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Clinical role of soluble adhesion molecules during immunotherapy for perennial allergic rhinitis. | BACKGROUND: Soluble forms of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) have recently been identified in serum samples from atopic patients, but their clinical significance in the treatment of allergic diseases remains to be established.OBJECTIVE: To study the clinical r... | ['Adult', 'Female', 'Humans', 'Immunotherapy', 'Intercellular Adhesion Molecule-1', 'Male', 'Middle Aged', 'Rhinitis, Allergic, Perennial', 'Vascular Cell Adhesion Molecule-1'] | 9,440,779 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['D12.776.395.550.200.450', 'D12.776.543.550.200.450', 'D23.050.301.350.450'], ['M01.060.116.630'], ['C08.460.799.315.500', 'C08.674.453.500', 'C09.603.799.315.500', 'C20.543.480.680.443.500'], ['D12.776.395.550.200.920', 'D12.776.5... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes. | BACKGROUND: Acute liver failure after major surgical procedures is associated with a high risk of multiple organ failure, including acute renal failure. The optimal time to initiate renal replacement therapy for acute renal failure is controversial because of the poor overall clinical outcomes.STUDY DESIGN: From July 2... | ['Acute Kidney Injury', 'Female', 'Humans', 'Liver Failure, Acute', 'Male', 'Middle Aged', 'Postoperative Complications', 'Renal Dialysis', 'Retrospective Studies', 'Treatment Outcome'] | 17,660,073 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.308.500.750'], ['M01.060.116.630'], ['C23.550.767'], ['E02.870.300', 'E02.912.800'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.8... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A host-vector system for an Arthrobacter species. | An efficient host-vector system has been developed for an industrial strain of Arthrobacter sp. (NRRL B3728)used for glucose isomerase production. Protoplasts of Arthrobacter were generated by treating the cells with 0.5 mg lysozyme ml(-1) for 60 min in a solution containing 0.5 M-sucrose. Around 30% of the protoplasts... | ['Arthrobacter', 'DNA Restriction Enzymes', 'DNA, Bacterial', 'Genetic Vectors', 'Mutation', 'Plasmids'] | 2,846,755 | [['B03.510.024.850.050', 'B03.510.460.400.400.049.074'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.212'], ['G05.360.337'], ['G05.365.590'], ['G05.360.600']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. | Inhibitors of regeneration in myelin, such as myelin-associated glycoprotein (MAG), play an important role in preventing regeneration after CNS injury. Elevation of cAMP, either with dibutyryl-cAMP (db-cAMP) or by priming with a variety of neurotrophins, overcomes inhibition by MAG and myelin. However, activation of cA... | ["3',5'-Cyclic-AMP Phosphodiesterases", 'Animals', 'Brain-Derived Neurotrophic Factor', 'Bucladesine', 'CHO Cells', 'Cells, Cultured', 'Cricetinae', 'Cyclic AMP', 'Cyclic Nucleotide Phosphodiesterases, Type 4', 'Enzyme Inhibitors', 'Mitogen-Activated Protein Kinase Kinases', 'Mitogen-Activated Protein Kinases', 'Mutati... | 14,684,879 | [['D08.811.277.352.640.150', 'D12.644.360.008', 'D12.776.476.008'], ['B01.050'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['A11.251.210.200', 'A11.436.155'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychogenic paraplegia in a patient with normal electrophysiologic findings. | STUDY DESIGN: A case report of psychogenic paraplegia following a motor vehicle accident was clinically diagnosed using median (MN) and posterior tibial nerves (PTN) somatosensory evoked potentials (SSEPs).OBJECTIVE: To report an unusual case of paraplegia in spite of normal electrophysiological and non-compromising ra... | ['Accidents, Traffic', 'Adult', 'Diagnosis, Differential', 'Electromyography', 'Evoked Potentials, Somatosensory', 'Female', 'Humans', 'Neurologic Examination', 'Paraplegia', 'Psychophysiologic Disorders', 'Reference Values', 'Stress, Psychological'] | 11,781,866 | [['N06.850.135.392'], ['M01.060.116'], ['E01.171'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.376.550', 'E01.370.600.550'], ['C10.597.622.669', 'C23.888.592.636.637'], ['C23.888.592.700'], ['E05.978.810'], ['F01.145... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ATP-induced shrinkage of DNA with MukB protein and the MukBEF complex of Escherichia coli. | Fluorescence microscopic observation of individual T4 DNA molecules revealed that the MukBEF complex (bacterial condensin) and its subunit, the MukB (a member of the SMC [structural maintenance of chromosomes] superfamily) homodimer, of Escherichia coli markedly shrunk large DNA molecules in the presence of hydrolyzabl... | ['Adenosine Triphosphatases', 'Chromosomal Proteins, Non-Histone', 'DNA, Bacterial', 'DNA-Binding Proteins', 'Escherichia coli', 'Escherichia coli Proteins', 'Microscopy, Fluorescence', 'Multiprotein Complexes', 'Repressor Proteins'] | 18,326,568 | [['D08.811.277.040.025'], ['D12.776.660.235', 'D12.776.664.235'], ['D13.444.308.212'], ['D12.776.260'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['E01.370.350.515.458', 'E05.595.458'], ['D05.500'], ['D12.776.260.703', 'D12.776.930.780']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Degradation of P-glycoprotein by pristimerin contributes to overcoming ABCB1-mediated chemotherapeutic drug resistance in vitro. | ABCB1 (P-glycoprotein, ABCB1/MDR1) is one of the major members of the ABC transporters linked to MDR in cancer cells. In this study, we observed that pristimerin, a natural triterpenoid, potently decreased P-gp in a dose-dependent manner in both drug-resistant KBv200 and stable transfected HEK293/ABCB1 cell lines. More... | ['ATP Binding Cassette Transporter, Subfamily B', 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Cell Line, Tumor', 'Cells, Cultured', 'Doxorubicin', 'Drug Resistance, Multiple', 'Drug Resistance, Neoplasm', 'HEK293 Cells', 'Humans', 'Proteolysis', 'Triterpenes'] | 27,840,996 | [['D12.776.157.530.100.075', 'D12.776.157.530.450.074.500.500.250', 'D12.776.395.550.020.400', 'D12.776.543.550.192.400', 'D12.776.543.585.100.200', 'D12.776.543.585.450.074.500.500.250'], ['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frequent and variable abnormalities in p14 tumor suppressor gene in glioma cell lines. | Ten glioma cell lines were examined for abnormalities of exon 1beta of the p14 gene and then for abnormalities of the entire p14 gene with the use of previous findings of other exons. Abnormalities of exon 1beta and the entire p14 gene were detected in eight of ten cases: homozygous deletion of the entire gene in six c... | ['Adult', 'Aged', 'Base Sequence', 'Blotting, Northern', 'Blotting, Southern', 'Blotting, Western', 'Brain Neoplasms', 'Cell Line, Tumor', 'Female', 'Gene Expression', 'Glioma', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization, Fluorescence', 'Male', 'Middle Aged', 'Proto-Oncogene Proteins c-mdm2', 'RNA, Messen... | 18,415,661 | [['M01.060.116'], ['M01.060.116.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.6... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Audiovisual interactions depend on context of congruency. | In this study, we addressed how the particular context of stimulus congruency influences audiovisual interactions. We combined an audiovisual congruency task with a proportion-of-congruency manipulation. In Experiment 1, we demonstrated that the perceived duration of a visual stimulus is modulated by the actual duratio... | ['Adolescent', 'Adult', 'Attention', 'Auditory Perception', 'Discrimination, Psychological', 'Female', 'Humans', 'Male', 'Pattern Recognition, Visual', 'Time Perception', 'Young Adult'] | 22,160,743 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104.214'], ['F02.463.593.071', 'G07.888.125'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.463.593.857'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Five cited for innovative community health programs. Hospitals, health systems form community partnerships. | The American Hospital Association awarded recognition to five of the nation's most innovative hospitals and health systems. See how the five hospitals created award-winning community service programs. | ['American Hospital Association', 'Awards and Prizes', 'Community Health Services', 'Community-Institutional Relations', 'Hospitals, Community', 'Humans', 'Organizational Innovation', 'United States'] | 10,177,645 | [['N03.540.828.540.080'], ['K01.150'], ['N02.421.143'], ['N04.452.822.210'], ['N02.278.421.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.610'], ['Z01.107.567.875']] | ['Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Percutaneous retrograde tibial access in the endovascular treatment of acute limb ischaemia: a case report. | The utilization of a retrograde tibial approach in lower limb endovascular therapy has been described in the published literature. In this article we report our recent experience in order to highlight this valuable and under-utilised technique, which was successful in a difficult case where a conventional approach fail... | ['Acute Disease', 'Aged', 'Angiography, Digital Subtraction', 'Angioplasty, Balloon', 'Arterial Occlusive Diseases', 'Constriction, Pathologic', 'Humans', 'Ischemia', 'Lower Extremity', 'Male', 'Popliteal Artery', 'Tibial Arteries', 'Treatment Outcome'] | 17,588,783 | [['C23.550.291.125'], ['M01.060.116.100'], ['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['C14.907.137'], ['C23.300.287'], ['B01.050.150.900.64... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Local perceptions, RUSLEFAC mapping, and field results: the sediment budget of cocagne river, new brunswick, Canada. | Erosion and sedimentation in water courses represent a major and costly problem everywhere on the planet. Perception of local actors of the state of the river can be a useful source of information to document the river's changes. The main objective of this study consists of understanding how multiple data sources can b... | ['Conservation of Natural Resources', 'Ecosystem', 'Environmental Monitoring', 'Geologic Sediments', 'Models, Theoretical', 'New Brunswick', 'Perception', 'Rivers', 'Soil'] | 25,392,017 | [['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.330', 'G16.500.320'], ['E05.599'], ['Z01.107.567.176.494'], ['F02.463.593'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Cost-effectiveness of rituximab versus azathioprine for maintenance treatment in antineutrophil cytoplasmic antibody-associated vasculitis. | OBJECTIVES: Rituximab was proven superior to azathioprine for maintenance treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The high cost of rituximab might, however, limit its routine use. This study determined the cost-effectiveness of intravenous rituximab (5 x 500 mg until month 1... | ['Adolescent', 'Adult', 'Aged', 'Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis', 'Antibodies, Antineutrophil Cytoplasmic', 'Azathioprine', 'Cost-Benefit Analysis', 'Female', 'Humans', 'Maintenance Chemotherapy', 'Male', 'Middle Aged', 'Prospective Studies', 'Quality of Life', 'Rituximab', 'Young Adult'] | 31,162,031 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C14.907.940.897.249', 'C20.111.193'], ['D12.776.124.486.485.114.323.190', 'D12.776.124.790.651.114.323.190', 'D12.776.377.715.548.114.323.190', 'D23.101.050'], ['D02.886.759.111', 'D03.633.100.759.570.090', 'D13.570.900.111'], ['N03.219.151.125'], ['B01.050.150.