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pmid int64 7.11M 40.4M	title stringlengths 1 553	abstract stringlengths 200 10.9k	journal stringlengths 3 239	pub_year int64 1.98k 2.02k	pub_month int64 1 12	citation_count_within_one_year int64 0 281	citation_count_within_five_years int64 0 1.17k
31,015,544	A novel wireless brain stimulation device for long-term use in freely moving mice.	Deep brain stimulation (DBS) has been used in clinical settings for many years despite a paucity of knowledge related to the anatomical and functional substrates that lead to benefits and/or side-effects in various disease contexts. In order to maximize the potential of this approach in humans, a better understanding o...	Scientific reports	2,019	4	0	8
27,153,125	Ecological momentary interventions in psychiatry.	In this review, we discuss feasibility, content, and where possible efficacy of ecological momentary interventions (EMIs) in psychiatry. EMIs adopt mobile devices, such as personal digital assistants or smartphones, for the delivery of treatments in the daily life of patients. We will discuss EMIs in the field of schiz...	Current opinion in psychiatry	2,016	7	2	75
23,748,408	Measuring motor coordination in mice.	Mice are increasingly being used in behavioral neuroscience, largely replacing rats as the behaviorist's animal of choice. Before aspects of behavior such as emotionality or cognition can be assessed, however, it is vital to determine whether the motor capabilities of e.g. a mutant or lesioned mouse allow such an asses...	Journal of visualized experiments : JoVE	2,013	5	1	46
28,988,523	Immunopathology in drug resistant mesial temporal lobe epilepsy with different types of hippocampal sclerosis.	There is evidence that autoimmunity has a specific role in temporal lobe seizures of limbic encephalitis patients. Our aim in this study was to investigate any histopathological clues of autoimmune process in refractory temporal lobe epilepsy (TLE) patients with different pathologically proven hippocampal sclerosis (HS...	The International journal of neuroscience	2,018	5	2	15
22,780,914	Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.	6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943) is a novel PDE9A inhibitor identified using parallel synthetic chemistry and structure-based drug design (SBDD) and has advanced into clinical trials. Selectivity for PDE...	Journal of medicinal chemistry	2,012	11	4	33
24,736,169	Neonatal EEG at scalp is focal and implies high skull conductivity in realistic neonatal head models.	The potential improvements in spatial resolution of neonatal EEG used in source localization have been challenged by the insufficiencies in realistic neonatal head models. Our present study aimed at using empirical methods to indirectly estimate skull conductivity; the model parameter that is known to significantly aff...	NeuroImage	2,014	8	0	26
32,353,951	The Length and Number of Sedentary Bouts Predict Fibrinogen Levels in Postmenopausal Women.	Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years...	International journal of environmental research and public health	2,020	4	3	12
26,214,729	N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization.	Treating infections caused by multidrug-resistant Gram-negative pathogens is challenging, and there is concern regarding the toxicity of the most effective antimicrobials for Gram-negative pathogens. We hypothesized that conjugating a fatty acid moiety onto a peptide dimer could maximize the interaction with lipopolysa...	Journal of medicinal chemistry	2,015	8	3	21
23,026,743	Neural dynamics and circuit mechanisms of decision-making.	In this review, I briefly summarize current neurobiological studies of decision-making that bear on two general themes. The first focuses on the nature of neural representation and dynamics in a decision circuit. Experimental and computational results suggest that ramping-to-threshold in the temporal domain and traject...	Current opinion in neurobiology	2,012	12	2	53
26,459,495	Occurrence of sickness absence and disability pension in relation to childbirth: A 16-year follow-up study of 6323 Swedish twins.	Pregnancy, delivery, and the postpartum period may imply morbidity leading to work incapacity; however, this is seldom studied. This study aimed to compare twin sisters giving or not giving birth regarding occurrence of sickness absence (SA) and disability pension (DP).	Scandinavian journal of public health	2,016	2	0	6
21,876,530	Lateral fluid percussion: model of traumatic brain injury in mice.	Traumatic brain injury (TBI) research has attained renewed momentum due to the increasing awareness of head injuries, which result in morbidity and mortality. Based on the nature of primary injury following TBI, complex and heterogeneous secondary consequences result, which are followed by regenerative processes (1,2)....	Journal of visualized experiments : JoVE	2,011	8	0	21
30,308,256	Recent progress of drug nanoformulations targeting to brain.	Most of the potential therapeutic agents capable to modulate the pathophysiology or treat the neurological disorders and brain tumors are useless in the current modern and advanced era of neuroscience due to the impeding action of biological barriers. Among various therapeutic strategies applied for translocation of dr...	Journal of controlled release : official journal of the Controlled Release Society	2,018	12	14	119
30,174,118	Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.	Astrocytes tile the central nervous system, but their functions in neural microcircuits in vivo and their roles in mammalian behavior remain incompletely defined. We used two-photon laser scanning microscopy, electrophysiology, MINIscopes, RNA-seq, and a genetic approach to explore the effects of reduced striatal astro...	Neuron	2,018	9	18	206
32,710,334	Effects of emotional maltreatment on semantic network activity during cognitive reappraisal.	Maltreatment experiences alter brain development associated with emotion processing, and dysregulation of emotion may trigger mental health problems in maltreated people. However, studies revealing alterations in brain networks during cognitive reappraisal in victims of maltreatment are strikingly insufficient. In this...	Brain imaging and behavior	2,021	6	2	9
