Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. | Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21WAF1/CIP1 expression has been investi... | ['Adenocarcinoma', 'Biomarkers, Tumor', 'Colorectal Neoplasms', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclins', 'Female', 'Follow-Up Studies', 'Genes, p53', 'Humans', 'Immunoenzyme Techniques', 'Intestinal Mucosa', 'Male', 'Mutation', 'Neoplasm Proteins', 'Neoplasm Staging', 'Proto-Oncogene Proteins c-bcl-2', 'Surv... | 10,398,083 | [['C04.557.470.200.025'], ['D23.101.140'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Management of obesity: a challenge for medical training and practice. | Health-care providers are in a unique position to encourage people to make healthy lifestyle choices. However, lifestyle modification counseling is a complex task, made even more so by the cultural and socioeconomic diversity of patient populations. The objective of this study is to evaluate the prevalence and predicto... | ['Adult', 'Aged', 'Cardiovascular Diseases', 'Counseling', 'Diabetes Mellitus', 'Education, Medical', 'Educational Status', 'Employment', 'Female', 'Humans', 'Income', 'Life Style', 'Male', 'Marital Status', 'Middle Aged', 'Obesity', 'Risk Factors', 'Sex Characteristics'] | 19,107,125 | [['M01.060.116'], ['M01.060.116.100'], ['C14'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['C18.452.394.750', 'C19.246'], ['I02.358.399'], ['N01.824.196'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['F01.829.458'], ['F01.829.263.315.500', 'I01.240.361... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Purification and characterization of a novel peptide with antifungal activity from Bothrops jararaca venom. | Different peptides have been isolated from a wide range of animal species. It is has become increasingly clear that due to the development of antibiotic-resistant microbes, antibacterial and antifungal peptides have attracted the attention in recent years, in order to find new therapeutic agents. In this work, a novel ... | ['Animals', 'Antifungal Agents', 'Bothrops', 'Crotalid Venoms', 'Fluorescent Dyes', 'Fungi', 'Glucose', 'Organic Chemicals', 'Peptides'] | 15,904,677 | [['B01.050'], ['D27.505.954.122.136'], ['B01.050.150.900.833.672.125.937.240.375'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.300'], ['D09.947.875.359.448'], ['D02'], ['D12.644']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temperature acclimation and oxygen binding properties of blood of the European eel, Anguilla anguilla. | Temperature acclimation of the European eel, Anguilla anguilla, resulted in red cell GTP/Hb molar ratios of 1.20, 1.77 and 0.80 at 2, 17 and 29 degrees C, respectively. A small increase in blood oxygen capacity was present in 29 degrees C acclimated eels. The CO2 Bohr effect and the shape of the oxygen binding curve (n... | ['Acclimatization', 'Anguilla', 'Animals', 'Carbon Dioxide', 'Guanosine Triphosphate', 'Hemoglobins', 'Hydrogen-Ion Concentration', 'Kinetics', 'Oxygen', 'Species Specificity', 'Temperature'] | 2,859,959 | [['G07.025.133', 'G16.012.500.133'], ['B01.050.150.900.493.338.282'], ['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['D12.776.124.400', 'D12.776.422.316.762'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D01.268.185.550'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Randomised double-blind cross-over trial of potassium on blood-pressure in normal subjects. | A randomised double-blind cross-over study of increased oral potassium 64 mmol a day versus placebo was conducted in 20 young healthy males on normal sodium unrestricted diet. A significantly greater proportion had lower systolic and diastolic blood-pressures on potassium than on placebo. The mean diastolic pressure wa... | ['Administration, Oral', 'Adult', 'Blood Pressure', 'Clinical Trials as Topic', 'Diastole', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Humans', 'Male', 'Potassium', 'Random Allocation', 'Sodium'] | 6,128,451 | [['E02.319.267.100'], ['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A retrospective clinicopathologic study of 212 dogs with cutaneous hemangiomas and hemangiosarcomas. | The relationship between skin pigmentation and piliation and the development of hemangiomas and hemangiosarcomas in the dermis and subcutaneous tissue was studied in 212 dogs. These 212 dogs had a combined total of 306 tumors; 38 of these 212 dogs had two or more of the same tumor in a different location or a combinati... | ['Age Factors', 'Animals', 'Breeding', 'Dog Diseases', 'Dogs', 'Female', 'Follow-Up Studies', 'Hair', 'Hemangioma', 'Hemangiosarcoma', 'Male', 'Retrospective Studies', 'Sex Factors', 'Skin Neoplasms', 'Skin Pigmentation'] | 1,514,218 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['E05.820.150', 'G05.090'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A17.360'], ['C04.557.645.375'], ['C04.557.450.795.390', 'C04.557.645.390'], ['E05.318.3... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Stroke and intracranial venous thrombosis during pregnancy and puerperium. | OBJECTIVES: To determine nationally representative estimates of the incidence of stroke and intracranial venous thrombosis during pregnancy and the puerperium, and to identify potential risk factors for these conditions.METHODS: National Hospital Discharge Survey data were analyzed for the period 1979 to 1991. National... | ['Adolescent', 'Adult', 'Cerebrovascular Disorders', 'Female', 'Humans', 'Hypertension', 'Incidence', 'Intracranial Embolism and Thrombosis', 'Multivariate Analysis', 'Postpartum Period', 'Pregnancy', 'Pregnancy Complications, Hematologic', 'Risk Factors', 'Treatment Outcome', 'United States', 'Venous Thrombosis'] | 9,855,513 | [['M01.060.057'], ['M01.060.116'], ['C10.228.140.300', 'C14.907.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C10.228.140.300.525', 'C14.907.253.566', 'C14.907.355.590.213'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Recent progress and perspectives in the field of fibrinolysis]. | Employing newly developed imaging techniques, the spatio-temporal regulatory mechanism of fibrinolysis by platelets and vascular endothelial cells has been clarified. Upon activation, platelets release polyphosphate and inhibitors of fibrinolysis, and modify fibrin fibers which are relatively resistant to fibrinolysis.... | ['Antifibrinolytic Agents', 'Blood Platelets', 'Drug Design', 'Endothelial Cells', 'Fibrinolysis', 'Humans', 'Inflammation'] | 27,076,246 | [['D27.505.519.421.500', 'D27.505.954.502.270.463.091'], ['A11.118.188', 'A15.145.229.188'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['A11.436.275'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Complications of laparoscopic procedures of inguinal hernias, diagnosed on colonoscopy]. | AIM OF THE STUDY: The aim was to assess significance of colonoscopy in detection of inguinal hernias - dislocation of the mesh into the lumen of the large intestine, following inguinal hernia laparoscopic procedures (TAPP).MATERIAL, METHODOLOGY AND RESULTS: From 01-01-2004 to 31-12-2006, the authors performed 3 colonos... | ['Aged', 'Colonoscopy', 'Device Removal', 'Female', 'Hernia, Inguinal', 'Humans', 'Laparoscopy', 'Male', 'Postoperative Complications', 'Reoperation', 'Surgical Mesh'] | 17,969,978 | [['M01.060.116.100'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['E04.199'], ['C23.300.707.374.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C23.550.767'], ['E04.690'], ['E07.858.708']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
NYHA Class II subgrouping: correlation with left ventricular dysfunction questionnaire (LVD-36) and ejection fraction. | AIM: NYHA classification divides into four classes. Although subjective and lacking of standardization, NYHA class II is in clinical practice often further subgrouped in IIA and IIB, where IIA class can be defined as dyspnea after running or climbing ? 2 ramps of stairs, and IIB class as dyspnea after fast walking or c... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Female', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Stroke Volume', 'Surveys and Questionnaires', 'Terminology as Topic', 'Ultrasonography', 'Ventricular Dysfunction, Left'] | 20,938,411 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.370.380.150.700', 'G09.330.380.124.882'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['L01.559.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Antidepressant administration has a differential effect on rat brain alpha 2-adrenoceptor sensitivity to agonists and antagonists. | The aim of this study was to characterize the action of antidepressants on rat brain alpha 2-adrenoceptor function by examining their effect on the yohimbine-sensitive component of the cAMP response to adrenoceptor agonists. Using a prelabeling technique for measuring cAMP accumulation, it was found that chronic (2 wee... | ['Adrenergic alpha-Agonists', 'Adrenergic alpha-Antagonists', 'Animals', 'Antidepressive Agents', 'Brain Chemistry', 'Cyclic AMP', 'Male', 'Norepinephrine', 'Rats', 'Rats, Inbred Strains'] | 2,880,736 | [['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['B01.050'], ['D27.505.954.427.700.122'], ['G02.111.150', 'G03.185'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D02.033.100.291.502',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Foreign elites from the Oxus civilization? A craniometric study of anomalous burials from Bronze Age Tepe Hissar. | Discovery of a small number of individuals in the Period III necropolis at the large northern Iranian Bronze Age site of Tepe Hissar directly associated with a complex of imported artifacts raises the question of whether these individuals represent elites who had access to these exotic commodities, or an imposed foreig... | ['Adult', 'Anthropology, Physical', 'Anthropometry', 'Emigration and Immigration', 'Face', 'Female', 'Fossils', 'Humans', 'Iran', 'Male', 'Skull', 'Social Class'] | 10,564,573 | [['M01.060.116'], ['I01.076.368'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['A01.456.505'], ['I01.076.368.584.311'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['A02.835.232.781'], ['I01.880.853.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. | There is accumulating evidence that G protein-coupled receptor signaling is regulated by localization in lipid raft microdomains. In this report, we determined that the D1 dopamine receptor (D1R) is localized in caveolae, a subset of lipid rafts, by sucrose gradient fractionation and confocal microscopy. Through coimmu... | ['Amino Acid Motifs', 'Animals', 'Brain', 'COS Cells', 'Caveolae', 'Caveolin 1', 'Cell Membrane', 'Chlorocebus aethiops', 'Cholesterol', 'Endocytosis', 'Humans', 'Mutation', 'Rats', 'Receptors, Dopamine D1', 'Signal Transduction'] | 17,699,686 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['A08.186.211'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.284.149.165.175.160', 'A11.284.149.165.570.160', 'A11.284.430.214.190.875.190.880.180.160'], ['D12.644.360.024.264', 'D12.776.157.057.010', 'D12.776.476.024.280', 'D12.776.543... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracranial intrasellar kissing carotid arteries: case report. | Intracranial "kissing" carotid arteries are a rare variant of the carotid arteries, where both internal carotid arteries deviate medially and touch each other near the midline within the sphenoid sinus or the sphenoid bone, including the sella. This anomaly is particularly important since it may cause or mimic pituitar... | ['Carotid Artery Diseases', 'Carotid Artery, Internal', 'Female', 'Headache', 'Humans', 'Middle Aged', 'Neurosurgical Procedures', 'Radiography', 'Sphenoid Bone', 'Sphenoid Sinus'] | 17,607,445 | [['C10.228.140.300.200', 'C14.907.253.123'], ['A07.015.114.186.200.230'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.525'], ['E01.370.350.700'], ['A02.835.232.781.802'], ['A04.531.621.827']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
