pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
16,876,852 | Is pattern of invasion of prognostic value in surgically treated cervical cancer patients? | {
"contexts": [
"Different patterns of invasion (representing different grades of tumor cell dissociation) are associated with prognostic outcome in cancer. We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX).",
"Six hundred eleven surgically treated CX (FIGO I... | Spray-like PI (i.e., highest degree of tumor cell dissociation) is associated with advanced tumor stages, increased rate of recurrency and a reduced overall survival. In separate analysis of patients with and without lymph node metastases, the impact of PI persisted only in node-negative cases as a prognostic factor. | yes |
16,856,902 | Is benefit of `` one-stage full-mouth disinfection '' explained by disinfection and root planing within 24 hours : a randomized controlled trial? | {
"contexts": [
"The beneficial effects of the one-stage, full-mouth disinfection remain controversial in the scientific literature. This might be due to the fact that an entire mouth disinfection with the use of antiseptics has been confused with a full-mouth scaling and root planing. This parallel, single blind... | These observations indicate that the benefits of the "OSFMD" protocol are partially due to the use of the antiseptics and partially to the completion of the therapy in a short time. | yes |
16,869,820 | Is in-hospital cardiac arrest associated with use of non-antiarrhythmic QTc-prolonging drugs? | {
"contexts": [
"QTc interval-prolonging drugs have been linked to cardiac arrhythmias, cardiac arrest and sudden death. In this study we aimed to quantify the risk of cardiac arrest associated with the use of non-antiarrhythmic QTc-prolonging drugs in an academic hospital setting.",
"We performed a case-cont... | Use of non-antiarrhythmic QTc-prolonging drugs in hospitalized patients with several underlying disease is associated with an increased risk of cardiac arrest. The effect is dose related and pharmacokinetic drug-drug interactions increase the risk substantially. Physicians caring for inpatients should be made aware of ... | yes |
16,850,254 | Is a brain-behaviour initiative for South Africa : the time right? | {
"contexts": [
"Many have advocated for science and health research in developing world settings. However, there has been less focus on the value of basic and clinical neuroscience research in this context. The current paper focuses on the relevance of a brain-behaviour research initiative in South Africa.",
... | There is a need to apprise policy-makers in developing world countries such as South Africa of the need for increased expenditure on basic and clinical neuroscience research. Local and international collaboration may be useful in increasing research capacity in South Africa, and ultimately in improving mental health se... | yes |
16,857,795 | Is megakaryocyte potentiation factor cleaved from mesothelin precursor a useful tumor marker in the serum of patients with mesothelioma? | {
"contexts": [
"To establish monoclonal antibodies (mAb) against megakaryocyte potentiation factor (MPF) and detect MPF in the blood of patients with mesothelioma.",
"Mice were immunized with a purified recombinant human MPF-rabbit-Fc fusion protein and with MPF. Several hybridomas producing mAbs to MPF were... | Using new mAbs to MPF, we showed that MPF is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of MPF may be useful in following the response of mesothelioma to treatment. | yes |
16,857,797 | Is high WT1 expression associated with very poor survival of patients with osteogenic sarcoma metastasis? | {
"contexts": [
"Although metastasis is the primary determinant of poor survival of patients with osteogenic sarcoma, some patients live much longer than others, indicating metastatic heterogeneity underlying survival outcome. The purpose of the investigation was to identify genes underlying survival outcome of p... | WT1 seems to be associated with very poor survival of patients with osteogenic sarcoma metastasis. | yes |
16,857,799 | Is an immunohistochemical study of morules in endometrioid lesions of the female genital tract : CD10 a characteristic marker of morular metaplasia? | {
"contexts": [
"To analyze immunohistochemically morules in endometrioid lesions to show that CD10 is a sensitive marker for morular metaplasia.",
"Immunohistochemical analysis of 53 instances of morular metaplasia comprising 1 cyclic endometrium and 52 endometrioid lesions associated with focal glandular co... | CD10 staining represents a useful marker of morules in endometrioid neoplasms of the female genital tract, permitting identification of lesions usually associated with an attenuated malignancy. Considering the immunohistochemical and genetic similarities of morules in tumors of different organs, it is likely that this ... | yes |
16,864,105 | Does [ Bevacizumab ( Avastin ) inhibit lung cancer-induced pulmonary microvascular angiogenesis ]? | {
"contexts": [
"To study the effect of bevacizumab (Avastin) on pulmonary microvascular angiogenesis induced by lung cancer.",
"The effects of Avastin on cell growth, cell cycle and apoptosis of lung microvascular endothelial cells were assayed by flow cytometry.",
"Avastin inhibited the growth of lung m... | Avastin can inhibit the growth and induce apoptosis of lung microvascular endothelial cells in three-dimensional culture, possibly in association with cell cycle arrest in G(0/1) phase. | yes |
16,877,460 | Does lymphoid neogenesis in juvenile idiopathic arthritis correlate with ANA positivity and plasma cells infiltration? | {
"contexts": [
"The aim of the study was to evaluate the pattern of the lymphoid organization in the synovial tissue of patients affected with juvenile idiopathic arthritis (JIA).",
"A total of 40 JIA patients who underwent synoviectomy or synovial biopsies were enrolled. The mean age at surgery was 15.1 yrs... | Lymphoid neogenesis in JIA represents a phase in the immunopathological process that characterize the development of inflammatory synovitis. It is not related to disease activity or severity, but appears to be more frequent in patients with circulating anti-nuclear antibodies. | yes |
16,877,464 | Does imaging predict the clinical outcome of bacterial vertebral osteomyelitis? | {
"contexts": [
"Magnetic resonance imaging (MRI) and computed tomography (CT) are useful for initial assessment of bacterial spondylodiscitis. However, clinical relevance of imaging changes during treatment is less well-documented.",
"Between October 1997 and March 2005, 29 patients with documented bacterial... | Imaging abnormalities often persist in patients with bacterial spondylodiscitis despite a favourable clinical and biological response to antibiotic treatment. They are not associated with relapses, neurological sequelae or persistent pain. Imaging controls are not necessary when bacterial spondylodiscitis responds favo... | no |
16,877,466 | Is sjogren 's syndrome associated with and not secondary to systemic sclerosis? | {
"contexts": [
"When Sjögren's syndrome (SS) is secondary to rheumatoid arthritis, the sicca syndrome is less serious and anti-SSA/SSB antibodies are found less frequently than in primary SS (pSS). When SS is associated with systemic lupus erythematosus, clinical and serological patterns are similar to those of ... | SS seems to be associated with and not secondary to SSc. SS associated with SSc has the same features as pSS, but SSc seems to be less serious. Moreover, the association of SS and SSc is frequently accompanied by a spreading of autoimmunity. | yes |
16,877,991 | Are alanine amino transferase concentrations linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls? | {
"contexts": [
"The objective of this study was to investigate the consequences of low dietary folate intake and the impact of the 677 C-->T methylenetetrahydrofolate reductase (MTHFR) common mutation on liver function in obese adolescents.",
"Fifty-seven obese girls (BMI = 36.1 +/- 6.0 kg/m) aged 14.1 +/- 1... | Our data suggest that folate intake and the MTHFR polymorphism represent a part of the link between antioxidant status and liver disease in obese adolescent girls. | yes |
16,879,220 | Is cLOCK involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression? | {
