Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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[Man and the diversity of his genome. An extraordinary phase in the history of population genetics]. | Population genetics is almost eighty years old, but benefited only very recently from the advantages of direct DNA analysis. Nevertheless, much knowledge had already accumulated and was completely confirmed by the study of DNA markers. Major benefits of the latter came with microsatellites. It allowed to discover an er... | ['Africa', 'Europe', 'Genetic Variation', 'Genetics, Population', 'Genome, Human', 'History, 20th Century', 'Humans'] | 9,769,919 | [['Z01.058'], ['Z01.542'], ['G05.365'], ['H01.158.273.343.335'], ['G05.360.340.350'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Coffee has hepatoprotective benefits in Brazilian patients with chronic hepatitis C even in lower daily consumption than in American and European populations. | The potential role of coffee as a hepatoprotective substance for chronic liver diseases has been widely discussed. Our main aim was to evaluate the effect of coffee intake regarding clinical, biochemical tests and liver biopsy data in treatment na?ve patients with chronic hepatitis C. One hundred and thirty-six patient... | ['Alanine Transaminase', 'Aspartate Aminotransferases', 'Brazil', 'Caffeine', 'Coffee', 'Europe', 'Female', 'Hepatitis C, Chronic', 'Humans', 'Liver', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Transaminases', 'United States'] | 24,275,378 | [['D08.811.913.477.700.100'], ['D08.811.913.477.700.225'], ['Z01.107.757.176'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['Z01.542'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.12... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
Adaptive bacteria colony picking in unstructured environments using intensity histogram and unascertained LS-SVM classifier. | Features analysis is an important task which can significantly affect the performance of automatic bacteria colony picking. Unstructured environments also affect the automatic colony screening. This paper presents a novel approach for adaptive colony segmentation in unstructured environments by treating the detected pe... | ['Bacteria', 'Least-Squares Analysis', 'Support Vector Machine'] | 24,955,423 | [['B03'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['G17.035.250.500.500.500', 'L01.224.050.375.530.500.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Postoperative intensity-modulated arc therapy for cervical and endometrial cancer: a prospective report on toxicity. | PURPOSE: To report on toxicity after postoperative intensity-modulated arc therapy (IMAT) for cervical (CC) and endometrial cancer (EC).METHODS AND MATERIALS: Twenty-four CC and 41 EC patients were treated with postoperative IMAT. If indicated, para-aortic lymph node irradiation (preventive or when affected, PALN) and/... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anemia', 'Antineoplastic Agents', 'Cisplatin', 'Combined Modality Therapy', 'Endometrial Neoplasms', 'Fatigue', 'Female', 'Humans', 'Intestines', 'Leukopenia', 'Lymphatic Irradiation', 'Middle Aged', 'Nausea', 'Nocturia', 'Organs at Risk', 'Postoperative Period', 'Prospective Stu... | 22,377,596 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C15.378.071'], ['D27.505.954.248'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Glomus tumour of the oesophagus. | The authors describe a unique case of glomus tumour (glomangioma) located in the oesophagus in a 79-year-old woman. | ['Actins', 'Aged', 'Biomarkers, Tumor', 'Desmin', 'Esophageal Neoplasms', 'Female', 'Glomus Tumor', 'Humans', 'Immunohistochemistry', 'Silver Staining', 'Vimentin'] | 11,769,400 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116.100'], ['D23.101.140'], ['D05.750.078.593.200', 'D12.776.220.475.200'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['C04.557.645.350'], ['B01.050.150.900.649.313.988.400.112.40... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Visual input induces long-term potentiation of developing retinotectal synapses. | Early visual experience is essential in the refinement of developing neural connections. In vivo whole-cell recording from the tectum of Xenopus tadpoles showed that repetitive dimming-light stimulation applied to the contralateral eye resulted in persistent enhancement of glutamatergic inputs, but not GABAergic or gly... | ['2-Amino-5-phosphonovalerate', '6-Cyano-7-nitroquinoxaline-2,3-dione', 'Animals', 'Bicuculline', 'Dicarboxylic Acids', 'Light', 'Long-Term Potentiation', 'Neurons', 'Neurotransmitter Uptake Inhibitors', 'Photic Stimulation', 'Pyrrolidines', 'Retina', 'Superior Colliculi', 'Synapses', 'Visual Pathways', 'Visual Percept... | 10,862,704 | [['D12.125.070.950.100', 'D12.125.740.025'], ['D03.633.100.857.160'], ['B01.050'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['D02.241.081.337'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G11.561.638.350'], ['A08.675', 'A11.671'], ['D27.505.519.562.437', 'D27.505.519.625.600'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Analgesic efficacy of ketorolac and fentanyl in pediatric intensive care]. | OBJECTIVE: To evaluate the efficacy of the two different drugs (Ketorolac and Fentanyl), used singularly or in association, in the management of postoperative pain in Picu.STUDY DESIGN: A randomized and prospective study.METHODS: 52 children were randomly assigned to receive intravenous Ketorolac and/or Fentanyl, accor... | ['Age Factors', 'Analgesics, Non-Narcotic', 'Analgesics, Opioid', 'Anti-Inflammatory Agents, Non-Steroidal', 'Child', 'Child, Preschool', 'Critical Care', 'Data Interpretation, Statistical', 'Female', 'Fentanyl', 'Hemodynamics', 'Humans', 'Infant', 'Ketorolac', 'Male', 'Pain Measurement', 'Pain, Postoperative', 'Prospe... | 9,595,578 | [['N05.715.350.075', 'N06.850.490.250'], ['D27.505.696.663.850.014.040', 'D27.505.954.427.040.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['M01.060.... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Fatalistic beliefs about cancer prevention and three prevention behaviors. | BACKGROUND: A substantial proportion of US adults hold fatalistic beliefs about cancer prevention. Although evidence suggests that fatalistic beliefs discourage people from engaging in screening behaviors that can reduce their cancer risk, far less is known about associations between cancer fatalism and other preventio... | ['Diet', 'Educational Status', 'Exercise', 'Fear', 'Female', 'Fruit', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Health Surveys', 'Humans', 'Interviews as Topic', 'Logistic Models', 'Male', 'Marital Status', 'Middle Aged', 'Multivariate Analysis', 'Neoplasms', 'Risk Factors', 'Smoking', 'Socioeconomic... | 17,507,628 | [['G07.203.650.240'], ['N01.824.196'], ['G11.427.410.698.277', 'I03.350'], ['F01.470.361'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Combined endolaparoscopic intragastric excision for gastric neoplasms. | BACKGROUND: The aim of this study was to describe our technique of combined endolaparoscopic approach to the management of intraluminal gastric neoplasms and to review the clinical outcome.METHODS: Between February 2006 and January 2008, a total of 12 patients with gastric neoplasm < or =4 cm with a mainly intraluminal... | ['Adenoma', 'Aged', 'Aged, 80 and over', 'Carcinoma', 'Cohort Studies', 'Female', 'Gastrectomy', 'Gastrointestinal Stromal Tumors', 'Gastroscopy', 'Humans', 'Laparoscopy', 'Leiomyoma', 'Male', 'Middle Aged', 'Retrospective Studies', 'Stomach Neoplasms', 'Treatment Outcome'] | 19,645,605 | [['C04.557.470.035'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E04.210.419'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['E01.370.372.250.250.325', 'E01.370.388.250.250.250.320', 'E04.210.240.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Case management and the cost of care in the last month of life: evidence from one managed care setting. | Elderly, functionally disabled enrollees in a managed care organization were randomly assigned to case management or regular care. The service use and cost of care for the last month life for the case managed deceased is compared with that of the regular care group. The results suggest that contrary to general expectat... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Case Management', 'Cost Control', 'Cost-Benefit Analysis', 'Disabled Persons', 'Female', 'Frail Elderly', 'Health Care Costs', 'Health Status', 'Hospital Costs', 'Humans', 'Logistic Models', 'Male', 'Managed Care Programs', 'Odds Ratio', 'Ohio', 'Outpatient C... | 10,572,788 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N04.590.233.624.250'], ['N03.219.151.160'], ['N03.219.151.125'], ['M01.150'], ['M01.060.116.100.540'], ['N03.219.151.400', 'N05.300.375'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke. | BACKGROUND AND PURPOSE: Elevated plasma levels of cellular fibronectin (c-Fn) reflect vascular damage, so c-Fn might be a marker of secondary bleeding risk in cerebral ischemia. We investigated whether high plasma levels of c-Fn were associated with hemorrhagic transformation (HT) after treatment with tissue plasminoge... | ['Aged', 'Brain Ischemia', 'Female', 'Fibronectins', 'Humans', 'Intracranial Hemorrhages', 'Male', 'Matrix Metalloproteinase 9', 'Middle Aged', 'Prognosis', 'Prospective Studies', 'Risk', 'Stroke', 'Thrombolytic Therapy', 'Tissue Plasminogen Activator', 'Tomography, X-Ray Computed'] | 15,166,391 | [['M01.060.116.100'], ['C10.228.140.300.150', 'C14.907.253.092'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.535', 'C14.907.253.573', 'C23.550.414.913'], ['D08.811.277.656.300.480.205.360', 'D08.811.277... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sociomedical contributions to trachoma research and intervention. | Although the importance of human factors in the transmission and control of blinding trachoma has long been recognized, little sociomedical research has been undertaken on this disease. The trachoma literature contains considerable anecdotal information and a few reports relating to human behavioral, cultural, social, ... | ['Environment', 'Health Education', 'Health Planning', 'Humans', 'Public Health', 'Research', 'Socioeconomic Factors', 'Trachoma'] | 4,070,915 | [['G16.500.275', 'N06.230'], ['I02.233.332', 'N02.421.726.407'], ['N03.349', 'N03.706.615.302'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['H01.770.644'], ['I01.880.853.996', 'N01.824'], ['C01.150.252.289.225.800', 'C01.150.252.400.210.125.745', 'C01.375.354.220.800', ... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Epidermal growth factor receptor in vulvar malignancies and its relationship to metastasis and patient survival. | OBJECTIVE: To evaluate the level of epidermal growth factor receptor (EGF-R) expression in vulvar malignancies and to determine if a correlation exists between EGF-R levels and metastasis or patient survival.METHODS: All patients with a diagnosis of invasive squamous cell carcinoma of the vulva who were treated at our ... | ['Carcinoma, Squamous Cell', 'Disease-Free Survival', 'ErbB Receptors', 'Female', 'Humans', 'Lymphatic Metastasis', 'Survival Rate', 'Vulvar Neoplasms'] | 9,190,969 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.90... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synchronous multiple primary cancers of the stomach and duodenum in aged patients: report of two cases. | We describe herein the cases of two aged patients found to have synchronous multiple primary cancers of the stomach and duodenum. The first patient was an 82-year-old man who was preoperatively diagnosed as having gastric cancer after presenting with signs of pyloric stenosis. At laparotomy, duodenal cancer was inciden... | ['Adenocarcinoma', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Duodenal Neoplasms', 'Humans', 'Male', 'Neoplasms, Multiple Primary', 'Stomach Neoplasms', 'Treatment Outcome'] | 10,955,739 | [['C04.557.470.200.025'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['C04.588.274.476.411.445', 'C06.301.371.411.445', 'C06.405.249.411.445', 'C06.405.469.275.270', 'C06.405.469.491.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.651'], ['C04.588.27... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tunable transition from hydration to monomer-supported lubrication in zwitterionic monolayers revealed by molecular dynamics simulation. | The tribology of 2-methacryloyloxyethyl phosphorylcholine monolayers in water is studied using molecular dynamics simulations. Our results show two distinct shear regimes where the first is dominated by hydration lubrication, exhibiting near zero friction coefficients, and the second by chain-chain interactions, resemb... | ['Methacrylates', 'Molecular Dynamics Simulation', 'Phosphorylcholine', 'Silanes'] | 25,790,338 | [['D02.241.081.069.600'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D02.092.877.883.333.700', 'D02.675.276.232.700'], ['D01.837.700']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
What noseleaves do for FM bats depends on their degree of sensorial specialization. | BACKGROUND: Many bats vocalizing through their nose carry a prominent noseleaf that is involved in shaping the emission beam of these animals. To our knowledge, the exact role of these appendages has not been thoroughly investigated as for no single species both the hearing and the emission spatial sensitivities have b... | ['Animals', 'Chiroptera', 'Cues', 'Models, Biological', 'Movement', 'Nose', 'Space Perception'] | 20,808,438 | [['B01.050'], ['B01.050.150.900.649.313.937'], ['F02.463.425.234'], ['E05.599.395'], ['G07.568', 'G11.427.410'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['F02.463.593.778']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mn2+ sequestration by mitochondria and inhibition of oxidative phosphorylation. | Manganese is known to accumulate in mitochondria and in mitochondria-rich tissues in vivo. Although Ca2+ enhances mitochondrial Mn2+ uptake, ATP-bound Mn2+ is not sequestered by suspended rat brain mitochondria, and ATP binds Mn2+ even more tightly than it binds Mg2+. Physiological levels of the polyamine spermine enha... | ['Adenosine Triphosphate', 'Animals', 'Brain', 'Cations, Divalent', 'Female', 'Manganese', 'Mitochondria', 'Oxidative Phosphorylation', 'Oxygen Consumption', 'Rats', 'Rats, Inbred Strains', 'Spermine', 'Substrate Specificity'] | 1,631,887 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['A08.186.211'], ['D01.248.497.300.333'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['G02.111.665.550', 'G03.295.631', 'G03.796.550'], ['G03.680'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. | Asymmetric division of sensory organ precursors (SOPs) in Drosophila generates different cell types of the mature sensory organ. In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15, which encodes a component of the exocyst, an evolutionarily conserved ... | ['Animals', 'Drosophila', 'Drosophila Proteins', 'Endocytosis', 'Genetic Testing', 'Golgi Apparatus', 'Membrane Proteins', 'Microfilament Proteins', 'Models, Biological', 'Mutation', 'Oocytes', 'Protein Transport', 'Receptors, Notch', 'Sense Organs', 'Signal Transduction', 'Vesicular Transport Proteins', 'rab GTP-Bindi... | 16,137,928 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['G04.417'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['A11.284.430.214.190.875.336'], ['D12.776.543'], ['D05.750.078.730', 'D12.776.220.525'], ['E05.599.395'], ['G05.365.590'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. | The aim of this study was to determine whether tumor necrosis factor-alpha (TNFalpha) and receptors for TNFalpha are expressed in the exocrine pancreas, and whether pancreatic acinar cells release and respond to TNFalpha. Reverse transcription PCR, immunoprecipitation, and Western blot analysis demonstrated the presenc... | ['Animals', 'Antibodies', 'Apoptosis', 'Biological Assay', 'Cell Compartmentation', 'Cell Separation', 'Cells, Cultured', 'Ceruletide', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'NF-kappa B', 'Neutralization Tests', 'Nuclear Proteins', 'Pancreas', 'Pancreatitis', 'Precipitin Tests', 'Protein Bindin... | 9,312,187 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G04.146.954.035'], ['E05.091'], ['G04.128'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['D12.644.456.241'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.478.566.350.170', 'E05.478.566... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Seroprevalence of rubella virus in Turkish pregnant women. | OBJECTIVES: To assess the immune status of a group of Turkish pregnant women who had never been immunized.METHODS: Between June 1990 and April 1993, the seroprevelance of rubella was determined in the study group of 1351 women.RESULTS: A total of 242 (17.9%) pregnant women were found to be susceptible to rubella infect... | ['Antibodies, Viral', 'Female', 'Humans', 'Immunization', 'Pregnancy', 'Rubella Syndrome, Congenital', 'Rubella virus', 'Seroepidemiologic Studies', 'Turkey'] | 7,911,098 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['G08.686.784.769'], ['C01.925.782.930.700.700.700', 'C16.131.077.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Case-mix reimbursement for nursing home services: simulation approach. | Nursing home reimbursement based on case mix is a matter of growing interest. Several States either use or are considering this reimbursement method. In this article, we present a method for evaluating key outcomes of such a change for Connecticut nursing homes. A simulation model is used to replicate payments under th... | ['Computer Simulation', 'Connecticut', 'Diagnosis-Related Groups', 'Health Services Research', 'Medicare', 'Nursing Homes', 'Prospective Payment System', 'United States'] | 10,311,776 | [['L01.224.160'], ['Z01.107.567.875.550.200'], ['N03.219.521.710.305.200.080'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['N02.278.825.610'], ['N03.219.521.710.305.200'], ['Z01.107.567.875']] | ['Information Science [L]', 'Geographicals [Z]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
AStrap: identification of alternative splicing from transcript sequences without a reference genome. | SUMMARY: Alternative splicing (AS) is a well-established mechanism for increasing transcriptome and proteome diversity, however, detecting AS events and distinguishing among AS types in organisms without available reference genomes remains challenging. We developed a de novo approach called AStrap for AS analysis witho... | ['Alternative Splicing', 'Genome', 'Humans', 'Machine Learning', 'Sequence Analysis, RNA', 'Transcriptome'] | 30,535,139 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G05.360.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.035.250.500', 'L01.224.050.375.530'], ['E05.393.760.710'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
MicroRNA‑601 serves as a potential tumor suppressor in hepatocellular carcinoma by directly targeting PIK3R3. | Recently, microRNAs (miRNAs) have been acknowledged as important regulators of hepatocarcinogenesis and tumor progression. Therefore, identifying the underlying molecular mechanisms of miRNAs in the occurrence and development of hepatocellular carcinoma (HCC) may be important for understanding the pathogenesis of HCC a... | ['Aged', 'Carcinoma, Hepatocellular', 'Cell Movement', 'Cell Proliferation', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Male', 'MicroRNAs', 'Middle Aged', 'Neoplasm Invasiveness', 'Phosphatidylinositol 3-Kinases', 'Proto-Oncogene Proteins... | 30,664,174 | [['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.308.370'], ['G05.360.340.024.340.375.249', 'G05.360.340.024.340.415.400'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.1... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure of basement membranes in malignant melanoma and nevocytic nevi. | Basement membranes found around tumor cells in nevocytic nevi, Spitz's nevi, and malignant melanomas were analyzed by electron microscopy and antibody staining for several basement membrane proteins. Nevocytic nevi and Spitz's nevi showed a distinct, occasionally discontinuous lamina densa regardless of whether they we... | ['Antibodies', 'Basement Membrane', 'Collagen', 'Humans', 'Immunohistochemistry', 'Laminin', 'Melanoma', 'Membrane Glycoproteins', 'Membrane Proteins', 'Nevus, Pigmented', 'Skin Neoplasms'] | 2,497,191 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A10.272.220', 'A10.615.179'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.5... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary ten year results from a randomised single centre mass screening trial for abdominal aortic aneurysm. | BACKGROUND: At present, several regions and countries are considering screening for abdominal aortic aneurysm (AAA). However, The Chichester Aneurysms Screening Trial has reported poor long term benefit of screening for AAA. We therefore supplement previously published data with a preliminary analysis of the ten-year m... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Aortic Rupture', 'Bias', 'Cost-Benefit Analysis', 'Denmark', 'Elective Surgical Procedures', 'Follow-Up Studies', 'Health Care Costs', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Survival Analysis', 'Vascular Surgical Procedures'] | 16,893,663 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['C14.907.055.185.125', 'C14.907.055.239.175', 'C14.907.109.139.175', 'C26.761.125'], ['N05.715.350.150', 'N06.850.490.500'], ['N03.219.151.125'], ['Z01.542.816.124'], ['E04.