pmid int64 7.11M 40.4M | title stringlengths 1 553 | abstract stringlengths 200 10.9k | journal stringlengths 3 239 | pub_year int64 1.98k 2.02k | pub_month int64 1 12 | citation_count_within_one_year int64 0 281 | citation_count_within_five_years int64 0 1.17k |
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33,583,347 | The effects of the activation of hostile and non-hostile schemas on intent attribution processes in non-aggressive individuals: An ERP study. | We investigated the influences of hostile and non-hostile schemas activations in non-aggressive individuals on their intent attribution processes in various social contexts. 38 non-aggressive participants were randomly assigned to one of two groups, one primed with negative words, to be conditioned as temporarily hosti... | Social neuroscience | 2,021 | 4 | 0 | 0 |
30,243,037 | Sensitivity to pain expectations: A Bayesian model of individual differences. | The thoughts and feelings people have about pain (referred to as 'pain expectations') are known to alter the perception of pain. However little is known about the cognitive processes that underpin pain expectations, or what drives the differing effect that pain expectations have between individuals. This paper details ... | Cognition | 2,019 | 1 | 0 | 0 |
32,622,019 | Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core. | Nuclear pore complex (NPC) is a gating nanomachine with a central selective barrier composed mainly of Nups, which contain intrinsically disordered (non-structured) regions (IDRs) with phenylalanine-glycine (FG) motifs (FG-NUPs). The NPC central FG network dynamics is poorly understood, as FG-NUPs liquid-liquid phase s... | Biomaterials | 2,020 | 10 | 0 | 0 |
32,891,686 | Role of orexin receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of inflammatory pain. | Pain is a complex experience consisting of sensory, affective-motivational, and cognitive dimensions. Hence, identifying the multiple neural pathways subserving these functional aspects is a valuable task. The role of dentate gyrus (DG) as a relay station of neocortical afferents in the hippocampal formation (HF) in pe... | Peptides | 2,020 | 12 | 0 | 0 |
32,657,247 | Arterial spin labeling-MR may be an alternative to SPECT for evaluating cerebral perfusion in patients with unilateral middle cerebral artery stenosis. | Cerebral blood flow (CBF) mapping of single-photon emission tomography (SPECT) is considered a gold standard for evaluating cerebral perfusion. However, invasiveness, high costs and strict technical requirements can limit its clinical use. We aimed to evaluate the concordance of CBF maps obtained from SPECT and pseudo-... | Neurological research | 2,020 | 8 | 0 | 0 |
33,245,766 | BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. | Ribosome biogenesis is a fundamental process required for cell proliferation. Although evolutionally conserved, the mammalian ribosome assembly system is more complex than in yeasts. BCCIP was originally identified as a BRCA2 and p21 interacting protein. A partial loss of BCCIP function was sufficient to trigger genomi... | Nucleic acids research | 2,020 | 12 | 0 | 0 |
33,582,524 | Reward and Punishment Sensitivity are Associated with Cross-disorder Traits. | Reversal learning deficits following reward and punishment processing are observed across disruptive behaviors (DB) and attention-deficit/hyperactivity disorder (ADHD), and have been associated with callous-unemotional (CU) traits. However, it remains unknown to what extent these altered reinforcement sensitivities are... | Psychiatry research | 2,021 | 4 | 0 | 0 |
32,827,666 | Nutritional implications of ginger: chemistry, biological activities and signaling pathways. | Ginger (Zingiber officinale Roscoe) has been used as a food, spice, supplement and flavoring agent and in traditional medicines due to its beneficial characteristics such as pungency, aroma, nutrients and pharmacological activity. Ginger and ginger extracts were reported to have numerous effects, such as those on diabe... | The Journal of nutritional biochemistry | 2,020 | 12 | 0 | 0 |
32,949,450 | Expanding Data Collection for the MDSGene Database: X-linked Dystonia-Parkinsonism as Use Case Example. | MDSGene is an online database on movement disorders that collates genetic and clinical knowledge using a standardized published literature abstraction strategy. This review is dedicated to X-linked dystonia-parkinsonism (XDP). We screened 233 citations and curated phenotypic and genotypic data for 414 cases. To reduce ... | Movement disorders : official journal of the Movement Disorder Society | 2,020 | 11 | 0 | 0 |
29,746,088 | Structure-Activity Studies Reveal the Molecular Basis for GABA | α-Conotoxins are disulfide-bonded peptides from cone snail venoms and are characterized by their affinity for nicotinic acetylcholine receptors (nAChR). Several α-conotoxins with distinct selectivity for nAChR subtypes have been identified as potent analgesics in animal models of chronic pain. However, a number of α-co... | ACS chemical biology | 2,018 | 6 | 0 | 0 |
33,135,781 | Autophagy in white matter disorders of the CNS: mechanisms and therapeutic opportunities. | Autophagy is a constitutive process that degrades, recycles and clears damaged proteins or organelles, yet, despite activation of this pathway, abnormal proteins accumulate in neurons in neurodegenerative diseases and in oligodendrocytes in white matter disorders. Here, we discuss the role of autophagy in white matter ... | The Journal of pathology | 2,021 | 2 | 0 | 0 |
29,621,488 | Protected by a Fox. | Cell-specific regulation of gene expression is important for maintaining cortical excitatory/inhibitory balance. In this issue of Neuron, Vuong et al. (2018) reveal an unlikely role for a broadly expressed RNA binding protein, Rbfox1, in protecting inhibitory transmission in the hippocampus. | Neuron | 2,018 | 4 | 0 | 0 |
