pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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11,301,175 | Does non-pregnant circulatory volume status predict subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women? | {
"contexts": [
"Preeclampsia seems to be superimposed upon a preexisting hemodynamic, hemostatic, autoimmune or metabolic disorder. We tested the hypothesis that in normotensive thrombophilic formerly preeclamptic subjects, the non-pregnant circulatory volume status predicts the development of subsequent hyperte... | Pre-pregnant plasma volume in normotensive thrombophilic formerly preeclamptic women have predictive value with respect to hypertensive complications in the subsequent pregnancy. | yes |
11,286,323 | Does food influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder? | {
"contexts": [
"To determine whether food intake influences the pharmacokinetics of a new, once daily, extended release (ER) capsule formulation of tolterodine in healthy volunteers, and to compare its bioavailability with that of the existing immediate release (IR) tablet.",
"Open, randomised, 3-way crossov... | The new ER formulation of tolterodine shows no pharmacokinetic interaction with food. On the basis of these results, patients with overactive bladder may, therefore, be advised to take the drug without regard to the timing of meals, maximising convenience during therapy. | no |
11,308,999 | Are haemodynamic changes and vasopressin release consistently associated with carbon dioxide pneumoperitoneum in humans? | {
"contexts": [
"Conflicting haemodynamic changes, suggested to be caused by vasopressin release, have been reported during carbon dioxide (CO2) pneumoperitoneum. However, peritoneal stimulations including open surgery cause both a systemic vasopressor response and a vasopressin release, which are suppressed by o... | Continuous adequate depth of anaesthesia and normovolaemia may have prevented both a humoral and a haemodynamic response, initiated in the peritoneum by the contact with CO2 in previous investigations. | no |
11,287,832 | Do human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury? | {
"contexts": [
"Bleomycin (Bleo)-induced lung injury in mice serves as an animal model of pulmonary fibrosis. The pathogenesis of pulmonary fibrosis remains unclear, but it comprises both inflammatory and fibrotic components. The cytokine interferon (IFN)-alpha is produced by macrophages and may modulate both fi... | IFN-alpha may enhance Bleo-induced lung injury but this effect varies with different IFN preparations. | yes |
11,301,248 | Does notch signaling target the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila? | {
"contexts": [
"Members of the Notch family of receptors mediate a process known as lateral inhibition that plays a prominent role in the suppression of cell fates during development. This function is triggered by a ligand, Delta, and is implemented by the release of the intracellular domain of Notch from the me... | Our results show that, in Drosophila, an activity of Notch that is likely to be independent of Su(H) inhibits Wingless signaling on Ubx(VM)B. A possible target of this activity is dTcf. As dTcf has been shown to be capable of repressing Wingless targets, our results suggest that this repressive activity may be regulate... | yes |
11,301,249 | Does a novel pathway of cellular phosphatidylinositol ( 3,4,5 ) -trisphosphate synthesis is regulate by oxidative stress? | {
"contexts": [
"Phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] is a key second messenger found ubiquitously in higher eukaryotic cells. The activation of Class I phosphoinositide 3-kinases and the subsequent production of PtdIns(3,4,5)P(3) is an important cell signaling event that has been causally... | We describe for the first time a novel in vivo activity for Type Ialpha PIPkinase, and a novel pathway for the in vivo synthesis of functional PtdIns(3,4,5)P(3), a key lipid second messenger regulating a number of diverse cellular processes. | yes |
11,295,774 | Does nocturnal body core temperature fall in Parkinson 's disease but not in Multiple-System Atrophy? | {
"contexts": [
"To evaluate whether the circadian rhythm of body core temperature (CRT degrees ) can differentiate Multiple-System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).",
"We evaluated 14 patients with probable MSA, seven with IPD, and eight controls. After a preliminary evaluation of card... | The physiological nocturnal fall of BcT degrees is blunted in MSA patients mainly because BcT degrees did not decrease during sleep. This CRT degrees pattern is not justified by differences in sleep structure and may reflect an impairment of central sympathetic nervous system function. | yes |
