pmid int64 7.11M 40.4M | title stringlengths 1 553 | abstract stringlengths 200 10.9k | journal stringlengths 3 239 | pub_year int64 1.98k 2.02k | pub_month int64 1 12 | citation_count_within_one_year int64 0 281 | citation_count_within_five_years int64 0 1.17k |
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33,926,981 | Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: protocol for a systematic review and meta-analysis. | Despite available pharmacological and psychological treatments, remission rates for bipolar disorder remain relatively low. Current research implicates the experience of childhood trauma as a potential moderator of poor treatment outcomes among individuals with bipolar disorder. To date, the evidence reporting the infl... | BMJ open | 2,021 | 4 | 1 | 1 |
30,451,069 | Evaluating Cerebrovascular Reactivity during the Early Symptomatic Phase of Sport Concussion. | Cerebrovascular reactivity (CVR) indexes the ability of blood vessels to respond to vasoactive stimuli and may be a sensitive biomarker of concussion. However, alterations in whole-brain CVR remain poorly understood during the early symptomatic phase of injury. In this study, CVR was assessed using blood-oxygenation-le... | Journal of neurotrauma | 2,019 | 5 | 2 | 18 |
24,356,107 | Creatine supports propagation and promotes neuronal differentiation of inner ear progenitor cells. | Long-term propagation of inner ear-derived progenitor/stem cells beyond the third generation and differentiation into inner ear cell types has been shown to be feasible, but challenging. We investigated whether the known neuroprotective guanidine compound creatine (Cr) promotes propagation of inner ear progenitor/stem ... | Neuroreport | 2,014 | 5 | 1 | 4 |
33,314,443 | Extended-amygdala intrinsic functional connectivity networks: A population study. | Pre-clinical and human neuroimaging research implicates the extended-amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance-use behaviours. The extent to which individual Ext... | Human brain mapping | 2,021 | 4 | 1 | 4 |
30,831,159 | Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules. | Adhesion proteins play crucial roles at synapses, not only by providing a physical trans-synaptic linkage between axonal and dendritic membranes, but also by connecting to functional elements including the pre-synaptic neurotransmitter release machinery and post-synaptic receptors. To mediate these functions, adhesion ... | Neuropharmacology | 2,020 | 6 | 4 | 13 |
29,945,903 | Actin filaments partition primary cilia membranes into distinct fluid corrals. | Physical properties of primary cilia membranes in living cells were examined using two independent, high-spatiotemporal-resolution approaches: fast tracking of single quantum dot-labeled G protein-coupled receptors and a novel two-photon super-resolution fluorescence recovery after photobleaching of protein ensemble. B... | The Journal of cell biology | 2,018 | 8 | 6 | 36 |
24,991,962 | Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. | Memory traces are believed to be ensembles of cells used to store memories. To visualize memory traces, we created a transgenic line that allows for the comparison between cells activated during encoding and expression of a memory. Mice re-exposed to a fear-inducing context froze more and had a greater percentage of re... | Neuron | 2,014 | 7 | 11 | 163 |
23,804,090 | Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons. | The embryonic sympathetic nervous system consists of predominantly noradrenergic neurons and a very small population of cholinergic neurons. Postnatal development further allows target-dependent switch of a subset of noradrenergic neurons into cholinergic phenotype. How embryonic cholinergic neurons are specified at th... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,013 | 6 | 0 | 9 |
33,319,744 | Comprehension of computer code relies primarily on domain-general executive brain regions. | Computer programming is a novel cognitive tool that has transformed modern society. What cognitive and neural mechanisms support this skill? Here, we used functional magnetic resonance imaging to investigate two candidate brain systems: the multiple demand (MD) system, typically recruited during math, logic, problem so... | eLife | 2,020 | 12 | 15 | 66 |
21,671,841 | Retrospective chart review of duloxetine and pregabalin in the treatment of painful neuropathy. | The primary aims of our study were to compare pregabalin and duloxetine in a neuromuscular clinic for diabetic neuropathic pain (DPN) and to study the effect of these medications in cryptogenic sensory polyneuropathy. We performed a retrospective chart review of 143 patients who were started on pregabalin or duloxetine... | The International journal of neuroscience | 2,011 | 9 | 3 | 10 |
34,193,913 | Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging. | Postpartum depression (PPD) affects approximately 1 in 10 women after childbirth. A thorough understanding of a preexisting vulnerability to PPD will likely aid the early detection and treatment of PPD. Using a within-sample association, the study examined whether the brain's structural and functional alterations predi... | Scientific reports | 2,021 | 6 | 4 | 16 |
28,993,204 | A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. | Recent progress in electrophysiological and optical methods for neuronal recordings provides vast amounts of high-resolution data. In parallel, the development of computer technology has allowed simulation of ever-larger neuronal circuits. A challenge in taking advantage of these developments is the construction of sin... | Journal of neuroscience methods | 2,018 | 1 | 2 | 20 |
