pmid int64 7.11M 40.4M | title stringlengths 1 553 | abstract stringlengths 200 10.9k | journal stringlengths 3 239 | pub_year int64 1.98k 2.02k | pub_month int64 1 12 | citation_count_within_one_year int64 0 281 | citation_count_within_five_years int64 0 1.17k |
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29,328,521 | Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies. | In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological sp... | Annals of neurology | 2,018 | 2 | 13 | 123 |
26,335,190 | Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission. | Amyotrophic lateral sclerosis (ALS) is a disease leading to neuromuscular transmission impairment. A2A adenosine receptor (A2AR) function changes with disease stage, but the role of the A(1) receptors (A1Rs) is unknown and may have a functional cross-talk with A2AR. The role of A1R in the SOD1(G93A) mouse model of ALS ... | Purinergic signalling | 2,015 | 12 | 0 | 15 |
19,026,951 | cis-4-[(18)F]-Fluoro-l-proline fails to detect peripheral tumors in humans. | System A amino acid transport is increased in transformed and malignant cells. The amino acid 4-cis[(18)F]fluoro-l-proline (cis-[(18)F]FPro) has been shown to be a substrate of the System A amino acid carrier. In this pilot study, we investigated the diagnostic potential of cis-[(18)F]FPro in patients with various tumo... | Nuclear medicine and biology | 2,008 | 11 | 0 | 2 |
30,176,349 | Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. | Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive and behavioral impairments in humans. We have previously shown that the... | Neurobiology of disease | 2,018 | 12 | 2 | 6 |
27,403,728 | Stripe Assay to Study the Attractive or Repulsive Activity of a Protein Substrate Using Dissociated Hippocampal Neurons. | Growing axons develop a highly motile structure at their tip, termed the growth cone. The growth cone contacts extracellular environmental cues to navigate axonal growth. Netrin, slit, semaphorin, and ephrins are known guidance molecules that can attract or repel axons upon binding to receptors and co-receptors on the ... | Journal of visualized experiments : JoVE | 2,016 | 6 | 0 | 6 |
24,849,347 | Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation. | Impulsivity, risk-taking behavior, and elevated stress responsivity are prominent symptoms of mania, a behavioral state common to schizophrenia and bipolar disorder. Though inflammatory processes activated within the brain are involved in the pathophysiology of both disorders, the specific mechanisms by which neuroinfl... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,014 | 5 | 1 | 14 |
28,703,074 | Serum ionic dysequilibria in clinical opioid dependence: Cross-sectional and longitudinal studies. | Despite an increasing awareness that the activity of excitable membranes is determined by the underlying ionic gradients across them, and their importance in drug dependency, we were not able to identify any reports of comparing the electrolyte composition of opioid-dependent and non-addicted controls. | Human & experimental toxicology | 2,017 | 8 | 0 | 1 |
29,953,199 | DARK Classics in Chemical Neuroscience: Phencyclidine (PCP). | Phencyclidine (PCP, "angel dust", an arylcyclohexylamine) was the first non-natural, man-made illicit drug of abuse, and was coined 'the most dangerous drug in America" in the late 1970s (amidst sensational horror stories of the drug's effects); however, few other illicit drugs have had such a significant and broad imp... | ACS chemical neuroscience | 2,018 | 10 | 1 | 29 |
29,301,039 | Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis. | Studies using positron emission tomography to image striatal dopamine function, have demonstrated that individuals with schizophrenia display increases in presynaptic function. Mesolimbic dysfunction specifically, has previously been suggested to underlie psychotic symptoms. This has not been directly tested in vivo, a... | Schizophrenia bulletin | 2,018 | 10 | 14 | 167 |
29,940,255 | Suppressing cortisol at encoding reduces the emotional enhancement in subjective sense of recollection. | The stress hormone cortisol, released when encountering an emotional event, contributes to form a strong emotional memory. Such emotionally arousing memories are recalled with an enhanced subjective sense of recollection, i.e. experienced in memory as more vivid and richer in details. We examined here whether cortisol ... | Neurobiology of learning and memory | 2,018 | 11 | 2 | 6 |
24,343,520 | Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation. | The choroid plexuses (CP) release numerous biologically active enzymes and neurotrophic factors, and contain a subpopulation of neural progenitor cells providing the capacity to proliferate and differentiate into other types of cells. These characteristics make CP epithelial cells (CPECs) excellent candidates for cell ... | Cellular and molecular life sciences : CMLS | 2,014 | 8 | 3 | 14 |
27,916,440 | Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia. | The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling ... | Brain research | 2,017 | 2 | 1 | 5 |
32,236,692 | Cognitive swarming in complex environments with attractor dynamics and oscillatory computing. | Neurobiological theories of spatial cognition developed with respect to recording data from relatively small and/or simplistic environments compared to animals' natural habitats. It has been unclear how to extend theoretical models to large or complex spaces. Complementarily, in autonomous systems technology, applicati... | Biological cybernetics | 2,020 | 4 | 3 | 21 |