11,287,254 | Are early puberty and early sexual activity associated with bulimic-type eating pathology in middle adolescence? | {
"contexts": [
"To examine the associations between early pubertal timing and early advanced sexual development with bulimic-type eating pathology in middle adolescents.",
"A total of 19,321 boys and 19,196 girls aged 14-16 years (mean age 15.3 years, standard deviation 0.59) responded to the School Health P... | To prevent bulimia nervosa and to create opportunities for early intervention, attention should be paid to early maturing girls and off-time maturing boys, as well as those with early onset of sexual activity. | yes |
21,876,966 | Are factors associated with medicine use and self medication different in adolescents? | {
"contexts": [
"To estimate the prevalence of medicine use among high school students (14-18 years old) living in an urban area in Southern Brazil and the proportion who self-medicate and to explore the association between medicine use and demographic, socioeconomic, and behavioral variables.",
"A school-bas... | The data from this study demonstrate a high prevalence of medicine use and self medication; however, the variables associated with medicine use and self medication differed. Urgent strategies to promote the rational use of drugs in this population and their families are necessary. | yes |
21,873,466 | Is viral clearance associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3? | {
"contexts": [
"Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy.",
"2255 treatment... | SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication. | yes |
21,878,132 | Are physicians a key to encouraging cessation of smoking among people living with HIV/AIDS : a cross-sectional study in the Kathmandu Valley , Nepal? | {
"contexts": [
"HIV care providers may be optimally positioned to promote smoking behaviour change in their patients, among whom smoking is both highly prevalent and uniquely harmful. Yet research on this front is scant, particularly in the developing country context. Hence, this study describes smoking behaviou... | Roughly one-third of HIV-positive smokers residing in the Kathmandu Valley, Nepal, are at the contemplation or preparation stage of smoking behaviour change, with rates significantly higher among those whose physicians have asked about their smoking status during any clinical interaction over the past year. Systematic ... | yes |
21,896,500 | Is albumin-induced apoptosis of glomerular parietal epithelial cells modulated by extracellular signal-regulated kinase 1/2? | {
"contexts": [
"The biological role(s) of glomerular parietal epithelial cells (PECs) is not fully understood in health or disease. Given its location, PECs are constantly exposed to low levels of filtered albumin, which is increased in nephrotic states. We tested the hypothesis that PECs internalize albumin and... | A normal role of PECs is to take up filtered albumin. However, this is increased in proteinuric glomerular diseases, leading to apoptosis through changes in ERK1/2. | yes |
21,872,559 | Is myocardial performance reduced immediately prior to ventricular ectopy? | {
"contexts": [
"We recently demonstrated local voltage potentials indicating conduction impairment and block in the sinus beats preceding ventricular premature beats (VPBs) originating in the ventricular outflow tracts.",
"The purpose of this study was to test the hypothesis that impairment of impulse conduc... | Ventricular ectopy is preceded by a significant decrease in myocardial performance in the last sinus beat preceding VPBs as observed in consecutive patients with a broad variety of heart conditions pointing to a mutual underlying electrical mechanism (ie, localized conduction block confined to an area surrounding the e... | yes |
21,894,807 | Does prophylactic intra-aortic balloon pump reduce C-reactive protein levels and early mortality in high-risk patients undergoing percutaneous coronary intervention? | {
"contexts": [
"Intra-aortic balloon pump (IABP) plays a pivotal role in the treatment of cardiogenic shock complicating acute myocardial infarction. However, the usefulness of prophylactic IABP support in high-risk patients during percutaneous coronary intervention (PCI) is still controversial, and its influenc... | The use of a prophylactic IABP in high-risk patients before PCI could reduce the CRP level and reduce mortality during the early phase following PCI. | yes |
21,873,469 | Does inhibition of histidine decarboxylase ablate the autocrine tumorigenic effects of histamine in human cholangiocarcinoma? | {
"contexts": [