24,943,843 | Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules. | Adrenal chromaffin cells release hormones and neuropeptides that are essential for physiological homeostasis. During this process, secretory granules fuse with the plasma membrane and deliver their cargo to the extracellular space. It was once believed that fusion was the final regulated step in exocytosis, resulting i... | Molecular biology of the cell | 2,014 | 8 | 2 | 24 |
20,927,333 | Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. | Olig1 is a basic helix-loop-helix (bHLH) transcription factor that is essential for oligodendrogenesis and efficient remyelination. However, its role in neurodegenerative disorders has not been well-elucidated. | PloS one | 2,010 | 9 | 2 | 22 |
20,510,586 | Coping flexibility in young adults: comparison between subjects with and without schizotypal personality features. | The current study examined characteristics of coping patterns adopted by college students in mainland China. In particular, it examined the coping strategies adopted by subjects with schizotypal personality (SPD) features compared to those without SPD features, and compared the relative effectiveness of their coping. F... | Schizophrenia research | 2,010 | 9 | 0 | 9 |
30,430,321 | Social Conformity in Autism. | Humans are extremely susceptible to social influence. Here, we examine whether this susceptibility is altered in autism, a condition characterized by social difficulties. Autistic participants (N = 22) and neurotypical controls (N = 22) completed a memory test of previously seen words and were then exposed to answers s... | Journal of autism and developmental disorders | 2,019 | 3 | 1 | 12 |
28,546,077 | Systemic administration of l-kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice. | The kynurenine pathway is a cascade of enzymatic steps generating biologically active compounds. l-kynurenine (l-KYN) is a central metabolite of tryptophan degradation. In the mammalian brain, l-KYN is partly converted to kynurenic acid (KYNA), which exerts multiple effects on neurotransmission. Recently, l-KYN or one ... | Microvascular research | 2,017 | 11 | 0 | 4 |
31,642,807 | Neural precursors of decisions that matter-an ERP study of deliberate and arbitrary choice. | The readiness potential (RP)-a key ERP correlate of upcoming action-is known to precede subjects' reports of their decision to move. Some view this as evidence against a causal role for consciousness in human decision-making and thus against free-will. But previous work focused on arbitrary decisions-purposeless, unrea... | eLife | 2,019 | 10 | 5 | 44 |
24,697,290 | Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties. | (-)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinson's di... | Journal of medicinal chemistry | 2,014 | 5 | 6 | 34 |
30,035,325 | Resilience predicts remission in antidepressant treatment of geriatric depression. | With the world population rapidly aging, it is increasingly important to identify sociodemographic, cognitive, and clinical features that predict poor outcome in geriatric depression. Self-report measures of resilience-ie, the ability to adapt and thrive in the face of adversity-may identify those depressed older adult... | International journal of geriatric psychiatry | 2,018 | 12 | 5 | 17 |
24,744,858 | Influence of cutaneous and muscular circulation on spatially resolved versus standard Beer-Lambert near-infrared spectroscopy. | The potential interference of cutaneous circulation on muscle blood volume and oxygenation monitoring by near-infrared spectroscopy (NIRS) remains an important limitation of this technique. Spatially resolved spectroscopy (SRS) was reported to minimize the contribution of superficial tissue layers in cerebral monitorin... | Physiological reports | 2,013 | 12 | 1 | 25 |
28,236,843 | Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity. | The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major... | Medical hypotheses | 2,017 | 3 | 3 | 28 |
30,902,980 | Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. | Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly contro... | Nature communications | 2,019 | 3 | 9 | 150 |
31,129,368 | Delayed cortical maturation at the centrotemporal brain regions in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). | Benign childhood epilepsy with centrotemporal spikes (BCECTS) is an epilepsy syndrome commonly found in child and adolescent. Although the prognosis is mostly favorable as long as the seizure is well controlled. However, they are often suffering from the cognitive and behavioral problems which might be the consequences... | Epilepsy research | 2,019 | 8 | 0 | 2 |
25,805,403 | Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2). | To assess the psychometric properties of the Italian adaptation of the Hypomania-Check-List 32-item, second revision (HCL-32-R2) for the detection of bipolarity in major depressive disorder (MDD) treatment-seeking outpatients. | Journal of affective disorders | 2,015 | 6 | 1 | 10 |
32,184,415 | The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding. | Alpha-synuclein (aSyn)-rich aggregates propagate in neuronal networks and compromise cellular homeostasis leading to synucleinopathies such as Parkinson's disease. Aggregated aSyn spread follows a conserved spatio-temporal pattern that is not solely dependent on connectivity. Hence, the differential tropism of aSyn-ric... | Scientific reports | 2,020 | 3 | 7 | 58 |