33,109,133 | Risk factors for incident delirium among urological patients: a systematic review and meta-analysis with GRADE summary of findings. | Post-operative delirium is an important, yet under-researched complication of surgery. Patients undergoing urological surgery may be at especially high risk of POD, as they are often older, and interventions can be associated with conditions that trigger delirium. The main aim of this systematic review was to evaluate ... | BMC urology | 2,020 | 10 | 0 | 0 |
29,745,268 | First treatment and retreatment of medically refractive trigeminal neuralgia by stereotactic radiosurgery versus microvascular decompression: a systematic review and Meta-analysis. | Procedures to treat medically refractory trigeminal neuralgia (MRTN) include stereotactic radiosurgery (SRS) and microvascular decompression (MVD). The aim of this study was to compare outcomes of SRS versus MVD in the treatment of MRTN, with a subgroup focus on those being treated for the first time. | British journal of neurosurgery | 2,018 | 8 | 0 | 0 |
32,763,585 | Plasma MCP-1 levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment. | Neuroinflammation plays a role in the pathophysiology of Bipolar Disorder Depression (BDD) and altered levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1, aka CCL2) have been reported. This study reports specifically on MCP-1 levels, as a potential marker of BDD and/or treatment respons... | Journal of psychiatric research | 2,020 | 10 | 0 | 0 |
33,046,553 | MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons. | Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein critical for normal brain function, and both depletion and overexpression of MeCP2 lead to severe neurodevelopmental disease, Rett syndrome (RTT) and | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,020 | 11 | 0 | 0 |
32,594,235 | The two-way relationship between nicotine and cortical activity: a systematic review of neurobiological and treatment aspects. | Nicotine intake and cortical activity are closely related, as they can influence each other. Nicotine is implicated in the induction and modification of cortical plasticity and excitability, whereas a change on cortical plasticity and excitability can also lead to a modification of the smoking behaviour of an individua... | European archives of psychiatry and clinical neuroscience | 2,021 | 2 | 0 | 0 |
18,937,116 | Endogenous glucocorticoids participate in retinal degeneration during continuous illumination. | Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light-induced retinal degeneration (LIRD). As the increase of glucocorticoids (GC) could also collaborate in the damage, adrenalectomized (ADX) and sham-operated rats (control, CTL) were submitted to CI, and their eyes were stud... | The International journal of neuroscience | 2,008 | 12 | 0 | 0 |
33,454,403 | Arcuate fasciculus architecture is associated with individual differences in pre-attentive detection of unpredicted music changes. | The mismatch negativity (MMN) is an event related brain potential (ERP) elicited by unpredicted sounds presented in a sequence of repeated auditory stimuli. The neural sources of the MMN have been previously attributed to a fronto-temporo-parietal network which crucially overlaps with the so-called auditory dorsal stre... | NeuroImage | 2,021 | 4 | 0 | 0 |
32,725,358 | Embodying melody through a conducting baton: a pilot comparison between musicians and non-musicians. | Finger-tapping tasks have been widely adopted to investigate auditory-motor synchronization, i.e., the coupling of movement with an external auditory rhythm. However, the discrete nature of these movements usually limits their application to the study of beat perception in the context of isochronous rhythms. The purpos... | Experimental brain research | 2,020 | 10 | 0 | 0 |
32,939,646 | Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. | Probable rapid eye movement (REM) sleep behavior disorder (pRBD) is a synucleinopathy-associated parasomnia in which loss of REM sleep muscle atonia results in motor behavior during REM sleep, including dream enactment. Traumatic brain injury is independently associated with increased risk of pRBD and Lewy body disease... | Acta neuropathologica | 2,020 | 12 | 0 | 0 |
29,766,414 | Oral health and oral health risk behaviour in children with and without externalising behaviour problems. | This was to study children with early detected externalising behaviour problems compared to matched controls regarding oral health, oral health risk behaviour and the parental evaluation of the child's oral health and dental care. | European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry | 2,018 | 6 | 0 | 0 |
31,438,171 | Ontology-Driven Real World Evidence Extraction from Clinical Narratives. | Unstructured clinical notes contain a huge amount of information. We investigated the possibility of harvesting such information through an NLP-based approach. A manually curated ontology is the only resource required to handle all the steps of the process leading from clinical narrative to a structured data warehouse ... | Studies in health technology and informatics | 2,019 | 8 | 0 | 0 |
33,212,216 | Lesion of Serotonergic Afferents to the Retrotrapezoid Nucleus Impairs the Tachypneic Response to Hypercapnia in Unanesthetized Animals. | Hypercapnia promotes an increase in pulmonary ventilation due to the stimulation of brainstem chemosensory cells that are connected to the respiratory network. Among these cells are the raphe serotonergic neurons which widely send projections to distinct central respiratory compartments. Nevertheless, the physiological... | Neuroscience | 2,021 | 1 | 0 | 0 |