"In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Cholangiocarcinoma is a biliary cancer with limited treatment options. Histamine interacts with four G... | The novel concept that an autocrine loop (consisting of enhanced histamine synthesis by HDC) sustains cholangiocarcinoma growth is proposed. Drug targeting of HDC may be important for treatment of patients with cholangiocarcinoma. | yes |
21,899,841 | Does proteomic analysis of intra-arterial thrombus secretions reveal a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm? | {
"contexts": [
"Abdominal aortic aneurysm (AAA) is usually accompanied by the formation of a large volume of intra-luminal thrombus (ILT). ILT-derived proteins have been suggested as circulating markers for AAA. We conducted a proteomic study screening whole and hexapeptide ligand library (HLL) treated ILT expla... | This proteomic analysis has identified a group of proteins concentrated in AAA ILT. Assessment of circulating concentrations of two representative polypeptides suggests for the first time that the ILT selectively sequesters proteins rather than actively releasing them. Further work is required to assess the mechanisms ... | yes |
21,898,712 | Is auditory novelty processing enhanced in obsessive-compulsive disorder? | {
"contexts": [
"Cognitive models propose that anxiety disorders are associated with an attentional bias toward potentially threatening stimuli. In this study, it was analyzed whether patients with obsessive-compulsive disorder (OCD) show enhanced responses of their event-related brain potentials to novel stimuli... | It is suggested that the novelty P3 amplitude increase in OCD patients represents a physiological indicator of an enhanced cortical orienting response implicating stronger involuntary shifts of attention. This characteristic is driven by novelty per se and not moderated by potential threat of upcoming events. | yes |
21,886,359 | Are sleep disturbances related to decreased transmission of blue light to the retina caused by lens yellowing? | {
"contexts": [
"Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the huma... | Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms. | yes |
21,873,257 | Does transcapsular arterial neovascularization after liver transplantation in pediatric patients indicate transplant failure? | {
"contexts": [
"To identify transcapsular arterial neovascularization with Doppler ultrasonography (US) in pediatric patients after liver transplantation and to assess the frequency of the finding, its underlying causes, and its relevance in terms of clinical outcome.",
"The study was approved by the local e... | Transcapsular arterial neovascularization, detected with color Doppler US, occurred in 9.5% (13 of 137) of pediatric patients and 8.4% (13 of 155) of liver transplants and was associated with underlying malperfusion and inflammation. The diagnosis of transcapsular arterial neovascularization was associated with reduced... | yes |
21,900,845 | Does strength training with blood flow restriction diminish myostatin gene expression? | {
"contexts": [
"The aim of the study was to determine whether the similar muscle strength and hypertrophy responses observed after either low-intensity resistance exercise associated with moderate blood flow restriction or high-intensity resistance exercise are associated with similar changes in messenger RNA (m... | We concluded that LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. | yes |
21,875,335 | Does treatment of metabolic syndrome slow progression of diabetic nephropathy? | {
"contexts": [
"Metabolic syndrome contributes to the development of albuminuria and to the decrease of glomerular filtration rate (GFR) in type 2 diabetes patients. The aim of this study was to analyze the effect of MS treatment on the progression of diabetic nephropathy (DN).",
"This was a retrospective an... | Metabolic syndrome treatment and control are independently associated with a lesser progression of DN. | yes |
21,875,336 | Is the waist circumference of risk in black South african men lower than in men of European ancestry? | {
"contexts": [
"Central obesity measured by waist circumference is a cardiovascular disease (CVD) risk factor; however, the waist circumference of risk in populations of African descent has not been identified. The International Diabetes Federation currently suggests that cutoffs established in men of European d... | For black South African diabetic men, CVD risk substantially increased with waist circumference >90 cm. The waist circumference cut point of >94 cm has the potential to misclassify many black South African diabetic men at risk for CVD. | yes |