23,200,194 | Using a million cell simulation of the cerebellum: network scaling and task generality. | Several factors combine to make it feasible to build computer simulations of the cerebellum and to test them in biologically realistic ways. These simulations can be used to help understand the computational contributions of various cerebellar components, including the relevance of the enormous number of neurons in the... | Neural networks : the official journal of the International Neural Network Society | 2,013 | 11 | 0 | 16 |
28,377,175 | Tactile object categories can be decoded from the parietal and lateral-occipital cortices. | The visual system classifies objects into categories, and distinct populations of neurons within the temporal lobe respond preferentially to objects of a given perceptual category. We can also classify the objects we recognize with the sense of touch, but less is known about the neuronal correlates underlying this cogn... | Neuroscience | 2,017 | 6 | 0 | 7 |
24,549,293 | Accurate metacognition for visual sensory memory representations. | The capacity to attend to multiple objects in the visual field is limited. However, introspectively, people feel that they see the whole visual world at once. Some scholars suggest that this introspective feeling is based on short-lived sensory memory representations, whereas others argue that the feeling of seeing mor... | Psychological science | 2,014 | 4 | 2 | 24 |
17,627,942 | Exocytotic release of ATP from cultured astrocytes. | Astrocytes appear to communicate with each other as well as with neurons via ATP. However, the mechanisms of ATP release are controversial. To explore whether stimuli that increase [Ca(2+)](i) also trigger vesicular ATP release from astrocytes, we labeled ATP-containing vesicles with the fluorescent dye quinacrine, whi... | The Journal of biological chemistry | 2,007 | 9 | 11 | 92 |
30,357,316 | Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks. | Dopaminergic projections are hypothesized to stabilize neural signaling and neural representations, but how they shape regional information processing and large-scale network interactions remains unclear. Here we investigated effects of lowered dopamine levels on within-region temporal signal variability (measured by s... | Cerebral cortex (New York, N.Y. : 1991) | 2,019 | 1 | 13 | 78 |
28,912,081 | Towards understanding rTMS mechanism of action: Stimulation of the DLPFC causes network-specific increase in functional connectivity. | Transcranial magnetic stimulation (TMS) is a powerful non-invasive technique for the modulation of brain activity. While the precise mechanism of action is still unknown, TMS is applied in cognitive neuroscience to establish causal relationships between stimulation and subsequent changes in cerebral function and behavi... | NeuroImage | 2,017 | 11 | 9 | 109 |
29,523,945 | Comparison of cerebral perfusion in perimesencephalic subarachnoid hemorrhage and aneurysmal subarachnoid hemorrhage. | Perimesencephalic hemorrhage (PMH) is a benign subtype of nonaneurysmal subarachnoid hemorrhage (SAH). We aimed to investigate if cerebral perfusion in PMH is less affected than in aneurysmal SAH (aSAH). | Neuroradiology | 2,018 | 6 | 2 | 4 |
26,349,765 | The Epigenetic Reader BRD2 as a Specific Modulator of PAI-1 Expression in Lipopolysaccharide-Stimulated Mouse Primary Astrocytes. | The post translational modification of lysine acetylation is a key mechanism that regulates chromatin structure. Epigenetic readers, such as the BET domains, are responsible for reading histone lysine acetylation which is a hallmark of open chromatin structure, further providing a scaffold that can be accessed by RNA p... | Neurochemical research | 2,015 | 11 | 2 | 6 |
26,258,776 | A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA). | Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and the leading genetic cause of death in infants. Despite the disease-causing gene, survival motor neuron (SMN1), encodes a ubiquitous protein, SMN1 deficiency preferentially affects spinal motor neurons (MNs), leaving the basis of this selective cel... | International journal of molecular sciences | 2,015 | 8 | 2 | 12 |
25,086,773 | QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators. | Two QSAR approaches were applied to assist the design and to prioritise the synthesis of new active mGlu2 receptor positive allosteric modulators (PAMs). With the aim to explore a particular point of substitution the models successfully prioritised molecules originating from chemistry ideas and a large virtual library.... | Journal of molecular graphics & modelling | 2,014 | 9 | 1 | 16 |
31,692,680 | Alpha synuclein in hematopoiesis and immunity. | Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a small protein expressed mainly in neurons but can also be found i... | Heliyon | 2,019 | 10 | 1 | 44 |
25,680,364 | Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. | Opioid tolerance is a limiting factor in chronic pain. Delta opioid peptide (DOP)(δ) receptor antagonism has been shown to reduce tolerance. Here, the common clinical mu opioid peptide (MOP)(µ) receptor agonist fentanyl has been linked to the DOP antagonist Dmt-Tic (2',6'-dimethyl-L-tyrosyl-1,2,3,4-tetrahydrisoquinolin... | British journal of anaesthesia | 2,015 | 4 | 0 | 5 |
27,325,209 | Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease? | Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD. Moreover, insufficient sleep facilitates accumulation of amyloid-β (Aβ), potentially triggering earlier cognitive decline and conversion to AD. Buildi... | Trends in neurosciences | 2,016 | 8 | 21 | 206 |