31,161,314 | Atrophy of cerebellar peduncles in essential tremor: a machine learning-based volumetric analysis. | Subtle cerebellar signs are frequently observed in essential tremor (ET) and may be associated with cerebellar dysfunction. This study aims to evaluate the macrostructural integrity of the superior, middle, and inferior cerebellar peduncles (SCP, MCP, ICP) and cerebellar gray and white matter (GM, WM) volumes in patien... | European radiology | 2,019 | 12 | 0 | 18 |
32,217,087 | Lower scores in pharmacokinetics than in pharmacodynamics assessment among students in a health and life sciences curriculum. | In pharmacology teaching, pharmacokinetics (PK) and pharmacodynamics (PD) may be defined as part of the 'general pharmacology' domain, whereas effects of drugs on the autonomic nervous system and clinical trial design might be defined as part of the 'medical' and 'clinical' pharmacology domain, respectively. We recentl... | European journal of pharmacology | 2,020 | 6 | 0 | 2 |
34,078,342 | The effects on self-efficacy, motivation and perceived barriers of an intervention targeting physical activity and sedentary behaviours in office workers: a cluster randomized control trial. | The importance of physical activity on health is clear, but changing behaviour is difficult. Successful interventions aiming to improve physical activity and reduce sedentary behaviour is therefore of importance. The aim of this study was to evaluate effects on motivation, self-efficacy and barriers to change behaviour... | BMC public health | 2,021 | 6 | 2 | 16 |
31,512,720 | Sex Differences in Functional Brain Networks for Language. | Men and women process language differently, but how the brain functions to support this difference is poorly understood. A few studies reported sex influences on brain activation for language, whereas others failed to detect the difference at the functional level. Recent advances of brain network analysis have shown gr... | Cerebral cortex (New York, N.Y. : 1991) | 2,020 | 3 | 2 | 28 |
33,421,070 | Insulin Resistance in Congenital Adrenal Hyperplasia is Compensated for by Reduced Insulin Clearance. | Congenital adrenal hyperplasia (CAH) patients have potential normal longevity. However, a greater risk for cardiovascular disease has been reported. Insulin resistance and hyperinsulinemia have been described in CAH patients, whereas the prevalence of overt type 2 diabetes is not higher in CAH than in normal population... | The Journal of clinical endocrinology and metabolism | 2,021 | 3 | 2 | 12 |
27,685,658 | Clinical outcome and intraoperative neurophysiology for focal limb dystonic tremor without generalized dystonia treated with deep brain stimulation. | Dystonic tremor (DT) is defined as a postural/kinetic tremor occurring in the body region affected by dystonia. DT is typically characterized by focal tremors with irregular amplitudes and variable frequencies typically below 7Hz. Pharmacological treatment is generally unsuccessful and guidelines for deep brain stimula... | Clinical neurology and neurosurgery | 2,016 | 11 | 0 | 7 |
25,040,939 | In Vitro Assessment with the Infrared Thermometer of Temperature Differences Generated During Implant Site Preparation: The Traditional Technique Versus the Single-Drill Technique. | To assess in vitro, using an infrared (IR) thermometer, temperature changes generated at implant sites by osteotomies involving two different drilling methods (with multiple drills versus only one) and to measure the influence of irrigation on the temperature variation. | Clinical implant dentistry and related research | 2,016 | 2 | 0 | 16 |
32,088,296 | Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients With Bile Acid Diarrhea in a Randomized Trial. | Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of colesevelam on bowel functions, consistent with luminal BA sequestration by colesevelam. We compared the effects of colesevelam vs placebo on symptoms and gene expre... | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association | 2,020 | 12 | 6 | 30 |
21,382,453 | Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus. | Circadian (24-h) rhythms influence virtually every aspect of mammalian physiology. The main rhythm generation center is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and work over the past several years has revealed that rhythmic gene transcription and post-translational processes are central to clo... | Neuroscience | 2,011 | 5 | 0 | 24 |
33,425,653 | Child Sexual Abuse and Compulsive Sexual Behavior: A Systematic Literature Review. | Information on potential risk factors and clinical correlates of compulsive sexual behavior (CSB) may help inform more effective prevention and treatment measures. Sexual victimization, specifically, child sexual abuse (CSA), has been associated with CSB. | Current addiction reports | 2,020 | 3 | 4 | 57 |
31,304,985 | Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. | Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulatio... | The EMBO journal | 2,019 | 9 | 7 | 49 |
29,037,972 | Sex differences in circuits activated by corticotropin releasing factor in rats. | Women are more likely than men to suffer from psychiatric disorders characterized by corticotropin releasing factor (CRF) hypersecretion, suggesting sex differences in CRF sensitivity. In rodents, sex differences in the sensitivity of specific brain regions to CRF have been identified. However, regions do not work in i... | Hormones and behavior | 2,018 | 1 | 6 | 37 |