27,137,838	Reciprocal interactions between circadian clocks and aging.	Virtually, all biological processes in the body are modulated by an internal circadian clock which optimizes physiological and behavioral performance according to the changing demands of the external 24-h world. This circadian clock undergoes a number of age-related changes, at both the physiological and molecular leve...	Mammalian genome : official journal of the International Mammalian Genome Society	2,016	8	8	47
32,589,613	Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.	More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.A randomized controlled clinical trial randomized 63 healthy adults (...	Aging	2,020	6	2	34
26,219,430	Alcohol dependence and treatment utilization in Europe - a representative cross-sectional study in primary care.	Alcohol dependence (AD) in Europe is prevalent and causes considerable health burden. Recognition by general practitioners (GPs) and provision of or referral to treatment may contribute to reduce this burden. This paper studied AD prevalence in varying European primary care settings and examined who received treatment.	BMC family practice	2,015	7	6	48
28,807,787	Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats.	Sites and mechanisms by which trigeminal nerve stimulation (TNS) exerts beneficial effects on symptoms of drug-resistant epilepsy and depression are still unknown. Effects of short-term TNS on brain regions involved in the physiopathology of these disorders were investigated in this study. Forty male rats were assigned...	Neuroscience	2,017	10	3	20
26,920,756	σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila.	The functional requirement of adapter protein 2 (AP2) complex in synaptic membrane retrieval by clathrin-mediated endocytosis is not fully understood. Here we isolated and functionally characterized a mutation that dramatically altered synaptic development. Based on the aberrant neuromuscular junction (NMJ) synapse, we...	Genetics	2,016	5	2	7
26,251,434	Accuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers.	The arterial spin-labeling method for CBF assessment is widely available, but its accuracy is not fully established. We investigated the accuracy of a whole-brain arterial spin-labeling technique for assessing the mean parenchymal CBF and the effect of aging in healthy volunteers. Phase-contrast MR imaging was used as ...	AJNR. American journal of neuroradiology	2,015	10	1	10
22,287,383	The need for complex ideas in anorexia nervosa: why biology, environment, and psyche all matter, why therapists make mistakes, and why clinical benchmarks are needed for managing weight correction.	Anorexia nervosa remains an enigma and its clinical challenge is intimidating. But the potential for new insights has been advancing, largely as a result of elegant research in the neurosciences that has modeled behavioral processes resembling key features of the illness. Unfortunately, many in the eating disorder fiel...	The International journal of eating disorders	2,012	3	4	41
23,303,955	The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).	The Neural cell adhesion molecule (NCAM) plays an important role in regulation of nervous system development. To expand our understanding of the molecular mechanisms via which NCAM influences differentiation of neurons, we used a yeast two-hybrid screening to search for new binding partners of NCAM and identified p21-a...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,013	1	2	20
25,845,030	Solvent accessible surface area-based hot-spot detection methods for protein-protein and protein-nucleic acid interfaces.	Due to the importance of hot-spots (HS) detection and the efficiency of computational methodologies, several HS detecting approaches have been developed. The current paper presents new models to predict HS for protein-protein and protein-nucleic acid interactions with better statistics compared with the ones currently ...	Journal of chemical information and modeling	2,015	5	3	15
26,429,678	Psychiatric classification - a developmental perspective.	Current classification systems treat developmental and adult psychopathologies as separate. However, as risk factors for psychiatric disorders are identified it is increasingly clear that these can lead to multiple outcomes across different developmental stages. Research and classification schemes will therefore in the...	The British journal of psychiatry : the journal of mental science	2,015	10	0	7
28,532,381	Visuomotor Functions in the Frontal Lobe.	This review surveys how vision becomes action through the frontal lobe. Signals from extrastriate areas create maps in frontal areas. These maps are shaped by visual features and shaded by goals, values, and experience, and they guide contingent activation of motor circuits to execute coordinated gaze, head, and limb m...	Annual review of vision science	2,015	11	4	43
30,916,810	Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.	Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the ...	Journal of neuroscience research	2,019	12	1	4
33,349,698	An open letter to past, current and future mentors of Black neuroscientists.	We as Black trainees in neuroscience and co-founders of Black In Neuro wrote this open letter to thank the phenomenal mentors who came before us. We also aim to encourage and give advice to future mentors on how to effectively mentor the next generation of Black researchers.	Nature reviews. Neuroscience	2,021	2	5	12
25,980,363	ato-Gal4 fly lines for gene function analysis: Eya is required in late progenitors for eye morphogenesis.	The Gal4/UAS system is one of the most powerful tools for the study of cellular and developmental processes in Drosophila. Gal4 drivers can be used to induce targeted expression of dominant-negative and dominant-active proteins, histological markers, activity sensors, gene-specific dsRNAs, modulators of cell survival o...	Genesis (New York, N.Y. : 2000)	2,015	6	0	2
22,745,490	Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression.	Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of fu...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,012	6	12	179