23,931,992 | The need for research maps to navigate published work and inform experiment planning. | The increasing volume, complexity, and interconnectedness of published studies in neuroscience make it difficult to determine what is known, what is uncertain, and how to contribute effectively to one's field. There is a pressing need to develop automated strategies to help researchers navigate the vastness of the publ... | Neuron | 2,013 | 8 | 1 | 7 |
33,770,610 | Psychological status after insulo-opercular resection in patients with epilepsy: Depression, anxiety, and quality of life. | Insular epilepsy is increasingly recognized in epilepsy surgery centers. Recent studies suggest that resection of an epileptogenic zone that involves the insula as a treatment for drug-resistant seizures is associated with good outcomes in terms of seizure control. However, despite the existing evidence of a role of th... | Epilepsy & behavior : E&B | 2,021 | 5 | 0 | 5 |
24,780,955 | Immediate effect of spinal magnetic stimulation on camptocormia in Parkinson's disease. | Spinal cord stimulation is a potential therapeutic option for the treatment of Parkinson's disease (PD)-associated symptoms. Repetitive trans-spinal magnetic stimulation (rTSMS) is a non-invasive and safe alternative for stimulation of spinal pathways that has not been studied for therapeutic efficacy in PD. We assesse... | Journal of neurology, neurosurgery, and psychiatry | 2,014 | 11 | 7 | 18 |
30,937,695 | Exploring physicians, nurses and ward-based pharmacists working relationships in a Swedish inpatient setting: a mixed methods study. | Background In Sweden there has been limited work investigating the integration and nature of collaborative relationships between pharmacists and other healthcare practitioners. Objective To explore the working relationships of physicians, nurses and ward-based pharmacists in a rural hospital after the introduction of a... | International journal of clinical pharmacy | 2,019 | 6 | 2 | 20 |
19,186,032 | Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex. | Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory, executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known about the molecular mechanisms underlying D1-NMDA receptors interactions in this brain area. Here, we show that D1 receptors and the NMDA ... | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 2,009 | 4 | 6 | 23 |
22,079,491 | Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. | Acetylcholinesterase (AChE) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (TBI). Repeated blast exposure induces TBI (blast TBI) with a variable neuropathology at different brain regions. Since ACh... | Neuroscience letters | 2,012 | 1 | 2 | 9 |
29,728,693 | Applications and efficiencies of the first cat 63K DNA array. | The development of high throughput SNP genotyping technologies has improved the genetic dissection of simple and complex traits in many species including cats. The properties of feline 62,897 SNPs Illumina Infinium iSelect DNA array are described using a dataset of over 2,000 feline samples, the most extensive to date,... | Scientific reports | 2,018 | 5 | 2 | 36 |
26,243,231 | Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial. | The Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator (r-tPA; CLEAR) in Acute Ischemic Stroke (AIS) and CLEAR-Enhanced Regimen (CLEAR-ER) trials demonstrated safety of reduced dose r-tPA plus the glycoprotein 2b/3a inhibitor, eptifibatide, in AIS compared with r-tPA alo... | Stroke | 2,015 | 9 | 3 | 25 |
26,391,125 | Differential motor and prefrontal cerebello-cortical network development: Evidence from multimodal neuroimaging. | While our understanding of cerebellar structural development through adolescence and young adulthood has expanded, we still lack knowledge of the developmental patterns of cerebellar networks during this critical portion of the lifespan. Volume in lateral posterior cerebellar regions associated with cognition and the p... | NeuroImage | 2,016 | 1 | 2 | 30 |
27,401,224 | Prognostic factors for survival in patients with amyotrophic lateral sclerosis: analysis of a multi-centre clinical trial. | Information regarding factors influencing prognosis and quality of life (QoL) in patients with amyotrophic lateral sclerosis (ALS) is useful for clinicians and also for patients and their carers. The aims of this study are to identify prognostic factors for survival in ALS and to determine the physical factors influenc... | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2,016 | 10 | 1 | 8 |
30,741,601 | Human NOC3 is essential for DNA replication licensing in human cells. | Noc3p (Nucleolar Complex-associated protein) is an essential protein in budding yeast DNA replication licensing. Noc3p mediates the loading of Cdc6p and MCM proteins onto replication origins during the M-to-G | Cell cycle (Georgetown, Tex.) | 2,019 | 3 | 0 | 4 |
20,577,882 | Phonotaxis to male's calls embedded within a chorus by female gray treefrogs, Hyla versicolor. | During the reproductive season, male Hyla versicolor produce advertisement calls to attract females. Females exhibit phonotaxis and approach the individual callers, resulting in amplexus. For frogs that call from dense choruses, the extent to which and the range from which a male's advertisement call within a chorus ca... | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology | 2,010 | 8 | 0 | 11 |