30,091,267 | Comparative analysis of decidual and peripheral immune cells and immune-checkpoint molecules during pregnancy in wild-type and PACAP-deficient mice. | PACAP is a neuropeptide having a major relevance in the nervous system and in several peripheral organs including those of the reproductive system. PACAP-deficient mice have several morphological, biochemical, behavioral defects, and show reduced fertility. Female reproductive functions such as fertility, mating behavi... | American journal of reproductive immunology (New York, N.Y. : 1989) | 2,018 | 10 | 4 | 11 |
21,802,444 | Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: old and new vistas. | The possible involvement of salsolinol (Sal), an endogenous condensation product of ACD (the first metabolite of ethanol) and dopamine, in the neurochemical basis underlying ethanol action has been repeatedly suggested although it has not been unequivocally established, still being a controversial matter of debate. The... | Neuroscience and biobehavioral reviews | 2,012 | 1 | 3 | 21 |
28,049,425 | The variability of motor evoked potential latencies in neurosurgical motor mapping by preoperative navigated transcranial magnetic stimulation. | Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying MEP latency variability in neurosurgical motor mapping are vastly unknown. In the context of this study, one hu... | BMC neuroscience | 2,017 | 1 | 2 | 18 |
28,204,568 | Differential Gene Expression in the Human Brain Is Associated with Conserved, but Not Accelerated, Noncoding Sequences. | Previous studies have found that genes which are differentially expressed within the developing human brain disproportionately neighbor conserved noncoding sequences (CNSs) that have an elevated substitution rate in humans and in other species. One explanation for this general association of differential expression wit... | Molecular biology and evolution | 2,017 | 5 | 5 | 7 |
22,668,988 | Can the default-mode network be described with one spatial-covariance network? | The default-mode network (DMN) has become a well accepted concept in cognitive and clinical neuroscience over the last decade, and perusal of the recent literature attests to a stimulating research field of cognitive and diagnostic applications (for example, (Andrews-Hanna et al., 2010; Koch et al., 2010; Sheline et al... | Brain research | 2,012 | 8 | 1 | 5 |
19,965,853 | Impaired sensorimotor integration in focal hand dystonia patients in the absence of symptoms. | Functional imaging studies of people with focal hand dystonia (FHD) have indicated abnormal activity in sensorimotor brain regions. Few studies however, have examined FHD during movements that do not provoke symptoms of the disorder. It is possible, therefore, that any differences between FHD and controls are confounde... | Journal of neurology, neurosurgery, and psychiatry | 2,010 | 6 | 3 | 27 |
19,269,697 | The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. | Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators. Because it can be induced by inflammatory stimuli, COX-2 has been classically considered as the most appropriate target for anti-inflammatory drugs. However, recent data indicate that COX... | Trends in pharmacological sciences | 2,009 | 4 | 15 | 103 |
30,930,077 | Distribution, nature, and origin of CXCL14-immunoreactive fibers in rat parotid gland. | The distribution and nature of CXCL14-immunoreactive nerve fibers in salivary glands, especially the parotid gland was immunohistochemically investigated. Furthermore, the origin of parotid CXCL14-immunoreactive nerve fibers was determined by retrograde tracing experiments. CXCL14-immunoreactive nerve fibers were local... | Neuroscience letters | 2,019 | 6 | 1 | 2 |
25,802,982 | Arc expression identifies the lateral amygdala fear memory trace. | Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood. Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during... | Molecular psychiatry | 2,016 | 3 | 7 | 33 |
31,586,834 | Measuring subthreshold autistic traits in the general population: Psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum) scale. | The Adult Autism Subthreshold Spectrum (AdAS Spectrum) has been developed to assess the wide spectrum of autistic-like clinical and non-clinical features in adults. Nevertheless, its psychometric properties have been analyzed only with clinical individuals so far. This study was aimed at investigating the dimensionalit... | Psychiatry research | 2,019 | 11 | 0 | 19 |
26,133,572 | Computer Game Play Reduces Intrusive Memories of Experimental Trauma via Reconsolidation-Update Mechanisms. | Memory of a traumatic event becomes consolidated within hours. Intrusive memories can then flash back repeatedly into the mind's eye and cause distress. We investigated whether reconsolidation-the process during which memories become malleable when recalled-can be blocked using a cognitive task and whether such an appr... | Psychological science | 2,015 | 8 | 8 | 105 |
30,755,602 | Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. | Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to cognate tRNA molecules, which are required for protein translation. To date, biallelic mutations in 31 ARS genes are known to cause recessive, early-onset severe multi-organ diseases. VARS encodes the only known valine cytoplasmic-localized aminoacyl... | Nature communications | 2,019 | 2 | 5 | 29 |