22,634,505	Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease.	Evidence from clinical and experimental studies indicates that degeneration of nigrostriatal dopaminergic neurons is a pathological hallmark of Parkinson's disease (PD). The present study was designed to investigate the neuroprotective potential of theaflavin (TF) on oxidative stress, monoamine transporters and behavio...	Neuroscience	2,012	8	3	22
29,966,850	Adverse effects of GHB-induced coma on long-term memory and related brain function.	Gamma-Hydroxybutyric acid (GHB) is a drug of abuse associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced coma. Animal studies suggest that GHB induces oxidative stress in the hippocampus, resulting in memory impairments. However, the consequences of chronic ...	Drug and alcohol dependence	2,018	9	3	16
23,815,670	The dimerization domain in outer segment guanylate cyclase is a Ca²⁺-sensitive control switch module.	Membrane-bound guanylate cyclases harbor a region called the dimerization or linker domain, which aids the enzymes in adopting an optimal monomer-monomer arrangement for catalysis. One subgroup of these guanylate cyclases is expressed in rod and cone cells of vertebrate retina, and mutations in the dimerization domain ...	Biochemistry	2,013	7	1	16
27,172,792	Identifying and targeting determinants of melanoma cellular invasion.	Epithelial-to-mesenchymal transition is a critical process that increases the malignant potential of melanoma by facilitating invasion and dissemination of tumor cells. This study identified genes involved in the regulation of cellular invasion and evaluated whether they can be targeted to inhibit melanoma invasion. We...	Oncotarget	2,016	7	1	20
22,564,741	The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.	Embryonic neural stem cells (NSCs) exhibit self-renewal and multipotency as intrinsic characteristics that are key parameters for proper brain development. When cells are challenged by oxidative stress agents the resulting DNA lesions are repaired by DNA glycosylases through the base excision repair (BER) pathway as a ...	Biochemical and biophysical research communications	2,012	7	4	10
24,948,399	Epigenetic regulation of persistent pain.	Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic reg...	Translational research : the journal of laboratory and clinical medicine	2,015	1	6	40
26,505,566	Measuring macroscopic brain connections in vivo.	Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensiti...	Nature neuroscience	2,015	11	22	193
25,185,809	A functional circuit model of interaural time difference processing.	Inputs from the two sides of the brain interact to create maps of interaural time difference (ITD) in the nucleus laminaris of birds. How inputs from each side are matched with high temporal precision in ITD-sensitive circuits is unknown, given the differences in input path lengths from each side. To understand this pr...	Journal of neurophysiology	2,014	12	5	10
26,853,734	Additive effect of BLA GABAA receptor mechanism and (+)-MK-801 on memory retention deficit, an isobologram analysis.	There is a near correlation between N-methyl-d-aspartate (NMDA) and γ-aminobutyric acid (GABA) receptors in the modulation of learning and memory in the basolateral amygdala (BLA). In this study, we investigated the involvement of GABAA receptors in the BLA in amnesia induced by (+)-MK-801, a noncompetitive antagonist ...	Pharmacology, biochemistry, and behavior	2,016	4	0	4
28,801,917	Attention-Deficit/Hyperactivity Disorder (ADHD): Interaction between socioeconomic status and parental history of ADHD determines prevalence.	Many studies have reported a higher prevalence of Attention-Deficit/Hyperactivity Disorder (ADHD) among disadvantaged populations, but few have considered how parental history of ADHD might modify that relationship. We evaluated whether the prevalence of ADHD varies by socioeconomic status (SES) and parental history of...	Journal of child psychology and psychiatry, and allied disciplines	2,018	3	3	37
29,373,439	Psychological Factors and Outcomes in the Surgical Treatment of Pediatric Patients With Median Arcuate Ligament Syndrome.	Median arcuate ligament syndrome (MALS) is a frequently overlooked cause of chronic abdominal pain (CAP), and results in many symptoms that mimic other gastrointestinal conditions that result in CAP. A small, but growing body of literature indicates that surgery improves quality of life (QOL) in patients with MALS. The...	Journal of pediatric gastroenterology and nutrition	2,018	6	1	8
27,161,524	DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor.	Transplantation of DA neurons is actively pursued as a restorative therapy in Parkinson's disease (PD). Pioneering clinical trials using transplants of fetal DA neuroblasts have given promising results, although a number of patients have developed graft-induced dyskinesias (GIDs), and the mechanism underlying this trou...	Neuron	2,016	6	4	33
21,309,750	The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.	The non-RTK (receptor tyrosine kinase) ACK1 [activated Cdc42 (cell division cycle 42)-associated kinase 1] binds a number of RTKs and is associated with their endocytosis and turnover. Its mode of activation is not well established, but models have suggested that this is an autoinhibited kinase. Point mutations in its ...	The Biochemical journal	2,011	4	0	11
20,637,543	Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain.	Descending modulation of nociceptive transmission depends on the release of noradrenaline at the spinal cord. The role of noradrenaline in the control of nociceptive transmission at the supraspinal pain control system remains understudied. As chronic pain is associated with enhanced descending facilitation of nocicepti...	Pain	2,010	10	5	24
27,197,831	Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy.	Increased male susceptibility to long-term cognitive deficits is well described in clinical and experimental studies of neonatal hypoxic-ischemic encephalopathy. While cell death signaling pathways are known to be sexually dimorphic, a sex-dependent pathophysiological mechanism preceding the majority of secondary cell ...	Journal of neurochemistry	2,016	6	10	50