EGF receptor as a therapeutic target: patient selection and mechanisms of resistance to receptor-targeted drugs. | Emerging results from clinical trials of epidermal growth factor receptor (EGFR) inhibitors indicate good tolerability and at best modest to no clinical activity in a variety of human carcinomas. The lack of molecular evidence to suggest a pathogenic role for the EGFR in most common solid tumors is not inconsistent wit... | ['Animals', 'Antibodies, Monoclonal', 'Antineoplastic Agents', 'Clinical Trials as Topic', 'Drug Resistance, Neoplasm', 'Enzyme Inhibitors', 'ErbB Receptors', 'Humans', 'Neoplasms', 'Patient Selection'] | 14,645,415 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D27.505.954.248'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['G07.690.773.984.395'], ['D27.505.519.389'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of serum granulocyte colony stimulating factor levels in infants of preeclamptic mothers. | In this study we aimed to evaluate the relationship between serum granulocyte colony stimulating factor (G-CSF) levels and absolute neutrophil counts (ANC) in infants of preeclamptic mothers. The study group consisted of 31 infants of preeclamptic mothers while the control group consisted of 24 gestational age-adjusted... | ['Enzyme-Linked Immunosorbent Assay', 'Female', 'Granulocyte Colony-Stimulating Factor', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Infant, Newborn', 'Infant, Very Low Birth Weight', 'Male', 'Neutropenia', 'Pre-Eclampsia', 'Pregnancy'] | 17,479,645 | [['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.644.276.374.410.240.350', 'D12.776.395.240.200', 'D12.776.467.374.410.240.350', 'D23.529.374.410.240.350'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between lactate accumulation, LDH activity, LDH isozyme and fibre type distribution in human skeletal muscle. | Lactate concentration, total LDH activity and muscle-specific LDH isozymes were determined in pools of the two main types of human skeletal muscle fibres. Analyses were made from biopsy specimens obtained after intense dynamic exercise lasting approximately 30 s. Lactate concentration, total LDH activity and muscle-spe... | ['Adult', 'Humans', 'Isoenzymes', 'L-Lactate Dehydrogenase', 'Lactates', 'Male', 'Muscles', 'Physical Exertion'] | 665,258 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D02.241.511.459'], ['A02.633', 'A10.690'], ['G11.427.683']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel ex vivo murine retina angiogenesis (EMRA) assay. | Pathological retinal angiogenesis results from the imbalance of pro-angiogenic and anti-angiogenic factors. In particular, vascular endothelial growth factor (VEGF) plays a pivotal role in retinal neovascularization and various therapeutic VEGF blockers have evolved over time. Nevertheless, new retinal angiogenesis mod... | ['Angiogenesis Inhibitors', 'Animals', 'Antibodies, Monoclonal, Humanized', 'Antibodies, Neutralizing', 'Bevacizumab', 'Biological Assay', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Endothelium, Vascular', 'Fibrin', 'Mice', 'Mice, Inbred C57BL', 'Organ Culture Techniques', 'Ranibizumab', 'Recombinan... | 23,631,846 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D12.776.124.486.485.114... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Deficiency of C2 component in a 9-year old girl]. | The authors describe a 9 year-old girl with homozygous deficiency of C2 component, causing null activity of the classical pathway of complement. The girl suffered from several recurrent infections since birth, later developed signs of the Henoch-Sch?nlein disease. At the age of 1 1/2 years she was hospitalized due-to b... | ['Child', 'Complement C2', 'Female', 'Humans', 'Immune System Diseases', 'Infections', 'Meningitis, Bacterial', 'Recurrence'] | 9,289,715 | [['M01.060.406'], ['D12.776.124.486.274.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20'], ['C01'], ['C01.150.252.223.500', 'C01.207.180.500', 'C10.228.228.180.500', 'C10.228.614.280'], ['C23.550.291.937']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic factors that influence short-term neurodevelopmental outcome in term hypoxic-ischaemic encephalopathic neonates. | It is difficult to predict outcome in neonates that experience perinatal hypoxic ischaemia. Morbidity and mortality may be affected by genetic factors that augment inflammatory and coagulative responses. This prospective study analysed the effects of proinflammatory cytokine gene polymorphisms (tumour necrosis factor-... | ['Asphyxia Neonatorum', 'Coma', 'DNA Mutational Analysis', 'Echoencephalography', 'Factor V', 'Female', 'Genetic Association Studies', 'Humans', 'Hypoxia-Ischemia, Brain', 'Infant, Newborn', 'Interleukin-6', 'Male', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'Multiple Organ Failure', 'Muscle Hypotonia', 'Nervous S... | 22,117,975 | [['C16.614.092'], ['C10.597.606.358.800.200', 'C23.888.592.604.359.800.200'], ['E05.393.760.700.300'], ['E01.370.350.578.937.260', 'E01.370.350.700.560.260', 'E01.370.350.850.260', 'E01.370.376.537.750.260', 'E05.629.937.260'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['E05.393.385'], ['B01.050.150.90... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nerve stimulators used for peripheral nerve blocks vary in their electrical characteristics. | BACKGROUND: Nerve stimulation with a low-intensity electrical current has become a vital part of the performance of peripheral nerve blockade. The purpose of this study was to compare the accuracy and characteristics of peripheral nerve stimulators used in clinical practice in the United States.METHODS: Fifteen periphe... | ['Electric Stimulation', 'Nerve Block', 'Peripheral Nerves', 'Reproducibility of Results', 'Time Factors'] | 12,657,861 | [['E05.723.402'], ['E03.155.086.711', 'E04.525.210.550'], ['A08.800.800'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characterization of the oligomerization domain of the phosphoprotein of human parainfluenza virus type 3. | The phosphoprotein (P) of human parainfluenza virus type 3 (HPIV 3) plays a central role in the viral genome RNA transcription and replication. It acts as an essential cofactor of the RNA polymerase (L) by forming a functional L-P complex, binds to the genomic N-RNA template to recruit the L-P complex for RNA synthesis... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Dimerization', 'Gene Deletion', 'HeLa Cells', 'Humans', 'Parainfluenza Virus 3, Human', 'Phosphoproteins', 'Precipitin Tests', 'RNA, Viral', 'Software', 'Transcription, Genetic', 'Viral Proteins', 'Virus Replication'] | 12,441,081 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.206', 'G03.230'], ['G05.365.590.762.320', 'G05.558.800.320'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.480.937.600.650.700.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing]. | To investigate distributional characteristics of mutations of HPV16 upstream regulatory region (URR) and E6 and E7 oncogene in the patients with cervical cancer in Beijing and to explore the potential association between oncogenesis of cervical cancer and HPV variants in this region, cervical cancer tissue from 31 case... | ['Adult', 'Base Sequence', 'China', 'Female', 'Genetic Variation', 'Human papillomavirus 16', 'Humans', 'Mutation', 'Oncogene Proteins, Viral', 'Oncogenes', 'Papillomavirus E7 Proteins', 'Regulatory Sequences, Nucleic Acid', 'Repressor Proteins', 'Sequence Analysis, DNA', 'Uterine Cervical Neoplasms'] | 20,423,887 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['Z01.252.474.164'], ['G05.365'], ['B04.280.210.655.050.616', 'B04.613.204.655.050.616'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['D12.776.624.664.520', 'D12.776.964.700'], ['G05.360.340.024.340.375.500'], ['D12.776.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Safety of deep hypothermia in treating neonatal asphyxia. | BACKGROUND: Several studies have demonstrated the efficiency and safety of mild hypothermia (33 degrees C) used for treating moderate encephalopathy. In animal models, deep hypothermia proved to be neuroprotective.OBJECTIVES: To determine the safety of whole-body deep hypothermia between 30 and 33 degrees C in moderate... | ['Asphyxia Neonatorum', 'Body Temperature', 'Brain', 'Electroencephalography', 'Gestational Age', 'Humans', 'Hypothermia, Induced', 'Hypoxia-Ischemia, Brain', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome'] | 18,025,795 | [['C16.614.092'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750'], ['C10.228.140.300.150.716', 'C10.228.140.624.500', 'C14.907.253.092.716', 'C23.888.852.079.797.500'... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Age and interhemispheric transfer time: a failure to replicate. | In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was w... | ['Adult', 'Cerebral Cortex', 'Child', 'Child Development', 'Corpus Callosum', 'Dominance, Cerebral', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Reaction Time', 'Reference Values', 'Synaptic Transmission'] | 9,134,150 | [['M01.060.116'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['A08.186.211.200.885.800.750'], ['F02.830.297', 'G11.561.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.723.729'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['E05.978.810'], ['G02.... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sufentanil-propofol vs remifentanil-propofol during total intravenous anesthesia for neurosurgery. A multicentre study. | BACKGROUND: In a randomised, prospective multi-centre study, we compared the intraoperative and postoperative effects of two opioids: sufentanil and remifentanil, in combination with propofol in two groups of patients undergoing neurosurgery.METHODS: After Local Ethics Committee approval and informed consent obtaining,... | ['Adult', 'Aged', 'Anesthesia, Intravenous', 'Anesthetics, Combined', 'Anesthetics, Intravenous', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nervous System Diseases', 'Piperidines', 'Propofol', 'Prospective Studies', 'Remifentanil', 'Sufentanil'] | 18,414,368 | [['M01.060.116'], ['M01.060.116.100'], ['E03.155.308'], ['D27.505.696.277.100.017', 'D27.505.954.427.210.100.017'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10'], ['D03.383.621'], ['D02.455.426.559.389.657.773'], ['E05.