21,887,175 | Hydrocephalic holoprosencephaly: An oxymoron? Insights into etiology and management. | Holoprosencephaly is usually associated with microcephaly, although macrocephaly is not uncommonly seen. However, the cause of hydrocephalus in holoprosencephaly remains ill-defined. Here, the authors report a case of CSF ascites following ventriculoperitoneal shunt placement in a five month-old child with alobar holop... | Journal of pediatric neurosciences | 2,009 | 1 | 0 | 0 |
37,284,623 | Neurodegeneration: 2021 update. | This article reviews a collection of manuscripts in the field of neurodegenerative disease chosen from what are considered by the author to be among the 10 most important and potentially impactful topics or research trends of 2020 relevant to the field of experimental and diagnostic neuropathology. A deliberate effort ... | Free neuropathology | 2,021 | 1 | 0 | 0 |
32,563,075 | Pseudo-continuous arterial spin labeling MRI study of patients with obsessive-compulsive disorder. | Arterial spin labeling (ASL) magnetic resonance imaging is a novel technique that can measure regional cerebral blood flow (rCBF). Here we used pseudo-continuous ASL (pCASL) to examine the structural and functional imaging data in patients with obsessive-compulsive disorder (OCD). We estimated the gray matter volume im... | Psychiatry research. Neuroimaging | 2,020 | 9 | 0 | 0 |
30,507,652 | Effect of Titanium Particles on the Voltage-Gated Potassium Channel Currents in Trigeminal Root Ganglion Neurons. | Titanium (Ti) is the key material used in dental implants because of its excellent biocompatibility. But wear and corrosion Ti particles had been widely reported to induce inflammation and promote bone absorption. However, little information is known about the damage of Ti particles on neurons. | Implant dentistry | 2,019 | 2 | 0 | 0 |
33,753,814 | Social categorization based on permanent versus transient visual traits in neurotypical children and children with autism spectrum disorder. | The present study was designed to test the relative weight of different types of category markers in children's representations of social and biological kinds. We reasoned that in order to efficiently navigate through the mesh network of overlapping social categories, the representational system dedicated to processing... | Scientific reports | 2,021 | 3 | 0 | 0 |
33,008,094 | Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells. | Air pollution has become one of the most serious issues for human health and has been shown to be particularly concerning for neural and cognitive health. Recent studies suggest that fine particulate matter of less than 2.5 (PM2.5), common in air pollution, can reach the brain, potentially resulting in the development ... | International journal of molecular sciences | 2,020 | 9 | 0 | 0 |
32,992,526 | A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD. | The covalent transfer of the AMP portion of ATP onto a target protein-termed adenylylation or AMPylation-by the human Fic protein HYPE/FICD has recently garnered attention as a key regulatory mechanism in endoplasmic reticulum homeostasis, neurodegeneration, and neurogenesis. As a central player in such critical cellul... | International journal of molecular sciences | 2,020 | 9 | 0 | 0 |
31,183,125 | The analysis of glutamate and glutamine frequencies in human proteins as marker of tissue oxygenation. | In this study, we investigated whether the relative abundance of glutamate and glutamine in human proteins reflects the availability of these amino acids (AAs) dictated by the cellular context. In particular, because hypoxia increases the conversion of glutamate to glutamine, we hypothesized that the ratio glutamate/gl... | Royal Society open science | 2,019 | 4 | 0 | 0 |
23,100,874 | Utility of serum lysosomal enzyme assay in the detection of cerebral sphingolipidoses in patients with progressive neurologic dysfunction. | The cerebral sphingolipidoses which form part of a larger group of lysosomal disorders can be detected and conclusively confirmed by the demonstration of the relevent enzyme deficiency in easily available tissue samples like serum. We have assayed acid β-galactosidase, β-hexosaminidase and its isozymes hexosaminidase A... | Indian journal of clinical biochemistry : IJCB | 1,997 | 7 | 0 | 0 |
33,256,444 | Association of Missense Mutation in FOLH1 With Decreased NAAG Levels and Impaired Working Memory Circuitry and Cognition. | Altering the metabotropic glutamate receptor 3 (mGluR3) by pharmacology or genetics is associated with differences in learning and memory in animals and humans. GRM3 (the gene coding for mGluR3) is also genome-wide associated with risk for schizophrenia. The neurotransmitter | The American journal of psychiatry | 2,020 | 12 | 0 | 0 |
31,647,892 | Dynamics of Neuronal Activity in the Cortical Column during Behavior: Both Neuron Type and Layers Matter. | In this issue of Neuron, Yu et al. (2019) reveal the activity of excitatory cells and GABAergic inhibitory interneurons throughout the neocortical column during active sensation. The authors utilized a combination of spike waveform analysis and genetic tools to identify cell types, demonstrating their distinct patterns... | Neuron | 2,019 | 10 | 0 | 0 |
33,066,894 | Impact of the Coronavirus Disease Pandemic on the Number of Strokes and Mechanical Thrombectomies: A Systematic Review and Meta-Analysis. | This systematic review and meta-analysis aimed to evaluate the impact of the coronavirus disease (COVID-19) pandemic on stroke care, including the number of stroke alerts/codes, number of reperfusions, and number of thrombectomies during the pandemic compared to those during the pre-pandemic period. | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2,020 | 11 | 0 | 0 |