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Bioactive rosette nanotube-hydroxyapatite nanocomposites improve osteoblast functions. | Inspired from biological systems, small synthetic organic molecules expressing the hydrogen bonding arrays of the DNA bases guanine and cytosine were prepared, and their self-assembly into rosette nanotubes (RNTs) was investigated. Due to their unique biological, physicochemical, and mechanical properties, RNTs could s... | ['Alkaline Phosphatase', 'Animals', 'Biocompatible Materials', 'Calcium', 'Cell Adhesion', 'Cell Count', 'Cell Death', 'Cell Shape', 'Collagen', 'Compressive Strength', 'Durapatite', 'Fibroblasts', 'Humans', 'Materials Testing', 'Microscopy, Fluorescence', 'Nanocomposites', 'Nanotubes', 'Osteoblasts', 'Polyhydroxyethyl... | 22,530,958 | [['D08.811.277.352.650.035'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.022'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.146'], ['G04.320'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G01.374.180'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Access to Justice in Health Matters: An Analysis Based on the Monitoring Mechanisms of the Inter-American System. | This article analyzes how states are complying with their periodic reporting obligations under the Protocol of San Salvador (PSS) in one specific area: access to justice as a key component of the right to health. The sources of information for this analysis are seven reports submitted by the States parties, together wi... | ['Delivery of Health Care', 'Global Health', 'Government', 'Human Rights', 'Humans', 'Latin America', 'Patient Rights', 'Social Justice', 'Social Responsibility'] | 30,008,562 | [['N04.590.374', 'N05.300'], ['H02.403.371', 'N01.400.337'], ['I01.409', 'N03.540.348'], ['I01.880.604.473', 'N03.706.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.424'], ['I01.880.604.473.650', 'N03.706.437.650'], ['I01.880.604.473.700', 'K01.752.566.479.830.750', 'N03.706.437.700', 'N05.350.958.75... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Humanities [K]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
[Methods for the demonstration of the basal membrane of the glomerular capillaries]. | Author for the demonstration of the basal membrane of the glomerular capillaries recommends oxidation with periodic-acid followed by treatment with potassium-metabisulfite and staining with resorcin-fuchsin, or impregnation with silver-nitrate solution in sodium borat. | ['Basement Membrane', 'Capillaries', 'Histological Techniques', 'Humans', 'Kidney Glomerulus'] | 362,174 | [['A10.272.220', 'A10.615.179'], ['A07.015.461.165'], ['E01.370.225.750', 'E05.200.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453.324.359', 'A05.810.453.736.520']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. | To evaluate the inhibitory effects of trimethoprim and sulfamethoxazole on cytochrome P450 (P450) isoforms, selective marker reactions for CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 were examined in human liver microsomes and recombinant CYP2C8 and CYP2C9. The in vivo drug interactions of trime... | ['Anti-Infective Agents', 'Aryl Hydrocarbon Hydroxylases', 'Chromatography, High Pressure Liquid', 'Cytochrome P-450 CYP1A2', 'Cytochrome P-450 CYP2C8', 'Cytochrome P-450 CYP2C9', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Enzyme Inhibitors', 'Female', 'Humans', 'In Vitro Techniques', 'Iso... | 12,019,187 | [['D27.505.954.122'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['E05.196.181.400.300'], ['D08.244.453.005.443', 'D08.244.453.100.750', 'D08.811.682.690.708.170.010.443', 'D08.811.682.690.708.170.020.750', 'D12.776.422.220.453.010.443', 'D12.776.422.220.453.100.750'], ['D08.244.453.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TNF alpha mRNA expression in bronchoalveolar lavage cells from patients with lung fibrosis and TNF alpha activity in the lavage supernatants. | Tumor necrosis factor alpha (TNF alpha) mRNA expression in bronchoalveolar lavage (BAL) cells from patients with lung fibrosis was studied by a reverse transcription-DNA polymerase chain reaction (RT-PCR). The results indicated that two thirds of the tested samples were TNF alpha mRNA positive. On the other hand, TNF a... | ['Base Sequence', 'Bronchoalveolar Lavage Fluid', 'Gene Expression', 'Humans', 'Macrophages', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Pulmonary Fibrosis', 'RNA, Messenger', 'RNA-Directed DNA Polymerase', 'Tumor Necrosis Factor-alpha'] | 7,684,963 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.927.100.500'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['L01.453.245.667'], ['E05.393.620.500'], ['C08.381.765'], ['D13.444.735.544'], ['D08.811.91... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Enhanced expression of matrix metalloproteinase-9 in abdominal aortic aneurysms. | Abdominal aortic aneurysms (AAAs) are characterized by structural alterations of the aortic wall resulting from degradation of collagen and elastin. Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, show strong elastinolytic activity. We examined the levels of mRNA for MMP-2, MMP-9, membrane type (MT)-MMP... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Arterial Occlusive Diseases', 'Female', 'Humans', 'Male', 'Matrix Metalloproteinase 9', 'Middle Aged', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'Tissue Inhibitor of Metalloproteinase-1'] | 11,343,173 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['C14.907.137'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.480.205.360', 'D08.811.277.656.300.480.252.445', 'D08.811.277.656.300.480.525.700.350', 'D08.811.277.656.675.374.205.360', 'D08.811.277.656.675.374.252.445', 'D08... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease. | This study aimed to characterize the incidence, etiology and outcome of infectious episodes in patients with steroid refractory acute GvHD (SR-GvHD). The cohort included 127 adults treated with inolimomab (77%) or etanercept (23%) owing to acute 2-4 SR-GvHD, with a response rate of 43% on day +30 and a 4-year survival ... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Allografts', 'Antibodies, Monoclonal', 'Disease-Free Survival', 'Etanercept', 'Female', 'Follow-Up Studies', 'Graft vs Host Disease', 'Hematologic Neoplasms', 'Humans', 'Infections', 'Male', 'Middle Aged', 'Stem Cell Transplantation', 'Survival Rate'] | 27,595,281 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A01.941.500'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N0... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[A transnasal decompression tube and medicamentous stimulation of intestinal motility in the treatment of diffuse appendicular peritonitis in young children]. | The investigation has shown that best results can be obtained by a combined bilumenal probe for a separate decompression of the stomach and small intestine. Galanthamin gives the best parameters of stimulation of the small intestine peristalsis as compared with Prozerin. | ['Appendicitis', 'Child, Preschool', 'Galantamine', 'Gastrointestinal Motility', 'Humans', 'Infant', 'Intubation, Gastrointestinal', 'Neostigmine', 'Peritonitis'] | 3,787,957 | [['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['M01.060.406.448'], ['D03.132.052.500', 'D03.633.100.079.525'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.585.412', 'E05.497.412'], ['D02.092.877.674.666', 'D02.675.276.602'], ['C01.463.600', 'C06.844.640']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Link protein N-terminal peptide and fullerol promote matrix production and decrease degradation enzymes in rabbit annulus cells. | PURPOSE: Intervertebral disc degeneration is a major cause of back pain. Novel therapies for prevention or reversal of disc degeneration are needed. It is desirable for potential therapies to target both inflammation and matrix degeneration.MATERIALS AND METHODS: The combined regenerative potential of link protein N-te... | ['Animals', 'Annulus Fibrosus', 'Collagenases', 'Cyclooxygenase 2', 'Extracellular Matrix', 'Extracellular Matrix Proteins', 'Fullerenes', 'Interleukin-1alpha', 'Interleukin-6', 'Intervertebral Disc Degeneration', 'Male', 'Peptides', 'Proteoglycans', 'Rabbits'] | 28,509,587 | [['B01.050'], ['A02.165.308.410.250', 'A02.835.232.834.432.250', 'A10.165.382.350.050.250'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D08.811.600.720.750'], ['A11.284.295.310'], ['D12.776.860.300'], ['D01.268.150.250', 'J01.637.512.600.612.350'], ['D12.644.276.374.465.010.300', 'D12.644.276.374... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Results of cisplatin-based polychemotherapy and analysis of prognostic factors in ovarian cancer. Apropos of 106 cases]. | One hundred and six patients with stage Ic to IV ovarian carcinoma were treated by a protocol consisting of optimal debulking surgery followed by 9 cycles of CHAP chemotherapy. Clinical response was confirmed by a second-look procedure. Sixty-nine patients (65%) responded with 54 histological complete remissions (50.8%... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Cisplatin', 'Combined Modality Therapy', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Prognosis'] | 2,635,636 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia. | Various types of atypical antipsychotic drugs (AAPDs) modestly improve the cognitive impairment associated with schizophrenia (CIAS). RP5063 is an AAPD with a diverse and unique pharmacology, including partial agonism at dopamine (DA) D2, D3, D4, serotonin (5-HT)1A, and 5-HT2A receptors (Rs), full agonism at á4â2 nicot... | ['Amphetamine', 'Animals', 'Antipsychotic Agents', 'Central Nervous System Stimulants', 'Cerebral Cortex', 'Conditioning, Operant', 'Disease Models, Animal', 'Dopamine', 'Dose-Response Relationship, Drug', 'Male', 'Memory', 'Mice, Inbred C57BL', 'Motor Activity', 'Neurotransmitter Agents', 'Phencyclidine', 'Psychotic D... | 28,373,127 | [['D02.092.471.683.152.110'], ['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D27.505.696.282', 'D27.505.954.427.220'], ['A08.186.211.200.885.287.500'], ['F02.463.425.179.509'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.092.211.215.406', 'D02.092.311.