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Amorphorization and recrystallization during plasma spraying of hydroxyapatite. | X-ray diffraction was used to characterize the dependence of mean crystallite size and crystallinity on the thickness of coatings. A fall in mean crystallite size but a rise in crystallinity with increased thickness was observed. The reason might be due to the differences in cooling rate of partially molten particles o... | ['Biocompatible Materials', 'Crystallization', 'Durapatite', 'Hot Temperature', 'Particle Size', 'Temperature', 'X-Ray Diffraction'] | 8,527,597 | [['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.196.300', 'G02.171'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', '... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Urinary exosomal microRNAs in incipient diabetic nephropathy. | MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exo... | ['Albuminuria', 'Animals', 'Cells, Cultured', 'Diabetes Mellitus, Type 1', 'Diabetic Nephropathies', 'Exosomes', 'Gene Expression', 'Glucose', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'MicroRNAs', 'Middle Aged', 'Up-Regulation'] | 24,223,694 | [['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['B01.050'], ['A11.251'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['G05.297'], ['D09.947.875.359.448']... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Egocentric or allocentric frameworks for the evaluation of other people's reachability. | The adoption of egocentric and allocentric frameworks in the perception of other people's reachability was investigated. In study 1, 24 adults (12 experienced and 12 inexperienced dealing with children) judged vertical reachability for themselves and for two children. In study 2, 37 parents judged vertical reachability... | ['Adult', 'Body Height', 'Distance Perception', 'Female', 'Humans', 'Judgment', 'Male', 'Middle Aged', 'Orientation', 'Psychomotor Performance', 'Statistics as Topic', 'Young Adult'] | 21,816,496 | [['M01.060.116'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['F02.463.593.200.390', 'F02.463.593.778.255.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['M01.060.116.630'], ['F01.058.577', 'F02.830.606'], ['F02.808', 'G11.427.700'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease. | Alzheimer's disease (AD) is a progressive amnestic disorder typified by the pathological misfolding and deposition of the microtubule-associated tau protein into neurofibrillary tangles (NFTs). While numerous post-translational modifications influence NFT formation, the molecular mechanisms responsible for tau aggregat... | ['Alzheimer Disease', 'Amino Acid Sequence', 'Cross-Linking Reagents', 'Electrophoresis, Polyacrylamide Gel', 'Light', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Nitrates', 'Oxidation-Reduction', 'Peroxynitrous Acid', 'Phosphorylation', 'Protein Processing, Post-Translational', 'Scattering, Radiation', '... | 15,683,253 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D27.720.470.410.210'], ['E05.196.401.402', 'E05.301.300.319'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['D01.248.497.158.606',... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Vitamin A consumption in pregnant and non pregnant rats, and in castrated rats receiving or not receiving estradiol or pregnenolone; relation to tocopherol and cytochrome P-450]. | Consumption of vitamin A and cytochrome P 450 by pregnant Rat is more important than in non pregnant and ovariectomised Rat. Estradiol implant in ovariectomised female has some, but slighter, influence only on retinol. These physiological situations have no action on the hepatic levels of tocopherols (total and alpha).... | ['Animals', 'Castration', 'Cytochrome P-450 Enzyme System', 'Diet', 'Drug Implants', 'Estradiol', 'Female', 'Liver', 'Pregnancy', 'Pregnancy, Animal', 'Pregnenolone', 'Rats', 'Vitamin A', 'Vitamin E'] | 115,610 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The usability of the upper eyelid crease approach for correction of medial orbital wall blowout fracture. | BACKGROUND: There are many approaches to the medial orbital wall. However, most of them have problems with limitation of exposure, scarring, and postoperative inflammatory symptoms related to the eye. The authors used an upper eyelid crease approach to overcome these problems and investigate the usefulness of this appr... | ['Adolescent', 'Adult', 'Child', 'Cohort Studies', 'Eyelids', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Internal', 'Fracture Healing', 'Humans', 'Injury Severity Score', 'Male', 'Middle Aged', 'Orbital Fractures', 'Prostheses and Implants', 'Reconstructive Surgical Procedures', 'Recovery of Function', 'Retrosp... | 23,018,700 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A01.456.505.420.504', 'A09.371.337'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.555.300.300'], ['G16.762.891.500'], ['B01.050.150.90... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Glioblastoma in children: a single-institution experience. | PURPOSE: Current treatment recommendations for pediatric glioblastoma include surgery, chemotherapy, and radiation therapy. However, even with this multispecialty approach, overall survival remains poor. To assess outcome and evaluate treatment-related prognostic factors, we retrospectively reviewed the experience at o... | ['Adolescent', 'Antineoplastic Combined Chemotherapy Protocols', 'Brain Neoplasms', 'Cancer Care Facilities', 'Child', 'Child, Preschool', 'Female', 'Glioblastoma', 'Humans', 'Male', 'Missouri', 'Outcome Assessment, Health Care', 'Radiotherapy Dosage', 'Radiotherapy, Conformal', 'Retrospective Studies', 'Survival Rate'... | 21,220,190 | [['M01.060.057'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['N02.278.421.556.070'], ['M01.060.406'], ['M01.060.406.448'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['B01.050.150.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
In vivo and in vitro metabolism of a novel â2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS/MS and NMR. | Trantinterol is a novel â(2)-adrenoceptor agonist used for the treatment of asthma. The aim of this study is to identify the metabolites of trantinterol using liquid chromatography tandem mass spectrometry (LC-MS/MS), to isolate the main metabolites, and confirm their structures by nuclear magnetic resonance (NMR). Uri... | ['Adrenergic beta-2 Receptor Agonists', 'Animals', 'Chromatography, High Pressure Liquid', 'Clenbuterol', 'Humans', 'Magnetic Resonance Spectroscopy', 'Male', 'Microsomes, Liver', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Adrenergic, beta-2', 'Tandem Mass Spectrometry'] | 23,338,754 | [['D27.505.519.625.050.100.200.200', 'D27.505.696.577.050.100.200.200'], ['B01.050'], ['E05.196.181.400.300'], ['D02.033.100.291.231', 'D02.092.063.291.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['A11.284.835.540.541'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Longitudinal study of medical students selected for admission to medical school by actuarial and committee methods. | This study evaluates a "mid period" follow-up evaluation of the outcomes of selection of medical students by customary committee review procedures versus actuarial selection. One-third of a freshman class was selected solely on the basis of a predictor index which was a previously validated, optimally weighted combinat... | ['Attitude of Health Personnel', 'Educational Measurement', 'Follow-Up Studies', 'Internship and Residency', 'Minnesota', 'Personality', 'Regression Analysis', 'School Admission Criteria', 'Schools, Medical', 'Students, Medical'] | 1,148,133 | [['F01.100.050', 'N05.300.100'], ['I02.399'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['Z01.107.567.875.350.510', 'Z01.107.567.875.510.510'], ['F01.752'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'],... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Hypnosis, placebo, and suggestion in the treatment of warts. | Two experiments assessed the effects of psychological variables on wart regression. In Experiment 1, subjects given hypnotic suggestion exhibited more wart regression than those given either a placebo treatment or no treatment. In Experiment 2, hypnotic and nonhypnotic subjects given the same suggestions were equally l... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Hypnosis', 'Imagination', 'Male', 'Middle Aged', 'Placebos', 'Sex Factors', 'Suggestion', 'Warts'] | 3,387,508 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.217', 'F04.754.424'], ['F02.463.188.634'], ['M01.060.116.630'], ['D26.660', 'E02.785'], ['N05.715.350.675', 'N06.850.490.875'], ['E02.190.525.217.771', 'F04.754.424.771'], ['C01.925.25... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation. | BACKGROUND: Bone mineral density (BMD) loss commonly occurs after hematopoietic cell transplantation (HCT). Hypothesizing that genetic variants may influence post-HCT BMD loss, we conducted a prospective study to examine the associations of single nucleotide polymorphisms (SNP) in bone metabolism pathways and acute BMD... | ['Adult', 'Aged', 'Alleles', 'Bone Density', 'DNA', 'Female', 'Genetic Variation', 'Genome, Human', 'Genotype', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Male', 'Middle Aged', 'Models, Genetic', 'Polymorphism, Single Nucleotide', 'Risk Factors'] | 22,022,476 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['G11.427.100'], ['D13.444.308'], ['G05.365'], ['G05.360.340.350'], ['G05.380'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.395.397'], ['G05.365.795.598'], ['E05.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lumbar muscle electromyographic dynamic topography during flexion-extension. | The objective of this study is to introduce dynamic topography of surface electromyography (SEMG) to visualize lumbar muscle myoelectric activity and provides a new view to analyze muscle activity in vivo. A total of 20 healthy male subjects and 15 males LBP were enrolled. An electrode-array was applied to the lumbar r... | ['Back', 'Chronic Disease', 'Electromyography', 'Humans', 'Low Back Pain', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Movement', 'Muscle Contraction', 'Muscle, Skeletal', 'Task Performance and Analysis'] | 19,540,776 | [['A01.923.176'], ['C23.550.291.500'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['G07.568', 'G11.427.410'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['F02.784.412.846', 'F02.784.692.746... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synergistic deep removal of As(III) and Cd(II) by a calcined multifunctional MgZnFe-CO3 | A high removal rate (>99.7%) of combined arsenite (As(III)) and Cd (Cd(II)) in low concentration (1000 ìg/L) from contaminated water was achieved by a calcined MgZnFe-CO3 layered double hydroxide (CMZF) adsorbent. Batch control studies and a series of spectroscopy detection technologies were employed to investigate the... | ['Adsorption', 'Arsenic', 'Cadmium', 'Chemical Precipitation', 'Hydrogen-Ion Concentration', 'Hydroxides', 'Iron', 'Kinetics', 'Magnesium', 'Models, Molecular', 'Molecular Conformation', 'Oxidation-Reduction', 'Photochemical Processes', 'Temperature', 'Zinc'] | 30,870,628 | [['G01.030', 'G02.020'], ['D01.268.513.249'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['E05.196.150', 'G02.159'], ['G02.300'], ['D01.045.250', 'D01.248.497.158.459'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['G01.374.661', 'G02.111.490'], ['D01.268.552.437', 'D01.268.557.500', 'D01... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ. | We have previously shown that high human papillomavirus (HPV) 16 load in Papanicolaou smears negative for dysplasia is strongly associated with risk for carcinoma in situ (CIS) of the cervix. Here we study the amount of HPV DNA for some of the most frequent high-risk HPV types as determinants of progression to cervical... | ['Adult', 'Carcinoma in Situ', 'Case-Control Studies', 'DNA, Viral', 'Female', 'Humans', 'Middle Aged', 'Papanicolaou Test', 'Papillomaviridae', 'Polymerase Chain Reaction', 'Risk Assessment', 'Uterine Cervical Neoplasms', 'Vaginal Smears', 'Viral Load'] | 15,386,375 | [['M01.060.116'], ['C04.557.470.200.240'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.500.384.100.422', 'E01.370.225.998.054.422', 'E04.074.422', 'E05.200.500.384.100.422', 'E05.2... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Behavioral and neurochemical studies on brain aging in galanin overexpressing mice. | To study possible involvement of galanin in brain aging quality, we have investigated behavioral, neurochemical and morphological parameters in aged mice overexpressing galanin under the platelet-derived growth factor B promoter (GalOE mice) compared to wild-type littermates (WT mice). The behavioral analysis in the fo... | ['Aging', 'Animals', 'Anxiety', 'Behavior, Animal', 'Brain', 'Depression', 'Dopamine', 'Exploratory Behavior', 'Galanin', 'Gene Expression', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Norepinephrine', 'Tritium'] | 15,944,027 | [['G07.345.124'], ['B01.050'], ['F01.470.132'], ['F01.145.113'], ['A08.186.211'], ['F01.145.126.350'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['F01.145.387', 'F01.658.370'], ['D12.644.400.250', 'D12.776.631.650.250'], ['G05.297'], ['B01.050.150.900.649.313.992.635.505.500'], ... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors associated with the development of chorioretinal atrophy around choroidal neovascularization in pathologic myopia. | PURPOSE: To examine the influencing factors on the development of chorioretinal atrophy, which is the main cause of long-term visual decrease in myopic choroidal neovascularization (CNV), in a large series of highly myopic patients.METHODS: Sixty-five patients (81 eyes) with myopic CNV were studied retrospectively. The... | ['Atrophy', 'Choroid', 'Choroidal Neovascularization', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myopia', 'Retina', 'Retrospective Studies', 'Risk Factors', 'Visual Acuity'] | 14,648,134 | [['C23.300.070'], ['A09.371.894.223'], ['C11.941.160.244', 'C23.550.589.500.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C11.744.636'], ['A09.371.729'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Use of enteric-coated mycophenolate sodium in de novo renal transplant recipients with high incidence of delayed graft function. | Patients with delayed graft function (DGF) are at risk of increased incidence for acute rejection episodes (ARE). Mycophenolate mofetil or induction therapy has produced a reduction in ARE incidence. An open, prospective, 3-month trial was performed in a group of Argentinian renal transplant recipients. We recruited 46... | ['Adult', 'Cyclosporine', 'Emulsions', 'Female', 'Graft Survival', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Living Donors', 'Male', 'Middle Aged', 'Mycophenolic Acid', 'Tablets, Enteric-Coated'] | 16,647,505 | [['M01.060.116'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D20.280.260', 'D26.255.165.260'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.898.656'], ['M01.060.116.630'], ['D02.241.081.193.678', 'D10.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Functional hybrid rubisco enzymes with plant small subunits and algal large subunits: engineered rbcS cDNA for expression in chlamydomonas. | There has been much interest in the chloroplast-encoded large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) as a target for engineering an increase in net CO(2) fixation in photosynthesis. Improvements in the enzyme would lead to an increase in the production of food, fiber, and renewable energy.... | ['Algal Proteins', 'Arabidopsis', 'Base Sequence', 'Blotting, Western', 'Chlamydomonas', 'DNA, Complementary', 'Enzyme Stability', 'Gene Expression Regulation, Enzymologic', 'Helianthus', 'Kinetics', 'Microscopy, Electron', 'Molecular Sequence Data', 'Mutation', 'Photosynthesis', 'Plant Proteins', 'Plasmids', 'Protein ... | 20,424,165 | [['D12.776.037'], ['B01.650.940.800.575.912.250.157.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.650.940.150.385'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Interrelationship among annual cycles of sex steroids, corticosterone and body condition in Nyctibatrachus humayuni. | Synergism between extrinsic and intrinsic factors is crucial for the seasonality of reproduction. Environmental factors such as photoperiod and temperature activate the hypothalamus-pituitary-gonadal axis leading to the secretion of steroid hormones that are crucial for reproduction. Sex steroids are not only essential... | ['Animals', 'Anura', 'Body Constitution', 'Corticosterone', 'Estradiol', 'Female', 'Gonadal Steroid Hormones', 'Male', 'Ovary', 'Photoperiod', 'Progesterone', 'Reproduction', 'Seasons', 'Testis', 'Testosterone'] | 29,339,182 | [['B01.050'], ['B01.050.150.900.090.180'], ['E01.370.600.115', 'G07.100'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.334.851'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['G01.910.675'], ['D04.210.500.745.745.654.82... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. | The beta-amyloid peptides derived by proteolytic cleavage from the amyloid precursor protein (APP) play a major role in the pathogenesis of Alzheimer's disease (AD) by forming aggregated, fibrillary complexes that have been shown to be neurotoxic. The beta-site APP-cleaving enzyme (BACE1) has been identified as the key... | ['Adenylyl Cyclases', 'Alzheimer Disease', 'Amyloid Precursor Protein Secretases', 'Aspartic Acid Endopeptidases', 'Brain', 'Cyclic AMP-Dependent Protein Kinases', 'Dose-Response Relationship, Drug', 'Endopeptidases', 'Humans', 'MAP Kinase Signaling System', 'Muscarinic Agonists', 'Neurons', 'Phorbol Esters', 'Protein ... | 15,211,591 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D08.811.277.656.300.032'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['A08.186.211'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['G0... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Thermography and thermoregulation of the face. | BACKGROUND: Although clinical diagnosis of thermoregulation is gaining in importance there is no consistent evidence on the value of thermography of the facial region. In particular there are no reference values established with standardised methods.METHODS: Skin temperatures were measured in the facial area at 32 fixe... | ['Adolescent', 'Adult', 'Aged', 'Body Temperature Regulation', 'Child', 'Circadian Rhythm', 'Face', 'Female', 'Humans', 'Male', 'Middle Aged', 'Skin Temperature', 'Surveys and Questionnaires', 'Thermography'] | 17,362,518 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['M01.060.406'], ['G07.180.562.190'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G07.110.753', 'G13.750.844'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A quartz crystal microbalance method for rapid detection and differentiation of shiga toxins by applying a monoalkyl globobioside as the toxin ligand. | A simple globobiosyl (Gb2) ceramide mimic carrying a monoalkyl chain (C18) was applied for a monolayer Langmuir-Blodgett (L-B) technique to detect Shiga toxins (Stxs) by a quartz crystal microbalance (QCM) method. The artificial glycolipid, synthesized from penta-O-acetyl-D-galactopyranose via a conventional glycosidat... | ['Binding, Competitive', 'Clinical Laboratory Techniques', 'Escherichia coli Infections', 'Escherichia coli O157', 'Globosides', 'Humans', 'Ligands', 'Molecular Mimicry', 'Protein Binding', 'Quartz', 'Shiga Toxin 1', 'Shiga Toxin 2', 'Shiga Toxins', 'Surface Properties', 'Weights and Measures'] | 12,005,508 | [['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E01.370.225', 'E05.200'], ['C01.150.252.400.310.330'], ['B03.440.450.425.325.300.800.250.500', 'B03.660.250.150.180.100.800.250.500'], ['D02.065.313.425', 'D09.400.410.420.525.200.425', 'D10.390.470.675.200.425', 'D10.570.877.360.612.200.425'], ['B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term ungulate exclusion reduces fungal symbiont prevalence in native grasslands. | When symbionts are inherited by offspring, they can have substantial ecological and evolutionary consequences because they occur in all host life stages. Although natural frequencies of inherited symbionts are commonly <100 %, few studies investigate the ecological drivers of variation in symbiont prevalence. In plants... | ['Animals', 'Endophytes', 'Epichloe', 'Grassland', 'Poaceae', 'Prevalence', 'Symbiosis'] | 27,113,054 | [['B01.050'], ['B05.237'], ['B01.300.107.501.310'], ['G16.500.275.157.531', 'N06.230.124.390'], ['B01.650.940.800.575.912.250.822'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['G06.550.800', 'G16.840']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Anti-Inflammatory and Cytoprotective Effect of Plant Sterol and Galactooligosaccharides-Enriched Beverages in Caco-2 Cells. | Plant sterol (PS) (1 g/100 mL) enriched milk-based fruit beverages with or without galactooligosaccharides (GOS) (1.8 g/100 mL) were used in differentiated Caco-2 cells. Their potential cytopreventive effect against oxidative stress induced by cholesterol oxidation products (COPs) and their anti-inflammatory properties... | ['Anti-Inflammatory Agents', 'Beverages', 'Caco-2 Cells', 'Cytoprotection', 'Humans', 'Interleukin-1beta', 'Oligosaccharides', 'Oxidative Stress', 'Phytosterols', 'Protective Agents', 'Transcription Factor RelA'] | 31,290,324 | [['D27.505.954.158'], ['G07.203.100', 'J02.200'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G07.690.773.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D12.776.467.374.465.010.600', 'D12.776.467.374.500.400.600', 'D23.529.374... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target. | Inappropriate upregulation of cyclooxygenase-2 (COX-2) and matrix metalloproteinases (MMPs) has been implicated in the pathogenesis of various types of cancer. In the present study, we investigated the effects of hirsutenone, a diarylheptanoid isolated from the medicinal plant Alnus hirsuta var. sibirica, on the expres... | ['Active Transport, Cell Nucleus', 'Catechols', 'Cell Line', 'Cell Movement', 'Cyclooxygenase 2', 'Diarylheptanoids', 'Dinoprostone', 'Epithelial Cells', 'Gene Expression Regulation, Enzymologic', 'Genes, Reporter', 'Humans', 'Mammary Glands, Human', 'Matrix Metalloproteinase 9', 'Membrane Proteins', 'Molecular Structu... | 16,380,122 | [['G03.143.310.100', 'G03.143.700.100'], ['D02.455.426.559.389.657.166'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['D08.811.600.720.750'], ['D02.455.326.146.485.222', 'D02.455.426.559.694'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['A11.436'], ['G05.308.320'], ['G05.360.340.024.340.435'... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Post-transcriptional regulation of expression of the Bronze2 gene of Zea mays L. | The glutathione S-transferase encoded by Bronze2 performs the last genetically defined step in maize anthocyanin biosynthesis, being required for pigment sequestration into vacuoles. The Bz2 primary transcript contains a single intron; in maize leaves both spliced and unspliced Bz2 transcripts are usually present and a... | ["5' Untranslated Regions", 'Anthocyanins', 'Blotting, Western', 'Cadmium', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Plant', 'Genotype', 'Glutathione Transferase', 'Plant Proteins', 'Plant Roots', 'Plants, Genetically Modified', 'Promoter Regions, Genetic', 'RNA Processing, Post-Transcrip... | 14,756,308 | [['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['D03.383.663.283.266.450.087', 'D03.633.100.150.266.450.087', 'D09.408.084', 'D23.767.124'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reaction to the Diagnosis of Cancer Questionnaire: development and psychometric evaluation. | The purpose of this study was to develop a scale to assess the initial reactions of individuals to the diagnosis of cancer. Content validity was built into the Reaction to the Diagnosis of Cancer Questionnaire (RDCQ) through responses supplied by 340 ambulatory cancer patients to the question, "What do you remember of ... | ['Adaptation, Psychological', 'Adult', 'Aged', 'Aged, 80 and over', 'Attitude to Health', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Psychological Tests', 'Psychometrics', 'Stress, Psychological', 'Surveys and Questionnaires'] | 2,587,293 | [['F01.058'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.150', 'N05.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['F04.711'], ['F04.711.780'], ['F01.145.126.990', 'F02.830.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Free full thickness mucosal grafts in the mouth. | Examples of full thickness mucosal grafts used in sulcoplasty and the closure of defects in the tongue and cheek following tumour ablation are shown and the techniques in their use are demonstrated. The problems and advantages in this are considered. | ['Aged', 'Carcinoma, Squamous Cell', 'Cheek', 'Denture, Complete, Lower', 'Female', 'Gingival Hyperplasia', 'Humans', 'Male', 'Middle Aged', 'Mouth Mucosa', 'Mouth Neoplasms', 'Tongue Neoplasms', 'Transplantation, Autologous'] | 1,068,666 | [['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A01.456.505.173', 'A14.194'], ['E06.780.346.760.775.379', 'E07.695.190.200.205.210'], ['C07.465.714.258.428.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A10.615.550.599', 'A14.549.512'], ['C04.588.443.591', 'C07.46... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Baseline data of reproductive system in the JPHC study. Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases. | Hormonal status in the body is closely related to the occurrence of estrogen-related cancers. Baseline survey data about the female reproductive system in JPHC study showed different gynecological and gestational profiles in each study area. Late menarche (15-16 y/o) was characteristic in the rural areas. Earlier gesta... | ['Adult', 'Age Distribution', 'Aged', 'Breast Feeding', 'Female', 'Genital Neoplasms, Female', 'Health Status', 'Health Surveys', 'Hormone Replacement Therapy', 'Humans', 'Japan', 'Mass Screening', 'Menarche', 'Menopause', 'Menstrual Cycle', 'Middle Aged', 'Neoplasms', 'Population Surveillance', 'Pregnancy', 'Prospecti... | 11,763,141 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['C04.588.945.418', 'C13.351.937.418'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E05.318.308.980.438', 'N05.715.360.300.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Comparison between solid phase microextraction (SPME) and hollow fiber liquid phase microextraction (HFLPME) for determination of extractables from post-consumer recycled PET into food simulants. | Hollow fiber liquid phase microextraction (HFLPME) and solid phase microextraction (SPME) methods for pre-concentration of contaminants (toluene, benzophenone, tetracosane and chloroform) in food simulants were investigated. For HFLPME 1-heptanol, 2-octanone and dibutyl-ether were studied as extracting solvents. Analys... | ['Acetic Acid', 'Alkanes', 'Benzophenones', 'Chloroform', 'Ethanol', 'Food Contamination', 'Food Packaging', 'Liquid Phase Microextraction', 'Polyethylene Terephthalates', 'Recycling', 'Solid Phase Microextraction', 'Toluene'] | 24,913,857 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['D02.455.326.146'], ['D02.455.426.559.389.134', 'D02.522.223'], ['D02.455.526.439.224', 'D02.455.526.913.810'], ['D02.033.375'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['J01.576.423.200.375', 'J01.576.423.850.600', 'J01.576.761.400'],... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network. | PURPOSE: Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells... | ['Animals', 'Blotting, Western', 'Cells, Cultured', 'Down-Regulation', 'GTP Phosphohydrolases', 'Gene Expression Regulation', 'Gene Silencing', 'Immunohistochemistry', 'Isoenzymes', 'Mitochondria', 'Mitochondrial Diseases', 'Mitochondrial Proteins', 'RNA, Messenger', 'RNA, Small Interfering', 'Rats', 'Rats, Wistar', 'R... | 16,249,510 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D08.811.277.040.330'], ['G05.308'], ['G05.308.203.374'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Lifetime weight gain linked to oesophageal and stomach cancers. | People who are overweight in early adulthood and become obese in later life are three times more likely to develop cancer of the oesophagus or upper stomach, new study results suggest. | ['Esophageal Neoplasms', 'Humans', 'Stomach Neoplasms', 'Weight Gain'] | 28,247,779 | [['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['C23.888.144.243.926', 'G07.345.249.314.120.200.926']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental uveitis can be maintained in rabbits for a period of six weeks after a safe sensitization method. | PURPOSE: New treatments against long-lasting uveitis need to be tested. Our aim was to develop a six-week model of uveitis in rabbits.METHODS: Rabbits were presensitized with an s.c. injection of Mycobacterium tuberculosis H37RA emulsified with TiterMax Gold adjuvant. Uveitis was induced at day 28 and 50, by intravitre... | ['Adjuvants, Immunologic', 'Animals', 'Antigens, Bacterial', 'Aqueous Humor', 'Disease Models, Animal', 'Disease Progression', 'Female', 'Immunization', 'Injections, Subcutaneous', 'Intravitreal Injections', 'Rabbits', 'Time Factors', 'Uveitis'] | 23,294,112 | [['D27.505.696.477.067'], ['B01.050'], ['D23.050.161'], ['A09.371.060.067.070', 'A12.207.270.040'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['E02.319.267.530.620'], ['E02.319.267.530.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
First description of the male of Yaobinthrips yangtzei (Thysanoptera: Thripidae). | The monobasic Thripinae genus Yaobinthrips has been known only from females, and the objective here is to provide a description of the male. A member of the Frankliniella genus-group, the type species, yangtzei Zhang et al. (2010) was described from specimens taken in Sichuan Province of Southwestern China from the flo... | ['Animal Structures', 'Animals', 'Body Size', 'China', 'Fabaceae', 'Female', 'Flowers', 'Male', 'Organ Size', 'Thysanoptera'] | 27,395,534 | [['A13'], ['B01.050'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['Z01.252.474.164'], ['B01.650.940.800.575.912.250.401'], ['A18.024.249.500'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['B01.050.500.131.617.800']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Localization of acetylcholinesterase activity and mRNA in the rabbit embryo between 10 and 15 days. | Histoenzymatic methods and in situ hybridization were used to follow AChE expression in rabbit embryos from 10 to 15 days. Transcripts of AChE are detected at the same developmental stages in all structures where enzymatic activity is found, except in neuronal extension and the ventral part of mesonephros. AChE and BCh... | ['Acetylcholinesterase', 'Animals', 'Butyrylcholinesterase', 'Embryo, Mammalian', 'Embryonic and Fetal Development', 'Gestational Age', 'In Situ Hybridization', 'RNA, Messenger', 'Rabbits'] | 8,186,691 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['D08.811.277.352.100.170.250'], ['A16.254'], ['G07.345.500.325', 'G08.686.784.170'], ['G07.345.500.325.235.968', 'G08.686.320'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D13.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stimulation of synovial fibroblasts by calcium oxalate and monosodium urate monohydrate. A mechanism of connective tissue degradation in oxalosis and gout. | The responses of cultured rabbit synovial fibroblasts to amorphous and microcrystalline calcium oxalate were compared with responses to MSUM. Like urate crystals, crystalline calcium oxalate (but not amorphous oxalate) caused marked stimulation of secretion of latent collagenase and PGE2 after 3 days of culture without... | ['Animals', 'Calcium Oxalate', 'Connective Tissue Diseases', 'Crystallization', 'Dinoprostone', 'Dose-Response Relationship, Drug', 'Fibroblasts', 'Gout', 'Hemolysis', 'L-Lactate Dehydrogenase', 'Microbial Collagenase', 'Prostaglandins E', 'Rabbits', 'Synovial Fluid', 'Uric Acid'] | 6,292,314 | [['B01.050'], ['D02.241.081.337.593.750.500'], ['C17.300'], ['E05.196.300', 'G02.171'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.329.228'], ['C05.550.114.423', 'C05.550.354.500', 'C05.799.414', 'C16.320.565.798.368', 'C18.452.648.798.368'], ['C23.550.