33,542,082 | Nonhuman Primates Satisfy Utility Maximization in Compliance with the Continuity Axiom of Expected Utility Theory. | Expected Utility Theory (EUT), the first axiomatic theory of risky choice, describes choices as a utility maximization process: decision makers assign a subjective value (utility) to each choice option and choose the one with the highest utility. The continuity axiom, central to Expected Utility Theory and its modifica... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,021 | 3 | 0 | 0 |
32,533,744 | Neural networks of different species, brain areas and states can be characterized by the probability polling state. | Cortical networks are complex systems of a great many interconnected neurons that operate from collective dynamical states. To understand how cortical neural networks function, it is important to identify their common dynamical operating states from the probabilistic viewpoint. Probabilistic characteristics of these op... | The European journal of neuroscience | 2,020 | 10 | 0 | 0 |
32,860,323 | Trial-to-Trial Variability in Electrodermal Activity to Odor in Autism. | Abnormal trial-to-trial variability (TTV) has been identified as a key feature of neural processing that is related to increased symptom severity in autism. The majority of studies evaluating TTV have focused on cortical processing. However, identifying whether similar atypicalities are evident in the peripheral nervou... | Autism research : official journal of the International Society for Autism Research | 2,020 | 12 | 0 | 0 |
32,464,148 | The effect of 3-nitropropionic acid on behavioral dysfunction, neuron loss and gliosis in the brain of adult male rats: The case of prefrontal cortex, hippocampus and the cerebellum. | 3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin on different regions of the brain. In the present study, there are ... | Toxicon : official journal of the International Society on Toxinology | 2,020 | 8 | 0 | 0 |
33,858,527 | Efficacy of an integrative approach for bipolar disorder: preliminary results from a randomized controlled trial. | Bipolar disorder (BD) represents one of the most therapeutically complex psychiatric disorders. The development of a feasible comprehensive psychological approach to complement pharmacotherapy to improve its clinical management is required. The main objective of the present randomized controlled trial (RCT) was to test... | Psychological medicine | 2,021 | 4 | 0 | 0 |
32,935,147 | Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration. | Mechanically mediated joint degeneration and cartilage dyshomeostasis is implicated in highly prevalent diseases such as osteoarthritis. Increasingly, MicroRNAs are being associated with maintaining the normal state of cartilage, making them an exciting and potentially key contributor to joint health and disease onset.... | Histochemistry and cell biology | 2,020 | 11 | 0 | 0 |
33,027,630 | Residential greenness and indicators of stress and mental well-being in a Canadian national-level survey. | Residential proximity to greenness in urban areas has been shown to confer a number of health benefits, including improved mental health. We investigated whether greenness was associated with self-reported stress, distress, and mental health among adult participants of multiple cycles of a national Canadian health surv... | Environmental research | 2,021 | 1 | 0 | 0 |
31,430,230 | Observing Erotic Videos with Heterosexual Content Induces Different Cerebral Responses in Homosexual and Heterosexual Men. | To determine the cerebral functionality associated with the perception and processing of erotic stimuli in men with different sexual orientation, this work evaluated the electroencephalographic activity (EEG) from several cortical areas, as well as subjective arousal in homosexual and heterosexual men during observatio... | Journal of homosexuality | 2,021 | 1 | 0 | 0 |
22,946,114 | Giuseppe Ferrario and the epidemiology of apoplexy during the 19th century. | To analyze the pioneering research of Giuseppe Ferrario (1802-1870) on the epidemiology of apoplexy. To our knowledge, his work might have been the first to systematically investigate the epidemiology of cerebrovascular accidents, with the aim of shedding light on the underlying causes. | Neurology | 2,012 | 9 | 0 | 0 |
32,951,262 | Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits. | Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS-induced activity at the whole-brain level. Using a novel 3T magnetic resonance imaging (MRI)-compatible stimulator, we investigate... | Annals of neurology | 2,020 | 12 | 0 | 0 |
31,372,434 | MEG data representing a gamma oscillatory response during the hold/release paradigm. | The article presents magnetoencephalography (MEG) data from healthy participants while undergoing the Hold/Release paradigm. During the paradigm, participants visually perceived a sequence of two letter strings which either assembled into real words (Hold condition) or pseudowords (Release condition). If the first lett... | Data in brief | 2,019 | 4 | 0 | 0 |
32,873,532 | Sexual Orientation-Related Differences in Sexual Satisfaction and Sexual Problems-A Population-Based Study in Sweden. | Human sexuality is a natural and important part of peoples' life and well-being. The underlying interactions affecting sexual satisfaction are complex, and sexual orientation differences partly remain to be identified as well as explained. | The journal of sexual medicine | 2,020 | 12 | 0 | 0 |
32,951,934 | Genetic investigation of amyotrophic lateral sclerosis patients in south Italy: a two-decade analysis. | Amyotrophic lateral sclerosis (ALS) is a multifactorial disease characterized by the interplay of genetic and environmental factors. In the majority of cases, ALS is sporadic, whereas familial forms occur in less than 10% of patients. Herein, we present the results of molecular analyses performed in a large cohort of I... | Neurobiology of aging | 2,021 | 3 | 0 | 0 |
