoma-Specific Antigens', 'Molecular... | 7,544,395 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.285'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.172'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D13.444.308.425'], ['D23.05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study. | PURPOSE: To investigate risk factors for disc hemorrhage detection in the Low-Pressure Glaucoma Treatment Study.DESIGN: Cohort of a randomized, double-masked, multicenter clinical trial.METHODS: Low-Pressure Glaucoma Treatment Study patients with at least 16 months of follow-up were included. Exclusion criteria include... | ['Antihypertensive Agents', 'Blood Pressure', 'Brimonidine Tartrate', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Humans', 'Intraocular Pressure', 'Low Tension Glaucoma', 'Male', 'Middle Aged', 'Optic Disk', 'Proportional Hazards Models', 'Quinoxalines', 'Retinal Hemorrhage', 'Risk Factors', 'Timolol'] | 24,513,094 | [['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.633.100.857.070'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Direct cost assessments in subjects with seasonal allergic rhinitis living in Ankara, Turkey. | The characteristics of seasonal allergic rhinitis (SAR) including the severity at initial presentation and cost estimates are not established for Turkey. The aim of this study was to document the clinical features and direct cost of subjects with SAR when diagnosed and followed according to international treatment guid... | ['Adult', 'Direct Service Costs', 'Drug Costs', 'Female', 'Humans', 'Male', 'Poaceae', 'Pollen', 'Prospective Studies', 'Rhinitis, Allergic, Seasonal', 'Severity of Illness Index', 'Treatment Outcome', 'Turkey'] | 15,176,495 | [['M01.060.116'], ['N03.219.151.400.325', 'N05.300.375.250'], ['N03.219.151.400.350', 'N05.300.375.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.822'], ['A18.024.249.500.249.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C08.46... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Supporting students undertaking the Specialist Practitioner Qualification in District Nursing. | The ever-evolving role of the Specialist Practitioner Qualified District Nurse (SPQDN) presents an increasing number of challenges for Practice Teachers and mentors in preparing SPQDN students for the elevated level clinical and transformational leadership necessary to ensure high-quality patient care. The daily challe... | ['Certification', 'Community Health Nursing', 'Education, Nursing, Baccalaureate', 'Humans', 'Mentors', 'State Medicine', 'Students, Nursing', 'United Kingdom'] | 29,091,505 | [['N03.706.110.120', 'N05.700.200.190'], ['H02.478.676.150', 'N02.421.143.150'], ['I02.358.462.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.395'], ['N03.349.550.902', 'N03.858'], ['M01.848.769.685'], ['Z01.542.363']] | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Selective Progesterone Receptor Modulators for the Treatment of Uterine Leiomyomas. | Uterine leiomyomas have drawn much attention since being described more than 200 years ago. These common benign uterine tumors often present with prolonged menstrual bleeding, pelvic pressure, and reproductive disorders and pose a true financial burden on health care systems all over the world. Over the past few decade... | ['Female', 'Gonadotropin-Releasing Hormone', 'Humans', 'Leiomyoma', 'Norpregnadienes', 'Receptors, Progesterone', 'Uterine Neoplasms'] | 28,697,115 | [['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.450'], ['D04.210.500.668.651.443'], ['D12.776.826.750.765'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.93... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. | UNLABELLED: Dual-isotope imaging can allow simultaneous assessment of brain perfusion using a 99mTc-labeled tracer and neurotransmission using an 123I-labeled tracer. However, the images are affected by scatter, cross talk, attenuation, distance-dependent collimator response (DCR), and partial-volume effect. We determi... | ['Alzheimer Disease', 'Benzamides', 'Brain', 'Cerebellum', 'Cerebral Cortex', 'Cerebrovascular Circulation', 'Corpus Callosum', 'Humans', 'Iodine Radioisotopes', 'Monte Carlo Method', 'Neural Networks, Computer', 'Parkinson Disease', 'Phantoms, Imaging', 'Putamen', 'Pyrrolidines', 'Radiopharmaceuticals', 'Sensitivity a... | 11,216,530 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['A08.186.211'], ['A08.186.211.132.810.428.200'], ['A08.186.211.200.885.287.500'], ['G09.330.100.159'], ['A08.186.211.200.885.