32,516,938 | Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. | Genetic and genomic studies of brain disease increasingly demonstrate disease-associated interactions between the cell types of the brain. Increasingly complex and more physiologically relevant human-induced pluripotent stem cell (hiPSC)-based models better explore the molecular mechanisms underlying disease but also c... | Cells | 2,020 | 6 | 0 | 4 |
33,675,270 | Clinical, biochemical, and genotype-phenotype correlations of 118 patients with Niemann-Pick disease Types A/B. | Niemann-Pick disease Types A and B (NPA/B) are autosomal recessive disorders caused by variants in the sphingomyelin phosphodiesterase-1 (SMPD1) gene. This study aimed to describe and characterize a cohort of 118 patients diagnosed with NPA/B based on clinical, biochemical, and molecular findings, and to identify sound... | Human mutation | 2,021 | 5 | 3 | 24 |
29,024,786 | Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. | Repeated use of opioids can lead to the development of analgesic tolerance and dependence. Additionally, chronic opioid exposure can cause a paradoxical emergence of heightened pain sensitivity to noxious stimuli, termed hyperalgesia, which may drive continued or escalated use of opioids to manage worsening pain sympto... | Neuroscience | 2,017 | 12 | 2 | 20 |
28,685,178 | Time-based event expectancies in children with Autism spectrum disorder. | Here, we studied the time-based event expectancies in children with Autism spectrum disorder. Nine children with Autism spectrum disorders and ten (6-11 years) typically developing children participated. In a choice-response task with two different pre-target intervals, participants had to indicate the left or right di... | Experimental brain research | 2,017 | 9 | 0 | 7 |
28,981,614 | Neurotensin Broadly Recruits Inhibition via White Matter Neurons in the Mouse Cerebral Cortex: Synaptic Mechanisms for Decorrelation. | The neuropeptide, neurotensin (NT), inhibits UP state generation in the cerebral cortex and temporally restricts the response to thalamic input, likely by a generalized increase in inhibition. To investigate the cellular and circuit substrate(s) for how a neuropeptide can shift the balance between cortical excitation a... | Cerebral cortex (New York, N.Y. : 1991) | 2,018 | 8 | 2 | 4 |
22,539,857 | Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling. | Erythropoietin (EPO) is typically known for its role in erythropoiesis but is also a potent neurotrophic/neuroprotective factor for spinal motor neurons. Another trophic factor regulated by hypoxia-inducible factor-1, vascular endothelial growth factor (VEGF), signals via ERK and Akt activation to elicit long-lasting p... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,012 | 4 | 4 | 28 |
27,716,964 | Immediate Neural Plasticity Involving Reaction Time in a Saccadic Eye Movement Task is Intact in Children With Fetal Alcohol Spectrum Disorder. | Saccades are rapid eye movements that bring an image of interest onto the retina. Previous research has found that in healthy individuals performing eye movement tasks, the location of a previous visual target can influence performance of the saccade on the next trial. This rapid behavioral adaptation represents a form... | Alcoholism, clinical and experimental research | 2,016 | 11 | 0 | 1 |
22,083,597 | Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization. | Picrotoxin and t-butylbicyclophosphorothionate (TBPS) are GABA(A) receptor (GABA(A)R) open channel blockers. However, picrotoxin displaceable [(35)S]TBPS binding to α1β2γ2 GABA(A)Rs occurs in the absence of GABA, suggesting that access to the binding site is independent of activation. Alternatively, spontaneous gating ... | The Journal of physiology | 2,012 | 1 | 1 | 7 |
25,504,741 | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | Distraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful stimuli, thereby reducing perceived pain. We have recently developed a rat model that provides an opportuni... | European journal of pain (London, England) | 2,015 | 9 | 0 | 6 |
23,011,918 | Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes. | RCAN1 is a chromosome 21 gene that controls secretion in endocrine cells, regulates mitochondrial function, and is sensitive to oxidative stress. Regulator of calcineurin 1 (RCAN1) is also an endogenous inhibitor of the protein phosphatase calcineurin, the inhibition of which leads to hypoinsulinemia and diabetes in hu... | Endocrinology | 2,012 | 11 | 0 | 14 |
32,173,153 | Carbon fiber reinforced vs titanium implants for fixation in spinal metastases: A comparative clinical study about safety and effectiveness of the new "carbon-strategy". | In spinal oncology traditional titanium implants could significantly impair evaluation of postoperative imaging because of artifacts, potentially affecting proper planning and execution of radiotherapy and adequate radiological follow-up to rule out progression of the disease. This is why carbon fiber reinforced (CFR)-... | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2,020 | 5 | 7 | 48 |
27,698,428 | Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. | Human neural progenitors derived from pluripotent stem cells develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. By combining patch clamping, morphological and transcriptome analysis on single-human neurons in vitro, we ... | Molecular psychiatry | 2,016 | 11 | 4 | 86 |