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.5... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Spectral correlation parameters of neocortical potentials in the rabbit undergoing paired isorhythmic stimulation]. | At pairing of isorhythmic stimuli beyond the theta-rhythm frequency limits (3 and 8 Hz), in power spectra of EEGs of the sensorimotor and visual neocortical areas of rabbits, the frequencies are present both of the theta-range and of the stimulation frequency, in the background activity as well as during the stimulatio... | ['Animals', 'Cerebral Cortex', 'Conditioning, Classical', 'Electric Stimulation', 'Electroencephalography', 'Evoked Potentials', 'Periodicity', 'Photic Stimulation', 'Rabbits', 'Theta Rhythm', 'Time Factors'] | 3,433,925 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['F02.463.425.179.308'], ['E05.723.402'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.200.500'], ['G01.910.645', 'G07.180.562'], ['E05.723.729'], ['B01.050.150.900.649.313.968.700'], ['E01.370.376.300.150.937', 'E01.370.405.245.287.937', 'G07.265.0... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Significance of hypophyseo-thyroid disorders in chronic obstructive bronchitis]. | Blood levels of TSH, T3 and T4 were evaluated in patients suffering from aggravated chronic obstructive bronchitis (COB). Low levels of T3, T4, and T3 plus T4 were recorded in 55.4%, 13.9% and 20.8% of patients, respectively. Though TSH levels were elevated in 71.3%, its hyposecretion was present as well (in 17.8% of t... | ['Adult', 'Aged', 'Bronchitis', 'Female', 'Humans', 'Hyperpituitarism', 'Hypothyroidism', 'Lung Diseases, Obstructive', 'Male', 'Middle Aged', 'Thyrotropin', 'Thyroxine', 'Triiodothyronine'] | 2,615,305 | [['M01.060.116'], ['M01.060.116.100'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.617.738.250', 'C19.700.355'], ['C19.874.482'], ['C08.381.495'], ['M01.060.116.630'], ['D06.472.699.631.525.883', 'D12.644.548.691.525.883'], ['D06.472.9... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Binding of Yersinia enterocolitica to rabbit intestinal brush border membranes, mucus, and mucin. | Mucus and its gel-forming glycoprotein component, mucin, are thought to protect the gastrointestinal tract from enteric pathogens by inhibiting their attachment to enterocytes. In this study, we investigated interactions between Yersinia enterocolitica (isogenic strains of virulent and nonvirulent organisms) and crude ... | ['Animals', 'Bacterial Adhesion', 'Colon', 'Humans', 'In Vitro Techniques', 'Intestinal Mucosa', 'Intestine, Small', 'Male', 'Microvilli', 'Mucins', 'Rabbits', 'Rats', 'Yersinia enterocolitica'] | 2,807,525 | [['B01.050'], ['G06.099.050'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684'], ['A11.284.180.565'], ['D12.776.395.560.631'], ['B01.050.150.900.649.313.968.700'], ['B01.050.150.900.649.313.992.635.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Beliefs about smoking-related lung cancer risk among low socioeconomic individuals: the role of smoking experience and interpersonal communication. | INTRODUCTION: Previous research has documented that smoking prevalence is generally high among low socioeconomic groups and that tobacco industries continue to target these population groups. However, little research has investigated the beliefs of individuals with low socioeconomic position (SEP) about the association... | ['Awareness', 'Boston', 'Communication', 'Culture', 'Educational Status', 'Female', 'Health Promotion', 'Humans', 'Lung Neoplasms', 'Male', 'Mass Media', 'Poverty', 'Risk', 'Smoking', 'Smoking Cessation', 'Social Marketing'] | 29,110,569 | [['F02.463.188.150'], ['Z01.107.567.875.550.510.210', 'Z01.433.210'], ['F01.145.209', 'L01.143'], ['I01.076.201.450', 'I01.880.853.100'], ['N01.824.196'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['L01.178.590'], ... | ['Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Indust... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic frontal lobe epilepsy in children]. | For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 277 patients with seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic frontal lobe epilepsy (FLE), who ... | ['Adolescent', 'Anticonvulsants', 'Carbamazepine', 'Child', 'Child, Preschool', 'Epilepsy, Frontal Lobe', 'Female', 'Fructose', 'Humans', 'Male', 'Retrospective Studies', 'Topiramate', 'Treatment Outcome', 'Valproic Acid'] | 20,559,276 | [['M01.060.057'], ['D27.505.954.427.080'], ['D03.633.300.240.127'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.490.360.270', 'C10.228.140.490.493.188'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Analysis of gastric emptying dynamics in relationship to qualitative composition of intake. Comparison between normal-weight and obese subjects]. | AIMS: To analyze whether the gastric emptying profile could define obesity and to study the impact of macronutrients diet composition on gastric emptying in obese and non obese people.MATERIAL AND METHODS: 47 subjects were selected (12 non obese and 35 obese). The study was organized in 4 visits. In each visit the subj... | ['Adult', 'Body Mass Index', 'Dietary Carbohydrates', 'Dietary Fats', 'Dietary Proteins', 'Energy Intake', 'Female', 'Gastric Emptying', 'Gastrointestinal Contents', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Radiopharmaceuticals', 'Technetium Tc 99m Sulfur Colloid', 'Time Factors'] | 16,762,271 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.240.340'], ['G10.261.360.400'], ['A12.519'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients. | BACKGROUND: Estramustine phosphate sodium (EMP) frequently causes side-effects such as gastrointestinal discomfort, nausea, and edema in extremities. We analyzed single nucleotide polymorphisms (SNP) in the 17beta-hydroxysteroid dehydrogenase (HSD17B) genes, which are involved in the metabolism of EMP, to predict the r... | ['17-Hydroxysteroid Dehydrogenases', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents, Hormonal', 'Appetite', 'Edema', 'Estramustine', 'Gene Frequency', 'Genotype', 'Haplotypes', 'Humans', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Prostatic Neoplasms', 'Risk Factors'] | 15,733,111 | [['D08.811.682.047.436.375'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248.169'], ['F02.830.071', 'G07.203.650.390.070', 'G10.261.390.070'], ['C23.888.277'], ['D02.455.526.728.650.275', 'D04.210.500.365.415.248.320'], ['G05.330'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.40... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Relationship between genetic polymorphism of interleukin-6 and pneumoconiosis]. | OBJECTIVE: To explore the relationship between interleukin-6 (IL-6) (-634C/G) genetic polymorphisms and the pneumoconiosis.METHODS: A total of 104 male stage I pneumoconiosis patients diagnosed by the Pneumoconiosis Diagnosis Expert Panel according to the Chinese National Diagnosis Criteria of Pneumoconiosis (GBZ 70 - ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Interleukin-6', 'Male', 'Matched-Pair Analysis', 'Middle Aged', 'Pneumoconiosis', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length'] | 17,034,727 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.52... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Risks of therapy in infectious shock]. | On the basis of their experience in the intensive therapy unit, correlated with modern pharmacokinetic data, the authors discuss the adverse effects induced by polyvalent therapy in septic shock, and which may be listed in the group of iatrogenic pathointerference. To the biochemical and functional alterations of shock... | ['Aminocaproic Acid', 'Anti-Bacterial Agents', 'Glucocorticoids', 'Glucose Solution, Hypertonic', 'Heparin', 'Humans', 'Iatrogenic Disease', 'Oxygen Inhalation Therapy', 'Plasma Substitutes', 'Risk', 'Shock, Septic', 'Transfusion Reaction', 'Vasoconstrictor Agents'] | 653,214 | [['D02.241.081.193.150.075', 'D12.125.213.075'], ['D27.505.954.122.085'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['D26.776.314.420'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['E02.880.690'], ['D27.505.954.502.140.500'], ['E05.318.740.600.800', 'G17.680.750', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Risk factors for ectopic pregnancy in 556 pregnancies after in vitro fertilization: implications for preventive management. | OBJECTIVE: To analyze risk factors for ectopic pregnancy (EP) after in vitro fertilization (IVF).DESIGN: A retrospective study of IVF pregnancies was performed between November 1983 and December 1989.SETTING: This study was conducted in a tertiary care center, the Port-Royal University Hospital.PATIENTS: Patients' reco... | ['Adult', 'Embryo Transfer', 'Estradiol', 'Fallopian Tube Diseases', 'Fallopian Tubes', 'Female', 'Fertilization in Vitro', 'Gonadotropin-Releasing Hormone', 'Humans', 'Infertility, Female', 'Menotropins', 'Pregnancy', 'Pregnancy, Ectopic', 'Retrospective Studies', 'Risk Factors'] | 1,915,943 | [['M01.060.116'], ['E02.875.800.500', 'E05.820.800.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['C13.351.500.056.390'], ['A05.360.319.114.373', 'A13.706.500'], ['E02.875.800.750', 'E05.820.800.750'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microbiology testing associated with antibiotic dispensing in older community-dwelling adults. | BACKGROUND: It is commonly recommended that microbiological assessment should accompany the use of antibiotics prone to resistance. We sought to estimate the rate of microbiology testing and compare this to dispensing of the World Health Organization classified "watch" group antibiotics in primary care.METHODS: Data fr... | ['Aged', 'Aged, 80 and over', 'Amoxicillin-Potassium Clavulanate Combination', 'Anti-Bacterial Agents', 'Asthma', 'Bacterial Infections', 'Cohort Studies', 'Comorbidity', 'Drug Prescriptions', 'Female', 'Humans', 'Independent Living', 'Male', 'Middle Aged', 'National Health Programs', 'New South Wales', 'Pulmonary Dise... | 32,334,518 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.065.589.099.374.160.060', 'D02.065.589.099.750.750.050.050.060', 'D02.886.108.750.750.050.050.060', 'D03.633.100.300.374.160.060', 'D03.633.100.300.750.750.050.050.500', 'D26.310.102'], ['D27.505.954.122.085'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Perceptions of Illness, coping, and well-being in persons with mild cognitive impairment and their care partners. | Despite greater attention to mild cognitive impairment (MCI), little is known about reactions to this potentially threatening diagnosis among persons with MCI (PWMCI) and their care partners. Psychologic reactions, perceptions of illness, and coping responses of 46 individuals recently diagnosed with MCI and 29 care pa... | ['Adaptation, Psychological', 'Aged', 'Aged, 80 and over', 'Caregivers', 'Cognition Disorders', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Perception', 'Psychiatric Status Rating Scales'] | 18,580,593 | [['F01.058'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F03.615.250'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513'], ['F02.463.593'], ['F04.711.513.653']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ministry of health clinical practice guidelines: cancer screening. | The Ministry of Health publishes national clinical practice guidelines to provide doctors and patients in Singapore with evidence-based guidance on managing important medical conditions. This article reproduces the introduction and executive summary (with key recommendations from the guidelines) from the Ministry of He... | ['Early Detection of Cancer', 'Female', 'Health Policy', 'Humans', 'Malaysia', 'Male', 'Practice Guidelines as Topic'] | 20,358,158 | [['E01.390.500'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.487'], ['N04.761.700.350.650', 'N05.700.350.650']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Overproduction of soluble recombinant transglutaminase from Streptomyces netropsis in Escherichia coli. | A novel microbial transglutaminase (TGase) from the cultural filtrate of Streptomyces netropsis BCRC 12429 (Sn) was purified. The specific activity of the purified TGase was 18.2 U/mg protein with an estimated molecular mass of 38 kDa by sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis. The TGase gene... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Base Sequence', 'Cloning, Molecular', 'Enzyme Stability', 'Escherichia coli', 'Gene Expression', 'Molecular Sequence Data', 'Molecular Weight', 'Recombinant Proteins', 'Streptomyces', 'Transglutaminases'] | 18,810,430 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['E05.916.360', 'G02.111.700.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.297'], ['L01.453.245.667'], ['G02.494'], ['D12.776.828'], ['B03.300.390.400.810.768'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Seasonal changes in neuron numbers in the hippocampal formation of a food-hoarding bird: the black-capped chickadee. | The volume of the hippocampal formation (HF) in black-capped chickadees (Poecile atricapillus) varies across the seasons, in parallel with the seasonal cycle in food hoarding. In this study, we estimate cell density and total cell number in the HF across seasons in both juveniles and adults. We find that the seasonal v... | ['Age Factors', 'Animals', 'Behavior, Animal', 'Cell Count', 'Feeding Behavior', 'Female', 'Hippocampus', 'Male', 'Neurons', 'Seasons', 'Sex Factors', 'Songbirds'] | 10,945,896 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F01.145.113'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A08.675', 'A11.671'], ['G01.910.645.661', 'G16.500.275.071.590... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Translation and validation of a Chinese language version of the Early Childhood Oral Health Impact Scale (ECOHIS). | OBJECTIVE: This study aimed to adapt the Early Childhood Oral Health Impact Scale (ECOHIS) for pre-school children in a Chinese speaking community and to investigate its psychometric properties (validity and reliability).METHODS: A Chinese language version of the ECOHIS was derived through a forward-backward translatio... | ['Child, Preschool', 'China', 'Dental Caries', 'Family Health', 'Female', 'Humans', 'Male', 'Oral Health', 'Psychometrics', 'Quality of Life', 'Reproducibility of Results', 'Sickness Impact Profile', 'Surveys and Questionnaires', 'Tooth Eruption', 'Tooth Injuries', 'Translations'] | 19,811,551 | [['M01.060.406.448'], ['Z01.252.474.164'], ['C07.793.720.210'], ['N01.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.400.535'], ['F04.711.780'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.308.9... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Informa... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
[An enlarged neck fold: a sonographic marker of Down's syndrome]. | We report about one case of twin pregnancy where one fetus is healthy and the other has Trisomie 21. The one large skin fold on the neck is observe in the ultrasound. This ultrasound finds is noticed in the Ullrich-Turner-Syndrome as well as in the Down Syndrome. The Trisomie 21 was ascertained after the birth. The cli... | ['Adult', 'Diseases in Twins', 'Down Syndrome', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Neck', 'Pregnancy', 'Prenatal Diagnosis', 'Ultrasonography'] | 2,975,089 | [['M01.060.116'], ['C23.550.291.750'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A01.598'], ['G08.686.784.769'], ['E01.370.378.630'], ['E01.370.350.850']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. | PURPOSE: We evaluated fundus and fluorescein angiography (FAG) findings and characteristics that can help distinguish nonarteritic anterior ischemic optic neuropathy (NAION) from optic neuritis (ON).METHODS: Twenty-three NAION patients and 17 ON with disc swelling patients were enrolled in this study. We performed fund... | ['Choroid', 'Female', 'Fluorescein Angiography', 'Fundus Oculi', 'Humans', 'Male', 'Middle Aged', 'Optic Disk', 'Optic Neuritis', 'Optic Neuropathy, Ischemic', 'Photography', 'Retrospective Studies'] | 27,478,356 | [['A09.371.894.223'], ['E01.370.370.050.350', 'E01.370.380.250'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['C10.292.700.550', 'C11.640.576'], ['C10.292.700.600', 'C11.640.643', 'C14.907.601'], ['E01.370.350.600', 'E05.712... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Early postresuscitation centralization of the blood circulation]. | Experiments on cats were made to study the cardiac output and its main fractions supplying blood to the epi- and subdiaphragmal parts of the body during the postresuscitation period. The phenomenon of early postresuscitation centralization of circulation was established, correlating with the gravity of the sustained te... | ['Animals', 'Blood Circulation', 'Cardiac Output', 'Cats', 'Resuscitation', 'Time Factors'] | 3,986,332 | [['B01.050'], ['G09.330.100'], ['E01.370.370.380.150', 'G09.330.380.124'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E02.365.647'], ['G01.910.857']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Haplotype analysis of identical factor IX mutants using PCR. | We have detected the mutations in the factor IX genes from all of the haemophilia B patients registered at Malm? haemophilia centre and are currently examining the entire UK haemophilia B population. From these studies we have found 13 base substitutions which have recurred in 1-6 other, presumably unrelated, patients.... | ['Amino Acid Sequence', 'Base Sequence', 'DNA', 'DNA Mutational Analysis', 'Factor IX', 'Haplotypes', 'Hemophilia B', 'Humans', 'Male', 'Molecular Sequence Data', 'Polymerase Chain Reaction'] | 1,615,486 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['E05.393.760.700.300'], ['D08.622.355', 'D12.776.124.125.375', 'D12.776.811.243.355', 'D23.119.375'], ['G05.380.360'], ['C15.378.100.100.510', 'C15.378.100.141.510', 'C15.378.463.510', 'C16.320.099.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Co-grafting of antiadhesive and antimicrobial agents onto UV-micropatterned copper surfaces. | Adhesion of proteins and bacteria was reduced by a factor close to one order of magnitude, and adhered bacteria were dramatically damaged on copper surfaces by grafting a PEG-modified PMMA-based (polymethyl methacrylate) copolymer together with an antimicrobial peptide. To obtain PEG and a peptide grafted together on t... | ['Anti-Infective Agents', 'Bacterial Adhesion', 'Copper', 'Microscopy, Atomic Force', 'Photoelectron Spectroscopy', 'Surface Properties', 'Ultraviolet Rays'] | 26,613,864 | [['D27.505.954.122'], ['G06.099.050'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['E05.196.867.618'], ['G02.860'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Potentiation of hyperphagia and relief of hypothermia in the genetically obese mouse (genotype, ob/ob) by alpha-methyl tyrosine. | DL-alpha-methyl-p-tyrosine methyl ester hydrochloride affected the hyperphagia and hypothermia characteristic of the genetically obese mouse (genotype, ob/ob) throughout an experimental period of 5 days. Intraperitoneal injections of 100 mg/kg body weight, daily, resulted in a significant increase in the average daily ... | ['Animals', 'Appetite', 'Body Temperature', 'Body Weight', 'Enzyme Inhibitors', 'Feeding Behavior', 'Feeding and Eating Disorders', 'Genotype', 'Humans', 'Hypothalamus', 'Injections, Intraperitoneal', 'Mice', 'Norepinephrine', 'Obesity', 'Stimulation, Chemical', 'Tyrosine 3-Monooxygenase'] | 31,336 | [['B01.050'], ['F02.830.071', 'G07.203.650.390.070', 'G10.261.390.070'], ['E01.370.600.875.374', 'G07.110'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D27.505.519.389'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F03.400'], ['G05... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessing the sensitivity of the polio environmental surveillance system. | BACKGROUND: The polio environmental surveillance (ES) system has been an incredible tool for advancing polio eradication efforts because of its ability to highlight the spatial and temporal extent of poliovirus circulation. While ES often outperforms, or is more sensitive than AFP surveillance, the sensitivity of the E... | ['Afghanistan', 'Environmental Monitoring', 'Humans', 'Models, Theoretical', 'Pakistan', 'Poliomyelitis', 'Poliovirus Vaccine, Oral', 'Population Surveillance'] | 30,592,720 | [['Z01.252.245.500.125'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['Z01.252.245.723'], ['C01.207.618.750', 'C01.925.782.687.359.764', 'C10.228.228.618.750', 'C10.228.854.525.850', 'C10.668.864'], ['D20.215.894.899.623.750'], ['E05.318.308.980.438.700', '... | ['Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Revision of total hip arthroplasty in octogenarians. | Twenty-seven revision total hip arthroplasties were performed in patients who were at least eighty years old. The average duration of follow-up was five years. There were no perioperative deaths, and only 11 per cent (three) of the patients had a major complication; all of the complications resolved. The only re-revisi... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Female', 'Hip Prosthesis', 'Humans', 'Male', 'Reoperation', 'Treatment Outcome'] | 7,713,976 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.690'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Relief of knee flexion contracture and gait improvement following adaptive training for an assist device in a transtibial amputee: A case study. | BACKGROUND: Management of a knee contracture is important for regaining gait ability in transtibial amputees. However, there has been little study of prosthesis training for enhancing mobility and improving range of motion in cases of restricted knee extension.OBJECTIVE: This study aimed to evaluate the effects of adap... | ['Amputees', 'Artificial Limbs', 'Biomechanical Phenomena', 'Contracture', 'Exercise Test', 'Exercise Therapy', 'Gait', 'Humans', 'Knee Joint', 'Male', 'Range of Motion, Articular', 'Treatment Outcome', 'Walking'] | 28,282,797 | [['M01.150.100'], ['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['G01.154.090', 'G01.374.089'], ['C05.550.323', 'C05.651.197'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Immunological parameters on prophase of severe hepatitis B]. | OBJECTIVE: To study cellular and humoral immune status on prophase of severe hepatitis B (PSHB).METHODS: 56 cases of PSHB patients, 40 cases of chronic hepatitis B (CHB) patients and 20 cases of healthy volunteers were enrolled for detection of CD3+, CD4+, CD8+ and CD3-/CD19+ (B cells) lymphocyte subsets in peripheral ... | ['Adult', 'Antibodies, Viral', 'Complement C3', 'Female', 'Flow Cytometry', 'Hepatitis B, Chronic', 'Humans', 'Lymphocyte Count', 'Male', 'Middle Aged', 'T-Lymphocyte Subsets', 'Young Adult'] | 24,645,326 | [['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dermoscopic and clinical features of pigmented skin lesions of the genital area. | BACKGROUND: The dermoscopic features of vulvar melanosis lesions are well known. To our knowledge, there are only a few case reports about dermoscopic features of pigmented genital lesions in male patients.OBJECTIVE: To evaluate dermoscopic and clinical characteristics of benign lesions of the genital area in both male... | ['Adolescent', 'Adult', 'Age Factors', 'Biopsy', 'Dermoscopy', 'Female', 'Humans', 'Keratosis, Seborrheic', 'Male', 'Melanosis', 'Nevus, Pigmented', 'Penile Diseases', 'Sex Factors', 'Skin', 'Skin Neoplasms', 'Vulvar Diseases', 'Young Adult'] | 25,830,986 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.350.515.277.250', 'E05.595.185.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury. | Methylmercury (MeHg) is a ubiquitous and persistent neurotoxin that poses a risk to human health. Although the mechanisms of MeHg toxicity are not fully understood, factors that contribute to susceptibility are even less well known. Studies of human gene polymorphisms have identified a potential role for the multidrug ... | ['ATP-Binding Cassette Transporters', 'Animals', 'Base Sequence', 'DNA Primers', 'Drosophila', 'Gene Knockdown Techniques', 'Larva', 'Methylmercury Compounds', 'Polymerase Chain Reaction', 'Teratogens'] | 24,863,968 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['E05.393.335.500'], ['B05.500.500', 'G07.34... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121. | The novel cocaine analog RTI-121 [3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester] was evaluated as a probe for the in vitro labeling and localization of the dopamine transporter in the human brain. Saturation binding experiments conducted in sucrose-phosphate buffer (10 mM sodium phosphate, pH 7.4,... | ['Adult', 'Autoradiography', 'Binding Sites', 'Binding, Competitive', 'Brain', 'Carrier Proteins', 'Cocaine', 'Dopamine Plasma Membrane Transport Proteins', 'Female', 'Humans', 'Iodine Radioisotopes', 'Male', 'Membrane Glycoproteins', 'Membrane Transport Proteins', 'Nerve Tissue Proteins', 'Tissue Distribution'] | 8,869,167 | [['M01.060.116'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A08.186.211'], ['D12.776.157'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['D12.776.157.530.450.625.124', 'D12.776.15... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression of TGF-â1 and CTGF Is Associated with Fibrosis of Denervated Sternocleidomastoid Muscles in Mice. | Injury to the recurrent laryngeal nerve often leads to permanent vocal cord paralysis, which has a significant negative impact on the quality of life. Long-term denervation can induce laryngeal muscle fibrosis, which obstructs the muscle recovery after laryngeal reinnervation. However, the mechanisms of fibrosis remain... | ['Actins', 'Animals', 'Blotting, Western', 'Connective Tissue Growth Factor', 'Fibrosis', 'Gene Expression Regulation', 'Male', 'Mice, Inbred C57BL', 'Muscles', 'RNA, Messenger', 'Transforming Growth Factor beta1'] | 26,686,381 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.644.276.200.100', 'D12.776.467.200.100', 'D12.776.860.300.200.100', 'D23.529.237.100'], ['C23.550.355'], ['G05.308'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti-ulcer constituents of Annona squamosa twigs. | Phytochemical investigation of Annona squamosa twigs, resulted in isolation and identification of twelve known (1-12) compounds among them one 1-(4-â-D-glucopyranosyloxyphenyl)-2-(â-D-glucopyranosyloxy)-ethane (11) is synthetically known but first time isolated from natural sources. Their structures were elucidated usi... | ['Animals', 'Annona', 'Anti-Ulcer Agents', 'Aporphines', 'Aspirin', 'Benzylisoquinolines', 'Berberine Alkaloids', 'Cold Temperature', 'Dinoprostone', 'Disaccharides', 'Drug Evaluation, Preclinical', 'Duodenal Ulcer', 'Ethanol', 'Gastric Juice', 'Gastrins', 'Guinea Pigs', 'H(+)-K(+)-Exchanging ATPase', 'Histamine', 'Lig... | 21,342,663 | [['B01.050'], ['B01.650.940.800.575.912.250.065.500'], ['D27.505.954.483.203'], ['D03.132.098.038', 'D03.633.100.531.085.030', 'D03.633.400.095'], ['D02.455.426.559.389.657.410.595.176'], ['D03.132.098', 'D03.633.100.531.085'], ['D03.132.098.057', 'D03.633.400.168'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Functional deterioration secondary to hospitalization for an acute disease in the elderly. An analysis of its incidence and the associated risk factors]. | OBJECTIVE: To determine the incidence of functional impairment at hospital admission and after hospital discharge, and to identify those factors that could be predictors of such impairment in a cohort of elderly people with high level of independence in the basic activities of daily living (BADL).DESIGN: Epidemiologic,... | ['Activities of Daily Living', 'Acute Disease', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Frail Elderly', 'Hospitalization', 'Humans', 'Incidence', 'Male', 'Patient Discharge', 'Prospective Studies', 'Risk Factors', 'Spain'] | 10,481,556 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['M01.06... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Endoscopy in patients with malignant conditions of the gastrointestinal tract. | Two hundred and fifteen consecutive upper gastrointestinal endoscopies were performed. It is evident that the patient population in our setting is quite different when compared with that of a general hospital. The incidence of both gastrointestinal hemorrhage and unknown primary malignant tumor is high. In this group o... | ['Adenocarcinoma', 'Adult', 'Aged', 'Diagnosis, Differential', 'Duodenal Ulcer', 'Endoscopy', 'Esophagoscopy', 'Female', 'Gastrointestinal Diseases', 'Gastrointestinal Neoplasms', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Peptic Ulcer', 'Rhabdomyosarcoma', 'Stomach Neoplasms'] | 1,242,545 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['E01.171'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['E01.370.388.250', 'E04.502.250'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.240.250.260', 'E04.502.250.250.250.260'], ['C06.405'], ['C04.588.274.476', 'C06.301.371... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Scanning electron microscopy of ciliary muscle of monkey eye. | The three-dimensional structure of the ciliary muscles of the cynomolgus monkey eye was studied by scanning electron microscopy after the treatment of the muscle in 8 N hydrochloric acid. The meridional muscle bundles in the outer part of the ciliary body were closely arranged and multilayered, extending in a straight ... | ['Animals', 'Ciliary Body', 'Macaca fascicularis', 'Microscopy, Electron', 'Microscopy, Electron, Scanning', 'Muscles'] | 3,586,402 | [['B01.050'], ['A09.371.060.160', 'A09.371.894.280'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['E01.370.350.515.402', 'E05.595.402'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A02.633', 'A10.690']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury. | Following peripheral nerve injury repair, improved behavioural outcome may be the most important evidence of functionality of axon regeneration after any repair strategy. A range of behavioural testing paradigms have been developed for peripheral nerve injury research. Complete injury of the adult rat sciatic nerve is ... | ['Analysis of Variance', 'Animals', 'Behavior, Animal', 'Body Weight', 'Disease Models, Animal', 'Female', 'Functional Laterality', 'Gait', 'Gait Disorders, Neurologic', 'Neurologic Examination', 'Psychomotor Performance', 'Rats', 'Rats, Inbred Lew', 'Recovery of Function', 'Sciatic Neuropathy'] | 18,577,402 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['F01.145.113'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F02.830.297.425', 'G11.561.225.425'], ['E01.370.600.250'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: A retrospective cohort analysis. | OBJECTIVES: Development of leptomeningeal metastasis (LM) in non-small cell lung cancer (NSCLC)-patients is associated with a poor prognosis. It has been suggested that LM-patients with epidermal growth factor receptor mutated (EGFR+) NSCLC have a superior prognosis compared to EGFR-wild type NSCLC. Studies in EGFR+ NS... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Cohort Studies', 'Combined Modality Therapy', 'ErbB Receptors', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Meningeal Neoplasms', 'Middle Aged', 'Mutation', 'Neoplasm Staging', 'Protein Kinase Inhibitors', 'Retrospecti... | 26,117,231 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.186'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prolonged morphometric study of barnacles grown on soft substrata of hydrogels and elastomers. | A long-term investigation of the shell shape and the basal morphology of barnacles grown on tough, double-network (DN) hydrogels and polydimethylsiloxane (PDMS) elastomer was conducted in a laboratory environment. The elastic modulus of these soft substrata varied between 0.01 and 0.47 MPa. Polystyrene (PS) (elastic mo... | ['Animals', 'Biofouling', 'Dimethylpolysiloxanes', 'Elastomers', 'Hardness', 'Hydrogels', 'Surface Properties', 'Thoracica'] | 24,447,274 | [['B01.050'], ['G16.500.100', 'N06.850.460.150', 'N06.850.540.500'], ['D02.756.650.700.150', 'D05.750.900.850.150', 'D25.720.900.850.150', 'J01.637.051.720.900.850.150'], ['D25.720.327', 'J01.637.051.720.327', 'J01.637.412'], ['G01.374.647'], ['D20.280.320.375', 'D26.255.165.320.375'], ['G02.860'], ['B01.050.500.131.36... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Controllable synthesis and characterization of porous polyvinyl alcohol/hydroxyapatite nanocomposite scaffolds via an in situ colloidal technique. | During the last decades, there have been several attempts to combine bioactive materials with biocompatible and biodegradable polymers to create nanocomposite scaffolds with excellent biocompatibility, bioactivity, biodegradability and mechanical properties. In this research, the nanocomposite scaffolds with compositio... | ['Biocompatible Materials', 'Cell Line, Tumor', 'Cells, Cultured', 'Durapatite', 'Humans', 'Microscopy, Electron, Transmission', 'Nanocomposites', 'Polyvinyl Alcohol', 'Porosity', 'Spectroscopy, Fourier Transform Infrared', 'Tissue Engineering'] | 21,310,596 | [['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.580', 'E05... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of breathing on ductus arteriosus blood flow directly after birth. | Spontaneous breathing at birth influences ductus arteriosus (DA) flow. This study quantifies the effect of breathing on DA shunting directly after birth. In healthy term infants born by elective cesarean section, simultaneous measurements of DA shunting and tidal volumes during spontaneous breathing were performed at 2... | ['Blood Flow Velocity', 'Ductus Arteriosus', 'Humans', 'Infant, Newborn', 'Pulmonary Circulation', 'Respiration', 'Tidal Volume'] | 28,879,564 | [['E01.370.370.130', 'G09.330.380.630.080'], ['A07.541.278.395', 'A16.378.303.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G09.330.100.770', 'G09.772.593'], ['G09.772.705'], ['E01.370.386.700.485.750.900.350.750', 'G09.772.850.970.500.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor. | Dehydroepiandrosterone sulfate (DHEAS) and estrone sulfate (E1S) are two of the most abundant steroids in the human circulation. The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone. In the current study we aimed at... | ['Animals', 'CHO Cells', 'Cell Death', 'Cricetinae', 'Cricetulus', 'Dehydroepiandrosterone Sulfate', 'Estrogens', 'Estrone', 'Female', 'Fluorocarbons', 'Humans', 'Male', 'Receptors, Androgen', 'Receptors, Estrogen', 'Serum', 'Transcriptional Activation'] | 26,666,359 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['G04.146'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['D04.210.500.054.079.429.625.300', 'D04.210.500.578.502.400.300', 'D06.472.040.502.400.300', 'D06.472.334.851.968.952.300'], ['D27.505.696.399.472.277'], ['D04.21... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correction of the prominent occiput in Beckwith-Wiedemann syndrome. | A peculiar prominence of the occiput is a variable feature of Beckwith-Wiedemann syndrome. Careful examination of the anatomy of this calvarial deformity in a recent case permitted an uncomplicated and gratifying surgical correction. | ['Beckwith-Wiedemann Syndrome', 'Craniotomy', 'Follow-Up Studies', 'Humans', 'Infant', 'Male', 'Occipital Bone', 'Suture Techniques'] | 2,488,951 | [['C16.131.077.133', 'C16.131.260.080', 'C16.320.180.080'], ['E04.525.190'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A02.835.232.781.572'], ['E04.987.775']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Identifying hearing impairment among older adults. | A survey of older-young and younger-old adults (ages 45-64) was conducted to identify the existence of a hearing impairment as described by a self-administered hearing test. Seventy of 96 surveys were returned yielding a response rate of 73%. The results indicated that the younger age group (ages 45-54) scored lower on... | ['Aged', 'Communication', 'Dental Care for Aged', 'Female', 'Hearing Disorders', 'Hearing Tests', 'Humans', 'Male', 'Middle Aged', 'Ohio', 'Pennsylvania', 'West Virginia'] | 1,856,750 | [['M01.060.116.100'], ['F01.145.209', 'L01.143'], ['E06.170.100', 'N02.421.240.190.210'], ['C09.218.458', 'C10.597.751.418', 'C23.888.592.763.393'], ['E01.370.382.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Poor prognosis of patients with stage Ib1 adenosquamous cell carcinoma of the uterine cervix with pelvic lymphnode metastasis. | From January 1990 to December 2004, the prognosis of 28 patients with stage Ib1 adenosquamous cell carcinoma (ASC) were assessed in comparison with those of matched counterparts of pure adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The mean ages were 46.6, 48.3, and 48.5 years for patients with ASC, ADC, and ... | ['Adenocarcinoma', 'Carcinoma, Adenosquamous', 'Chemotherapy, Adjuvant', 'Female', 'Humans', 'Hysterectomy', 'Lymph Node Excision', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Staging', 'Pelvis', 'Prognosis', 'Retrospective Studies', 'Survival Rate', 'Uterine Cervical Neoplasms'] | 16,547,424 | [['C04.557.470.200.025'], ['C04.557.435.250', 'C04.557.470.200.150'], ['E02.186.170', 'E02.319.170'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E04.446'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['E01.789.625'], ['A01.923.600'], ['E01.789'], ['E05.318.372.500.500.5... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhanced cholinergic cutaneous vasodilation in Raynaud's phenomenon. | BACKGROUND: Vasodilator function was determined in patients with Raynaud's phenomenon during intra-arterial infusions of the endothelium-dependent and -independent vasodilators, methacholine and sodium nitroprusside, respectively. Reactive hyperemia, induced by 5 minutes of arterial occlusion with exercise, was also me... | ['Adult', 'Blood Vessels', 'Endothelium, Vascular', 'Female', 'Fingers', 'Forearm', 'Humans', 'Laser-Doppler Flowmetry', 'Male', 'Methacholine Chloride', 'Nitroprusside', 'Plethysmography', 'Raynaud Disease', 'Regional Blood Flow', 'Skin', 'Vasodilation'] | 8,124,805 | [['M01.060.116'], ['A07.015'], ['A07.015.700.500', 'A10.272.491.355'], ['A01.378.800.667.430'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['D02.092.877.883.555.500', 'D02.675.276.534.500'], ['D01.248.497.158.291.350.550', 'D01.490.100.300.550', 'D01.625.40... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mucocutaneous autoimmune syndrome following fludarabine therapy for low-grade non-Hodgkin's lymphoma of B-cell type (B-NHL). | A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with ... | ['Adult', 'Antineoplastic Agents', 'Autoimmunity', 'Humans', 'Immunosuppressive Agents', 'Lymphoma, B-Cell', 'Male', 'Skin Diseases', 'Syndrome', 'Vidarabine'] | 9,433,380 | [['M01.060.116'], ['D27.505.954.248'], ['G12.450.192'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['C04.557.386.480.150', 'C15.604.515.569.480.150', 'C20.683.515.761.480.150'], ['C17.800'], ['C23.550.288.500'], ['D03.633.100.759.590.138.900', 'D13.570.065.950', 'D13.570.583.138.900']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Clinical significance of micrometastases in patients with esophageal cancer]. | Hematoxylin and eosin (HE) and immunohistochemical (IHC) staining have been commonly used in combination with thin serial sectioning of frozen and paraffin-embedded specimens for the detection of micrometastatic disease in the lymph nodes of patients with esophageal cancer. The application of IHC has markedly improved ... | ['Esophageal Neoplasms', 'Humans', 'Neoplasm Micrometastasis', 'Sentinel Lymph Node Biopsy'] | 23,457,938 | [['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.695', 'C23.550.727.650.695'], ['E01.370.225.500.384.100.580', 'E01.370.225.998.054.580', 'E01.370.388.100.580', 'E04.074.580', 'E04.446.819', 'E05.200.500.... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyperostosis of anterior cervical vertebrae: a rare cause of dysphagia. | Recently, we treated two cases of dysphagia as a result of anterior cervical osteophytes. The cases were the result of two different aetiologies. Referral was delayed in one case because a general practitioner was under the impression that the condition was untreatable. The aetiology, diagnosis and treatment are discus... | ['Aged', 'Cervical Vertebrae', 'Deglutition Disorders', 'Humans', 'Hyperostosis, Diffuse Idiopathic Skeletal', 'Male', 'Radiography', 'Spinal Osteophytosis'] | 3,262,813 | [['M01.060.116.100'], ['A02.835.232.834.151'], ['C06.405.117.119', 'C09.775.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.540.410', 'C05.116.900.815.651'], ['E01.370.350.700'], ['C05.116.900.815']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An electronic portal imaging device for transit dosimetry. | An electronic portal imaging device has been designed and constructed. It consists of an array of 128 CsI scintillation crystals coupled to photodiodes which is scanned across the field in 4 seconds. The linac is operated at a dose rate of 400 cGy min-1 and the dose delivered for image acquisition is approximately 27 c... | ['Biophysical Phenomena', 'Biophysics', 'Female', 'Head', 'Humans', 'Image Processing, Computer-Assisted', 'Mammography', 'Phantoms, Imaging', 'Radiotherapy, Computer-Assisted'] | 9,394,412 | [['G01.154'], ['H01.158.344', 'H01.671.100'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.700.500'], ['E07.671'], ['E02.815.635', 'L01.313.500.750.100.710.600']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect. | The Saccharomyces cerevisiae gene PPR1 encodes a positive regulator of the expression of the two unlinked structural genes URA1 and URA3. The gene has been mapped to a position 6.5 cM from the centromere of chromosome XII. Uninducible alleles have been selected and used to establish a meiotic map. Suppressible alleles ... | ['Alleles', 'Base Sequence', 'Chromosome Mapping', 'Dihydroorotate Oxidase', 'Genes', 'Genes, Dominant', 'Genes, Fungal', 'Genes, Recessive', 'Genes, Regulator', 'Genetic Complementation Test', 'Mutation', "Orotidine-5'-Phosphate Decarboxylase", 'Pyrimidines', 'Saccharomyces cerevisiae', 'Suppression, Genetic'] | 6,096,562 | [['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['D08.811.682.660.300'], ['G05.360.340.024.340'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['G05.360.340.024.340.415', 'G05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Dual Functioning Thieno-Pyrrole Fused BODIPY Dyes for NIR Optical Imaging and Photodynamic Therapy: Singlet Oxygen Generation without Heavy Halogen Atom Assistance. | We discovered a rare phenomenon wherein a thieno-pyrrole fused BODIPY dye (SBDPiR690) generates singlet oxygen without heavy halogen atom substituents. SBDPiR690 generates both singlet oxygen and fluorescence. To our knowledge, this is the first example of such a finding. To establish a structure-photophysical property... | ['Animals', 'Apoptosis', 'Boron Compounds', 'Cell Line, Tumor', 'Crystallography, X-Ray', 'Drug Design', 'Fluorescent Dyes', 'Halogens', 'Heterocyclic Compounds, 4 or More Rings', 'Humans', 'Lasers', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Molecular Conformation', 'Neoplasms', 'Photochemotherapy', 'Photosensitizi... | 25,779,683 | [['B01.050'], ['G04.146.954.035'], ['D01.132', 'D02.203'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.309.742.225'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D01.268.380'], ['D03.633.400'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Absence of human papillomavirus infection in minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia. | The human papillomavirus (HPV) is basically always detected in squamous cell carcinoma of the cervix and its precursors; a high incidence of HPV also has been reported in adenocarcinoma and adenocarcinoma in situ of the uterine cervix. Lobular endocervical glandular hyperplasia (LEGH) was first described by Nucci in 19... | ['Adenocarcinoma', 'Aged', 'DNA, Viral', 'Female', 'Histocytochemistry', 'Humans', 'Middle Aged', 'Neoplasms, Glandular and Epithelial', 'Papillomaviridae', 'Papillomavirus Infections', 'Polymerase Chain Reaction', 'Retrospective Studies', 'Tumor Virus Infections', 'Uterine Cervical Neoplasms'] | 15,968,208 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['D13.444.308.568'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.470'], ['B04.280.210.655'... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy and safety of combined diclofenac 0.1% and gentamicin 0.3% eyedrops after phacoemulsification. | PURPOSE: To study the efficacy of combined diclofenac 0.1% and gentamicin 0.3% (Digen) eyedrops to treat postoperative inflammation and prevent ocular infection in eyes having phacoemulsification.SETTING: Department of Ophthalmology, University of Milan, San Paolo Hospital, Milan; Eye Clinic, University of Verona; and ... | ['Administration, Topical', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Anti-Inflammatory Agents, Non-Steroidal', 'Diclofenac', 'Double-Blind Method', 'Drug Therapy, Combination', 'Endophthalmitis', 'Eye Infections, Bacterial', 'Female', 'Gentamicins', 'Humans', 'Male', 'Middle Aged', 'Ophthalmic Solutions',... | 9,278,797 | [['E02.319.267.120'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.241.223.601.210'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.310'], ['C01.375.265', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kinetics of finite dose absorption through skin 1. Vanillylnonanamide. | Despite the considerable success in predicting the steady-state dermal absorption rates of chemical compounds from large reservoirs applied to skin, correspondingly little progress has been made in predicting the absorption rate and extent for small doses of topically applied compounds. In the latter case, steady-state... | ['Animals', 'Diffusion', 'Humans', 'Skin Absorption', 'Vanillic Acid'] | 11,169,537 | [['B01.050'], ['G01.202', 'G02.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.750', 'G03.787.024.500.750', 'G07.690.725.015.500.750', 'G13.750.778'], ['D02.241.223.100.300.350.875', 'D02.241.511.390.350.875', 'D02.455.426.559.389.127.281.350.875', 'D02.455.426.559.389.657.654.638.875']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell culture models for oscillator and pacemaker function: recipes for dishes with circadian clocks? | Primary cell cultures of avian pinealocytes and the mammalian suprachiasmatic nucleus (SCN), immortalized cell lines derived from the SCN (SCN2.2), and fibroblasts derived from mice and rats have been employed as in vitro models to study the cellular and molecular mechanisms underlying circadian biological clocks. This... | ['Animals', 'Arylalkylamine N-Acetyltransferase', 'Biological Clocks', 'Cell Culture Techniques', 'Cells, Cultured', 'Chickens', 'Circadian Rhythm', 'Coculture Techniques', 'Fibroblasts', 'Mice', 'Models, Animal', 'Motor Activity', 'Pineal Gland', 'Rats', 'Suprachiasmatic Nucleus'] | 15,817,312 | [['B01.050'], ['D08.811.913.050.134.127'], ['G07.180.562.094'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.180.562.190'], ['E05.481.500.374'], ['A11.329.228'], ['B01.050.150.900.649.313.992.635.505.500'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of exposure to dibutyryl cyclic adenylic acid on the membrane antigenicity of SV40 tumor cells. | When SV40 tumor cells (F5-1) in culture were treated with dibutyryl cyclic adenylic acid (DbcAMP),marked alterations occurred in their growth and morphology. Additionally, the incorporation or uptake of labeled thymidine, uridine, phenylalanine, and choline were reduced by this treatment. These modifications with DbcAM... | ['Animals', 'Antigens, Neoplasm', 'Bucladesine', 'Cell Division', 'Cell Membrane', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Cricetinae', 'Immunization', 'Phenotype', 'Simian virus 40'] | 184,950 | [['B01.050'], ['D23.050.285'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.149'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[B. Parenteral feeding. Metabolic dysfunction in the postoperative and post-traumatic phase]. | A fundamental knowledge of postaggression metabolism, i.e., postoperative and posttraumatic metabolism, is necessary for prophylaxis and treatment of its deleterious dysfunctions. These may be due to disturbed regulation of the water, electrolyte, and acid-base balance, the oxygen supply to cells, energy metabolism as ... | ['Acid-Base Imbalance', 'Energy Metabolism', 'Humans', 'Oxygen Consumption', 'Postoperative Complications', 'Postoperative Period', 'Proteins', 'Trace Elements', 'Vitamins', 'Water-Electrolyte Imbalance', 'Wounds and Injuries'] | 732,458 | [['C18.452.076'], ['G03.295'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.680'], ['C23.550.767'], ['E04.614.750', 'N02.421.585.753.750'], ['D12.776'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555'], ['D27.505.696.494.600', 'G07.203.300.681.500.600', 'J02.500.681.500... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Evidence of the involvement of cerebral renin-angiotensin in stress analgesia. | Studies concerning the variations of the central renin-angiotensin system (RAS) during the immobilization stress in rats have shown a significant increase of the renin-like activity in the hypothalamus and the fronto-parietal cortex together with a manifest decrease in hypophysis and pineal gland. The resulted stress, ... | ['Analgesia', 'Angiotensin II', 'Animals', 'Brain', 'Dexamethasone', 'Naloxone', 'Pain', 'Pineal Gland', 'Pituitary Gland', 'Rats', 'Renin', 'Renin-Angiotensin System', 'Restraint, Physical', 'Saralasin', 'Sensory Thresholds', 'Stress, Psychological'] | 3,931,111 | [['E03.091'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['A08.186.211'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of eicosapentaenoic acid by high cell density cultivation of the marine oleaginous diatom Fistulifera solaris. | Polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA), have attracted attention owing to their health benefits for humans, as well as their importance in aquaculture and animal husbandry. Establishing a sustainable PUFA supply based on fish oils has been difficult due to their increasing demand. Th... | ['Cell Count', 'Diatoms', 'Eicosapentaenoic Acid', 'Fatty Acids, Unsaturated', 'Humans', 'Microalgae'] | 28,898,857 | [['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['B01.750.200'], ['D10.212.302.380.410.385', 'D10.251.355.255.200', 'D10.251.355.337.290', 'D10.627.430.450.390'], ['D10.251.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B05.080.500.600.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Large-scale synthesis and characterization of hexagonal prism-shaped SiC nanowires. | Abundant hexagonal prism-shaped SiC nanowires were synthesized on graphite substrate via heating silicon in a graphite crucible. The products were characterized using X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron... | ['Carbon Compounds, Inorganic', 'Crystallization', 'Macromolecular Substances', 'Materials Testing', 'Molecular Conformation', 'Nanostructures', 'Nanotechnology', 'Particle Size', 'Silicon Compounds', 'Surface Properties'] | 18,572,627 | [['D01.200'], ['E05.196.300', 'G02.171'], ['D05'], ['E05.570'], ['G02.111.570.820'], ['J01.637.512'], ['H01.603', 'J01.897.520.600'], ['G02.712'], ['D01.837'], ['G02.860']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Heparin-like dextran derivatives as well as glycosaminoglycans inhibit the enzymatic activity of human cathepsin G. | Some synthetic dextran derivatives that mimic the action of heparin/heparan sulfate were previously shown to inhibit neutrophil elastase and plasmin. Here we report that these derivatized dextrans also inhibit cathepsin G (CatG). Dextran containing carboxymethyl and benzylamide groups (RG1150) as well as those containi... | ['Cathepsin G', 'Cathepsins', 'Dermatan Sulfate', 'Dextrans', 'Enzyme Inhibitors', 'Glycosaminoglycans', 'Heparin', 'Heparitin Sulfate', 'Humans', 'Kinetics', 'Serine Endopeptidases', 'Substrate Specificity'] | 12,606,025 | [['D08.811.277.656.224.350', 'D08.811.277.656.300.760.066', 'D08.811.277.656.959.350.066'], ['D08.811.277.656.224'], ['D09.698.373.200.380'], ['D05.750.078.562.272', 'D09.698.365.272'], ['D27.505.519.389'], ['D09.698.373'], ['D09.698.373.400'], ['D09.698.373.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
OSA and the bariatric patient. | Mrs NH is a 49-year-old lady who presented for assessment prior to weight reduction surgery. | ['Bariatric Surgery', 'Comorbidity', 'Female', 'Humans', 'Middle Aged', 'Obesity, Morbid', 'Sleep Apnea, Obstructive', 'Weight Loss'] | 29,328,763 | [['E02.650.500.062', 'E04.062'], ['N05.715.350.225', 'N06.850.490.687'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.699.500.500', 'G07.100.100.160.120.699.500.500'], ['C08.618.085.852.850', 'C10.886.425.800.750.85... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Next-generation sequencing for typing and detection of resistance genes: performance of a new commercial method during an outbreak of extended-spectrum-beta-lactamase-producing Escherichia coli. | Next-generation sequencing (NGS) has the potential to provide typing results and detect resistance genes in a single assay, thus guiding timely treatment decisions and allowing rapid tracking of transmission of resistant clones. We evaluated the performance of a new NGS assay (Hospital Acquired Infection BioDetection S... | ['Cluster Analysis', 'Cross-Sectional Studies', 'Disease Outbreaks', 'Drug Resistance, Bacterial', 'Escherichia coli', 'Escherichia coli Infections', 'Genes, Bacterial', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Microbial Sensitivity Tests', 'Molecular Epidemiology', 'Molecular Typing', 'Netherlands', 'Nursin... | 24,789,184 | [['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.290'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['G05.360.34... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Evaluation of a mass media campaign on smoking and pregnancy. | Two surveys were conducted among pregnant women throughout England, before (n = 625) and after (n = 607) a mass media campaign on smoking and pregnancy targeted at women aged 15-24 years, in the social grade C2DE. The majority of the post-campaign sample recalled having seen at least one of the campaign's series of pre... | ['Adolescent', 'Adult', 'England', 'Female', 'Health Education', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant, Newborn', 'Mass Media', 'Pregnancy', 'Pregnancy Complications', 'Program Evaluation', 'Smoking', 'Smoking Prevention', 'Tobacco Smoke Pollution'] | 7,804,085 | [['M01.060.057'], ['M01.060.116'], ['Z01.542.363.300'], ['I02.233.332', 'N02.421.726.407'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['L01.178.590'], ['G08.686.784.769'], ['C13.703'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['F01.145.805'],... | ['Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]',... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