"contexts": [
"An increased level of obesity-induced plasma plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular disease.",
"The present study investigates whether the circadian clock component CLOCK is involved in obesity-induced PAI-1 elevation.",
"We examined plasm... | These observations suggest that CLOCK is involved in obesity-induced disordered fibrinolysis by regulating PAI-1 gene expression in a tissue-dependent manner. Furthermore, it appears that obesity-induced PAI-1 production in adipose tissue is not closely related to systemic PAI-1 increases in vivo. | yes |
16,879,222 | Does the complement component C5a induce the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation? | {
"contexts": [
"Atherosclerosis is considered to be a chronic inflammatory disorder. Activation of the complement cascade is a major aspect of chronic inflammatory diseases. Complement components were identified in atherosclerotic plaques, and a correlation between adverse events and C5a plasma levels was found.... | We conclude that C5a upregulates PAI-1 in macrophages via NF-kappaB activation. We hypothesize that - if operative in vivo- this effect could favor thrombus development and thrombus stabilization in the lesion area. On the other hand one could speculate that C5a-induced upregulation of PAI-1 in plaque macrophages could... | yes |
16,863,783 | Do changes in cerebral vascular reactivity occur early during cardiopulmonary bypass in the rat? | {
"contexts": [
"Cardiopulmonary bypass (CPB) is known to cause cerebrovascular dysfunction. The etiology of these complications is complex, but disruption of normal cerebral endothelial function as a consequence of inflammatory or hypoperfusion phenomena have been implicated. The aim of this study was to investi... | Cerebrovascular impairment appears early after the onset of CPB. The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction rather than impaired vascular smooth muscle response to nitric oxide. This loss of endothelium-dependent regulatory factors after CPB may enhance vasoconstrictio... | yes |
16,857,247 | Does icodextrin enhance survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy? | {
"contexts": [
"Icodextrin, a novel glucose polymer solution utilized for peritoneal dialysis, has been demonstrated to have prolonged intraperitoneal (IP) instillation volumes in comparison to standard PBS solutions. In an animal model of ovarian cancer, we explored whether a survival advantage exists utilizing... | These experiments suggest that the use of dialysates such as icodextrin may further enhance the therapeutic effects of novel IP virotherapy and other gene therapy strategies for ovarian cancer. Phase I studies utilizing icodextrin-based virotherapy for ovarian cancer are currently in development. | yes |
16,864,980 | Does interaction of endothelin with renal nerves modulate kidney function in spontaneously hypertensive rats? | {
"contexts": [
"We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re... | Since renal papillary endothelin-1 appears to counteract the fluid and sodium retaining effects of renal nerve activity, an impaired renal endothelin-1 synthesis in SHR may contribute to excessive sodium retention and thus to the pathogenesis of hypertension in SHR. | yes |
16,849,406 | Is lower bone mineral content in children with type 1 diabetes mellitus linked to female sex , low insulin-like growth factor type I levels , and high insulin requirement? | {
"contexts": [
"Studies on bone mineral characteristics in children with type 1 diabetes mellitus (T1DM) have generated conflicting results.",
"Our objective was to investigate bone mineral characteristics in children with T1DM and to analyze their associations with bone metabolism and the IGF-I system.",
... | A sex-related difference in the impairment of bone mineral characteristics was identified in children with T1DM. Longitudinal studies are required to investigate whether boys may gain slightly less bone mass during skeletal growth. | yes |
16,855,767 | Does testosterone decrease adiponectin levels in female to male transsexuals? | {
"contexts": [
"To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients.",
"We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female pa... | T can significantly reduce adiponectin serum levels in transsexual female patients. | yes |
16,858,222 | Does regular physical activity increase glutathione peroxidase activity in adolescents with Down syndrome? | {
"contexts": [
"The present study was designed to determine the influence of a 12-week exercise program on the activity of erythrocyte glutathione peroxidase (GPX) in adolescents with Down syndrome.",
"An interventional study with before-after comparison.",
"Sport Medicine School, University of Cadiz (An... | Regular exercise increased significantly GPX activity. Further studies are required to assess the behavior of other antioxidant enzymes to highlight potential benefits of regular exercise in redox metabolism. | yes |
16,863,715 | Do food group adherence scores assess food patterns compared to US Department of Agriculture Food Guide? | {
"contexts": [
"The purpose of this study was twofold: (a) develop and test the potential usefulness of a new measure of dietary adherence to the US Department of Agriculture (USDA) Food Guide and (b) use this measure to assess the diets of children in the United States.",
"Using 2 days of food intake data f... | Results suggest adherence to the USDA Food Guide decreases with increasing age in young children in the United States. Adherence scores may be a useful tool to describe adherence to the new USDA Food Guide. These scores could be used in program evaluation, surveillance, and epidemiological studies of diet and health. | yes |
16,867,914 | Is mTHFR C677T polymorphism associated with placental abruption or preeclampsia in Finnish women? | {
"contexts": [
"The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia.",
"362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were ... | MTHFR C677T polymorphism does not have a major role in the development of preeclampsia or placental abruption in the Finnish population. | no |
16,867,917 | Does chronic nitric oxide synthase inhibition in pregnant rats result in placental oxidative stress? | {
"contexts": [
"This investigation examined the physiological and biochemical changes in pregnant rats following treatment with the nitric oxide synthase inhibitor, L nitroarginine methyl ester (L-NAME).",
"Pregnant and non-pregnant animals were administered L-NAME, and blood pressure and proteinuria were mo... | The L-nitroarginine methyl ester model of experimental preeclampsia induces a number of the physiological characteristics typical of the human disease however fails to initiate biochemical changes in the placenta that occur during human preeclampsia. | no |
16,876,132 | Do catechol-O-methyltransferase ( COMT ) gene variants predict response to bupropion therapy for tobacco dependence? | {
"contexts": [
"Although bupropion is efficacious for smoking cessation, only a minority of smokers are able to quit. Pharmacogenetic research may improve treatment outcomes through discovery of DNA sequences predictive of successful pharmacotherapy for subgroups of smokers. We investigated variants in the catec... | COMT haplotypes at rs737865 and rs165599 may predict a favorable outcome for bupropion treatment for smoking cessation. European-American smokers with a G allele at both SNPs may not benefit from bupropion treatment. Small numbers of some COMT haplotypes limit interpretation of response. If study findings are confirmed... | yes |
16,876,136 | Does prenatal cannabis exposure increase heroin seeking with allostatic changes in limbic enkephalin systems in adulthood? | {
"contexts": [
"Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing.",
"We used an animal model to study the effects of prenatal exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin... | This study demonstrates enduring effects of prenatal THC exposure into adulthood that is evident on heroin-seeking behavior during extinction and allostatic changes in mesocorticolimbic PENK systems relevant to drug motivation/reward and stress response. | yes |
16,871,360 | Is increased superoxide anion production associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model? | {