31,194,249 | Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder. | Rapid eye movement (REM) sleep without atonia (RWA) is the main polysomnographic feature of idiopathic REM sleep behavior disorder (iRBD) and is considered to be a promising biomarker predicting conversion to manifested synucleinopathy. Besides conventionally evaluated tonic, phasic and any RWA, we took into considerat... | Sleep | 2,019 | 9 | 0 | 31 |
30,298,238 | Neural correlates of proactive and reactive inhibition of saccadic eye movements. | Although research on goal-directed, proactive inhibitory control (IC) and stimulus-driven, reactive IC is growing, no previous study has compared proactive IC in conditions of uncertainty with regard to upcoming inhibition to conditions of certain upcoming IC. Therefore, we investigated effects of certainty and uncerta... | Brain imaging and behavior | 2,020 | 2 | 1 | 8 |
32,393,896 | Brainstem neurons that command mammalian locomotor asymmetries. | Descending command neurons instruct spinal networks to execute basic locomotor functions, such as gait and speed. The command functions for gait and speed are symmetric, implying that a separate unknown system directs asymmetric movements, including the ability to move left or right. In the present study, we report tha... | Nature neuroscience | 2,020 | 6 | 22 | 107 |
26,338,334 | Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17. | The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders. We recently described an essential function for TACE/ADAM17 in regulating oligodendrogenesis during postnatal myelinati... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,015 | 9 | 1 | 12 |
25,554,223 | Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines. | Glioblastoma (GBM) is a highly proliferative, angiogenic grade IV astrocytoma that develops resistance to the alkylating agents used in chemotherapy, such as temozolomide (TMZ), which is considered the gold standard. The mean survival time for GBM patients is approximately 12 months, increasing to 14.6 months after TMZ... | Biochimica et biophysica acta | 2,015 | 4 | 1 | 20 |
25,529,145 | Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study. | Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced toxicity has been lacking. Thus, the purpose of this study was ... | Life sciences | 2,015 | 2 | 3 | 24 |
28,417,277 | Clandestine charisma of the charm needles: a radiologist's challenge. | A 94-year-old Korean woman was seen in the Emergency Department after a fall. CT examination of the maxillofacial region found multiple small linear metallic densities in the subcutaneous soft tissues of the face. The appearance of these densities was unchanged when compared to a study performed 2 years prior; however,... | Emergency radiology | 2,017 | 8 | 0 | 2 |
26,808,560 | Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. | Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy) for each single nu... | PLoS genetics | 2,016 | 1 | 4 | 27 |
9,252,004 | Mechanical and thermal allodynia in chronic central pain following spinal cord injury. | Spinal cord injury (SCI) results in variable motor recoveries and chronic central pain syndromes develop in the majority of SCI patients. To provide a basis for further studies, we report a new rodent model of chronic central pain following spinal cord trauma. Male Sprague-Dawley rats (N = 10) were hemisectioned at T13... | Pain | 1,996 | 11 | 3 | 22 |
18,571,437 | A Bayesian framework to identify principal intravoxel diffusion profiles based on diffusion-weighted MR imaging. | In this paper we introduce a new method to characterize the intravoxel anisotropy based on diffusion-weighted imaging (DWI). The proposed solution, under a fully Bayesian formalism, deals with the problem of joint Bayesian Model selection and parameter estimation to reconstruct the principal diffusion profiles or prima... | NeuroImage | 2,008 | 8 | 1 | 9 |
28,220,213 | Labour market marginalisation subsequent to suicide attempt in young migrants and native Swedes. | This study aimed to compare young individuals who differed in terms of birth region and history of suicide attempt regarding socio-demographic and healthcare factors, and with regard to their risks of subsequent unemployment, sickness absence and disability pension. | Social psychiatry and psychiatric epidemiology | 2,017 | 5 | 1 | 8 |
27,683,884 | Transmission of auditory sensory information decreases in rate and temporal precision at the endbulb of Held synapse during age-related hearing loss. | Age-related hearing loss (ARHL) is largely attributed to structural changes and functional declines in the peripheral auditory system, which include synaptopathy at the inner hair cell/spiral ganglion cell (SGC) connection and the loss of SGCs. However, functional changes at the central terminals of SGCs, namely the au... | Journal of neurophysiology | 2,016 | 12 | 1 | 17 |
29,082,858 | An Internet-Based Intervention for Chronic Pain. | Persons with chronic pain can be treated effectively with acceptance and commitment therapy (ACT). In this trial, we examined the effectiveness of guided and unguided ACT-based online treatment (ACTonPain) for chronic pain patients. | Deutsches Arzteblatt international | 2,017 | 10 | 8 | 58 |