32,585,130	Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1.	An understanding of the structure-dynamics relationship is essential for understanding how a protein works. Prior research has shown that the activity of a protein correlates with intradomain dynamics occurring at picosecond to millisecond timescales. However, the correlation between interdomain dynamics and the functi...	Biophysical journal	2,020	7	4	12
22,588,670	Secular changes in personality: study on 75-year-olds examined in 1976-1977 and 2005-2006.	In order to study secular changes in personality factors neuroticism and extroversion, representative population samples of non-demented 75-year-olds underwent psychiatric examinations in 1976-1977 (total n = 223, 138 women, 85 men) and 2005-2006 (total n = 556, 322 women and 234 men).	International journal of geriatric psychiatry	2,013	3	2	7
22,171,033	Active action potential propagation but not initiation in thalamic interneuron dendrites.	Inhibitory interneurons of the dorsal lateral geniculate nucleus of the thalamus modulate the activity of thalamocortical cells in response to excitatory input through the release of inhibitory neurotransmitter from both axons and dendrites. The exact mechanisms by which release can occur from dendrites are, however, n...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,011	12	2	21
27,976,689	The proteomic profile of whole and glandular saliva in healthy pain-free subjects.	Determination of the variability in the salivary proteome is a prerequisite for the development of saliva as a diagnostic and prognostic tool in particular physiological states. In this context, it is important that technical variability induced by sample collection and processing is kept at minimum to be able to repro...	Scientific reports	2,016	12	2	42
25,700,195	Mentoring the next generation of neuroscience nurses: a pilot study of mentor engagement within an academic-service partnership.	Resulting from a system-wide launch of an academic-service partnership that united a research-intensive School of Nursing and a tertiary healthcare system, neuroscience nurses used a team-based approach in mentoring undergraduate nursing students in neuroscience nursing. They linked their team approach to the Institute...	The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses	2,015	4	0	1
33,947,543	Radio-sensitivity enhancement in HT29 cells through magnetic hyperthermia in combination with targeted nano-carrier of 5-Flourouracil.	Normal tissue complication and development of radioresistance in cancer cells are known as the main challenges of ionizing radiation treatment. In the current study, we intended to induce selective radiosensitization in HT29 cancer cells by developing folic acid modified magnetic triblock copolymer nanoparticles as car...	Materials science & engineering. C, Materials for biological applications	2,021	5	3	17
27,283,589	Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats.	Androgen loss is an important clinical concern because of its cognitive and behavioral effects. Changes in androgen levels are also suspected to contribute to neurological disease. However, the available data on the effects of androgen deprivation in areas of the brain that are central to cognition, like the hippocampu...	Brain structure & function	2,017	1	1	19
32,782,247	Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis.	The central role played by cerebrospinal-fluid (CSF) examinations including antineuronal autoantibody (Ab) testing is increasingly recognized in psychiatry. The rationale of this study was to present a multimodally investigated group of patients. In total, 992 patients were analyzed for CSF alterations: 456 patients wi...	Translational psychiatry	2,020	8	11	63
26,162,240	Effects of acoustic trauma on the auditory system of the rat: The role of microglia.	Exposure to loud, prolonged sounds (acoustic trauma, AT) leads to the death of both inner and outer hair cells (IHCs and OHCs), death of neurons of the spiral ganglion and degeneration of the auditory nerve. The auditory nerve (8cn) projects to the three subdivisions of the cochlear nuclei (CN), the dorsal cochlear nuc...	Neuroscience	2,015	9	0	19
23,924,992	C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity.	The transcripts of L-type voltage-gated calcium channels (CaV) 1.3 undergo extensive alternative splicing. Alternative splicing, particularly in the C terminus, drastically modifies gating properties of the channel. However, little is known about whether alternative splicing could modulate the pharmacologic properties ...	Molecular pharmacology	2,013	10	3	22
31,732,108	Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder.	Approximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of induced pluripotent stem cell methodology enabled better modeling of this disorder.	Biological psychiatry	2,020	7	8	47
25,979,487	Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.	Neuropeptide S (NPS) regulates various biological functions by selectively activating the NPS receptor (NPSR). In particular NPS evokes robust anxiolytic-like effects in rodents together with a stimulant and arousal promoting action. The aim of the study was to investigate the effects of NPS on the aggressiveness of mi...	Neuropharmacology	2,015	10	1	11
26,469,048	Progress and challenges in probing the human brain.	Perhaps one of the greatest scientific challenges is to understand the human brain. Here we review current methods in human neuroscience, highlighting the ways that they have been used to study the neural bases of the human mind. We begin with a consideration of different levels of description relevant to human neurosc...	Nature	2,015	10	11	127
23,706,187	The central circadian timing system.	It has been known since the 1970s that the suprachiasmatic nucleus (SCN) is the brain's main biological clock, and since the 1990s that it uses a genetic clock based on transcriptional-translational loops to tell time. However, the recent demonstration that many other cells in the brain and the body also make use of th...	Current opinion in neurobiology	2,013	10	7	43