An investigation of the relationship between fear of negative evaluation and bulimic psychopathology. | The current study examined fear of negative evaluation (FNE), the core fear associated with social anxiety, in the context of the dual pathway model of the etiology of bulimia nervosa. Our primary aim was to improve the understanding of the development of bulimic psychopathology. We investigated the relationships betwe... | ['Body Image', 'Bulimia Nervosa', 'Fear', 'Female', 'Humans', 'Models, Psychological', 'Phobic Disorders', 'Self Concept', 'Young Adult'] | 20,850,057 | [['F01.752.747.792.110', 'F02.463.593.112'], ['F03.400.250'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F03.080.725'], ['F01.752.747.792'], ['M01.060.116.815']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reconstructing the origin of the Lapita Cultural Complex: mtDNA analyses of East Sepik Province, PNG. | The colonization of Oceania occurred in two waves. By 32,000 BP, humans had reached New Guinea and settled all intervisible islands east to the Solomon Islands. Around 3,500 BP, a distinct intrusive group from Southeast Asia reached coastal New Guinea, integrated their components with indigenous resources, and gave ris... | ['DNA, Mitochondrial', 'Genetic Variation', 'Genetics, Population', 'Haplotypes', 'Humans', 'Mitochondria', 'Papua New Guinea', 'Phylogeny'] | 18,498,001 | [['D13.444.308.283.225'], ['G05.365'], ['H01.158.273.343.335'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['Z01.639.760.590.715'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
[Effect of difenin on taurine binding by subcellular fractions of nerve cells]. | The binding of 14C-taurine by subcellular fractions of rat brain cortex was studied in vitro. The binding was discovered to be more marked in the presence of phenytoin. The stimulant effect of phenytoin was found to be dose-dependent. The other anticonvulsant drug phenobarbital was not shown to have any noticeable effe... | ['Animals', 'Anticonvulsants', 'Brain', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Neuroblastoma', 'Neurons', 'Phenobarbital', 'Phenytoin', 'Rats', 'Stimulation, Chemical', 'Subcellular Fractions', 'Taurine'] | 6,519,259 | [['B01.050'], ['D27.505.954.427.080'], ['A08.186.211'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['C04.557.465.625.600.590.650.550', 'C04.557.470.670.590.650.550', 'C04.557.580.625.600.590.650.550'], ['A08.675', 'A11.671'], ['D03.383.742.698.253.650'], ['D03.383.129.308.432.555.730'], ['B01.050.150.900.649.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicted Mercury Soil Concentrations from a Kriging Approach for Improved Human Health Risk Assessment. | Health-risks from contaminated soils are assessed all over the world. An aspect that many risk assessments share is the heterogeneity in the distribution of contaminants. In a preceding study, we assessed potential health-risks for mothers and children living on mercury-contaminated soils in Switzerland using human bio... | ['Adult', 'Child', 'Environmental Monitoring', 'Environmental Pollution', 'Female', 'Housing', 'Humans', 'Mercury', 'Mothers', 'Risk Assessment', 'Soil', 'Soil Pollutants', 'Spatial Analysis', 'Switzerland'] | 29,941,794 | [['M01.060.116'], ['M01.060.406'], ['N06.850.460.350.080', 'N06.850.780.375'], ['N06.850.460'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['F01.829.263.500.320.200', 'I01.880.8... | ['Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Process... | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Intraoperative diagnosis in vascular surgery (author's transl)]. | The different methods of intraoperative diagnosis in vascular reconstructive surgery are described. Intraoperative angiography is of importance in the morphological assessment of reconstructive procedures, whilst functional assessment is based on pressure difference and basic and peak flow determination. The peripheral... | ['Angiography', 'Blood Flow Velocity', 'Blood Pressure Determination', 'Endarterectomy', 'False Positive Reactions', 'Humans', 'Manometry', 'Methods', 'Preoperative Care', 'Vascular Diseases'] | 442,677 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuroprotection against CCl4 | Owing to its lipophilic property, carbon tetrachloride (CCl4) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl4. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl4 and CCl4 + crocin. CCl4 administration dec... | ['Animals', 'Brain', 'Brain Injuries', 'Carbon Tetrachloride', 'Carotenoids', 'Male', 'Neuroprotective Agents', 'Rats', 'Rats, Wistar', 'Reference Standards'] | 30,273,072 | [['B01.050'], ['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['D02.455.526.439.150'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['D27.505.696.706.548', 'D27.505.954.427.575'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat. | Sixteen inbred rat strains were examined for susceptibility and resistance to group A streptococcal cell wall-induced polyarthritis. The findings indicated that 2 or more genetic loci, as well as sex-related factors, played a major role in determining susceptibility to arthritis in this model. Breeding studies demonstr... | ['Animals', 'Arthritis, Infectious', 'Cell Wall', 'Disease Models, Animal', 'Disease Susceptibility', 'Radiography', 'Rats', 'Rats, Inbred Strains', 'Sex Factors', 'Streptococcal Infections'] | 7,126,290 | [['B01.050'], ['C01.100', 'C05.550.114.099'], ['A11.284.183'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.687', 'G07.100.250'], ['E01.370.350.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['N05.715.350.675', 'N06.850.490... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Location of primary somatosensory area in cerebral arteriovenous malformation involving sensorimotor area]. | The purpose of this study was to investigate the cortical reorganization associated with congenital brain lesion such as intracerebral arteriovenous malformation (AVM). Dipole source localization of somatosensory evoked potential (SEP) was performed in five patients with AVM encompassing sensorimotor cortex. Dipole tra... | ['Adolescent', 'Adult', 'Brain Mapping', 'Evoked Potentials, Somatosensory', 'Female', 'Humans', 'Intracranial Arteriovenous Malformations', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Somatosensory Cortex'] | 10,363,268 | [['M01.060.057'], ['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.520', 'C10.500.190.500', 'C14.240.850.750.295', 'C14.240.850.875.500', 'C14.907.150.295', 'C14.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation]. | OBJECTIVE: To investigate the association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).METHODS: Thirty patients with hematological malignancies who underwent allo-HSCT were classified as... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Female', 'Graft vs Host Disease', 'Hematologic Neoplasms', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Male', 'Middle Aged', 'Recurrence', 'T-Lymphocytes, Regulatory', 'Transplantation, Homologous', 'Young Adult'] | 23,978,019 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['C20.452'], ['C04.588.448', 'C15.378.400'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.291.937'], ['A11.118.637.555.567.550.500.700', 'A... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation. | Mycobacterium avium causes disseminated infection in immunosuppressed individuals and lung infection in patients with chronic lung diseases. M. avium forms biofilm in the environment and possibly in human airways. Antibiotics with activity against the bacterium could inhibit biofilm formation. Clarithromycin inhibits b... | ['Acquired Immunodeficiency Syndrome', 'Anti-Bacterial Agents', 'Aza Compounds', 'Azithromycin', 'Biofilms', 'Clarithromycin', 'Fluoroquinolones', 'Humans', 'Microbial Sensitivity Tests', 'Microscopy, Electron, Scanning', 'Moxifloxacin', 'Mycobacterium avium Complex', 'Mycobacterium avium-intracellulare Infection', 'Qu... | 15,561,879 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['D27.505.954.122.085'], ['D02.145'], ['D02.540.576.500.992.050'], ['A20.593', 'G06.120'], ['D02.540.576.500.992.100'], ['D03.633.100.810.835.322'], ['B... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
H+/K(+)-ATPase contents of human, rabbit, hog and rat gastric mucosa. | A monoclonal antibody (mAb 95-111) was used to titrate the amounts of H+/K(+)-ATPase in subcellular fractions of the fundus of rats, pigs, rabbits and humans. All four had similar amounts of H+/K(+)-ATPase: 2.1 +/- 0.5 (human), 1.9 +/- 0.4 (rabbit), 4.4 +/- 0.5 (rat) and 4.2 +/- 0.8 (hog) mg ATPase/g wet tissue. The an... | ['Adenosine Triphosphatases', 'Animals', 'Antibodies, Monoclonal', 'Blotting, Western', 'Gastric Mucosa', 'H(+)-K(+)-Exchanging ATPase', 'Humans', 'Immunoassay', 'Kinetics', 'Rabbits', 'Rats', 'Swine'] | 2,159,803 | [['D08.811.277.040.025'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D08.811.277.040.025.314.625', 'D12.776.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation. | Histones are the building units of nucleosomes and play essential roles in DNA replication, repair and transcription. A comprehensive analysis of histone genes revealed that the Plasmodium falciparum genome encodes a canonical form of each core histone and four histone variants H2A.Z, H3.3, centromere-specific H3 (CenH... | ['Acetylation', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blotting, Western', 'DNA Primers', 'Histones', 'Mass Spectrometry', 'Molecular Sequence Data', 'Plasmodium falciparum', 'Recombinant Proteins', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Homology, Amino Acid'] | 16,410,041 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D13.695.578.424.450.275', 'D27.720.470.530.60... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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