26,557,360 | Habituation of Auditory Steady State Responses Evoked by Amplitude-Modulated Acoustic Signals in Rats. | Generation of the auditory steady state responses (ASSR) is commonly explained by the linear combination of random background noise activity and the stationary response. Based on this model, the decrease of amplitude that occurs over the sequential averaging of epochs of the raw data has been exclusively linked to the ... | Audiology research | 2,015 | 1 | 0 | 6 |
28,135,884 | Intranasal administration of dopamine attenuates unconditioned fear in that it reduces restraint-induced ultrasound vocalizations and escape from bright light. | Although substantial evidence suggests that dopamine (DA) enhances conditioned fear responses, few studies have examined the role of DA in unconditioned fear states. Whereas DA does not cross the blood-brain barrier, intranasally-applied dopamine reaches the brain directly via the nose-brain pathways in rodents, provid... | Journal of psychopharmacology (Oxford, England) | 2,017 | 6 | 1 | 5 |
18,707,031 | Neurochemical phenotypes of cardiorespiratory neurons. | Interactions between the cardiovascular and respiratory systems have been known for many years but the functional significance of the interactions is still widely debated. Here I discuss the possible role of metabotropic receptors in regulating cardiorespiratory neurons in the brainstem and spinal cord. It is clear tha... | Respiratory physiology & neurobiology | 2,008 | 12 | 1 | 2 |
23,547,559 | Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation. | The cortical silent period (CSP) elicited by transcranial magnetic stimulation (TMS) is affected by changes in TMS intensity. Some studies have shown that CSP is shortened or prolonged by short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), Those studies, however, used different TMS inte... | BMC neuroscience | 2,013 | 4 | 0 | 12 |
25,585,013 | Targeting the sigma-1 receptor chaperone in the treatment of perinatal brain injury. | Glutamate-induced excitotoxicity via the N-methyl-d-aspartate (NMDA) receptor is an important factor in the pathogenesis of perinatal brain injury. The sigma-1 receptor on the endoplasmic reticulum (ER) has been known to affect the function of the NMDA receptor. 4-Phenyl-1-(4-phenylbutyl)piperidine (PPBP) has been inve... | Experimental neurology | 2,015 | 3 | 0 | 1 |
26,893,077 | Basal ganglia correlates of fatigue in young adults. | Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and pref... | Scientific reports | 2,016 | 2 | 0 | 17 |
30,574,817 | Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer. | Endometrial cancer (EC) is the most common neoplasm of the female genital tract in developed countries. Despite the progress in early detection and treatment, a significant number of cases of advanced ECs are still diagnosed. These patients have few treatment options and a poor prognosis. Our understanding of EC pathog... | Expert opinion on investigational drugs | 2,019 | 2 | 3 | 55 |
31,036,823 | Macroscale cortical organization and a default-like apex transmodal network in the marmoset monkey. | Networks of widely distributed regions populate human association cortex. One network, often called the default network, is positioned at the apex of a gradient of sequential networks that radiate outward from primary cortex. Here, extensive anatomical data made available through the Marmoset Brain Architecture Project... | Nature communications | 2,019 | 4 | 18 | 70 |
25,070,925 | Influence of ketamine-xylazine anaesthesia on cubic and quadratic high-frequency distortion-product otoacoustic emissions. | Ketamine is a dissociative anaesthetic, analgesic drug as well as an N-methyl-D-aspartate receptor antagonist and has been reported to influence otoacoustic emission amplitudes. In the present study, we assess the effect of ketamine-xylazine on high-frequency distortion-product otoacoustic emissions (DPOAE) in the bat ... | Journal of the Association for Research in Otolaryngology : JARO | 2,014 | 10 | 1 | 3 |
33,955,711 | Chemogenetic suppression of anterior cingulate cortical neurons projecting to the visual cortex disrupts attentional behavior in mice. | Attention is a goal-directed cognitive process that facilitates the detection of task-relevant sensory stimuli from dynamic environments. Anterior cingulate cortical area (ACA) is known to play a key role in attentional behavior, but the specific circuits mediating attention remain largely unknown. As ACA modulates sen... | Neuropsychopharmacology reports | 2,021 | 6 | 1 | 7 |
21,543,609 | Functional organization of the thalamic input to the thalamic reticular nucleus. | Most axons connecting the thalamus and cortex in both directions pass through the thalamic reticular nucleus (TRN), a thin layer of GABAergic cells adjacent to the thalamus, and innervate neurons there. The TRN, therefore, is in a strategic location to regulate thalamocortical communication. We recorded neurons of the ... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,011 | 5 | 3 | 25 |
19,819,307 | Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats. | It is important to investigate the effect of anesthesia on blood oxygenation level-dependent (BOLD) signals in an animal model. Many researchers have investigated the BOLD response to visual, sensory, and chemical stimuli in anesthetized rats. There are no reports, however, comparing the differences in the BOLD signal ... | Neuroscience | 2,010 | 1 | 3 | 28 |