26,838,118	Concurrent Risperidone Administration Attenuates the Development of Locomotor Sensitization Following Sub-Chronic Phencyclidine in Rats.	In schizophrenia early treatment may prevent disorder onset, or at least minimize its impact, suggesting possible neuroprotective properties of antipsychotics. The present study investigates the effects of chronic treatment with the atypical antipsychotic, risperidone, on locomotor sensitization in the subchronic phenc...	Pharmacopsychiatry	2,016	3	0	1
26,272,028	A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis.	Cortical grey matter (GM) lesions are common in multiple sclerosis (MS), but little is known about their temporal evolution. We investigated this in people with relapsing-remitting (RR) and secondary progressive (SP) MS.	Journal of neurology, neurosurgery, and psychiatry	2,016	7	2	9
23,283,340	Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.	Intracellular Ca(2+) signals control the development and regeneration of spinal axons downstream of chemical guidance cues, but little is known about the roles of mechanical cues in axon guidance. Here we show that transient receptor potential canonical 1 (TRPC1) subunits assemble mechanosensitive (MS) channels on Xeno...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,013	1	7	41
18,418,782	Severity of nicotine dependence moderates performance on perceptual-motor tests of attention.	Acute abstinence from cigarette smoking by nicotine-dependent smokers has been linked with cognitive deficits, but the role of nicotine dependence per se in these effects is not known. We therefore tested the relationships of nicotine dependence and smoking history with performance in perceptual-motor, timed tests of a...	Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco	2,008	4	0	7
29,199,893	Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?	Nanomedicines allow for the delivery of small interfering RNAs (siRNAs) that are otherwise barely suitable as therapeutics for inducing RNA interference (RNAi). In preclinical studies on siRNA-based glioma treatment in vivo, various groups of nanoparticle systems, routes of administration and target genes have been exp...	Nanomedicine (London, England)	2,018	1	1	23
22,245,502	Naloxone in ultralow concentration restores endomorphin-1-evoked Ca²⁺ signaling in lipopolysaccharide pretreated astrocytes.	Long-term pain is a disabling condition that affects thousands of people. Pain may be sustained for a long time even after the physiological trigger has resolved. Possible mechanisms for this phenomenon include low-grade inflammation in the CNS. Astrocytes respond to inflammatory stimuli and may play an important role ...	Neuroscience	2,012	3	0	13
28,820,427	A Review of the Neuropsychological Dimensions of Tourette Syndrome.	Neurocognitive functioning in Tourette syndrome (TS) has been the subject of intensive research in the past 30 years. A variety of impairments, presumably related to frontal and frontostriatal dysfunctions, have been observed. These impairments were found in various domains, such as attention, memory, executive functio...	Brain sciences	2,017	8	3	26
33,921,465	MicroRNAs in Basolateral Amygdala Associated with Stress and Fear Memories Regulate Rapid Eye Movement Sleep in Rats.	Stress-related sleep disturbances are distressing clinical symptoms in posttraumatic stress disorder patients. Intensely stressful events and their memories change rapid eye movement (REM) sleep in animal models. REM sleep varies with individual differences of stress resilience or vulnerability. The basolateral amygdal...	Brain sciences	2,021	4	0	3
19,229,522	The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats.	We previously showed that systemic administration of the prototypical alpha-2 noradrenaline (NA) receptor antagonist yohimbine increases alcohol self-administration and reinstatement. Yohimbine also acts as an agonist of 5-hydroxytryptamine (5-HT) 5-HT1A receptors, which have been shown to be involved in alcohol seekin...	Psychopharmacology	2,009	6	5	30
24,965,042	Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease.	Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), shows multiple pharmacological actions such as inhibiting presynaptic α2 noradrenaline receptor (NAR) and selectively activating 5-hydroxytriptamine (5-HT) 1A receptor (5-HT1AR). Mirtazapine was also reported to increase dopamine release in ...	BMC neuroscience	2,014	6	2	9
31,202,956	French clinical guidelines for peripheral motor nerve blocks in a PRM setting.	Motor nerve blocks with anesthetic drug for local anesthesia are commonly used in physical and rehabilitation medicine (PRM), especially in the field of spasticity. Guidelines in this context are currently lacking.	Annals of physical and rehabilitation medicine	2,019	7	0	21
29,298,861	Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish.	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent organic pollutant (POP), an unintentional byproduct of various industrial processes, and a human carcinogen. The expression of the cytochrome P450 1A (cyp1a) gene is upregulated in the presence of TCDD through activating the aryl hydrocarbon receptor pathway in...	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2,018	5	2	9
20,626,877	An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector.	This study compared the transduction efficiencies of an adeno-associated viral (AAV) vector, which was pseudotyped with an AAV1 capsid and encoded the green fluorescent protein (GFP), with a lentiviral (LV) vector, which was pseudotyped with a VSV-G envelop and encoded the discosoma red fluorescent protein (dsRed), to ...	BMC neuroscience	2,010	7	0	7
33,255,402	Improving Dignity of Care in Community-Dwelling Elderly Patients with Cognitive Decline and Their Caregivers. The Role of Dignity Therapy.	Demographic changes have placed age-related mental health disorders at the forefront of public health challenges over the next three decades worldwide. Within the context of cognitive impairment and neurocognitive disorders among elderly people, the fragmentation of the self is associated with existential suffering, lo...	Behavioral sciences (Basel, Switzerland)	2,020	11	3	11