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PCR methods for identification and specific detection of probiotic lactic acid bacteria. | Probiotics are defined as "microbes improving animal feed." Three lactic acid bacteria, previously selected as probiotic for pig feeding, were identified by sequencing the variable V1 region of the 16S rDNA after PCR amplification primed in the flanking constant region. A VR region showing strong nucleotide differences... | ['Animal Feed', 'Base Sequence', 'DNA Primers', 'DNA, Bacterial', 'DNA, Ribosomal', 'Lactobacillus', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Species Specificity'] | 8,662,180 | [['G07.203.300.300.100', 'J02.500.300.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.212'], ['D13.444.308.475'], ['B03.353.750.450.475', 'B03.510.460.400.410.475.475', 'B03.510.550.450.475'], ['L01.453.245.667'], ['E05.393.620.... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Value of laparoscopic ultrasonography in staging of proximal bile duct tumors. | The additional value of laparoscopic ultrasonography was evaluated prospectively in 35 patients undergoing diagnostic laparoscopy for a suspected potentially resectable proximal bile duct tumor. Findings were compared with transabdominal ultrasonography, laparoscopy, surgery, and pathology. Laparoscopic ultrasonography... | ['Adult', 'Aged', 'Bile Duct Neoplasms', 'Endosonography', 'Gallbladder Neoplasms', 'Humans', 'Laparoscopy', 'Liver Neoplasms', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Staging', 'Peritoneal Neoplasms', 'Prospective Studies'] | 8,979,220 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['E01.370.350.850.280'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'],... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of dietary and hormonal conditions on the activities of glycolytic enzymes in rat epididymal adipose tissue. | 1. Measurements were made of the activities of nine glycolytic enzymes in epididymal adipose tissues obtained from rats that had undergone one of the following treatments: starvation; starvation followed by re-feeding with bread or high-fat diet; feeding with fat without preliminary starvation; alloxan-diabetes; alloxa... | ['Adipose Tissue', 'Animals', 'Diabetes Mellitus, Experimental', 'Diet', 'Dietary Fats', 'Epididymis', 'Fatty Acids', 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'Glycerophosphates', 'Glycolysis', 'Insulin', 'Liver', 'Male', 'Phosphofructokinase-1', 'Pyruvate Kinase', 'Rats', 'Starvation'] | 4,242,855 | [['A10.165.114'], ['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G07.203.650.240'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['A05.360.444.371'], ['D10.251'], ['D08.811.682.657.163.750'], ['D02.033.800.875.750', 'D09.853.875.750', 'D09.894.299', 'D10.570.755.375'], ['G02.111.158.750... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Roles of maize cytochrome P450 (CYP) enzymes in stereo-selective metabolism of hexabromocyclododecanes (HBCDs) as evidenced by in vitro degradation, biological response and in silico studies. | In vitro biotransformation of HBCDs by maize cytochrome P450 (CYP) enzymes, responses of CYPs to HBCDs at protein and transcription levels, and in silico simulation of interactions between CYPs and HBCDs were investigated in order to elucidate the roles of CYPs in the metabolism of HBCDs in maize. The results showed th... | ['Biotransformation', 'Computer Simulation', 'Cytochrome P-450 Enzyme System', 'Environmental Pollutants', 'Hydrocarbons, Brominated', 'Kinetics', 'Molecular Docking Simulation', 'Plant Proteins', 'Zea mays'] | 30,513,427 | [['G03.171', 'G03.787.225', 'G07.690.725.225'], ['L01.224.160'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D27.888.284'], ['D02.455.526.368'], ['G01.374.661', 'G02.111.490'], ['E05.599.595.249', 'L01.224.160.249'], ['D12.776.765'], ['B01.650.940.800.575.912.250.822.966']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Spectroscopic evaluation of the effect of a red microalgal polysaccharide on herpes-infected Vero cells. | The sulfated polysaccharide obtained from a species of red microalga has proved to be a potent antiviral agent against various members of the herpes family. In the present study, we used microscopic Fourier transform infrared spectroscopy (FT-IR) to investigate differences between normal cells, those infected with herp... | ['Animals', 'Antiviral Agents', 'Carbohydrates', 'Chlorocebus aethiops', 'Dose-Response Relationship, Drug', 'Herpesvirus 1, Human', 'Humans', 'Microspectrophotometry', 'Phosphates', 'Polysaccharides', 'Porphyridium', 'Reference Values', 'Spectroscopy, Fourier Transform Infrared', 'Vero Cells'] | 14,658,634 | [['B01.050'], ['D27.505.954.122.388'], ['D09'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G07.690.773.875', 'G07.690.936.500'], ['B04.280.382.100.750.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.712.726.300', 'E05.196.867.826.300'], ['D01.029.260.700.675.374', 'D01.248.497.158.730'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variation in cestode assemblages of Mastomys and Arvicanthis species (rodents: Muridae) from Lake Retba in Western Senegal. | We studied patterns of variation in cestode communities of 3 abundant rodent species that live in sympatry in the Niayes of the Retba Lake, Western Senegal. We evaluated whether the host species have the same parasites and, within host species, whether the variability in parasite community is related to intrinsic (sex,... | ['Animals', 'Binomial Distribution', 'Cestoda', 'Cestode Infections', 'Chi-Square Distribution', 'Ecosystem', 'Female', 'Fresh Water', 'Intestines', 'Male', 'Murinae', 'Prevalence', 'Rodent Diseases', 'Senegal'] | 20,486,740 | [['B01.050'], ['E05.318.740.994.250', 'G17.820.250', 'N05.715.360.750.750.150', 'N06.850.520.830.994.250'], ['B01.050.500.500.736.215'], ['C01.610.335.190'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.280', 'N06.230.232... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys. | We investigated the gastrointestinal transit of liquids, as well as various gastric pH profiles, in fed cynomolgus monkeys. Twelve grams of a biscuit-type solid food were provided 1 h before the test. The acetaminophen method was used to determine the gastric half-emptying time (t(50%)), which provided an estimate of t... | ['Acetaminophen', 'Administration, Oral', 'Animals', 'Food', 'Gastric Acidity Determination', 'Gastric Emptying', 'Gastrointestinal Transit', 'Humans', 'Macaca fascicularis', 'Male', 'Models, Animal', 'Sulfapyridine', 'Sulfasalazine', 'Time Factors'] | 12,698,497 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['E02.319.267.100'], ['B01.050'], ['G07.203.300', 'J02.500'], ['E01.370.225.124.300', 'E01.370.372.300', 'E05.200.124.300'], ['G10.261.360.400'], ['E01.370.372.310', 'G10.261.360.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.40... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Disadvantaged through discrimination? The role of employers in social stratification. | Sociologists have consistently demonstrated that a rather strong association exists between an individual's social class origin and their social class destination, even after controlling for educational attainment. One explanation for this persisting association which is rarely addressed in research in social stratific... | ['Case-Control Studies', 'Educational Status', 'Employment', 'Female', 'Humans', 'Job Application', 'Male', 'Prejudice', 'Sex Factors', 'Social Class', 'United Kingdom'] | 19,941,488 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N01.824.196'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.677.400'], ['F01.145.813.550', 'F01.829.595'], ['N05.715.350.675', 'N06.850.490.875'], ['I01.880.853.996.755', 'N01.824.782'], ['Z01.542.363']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. | BACKGROUND: Opioid receptors are clinically important targets for both pain and alcohol abuse. Three opioid receptors have been cloned: mu, delta, and kappa, all of which effect alcohol consumption in animal models. Naltrexone is a nonselective opioid antagonist used for alcoholism, the clinical utility of which is lim... | ['Alcohol Drinking', 'Animals', 'Behavior, Animal', 'Choice Behavior', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Narcotic Antagonists', 'Protein Multimerization', 'Receptors, Opioid, delta', 'Receptors, Opioid, kappa', 'Receptors, Opioid, mu'] | 19,576,572 | [['F01.145.317.269'], ['B01.050'], ['F01.145.113'], ['F02.463.785.373.346'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.992.635.50... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Body ownership affects visual perception of object size by rescaling the visual representation of external space. | Size perception is most often explained by a combination of cues derived from the visual system. However, this traditional cue approach neglects the role of the observer's body beyond mere visual comparison. In a previous study, we used a full-body illusion to show that objects appear larger and farther away when parti... | ['Adult', 'Cues', 'Female', 'Fixation, Ocular', 'Humans', 'Male', 'Optical Illusions', 'Ownership', 'Personal Space', 'Size Perception'] | 24,806,404 | [['M01.060.116'], ['F02.463.425.234'], ['G14.350.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.446.659'], ['I01.880.604.583.594', 'N04.452.633'], ['F01.145.875.596'], ['F02.463.593.725', 'F02.463.593.778.794']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Combined treatment with cisplatin and radiation therapy for mouse Cl 300 neuroblastoma. | The efficacy of the combined treatment of cisplatin and radiation therapy for mouse C1 300 neuroblastoma was studied. Intraperitoneal cisplatin injections and/or radiation were given from 7 to 21 days after inoculation of the tumor cells into the thigh region of A/Jax mice. The combination of 15 Gy radiation and 6 mg/k... | ['Animals', 'Cell Line', 'Cisplatin', 'Combined Modality Therapy', 'Dose-Response Relationship, Drug', 'Male', 'Mice', 'Mice, Inbred A', 'Neoplasm Transplantation', 'Neuroblastoma', 'Radiotherapy Dosage'] | 4,039,094 | [['B01.050'], ['A11.251.210'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.300', 'B01.050.150.900.649.313.992.635.505.500.400.300'], ['E05.624'], ['C04.557.465.625.600.590.650.550', 'C04.557.47... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Remarkable apoptotic pathway of Hemiscorpius lepturus scorpion venom on CT26 cell line. | OBJECTIVE: Scorpion venom, considered as a treasure trove of various bioactive molecules, is a new approach to induce cancer cell death via apoptosis pathways. In the present study, we evaluated for first time the anti-proliferative efficacy of Hemiscorpius lepturus scorpion venom and its pathway on a colon carcinoma c... | ['Animals', 'Apoptosis', 'Caspase 3', 'Cell Line, Tumor', 'Chlorocebus aethiops', 'Colonic Neoplasms', 'Female', 'Inhibitory Concentration 50', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Proto-Oncogene Proteins c-bcl-2', 'Scorpion Venoms', 'Scorpions', 'Tumor Suppressor Protein p53', 'Vero Cells', 'Xenograft Model Antitum... | 30,617,443 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C04.588.274.476.411.307.180', 'C06.301.371.4... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exogenous niacin treatment increases NADPH oxidase in kiwifruit. | Kiwifruit are a popular fruit worldwide; however, plant growth is threatened by abiotic stresses such as drought and high temperatures. Niacin treatment in plants has been shown to increase NADPH levels, thus enhancing abiotic stresses tolerance. Here, we evaluate the effect of niacin solution spray treatment on NADPH ... | ['Actinidia', 'Free Radicals', 'Fruit', 'NADP', 'NADPH Oxidases', 'Niacin', 'Oxidation-Reduction', 'Plant Leaves'] | 29,412,249 | [['B01.650.940.800.575.912.250.341.500.500'], ['D01.339', 'D02.389'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['D08.811.682.608.575', 'D12.776.331.894', 'D12.776.543.653'], ['D03.066.515.475', 'D03.383.725.547.475']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A Genetic Modifier of the Gut Microbiome Influences the Risk of Graft-versus-Host Disease and Bacteremia After Hematopoietic Stem Cell Transplantation. | The human gut microbiome is involved in vital biological functions, such as maintenance of immune homeostasis and modulation of intestinal development and enhanced metabolic capabilities. Disturbances of the intestinal microbiota have been associated with development and progression of inflammatory conditions, includin... | ['Adolescent', 'Adult', 'Allografts', 'Bacteremia', 'Bacterial Translocation', 'Child', 'Child, Preschool', 'Databases, Factual', 'Female', 'Fucosyltransferases', 'Gastrointestinal Microbiome', 'Genotype', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Infant', 'Male', 'Risk Factors'] | 26,643,031 | [['M01.060.057'], ['M01.060.116'], ['A01.941.500'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['G06.099.114'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['D08.811.913.400.450.300'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.1... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Aging of patients with hepatitis C virus-associated hepatocellular carcinoma: long-term trends in Japan. | The incidence of hepatocellular carcinoma (HCC) in Japan has been increasing. The aim of the present study was to analyze epidemiological changes in Japanese HCC patients. A total of 463 patients with HCC diagnosed at our hospital between 1982 and 2001 were recruited for this study. Cohorts of patients with HCC were ca... | ['Aged', 'Aging', 'Carcinoma, Hepatocellular', 'Cohort Studies', 'Hepacivirus', 'Hepatitis B', 'Hepatitis B virus', 'Hepatitis C', 'Humans', 'Japan', 'Liver Neoplasms', 'Middle Aged', 'Time Factors'] | 16,969,503 | [['M01.060.116.100'], ['G07.345.124'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Navigator-gated coronary magnetic resonance angiography using steady-state-free-precession: comparison to standard T2-prepared gradient-echo and spiral imaging. | RATIONALE AND OBJECTIVES: Recent developments of magnetic resonance imaging enabled free-breathing coronary MRA (cMRA) using steady-state-free-precession (SSFP) for endogenous contrast. The purpose of this study was a systematic comparison of SSFP cMRA with standard T2-prepared gradient-echo and spiral cMRA.METHODS: Na... | ['Animals', 'Coronary Angiography', 'Coronary Disease', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Angiography', 'Swine'] | 12,750,615 | [['B01.050'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250', 'C14.907.585.250'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Routine use of continuous, hyperfractionated, accelerated radiotherapy for non-small-cell lung cancer: a five-center experience. | PURPOSE: To report the results from continuous, hyperfractionated, accelerated radiotherapy (CHART) used as the standard fractionation for radical RT in the management of non-small cell lung cancer (NSCLC) in five United Kingdom centers.METHODS AND MATERIALS: In 2005, the CHART consortium identified six U.K. centers th... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Non-Small-Cell Lung', 'Combined Modality Therapy', 'Dose Fractionation, Radiation', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Radiotherapy Dosage', 'Survival Analysis', 'Survivors'] | 18,355,975 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E02.186'], ['E02.815.639.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.789.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
What the loss of the hormone neuroparsin in the melanogaster subgroup of Drosophila can tell us about its function. | The twelve sequenced Drosophila genomes show the vast majority of neurohormone and neuropeptide genes to be very well conserved. Nonetheless, the gene encoding the hormone neuroparsin has undergone significant evolution. Although Drosophila melanogaster has one of the best known genomes, no neuroparsin gene can be dete... | ['Amino Acid Sequence', 'Animals', 'Computational Biology', 'Drosophila', 'Genes, Insect', 'Insect Hormones', 'Molecular Sequence Data', 'Sequence Alignment', 'Transformation, Genetic'] | 20,226,240 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['H01.158.273.180', 'L01.313.124'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['D06.472.445.573'], ['L01.453.245.667'], ['E05.393.751'], ['G05.728.865']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Reduced aerobic capacity in patients with severe osteoporosis: a cross sectional study. | AIM: It has been previously shown that pulmonary function (PF) is significantly diminished in patients with osteoporosis (OP). But there are few data about the relationship between PF and aerobic capacity of osteoporotic patients and the severity of thoracic kyphosis and time since the diagnosis of OP. The aim of the p... | ['Adult', 'Aged', 'Analysis of Variance', 'Chi-Square Distribution', 'Cross-Sectional Studies', 'Exercise Tolerance', 'Female', 'Humans', 'Kyphosis', 'Male', 'Middle Aged', 'Osteoporosis', 'Respiratory Function Tests', 'Risk Factors', 'Severity of Illness Index'] | 18,418,334 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G11.427.680.270'], ['B01.050.150.900.64... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Longitudinal changes in hearing ability among Swedish conscripts. | An analysis of a military database of about 36,000 tone audiograms from male Swedish conscripts aged 18 to 19 and recorded from 1969 to 1977 demonstrates a successively decreasing prevalence of hearing loss during this period. This might reflect improved therapy during the 1950s and 1960s of ear disorders causing heari... | ['Acoustic Stimulation', 'Adult', 'Amplifiers, Electronic', 'Audiometry', 'Auditory Threshold', 'Environment', 'Hearing Loss, Noise-Induced', 'Humans', 'Longitudinal Studies', 'Male', 'Military Personnel', 'Noise', 'Sweden'] | 8,321,999 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.116'], ['E07.305.061'], ['E01.370.382.375.060'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['G16.500.275', 'N06.230'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['B01.050.150.900.649.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Characterization of intestinal smooth muscle responses and binding sites for endothelin. | The contractile activity of and binding sites for endothelin-1 (ET-1) were investigated in isolated guinea-pig ileal longitudinal smooth muscle (GPILM). ET-1 produced concentration-dependent contractions of GPILM that either slowly subsided in the continued presence of ET-1 or rapidly subsided following washing of the ... | ['Animals', 'Calcium Channels', 'Endothelins', 'Guinea Pigs', 'In Vitro Techniques', 'Intestinal Mucosa', 'Iodine Radioisotopes', 'Male', 'Muscle Contraction', 'Muscle, Smooth', 'Receptors, Cell Surface', 'Receptors, Endothelin'] | 1,318,161 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['A03.556.124.369', 'A10.615.550.444'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['G11.427.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suppression of murine osteoarthritis by 4-methylumbelliferone. | Using in vitro models, we previously reported that 4-methylumbelliferone (4-MU) blocked many of the pro-catabolic features of activated chondrocytes. 4-MU also blocked safranin O loss from human cartilage explants exposed to interleukin 1â (IL1â) in vitro. However, the mechanism for this chondroprotective effect was in... | ['Animals', 'Arthritis, Experimental', 'Drug Evaluation, Preclinical', 'Female', 'Hymecromone', 'Male', 'Mice, Inbred C57BL', 'Osteoarthritis'] | 31,774,188 | [['B01.050'], ['C05.550.114.015', 'E05.598.500.249'], ['E05.290.750', 'E05.337.550'], ['D03.383.663.283.446.912.531', 'D03.633.100.150.446.912.531'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C05.550.114.606', 'C05.799.613']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prostate and colon cancer screening messages in popular magazines. | OBJECTIVES: To 1) compare the number of articles published about prostate, colon, and breast cancer in popular magazines during the past 2 decades, and 2) evaluate the content of in-depth prostate and colon cancer screening articles identified from 1996 to 2001.DESIGN: We used a searchable database to identify the numb... | ['Breast Neoplasms', 'Colonic Neoplasms', 'Decision Making', 'Female', 'Health Education', 'Humans', 'Male', 'Mass Screening', 'Periodicals as Topic', 'Prostatic Neoplasms'] | 15,242,469 | [['C04.588.180', 'C17.800.090.500'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['F02.463.785.373'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Comparative use of biomedical services and traditional healing options by American Indian veterans. | OBJECTIVE: This study described service use among American Indian veterans, compared use patterns across biomedical care and traditional healing options, and tested whether utilization varied as a function of need or availability.METHODS: A cross-sectional survey of 621 male combat veterans selected from tribal rolls w... | ['Adult', 'Community Health Services', 'Cross-Sectional Studies', 'Health Services Accessibility', 'Health Services, Indigenous', 'Hospitals, Veterans', 'Humans', 'Indians, North American', 'Male', 'Medicine, Traditional', 'Middle Aged', 'Midwestern United States', 'Southwestern United States', 'Surveys and Questionnai... | 11,141,531 | [['M01.060.116'], ['N02.421.143'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N04.590.374.350', 'N05.300.430'], ['N02.421.330'], ['N02.278.421.510.180.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.600'], ['E02.190.488', 'I01.076.201.450.654'], ['M01.060.... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Science classroom inquiry (SCI) simulations: a novel method to scaffold science learning. | Science education is progressively more focused on employing inquiry-based learning methods in the classroom and increasing scientific literacy among students. However, due to time and resource constraints, many classroom science activities and laboratory experiments focus on simple inquiry, with a step-by-step approac... | ['Adolescent', 'Computer Simulation', 'Female', 'Humans', 'Internet', 'Male', 'Problem-Based Learning', 'Schools', 'Science', 'Social Perception', 'Students'] | 25,786,245 | [['M01.060.057'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F02.463.425.720', 'I02.158.660', 'I02.903.565'], ['I02.783', 'J03.832'], ['H01.770'], ['F02.463.593.752'], ['M01.848']] | ['Named Groups [M]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