28,545,908 | Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods. | Recent interest in the lasting effects of early-life stress has expanded to include effects on cognitive performance. An increase in circulating glucocorticoids is induced by stress exposure and glucocorticoid effects on the hippocampus likely underlie many of the cognitive consequences. Here we review studies showing ... | Neurobiology of learning and memory | 2,017 | 9 | 0 | 5 |
25,873,042 | The dopamine theory of addiction: 40 years of highs and lows. | For several decades, addiction has come to be viewed as a disorder of the dopamine neurotransmitter system; however, this view has not led to new treatments. In this Opinion article, we review the origins of the dopamine theory of addiction and discuss the ability of addictive drugs to elicit the release of dopamine in... | Nature reviews. Neuroscience | 2,015 | 5 | 30 | 254 |
28,744,955 | Cortical connectivity modulation during sleep onset: A study via graph theory on EEG data. | Sleep onset is characterized by a specific and orchestrated pattern of frequency and topographical EEG changes. Conventional power analyses of electroencephalographic (EEG) and computational assessments of network dynamics have described an earlier synchronization of the centrofrontal areas rhythms and a spread of sync... | Human brain mapping | 2,017 | 11 | 2 | 38 |
25,350,774 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. | Mesiotemporal sclerosis (MTS), the most frequent form of drug-resistant temporal lobe epilepsy, often develops after an initial precipitating injury affecting the immature brain. To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expr... | The European journal of neuroscience | 2,014 | 12 | 0 | 8 |
31,707,193 | Functional reorganization during the recovery of contralesional target selection deficits after prefrontal cortex lesions in macaque monkeys. | Visual extinction has been characterized by the failure to respond to a visual stimulus in the contralesional hemifield when presented simultaneously with an ipsilesional stimulus (Corbetta and Shulman, 2011). Unilateral damage to the macaque frontoparietal cortex commonly leads to deficits in contralesional target sel... | NeuroImage | 2,020 | 2 | 1 | 14 |
27,355,516 | Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. | Altered Rho GTPase signaling has been linked to many types of cancer. As many small G proteins, Rho GTPases cycle between an active and inactive state thanks to specific regulators that catalyze exchange of GDP into GTP (Rho-GEF) or hydrolysis of GTP into GDP (Rho-GAP). Recent studies have shown that alteration takes p... | Small GTPases | 2,017 | 4 | 0 | 3 |
24,388,038 | A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. | Recent research has seen low-dose ketamine emerge as a novel, rapid-acting antidepressant. Ketamine, an N-methy-d-aspartate (NMDA) receptor antagonist, leads to effects on the glutamatergic system and abnormalities in this neurotransmittor system are present in depression. This article aims to (1) review the clinical l... | Journal of affective disorders | 2,014 | 3 | 18 | 113 |
31,914,896 | Neuropathic Pain: Mechanism-Based Therapeutics. | Neuropathic pain (NeP) can result from sources as varied as nerve compression, channelopathies, autoimmune disease, and incision. By identifying the neurobiological changes that underlie the pain state, it will be clinically possible to exploit mechanism-based therapeutics for maximum analgesic effect as diagnostic acc... | Annual review of pharmacology and toxicology | 2,020 | 1 | 15 | 166 |
25,563,647 | Ethanol and normobaric oxygen: novel approach in modulating pyruvate dehydrogenase complex after severe transient and permanent ischemic stroke. | Ischemic stroke induces metabolic disarray. A central regulatory site, pyruvate dehydrogeanse complex (PDHC) sits at the cross-roads of 2 fundamental metabolic pathways: aerobic and anaerobic. In this study, we combined ethanol (EtOH) and normobaric oxygen (NBO) to develop a novel treatment to modulate PDHC and its reg... | Stroke | 2,015 | 2 | 6 | 19 |
23,843,519 | TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway. | Toll-like receptors (TLRs) recognize both pathogen- and danger-associated molecular patterns and induce innate immune responses. Some TLRs are expressed in neurons and regulate neurodevelopment and neurodegeneration. However, the downstream signaling pathways and effectors for TLRs in neurons are still controversial. I... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,013 | 7 | 3 | 20 |
28,657,428 | Abnormal functional connectivity of thalamic sub-regions contributes to fatigue in multiple sclerosis. | To investigate sub-regional thalamic resting-state (RS) functional connectivity (FC) abnormalities in multiple sclerosis (MS) and their correlation with fatigue and its subcomponents (physical, cognitive, and psychosocial). | Multiple sclerosis (Houndmills, Basingstoke, England) | 2,018 | 8 | 8 | 44 |
31,068,233 | Place of death and other factors associated with unnatural mortality in patients with serious mental disorders: population-based retrospective cohort study. | Patients with serious mental disorders have poorer healthcare outcomes at the end of life and are at greater risk of dying from unnatural causes.AimsTo explore place of death and demographic and clinical correlates of unnatural causes of death in patients with serious mental disorders. | BJPsych open | 2,019 | 3 | 1 | 7 |
27,466,343 | SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. | Proteolytic generation of amyloidogenic amyloid β (Aβ) fragments from the amyloid precursor protein (APP) significantly contributes to Alzheimer's disease (AD). Although amyloidogenic APP proteolysis can be affected by trafficking through genetically associated AD components such as SORLA, how SORLA functionally intera... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,016 | 7 | 3 | 29 |