25,687,761	Small angle X-ray scattering analysis of Cu(2+)-induced oligomers of the Alzheimer's amyloid β peptide.	Research into causes of Alzheimer's disease and its treatment has produced a tantalising array of hypotheses about the role of transition metal dyshomeostasis, many of them on the interaction of these metals with the neurotoxic amyloid-β peptide (Aβ). Here, we have used small angle X-ray scattering (SAXS) to study the ...	Metallomics : integrated biometal science	2,015	3	0	13
25,880,443	Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.	Fatal familial insomnia (FFI) and a genetic form of Creutzfeldt-Jakob disease (CJD178) are clinically different prion disorders linked to the D178N prion protein (PrP) mutation. The disease phenotype is determined by the 129 M/V polymorphism on the mutant allele, which is thought to influence D178N PrP misfolding, lead...	PLoS pathogens	2,015	4	6	37
18,795,266	Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.	Positive allosteric modulators of the glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptor do not stimulate AMPA receptors directly but delay deactivation of the receptor and/or slow its desensitisation. This results in increased synaptic responses and enhanced long-term potentiation. T...	Psychopharmacology	2,009	1	3	19
27,775,225	Characterization of Phenotypic and Transcriptional Differences in Human Pluripotent Stem Cells under 2D and 3D Culture Conditions.	Human pluripotent stem cells hold great promise for applications in drug discovery and regenerative medicine. Microfluidic technology is a promising approach for creating artificial microenvironments; however, although a proper 3D microenvironment is required to achieve robust control of cellular phenotypes, most curre...	Advanced healthcare materials	2,016	11	2	19
33,542,304	The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche.	Smart biomaterials are increasingly being used to control stem cell fate in vitro by the recapitulation of the native niche microenvironment. By integrating experimental measurements with numerical models, we show that in mesenchymal stem cells grown inside a 3D synthetic niche both nuclear transport of a myogenic fact...	Scientific reports	2,021	2	3	13
21,106,827	Retrieval of associative information congruent with prior knowledge is related to increased medial prefrontal activity and connectivity.	We remember information that is congruent instead of incongruent with prior knowledge better, but the underlying neural mechanisms related to this enhancement are still relatively unknown. Recently, this memory enhancement due to a prior schema has been suggested to be based on rapid neocortical assimilation of new inf...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,010	11	3	44
29,909,983	Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features.	Transcription factors regulate the molecular, morphological, and physiological characteristics of neurons and generate their impressive cell-type diversity. To gain insight into the general principles that govern how transcription factors regulate cell-type diversity, we used large-scale single-cell RNA sequencing to c...	Cell	2,018	7	21	164
26,001,638	The transfer function of neuron spike.	The mathematical modeling of neuronal signals is a relevant problem in neuroscience. The complexity of the neuron behavior, however, makes this problem a particularly difficult task. Here, we propose a discrete-time linear time-invariant (LTI) model with a rational function in order to represent the neuronal spike dete...	Neural networks : the official journal of the International Neural Network Society	2,015	8	0	2
24,183,013	The neuron identity problem: form meets function.	A complete understanding of nervous system function cannot be achieved without the identification of its component cell types. In this Perspective, we explore a series of related issues surrounding cell identity and how revolutionary methods for labeling and probing specific neuronal types have clarified this question....	Neuron	2,013	10	9	57
33,612,000	The gender-binary cycle: the perpetual relations between a biological-essentialist view of gender, gender ideology, and gender-labelling and sorting.	Gender inequality is one of the most pressing issues of our time. A core factor that feeds gender inequality is people's gender ideology-a set of beliefs about the proper order of society in terms of the roles women and men should fill. We argue that gender ideology is shaped, in large parts, by the way people make sen...	Philosophical transactions of the Royal Society of London. Series B, Biological sciences	2,021	4	11	33
32,030,781	Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus.	Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary withholding of a drug in a situation of clinical need. The aim of this study was to develop consensus...	Journal of inherited metabolic disease	2,020	7	8	43
30,149,333	Depression and chronic diseases: Co-occurrence and communality of risk factors.	The aim of current study is to assess the cross-sectional association of chronic non-communicable diseases (diabetes mellitus, arthritis, asthma, chronic lung disease, angina, and stroke) with both diagnosed and undiagnosed depression in the World Health Organization (WHO) Study on global AGEing and adult health (SAGE)...	Journal of affective disorders	2,018	12	10	81
29,266,810	Multimodal approaches to functional connectivity in autism spectrum disorders: An integrative perspective.	Atypical functional connectivity has been implicated in autism spectrum disorders (ASDs). However, the literature to date has been largely inconsistent, with mixed and conflicting reports of hypo- and hyper-connectivity. These discrepancies are partly due to differences between various neuroimaging modalities. Function...	Developmental neurobiology	2,018	5	12	37
20,713,562	Ten years of chronic cluster--attacks still cluster.	The chronic variant can be found in 10-20% of all cluster headache patients. While circadian and circannual rhythmicity are characteristic of the episodic variant, little is known on chronobiology in chronic cluster headache. We report a patient with chronic cluster evolved from episodic who recorded a total of 5447 at...	Cephalalgia : an international journal of headache	2,010	9	0	4