Correlation of retention parameters of pesticides in normal- and reversed-phase systems and their utilization for the separation of a mixture of 14 triazines and urea herbicides by means of two-dimensional thin-layer chromatography. | The selectivities of TLC systems were compared by use of correlations between RF(II) and RF(I) (by analogy with two-dimensional TLC). The greatest spread of points, indicative of individual selectivity, was obtained for nonaqueous mobile phases on silica and aqueous mobile phases on octadecyl silica adsorbent wettable ... | ['Chromatography, Thin Layer', 'Herbicides', 'Pesticides', 'Spectrophotometry, Ultraviolet', 'Triazines'] | 12,184,624 | [['E05.196.181.400.537'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D27.720.031.700', 'D27.888.723'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D03.383.931']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells. | AIM: To explore the role of Med19, a component of the Mediator complex that coactivates DNA-binding transcription factors, in the proliferation and tumorigenesis of human hepatocellular carcinoma cells.METHODS: The human hepatocellular carcinoma cell lines HepG2 and Hep3B were infected with lentiviral vectors encoding ... | ['Animals', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cell Proliferation', 'Genetic Vectors', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Mediator Complex', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'RNA, Small Interfering'] | 21,372,827 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.360.337'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.3... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of a "No Mobile Device" Policy on Developmental Surveillance in a Pediatric Clinic. | Children commonly use mobile devices at pediatric office visits. This practice may affect patient-provider interaction and undermine accuracy of developmental surveillance. A randomized, provider-blinded, controlled trial examined whether a policy prohibiting mobile device use in a pediatric clinic improved accuracy of... | ['Child, Preschool', 'Computers, Handheld', 'Developmental Disabilities', 'Female', 'Humans', 'Infant', 'Male', 'Office Visits', 'Physician-Patient Relations', 'Smartphone', 'Surveys and Questionnaires'] | 29,644,874 | [['M01.060.406.448'], ['L01.224.230.260.550.500'], ['F03.625.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N04.452.758.635'], ['F01.829.401.650.675', 'N05.300.660.625'], ['L01.178.847.698.300.250', 'L01.224.230.260.550.500.750'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.9... | ['Named Groups [M]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Translocations as experiments in the ecological resilience of an asocial mega-herbivore. | Species translocations are remarkable experiments in evolutionary ecology, and increasingly critical to biodiversity conservation. Elaborate socio-ecological hypotheses for translocation success, based on theoretical fitness relationships, are untested and lead to complex uncertainty rather than parsimonious solutions.... | ['Animal Migration', 'Animals', 'Conservation of Natural Resources', 'Ecological and Environmental Phenomena', 'Herbivory', 'Perissodactyla', 'Social Behavior', 'Time Factors'] | 22,295,100 | [['F01.145.113.069.500'], ['B01.050'], ['J01.256', 'N06.230.080'], ['G16.500'], ['F01.145.113.547.600', 'F01.145.407.758', 'G07.203.650.353.758'], ['B01.050.150.900.649.313.984'], ['F01.145.813'], ['G01.910.857']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. | Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is nontoxic to normal cells and preferentially cytotoxic to cancer cells. Recent data suggest that malignant breast cancer cells often become resistant to TRAIL. Pterostilbene (PTER), a naturally occurring analogue of resveratrol found in blueberries, is kn... | ['Apoptosis', 'Apoptosis Regulatory Proteins', 'Cell Line, Tumor', 'Cell Survival', 'Down-Regulation', 'Humans', 'Reactive Oxygen Species', 'Receptors, Death Domain', 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'Signal Transduction', 'Stilbenes', 'TNF-Related Apoptosis-Inducing Ligand', 'Triple Negative Breast ... | 29,164,887 | [['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.339.431', 'D01.650.775'], ['D12.776.543.750.690'], ['D12.776.543.750.690.600', 'D12.776.543.750.705... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endothelium dependent relaxation in rabbit genital resistance arteries is predominantly mediated by endothelial-derived hyperpolarizing factor in females and nitric oxide in males. | PURPOSE: In nongenital arteries a sex difference has been postulated in the dominant endothelium-derived relaxant factor(s), eg nitric oxide, prostacyclin or endothelial-derived hyperpolarizing factor. Knowledge of endothelium-derived relaxant factor mechanisms in genital tissues could influence the development of nove... | ['Animals', 'Biological Factors', 'Endothelium, Vascular', 'Female', 'Male', 'Muscle Relaxation', 'Nitric Oxide', 'Penis', 'Rabbits', 'Sex Characteristics', 'Vagina', 'Vascular Resistance'] | 17,222,682 | [['B01.050'], ['D23'], ['A07.015.700.500', 'A10.272.491.355'], ['G11.427.494.554'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['A05.360.444.492'], ['B01.050.150.900.649.313.968.700'], ['G08.686.815'], ['A05.360.319.779'], ['G09.330.380.921']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative Immunogenicities of full-length Plasmodium falciparum merozoite surface protein 3 and a 24-kilodalton N-terminal fragment. | Recombinant Plasmodium falciparum merozoite surface protein 3 (PfMSP3F) and a 24-kDa fragment from its N terminus (MSP3N) that includes the essential conserved domain, which elicits the maximum antibody (Ab)-dependent cellular inhibition (ADCI), were expressed as soluble proteins in Escherichia coli. Both proteins were... | ['Adjuvants, Immunologic', 'Aluminum Hydroxide', 'Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Escherichia coli', 'Freeze Drying', 'Gene Expression', 'Humans', 'Immunoglobulin G', 'Malaria Vaccines', 'Male', 'Mannitol', 'Mice', 'Mice, Inbred BALB C', 'Monocytes', 'Oleic Acids', 'Parasitemia', 'Plasmodium ... | 21,632,889 | [['D27.505.696.477.067'], ['D01.045.250.050', 'D01.056.037', 'D01.248.497.158.459.075'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of visual and tactile feedback on kinematic synergies in the grasping hand. | The human hand uses a combination of feedforward and feedback mechanisms to accomplish high degree of freedom in grasp control efficiently. In this study, we used a synergy-based control model to determine the effect of sensory feedback on kinematic synergies in the grasping hand. Ten subjects performed two types of gr... | ['Biomechanical Phenomena', 'Computer Simulation', 'Feedback, Sensory', 'Fingers', 'Hand', 'Hand Strength', 'Humans', 'Nontherapeutic Human Experimentation', 'Principal Component Analysis', 'Touch'] | 26,660,896 | [['G01.154.090', 'G01.374.089'], ['L01.224.160'], ['F04.754.137.301.500', 'F04.754.308.500.500', 'F04.754.339', 'G07.410.732.500'], ['A01.378.800.667.430'], ['A01.378.800.667'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.445.750', 'H01.770.644.145.365.750'], ['E05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Clinical case of the month. Antibiotics and hemodialysis: three cases of neurotoxicity from Maxipime]. | The metabolism of drugs is altered in dialysed patients. We report three clinical cases of neurological toxicity from cefepime in dialysed patient. This molecule can induce in renal insufficiency patients various reversible neurological manifestations like metabolic encephalopathy, myoclonies, or a state of status epil... | ['Aged', 'Anti-Bacterial Agents', 'Brain Diseases', 'Cefepime', 'Cephalosporins', 'Female', 'Humans', 'Male', 'Middle Aged', 'Renal Dialysis'] | 18,561,766 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['C10.228.140'], ['D02.065.589.099.249.173', 'D02.886.665.074.173', 'D03.633.100.300.249.173'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.870.300', 'E02.912.800']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protective monoclonal antibodies from mice vaccinated or chronically infected with Schistosoma mansoni that recognize the same antigens. | An IgM monoclonal antibody, designated mAb 1.G1, has been generated from spleen cells of mice immunized with irradiated Schistosoma mansoni cercariae. As determined by indirect immunofluorescence, mAb 1.G1 binds to the surface membrane of schistosomula and to the ciliated plates of miracidia. mAb 1.G1 also binds to the... | ['Animals', 'Antibodies, Helminth', 'Antibodies, Monoclonal', 'Antigens, Helminth', 'Chronic Disease', 'Epitopes', 'Fluorescent Antibody Technique', 'Immunization, Passive', 'Immunoglobulin M', 'Mice', 'Mice, Inbred BALB C', 'Schistosoma mansoni', 'Schistosomiasis mansoni', 'Vaccination'] | 2,445,819 | [['B01.050'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.223'], ['C23.550.291.500'], ['D23.050.550'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. | Chromosomal aberrations (CAs) are important genetic alterations in the development and progression of the majority of human cancers. The frequency with which such alterations occur depends to a large extent on polymorphisms of DNA-repair genes and in genes coding for xenobiotic metabolizing enzymes, which are involved ... | ['Bleomycin', 'Chromosome Aberrations', 'DNA Repair', 'Female', 'Humans', 'Linkage Disequilibrium', 'Male', 'Polymorphism, Genetic'] | 17,685,459 | [['D09.400.420.110', 'D12.644.233.110'], ['C23.550.210', 'G05.365.590.175'], ['G02.111.222', 'G05.219'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.348.500'], ['G05.365.795']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance. | The role of heart-type fatty acid-binding protein (FABP3) in human physiology as an intracellular carrier of fatty acids (FAs) has been well-documented. In this study, we aimed to develop an analytical method to study real-time interaction kinetics between FABP3 immobilized on the sensor surface and unsaturated C18 FAs... | ['Fatty Acid Binding Protein 3', 'Fatty Acid-Binding Proteins', 'Fatty Acids, Unsaturated', 'Humans', 'Kinetics', 'Liposomes', 'Surface Plasmon Resonance'] | 24,581,547 | [['D12.776.157.170.125'], ['D12.776.157.170'], ['D10.251.