27,640,074 | Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease. | A shared genetic susceptibility between cutaneous malignant melanoma (CMM) and Parkinson's disease (PD) has been suggested. We investigated this by assessing the contribution of rare variants in genes involved in CMM to PD risk. We studied rare variation across 29 CMM risk genes using high-quality genotype data in 6875... | Neurobiology of aging | 2,016 | 12 | 1 | 14 |
25,981,149 | HRS/NSA 2014 survey of atrial fibrillation and stroke: Gaps in knowledge and perspective, opportunities for improvement. | The prevalence of atrial fibrillation (AF) is substantial and increasing. Stroke is common in AF and can have devastating consequences. Oral anticoagulants are effective in reducing stroke risk, but are underutilized. | Heart rhythm | 2,015 | 8 | 1 | 14 |
31,015,294 | Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song. | Performing a stereotyped behavior successfully over time requires both maintaining performance quality and adapting efficiently to environmental or physical changes affecting performance. The bird song system is a paradigmatic example of learning a stereotyped behavior and therefore is a good place to study the interac... | Proceedings of the National Academy of Sciences of the United States of America | 2,019 | 5 | 0 | 13 |
33,219,004 | Assessing the Role of Corticothalamic and Thalamo-Accumbens Projections in the Augmentation of Heroin Seeking in Chronically Food-Restricted Rats. | Drug addiction is a chronic disorder characterized by compulsive drug seeking, and involves repetitive cycles of compulsive drug use, abstinence, and relapse. In both human and animal models of addiction, chronic food restriction increases rates of relapse. Our laboratory has reported a robust increase in drug seeking ... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,021 | 1 | 7 | 17 |
22,964,514 | Disease mechanisms in MS: phases of disease improvement unrelated to relapses. | Natural history of multiple sclerosis includes phases of relapse, remission and insidious progression. New data show that sustained improvements in disease, defined by reductions in EDSS scores, occur independent of relapses almost half as frequently as disease worsening. This finding might facilitate research into the... | Nature reviews. Neurology | 2,012 | 11 | 0 | 1 |
26,661,417 | Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems. | Retinal dystrophies are a major cause of blindness for which there are currently no curative treatments. Transplantation of stem cell-derived neuronal progenitors to replace lost cells has been widely investigated as a therapeutic option. Another promising strategy would be to trigger self-repair mechanisms in patients... | Developmental dynamics : an official publication of the American Association of Anatomists | 2,016 | 7 | 8 | 64 |
31,808,207 | Cerebral small vessel disease with hemorrhagic stroke related to COL4A1 mutation: A case report. | Stroke is a major cause of mortality and morbidity with a wide variety of etiological risk factors. Cerebral small vessel disease (SVD) is an important cause of stroke in the young with several hereditary disorders affecting these small blood vessels. Mutations in the COL4A1 gene (COL4A1) have been shown to be associat... | Neuropathology : official journal of the Japanese Society of Neuropathology | 2,020 | 2 | 2 | 11 |
25,850,619 | Brain rhythms connect impaired inhibition to altered cognition in schizophrenia. | In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified ... | Biological psychiatry | 2,015 | 6 | 7 | 46 |
30,224,452 | Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. | The hippocampus plays a critical role in spatial memory. However, the exact neural mechanisms underlying high-fidelity spatial memory representations are unknown. We report findings from presurgical epilepsy patients with bilateral hippocampal depth electrodes performing an object-location memory task that provided a b... | Proceedings of the National Academy of Sciences of the United States of America | 2,018 | 10 | 6 | 47 |
9,791,092 | Vigilance states and body temperature during the circadian cycle in fed and fasted pigeons (Columba livia). | Fasting induces nocturnal hypothermia in pigeons. Slow-wave sleep (SWS) and paradoxical sleep (PS) are associated with reduced heat production in pigeons. The possibility that fasting-induced nocturnal hypothermia is related to increased SWS and PS was examined by comparing body temperature (Tb) and vigilance states wh... | The American journal of physiology | 1,998 | 11 | 0 | 7 |
29,684,289 | Lonely young adults in modern Britain: findings from an epidemiological cohort study. | The aim of this study was to build a detailed, integrative profile of the correlates of young adults' feelings of loneliness, in terms of their current health and functioning and their childhood experiences and circumstances. | Psychological medicine | 2,019 | 1 | 10 | 191 |
18,486,703 | Outcome of 2 different types of operative techniques practiced for chronic subdural hematoma in Malaysia: an analysis. | Traumatic chronic subdural hematomas in Malaysia are increasingly common in young patients after road traffic accidents as well as the elderly who fall at home. Most surgeons in this country manage these pathologies without irrigation, with only a drainage system. This has led to criticism that the recurrence rate migh... | Surgical neurology | 2,008 | 6 | 0 | 9 |