22,352,396 | Predicting word reading and comprehension with executive function and speed measures across development: a latent variable analysis. | The present study explored whether different executive control and speed measures (working memory, inhibition, processing speed, and naming speed) independently predict individual differences in word reading and reading comprehension. Although previous studies suggest these cognitive constructs are important for readin... | Journal of experimental psychology. General | 2,012 | 8 | 7 | 78 |
24,703,099 | Long-term remission with rituximab in refractory leucine-rich glioma inactivated 1 antibody encephalitis. | Autoimmune encephalitis associated with antibodies to leucine-rich glioma inactivated 1 (LGI1) is recently described and there is a lack of detailed reports on the treatment of relapsing or refractory cases and long-term outcomes. Two case reports are presented. Both cases had faciobrachial dystonic seizures (FBDS) and... | Journal of neuroimmunology | 2,014 | 6 | 3 | 13 |
28,637,276 | Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. | Significant transcriptome alterations are detected in the brain of patients with amyotrophic lateral sclerosis (ALS), including carriers of the C9orf72 repeat expansion and C9orf72-negative sporadic cases. Recently, the expression of repetitive element transcripts has been associated with toxicity and, while increased ... | Human molecular genetics | 2,017 | 9 | 14 | 68 |
23,485,869 | Acute on chronic exposure to endotoxin is associated with enhanced chemoreflex responses in preterm fetal sheep. | There is increasing evidence that exposure to infection can sensitize the fetus to subsequent hypoxic injury. However, it is unclear whether this involves compromise of the fetal cardiovascular adaptation to acute asphyxia. Chronically instrumented 103-day-old (0.7 gestational age, term is 147 days) fetal sheep in uter... | American journal of physiology. Regulatory, integrative and comparative physiology | 2,013 | 5 | 1 | 6 |
26,935,401 | Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina. | To replace photoreceptors lost to disease or trauma and restore vision, laboratories around the world are investigating photoreceptor replacement strategies using subretinal transplantation of photoreceptor precursor cells (PPCs) and retinal progenitor cells (RPCs). Significant obstacles to advancement of photoreceptor... | Scientific reports | 2,016 | 3 | 0 | 12 |
18,977,429 | Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. | We describe here the repertoire of neuropeptide Y (NPY) peptides and receptors in the elephant shark Callorhinchus milii, belonging to the chondrichthyans that diverged from the rest of the gnathostome (jawed vertebrate) lineage about 450 million years ago and the first chondrichthyan with a genome project. We have ide... | Genomics | 2,009 | 3 | 0 | 30 |
27,452,460 | The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. | Striatal medium-sized spiny neurons (MSNs), composed of striatonigral and striatopallidal neurons, are derived from the lateral ganglionic eminence (LGE). We find that the transcription factor Sp9 is expressed in LGE progenitors that generate nearly all striatal MSNs and that Sp9 expression is maintained in postmitotic... | Cell reports | 2,016 | 8 | 3 | 40 |
21,712,072 | Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression. | Patients suffering from depression frequently display hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) resulting in elevated cortisol levels. One main symptom of this condition is anhedonia. There is evidence that exercise training can be used as a rehabilitative intervention in the treatment of depressiv... | Neuroscience | 2,011 | 9 | 4 | 39 |
23,575,225 | The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. | TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal dementia-frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP). To date, the C-terminus of TDP-43, which is ... | Human molecular genetics | 2,013 | 8 | 3 | 53 |
19,406,469 | Lipids in Ca2+ signalling--an introduction. | Lipids and lipid-derived metabolites are increasingly recognised as bonafide signalling molecules that regulate many cellular processes. These include the well-established InsP(3), diacylglycerol (DAG), PIP(2), PIP(3) and arachidonic acid (AA), as well as other poly-unsaturated fatty acids (PUFAs), lysophospholipids, s... | Cell calcium | 2,009 | 6 | 0 | 4 |
26,633,367 | Neuropeptide Trefoil Factor 3 Reverses Depressive-Like Behaviors by Activation of BDNF-ERK-CREB Signaling in Olfactory Bulbectomized Rats. | The trefoil factors (TFFs) are a family of three polypeptides, among which TFF1 and TFF3 are widely distributed in the central nervous system. Our previous study indicated that TFF3 was a potential rapid-onset antidepressant as it reversed the depressive-like behaviors induced by acute or chronic mild stress. In order ... | International journal of molecular sciences | 2,015 | 11 | 2 | 17 |
31,325,670 | Data-driven models in human neuroscience and neuroengineering. | Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer t... | Current opinion in neurobiology | 2,019 | 10 | 2 | 25 |
31,611,351 | Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa. | In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combination with an aminoglycoside, amikacin, against a polymyxin-susceptible isolate of | Antimicrobial agents and chemotherapy | 2,019 | 12 | 4 | 30 |