32,951,009 | Metformin effectively restores the HPA axis function in diet-induced obese rats. | The hypothalamo-pituitary-adrenal (HPA) axis is perturbed in obesity. We previously reported presence of leptin resistance in the brainstem and uncoupling between central noradrenergic tone and the HPA axis in obesity-prone (DIO) rats. Metformin is shown to lower body weight and adiposity, but the underlying mechanism ... | International journal of obesity (2005) | 2,021 | 2 | 0 | 0 |
32,180,220 | GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions. | Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occurs. Mutations in leucine-rich repeat kinase 2 (LRRK2) can cause a gene... | Journal of cellular physiology | 2,020 | 10 | 0 | 0 |
29,956,574 | The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder. | To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence of differential expression in individuals with BD. To use the GES to identify new drugs for BD using ... | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry | 2,020 | 12 | 0 | 0 |
32,667,229 | Physiological characterization of a rare subpopulation of doublet-spiking neurons in the ferret lateral geniculate nucleus. | Interest in exploring homologies in the early visual pathways of rodents, carnivores, and primates has recently grown. Retinas of these species contain morphologically and physiologically heterogeneous retinal ganglion cells that form the basis for parallel visual information processing streams. Whether rare retinal ga... | Journal of neurophysiology | 2,020 | 8 | 0 | 0 |
32,833,279 | Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter. | Disturbed sleep is common in epilepsy. The direct influence of nocturnal epileptic activity on sleep fragmentation remains poorly understood. Stereo-electroencephalography paired with polysomnography is the ideal tool to study this relationship. We investigated whether sleep-related epileptic activity is associated wit... | Annals of neurology | 2,020 | 11 | 0 | 0 |
32,607,739 | Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years. | This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder (ASD) in Chinese children. We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling. The Modified Chinese Autism Spectrum Rating Scale was used for the ... | Neuroscience bulletin | 2,020 | 9 | 0 | 0 |
33,588,002 | Divergent Alterations of Structural-Functional Connectivity Couplings in First-episode and Chronic Schizophrenia Patients. | Emerging evidence suggests that the coupling relating the structural connectivity (SC) of the brain to its functional connectivity (FC) exhibits remarkable changes during development, normal aging, and diseases. Although altered structural-functional connectivity couplings (SC-FC couplings) have been previously reporte... | Neuroscience | 2,021 | 4 | 0 | 0 |
36,132,572 | Controllable self-patterning behaviours of flexible self-assembling peptide nanofibers. | In recent years, fabricating flexible one-dimensional nanofibers with a high aspect ratio and controlling their two-dimensional patterns on a certain surface have attracted more and more attention. Although molecular self-assembly as a useful strategy has been widely used to obtain nanofibers from soft materials such a... | Nanoscale advances | 2,021 | 3 | 0 | 0 |
31,434,784 | Mixed methods implementation research of cognitive stimulation therapy (CST) for dementia in low and middle-income countries: study protocol for Brazil, India and Tanzania (CST-International). | In low/middle-income countries (LMICs), the prevalence of people diagnosed with dementia is expected to increase substantially and treatment options are limited, with acetylcholinesterase inhibitors not used as frequently as in high-income countries (HICs). Cognitive stimulation therapy (CST) is a group-based, brief, n... | BMJ open | 2,019 | 8 | 0 | 0 |
34,284,987 | The regulatory mechanisms of behavioral and cognitive aging. | With the increase of life expectancy, the world's population is aging rapidly. Previous work in the field of aging greatly increases our understanding of biological mechanisms underlying longevity. Researchers have unraveled a number of longevity pathways conserved from yeast to mammals. However, recent evidence shows ... | Yi chuan = Hereditas | 2,021 | 6 | 0 | 0 |
33,476,680 | Concurrent E-cigarette and marijuana use and health-risk behaviors among U.S. high school students. | The use of electronic cigarettes (e-cigarettes) and marijuana remain prevalent problems among adolescents nationwide. We assessed current (past 30-day) exclusive e-cigarette use, exclusive marijuana use, and concurrent use with unintentional injury and violent behaviors, alcohol and other drug use behaviors, and sexual... | Preventive medicine | 2,021 | 4 | 0 | 0 |
33,972,904 | Cadaveric Evidence of Complete Transection of the Lumbar Sympathetic Trunk After Extreme Lateral Transpsoas Approach to the Lumbar Spine: A Word of Caution. | Lateral transpsoas approaches to the lumbar spine are believed to entail less risk of injury to the lumbar sympathetic trunk and plexus than anterior approaches. However, even the lateral approach can occasionally injure the sympathetic trunk. We report a literature review and cadaveric case of complete resection of th... | Cureus | 2,021 | 4 | 0 | 0 |
33,688,075 | A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos. | An important strategy for establishing mechanisms of gene function during development is through mutation of individual genes and analysis of subsequent effects on cell behavior. Here, we present a single-plasmid approach for genome editing in chick embryos to study experimentally perturbed cells in an otherwise normal... | Development (Cambridge, England) | 2,021 | 4 | 0 | 0 |