24,852,228 | Corticolimbic connectivity as a possible biomarker for bipolar disorder. | Bipolar disorder is a severe, disabling and life-threatening illness, which affects nearly 2% of the general population. The identification of reliable and objective biomarkers may aid early diagnosis and optimize treatment efficacy. Through a careful overview of the neuroimaging studies which investigated the structur... | Expert review of neurotherapeutics | 2,014 | 6 | 3 | 26 |
32,942,699 | Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn's Disease. | There is an association between food additive emulsifiers and the prevalence of Crohn's disease. This study aimed to investigate: (i) the effect of different classes of emulsifiers on markers of intestinal inflammation in mice and (ii) the feasibility, nutritional adequacy and symptom impact of restricting all emulsifi... | Nutrients | 2,020 | 9 | 7 | 39 |
32,636,358 | Designing m-Health interventions for precision mental health support. | Mobile health (m-Health) resources are emerging as a significant tool to overcome mental health support access barriers due to their ability to rapidly reach and provide support to individuals in need of mental health support. m-Health provides an approach to adapt and initiate mental health support at precise moments,... | Translational psychiatry | 2,020 | 7 | 3 | 56 |
27,063,782 | Position Sense in Chronic Pain: Separating Peripheral and Central Mechanisms in Proprioception in Unilateral Limb Pain. | Awareness of limb position is derived primarily from muscle spindles and higher-order body representations. Although chronic pain appears to be associated with motor and proprioceptive disturbances, it is not clear if this is due to disturbances in position sense, muscle spindle function, or central representations of ... | The journal of pain | 2,016 | 7 | 1 | 3 |
30,836,779 | Gold nanoparticles and hepatitis B virus. | Hepatitis B virus (HBV) infection is one of the major health issues in the world presently with high tendency of leading to hepatocarcinoma, cirrhosis, and liver cancer, especially if not properly managed. It has been estimated that there are about 2 billion people with a serological profile of HBV infection, and 360 m... | Artificial cells, nanomedicine, and biotechnology | 2,019 | 12 | 1 | 16 |
35,521,095 | The simultaneous detection of the squamous cell carcinoma antigen and cancer antigen 125 in the cervical cancer serum using nano-Ag polydopamine nanospheres in an SERS-based lateral flow immunoassay. | The accurate analysis of tumor related biomarkers is extremely critical in the diagnosis of the early stage cervical cancer. Herein, we designed a novel and inexpensive surface-enhanced Raman scattering-based lateral flow assay (SERS-based LFA) strip with a single test line, which was applied for the rapid and sensitiv... | RSC advances | 2,020 | 8 | 1 | 24 |
29,229,397 | Di-acetyl creatine ethyl ester, a new creatine derivative for the possible treatment of creatine transporter deficiency. | Creatine is pivotal in energy metabolism of the brain. In primary creatine deficiency syndromes, creatine is missing from the brain. Two of them (AGAT and GAMT deficiency) are due to impaired creatine synthesis, and can be treated by creatine supplementation. By contrast, creatine transporter deficiency cannot be treat... | Neuroscience letters | 2,018 | 2 | 1 | 9 |
30,782,625 | XCalibur aneurysm occlusion device for the treatment of direct carotid cavernous fistula: expansion of armamentarium. | We report the first case of a post-traumatic direct carotid cavernous fistula (CCF) treated with the XCalibur aneurysm occlusion device, which is a balloon mounted stent with flow diversion effect. Two devices were deployed across the fistula in an overlapping manner, resulting in complete occlusion of the fistula. Flo... | BMJ case reports | 2,019 | 2 | 0 | 5 |
23,407,949 | HTR2 receptors in a songbird premotor cortical-like area modulate spectral characteristics of zebra finch song. | Serotonin [5-hydroxytryptamine (5-HT)] is involved in modulating an array of complex behaviors including learning, depression, and circadian rhythms. Additionally, HTR2 receptors on layer V pyramidal neurons are thought to mediate the actions of psychedelic drugs; the native function of these receptors at this site, ho... | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,013 | 2 | 1 | 4 |
32,439,021 | Neurodevelopmental Factors in Schizophrenia. | The onset of schizophrenia is usually in late adolescence or early adulthood. However, accumulating evidence has suggested that the disease condition is an outcome of gene-environment interactions that act in neural development during early life and adolescence. Some children who later develop schizophrenia have early ... | The Psychiatric clinics of North America | 2,020 | 6 | 7 | 46 |
28,079,757 | Pathogenesis of abdominal pain in bowel obstruction: role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells. | Abdominal pain is one of the major symptoms in bowel obstruction (BO); its cellular mechanisms remain incompletely understood. We tested the hypothesis that mechanical stress in obstruction upregulates expression of nociception mediator nerve growth factor (NGF) in gut smooth muscle cells (SMCs), and NGF sensitizes pri... | Pain | 2,017 | 4 | 4 | 22 |
30,894,142 | Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation. | We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP). | BMC neurology | 2,019 | 3 | 1 | 8 |
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