"contexts": [
"Hypercholesterolemia (HC) has been associated with impairment of vascular and myocardial functions. As HC could generate an alteration in the oxidative status, we studied the effects of a 1-month cholesterol diet on cardiovascular oxidative stress.",
"New Zealand rabbits received cholesterol ... | Hypercholesterolemia induced increased levels of superoxide in the aortas and a higher expression of NOX subunits, associated with altered vasorelaxation. The increased diastolic pressure observed in hearts, consistent with a post-ischemic contractile dysfunction might be mediated by the production of superoxide. | yes |
16,860,806 | Do indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease? | {
"contexts": [
"Indian Asians have high rates of heart disease and stroke, but risks of peripheral arterial disease appear to be low. This paradox, and reasons for it, have not been explored. We compared ethnic differences in peripheral arterial disease for a given level of coronary disease.",
"We studied 83... | For a given level of coronary disease, Indian Asians have less lower limb atherosclerosis than Europeans, unexplained by established risk factors. Further study of these populations would help tease out relative contributions of risk factors to atherosclerosis in different vessel beds. | yes |
16,859,664 | Does cholesteryl ester transfer protein promote the formation of cholesterol-rich remnant like lipoprotein particles in human plasma? | {
"contexts": [
"Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma.",
"Human plasma was incubated with or without HDL containing [(3)H]-l... | CETP promotes the formation of cholesterol-rich RLP through the transfer of CE from HDL to TRL and CETP inhibitors are useful to reduce RLP-C. | yes |
16,868,172 | Is portal vein ligation as effective as sequential portal vein and hepatic artery ligation in inducing contralateral liver hypertrophy in a rat model? | {
"contexts": [
"Dual embolization of the hepatic artery and portal vein (PV) has been proposed to enhance contralateral liver regeneration before resection. The aim of this study was to evaluate the effect of PV ligation compared with simultaneous or sequential dual ligation on regeneration, proinflammatory resp... | PV ligation is as effective as dual ligation in inducing liver regeneration. No additional benefit of arterial ligation was observed. | yes |
16,861,949 | Does l-arginine improve endothelial and myocardial function after brain death? | {
"contexts": [
"Recently, we showed that brain death (BD) leads to a severe impairment of endothelial function.",
"To test the hypothesis, that nitric oxide supply improves endothelial function, we infused L-arginine (40 mg/kg) in 6 dogs after BD induction (subdural balloon). Six vehicle-treated BD animals s... | L-arginine treatment prevents endothelial dysfunction and improves myocardial performance after BD via enhancement of endogenous nitric oxide synthesis. | yes |
16,861,948 | Are mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications associated with renal transplant graft failure? | {
"contexts": [
"Mycophenolate mofetil (MMF) use in renal transplantation has steadily increased since 1995 because of its ability to lower the risks of rejection and chronic allograft nephropathy. However, significant gastrointestinal (GI) complications may lead to MMF dose reductions and discontinuations. Littl... | Renal transplant recipients who underwent MMF dose reduction or withdrawal following GI diagnosis are associated with increased risk of graft failure. | yes |
16,864,728 | Does neutralization of interleukin-18 inhibit neointimal formation in a rat model of vascular injury? | {
"contexts": [
"Studies in humans and animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization. Higher IL-18 plasma levels also are associated with restenosis after co... | These results identify a critical role for IL-18 in neointimal formation in a rat model of vascular injury and suggest a potential role for IL-18 neutralization in the reduction of neointimal development. | yes |
16,864,729 | Does sCN5A polymorphism restore trafficking of a Brugada syndrome mutation on a separate gene? | {
"contexts": [
"Brugada syndrome is associated with a high risk of sudden cardiac death and is caused by mutations in the cardiac voltage-gated sodium channel gene. Previously, the R282H-SCN5A mutation in the sodium channel gene was identified in patients with Brugada syndrome. In a family carrying the R282H-SCN... | This study suggests a mechanism whereby the Brugada syndrome has incomplete penetrance. More importantly, this study suggests that genetic polymorphisms may be a potential target for future therapies aimed at rescuing specific dysfunctional protein channels. | yes |
16,864,727 | Does deletion of p47phox attenuate angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice? | {
"contexts": [
"Angiotensin II (Ang II) contributes to vascular pathology in part by stimulating NADPH oxidase activity, leading to increased formation of superoxide (O2-). We reported that O2- levels, NADPH oxidase activity, and expression of the p47phox subunit of NADPH oxidase are increased in human abdominal... | Deletion of p47phox attenuates Ang II-induced AAA formation in apoE-/- mice, suggesting that NADPH oxidase plays a critical role in AAA formation in this model. | yes |
16,870,239 | Are radiation-associated endometrial cancers prognostically unfavorable tumors : a clinicopathologic comparison with 527 sporadic endometrial cancers? | {
"contexts": [
"Previous reports have suggested that patients who have undergone pelvic radiation for cervical cancer are at risk for developing poorly differentiated endometrial cancers with poor prognoses.",
"We conducted a retrospective chart and histologic review of patients from Memorial Sloan-Kettering... | The clinicopathologic characteristics of RAECs, which include a preponderance of high-stage, high-grade and high-risk histologic subtypes, indicate that these tumors differ from sporadic endometrial carcinomas. However, patients with RAECs do not appear to have a significantly worse prognosis when compared with patient... | yes |
16,868,055 | Does recombinant human thyrotropin reduce endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma? | {
"contexts": [
"We evaluated endothelial-dependent vasodilation after administration of recombinant human TSH (rhTSH) in patients monitored for differentiated thyroid carcinoma. The role of inflammation and oxidative stress was also assessed.",
"Twenty-four patients (21 women, mean age 40.5 +/- 9.2 yr) recei... | rhTSH administration acutely impaired endothelium-dependent vasodilation, possibly through the induction of low-grade inflammation and reduced nitric oxide availability by oxidative stress. | yes |
16,864,964 | Does interleukin-6 correlate with endothelial dysfunction in young post-myocardial infarction patients? | {
"contexts": [
"The estimation of coronary risk based on consideration of classical risk factors is insufficient in young patients with myocardial infarction who have low expressions of classical risk factors. Endothelial dysfunction (ED) and markers of vascular inflammation may be more appropriate for risk esti... | It appears that IL-6 is the most valuable circulating marker of ED, and consequently a useful marker of coronary risk. | yes |
16,864,966 | Does anti-inflammatory treatment with standardized human serum protein solution reduce local and systemic inflammatory response after hemorrhagic shock? | {
"contexts": [
"Reperfusion after hemorrhagic shock leads to local and systemic inflammatory response. This study evaluates the effect of a short-term treatment with standardized human serum protein solution (SPS) on the local and systemic inflammatory response in the mesenteric microcirculation in the rat.",
... | Short-term SPS treatment of hemorrhagic shock improved mesenteric microcirculation, arterial blood gases and global hemodynamics, and attenuated the inflammatory response to reperfusion. It may provide clinical benefit when applied at an early phase of reperfusion after hemorrhagic shock. | yes |
16,875,509 | Is the E670G SNP in the PCSK9 gene associated with polygenic hypercholesterolemia in men but not in women? | {
"contexts": [