21,886,847 | Are genetic variants in MARCO associated with the susceptibility to pulmonary tuberculosis in Chinese Han population? | {
"contexts": [
"Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in macrophage response to Mycoba... | Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis. | yes |
21,898,089 | Is human equilibrative nucleoside transporter 1 expression a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy? | {
"contexts": [
"We aimed to determine the relationship between the intratumoral expression of human equilibrative nucleoside transporter (hENT1), the main gemcitabine transporter into cells, and the outcome of gemcitabine-based chemoradiotherapy (Gem-CRT) in patients with International Union Against Cancer (UICC... | The hENT1 expression in pancreatic adenocarcinoma strongly influences the outcome of preoperative Gem-CRT treatment. This biomarker could become a useful predictor of therapeutic effect for gemcitabine-based therapy in pancreatic cancer patients. | yes |
21,897,744 | Does topical application of L-arginine block advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice? | {
"contexts": [
"Previous experiments from our laboratory showed that the oral intake of selected guanidino compounds could block the formation of crystallin-bound advanced ascorbylation products. Here we tested whether these were also active when applied as eye drops.",
"Two month old hSVCT2 transgenic mice ... | L-Arginine when applied both orally and topically is a potent and broad suppressor of advanced ascorbylation in the lens. Its uptake in rabbit lens upon topical application suggests transcorneal uptake into the human lens should be feasible for testing its potential anticataract properties in clinical trials. | yes |
21,873,111 | Does mobile phone emission modulate event-related desynchronization of α rhythms and cognitive-motor performance in healthy humans? | {
"contexts": [
"It has been shown that electromagnetic fields of Global System for Mobile Communications phone (GSM-EMFs) affect human brain rhythms (Vecchio et al., 2007, 2010), but it is not yet clear whether these effects are related to alterations of cognitive functions.",
"Eleven healthy adults underwen... | These results suggest that the peak amplitude of alpha ERD and the reaction time to the go stimuli are modulated by the effect of the GSM-EMFs on the cortical activity. | yes |
21,876,708 | Do hLA-B57 and gender influence the occurrence of tuberculosis in HIV infected people of south India? | {
"contexts": [
"Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on the role of host genetic factors in HIV-TB coinfection. Hence, a longitudinal study was undertaken to inve... | This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males. | yes |
21,885,869 | Does cCK stimulation of GLP-1 neurons involve α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs? | {
"contexts": [
"Glucagon-like peptide 1 (GLP-1) is involved in the central regulation of food intake. It is produced within the brain by preproglucagon (PPG) neurons, which are located primarily within the brain stem. These neurons project widely throughout the brain, including to the appetite centers in the hyp... | CCK activates NTS-PPG cells by a circuit involving adrenergic and glutamatergic neurons. NTS-PPG neurons integrate a variety of peripheral signals that indicate both long-term energy balance and short-term nutritional and digestional status to produce an output signal to feeding and autonomic circuits. | yes |
21,899,932 | Are increased Vitamin B12 levels associated with mortality in critically ill medical patients? | {
"contexts": [
"We describe an observational study in critically ill medical patients showing the association between serum Vitamin B12 levels measured on or near admission and the outcome in these patients.",
"We used the database of patients admitted to the Medical Intensive Care Unit (MICU) at the Hadassa... | Our data show that high serum Vitamin B12 levels are associated with increased mortality in critically ill medical patients. We suggest that Vitamin B12 levels should be included in the work-up of all medical intensive care patients, particularly those with a chronic health history and increased severity of illness. | yes |
21,892,859 | Does use of drospirenone/ethinyl estradiol ( DRSP/EE ) among women with acne reduce acne treatment-related resources? | {
"contexts": [
"Acne is a common dermatologic condition that extends into middle age, particularly among women, and is associated with substantial healthcare resource utilization. Drospirenone (DRSP), a synthetic progestin, has anti-androgenic activity, and women using DRSP 3.0 mg/ethinyl estradiol (EE) 0.02 mg ... | The study was retrospective in design and had a limited follow-up period. Database limitations restricted assessment of medication compliance and adherence. | yes |