18,322,088 | Specificity of speech motor learning. | The idea that the brain controls movement using a neural representation of limb dynamics has been a dominant hypothesis in motor control research for well over a decade. Speech movements offer an unusual opportunity to test this proposal by means of an examination of transfer of learning between utterances that are to ... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,008 | 3 | 2 | 18 |
33,622,777 | Chronic Stress Prevents Cortico-Accumbens Cue Encoding and Alters Conditioned Approach. | Chronic stress impairs the function of multiple brain regions and causes severe hedonic and motivational deficits. One brain region known to be susceptible to these effects is the PFC. Neurons in this region, specifically neuronal projections from the prelimbic region (PL) to the nucleus accumbens core (NAcC), have a s... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,021 | 3 | 0 | 7 |
29,027,011 | Let's make microglia great again in neurodegenerative disorders. | All of the common neurodegenerative disorders-Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and prion diseases-are characterized by accumulation of misfolded proteins that trigger activation of microglia; brain-resident mononuclear phagocytes. This chronic form of neuroinflammation is earmarke... | Journal of neural transmission (Vienna, Austria : 1996) | 2,018 | 5 | 4 | 15 |
22,573,678 | Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation. | Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes by which these cross-linking or polyaminating enzymes participate broadly in neuronal death have ... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,012 | 5 | 3 | 18 |
26,983,977 | Rectus Pulley Displacements without Abnormal Oblique Contractility Explain Strabismus in Superior Oblique Palsy. | Using high-resolution magnetic resonance imaging (MRI), we investigated whether rectus pulleys are significantly displaced in superior oblique (SO) palsy and whether displacements account for strabismus patterns. | Ophthalmology | 2,016 | 6 | 3 | 21 |
25,598,429 | Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus. | Variations in early life maternal care modulate hippocampal development to program distinct emotional-cognitive phenotypes that persist into adulthood. Adult rat offspring that received low compared with high levels of maternal licking and grooming (low LG offspring) in early postnatal life show reduced long term poten... | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology | 2,015 | 6 | 4 | 18 |
29,370,825 | A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries. | Cognitive screeners are imperative for early diagnosis of dementia. The Visual Cognitive Assessment Test (VCAT) is a language-neutral, visual-based test which has proven useful for a multilingual population in a single-center study. However, its performance utility is unknown in a wider and more diverse Southeast Asian... | Alzheimer's research & therapy | 2,018 | 1 | 1 | 7 |
31,331,895 | Compact and Low-Power Neural Spike Compression Using Undercomplete Autoencoders. | Implantable microsystems that collect and transmit neural data are becoming very useful entities in the field of neuroscience. Limited by high data rates, on-chip compression is often required to transmit the recorded data without causing power dissipation at levels that would damage sensitive brain tissue. This paper ... | IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society | 2,019 | 8 | 1 | 20 |
24,891,493 | Stereovision and augmented reality for closed-loop control of grasping in hand prostheses. | Technologically advanced assistive devices are nowadays available to restore grasping, but effective and effortless control integrating both feed-forward (commands) and feedback (sensory information) is still missing. The goal of this work was to develop a user friendly interface for the semi-automatic and closed-loop ... | Journal of neural engineering | 2,014 | 8 | 3 | 36 |
18,638,542 | Impact of acute bisphenol-A exposure upon intrauterine implantation of fertilized ova and urinary levels of progesterone and 17beta-estradiol. | Bisphenol-A (BPA), a monomer used in production of polycarbonate plastics and epoxy resins, has established estrogenic properties. We assessed the impact of acute and repeated subcutaneous BPA administration upon intrauterine implantation of fertilized ova and urinary levels of 17beta-estradiol and progesterone in inse... | Reproductive toxicology (Elmsford, N.Y.) | 2,008 | 10 | 1 | 15 |
31,243,036 | Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group. | Survivors of critical illness frequently exhibit acute and chronic neurological complications. The underlying aetiology of this dysfunction remains unknown but may be associated with cerebral ischaemia. This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO | BMJ open | 2,019 | 6 | 0 | 4 |
22,450,232 | DeltaFosB is increased in the nucleus accumbens by amphetamine but not social housing or isolation in the prairie vole. | The nucleus accumbens is a key region that mediates aspects of immediate and long-term adaptations to various stimuli. For example, both repeated amphetamine and pair-bonding increase dopamine D1 receptor binding in the nucleus accumbens of the monogamous prairie vole (Microtus ochrogaster). This upregulation has signi... | Neuroscience | 2,012 | 5 | 2 | 4 |