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['E05.196.890', 'E05.601.043.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Experience with trepanotrabeculectomy. | The authors analysed the effect of 100 trepanotrabeculectomy operations performed in primary (79 cases), in congenital (16 cases) and in secondary (5 cases) types of glaucoma. The operation itself could normalize the intraocular pressure in 87% of the cases, in 8% the intraocular pressure was normalized by miotics afte... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Glaucoma', 'Humans', 'Infant', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Optic Disk', 'Postoperative Complications', 'Trabecular Meshwork', 'Visual Acuity'] | 580,334 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G14.440'], ['M01.060.116.630'], ['A08.800.800.120.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term follow-up of pulmonary function in Fabry disease: A bi-center observational study. | INTRODUCTION: Fabry disease (FD) is a lysosomal storage disorder leading to decreased á-galactosidase A enzyme activity and subsequent abnormal accumulation of glycosphingolipids in various organs. Although histological evidence of lung involvement has been demonstrated, the functional impact of these changes is less c... | ['Adult', 'Airway Obstruction', 'Fabry Disease', 'Female', 'Humans', 'Linear Models', 'Lung', 'Male', 'Middle Aged', 'Respiratory Function Tests', 'Risk Factors', 'Sex Factors', 'Smoking', 'Young Adult'] | 28,742,806 | [['M01.060.116'], ['C08.618.846.185'], ['C10.228.140.163.100.435.825.200', 'C10.228.140.300.275.374', 'C14.907.253.329.374', 'C16.320.322.124', 'C16.320.565.189.435.825.200', 'C16.320.565.398.641.803.300', 'C16.320.565.595.554.825.200', 'C18.452.132.100.435.825.200', 'C18.452.584.687.803.300', 'C18.452.648.189.435.825.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk. | The identification of low-penetrance genes, the polymorphisms of which increase an individual's risk of developing cancer, are likely to be extremely important in the general population. In this report we analyzed two genes involved in detoxification. In a number of loci, we identified polymorphic variation correlating... | ['Arylamine N-Acetyltransferase', 'Base Sequence', 'Cohort Studies', 'Colonic Neoplasms', 'Cytochrome P-450 CYP2D6', 'Cytochrome P-450 Enzyme System', 'DNA Primers', 'Female', 'Gene Expression Regulation, Enzymologic', 'Humans', 'Male', 'Mixed Function Oxygenases', 'Molecular Sequence Data', 'Outpatients', 'Polymerase ... | 7,497,646 | [['D08.811.913.050.134.138'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D08.244.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Sensory migraine aura is not associated with structural grey matter abnormalities. | Migraine with aura (MA) is characterized by cortical dysfunction. Frequent aura attacks may alter cerebral cortical structure in patients, or structural grey matter abnormalities may predispose MA patients to aura attacks. In the present study we aimed to investigate cerebral grey matter structure in a large group of M... | ['Adolescent', 'Adult', 'Brain Mapping', 'Cerebral Cortex', 'Female', 'Gray Matter', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Migraine with Aura', 'Young Adult'] | 27,298,761 | [['M01.060.057'], ['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.228.140.546.399.750... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Novel method for safe cauterisation of posterior epistaxis. | INTRODUCTION: In epistaxis, anterior bleeding points are easily cauterised under direct vision, but those which occur in the posterior nose present a greater challenge. Standard cautery techniques limit simultaneous use of other equipment in the narrow posterior nose.METHODS: This article presents a novel device which ... | ['Cautery', 'Epistaxis', 'Equipment Design', 'Humans', 'Nose', 'Nose Diseases', 'Suction', 'Treatment Outcome'] | 19,216,836 | [['E02.154', 'E04.014.170'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.040'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['C08.460', 'C09.603'], ['E04.237.890'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A common variant near the PRL gene is associated with increased adiposity in males. | A common variant (rs4712652) adjacent to the prolactin gene was recently associated with obesity using a genome-wide association study. The aim of this study was to replicate the association between rs4712652 and obesity and further examine if rs4712652 is associated with fat percentage and adiponectin levels in a popu... | ['Adiponectin', 'Adipose Tissue', 'Adiposity', 'Body Mass Index', 'DNA, Intergenic', 'Female', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Polymorphism, Single Nucleotide', 'Prolactin'] | 20,846,890 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['A10.165.114'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Logistic regression against a divergent Bayesian network]. | This article is a discussion about two statistical tools used for prediction and causality assessment: logistic regression and Bayesian networks. Using data of a simulated example from a study assessing factors that might predict pulmonary emphysema (where fingertip pigmentation and smoking are considered); we posed th... | ['Bayes Theorem', 'Causality', 'Confounding Factors, Epidemiologic', 'Data Interpretation, Statistical', 'Decision Making', 'Humans', 'Logistic Models', 'Pulmonary Embolism', 'Skin Pigmentation', 'Smoking'] | 25,658,774 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['N05.715.350.200', 'N06.850.490.625'], ['N05.715.350.240', 'N06.850.490.718'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Effects of voluntary exercise on hippocampal long-term potentiation in morphine-dependent rats. | This study was designed to examine the effect of voluntary exercise on hippocampal long-term potentiation (LTP) in morphine-dependent rats. The rats were randomly distributed into the saline-sedentary (Sal/Sed), the dependent-sedentary, the saline-exercise (Sal/Exc), and the dependent-exercise (D/Exc) groups. The Sal/E... | ['Analysis of Variance', 'Animals', 'Disease Models, Animal', 'Electric Stimulation', 'Excitatory Postsynaptic Potentials', 'Hippocampus', 'Long-Term Potentiation', 'Male', 'Morphine Dependence', 'Physical Conditioning, Animal', 'Rats', 'Rats, Wistar', 'Time Factors'] | 24,141,180 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.723.402'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spinal 2-chloroprocaine: a comparison with procaine in volunteers. | Recent studies using preservative-free 2-chloroprocaine (2-CP) for spinal anesthesia have shown it to be a reliable short-acting drug that provides similar anesthesia to lidocaine. In this randomized, double-blind, crossover study, we compared the characteristics of spinal 2-CP (30 mg) with those of procaine (80 mg) in... | ['Adult', 'Anesthesia, Spinal', 'Anesthetics, Local', 'Blood Pressure', 'Cross-Over Studies', 'Double-Blind Method', 'Electric Stimulation', 'Electrocardiography', 'Female', 'Humans', 'Isometric Contraction', 'Male', 'Muscle Contraction', 'Muscle, Skeletal', 'Oximetry', 'Pain Measurement', 'Procaine', 'Prospective Stud... | 15,673,896 | [['M01.060.116'], ['E03.155.086.331'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regional-scale directional changes in abundance of tree species along a temperature gradient in Japan. | Climate changes are assumed to shift the ranges of tree species and forest biomes. Such range shifts result from changes in abundances of tree species or functional types. Owing to global warming, the abundance of a tree species or functional type is expected to increase near the colder edge of its range and decrease n... | ['Biodiversity', 'Forests', 'Global Warming', 'Japan', 'Population Dynamics', 'Temperature', 'Trees'] | 25,712,048 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G16.500.275.157.437', 'N06.230.124.343'], ['G16.500.175.374.500'], ['Z01.252.474.463', 'Z01.639.595'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The radioactivity content of United Kingdom coal. | Twenty samples of coal representing each of the seven major regions of the National Coal Board have been analysed for their natural radioactivity content. A variety of methods have been used to verify the results, but the major technique used was radiation spectrometry of 3 kg samples. The results indicate a mean value... | ['Coal', 'Potassium Radioisotopes', 'Radium', 'Spectrometry, Gamma', 'Thorium', 'United Kingdom', 'Uranium'] | 6,729,445 | [['D20.345.108', 'N06.230.132.258.108'], ['D01.268.549.550.500.700', 'D01.268.557.575.500.700', 'D01.496.705.700', 'D01.496.749.690', 'D01.552.528.652.500.700', 'D01.552.547.650.500.700'], ['D01.268.271.770', 'D01.268.552.775', 'D01.268.556.775', 'D01.496.749.305.770', 'D01.552.539.745', 'D01.552.544.775'], ['E05.196.8... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The tree BVOC index. | Urban trees can produce a number of benefits, among them improved air quality. Biogenic volatile organic compounds (BVOCs) emitted by some species are ozone precursors. Modifying future tree planting to favor lower-emitting species can reduce these emissions and aid air management districts in meeting federally mandate... | ['Air Pollutants', 'Air Pollution', 'Biological Products', 'Cities', 'Forestry', 'Government Programs', 'Trees', 'Volatile Organic Compounds'] | 21,435,760 | [['D27.888.284.101'], ['N06.850.460.100'], ['D20.215'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['J01.576.430'], ['I01.451'], ['B01.650.915'], ['D02.974']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