21,883,439 | Does oral contraception enhance growth hormone responsiveness to hyper- and hypoglycaemia? | {
"contexts": [
"Plasma glucose levels influence growth hormone concentrations. Oral contraceptives are known to affect circulating growth hormone levels and glucose metabolism. While growth hormone plays an important role in hypoglycaemia counter-regulation, it has been shown that oral contraceptives increase gr... | Healthy women on oral contraceptive treatment display an increased responsiveness of growth hormone to hypoglycaemic, as well as hyperglycaemic conditions and generally higher serum growth hormone concentrations than women without oral contraceptives. Given the known boosting effects of growth hormone on hypoglycaemic ... | yes |
21,888,703 | Is socioeconomic status an independent predictor of biochemical recurrence among patients with prostate cancer who undergo radical prostatectomy? | {
"contexts": [
"Socioeconomic status (SES) may influence cancer characteristics and behavior in several aspects. We analyzed PCa characteristics and behavior among low income uninsured men, and compare them to high income patients with health insurance in a developing country.",
"A retrospective case-control... | Patients with low SES were older, presented more aggressive PCa characteristics and a high rate of disease recurrence. A low SES constituted an independent predictor for disease recurrence. | yes |
21,892,652 | Does bMP9 inhibit the proliferation and invasiveness of breast cancer cells MDA-MB-231? | {
"contexts": [
"Transforming growth factor-β (TGF-β) is known to promote tumor proliferation, migration, invasion, and metastasis. Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily. Several BMPs (BMP2 and BMP7) can enhance the invasion and bone metastasis of breast cancer cells. The functio... | Decreased BMP9 expression is associated with the elevated proliferation and migration of human breast cancer. BMP9 can inhibit the growth, invasion, and migration of breast cancer cells in vitro and in vivo. BMP9 is a putative tumor suppressor in breast cancer. | yes |
21,896,928 | Is mediobasal hypothalamic SIRT1 essential for resveratrol 's effects on insulin action in rats? | {
"contexts": [
"Sirtuin 1 (SIRT1) and its activator resveratrol are emerging as major regulators of metabolic processes. We investigate the site of resveratrol action on glucose metabolism and the contribution of SIRT1 to these effects. Because the arcuate nucleus in the mediobasal hypothalamus (MBH) plays a piv... | Taken together, these studies demonstrate that resveratrol improves glucose homeostasis mainly through a central SIRT1-dependent pathway and that the MBH is a major site of resveratrol action. | yes |
21,891,900 | Do in vivo bone response and interfacial properties of titanium-alloy implant with different designs in rabbit model with time? | {
"contexts": [
"Using implants for dental applications are well-accepted procedures as one of the solutions for periodontal defect repair. Suitable design and materials, their reaction with the surrounding hard tissues and interfacial biomechanical properties are still considered to be the primary criteria which... | From the physico-chemical and biomechanical observations, it was found that that smooth type implants were well accepted in the physiological condition although chances of elemental leaching from the surface were also observed. Increase of the surface roughness can help into the formation of physico-chemical bondage wi... | yes |
21,895,708 | Is alcohol dependence related to overall internalizing psychopathology load rather than to particular internalizing disorders : evidence from a national sample? | {
"contexts": [
"Alcohol dependence is more prevalent among those with any one of several anxiety or depressive (\"internalizing\") disorders than among those in the general population. However, because internalizing disorders are highly intercorrelated, it is ambiguous whether alcohol dependence is related to in... | The components of internalizing psychopathology that are associated with alcohol dependence are shared and cumulative among common anxiety and depressive disorders. These findings have the potential to influence clinical and scientific conceptualizations of the association between alcohol dependence and internalizing p... | yes |
21,890,425 | Does roux-en-Y gastric bypass improve hepatic mitochondrial function in obese rats? | {
"contexts": [