26,994,483 | Testosterone reduces functional connectivity during the 'Reading the Mind in the Eyes' Test. | Women on average outperform men in cognitive-empathic abilities, such as the capacity to infer motives from the bodily cues of others, which is vital for effective social interaction. The steroid hormone testosterone is thought to play a role in this sexual dimorphism. Strikingly, a previous study shows that a single a... | Psychoneuroendocrinology | 2,016 | 6 | 3 | 33 |
20,357,105 | Early spatial attentional modulation of inputs to the fovea. | Attending to a specific spatial location modulates responsivity of neurons with receptive fields processing that part of the environment. A major outstanding question is whether attentional modulation operates differently for the foveal (central) representation of the visual field than it does for the periphery. Indeed... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,010 | 3 | 2 | 15 |
22,391,030 | Glutamate-based depression GBD. | We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over-activation of extrasynaptic NMDA receptors in the subgenual cingulate... | Medical hypotheses | 2,012 | 5 | 3 | 18 |
29,552,261 | Hyperacute unilateral contrast-induced parotiditis during cerebral angiography. | An uncommon complication of iodinated contrast administration is the development of bilateral sialadenitis. We report a unique case of hyperacute unilateral parotiditis during diagnostic cerebral angiography of the external carotid artery, which mimicked possible iatrogenic vascular event associated with cerebral endov... | Radiology case reports | 2,018 | 2 | 1 | 3 |
33,122,389 | State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia. | Understanding the effects of anesthesia on cortical neuronal spiking and information transfer could help illuminate the neuronal basis of the conscious state. Recent investigations suggest that the brain state identified by local field potential spectrum is not stationary but changes spontaneously at a fixed level of a... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,020 | 12 | 6 | 22 |
31,806,426 | Statin Use and Risk of Cognitive Decline in the ADNI Cohort. | To investigate associations between statin use and cognitive change, as well as diagnostic conversion, in individuals with cognitively normal (CN) status, mild cognitive impairment (MCI), and dementia due to Alzheimer disease (AD-dementia). | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2,020 | 5 | 4 | 13 |
19,824,934 | Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies. | Colorectal physiology is complex and involves programmed, coordinated interaction between muscular and neuronal elements. Whilst a detailed understanding remains elusive, novel information has emerged from recent basic science and human clinical studies concerning normal sensorimotor mechanisms and the organization and... | Neurogastroenterology and motility | 2,009 | 12 | 2 | 20 |
20,300,101 | Do astrocytes really exocytose neurotransmitters? | In the past 20 years, an extra layer of information processing, in addition to that provided by neurons, has been proposed for the CNS. Neuronally evoked increases of the intracellular calcium concentration in astrocytes have been suggested to trigger exocytotic release of the 'gliotransmitters' glutamate, ATP and D-se... | Nature reviews. Neuroscience | 2,010 | 4 | 26 | 267 |
30,267,847 | A new central post-stroke pain rat model: autologous blood injected thalamic hemorrhage involved increased expression of P2X4 receptor. | Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understa... | Neuroscience letters | 2,018 | 11 | 0 | 13 |
27,075,188 | Aspiration of parafalcine empyemas with flexible scope. | Subdural empyemas are considered neurosurgical emergencies, and the parafalcine location is particularly insidious. We revised the experience of general surgeons who are used to manage chronic pleural purulent collections with video-assisted thoracoscopy. | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | 2,016 | 6 | 0 | 2 |
21,556,793 | Projections from the rat pedunculopontine and laterodorsal tegmental nuclei to the anterior thalamus and ventral tegmental area arise from largely separate populations of neurons. | Cholinergic and non-cholinergic neurons in the brainstem pedunculopontine (PPT) and laterodorsal tegmental (LDT) nuclei innervate diverse forebrain structures. The cholinergic neurons within these regions send heavy projections to thalamic nuclei and provide modulatory input as well to midbrain dopamine cells in the ve... | Brain structure & function | 2,011 | 11 | 3 | 32 |
21,543,600 | Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. | Drug-induced changes in synaptic strength are hypothesized to contribute to appetitive behavior and addiction. Nicotine, the major addictive substance in tobacco, activates nicotinic receptors (nAChRs) to initiate a series of adaptive changes at the cellular and circuit levels in brain, particularly the ventral tegment... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,011 | 5 | 3 | 31 |
31,644,928 | The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. | Self-initiated action is critical to social interaction and individuals with social anxiety find it particularly difficult to initiate social interactions. We showed earlier that social exclusion encumbered self-initiated actions in the Cyberball task in young adults. Here, we examined whether the behavioral performanc... | Behavioural brain research | 2,020 | 1 | 1 | 5 |
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