33,520,147 | Effects of a vibrational proprioceptive stimulation on recovery phase after maximal incremental cycle test. | Global Proprioceptive Resonance (GPR) is a recently developed approach conceived to solicit the various cutaneous mechanoreceptors, through application of mechanical multifocal vibration at low amplitude and at definite body sites, limiting the stimulation of the profound structures. This interventional study evaluated... | European journal of translational myology | 2,020 | 12 | 0 | 0 |
31,826,789 | Nonhuman sequence learning findings argue against Hoerl and McCormack's two systems of temporal cognition. | Hoerl & McCormack propose that animals learn sequences through an entrainment-like process, rather than tracking the temporal addresses of each event in a given sequence. However, past research suggests that animals form "temporal maps" of sequential events and also comprehend the concept of ordinal position. These fin... | The Behavioral and brain sciences | 2,019 | 12 | 0 | 0 |
30,189,987 | Sleep and Orofacial Pain. | Sleep and pain share a bidirectional relationship. Therefore, it is important for practitioners managing patients experiencing either sleep and/or pain issues to recognize and understand this complex association from a neurobiological perspective involving neuroanatomic and neurochemical processes. Accounting for the i... | Dental clinics of North America | 2,018 | 10 | 0 | 0 |
32,965,057 | Protocol for a single patient therapy plan: A randomised, double-blind, placebo-controlled N-of-1 trial to assess the efficacy of cannabidiol in patients with intractable epilepsy. | This paper describes the use of the single patient therapy plan (SPTP). The SPTP has been designed to assess the efficacy at an individual level of a commercially available cannabinoid product, cannabidiol, in reducing seizure frequency in paediatric patients with intractable epilepsy. | Journal of paediatrics and child health | 2,020 | 12 | 0 | 0 |
28,471,950 | Comparison of Sleep Latency and Number of SOREMPs in the Home and Hospital With a Modified Multiple Sleep Latency Test: A Randomized Crossover Study. | Comparison of mean sleep latencies and number of sleep-onset rapid eye movement periods (SOREMPs) between modified multiple sleep latency test (MSLT) performed in the unattended home and in-hospital laboratory setting. | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society | 2,017 | 5 | 0 | 0 |
32,388,740 | Prognostic Impact of Preoperative Nutritional Risk in Patients Who Undergo Surgery for Pancreatic Adenocarcinoma. | Nutritional derangements are common hallmarks of pancreatic cancer (PC). Their early detection and management are usually overlooked in routine practice. This study aimed to explore preoperative nutritional status and its prognostic value in patients undergoing surgery for PC. | Annals of surgical oncology | 2,020 | 12 | 0 | 0 |
32,369,706 | Physical activity perceptions, experiences, and beliefs of older adults with mild cognitive impairment or Alzheimer's disease and their care partners. | Physical activity (PA) participation provides functional and social benefits for persons with mild cognitive impairment (MCI) and Alzheimer's disease (AD), but PA participation in these populations is low. To support health promotion initiatives for cognitively impaired older adults, this study explored the perceptions... | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme | 2,020 | 11 | 0 | 0 |
31,173,309 | The future of transcranial magnetic stimulation in neuroscience and neurology in the Middle East. | Transcranial magnetic stimulation (TMS) is a noninvasive technique for brain stimulation often used as a diagnostic and therapeutic therapy in neuroscience and psychiatry for different diseases including epilepsy, stroke, multiple sclerosis, and treatment-resistant major depressive disorders, such as autism and schizop... | European review for medical and pharmacological sciences | 2,019 | 5 | 0 | 0 |
33,578,220 | Early life factors and COVID-19 infection in England: A prospective analysis of UK Biobank participants. | This study aims to examine whether maternal smoking, birth weight, birth month and breastfeeding are associated with COVID-19 infection and hospitalisation. Maternal smoking was positively associated with COVID-19 infection. Breastfeeding was negatively associated with COVID-19 infection. The odds of being hospitalised... | Early human development | 2,021 | 4 | 0 | 0 |
29,632,276 | [Pathomechanism of Autoantibody Production in the Nervous System Diseases]. | Antibodies to different brain and peripheral nerve proteins have recently been found to be associated with several different autoimmune diseases. They can bind to either neuronal or non-neuronal antigens and may have a pathogenic role by themselves or in synergy with other inflammatory mediators after penetrating the b... | Brain and nerve = Shinkei kenkyu no shinpo | 2,018 | 4 | 0 | 0 |
33,045,245 | Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain. | Brain and gonadal hormones interplay controls metabolic and behavioral functions in a sex-related manner. However, most translational neuroscience research related to animal models of endocrine and psychiatric disorders are often carried out in male animals only. The Neuropeptide Y (NPY) system shows sex-dependent diff... | Neuroscience and biobehavioral reviews | 2,020 | 12 | 0 | 0 |
32,598,299 | Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department. | Objectives The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of monocyte distribution width (MDW) for the early identification of sepsis in the ED. Methods We performed a large observational study inclu... | Clinical chemistry and laboratory medicine | 2,020 | 10 | 0 | 0 |