A microbiological study of neonatal conjunctivae and conjunctivitis. | To investigate the importance of chlamydiae, ureaplasmas, Mycoplasma hominis, and anaerobic bacteria in the pathogenesis of neonatal conjunctivitis in the Harrow population conjunctival specimens from 104 infants with conjunctivitis and 104 similar healthy neonates were examined. The incidence of neonatal conjunctiviti... | ['Conjunctiva', 'Conjunctivitis', 'Escherichia coli', 'Humans', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Staphylococcus aureus', 'Streptococcus'] | 336,080 | [['A09.371.060.200', 'A09.371.337.168'], ['C11.187.183'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C16.614'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100'], ['B03.353... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transient meiotic arrest maintained by DON (6-diazo-5-oxo-l-norleucine) enhances nuclear/cytoplasmic maturation of porcine oocytes. | The developmental competence of in vitro-matured oocytes is still lower than that of the in vivo-matured oocytes due to precocious meiotic resumption and inappropriate cytoplasmic maturation. Although numerous efforts have been attempted to accomplish better in vitro maturation (IVM) condition, only limited progress ha... | ['Animals', 'Antibiotics, Antineoplastic', 'Cell Nucleus', 'Cytoplasm', 'Diazooxonorleucine', 'Embryonic Development', 'Female', 'Fertilization in Vitro', 'In Vitro Oocyte Maturation Techniques', 'Meiosis', 'Nuclear Transfer Techniques', 'Oocytes', 'Pregnancy', 'Swine'] | 31,652,418 | [['B01.050'], ['D27.505.954.248.106'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['D02.172.508', 'D12.125.213.568.175'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['E02.875.800.750', 'E05.820.800.750'], ['E02.875.800.906', 'E05.820.800.906'], ['G04.144.220.220.687', 'G05.113.220.687... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples. | BACKGROUND: Ferroportin is a transmembrane protein responsible for iron export from enterocytes and macrophages. Mutation c.744G ? T (Q248H), located in exon 6 of the ferroportin gene SLC40A1, is found as a polymorphism in populations of African origin. This mutation has been extensively analysed in African-Americans, ... | ['Africa South of the Sahara', 'African Continental Ancestry Group', 'Amino Acid Substitution', 'Cation Transport Proteins', 'Chromosomes, Human', 'Gene Frequency', 'Haplotypes', 'Humans', 'Mutation'] | 21,231,898 | [['Z01.058.290'], ['M01.686.508.100'], ['E05.393.420.601.035', 'G05.558.109'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['G05.330'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590']] | ['Geographicals [Z]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat. | The antihypertensive mechanism of alpha2-adrenoceptor agonists, such as clonidine and rilmenidine, is not completely elucidated, although it is probably due to reduction of sympathetic tone mediated by stimulation of central alpha2-adrenoceptors. Because activation of alpha2-adrenoceptors on endothelial cells induces r... | ['Anesthesia', 'Animals', 'Antihypertensive Agents', 'Blood Pressure', 'Clonidine', 'Cyclic GMP', 'Drug Interactions', 'Enzyme Inhibitors', 'Hypotension', 'Male', 'Methylene Blue', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Oxazoles', 'Rats', 'Rats, Wistar', 'Rilmenidine'] | 10,813,383 | [['E03.155'], ['B01.050'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.383.129.308.436.500'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['G07.690.773.968'], ['D27.505.519.389'], ['C14.907.514'], ['D02.886.369.517', 'D03.633.300.783.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Semiquantitative immunocytochemical analysis of GABAA receptor subunit expression in the rat neostriatum. | A semiquantitative immunogold technique was used to investigate the levels of expression of specific GABAA receptor subunits in different regions (dorsolateral, dorsomedial and ventromedial regions) of the rat striatum. The results indicate that the subunits studied can be classified into three groups on the basis of t... | ['Animals', 'Immunohistochemistry', 'Neostriatum', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, GABA-A'] | 8,865,360 | [['B01.050'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['A08.186.211.200.885.287.249.487.550'], ['B01.050.150.900.649.313.992... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioactivity of instant glucose. Failure of absorption through oral mucosa. | The efficacy of instant glucose as a potential treatment for hypoglycemia was studied in normal volunteers, with therapeutic doses administered in the buccal cavity. 2-Tritiated glucose (50 mu Ci) was homogenized into each dose before use. Mean blood glucose and serum insulin concentrations were unaltered by instant gl... | ['Adult', 'Blood Glucose', 'Consciousness', 'Deglutition', 'Drug Evaluation', 'Gagging', 'Glucose', 'Humans', 'Hypoglycemia', 'Informed Consent', 'Insulin', 'Insulin Coma', 'Intestinal Absorption', 'Mouth Mucosa'] | 691,147 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['F02.463.188.409', 'F02.830.233'], ['G10.261.178'], ['E05.290.625', 'E05.337.425'], ['C23.888.821.414', 'F02.830.702.157', 'G10.261.338', 'G11.561.731.251'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['I01.880.604.473.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A potent and long-acting NK-1 selective agonist. | In rats anesthetized with urethane, substance P exerts a short-lasting hypotensive effect and stimulates salivary secretion. These effects are significantly increased and prolonged by 5 to 10 times, when substance P is administered in the presence of a mixture of peptidase inhibitors (captopril, thiorphan and phosphora... | ['Animals', 'Blood Pressure', 'Dose-Response Relationship, Drug', 'Peptide Fragments', 'Protease Inhibitors', 'Rats', 'Rats, Wistar', 'Receptors, Neurotransmitter', 'Receptors, Tachykinin', 'Salivation', 'Substance P', 'Time Factors'] | 7,680,743 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.541'], ['D27.505.519.389.745'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.543.750.720'], ['D12.776.543.750.695.862', 'D12.776.543.750.720.600.830', 'D... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An isotope effect on the comparative quantification of flavonoids by means of methylation-based stable isotope dilution coupled with capillary liquid chromatography/mass spectrometry. | Ionization suppression is a serious problem in liquid chromatography/mass spectrometry-based metabolomics, and stable isotope dilution-based comparative quantification is one of the most important methods of overcoming this problem. Herein, the use of [(13)C]-methylation-based stable isotope dilution for comparative qu... | ['Artifacts', 'Carbon Isotopes', 'Chromatography, Liquid', 'Flavonoids', 'Mass Spectrometry', 'Methylation'] | 16,233,758 | [['E05.047'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.181.400'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['E05.196.566'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early experience of laparoscopic complete en bloc excision for choledochal cysts in adults. | BACKGROUND: For choledochal cyst, the treatment of choice is total excision of the cyst because there is a risk of biliary cancer including the gallbladder. The current report describes the authors' early experiences using their technique of laparoscopic en bloc excision of choledochal cysts with Roux-en-Y biliary reco... | ['Adolescent', 'Adult', 'Aged', 'Choledochal Cyst', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Retrospective Studies', 'Young Adult'] | 22,549,376 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C04.182.198', 'C06.130.120.127', 'C06.198.184', 'C16.131.314.184'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. | The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neurons to classify them in an unbiased manner, independent of any a priori knowledge of sensory subtypes. Our results reveal... | ['Animals', 'Behavior, Animal', 'Cell Size', 'Female', 'Gene Expression', 'Inflammation', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Pruritus', 'Sensory Receptor Cells', 'Sequence Analysis, RNA'] | 25,420,068 | [['B01.050'], ['F01.145.113'], ['G04.325'], ['G05.297'], ['C23.550.470'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C17.800.685', 'C23.888.885.625'], ['A08.675.650.915', 'A08.800.950', 'A11.671.650.915'], ['E05.393.760.710']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low expression of basic fibroblastic growth factor in mesenchymal stem cells and bone marrow of children with aplastic anemia. | BACKGROUND: Our previous experiments with gene chip suggested that basic fibroblastic growth factor (FGF2) levels were lower in mesenchymal stem cell (MSC) from aplastic anemia patients. The purpose of this study was to determine the expression of FGF2 in MSC and in bone marrow of children with aplastic anemia to bette... | ['Adipocytes', 'Anemia, Aplastic', 'Bone Marrow Cells', 'Cell Differentiation', 'Cells, Cultured', 'Child', 'Colony-Forming Units Assay', 'Down-Regulation', 'Extracellular Fluid', 'Female', 'Fibroblast Growth Factor 2', 'Gene Expression Regulation', 'Humans', 'Leukocytes, Mononuclear', 'Male', 'Mesenchymal Stem Cells',... | 24,308,692 | [['A11.329.114'], ['C15.378.071.085', 'C15.378.190.223.250'], ['A11.148', 'A15.378.316'], ['G04.152'], ['A11.251'], ['M01.060.406'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.284.295.260', 'A12.207.270'], ['D12.644.276.624.120', 'D12.776.467.624.... | ['Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Rheumatologist-patient communication about exercise and physical therapy in the management of rheumatoid arthritis. | OBJECTIVE: Little is known about the features and role of exercise discussions between rheumatologists and patients. The goals of this study were to: 1) describe rheumatologists' and patients' attitudes and beliefs regarding exercise and physical therapy for rheumatoid arthritis (RA); 2) describe frequency and length o... | ['Arthritis, Rheumatoid', 'Attitude of Health Personnel', 'Attitude to Health', 'Communication', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Physical Therapy Modalities', 'Physician-Patient Relations', 'Prospective Studies... | 10,513,508 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['F01.100.050', 'N05.300.100'], ['F01.100.150', 'N05.300.150'], ['F01.145.209', 'L01.143'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Technology, Ind... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort. | OBJECTIVE: Neuroleptics and neuroleptic-like drugs are known to induce parkinsonism, which may reveal underlying Parkinson disease (PD) in some cases. We assessed the long-term risk of developing PD after past exposure to these drugs, in a 15-year prospective population-based elderly cohort study.METHODS: We used the C... | ['Aged', 'Aged, 80 and over', 'Antipsychotic Agents', 'Cohort Studies', 'Female', 'France', 'Humans', 'Incidence', 'Male', 'Parkinson Disease', 'Prevalence', 'Prospective Studies', 'Risk'] | 23,019,267 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The phakomatoses as paracrine growth disorders (paracinopathies). | A microcomputer database management system retrieved all 170 probands with phakomatoses evaluated through the genetic clinics at the University of South Florida between January 2, 1982 and December 31, 1987. Neurofibromatosis (NF) was the diagnosis of 118 of them; 42 had other phakomatoses and 10 had transitional pheno... | ['Dysplastic Nevus Syndrome', 'Growth Substances', 'Hamartoma', 'Humans', 'Melanosis', 'Mutation', 'Neoplastic Syndromes, Hereditary', 'Neurofibromatosis 1', 'Skin Neoplasms', 'Syndrome', 'Tuberous Sclerosis'] | 2,107,047 | [['C04.557.665.560.260', 'C04.700.305', 'C16.320.700.305'], ['D27.505.696.377'], ['C04.