32,034,695	Nickel-Induced Developmental Neurotoxicity in C. elegans Includes Cholinergic, Dopaminergic and GABAergic Degeneration, Altered Behaviour, and Increased SKN-1 Activity.	Nickel (Ni) is a ubiquitous metal in the environment with increasing industrial application. While environmental and occupational exposure to Ni compounds has been known to result in toxicities to several organs, including the liver, kidney, lungs, skin and gonads, neurotoxic effects have not been extensively investiga...	Neurotoxicity research	2,020	4	9	46
19,521,663	Depression and antidepressants: molecular and cellular aspects.	Clinical depression is viewed as a physical and psychic disease process having a neuropathological basis, although a clear understanding of its ethiopathology is still missing. The observation that depressive symptoms are influenced by pharmacological manipulation of monoamines led to the hypothesis that depression res...	Cellular and molecular life sciences : CMLS	2,009	9	3	32
28,770,403	Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.	Post-stroke dysphagia is common, associated with poor outcome and often requires non-oral feeding/fluids. The relationship between route of feeding and outcome, as well as treatment with glyceryl trinitrate (GTN), was studied prospectively. The Efficacy of Nitric Oxide in Stroke (ENOS) trial assessed transdermal GTN (5...	Translational stroke research	2,018	4	0	6
31,570,534	Toward Robust Functional Neuroimaging Genetics of Cognition.	A commonly held assumption in cognitive neuroscience is that, because measures of human brain function are closer to underlying biology than distal indices of behavior/cognition, they hold more promise for uncovering genetic pathways. Supporting this view is an influential fMRI-based study of sentence reading/listening...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,019	10	4	14
27,989,963	Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome.	Chronic inflammation is currently recognized as a critical process in modern-era epidemics such as diabetes, obesity and neurodegeneration. However, little attention is paid to the constitutive inflammatory pathways that operate in the gut and that are mandatory for local welfare and the prevention of such multi-organi...	The international journal of biochemistry & cell biology	2,016	12	0	5
30,347,373	Dioxins as potential risk factors for autism spectrum disorder.	Autism spectrum disorder (ASD) has emerged as a major public health concern due to its fast-growing prevalence in recent decades. Environmental factors are thought to contribute substantially to the variance in ASD. Interest in environmental toxins as causes of ASD has arisen due to the high sensitivity of the developi...	Environment international	2,018	12	5	20
30,509,565	Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1.	Liver kinase B1 (LKB1), a downstream effector of cyclic AMP (cAMP)/PKA and phosphatidylinositol 3-kinase (PI3K) pathways, is a determinant for migration and differentiation of many cells, but its role in CNS axon regeneration is unknown. Therefore, LKB1 was overexpressed in sensorimotor cortex of adult mice five days a...	Molecular therapy : the journal of the American Society of Gene Therapy	2,019	1	3	25
21,084,613	Lower-frequency event-related desynchronization: a signature of late mismatch responses to sounds, which is reduced or absent in children with specific language impairment.	Poor discrimination of nonlinguistic sounds has been implicated in language-learning problems in children, but research evidence has been inconsistent. This study included 32 participants with specific language impairment (SLI) and 32 typically developing controls aged 7-16 years. Frequency discrimination thresholds we...	The Journal of neuroscience : the official journal of the Society for Neuroscience	2,010	11	1	18
27,074,574	Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.	We investigated whether platelets prime colon cancer cells for metastasis and whether pharmacological inhibition of platelet function may prevent it. Coculturing HT29 human colon carcinoma cells with human platelets led to the induction of mesenchymal-like cancer cells characterized by downregulation of E-cadherin and ...	Oncotarget	2,016	5	13	89
18,287,950	Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model.	Pharmacological activation of group III metabotropic glutamate receptors (mGluR) or inhibition of group I mGluR by subtype-selective ligands is neuroprotective in experimental models of Parkinson's disease. The aim of this study was to investigate whether targeting both receptor subtypes simultaneously produces enhance...	Neuroreport	2,008	3	0	13
29,292,502	Validated multi-step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus.	Precise quantification of extracellular glutamate concentrations upon neuronal activation is crucial for the understanding of brain function and neurological disorders. While optogenetics is an outstanding method for the correlation between distinct neurons and their role in circuitry and behavior, the electrochemicall...	Journal of neurochemistry	2,018	4	0	10
33,750,832	Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains.	To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of non-shivering thermogenesis. We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (f...	Scientific reports	2,021	3	5	12
33,807,308	Initial Experience of the Levodopa-Entacapone-Carbidopa Intestinal Gel in Clinical Practice.	Patients in fluctuating stages of Parkinson's disease (PD) require device-aided treatments. Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) is a well-proven option in clinical practice. We now report the first clinical experience of levodopa-entacapone-carbidopa intestinal gel (LECIG) therapy. An observ...	Journal of personalized medicine	2,021	3	7	40
28,892,581	Direct current stimulation modulates the excitability of the sensory and motor fibres in the human posterior tibial nerve, with a long-lasting effect on the H-reflex.	Several studies demonstrated that transcutaneous direct current stimulation (DCS) may modulate central nervous system excitability. However, much less is known about how DC affects peripheral nerve fibres. We investigated the action of DCS on motor and sensory fibres of the human posterior tibial nerve, with supplement...	The European journal of neuroscience	2,017	11	2	19