"Common genetic variants in the PCSK9 gene have been reported to be associated with both elevated and exceptionally low LDL levels. The association of a common haplotype, encompassing the E670G single nucleotide polymorphism, with LDL levels reported by Chen et al (J Am Coll Cardiol 2005; 45: 1644... | In a European population the E670G SNP in the PCSK9 gene is associated with increased LDL in men but not in women. | yes |
16,877,473 | Does admission ECG predict long-term outcome in acute coronary syndromes without ST elevation? | {
"contexts": [
"Acute coronary syndromes (ACS) without ST elevation are a frequent cause of hospital admission, myocardial infarction and death.",
"To explore the role of the ECG in stratifying ACS patients.",
"Prospective, centrally-coordinated multicentre registry involving 56 centres throughout the UK... | Rates of adverse events are high in patients admitted to UK hospitals with ACS without ST elevation. The ECG remains a very important and simple discriminator of both short- and long-term risk, enabling more aggressive, proven therapies to be targeted towards those at highest risk. | yes |
16,855,388 | Is the BRK tyrosine kinase expressed in high-grade serous carcinoma of the ovary? | {
"contexts": [
"We identified the BRK tyrosine kinase in a PCR-based screen of tyrosine kinases expressed by ovarian tumors. BRK expression is restricted to normal differentiating epithelial cells and its overexpression may play a role in processes related to tumor development and growth. Its expression in norma... | The amplification of the BRK gene and overexpression of BRK protein in the majority of high-grade serous carcinomas and ovarian cancer cell lines suggest that BRK may play a role in the development and growth of ovarian tumors. | yes |
16,874,014 | Is combined biodifferentiating and antiangiogenic oral metronomic therapy feasible and effective in relapsed solid tumors in children : single-center pilot study? | {
"contexts": [
"To outline an outpatient-based treatment for children with relapsed solid tumors, who already have been extensively pretreated, we defined a 4-drug protocol named COMBAT (combined oral maintenance biodifferentiating and antiangiogenic therapy). Using this protocol, we performed a pilot study to d... | The COMBAT regimen is well tolerated by patients with intensive prior therapy including myeloablative regimens. Favorable responses observed in this cohort of patients support the further exploration of this and/or similar strategies in the treatment of pediatric solid tumors. | yes |
16,858,739 | Is cord insertion into the lower third of the uterus in the first trimester associated with placental and umbilical cord abnormalities? | {
"contexts": [
"To assess the feasibility of detecting the cord insertion site during the late first trimester, and to investigate the possible association between perinatal complications and a cord insertion in the lower third of the uterus in the first trimester.",
"This was a prospective cohort study in w... | Developmental abnormalities of the placenta and umbilical cord occur frequently in cases in which the cord insertion is in the lower third of the uterus in the first trimester. We suggest that screening for the cord insertion site at 9-11 weeks of gestation may have clinical significance for predicting abnormalities of... | yes |
16,866,724 | Is cerebral vasoreactivity influenced by the prandial state among migraineurs? | {
"contexts": [
"To test if the cerebral vasoreactivity among migraineurs is influenced by the prandial state.",
"Eight patients with migraine without aura were studied (mean age = 23.75 years; range = 19 to 32 years; 6 women). We also studied 8 healthy controls (mean age = 20.63 years; range = 18 to 22 years... | Our findings suggest that migraineurs have a higher reactivity to hypercapnia during the PP period. | yes |
16,856,823 | Is fetal brain sparing strongly related to the degree of increased placental vascular impedance? | {
"contexts": [
"Doppler ultrasound examination has become an established method of clinical surveillance in high-risk pregnancies. Doppler indication of fetal brain sparing (BS) is an acknowledged sign of circulation redistribution during chronic hypoxia.",
"To evaluate the relationship between placental vas... | A clear correlation exists between increasing placental vascular impedance and BS in the MCA. Preterm pregnancies express the greatest deviation from the mean MCA PI. | yes |
16,878,082 | Is systemic white blood and endothelial cell response after revascularization of critical limb ischemia only influenced in case of ischemic ulcers? | {
"contexts": [
"The aim of this study was to study the inflammatory response to open revascularization of an ischemic leg in terms of activation of white blood cells (WBC), platelets and endothelial cells.",
"prospective study.",
"Venous samples from 21 patients suffering critical limb ischemia (CLI) wer... | This study shows that revascularization of CLI does not significantly influence the inflammatory response in patients with rest pain only, but a limited response of down regulation was found in the ulcer/gangrene patients probably as an effect of healing ulcers. | yes |
16,863,711 | Are low-energy-density diets associated with high diet quality in adults in the United States? | {
"contexts": [
"This study investigated food choices made by individuals consuming diets differing in energy density and explores relationships between energy density and diet quality.",
"Cross-sectional, nationally representative survey.",
"7,500 adults (older than 19 years) in the 1994-1996 Continuing ... | These analyses further demonstrate the beneficial effects of a low-energy-density diet, which was associated with lower energy intakes, higher food intakes, and higher diet quality than a high-energy-density diet. To achieve a low-energy-density diet, individuals should be encouraged to eat a variety of fruits and vege... | yes |
16,864,099 | Does [ Perivenous support with autologous pericardium inhibit neointimal thickening in canine vein grafts ]? | {
"contexts": [
"To observe the effect of perivenous support with autologous pericardium on neointimal thickening in canine vein grafts.",
"An autologous pericardium graft of 7 cm x 4 cm was harvested in right anterolateral thoracotomy. Two equal segments of the jugular vein were transplanted to both sides of... | Perivenous support of the vein graft with autologous pericardium can reduce intimal and medial hyperplasia in the graft. | yes |
16,862,679 | Does parent 's Evaluation of Developmental Status ( PEDS ) detect developmental problems compared to Denver II? | {
"contexts": [
"The early detection of developmental and behavioral problems in children is crucial for early intervention. The effectiveness of early detection depends on skills and interest of clinicians. Parents are the precious sources of information. The suspicions of parents about their children's developm... | PEDS could play a role in detection of developmental problems but was not a good tool in screening. Therefore, significant concerns of parents about their children's development are the critical information for referral to have further management. In other words, parents concerns could have far more advantage than the ... | yes |
16,866,576 | Does why reassurance fail in patients with unexplained symptoms -- an experimental investigation of remembered probabilities? | {
"contexts": [
"Providing reassurance is one of physicians' most frequently used verbal interventions. However, medical reassurance can fail or even have negative effects. This is frequently the case in patients with medically unexplained symptoms. It is hypothesized that these patients are more likely than pati... | Physicians should be aware that patients with medically unexplained symptoms recall the likelihood of medical causes for their complaints incorrectly. Therefore, physicians should verify correct understanding by using check-back questions and asking for summaries, to improve the effect of reassurance. | yes |
16,859,551 | Are common variations in ALG9 associated with bipolar I disorder : a family-based study? | {
"contexts": [