"Obesity-related fatty liver disease is linked to mitochondrial dysfunction and oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates mitochondrial function and is a transcriptor of multiple genes that produce antioxidants. Because Roux-en-Y gastric bypass (RYGB) improves ... | Diet-induced fatty liver is associated with mitochondrial dysfunction. RYGB increases COX-II, which is involved in mitochondrial respiration, and increases the nuclear translocation of the Nrf2 transcriptional factor, which is involved in mitochondrial biogenesis and function. Taken together, these data suggest that su... | yes |
21,876,086 | Are placental morphologic features and chorionic surface vasculature at term highly correlated with 3-dimensional sonographic measurements at 11 to 14 weeks? | {
"contexts": [
"The purpose of this study was to examine the potential for 3-dimensional sonographic measurement of the early placenta in predicting ultimate placental morphologic features at delivery.",
"In this prospective cohort study, we collected 3-dimensional sonographic volume sets of placentas at 11 ... | Many important ultimate placental morphologic features are likely predetermined early in pregnancy. Three-dimensional sonography may play an increasing role in the in utero evaluation of the early placenta. | yes |
21,880,279 | Does low-dose mifepristone increase uterine natural killer cell cytotoxicity and perforin expression during the receptive phase? | {
"contexts": [
"To investigate the immunologic mechanism by which low-dose mifepristone serves as an anti-implantation contraceptive drug.",
"In vitro study.",
"University hospital and research laboratory.",
"Fifteen normally cycling patients at the \"window of implantation.\"",
"A human endometr... | Mifepristone may negatively regulate implantation by increasing the cytotoxicity of uNK cells, and this increased cytotoxicity may result from increased PFN expression. These findings provide further evidence to support the potential contraceptive activity of low-dose mifepristone. | yes |
21,896,859 | Does topical dexamethasone-cyclodextrin microparticle eye drop for diabetic macular edema? | {
"contexts": [
"To test the safety and efficacy of topical 1.5% dexamethasone aqueous eye drops with cyclodextrin microparticles for diabetic macular edema (DME).",
"Nineteen eyes of 19 consecutive patients with DME were administered dexamethasone-cyclodextrin eye drops three or six times a day for 4 weeks a... | Based on this short pilot study, topical dexamethasone-cyclodextrin eye drops are well tolerated, decrease central macular thickness, and improve visual acuity in DME. The results encourage comparative studies between dexamethasone cyclodextrin microparticle eye drops and other treatments for DME. (http://www.umin.ac.j... | yes |
21,896,855 | Is the clinical phenotype of trachomatous trichiasis in Ethiopia : not all trichiasis due to entropion? | {
"contexts": [
"Trachomatous trichiasis (TT) is usually described as a cicatricial entropion of the upper lid; however, other forms of trichiasis have been reported. This variation in clinical phenotype is potentially important for treatment guidelines. Therefore, this study was conducted to investigate the rang... | Many patients with TT have minimal or no entropion. The trichiasis is frequently attributable to metaplastic or misdirected eyelashes. The results of tarsal rotation surgery in TT patients without manifest entropion should be investigated and potentially alternative treatment strategies evaluated. | yes |
21,885,500 | Do levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis? | {
"contexts": [
"Serum matrix metalloproteinase-3 (MMP-3) has been shown to reflect disease activity in ankylosing spondylitis (AS) and rheumatoid arthritis. Elevated levels have been found in juvenile idiopathic arthritis (JIA). In the enthesitis-related arthritis category of JIA (JIA-ERA), we studied whether se... | MMP-3 levels are a good marker for disease activity in JIA-ERA. | yes |
21,890,386 | Is carotid endarterectomy within seven days after the neurological index event safe and effective in stroke prevention? | {
"contexts": [
"Timing of surgery remains a controversial subject with some concerns persisting that the benefit of early carotid endarterectomy (CEA) offsets the perioperative risks. We investigated the neurological outcome of patients with symptomatic internal carotid artery (ICA) stenosis after surgery in rel... | An infarction on the preoperative CCT leads to an increased risk for a postoperative deterioration after CEA. Patients should be treated at an early point in time with bland CCTs. | yes |
21,883,198 | Is aspirin first-line treatment for migraine and episodic tension-type headache regardless of headache intensity? | {