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.621.430.530'], ['G05.365.590'], ['C04.700', 'C16.320.700'], ['C04.557.580.600.580.590.650', 'C04.700.631.650', 'C10.562.600.500', 'C10.574.500.549.400', 'C10.668.829.6... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-assembly of DNA-coded nanoclusters. | We present a theoretical discussion of a self-assembly scheme which makes it possible to use DNA to uniquely encode the composition and structure of microparticle and nanoparticle clusters. These anisotropic DNA-decorated clusters can be further used as building blocks for hierarchical self-assembly of larger structure... | ['Colloids', 'Computer Simulation', 'Crystallization', 'DNA', 'Models, Chemical', 'Models, Molecular', 'Nanostructures', 'Nucleic Acid Conformation'] | 17,155,011 | [['D20.280', 'D26.255.165'], ['L01.224.160'], ['E05.196.300', 'G02.171'], ['D13.444.308'], ['E05.599.495'], ['E05.599.595'], ['J01.637.512'], ['G02.111.570.820.486', 'G05.360.580']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Food allergens and respiratory symptoms. | Food allergy may be clinically expressed by a variety of respiratory symptoms, which can be provoked either by IgE- or cellular mediated reactions. Among the diagnostic procedures, newly introduced atopy patch test seems to be important for diagnosis of cellular, delayed immune reactions. We studied the prevalence of p... | ['Allergens', 'Antigens, Dermatophagoides', 'Child', 'Egg Hypersensitivity', 'Female', 'Food Hypersensitivity', 'Humans', 'Hypersensitivity, Immediate', 'Immunoglobulin E', 'Immunoglobulin G', 'Lycopersicon esculentum', 'Male', 'Milk Hypersensitivity', 'Poaceae', 'Respiratory Tract Diseases', 'Skin Tests', 'Surveys and... | 19,218,655 | [['D23.050.063'], ['D23.050.181'], ['M01.060.406'], ['C20.543.480.370.150'], ['C20.543.480.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.480'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of nifedipine on the adrenocortical and somatotrophic secretory reserve and TSH and thyroid hormone plasma levels. | The authors investigated the effect of one week's administration of therapeutic doses of the calcium antagonist nifedipine on the hormone homeostasis of clinically healthy subjects. The insignificant tendency towards an increase of the adrenocorticotrophic and somatotrophic secretory reserve and the unaltered levels of... | ['Adrenal Cortex Hormones', 'Adult', 'Female', 'Growth Hormone', 'Humans', 'Hydrocortisone', 'Nifedipine', 'Thyroid Hormones', 'Thyrotropin', 'Thyroxine', 'Triiodothyronine', 'Verapamil'] | 6,684,587 | [['D06.472.040'], ['M01.060.116'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['D03.383.725.203.540'], ['D06.472.931'], ['D06.472.699.631.525.883', 'D12.644.548.691.525.88... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alternating versus synchronous ventilation of left and right lungs in piglets. | OBJECTIVE: We tested whether alternating ventilation (AV) of each lung (i.e. with a phase difference of half a ventilatory cycle) would decrease central venous pressure and so increase cardiac output when compared with simultaneous ventilation (SV) of both lungs.THEORY: If, during AV, the inflated lung expands partly v... | ['Animals', 'Cardiac Output', 'Central Venous Pressure', 'Hemodynamics', 'Respiration, Artificial', 'Respiratory Mechanics', 'Swine'] | 8,750,126 | [['B01.050'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G09.330.380.076.732.336'], ['G09.330.380'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['G09.772.705.700'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a. | The 3'-epi diastereomer of K-252a was synthesized with the goal of evaluating the stereochemical requirements of the 3'-sugar alcohol on kinase inhibitory activity. Inverting the 3'-alcohol resulted in a 20 nM inhibitor of VEGFR2 and a 1 nM inhibitor of TrkA tyrosine kinase. | ['Alcohols', 'Carbazoles', 'Chromatography, High Pressure Liquid', 'Enzyme Inhibitors', 'Indole Alkaloids', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Phosphotransferases', 'Receptor, trkA', 'Stereoisomerism', 'Vascular Endothelial Growth Factor Receptor-2'] | 12,270,156 | [['D02.033'], ['D03.633.100.473.144', 'D03.633.300.148'], ['E05.196.181.400.300'], ['D27.505.519.389'], ['D03.132.436', 'D03.633.100.473.402', 'D03.633.100.496.500.500'], ['E05.196.867.519'], ['E05.599.595'], ['D08.811.913.696'], ['D08.811.913.696.620.682.725.400.660', 'D12.776.543.750.630.496', 'D12.776.543.750.750.40... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Time trends in incidence and prognosis of primary liver cancer and liver metastases of unknown origin in a Danish region, 1985-2004. | OBJECTIVES: Changes, over the last 20 years, in the diagnostic procedures and treatment of primary liver cancer (PLC) and liver metastases of unknown origin (LMUO) may have affected the clinical course of both cancers. Few longitudinal studies examined this issue. In a population-based setting, we studied changes in th... | ['Adolescent', 'Adult', 'Aged', 'Denmark', 'Female', 'Humans', 'Incidence', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoplasms, Unknown Primary', 'Prognosis', 'Survival Analysis'] | 18,188,029 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.542.816.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['C04.69... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
"Witch doctor?" A hexing case of dermatitis. | A Mexican-American woman presented with exfoliative dermatitis complicated by a "curse". She was cured by a combination of bland topical therapy and casting off of the spell by a curandero. | ['Adult', 'Dermatitis, Exfoliative', 'Ethnic Groups', 'Female', 'Humans', 'Magic', 'Mexico', 'Psychophysiologic Disorders', 'United States'] | 138,572 | [['M01.060.116'], ['C17.800.174.318', 'C17.800.815.318'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.901.411', 'I01.076.201.450.897.439'], ['Z01.107.567.589'], ['C23.888.592.700'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Cutaneous ureterostomy in children--long-term followup. | From 1963 to 1983, 45 children with benign disease underwent urinary diversion with cutaneous ureterostomy. Patient selection for cutaneous ureterostomy was predicted on the presence of at least 1 dilated ureter. Followup ranged from 4 months to 20 years, with a mean of 7.9 years. Of the patients 29 (64 per cent) had a... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Ileum', 'Infant', 'Male', 'Postoperative Complications', 'Time Factors', 'Ureteral Obstruction', 'Urinary Bladder, Neurogenic', 'Urinary Diversion'] | 4,032,552 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['M01.060.703'], ['C23.550.767'], ['G01.910.857'], ['C12.777.725.776', 'C13.351.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Simplification in locating and dissecting the levator muscle of the upper eyelid in surgery for ptosis]. | BACKGROUND: While repairing eyelid ptosis by aponeurotic resection by anterior approach, the risk of damaging the levator complex and the conjunctiva is significant. In order to simplify the dissection between M?ller's muscle and the underneath conjunctiva, we use a modification of the usual surgical technique.METHODS:... | ['Blepharoptosis', 'Eyelids', 'Humans', 'Methods'] | 9,499,982 | [['C11.338.204'], ['A01.456.505.420.504', 'A09.371.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of the required surface area of a final clarifier for an activated-sludge system. | A generic methodology for determining the required surface area of a final clarifier is presented. Clarification and thickening requirements are integrated to form a unified procedure for final clarifier design. The new method is based on results obtained by Yuen (2002) on the solids flux theory for a secondary clarifi... | ['Filtration', 'Models, Theoretical', 'Sewage', 'Waste Disposal, Fluid', 'Water Movements'] | 15,168,850 | [['E05.196.454', 'G01.280', 'G02.263'], ['E05.599'], ['D20.944.932.500'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['G16.500.971', 'N06.230.132.644.750', 'N06.230.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain. | Blockage along with sudden restoration of blood following ischemia, results in several cascading events, such as a massive ROS production which plays an important role in the pathophysiology of ischemia. NADPH oxidase complex in mitochondria complex is believed to be the major source for ROS production. The present stu... | ['Acetophenones', 'Animals', 'Brain Ischemia', 'Enzyme Inhibitors', 'Hippocampus', 'Male', 'Maze Learning', 'NADPH Oxidases', 'Oxidative Stress', 'Rats', 'Rats, Wistar', 'Reperfusion Injury', 'Treatment Outcome'] | 29,091,896 | [['D02.522.120'], ['B01.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['D27.505.519.389'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['F02.463.425.874.500'], ['D08.811.682.608.575', 'D12.776.331.894', 'D12.776.543.653'], ['G03.673', 'G07.775.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot study. | OBJECTIVE: To compare joint and soft tissue aspiration using a conventional technique with an ultrasound (US) guided technique.METHODS: In the conventional group, 32 joints in 30 consecutive patients referred for joint aspiration and injection to an experienced consultant rheumatologist were aspirated. In the US guided... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthritis', 'Biopsy, Needle', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Rheumatology', 'Synovial Fluid', 'Ultrasonography, Interventional'] | 12,375,335 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.550.114'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of earphone radiation recorded from hearing impaired subjects and a resistor network simulator. | Electromagnetic radiation emitted by earphones is a potential source of contamination of auditory evoked potentials, particularly when long-duration stimuli are used to evoke the response. One practical solution to this problem would be to estimate the magnitude and characteristics of this earphone radiation so that an... | ['Cochlea', 'Electric Stimulation', 'Electrodes', 'Electromagnetic Fields', 'Evoked Potentials, Auditory', 'Female', 'Hearing', 'Hearing Aids', 'Hearing Loss, Bilateral', 'Humans', 'Male', 'Phonetics', 'Radiation'] | 7,841,899 | [['A09.246.300.246'], ['E05.723.402'], ['E07.305.250'], ['G01.358.500.260', 'G01.358.750.500'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['E07.305.906.500', 'E07.814.458'], ['C09.218.458.341.374', 'C10.597.751.418.341.374', 'C23.888.592.763.39... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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