"A mannosyltransferase gene (ALG9, DIBD1) at chromosome band 11q23 was previously identified to be disrupted by a balanced chromosomal translocation t(9;11)(p24;q23) co-segregating with bipolar affective disorder in a small family. Inborn ALG9 deficiency (congenital disorders of glycosylation type... | These results suggest that common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder. | no |
16,859,558 | Does iL-2 production correlate with effector cell differentiation in HIV-specific CD8+ T cells? | {
"contexts": [
"Diminished IL-2 production and lack of effector differentiation have been reported for HIV-specific T cells. In this study, we examined the prevalence of these phenomena using 8-color cytokine flow cytometry, and tested the hypothesis that these two findings were causally related. We analyzed cyt... | IL-2 production from antigen-specific CD8+ T cells correlates with effector cell differentiation of those cells. | yes |
16,857,868 | Are microgravity-induced modifications of the vestibuloocular reflex in Xenopus laevis tadpoles related to development and the occurrence of tail lordosis? | {
"contexts": [
"During space flights, tadpoles of the clawed toad Xenopus laevis occasionally develop upward bended tails (tail lordosis). The tail lordosis disappears after re-entry to 1g within a couple of days. The mechanisms responsible for the induction of the tail lordosis are unknown; physical conditions ... | (1) the vestibular system of tadpoles with lordotic tails is developmentally retarded by microgravity; (2) after a critical status of vestibular maturation obtained during the appearance of first swimming, microgravity activates an adaptation mechanism that causes a sensitization of the vestibular system. | yes |
16,869,848 | Is the effect of exercise in reducing desire to smoke and cigarette withdrawal symptoms caused by distraction? | {
"contexts": [
"Moderate-intensity exercise has been shown to reduce common smoking withdrawal symptoms and desire to smoke in acutely abstinent smokers. The aim of the present study was to determine if this was caused by distraction. A secondary aim was to determine whether exercise-related changes in affect we... | A brief bout of moderate-intensity exercise can lead to a rapid reduction in desire to smoke and withdrawal discomfort, which is not due to the distracting effect of exercise or the effects of mood. These findings support recommendations to smokers to use exercise as a means of helping cope with the difficulties encoun... | no |
16,869,845 | Is contingency knowledge necessary for learned motivated behaviour in humans : relevance for addictive behaviour? | {
"contexts": [
"Many forms of human conditioned behaviour depend upon explicit knowledge of the predictive contingency between stimuli, responses and the reinforcer. However, it remains uncertain whether the conditioning of three key behaviours in drug addiction-selective attention, instrumental drug-seeking beh... | The implication of the present findings is that the control of selective attention, instrumental drug-seeking behaviour and emotional state by drug-paired stimuli is mediated by cognitive knowledge of the predictive contingency between the stimulus and the drug. | yes |
16,860,071 | Does endoscopic submucosal dissection allow curative resection of locally recurrent early gastric cancer after prior endoscopic mucosal resection? | {
"contexts": [
"Repeat endoscopic mucosal resection (EMR) to cure locally recurrent early gastric cancer (EGC) is difficult to perform because the initial EMR causes submucosal fibrosis; however, ESD allows submucosal dissection through the fibrosis and provides an en bloc specimen.",
"The objective was to d... | The limitation of the study was retrospective design. | yes |
16,860,074 | Does patient feedback on helpfulness of postal information pack regarding informed consent for endoscopic procedures? | {
"contexts": [
"Informed consent is an important part of any medical procedure.",
"Our objective was to assess the impact of postal information on the understanding of consenting for gastrointestinal endoscopy.",
"Cross-sectional survey.",
"District hospital, United Kingdom.",
"A total of 1800 pa... | Lack of literacy check and suboptimal subject participation. | yes |
16,875,718 | Is xRCC1 R399Q polymorphism associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer? | {
"contexts": [
"The aim of the study was to assess whether the genetic polymorphisms were associated with the tumor response in patients treated with platinum-based neoadjuvant chemotherapy (NAC) for bulky cervical cancer.",
"We retrospectively reviewed the clinical data and recruited paraffin-embedded, form... | Genetic polymorphism of XRCC1 R399Q is associated with response to platinum-based NAC in bulky cervical cancer, and MDR analysis documented association between gene-gene interaction of XRCC1 R399Q and treatment response. | yes |
16,856,552 | Do [ The clinical course of microalbumiuria in 4 burn patients ]? | {
"contexts": [
"In burn patients, microvascular permeability is increased. It is difficult to decide the time to administer albumin because it may induce pulmonary edema in the re-filling period. One report shows that microalbuminuria is correlated with endothelial injury and systemic microvascular permeability.... | The present results show that ACR seems to be correlated with the level of microvascular permeability in 4 burn patients. We conclude that ACR may be a useful indicator to decide the time to administer albumin to a burn patient. However, further investigation is required to decide the threshold value of ACR in a severe... | yes |
16,864,825 | Does antiretroviral therapy improve cognitive impairment in HIV+ individuals in sub-Saharan Africa? | {
"contexts": [
"Highly active antiretroviral therapy (HAART) can improve cognitive performance in some patients with HIV-associated cognitive impairment in the United States. The effect of HAART on HIV dementia in sub-Saharan Africa is largely unknown.",
"To evaluate neuropsychological test and functional pe... | Highly active antiretroviral therapy (HAART) can be associated with improvement in neurocognitive and functional performance in HIV+ individuals in sub-Saharan Africa. These results suggest that HAART, if available in areas with limited resources in sub-Saharan Africa, should be provided for patients with HIV-associate... | yes |
16,865,058 | Does aLCAM/CD166 protect breast cancer cells against apoptosis and autophagy? | {
"contexts": [
"Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a 105-kDa transmembrane glycoprotein linked with cell migration and development and with cancer progression (malignant melanoma, prostate cancer and, very recently, breast cancer). This report is the first evaluation of ALCAM/CD166 in an... | The above results indicate that ALCAM-ALCAM interactions are crucial to the survival and primary site maintenance of breast cancer cells. Impaired expression of ALCAM/CD166 is associated with the induction of two types of programmed cell death, apoptosis and autophagy, in breast cancer cells. This adhesion molecule can... | yes |
16,876,559 | Does resistance training improve muscle function and body composition in patients with hyperthyroidism? | {
"contexts": [
"To evaluate the effect of resistance training on skeletal muscle performance and body composition in patients with medically treated hyperthyroidism.",
"Nonrandomized controlled trial.",
"Large public tertiary hospital.",
"Sixteen sedentary patients with recent clinical diagnosis and ... | Resistance training accelerates the recovery of skeletal muscle function and promotes weight gain based on muscle mass improvement in patients with medically treated hyperthyroidism. | yes |
16,877,435 | Is haploinsufficiency the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease? | {
"contexts": [
"Autosomal dominant Stargardt-like (STGD3) disease results from mutations in the ELOVL4 gene (elongation of very-long-chain fatty acids). This study was undertaken to characterize a mouse model with a targeted deletion of Elovl4 and to explore the role of this gene in retinal/macular degeneration.... | The detailed characterization of this animal model provides the first in vivo evidence that Elovl4 haploinsufficiency is not the underlying key disease mechanism in STGD3. The results are consistent with a dominant negative mechanism for the deletion mutation. The Elovl4 knockout mouse is one of three complementary ani... | no |