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Swimmer's view: a diagnostic adjunct for oesophageal foreign bodies. | We describe the use of a common radiographic view of the lower cervical skeleton, 'Swimmer's View', to aid the diagnosis of foreign bodies in the upper oesophagus, which may be obscured by the clavicles. We further recommend this view when there is uncertainty over the nature of an impacted food bolus in this location,... | ['Adult', 'Esophagus', 'Foreign Bodies', 'Humans', 'Male', 'Radiography'] | 12,363,193 | [['M01.060.116'], ['A03.556.875.500'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate. | Alagille syndrome (AGS) is caused by heterozygous mutations in JAG1, and mutations have been previously reported in about 70% of patients who meet clinical diagnostic criteria. We studied a cohort of 247 clinically well-defined patients, and using an aggressive and sequential screening approach we identified JAG1 mutat... | ['Alagille Syndrome', 'Calcium-Binding Proteins', 'Cohort Studies', 'DNA Mutational Analysis', 'Genetic Testing', 'Humans', 'In Situ Hybridization, Fluorescence', 'Intercellular Signaling Peptides and Proteins', 'Jagged-1 Protein', 'Membrane Proteins', 'Mutation', 'Polymorphism, Genetic', 'Serrate-Jagged Proteins'] | 16,575,836 | [['C06.130.120.135.250.125', 'C06.552.150.125', 'C14.240.400.044', 'C16.131.077.065', 'C16.131.240.400.044', 'C16.320.051'], ['D12.776.157.125'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.393.760.700.300'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', '... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Henna (Lawsonia inermis Linn.) induced haemolytic anaemia in siblings. | Henna is a traditional cosmetic agent and is used worldwide. It is used worldwide not only as a cosmetic agent to stain the hair, skin and nails but also is applied to the body on lesions in the treatment of seborrheic dermatitis or fungal infections. Different pathologies have been described as caused by henna. The ai... | ['Administration, Topical', 'Anemia, Hemolytic', 'Child', 'Dermatologic Agents', 'Female', 'Glucosephosphate Dehydrogenase Deficiency', 'Humans', 'Ichthyosis Vulgaris', 'Male', 'Naphthoquinones', 'Pedigree', 'Siblings'] | 15,206,514 | [['E02.319.267.120'], ['C15.378.071.141'], ['M01.060.406'], ['D27.505.954.444'], ['C15.378.071.141.150.480', 'C16.320.070.480', 'C16.320.565.202.402', 'C18.452.648.202.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.131.831.512.410', 'C16.320.850.405', 'C17.800.428.333.410', 'C17.800.804.512.410', 'C17.80... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Determination of sialic acids in infant formula by chromatographic methods: a comparison of high-performance anion-exchange chromatography with pulsed amperometric detection and ultra-high-performance liquid chromatography methods. | Sialic acid determination in an infant formula presents many challenges, including efficient sialic acid release from glycoconjugates, effective sample preparation, and rugged chromatography. This work compares 2 chromatographic assays developed for determination of sialic acids in infant formula. Prior to chromatograp... | ['Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Humans', 'Infant', 'Infant Formula', 'N-Acetylneuraminic Acid', 'Neuraminic Acids', 'Sensitivity and Specificity'] | 22,365,198 | [['E05.196.181.400.300'], ['E05.196.181.400.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G07.203.100.712.249', 'G07.203.300.525.350.500', 'G07.203.300.525.500.500', 'J02.200.712.249', 'J02.500.525.350.500', 'J02.500.525.500.500'], ['D02.241.081.844.562.668.050', 'D02.241.511.902.562.668.05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK). | The PAK Ser/Thr kinases are important downstream effectors of the Rho family GTPases Cdc42 and Rac, partly mediating the role of these G proteins in cell proliferation and cytoskeletal rearrangements. As well as small G proteins, PAK interacts with the Cdc42/Rac exchange factor beta-PIX via the PIX SH3 domain and a non... | ['Amino Acids', 'Animals', 'Cell Cycle Proteins', 'Guanine Nucleotide Exchange Factors', 'Guanosine Diphosphate', 'Guanosine Triphosphate', 'Humans', 'Nuclear Magnetic Resonance, Biomolecular', 'Peptides', 'Protein Binding', 'Protein Structure, Quaternary', 'Protein-Serine-Threonine Kinases', 'Rho Guanine Nucleotide Ex... | 16,101,281 | [['D12.125'], ['B01.050'], ['D12.776.167'], ['D12.644.360.325.300', 'D12.776.476.325.300'], ['D03.633.100.759.646.454.340', 'D13.695.667.454.340', 'D13.695.827.426.340'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519.550... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fetal heart rate transmission with the facsimile telecopier in rural areas. | Over a 30-month period, 24 portable facsimile telecopiers were placed in rural hospitals with delivery services, allowing 24-hour direct transmission of fetal heart rate tracings for consultation. An analysis of the first 209 intrapartum fetal heart rate strips is presented. Variable decelerations were the most frequen... | ['Electrocardiography', 'Female', 'Heart Rate, Fetal', 'Hospital Communication Systems', 'Hospitals', 'Hospitals, Rural', 'Humans', 'Pregnancy', 'Referral and Consultation', 'Telecommunications', 'Utah'] | 2,729,378 | [['E01.370.370.380.240', 'E01.370.405.240'], ['G09.330.380.500.430'], ['N02.278.216.500.937', 'N04.452.442.452.322'], ['N02.278.421'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['N04.452.758.849'], ['L01.178.847'], ['Z01.107.567.875.760.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Linking attentional control and PTSD symptom severity: the role of rumination. | Although deficits in attentional control have been linked to posttraumatic stress disorder (PTSD), the mechanism that may account for this association has not been fully elucidated. The present study examined rumination as a mediator of the relationship between attentional control and PTSD symptoms. Veterans with PTSD ... | ['Adult', 'Attention', 'Female', 'Humans', 'Male', 'Rumination, Cognitive', 'Stress Disorders, Post-Traumatic', 'Survivors', 'Trauma Severity Indices', 'Veterans'] | 28,632,107 | [['M01.060.116'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.878'], ['F03.950.750.500'], ['M01.860'], ['E05.318.308.940.968.875', 'E05.944', 'N04.452.859.564.800', 'N05.715.360.300.715.500.800', 'N06.850.520.308.940.968.875'], ['M01.930']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reasons for poor adherence to antiretroviral therapy postnatally in HIV-1 infected women treated for their own health: experiences from the Mitra Plus study in Tanzania. | BACKGROUND: In a study of prevention of mother-to-child transmission of HIV (PMTCT) by triple antiretroviral therapy (ART) in Dar es Salaam, Tanzania (the Mitra Plus study), retrospective viral load testing revealed a high and increasing frequency of detectable viral load during follow-up for two years postnatally in w... | ['Adult', 'Anti-Retroviral Agents', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Infant, Newborn', 'Infectious Disease Transmission, Vertical', 'Maternal Health Services', 'Middle Aged', 'Patient Compliance', 'Postnatal Care', 'Pregnancy', 'Retrospective Studies', 'Surveys and Questionnaires', 'Tanzania', 'Viral Loa... | 23,647,555 | [['M01.060.116'], ['D27.505.954.122.388.077'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N06.850.335.875'], ['N02.421.143.620', 'N02.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Rheological alteration of erythrocytes exposed to carbon nanotubes. | Single-walled carbon nanotubes (SWNTs) have been increasingly used in a variety of biomedical applications, such as in vivo delivery of drugs and tumor imaging. Potential exposure of SWNTs to human red blood cells (RBCs) may cause serious toxicity including alteration of mechanical properties of cells. The present stud... | ['Erythrocytes', 'Humans', 'Nanotubes, Carbon', 'Rheology'] | 27,392,849 | [['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['E05.830', 'H01.671.808']] | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Priming of semantic autobiographical knowledge: a case study of retrograde amnesia. | The case of a 36-year-old man who suffers dense retrograde and anterograde amnesia as a result of closed-head injury that caused extensive damage to his left frontal-parietal and right parieto-occipital lobes is described. Patient K.C. has normal intelligence and relatively well-preserved perceptual, linguistic, short-... | ['Adult', 'Amnesia', 'Amnesia, Retrograde', 'Autobiographies as Topic', 'Brain', 'Cues', 'Humans', 'Male', 'Radiography', 'Semantics'] | 3,166,816 | [['M01.060.116'], ['C10.597.606.525.100', 'C23.888.592.604.529.100', 'F01.700.625.100', 'F03.615.200'], ['C10.597.606.525.100.150', 'C23.888.592.604.529.100.150', 'F01.700.625.100.150', 'F03.615.200.150'], ['K01.517.211.215'], ['A08.186.211'], ['F02.463.425.234'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
A diagnostic odyssey: detection of an unusual anterior papillary muscle of the tricuspid valve. | A routine chest X-ray in a 78-year-old female patient suggested a retained vascular catheter in the right ventricle (RV). On transthoracic echocardiography, a prominent linear echo was found in the RV and the patient was referred for cardiac computed tomography and magnetic resonance imaging. Although neither of these ... | ['Aged', 'Echocardiography', 'Echocardiography, Transesophageal', 'Female', 'Foreign Bodies', 'Heart Septal Defects, Atrial', 'Heart Septum', 'Heart Ventricles', 'Humans', 'Magnetic Resonance Imaging', 'Papillary Muscles', 'Tricuspid Valve'] | 20,053,656 | [['M01.060.116.100'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['C26.392'], ['C14.240.400.560.375', 'C14.280.400.560.375', 'C16.131.240.400.560.375'], ['A07.541.459'], ['A07.541.560'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. | Bilirubin is secreted from the liver into bile mainly as monoglucuronosyl and bisglucuronosyl conjugates. We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, als... | ['ATP Binding Cassette Transporter, Subfamily B', 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'ATP-Binding Cassette Transporters', 'Adenosine Triphosphate', 'Animals', 'Bilirubin', 'Biological Transport', 'Carrier Proteins', 'Cell Membrane', 'Humans', 'Kinetics', 'Leukotriene C4', 'Liver', 'Membrane Tran... | 9,355,767 | [['D12.776.157.530.100.075', 'D12.776.157.530.450.074.500.500.250', 'D12.776.395.550.020.400', 'D12.776.543.550.192.400', 'D12.776.543.585.100.200', 'D12.776.543.585.450.074.500.500.250'], ['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High Serum Folate Is Associated with Brain Atrophy in Older Diabetic People with Vitamin B12 Deficiency. | Previous studies have reported the adverse cognitive effects of high folate status in older individuals with vitamin B12 (VB12) deficiency. Thus, the aim of this study was to investigate how high serum folate and VB12 deficiency could collaboratively aggravate neuronal degeneration. In total, 146 older non-demented dia... | ['Aged', 'Brain Diseases', 'Diabetes Complications', 'Female', 'Folic Acid', 'Humans', 'Male', 'Vitamin B 12 Deficiency'] | 29,083,449 | [['M01.060.116.100'], ['C10.228.140'], ['C19.246.099'], ['D03.633.100.733.631.