33,217,696 | Prevalence and incidence of multiple sclerosis in Ardabil, Northwest of Iran. | Multiple sclerosis (MS) epidemiology is studies in many populations; however, studying populations with unique characteristics could provide opportunities to deepen the understanding of the underlying reason of the disease. In this regard, we aimed to study the epidemiology of MS in Ardabil, a province in northwest Ira... | Multiple sclerosis and related disorders | 2,021 | 1 | 0 | 0 |
33,393,967 | Finite Element Model of Ocular Adduction by Active Extraocular Muscle Contraction. | In order to clarify the role of the optic nerve (ON) as a load on ocular rotation, we developed a finite element model (FEM) of incremental adduction induced by active contractility of extraocular muscles (EOMs), with and without tethering by the ON. | Investigative ophthalmology & visual science | 2,021 | 1 | 0 | 0 |
33,554,140 | Protocol for quantitative assessment of social cooperation in mice. | Social cooperation in rodents was recently validated in rats, and we recently successfully applied a modified automated analysis to mice. Here, we describe a detailed procedure for using this paradigm in mice that relies on reward-based mutual communication that is automatically detected by a software algorithm embedde... | STAR protocols | 2,021 | 3 | 0 | 0 |
33,007,971 | Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes. | Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking. Using double-fluorescent knock-in mice, we investigated the impact of neuronal co-expression on the internalizatio... | Molecules (Basel, Switzerland) | 2,020 | 9 | 0 | 0 |
31,567,268 | Helmet CPAP as a Bridge From a Rapid Response Activation for Hypoxia Through Awake Tracheostomy in the Operating Room in a Patient With a Difficult Airway: A Case Report. | Continuous positive airway pressure (CPAP) has been used in multiple clinical settings with increasing frequency. However, its use in improving blood oxygenation for difficult airways has never been a specific consideration. Here, we present a rapid response team (RRT) intervention in a patient with severe hypoxia requ... | A&A practice | 2,019 | 11 | 0 | 0 |
23,296,199 | Luminance contrast has little influence on the spread of object-based attention. | We direct our attention to those visual stimuli that are relevant to our behavioral goals. Some of the visual stimuli that surround us are represented more strongly, because they have a higher luminance contrast. However, selective attention also boosts the representation of visual stimuli. It is not yet well understoo... | Vision research | 2,013 | 6 | 0 | 0 |
19,755,129 | A flexible system for hands-free intracranial microinjection. | Neuroscience research projects often use intracranial (IC) microinfusions to target drug delivery to specific brain areas during behavioral testing. These experiments require accurate and precisely-timed delivery of small volumes. We present here a stepper motor-powered micropump assembly for such delivery. This system... | Journal of neuroscience methods | 2,009 | 12 | 0 | 0 |
33,654,818 | Protocol for Measuring Compulsive-like Feeding Behavior in Mice. | Obesity is an important health problem with a strong environmental component that is acquiring pandemic proportion. The high availability of caloric dense foods promotes overeating potentially causing obesity. Animal models are key to validate novel therapeutic strategies, but researchers must carefully select the appr... | Bio-protocol | 2,019 | 7 | 0 | 0 |
26,796,246 | The implications of the new approach to classification: Adults with an intellectual disability. | The new ILAE classification offers the potential for clarity and improved translation of the understanding of the nature of epilepsy in people with an intellectual disability. This is particularly true in the use of the term genetic epilepsy and the removal of the term cryptogenic. However, the definition of the "dysco... | Epilepsy & behavior : E&B | 2,016 | 11 | 0 | 0 |
33,432,877 | Real world prognosis in MS: does early versus late diagnosis matter? | Multiple sclerosis (MS) often presents soon after the onset of a recognized clinically isolated syndrome (CIS). In order to interpret data from CIS trials, it is important to know whether patients presenting as classical CIS provide group data representative of RRMS. | Neurological research | 2,021 | 6 | 0 | 0 |
33,200,103 | COVID-19 and stroke: Red flags for secondary movement disorders? | •Hypercoagulability may predispose COVID-19 patients to thromboembolic complications.•Movement disorders may develop as complications of vascular events and infections.•Health professionals should be vigilant for abnormal movements in COVID-19 patients. | eNeurologicalSci | 2,020 | 12 | 0 | 0 |
32,795,554 | Covariation between Childhood-Trauma Related Resting-State Functional Connectivity and Affective Temperaments is Impaired in Individuals with Major Depressive Disorder. | Affective temperaments and childhood-trauma experiences are associated with major depressive disorder (MDD). So far, how the covariation between distinct affective temperaments and childhood-trauma insulted brain functional connectivities (FCs) contribute to MDD remains unclear. Here, we aimed to investigate whether ce... | Neuroscience | 2,021 | 1 | 0 | 0 |
33,638,793 | Part I: The Complex Spikes as One of the Cerebellar Secrets. | The olivocerebellar tract has unique morphological, physiological, and developmental properties. Olivocerebellar axons are the source of multiple climbing fibers (CFs). The synapse between CFs and the Purkinje neuron is one of the most powerful excitatory in the central nervous system. Complex spikes are composed of an... | Cerebellum (London, England) | 2,021 | 6 | 0 | 0 |