16,862,820 | Does central plasmid antisense administration reduce blood pressure inhibiting alpha2B adrenoceptor gene expression in spontaneously hypertensive rats in vivo? | {
"contexts": [
"The involvement of central alpha2B adrenoceptors (AR) in the maintenance of hypertension has been proven by a series of previous experiments, at least in a particular model of nephrogenic salt-induced hypertension. The aim of the present study was to investigate further the role of central alpha2... | Central injection of antisense DNA targeting alpha2B mRNA in the genetic model of hypertension of the SHR seems to have a significant hypotensive effect, at least on the first day of injection. The nucleus tractus solitarii seems to be the primary area of action of central alpha2B AR in SHRs. | yes |
16,870,634 | Does exercise-based cardiac rehabilitation improve heart rate recovery in elderly patients after acute myocardial infarction? | {
"contexts": [
"Heart rate recovery (HRR), defined as the fall in HR during the first minute after exercise, is a marker of vagal tone, which is a powerful predictor of mortality in patients with coronary artery disease and in older patients. Whether exercise training (ET) modifies HRR in elderly patients recove... | In older AMI patients, ET results in HRR improvement, which was correlated to the improvement in cardiopulmonary parameters. These findings may shed additional light on the possible mechanisms of the beneficial prognostic effects of ET in this patient population. | yes |
16,854,500 | Does eEG and MRI correlate of mild cognitive impairment and Alzheimer 's disease? | {
"contexts": [
"To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both.",
"Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impair... | EEG and MRI are each associated with different aspects of cognitive function and complement each other in their relations to psychomotor speed. | yes |
16,868,057 | Is the growth response to growth hormone ( GH ) treatment in children with isolated GH deficiency independent of the presence of the exon 3-minus isoform of the GH receptor? | {
"contexts": [
"A variant of the human GH receptor (GHR) lacks a 22-amino-acid sequence derived from exon 3 (d3-GHR). It was reported that pediatric patients, born small for gestational age or with idiopathic short stature who were homozygous or heterozygous for this variant responded better to GH treatment than... | Our results indicate that the d3-GHR allele does not affect response to GH treatment or contribute to growth predictions in patients with IGHD who received replacement doses of GH aiming to restore a normal GH status. We did not confirm the previously reported data obtained in patients small for gestational age or with... | yes |
16,876,130 | Is human choline transporter gene variation associated with corticolimbic reactivity and autonomic-cholinergic function? | {
"contexts": [
"Our previous work has shown genetic variation in the human choline transporter gene (CHT1) to be associated with depressive symptoms and autonomic cardiac (cholinergic) dysregulation. Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide p... | CHT1 variation is related to differences in a distributed corticolimbic circuitry mediating behavioral and physiologic arousal. These relations may contribute to a biological mechanism by which genetic variation in cholinergic neurotransmission affects cognition, mood, and autonomic cardiac function. | yes |
16,860,190 | Does long-term treatment with EPO increase serum levels of high-density lipoprotein in patients with CKD? | {
"contexts": [
"Among lipid abnormalities observed in patients with chronic kidney disease (CKD) is a significant decrease in serum high-density lipoprotein cholesterol (HDL-C) levels. In a previously published randomized control trial, we showed that early erythropoietin (EPO) administration in a predialysis po... | Our results show that EPO treatment of predialysis patients with CKD significantly increases serum HDL-C levels, which may represent an important antiatherogenic effect of this hormone. | yes |
16,864,159 | Does the liquorice effect on the RAAS differ between the genders? | {
"contexts": [
"Liquorice-induced increase in blood pressure (BP) is more profound in subjects with essential hypertension (HT) than in healthy individuals. Liquorice induces pseudohyperaldosteronism by inhibiting the 11beta-hydroxysteroid dehydrogenase type 2 and is also known to inhibit the renin-angiotensin-a... | The liquorice-induced inhibition of aldosterone secretion differs between the genders and is not influenced by the BP levels. This difference between the genders has not been exposed before. | yes |
16,864,157 | Is metabolism of collagen altered in hypertensives with increased intima media thickness? | {
"contexts": [
"Increased intima media thickness (IMT) of common carotid arteries (CCAs) and left ventricular mass index (LVMI) are independent risk factors for vascular events and may be related to accumulation of extracellular proteins due to altered metabolism of collagen.",
"IMT and LVMI were measured ul... | We suggest that the collagenase-anticollagenase system is abnormal in essential hypertension and contributes to cardiovascular remodeling. Increased IMT may be related to the accumulation of extracellular proteins due to altered metabolism of collagen. | yes |
16,862,068 | Do methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma? | {
"contexts": [
"To assess whether or not the c.677C/T and c.1298A/C genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are associated with open angle glaucoma (OAG).",
"Genomic DNA was examined in a cohort of 131 Japanese patients with normal tension glaucoma (NTG), 133 patients wi... | The MTHFR c.677C/T and c.1298A/C polymorphisms were not found to be associated with NTG and POAG. Further studies in the different ethnic populations should be performed to elucidate the relationship between MTHFR and OAG. | yes |
16,879,692 | Does penicillamine administration reverse the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit? | {
"contexts": [
"To elucidate the role of copper in mediating the impact of homocysteine on vasculogenic erectile dysfunction (VED), by investigating the effect of dietary supplementation with the copper-chelator penicillamine to rabbits rendered hyperhomocysteinaemic (HHC) with a methionine-rich diet, as a raise... | These data show that elevated levels in vivo of homocysteine in the rabbit markedly impair NO-dependent relaxation of the CC. Furthermore, this effect appears to be augmented by copper. Further clinical studies on homocysteine and copper status in patients with VED are warranted. | yes |
16,858,527 | Does an angulated common bile duct predispose to recurrent symptomatic bile duct stones after endoscopic stone extraction? | {
"contexts": [
"Endoscopic sphincterotomy and stone extraction are standard procedures for the removal of bile duct stones. Stone recurrence can, however, occur in up to 25% of cases. Risk factors have been poorly defined, but are believed to be related to bile stasis. This study investigated whether an angulate... | Angulation of the CBD (< or = 145 degrees) on endoscopic cholangiography, a dilated CBD, and a previous open cholecystectomy are independent risk factors for symptomatic recurrence of bile duct stones. The findings support the role of bile stasis in stone recurrence. Further studies using these data prospectively to id... | yes |
16,850,145 | Is preoperative positron emission tomography with fluorine-18-fluorodeoxyglucose predictive of prognosis in patients with hepatocellular carcinoma after resection? | {
"contexts": [
"Hepatocellular carcinomas (HCCs) accumulate fluorine-18 fluorodeoxyglucose (FDG) to various degrees. The standardized uptake values (SUVs) of FDG-positron emission tomography (PET) in high-grade HCCs are significantly higher than those in low-grade HCCs.",
"The aim of this study was to evalua... | The SUV ratio was related significantly to disease-related death as well as other predictive factors, including the number of tumors, the size, stage, and involvement of vessels, and the involvement of the capsule. Consequently, we conclude that the SUV ratio provides information of prognostic relevance in patients wit... | yes |