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.521.500.133.699.923']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An alpha modulation index for electroencephalographic studies using complex demodulation. | An automated technique for measuring the relative amount of amplitude modulation of electroencephalographic (EEG) alpha activity is developed to increase the number of existing tools for differentiating the various types of alpha activity. EEG data collected from 12 normal males is used to characterize alpha modulation... | ['Electroencephalography', 'Humans', 'Male', 'Signal Processing, Computer-Assisted'] | 10,912,347 | [['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. | OBJECTIVE: The aim of this study was to evaluate the ability of glucocorticoids to inhibit lymphocyte adhesion to human synovial fibroblasts.METHODS: Adhesion of lymphocytes to cultured synovial fibroblasts was measured by counting the number of cells bound to fibroblasts. Surface expression of intercellular adhesion m... | ['Blotting, Northern', 'Cell Adhesion', 'Cytokines', 'Dexamethasone', 'Enzyme-Linked Immunosorbent Assay', 'Fibroblasts', 'Flow Cytometry', 'Gene Expression', 'Humans', 'Intercellular Adhesion Molecule-1', 'Lymphocytes', 'RNA, Messenger', 'Synovial Membrane', 'Vascular Cell Adhesion Molecule-1'] | 8,849,372 | [['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['G04.022'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.329.228'], ['E01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The association of self-rated health and mortality--a 7-year follow-up study of a Japanese community]. | This study aims to examine whether self-rated health is an independent predictor of cause-specific mortality even after the influence by a variety of factors in relation to mortality reported by previous studies have been excluded. This study included randomly selected 4,259 inhabitants (1,827 men and 2,432 women) in Y... | ['Adult', 'Aged', 'Cause of Death', 'Cohort Studies', 'Community Medicine', 'Female', 'Follow-Up Studies', 'Health Status', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Mortality', 'Proportional Hazards Models', 'Self Concept', 'Surveys and Questionnaires'] | 8,701,113 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['H02.403.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[Psychiatric disorders during adolescence (author's transl)]. | The psychopathology of adolescence shows three areas of dysfunction: 1. maturity deficits with an attitude of protest, loss of motivations, conversion symptomatology, 2. hypochondriac symptoms, obsessive-compulsive features, dysphorias, intellectual-physical handicaps, 3. antisocial behaviour, delinquency, neglect, add... | ['Adolescent', 'Antisocial Personality Disorder', 'Developmental Disabilities', 'Humans', 'Hypochondriasis', 'Mental Disorders', 'Neurotic Disorders', 'Obsessive-Compulsive Disorder', 'Personality Disorders'] | 6,170,177 | [['M01.060.057'], ['F03.675.050'], ['F03.625.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.875.450'], ['F03'], ['F03.080.550', 'F03.650'], ['F03.080.600'], ['F03.675']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Methodical experiences for registration of parameters under ergometric loads of children and young people (author's transl)]. | Evaluation of the cardiovascular capacity is possible by means of bicycle ergometers. An important and useful parameter is the actual heart rate. The author describes the registration of heart rate using modified electrodes for thorax and the advantages of this methodical proceeding are shown. | ['Adolescent', 'Child', 'Electrocardiography', 'Electrodes', 'Heart Rate', 'Humans', 'Physical Exertion', 'Physical Fitness'] | 7,315,624 | [['M01.060.057'], ['M01.060.406'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E07.305.250'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.683'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. | The indolo[2,1- b]quinazoline alkaloid tryptanthrin has previously been identified as the cyclooxygenase-2 (COX-2) inhibitory principle in the extract ZE550 prepared from the medicinal plant Isatis tinctoria (Brassicaceae). We here investigated the potential inhibitory activity of tryptanthrin and ZE550 on COX-2, COX-1... | ['Animals', 'Brassicaceae', 'Cells, Cultured', 'Cyclooxygenase 1', 'Cyclooxygenase 2', 'Cyclooxygenase 2 Inhibitors', 'Cyclooxygenase Inhibitors', 'Dose-Response Relationship, Drug', 'Humans', 'Isoenzymes', 'Leukotriene B4', 'Membrane Proteins', 'Neutrophils', 'Phytotherapy', 'Plant Extracts', 'Prostaglandin-Endoperoxi... | 12,391,548 | [['B01.050'], ['B01.650.940.800.575.912.250.157'], ['A11.251'], ['D08.811.600.720.500'], ['D08.811.600.720.750'], ['D27.505.519.389.310.500', 'D27.505.696.663.850.014.040.500.500.500', 'D27.505.954.158.030.500.500', 'D27.505.954.329.030.500.500'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human hyperimmune globulin protects against the cytotoxic action of staphylococcal alpha-toxin in vitro and in vivo. | Alpha-toxin, the major cytolysin of Staphylococcus aureus, preferentially attacks human platelets and cultured monocytes, thereby promoting coagulation and the release of interleukin-1 and tumor necrosis factor. Titers of naturally occurring antibodies in human blood are not high enough to substantially inhibit these p... | ['Animals', 'Bacterial Toxins', 'Biological Factors', 'Blood Platelets', 'Cells, Cultured', 'Disseminated Intravascular Coagulation', 'Hemolysin Proteins', 'Humans', 'Immunization, Passive', 'Immunoglobulin G', 'Macaca fascicularis', 'Monocytes', 'Monokines', 'Platelet Aggregation', 'Staphylococcus aureus'] | 2,777,380 | [['B01.050'], ['D23.946.123'], ['D23'], ['A11.118.188', 'A15.145.229.188'], ['A11.251'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['D12.776.543.695.444'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400.330', 'E05.478.550.520'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of monocytes in phagocytosis and mixed leukocyte reactivity in human acute myeloid leukemia. | Lymphocyte proliferation, as measured by incorporation of tritiated thymidine (3H-TdR), was significantly enhanced (p less than 0.01) when macrophages sensitized by target myeloblasts were added to monocyte-depleted lymphocyte fractions in the mixed leukocyte reaction (MLR) with human leukemic myeloblasts as stimulator... | ['Cell Separation', 'Dose-Response Relationship, Immunologic', 'Humans', 'Leukemia, Myeloid', 'Lymphocyte Activation', 'Lymphocyte Culture Test, Mixed', 'Male', 'Monocytes', 'Phagocytosis'] | 155,645 | [['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G12.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['E01.370.225.812.385.475', 'E05.200.812.385.475', 'E05.478.594.385.429'], ['A11... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM. | GLUT2 glucose transporter mRNA has been shown to be underexpressed in pancreatic islets of numerous animal models of non-insulin-dependent diabetes mellitus (NIDDM). It has been proposed that this molecular defect contributes to the pathogenesis of diabetes, although information concerning the expression of GLUT2 in hu... | ['Base Sequence', 'Blotting, Northern', 'Blotting, Western', 'Diabetes Mellitus, Type 2', 'Gene Expression', 'Glucose Transporter Type 2', 'Humans', 'Islets of Langerhans', 'Molecular Sequence Data', 'Monosaccharide Transport Proteins', 'Polymerase Chain Reaction', 'Proinsulin', 'RNA, Messenger', 'Tissue Donors'] | 7,589,840 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C18.452.394.750.149', 'C19.246.300'], ['G05.297'], ['D12.776.157.530.500.500.750', 'D12.776.157.530.93... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Operational control of water fluoridation in Niter?i, Rio de Janeiro, Brazil]. | The aim of this study was to evaluate the operational control of water fluoridation at the city water supply plant in Niter?i, Rio de Janeiro, Brazil, from January to December 2000. The water treatment supervisor filled out a questionnaire on the control of water fluoridation. In addition, water samples were collected ... | ['Brazil', 'Fluoridation', 'Fluorides', 'Surveys and Questionnaires', 'Water Supply'] | 12,700,784 | [['Z01.107.757.176'], ['E06.761.382', 'N06.890.235'], ['D01.248.497.158.380', 'D01.303.350.300'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['J01.293.821.500']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Peripheral surgical wounding and age-dependent neuroinflammation in mice. | Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of â-amyloid (Aâ) have been reported to contribute to cognitive dysfunction in humans and cognitive impairment in animals. Our recent studi... | ['Age Factors', 'Amyloid beta-Peptides', 'Animals', 'Anti-Inflammatory Agents', 'Cognition', 'Cognition Disorders', 'Conditioning, Psychological', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'Fear', 'Female', 'Hippocampus', 'Ibuprofen', 'Inflammation', 'Interleukin-6', 'Mice', 'Mice, Inbred C57BL', '... | 24,796,537 | [['N05.715.350.075', 'N06.850.490.250'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['D27.505.954.158'], ['F02.463.188'], ['F03.615.250'], ['F02.463.425.179'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.6... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pathway Grafting for Polyunsaturated Fatty Acids Production in Ashbya gossypii through Golden Gate Rapid Assembly. | Here we present a Golden Gate assembly system adapted for the rapid genomic engineering of the industrial fungus Ashbya gossypii. This biocatalyst is an excellent biotechnological chassis for synthetic biology applications and is currently used for the industrial production of riboflavin. Other bioprocesses such as the... | ['Biomass', 'Eremothecium', 'Fatty Acid Desaturases', 'Fatty Acids, Omega-3', 'Fatty Acids, Unsaturated', 'Gas Chromatography-Mass Spectrometry', 'Metabolic Engineering', 'Plasmids', 'Synthetic Biology'] | 30,261,136 | [['G16.500.275.157.100', 'N06.230.124.100'], ['B01.300.107.795.250', 'B01.300.930.350'], ['D08.811.682.690.708.392'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['D10.251.355'], ['E05.196.181.349.500', 'E05.196.566.500'], ['E05.393.420.526', 'E05.481.500.311.249', 'J01.293.069.249.249'], ['G05.360.6... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Anencephaly does not cause structural alterations in the fetal penis. | INTRODUCTION: Anencephaly is the most severe neural tube defect in human fetuses. There is an increasing need for tissue replacement in chronic diseases and reconstructive surgeries. Fetal tissues have been used as a substitute for native organs.AIM: The aim of this article was to compare the structure and morphology o... | ['Anencephaly', 'Female', 'Fetal Diseases', 'Humans', 'Male', 'Penile Diseases', 'Penis', 'Pregnancy', 'Tissue Donors'] | 22,239,726 | [['C10.500.680.196', 'C16.131.085.197', 'C16.131.666.680.196'], ['C13.703.277', 'C16.