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Dataset Card for PubMed Citations Dataset

Dataset Description

This dataset contains metadata and citation information for 20,000 neuroscience-related articles indexed by PubMed. The data is intended for tasks related to bibliometrics, scientific impact prediction, citation analysis, and natural language processing on biomedical literature.

Half of the articles have been cited within the first five years following publication, the other half has not.

Dataset Structure

Format: CSV
Rows: 20,000 entries
Columns: 8

Column Name	Description	Type
`pmid`	PubMed ID (unique identifier for each article)	int64
`title`	Title of the article	string
`abstract`	Abstract text of the article	string
`journal`	Journal where the article was published	string
`pub_year`	Year of publication	int64
`pub_month`	Month of publication	int64
`citation_count_within_one_year`	Number of citations within 1 year of publication (from OpenCitations API)	float64
`citation_count_within_five_years`	Number of citations within 5 years of publication (from OpenCitations API)	float64

Example Entry

{
  "pmid": 27466332,
  "title": "Catecholaminergic Neuromodulation Shapes Intrinsic MRI Functional Connectivity in the Human Brain",
  "abstract": "The brain commonly exhibits spontaneous (i.e.,...",
  "journal": "The Journal of neuroscience",
  "pub_year": 2016,
  "pub_month": 7,
  "citation_count_within_one_year": 8.0,
  "citation_count_within_five_years": 51.0
}

Source Data

Original source: PubMed
Citation counts: Retrieved via OpenCitations API
License: Please check terms of use for PubMed and OpenCitations before redistribution.

Intended Uses

Predicting citation count based on article metadata and abstract.
Studying the relationship between article content and citation patterns.
Benchmarking NLP models on biomedical abstracts.

Dataset Creation

Articles were sampled from PubMed.
Citation counts were collected using the OpenCitations API for each pmid.
Data was cleaned to ensure all entries have complete fields.

Data Splits

No predefined splits. Users may create splits (e.g., train/test/validation) as needed.

Usage Example (Python/Huggingface Datasets)

from datasets import load_dataset
dataset = load_dataset(
    "rudyvdbrink/CitationDatabase", 
    data_files="NeuroscienceCitationDatabase.json",
)

Limitations

Only includes articles with complete metadata and citation data.
Citation data is as provided by OpenCitations; coverage may not be exhaustive.
Abstracts may contain formatting artifacts.

Citation

If you use this dataset, please cite the authors of the articles appropriately.

Contact

brinkdatascience.com

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