16,869,724 | Are femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross regulated predominantly by genetic loci that regulate bone geometry? | {
"contexts": [
"Genetic analysis of an NZB/B1NJ x RF/J cross has identified QTLs for femur mechanical, geometric, and densitometric phenotypes. Most mechanical QTLs were associated with geometric QTLs, strongly suggesting common genetic regulation.",
"Previous studies have shown that bone architecture and BM... | Genetic regulation of mechanical properties in the F(2) mice of this NZB/B1NJ x RF/J cross seems to be caused by genes regulating femur geometry. | yes |
16,869,727 | Does aDAM12-S stimulate bone growth in transgenic mice by modulating chondrocyte proliferation and maturation? | {
"contexts": [
"ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell-extrac... | ADAM12-S stimulates bone growth in mice by modulating chondrocyte proliferation and maturation through mechanisms probably involving both metalloprotease and adhesion activities. | yes |
16,875,599 | Does [ Bcl-XL antisense oligodeoxynucleotide sensitize human esophageal cancer cell line to 5-fluorouracil ]? | {
"contexts": [
"To investigate the effects of the Bcl-XL antisense oligodeoxynucleotides (ASODN) in suppressing the Bcl-XL expression and increasing the sensitivity of esophageal cancer cell line EC9706 to 5-fluorouracil (5-Fu).",
"The proliferation inhibitory rate of EC9706 was assessed by MTT, the expressi... | Bcl-XL ASODN combined with 5-Fu can effectively inhibit the proliferation of esophageal cancer cells in vitro. Bcl-XL ASODN can significantly increase the sensitivity of esophageal cancer cells to 5-Fu through suppressing the expression of Bcl-XL. | yes |
16,876,733 | Is lipid-lowering drug use associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction? | {
"contexts": [
"Inflammation and oxidative stress have been implicated in the pathogenesis of atrial fibrillation (AF). Lipid-lowering drugs, particularly statins and fibrates, possess anti-inflammatory and antioxidant properties.",
"The purpose of this study was to assess the impact of lipid-lowering drug u... | Use of lipid-lowering drugs in patients with reduced LVEF is associated with a significant reduction in the prevalence of AF independent of the lipid profile and other known arrhythmia risk factors. This effect is larger than that of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers or beta-blocker... | yes |
16,874,645 | Are manual methods suboptimal compared with automated methods for cleaning of single-use biopsy forceps? | {
"contexts": [
"Most reusable biopsy forceps and all of the currently available single-use biopsy forceps do not have a port that allows fluid flow down the inner tubular shaft of the device. Reusable biopsy forceps are widely used and reprocessed in healthcare facilities, and single-use biopsy forceps are repro... | The data from this evaluation indicate that manual and sonication-only cleaning methods for biopsy forceps were totally ineffective in removing material from within the biopsy forceps. Even the use of retroflush cleaning was not totally effective. These findings suggest that in-hospital reprocessing of biopsy forceps w... | yes |
16,865,774 | Does cortex cinnamomi extract prevent streptozotocin- and cytokine-induced beta-cell damage by inhibiting NF-kappaB? | {
"contexts": [
"To clarify the mechanism underlying the anti-diabetic activities of cortex cinnamomi extract (CCE).",
"To induce in vivo diabetes, mice were injected with streptozotocin (STZ) via a tail vein (100 mg STZ/kg body weight). To determine the effects of CCE, mice were administered CCE twice daily ... | The molecular mechanism by which CCE inhibits iNOS gene expression appears to involve the inhibition of NF-kappaB activation. These results reveal the possible therapeutic value of CCE for the prevention of diabetes mellitus progression. | yes |
16,866,209 | Does oral hyaluronan gel reduce post operative tarsocrural effusion in the yearling Thoroughbred? | {
"contexts": [
"Hyaluronan (HA) has been used to treat joint disease via intra-articular, i.v. and oral administration. The efficacy of intra-articular and i.v. use has been evaluated but the oral route has yet to be examined.",
"To determine the effect of oral hyaluronan gel on joint effusion following arth... | Oral preparations of hyaluronan are being used to treat joint disease in horse. Anecdotal reports supporting the efficacy of these preparations already exist. This study provides objective evidence that oral HA reduces joint effusion post operatively following the arthroscopic removal of an OCD lesion in the tarsocrura... | yes |
16,879,219 | Is lipopolysaccharide-induced decreased protein S expression in liver cells mediated by MEK/ERK signaling and NFkappaB activation : involvement of membrane-bound CD14 and toll-like receptor-4? | {
"contexts": [
"The vitamin K-dependent protein S (PS), mainly synthesized in hepatocytes and endothelial cells, plays a critical role in the anticoagulant activity of plasma. The decreased plasma level of PS in sepsis is associated with thrombotic tendency, but the mechanism is unclear.",
"In the present st... | These findings suggest that LPS-induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and NFkappaB activation and that membrane-bound CD14 and TLR-4 are involved in this mechanism. These findings may explain in part the decreased level of plasma PS and thrombotic tendency in sepsis. | yes |
16,857,549 | Does lipid infusion accelerate removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart? | {
"contexts": [
"Infusion of a lipid emulsion has been advocated for treatment of severe bupivacaine cardiac toxicity. The mechanism of lipid rescue is unknown. These studies address the possibility that lipid infusion reduces cardiac bupivacaine content in the context of cardiac toxicity.",
"We compared the ... | Lipid emulsion speeds loss of bupivacaine from cardiac tissue while accelerating recovery from bupivacaine-induced asystole. These findings are consistent with the hypothesis that bupivacaine partitions into the emulsion and supports the concept of a "lipid sink." However, the data do not exclude other possible mechani... | yes |
16,861,611 | Do obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake? | {
"contexts": [
"The administration of the growth hormone (GH) secretagogue GH-releasing peptide (GHRP)-2, like ghrelin, increases food intake (FI) in lean healthy men. The aim of this study was to investigate whether this effect occurs in obese subjects and whether it is dose-dependent.",
"Nineteen subjects ... | The dual stimulatory effect of GHRP-2 on FI and human GH is dose dependent. Obese individuals retain their ability to respond to GHRP-2 both in terms of FI and human GH. | yes |
16,870,888 | Do combination of fetal Doppler velocimetric resistance values predict acidemic growth-restricted neonates? | {
"contexts": [
"This study was undertaken to determine the efficacy of combination Doppler velocimetric resistance values of the umbilical artery and ductus venosus in predicting growth-restricted neonates with acidemia.",
"This retrospective case-control study included 61 gravidas complicated by intrauterin... | Compared with single-vessel assessment, combining the pulsatility indices of the umbilical artery and the pulsatility indices for the vein of the ductus venosus provides the greatest accuracy in predicting growth-restricted neonates with acidemia. | yes |
16,860,738 | Does a command chemical trigger an innate behavior by sequential activation of multiple peptidergic ensembles? | {
"contexts": [
"At the end of each molt, insects shed their old cuticle by performing the ecdysis sequence, an innate behavior consisting of three steps: pre-ecdysis, ecdysis, and postecdysis. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central ner... | Our findings offer novel insights into how a command chemical orchestrates an innate behavior by stepwise recruitment of central peptidergic ensembles. | yes |
16,877,727 | Do risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia? | {
"contexts": [
"The risk factors for treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (AML) after autologous stem-cell transplantation (ASCT) are similar to those that increase the risk of difficult stem-cell harvests. We reviewed our experience in 526 patients with lymphoma trea... | These results suggest that identifiable pretransplantation factors predict for t-MDS/AML after ASCT. | yes |