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494'], ['A05.360.444.492'], ['G08.686.784.769'], ['M01.898']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stable and Functional Rhomboid Proteases in Lipid Nanodiscs by Using Diisobutylene/Maleic Acid Copolymers. | Rhomboid proteases form a paradigm for intramembrane proteolysis and have been implicated in several human diseases. However, their study is hampered by difficulties in solubilization and purification. We here report on the use of polymers composed of maleic acid and either diisobutylene or styrene for solubilization o... | ['Alkenes', 'Humans', 'Lipids', 'Maleates', 'Models, Molecular', 'Molecular Structure', 'Nanoparticles', 'Particle Size', 'Polymers', 'Serine Proteases', 'Small Molecule Libraries'] | 30,347,979 | [['D02.455.326.271'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10'], ['D02.241.081.337.502'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['J01.637.512.600'], ['G02.712'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D08.811.277.656.959'], ['D27.720.470.765']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Trade-offs between activity and thermoregulation in a small carnivore, the least weasel Mustela nivalis. | We studied factors influencing daily energy expenditures (DEE) of male least weasels (Mustela nivalis) using the doubly labelled water technique. The relationship between ambient temperature and DEE formed a triangular pattern, characterized by invariance of the maximum DEE and an inverse relationship between minimum D... | ['Animals', 'Behavior, Animal', 'Body Size', 'Body Temperature Regulation', 'Energy Metabolism', 'Feeding Behavior', 'Male', 'Models, Biological', 'Mustelidae', 'Regression Analysis', 'Seasons', 'Temperature'] | 19,324,766 | [['B01.050'], ['F01.145.113'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['G03.295'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['E05.599.395'], ['B01.050.150.900.649.313.750.250.575'], ['E05.318.740.750', 'N05.7... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Therapeutic Interferon Interchange in Relapsing Multiple Sclerosis Lowers Health Care and Pharmacy Expenditures with Comparable Safety. | INTRODUCTION: For patients with a less-active (fewer relapses or complete recovery from relapses, less radiologic burden of disease, or no or limited disease-related disability) relapsing form of multiple sclerosis (MS), interferon (IFN) beta-1b subcutaneous is similar in efficacy to IFN beta-1a intramuscular and subcu... | ['Antiviral Agents', 'Female', 'Health Expenditures', 'Humans', 'Interferons', 'Male', 'Middle Aged', 'Multiple Sclerosis, Relapsing-Remitting', 'Retrospective Studies', 'Severity of Illness Index', 'Treatment Outcome'] | 30,201,091 | [['D27.505.954.122.388'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440', 'D12.776.467.374.440', 'D23.529.374.440'], ['M01.060.116.630'], ['C10.114.375.500.600', 'C10.314.350.500.600', 'C20.111.258.250.500.600'], ['E05.318.372.500.500.500', 'E05.318.372.500.7... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Sequelae of injuries on the lower urogenital system]. | A description of aetiology, symptomatology, and diagnosis of traumatic lesions of the bladder, urethra, and genital organs is followed by a critical discussion of therapy. Contributions to these topics coming from round-table discussions, held at several international urological meetings during the past few years, are ... | ['Abdominal Injuries', 'Adult', 'Child', 'Erectile Dysfunction', 'Female', 'Humans', 'Intussusception', 'Male', 'Penis', 'Postoperative Complications', 'Urethra', 'Urinary Bladder', 'Urinary Incontinence', 'Urogenital System'] | 991,699 | [['C26.017'], ['M01.060.116'], ['M01.060.406'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531.577'], ['A05.360.444.492'], ['C23.550.767'], ['A05.360.444.492.726', 'A05.810.876'], ['A05.810.890'], ['C12.777.934.852', 'C13.351.968.934.814', 'C23.888.942.343.800'], ... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mibefradil in the treatment of chronic stable angina pectoris: comparative studies with other calcium antagonists. | The ability of mibefradil, a new T-channel-selective calcium antagonist, to improve exercise tolerance and silent ischemic parameters in patients with chronic stable angina was compared in 3 separate trials with 2 other commonly used calcium antagonists: diltiazem SR (120 mg/twice daily) and amlodipine (10 mg/day). Com... | ['Adult', 'Aged', 'Aged, 80 and over', 'Amlodipine', 'Angina Pectoris', 'Benzimidazoles', 'Calcium Channel Blockers', 'Chronic Disease', 'Diltiazem', 'Female', 'Hemodynamics', 'Humans', 'Male', 'Mibefradil', 'Middle Aged', 'Nitroglycerin', 'Tetrahydronaphthalenes'] | 9,286,852 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D03.383.725.203.065'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['D03.633.100.103'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['C23.550.291.500'], ['D03.633.100.079.150'], ['G09.330.380'], ['B01.050... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
1,4-Dioxane and ergosterol derivatives from Withania somnifera roots. | The chemical investigation on the n-hexane extract of Withania somnifera roots has yielded octacosane, oleic and stearic fatty acids, stigmasterone, stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds. The isolation of alkenyl-1,4-dioxane compound is rare, wh... | ['Dioxanes', 'Ergosterol', 'Hexanes', 'Molecular Structure', 'Plant Roots', 'Withania'] | 22,263,592 | [['D03.383.188'], ['D04.210.500.247.222.537'], ['D02.455.326.146.500'], ['G02.111.570', 'G02.466'], ['A18.400'], ['B01.650.940.800.575.912.250.908.500.950']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation. | 1. Cholinesterase inhibitors potentiated twitch responses induced by nerve stimulation, with physostigmine more potent than tacrine and velnacrine. However, at higher concentrations, tacrine decreased twitch responses in a concentration-dependent manner. 2. Tacrine strongly depressed directly-induced twitch responses, ... | ['Animals', 'Cholinesterase Inhibitors', 'Electric Stimulation', 'In Vitro Techniques', 'Male', 'Muscle Contraction', 'Neuromuscular Blocking Agents', 'Neuromuscular Junction', 'Phrenic Nerve', 'Physostigmine', 'Rats', 'Rats, Sprague-Dawley', 'Respiratory Muscles', 'Tacrine'] | 8,270,168 | [['B01.050'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['E05.723.402'], ['E05.481'], ['G11.427.494'], ['D27.505.696.663.700.710'], ['A08.800.550.550.550', 'A08.850.550.550', 'A11.284.149.165.420.780.550.550'], ['A08.800.800.720.150.700'], ['D02.241.081.251.583.682', 'D03.132.436.54... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preoperative luteinizing hormone levels predict the ovulatory response to laparoscopic ovarian drilling in patients with clomiphene citrate-resistant polycystic ovary syndrome. | OBJECTIVE: Laparoscopic ovarian drilling (LOD) is a treatment option for women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS), but appropriate indications for this procedure are lacking. The aim of this study was to analyze preoperative factors affecting the efficacy of LOD in producing ovulati... | ['Adult', 'Clomiphene', 'Cohort Studies', 'Drug Resistance', 'Electrocoagulation', 'Female', 'Fertility Agents, Female', 'Humans', 'Laparoscopy', 'Luteinizing Hormone', 'Ovary', 'Ovulation', 'Polycystic Ovary Syndrome', 'Predictive Value of Tests', 'Preoperative Care', 'Retrospective Studies', 'Treatment Outcome'] | 16,390,777 | [['M01.060.116'], ['D02.455.426.559.389.150.700.125'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G07.690.773.984'], ['E02.154.402', 'E04.014.170.402'], ['D27.505.696.875.552.344', 'D27.505.954.705.552.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accidental childhood deaths. The Metropolitan Dade County experience, 1978-1982. | Accidental deaths in childhood were studied between 1978 and 1982 in Metropolitan Dade County. Cases were collected from both traffic and nontraffic accidental fatalities in which the victim was less than 12 years of age. Cases were then subdivided into traffic and nontraffic groups. Each group was then analyzed as to ... | ['Accidents', 'Accidents, Traffic', 'Child', 'Child, Preschool', 'Female', 'Florida', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mortality'] | 3,740,004 | [['N06.850.135'], ['N06.850.135.392'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.107.567.875.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550']] | ['Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Unemployment and suicide during and after a deep recession: a longitudinal study of 3.4 million Swedish men and women. | OBJECTIVES: We tested 2 hypotheses found in studies of the relationship between suicide and unemployment: causal (stress and adversity) and selective interpretation (previous poor health).METHODS: We estimated Cox models for adults (n = 3,424,550) born between 1931 and 1965. We examined mortality during the recession (... | ['Adult', 'Economic Recession', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Proportional Hazards Models', 'Registries', 'Suicide', 'Sweden', 'Unemployment'] | 23,597,379 | [['M01.060.116'], ['I01.261.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.998.825', 'E05.599.835.900', 'N05.715.360... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Family nutrition program assistants' perception of farmers' markets, alternative agricultural practices, and diet quality. | OBJECTIVE: To explore Family Nutrition Program assistants' perception of farmers' markets and alternative agricultural practices for themselves and their clients.METHODS: Cross-section design, survey of Virginia Expanded Food and Nutrition Education Program (NEP) and Supplemental Nutrition Assistance Program-Education ... | ['Agriculture', 'Attitude of Health Personnel', 'Commerce', 'Cross-Sectional Studies', 'Diet', 'Family', 'Female', 'Food Assistance', 'Food Supply', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Poverty', 'Virginia'] | 24,751,655 | [['J01.040'], ['F01.100.050', 'N05.300.100'], ['J01.219'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['F01.829.263', 'I01.880.853.150'], ['I01.880.787.839.500', 'N03.219.521.346.506.281'], ['J01.576.423.750'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.15... | ['Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Study of infant milk formulas present on the Spanish market and its adaptation to the recommendations of the European Society of Gastroenterology and Pediatric Nutrition]. | The aim of this study was to investigate energy as well as the protein and mineral composition of milk formulas available on the Spanish market. We studied 20 milk formulas, 14 of which were adapted milk formulas intended for feeding newborns during the first 4-6 months of life and the other 6 ones were follow-up milk ... | ['Energy Intake', 'Humans', 'Infant', 'Infant Food', 'Minerals', 'Proteins', 'Spain'] | 3,826,944 | [['G07.203.650.240.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G07.203.300.525.500', 'J02.500.525.500'], ['D01.578'], ['D12.776'], ['Z01.542.846']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
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