32,559,304 | Environmental Complexity and Research Outcomes. | Environmental complexity is an experimental paradigm as well as a potential part of animals' everyday housing experiences. In experimental uses, researchers add complexity to stimulate brain development, delay degenerative brain changes, elicit more naturalistic behaviors, and test learning and memory. Complexity can e... | ILAR journal | 2,020 | 10 | 0 | 0 |
33,038,358 | Improved functional and histochemical outcomes in l-DOPA plus tolcapone treated VMAT2-deficient mice. | Parkinson disease is typically treated with L-3,4-dihydroxyphenylalanine (or levodopa) co-prescribed with concentration stabilizers to prevent undesired motor fluctuations. However, the beneficial role of the chronic combined therapy on disease progression has not been thoroughly explored. We hypothesized that tolcapon... | Neuropharmacology | 2,020 | 12 | 0 | 0 |
33,465,414 | Matrix Metalloproteinase-9 Expression is Enhanced by Ischemia and Tissue Plasminogen Activator and Induces Hemorrhage, Disability and Mortality in Experimental Stroke. | Matrix metalloproteinase-9 (MMP-9) degrades collagen and other cellular matrix proteins. After acute ischemic stroke, increased MMP-9 levels are correlated with hemorrhage, lack of reperfusion and stroke severity. Nevertheless, definitive data that MMP-9 itself causes poor outcomes in ischemic stroke are limited. In a ... | Neuroscience | 2,021 | 4 | 0 | 0 |
32,680,963 | Morphological profiling of tubercle bacilli identifies drug pathways of action. | Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial organization. Here we utilized the cell-to-cell variation in morphological features of | Proceedings of the National Academy of Sciences of the United States of America | 2,020 | 8 | 0 | 0 |
32,707,531 | Ocrelizumab exposure in the second trimester of pregnancy without neonatal B-cell depletion. | Management of multiple sclerosis (MS) before and during pregnancy remains challenging given there are no disease-modifying therapies (DMTs) approved for use during pregnancy, and discontinuation of certain DMTs can lead to rebound relapses. Ocrelizumab is a highly effective therapy for relapsing-remitting MS (RRMS) wit... | Multiple sclerosis and related disorders | 2,020 | 10 | 0 | 0 |
33,271,327 | HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex. | The neuronal RNA-binding protein (RBP) HuD plays an important role in brain development, synaptic plasticity and neurodegenerative diseases such as Parkinson's (PD) and Alzheimer's (AD). Bioinformatics analysis of the human SOD1 mRNA 3' untranslated region (3'UTR) demonstrated the presence of HuD binding adenine-uridin... | Neurobiology of disease | 2,021 | 1 | 0 | 0 |
32,851,476 | Demographic and clinical determinants of neck pain in idiopathic cervical dystonia. | Cervical dystonia is associated with neck pain in a significant proportion of cases, but the mechanisms underlying pain are largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients with and without neck pain from the Italian Dystonia Registry. Univariable ... | Journal of neural transmission (Vienna, Austria : 1996) | 2,020 | 10 | 0 | 0 |
34,336,508 | Neuropsychiatric Lupus: A Challenging Journey of a Patient With Pulmonary Tuberculosis. | Systemic lupus erythematosus (SLE) is a disease that affects multiple systems in the body. Due to its variable manifestations, it can at times pose challenges for physicians to hold SLE as the culprit behind an affected system. This is most true when encountering patients with neuropsychiatric manifestations of SLE. We... | Cureus | 2,021 | 6 | 0 | 0 |
32,448,020 | Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study. | 22q11.2 deletion syndrome (22q11.2DS) is associated with impaired cognitive functioning. Glutamatergic pathways have been linked with cognition and are hypothesized to be disrupted in 22q11.2DS patients, possibly 'shifting' the excitatory (glutamate)/inhibitory (GABA) balance. Hence, the glutamate/GABA balance may cons... | Journal of psychopharmacology (Oxford, England) | 2,020 | 8 | 0 | 0 |
33,014,732 | The clinical utilities of multi-pinhole single photon emission computed tomography. | Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimat... | Quantitative imaging in medicine and surgery | 2,020 | 10 | 0 | 0 |
32,944,570 | I SPY WITH MY LITTLE EYE: WHAT VISUAL SEARCH CAN TELL US ABOUT HOW WE SEE THE WORLD. | We have all have experienced the frustration of looking for something we want, only to find a seemingly endless series of things we do not want. This process of looking for an object of interest is called visual search. We perform visual search all the time in everyday life, because the objects we want are almost alway... | Frontiers for young minds | 2,019 | 1 | 0 | 0 |
23,883,761 | The use of non-interactive scenarios in social neuroscience. | Although we fundamentally agree with Schilbach et al., we argue here that there is still some residual utility for non-interactive scenarios in social neuroscience. They may be useful to quantify individual differences in prosocial inclination that are not influenced by concerns about reputation or social pressure. | The Behavioral and brain sciences | 2,013 | 8 | 0 | 0 |
33,291,600 | Clinical and Pathological Characteristics of Metastatic Renal Cell Carcinoma Patients Needing a Second-Line Therapy: A Systematic Review. | A high percentage of patients with metastatic renal cell carcinoma (mRCC) require a second-line option. We aimed to summarize available evidences about the clinicopathological profile of mRCC patients who receive a second-line therapy. A systematic review was performed in August 2020. We included papers that met the fo... | Cancers | 2,020 | 12 | 0 | 0 |
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