16,849,976 | Does prevalence and correlate of perineal dermatitis in nursing home residents? | {
"contexts": [
"Perineal dermatitis is an adverse outcome of incontinence, which is common in older nursing home residents; yet knowledge about perineal dermatitis in this population is sorely lacking.",
"To determine the prevalence and significant correlates of perineal dermatitis in older nursing home resi... | Several correlates of perineal dermatitis (mechanical chafing, fecal and double incontinence, and use of restraints) appear modifiable through nursing intervention. Clinical interventions should consider the complex health status of this population. | yes |
16,861,936 | Does rapamycin delays but prevent recovery from acute renal failure : role of acquired tubular resistance? | {
"contexts": [
"We reported that rapamycin impairs recovery after acute renal failure (ARF) in rats. The objective of this study was to determine if recovery will eventually occur after ARF despite continued rapamycin treatment.",
"ARF was induced in rats by renal artery occlusion. Glomerular filtration rate... | Rapamycin delays but does not prevent renal recovery after ARF. MPT cells become resistant to rapamycin after prolonged exposure. We speculate that the ultimate recovery of renal function after ARF is due to the development of acquired tubular cell resistance to rapamycin. | no |
16,869,957 | Is porcine congenital splayleg characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression? | {
"contexts": [
"Porcine congenital splayleg (PCS) is the most important congenital condition of piglets, associated with lameness and immobility, of unknown aetiology and pathogenesis, hence the need to better understand the condition by defining, in the first instance, its histopathology and molecular pathology... | We demonstrated that PCS is a condition characterised by extensive fibre atrophy and raised fibre density, and propose that the combined differential expression of MAFbx and P311 is of potential in the diagnosis of subclinical PCS. | yes |
16,873,970 | Does motor enrichment sustain hindlimb movement recovered after spinal cord injury and glial transplantation? | {
"contexts": [
"This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge.",
"Motor activity was encouraged through provision of motor enrichment housing ... | Transection and transplantation of SC/OEG or OEG induced recovery of hindlimb function. This recovered hindlimb movement was sustained in rats housed in MEH but was progressively lost in rats housed in BH. Because benefits of MEH were not observed until 14 weeks after injury, long-term assessment of behavior is recomme... | yes |
16,849,387 | Is the mechanism of sevoflurane-induced cardioprotection independent of the applied ischaemic stimulus in rat trabeculae? | {
"contexts": [
"Sevoflurane protects the myocardium against ischaemic injury through protein kinase C (PKC) activation, mitochondrial K+ATP-channel (mitoK+ATP) opening and production of reactive oxygen species (ROS). However, it is unclear whether the type of ischaemia determines the involvement of these signall... | PKC, mitoK+ATP and ROS are involved in sevoflurane-induced cardioprotection after HYP or MI, suggesting that the means of mitochondrial ETC inhibition does not determine the signal transduction pathway for cardioprotection by anaesthetics. | yes |
16,857,393 | Does urinary pentosidine predict cartilage loss among subjects with symptomatic knee OA : the BOKS Study? | {
"contexts": [
"Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major changes in the extracellular matrix of cartilage is the age-related accumulation of advanced glycation end products (AGEs). Pentosidine, an AGE crosslink, is one of the fe... | Urinary pentosidine does not predict knee cartilage loss. Previous studies have suggested that local content within cartilage of AGEs is elevated in persons at high risk for progression. Our data suggest that these changes are not measurable systemically. Alternatively, urinary pentosidine levels reflect cartilage degr... | no |
16,865,644 | Does rescue therapy with tacrolimus and mycophenolate mofetil prevent deterioration of graft function in C4d-positive chronic allograft nephropathy? | {
"contexts": [
"Humoral alloresponses may contribute to chronic allograft nephropathy (CAN) in a subset of kidney transplant recipients. For chronic humoral rejection, the efficacy of rescue therapy with tacrolimus and mycophenolate mofetil has been suggested.",
"Eleven recipients with C4d-positive CAN (inde... | Our data argue against the efficacy of tacrolimus/mycophenolate mofetil rescue therapy in established C4d-positive chronic allograft dysfunction. Prospective trials are needed to evaluate whether early initiation of this or other antihumoral strategies are capable of effectively preventing alloantibody-mediated chronic... | no |
16,863,588 | Is tamoxifen effective in good prognosis patients with hepatocellular carcinoma? | {
"contexts": [
"Large randomised clinical trials and systematic reviews substantiate that tamoxifen is ineffective in improving survival of patients with hepatocellular carcinoma (HCC). However, a recent report suggested that the drug might prolong survival among patients with well preserved liver function. The ... | The recent suggestion that tamoxifen might be effective in the subgroup of patients with better prognosis is not supported by a reanalysis of the CLIP-1 trial. Tamoxifen should no longer be considered for the treatment of HCC patients and future trials of medical treatment should concentrate on different drugs. | no |
16,877,394 | Does desiccating stress stimulate expression of matrix metalloproteinases by the corneal epithelium? | {
"contexts": [
"To determine the effects of experimental dryness on production of matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) by the corneal epithelium.",
"Experimental dry eye (EDE) was created in two strains of mice: BALB/c and C57BL/6. Real-time PCR was performed with MMP a... | Corneal dryness stimulates production of certain MMPs in a strain-dependent fashion and causes the disruption of the corneal barrier, thus increasing permeability and corneal irregularity. | yes |
16,876,042 | Do antimicrobial endodontic compounds modulate alkylation-induced genotoxicity and oxidative stress in vitro? | {
"contexts": [
"To investigate if formocresol, paramonochlorophenol, or calcium hydroxide modulate the genotoxic effects induced by the oxidatively damaging agent hydrogen peroxide (H2O2) or the alkylating agent methyl methanesulfonate (MMS) in vitro by using single cell gel (comet) assay.",
"Chinese hamster... | Formocresol, paramonochlorophenol, and calcium hydroxide are not able to modulate alkylation-induced genotoxicity or oxidative DNA damage as depicted by the single cell gel (comet) assay. | no |
16,850,156 | Is fibrosis in non-cancerous tissue the unique prognostic factor for primary hepatocellular carcinoma without hepatitis B or C viral infection? | {
"contexts": [
"The relationship between the state of non-cancerous tissues in patients with hepatocellular carcinoma (HCC) who are negative for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), and hepatitis C antibody (HCVAb) (NBNC-HCC) and the prognosis has not yet been resolved.",
"... | Histological assessment of the degree of fibrosis in the non-cancerous regions of NBNC-HCC may be useful not only for the selection of the appropriate treatment but also for the prediction of postoperative prognosis. | yes |
16,850,155 | Do anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis? | {
"contexts": [
"High-mobility group box chromosomal protein 1 (HMGB1) has recently been shown to be an important late mediator of endotoxin shock, intraabdominal sepsis, and acute lung injury, and a promising therapeutic target of severe sepsis. We sought to investigate the effect of antibodies to HMGB1 on sever... | The present study demonstrates that anti-HMGB1 antibodies are effective in the treatment of severe sepsis in a rat model, thereby supporting the relevance of HMGB1 eradication therapy for severe sepsis. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.