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A novel distal enhancer mediates cytokine induction of mouse RANKl gene expression. | Chronic inflammatory states are associated with increased bone loss. This increase is often linked to an elevation in receptor activator of nuclear factor-kappaB ligand (RANKL), a TNFalpha-like factor essential to osteoclast formation. In this study, we document the ability of IL-6 in combination with IL-6 soluble rece... | ['Animals', 'Antineoplastic Agents', 'Blotting, Western', 'Cell Line', 'Chromatin Immunoprecipitation', 'Colforsin', 'Cyclic AMP Response Element-Binding Protein', 'Enhancer Elements, Genetic', 'Gene Expression Regulation', 'Interleukin-6', 'Mice', 'Oncostatin M', 'Polymerase Chain Reaction', 'Protein Binding', 'RANK L... | 19,880,655 | [['B01.050'], ['D27.505.954.248'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['E05.393.170', 'E05.478.605.160'], ['D02.455.849.291.300'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.36... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative studies on surface hydrophobicity of streptococcal strains of groups A, B, C, D and G. | Cell surface hydrophobicity of group A, B, C, D and G streptococcal strains has been studied and compared in a new test based on the fact that the degree of bacterial aggregation in ammonium sulphate depends on amphiphilic surface antigens. M-positive group A strains showing good growth in normal human blood aggregated... | ['Ammonium Sulfate', 'Hydrogen-Ion Concentration', 'Streptococcus', 'Surface Properties', 'Temperature'] | 6,726,181 | [['D01.625.062.374', 'D01.875.800.800.850.050'], ['G02.300'], ['B03.353.750.737.872', 'B03.510.400.800.872', 'B03.510.550.737.872'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Biomechanical study of the extensor carpi ulnaris as a dynamic wrist stabilizer. | PURPOSE: To investigate the dynamic stabilizing effect of the extensor carpi ulnaris (ECU) on the distal radioulnar joint (DRUJ) and the ulnocarpal joint in a simulated model of triangular fibrocartilage complex (TFCC) injury.METHODS: Using 8 fresh-frozen cadavers, we fixed the humerus and ulna at 90° of elbow flexion,... | ['Aged, 80 and over', 'Biomechanical Phenomena', 'Cadaver', 'Forearm', 'Humans', 'Joint Instability', 'Ligaments, Articular', 'Pronation', 'Radius', 'Supination', 'Triangular Fibrocartilage', 'Ulna'] | 23,123,149 | [['M01.060.116.100.080'], ['G01.154.090', 'G01.374.089'], ['C23.550.260.224'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.521'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['G11.427.410.698.840'], ['A02.835.232.087.090.700'], ['G11.427.410.698.920'], ['A02.165.308.800', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Management of renal-vein perforation during a challenging percutaneous nephrolithotomy. | A 54-year-old man with complex urinary anatomy as the result of previous surgery sustained a renal-vein injury during percutaneous nephrolithotomy for a staghorn calculus with a blood loss of 1.5 L. He was managed with antibiotics, bed rest, heparin, and a 28F nephrostomy catheter, which was withdrawn gradually as the ... | ['Follow-Up Studies', 'Hemostasis, Surgical', 'Humans', 'Kidney', 'Kidney Calculi', 'Male', 'Middle Aged', 'Nephrostomy, Percutaneous', 'Renal Veins', 'Risk Assessment', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 16,053,363 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E02.520.490', 'E04.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.600.500', 'C12.777.967.249.500', 'C12.777.967.500.503', 'C13.351.968.419.600.500', 'C13.351.968.967.249.500', 'C13.351.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.