"contexts": [
"(1) To establish whether pre-treatment headache intensity in migraine or episodic tension-type headache (ETTH) predicts success or failure of treatment with aspirin; and (2) to reflect, accordingly, on the place of aspirin in the management of these disorders.",
"Stepped care in migraine mana... | In neither migraine nor ETTH does pre-treatment headache intensity predict success or failure of aspirin. This is not an arguable basis for stratified care in migraine. In both disorders, aspirin is first-line treatment regardless of headache intensity. | yes |
21,871,617 | Does the association between anomalous self-experience and suicidality in first-episode schizophrenia seem mediated by depression? | {
"contexts": [
"A recent hypothesis is that suicidality in schizophrenia may be linked to the patients' altered basic self-awareness or sense of self, termed self-disorders (SDs).",
"The aim of the study was to investigate whether SDs in first-episode schizophrenia spectrum disorders are related to suicidali... | The interaction between anomalous self-experiences and depression could be a rational clinical target for the prevention of suicidality in the early phases of schizophrenia and supports the rationale for including assessment of SDs in early intervention efforts. | yes |
21,881,247 | Does prevalence and correlate of physiological valvular regurgitation in healthy subjects? | {
"contexts": [
"Although echo Doppler machines have consistently advanced within a quarter of a century, age related prevalence of valvular regurgitation detected by currently available echo machines remains uncertain. The aim of this study was to investigate the prevalence and correlates of valvular regurgitati... | In healthy subjects, AR, MR or TR are commonly detected by using a current echo machine. These "physiological" valvular regurgitations should not be considered as a "pathological" valvular heart disease. | yes |
21,901,393 | Does t-cell compartment in synovial fluid of pediatric patients with JIA correlate with disease phenotype? | {
"contexts": [
"Juvenile idiopathic arthritis (JIA) is an autoimmune disease where T cells are key players. It can be classified into two main clinical diseases: polyarticular and pauciarticular, based on the number of joints involved. Oligoarthritis, which is considered a pauciarticular subtype since it involve... | In pediatric JIA patients, we showed an alteration in the T cells from synovial fluid, which correlated with disease phenotype, assumedly secondary to enhanced proliferation, clonal TCR restriction, and reduced T-cell production, possibly reflecting a different disease or a different course of disease progression. | yes |
21,898,507 | Does persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affect liver fibrosis and differentiation? | {
"contexts": [
"Alteration of cell surface proteolysis has been proposed to play a role in liver fibrosis, a grave complication of biliary atresia (BA). In this study we investigated the roles of hepatocyte growth factor activator inhibitor (HAI)-1 and -2 in the progression of BA. The expression levels of HAI-1 ... | HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation; they could be investigated as disease markers and potential therapeutic targets. | yes |
21,898,504 | Are comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C : new algorithms more precise and entirely noninvasive? | {
"contexts": [
"The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm (BA), which cross-check FibroTest with the aspartate aminotransferase-to-platelet ratio index (APRI) or FibroScan, are very accurate but provide only a binary diagnosis of significant fibrosis (SAFE or BA for Metav... | SAFE and BA for significant fibrosis or cirrhosis are very accurate. However, their successive use induces a significant decrease in diagnostic accuracy and a significant increase in required liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests was as accurate as successive SAFE or... | yes |
21,889,309 | Is accuracy of self-reported family history strongly influenced by the accuracy of self-reported personal health status of relatives? | {
"contexts": [
"We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards: family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives.",
"Subjects were participant... | The accuracy of self-reported family history of diabetes and hypertension is strongly influenced by the accuracy of self-reported personal health status of relatives. Raising awareness of personal health status is crucial to ensure the utility of family history for the assessment of risk and disease prevention. | yes |
21,887,232 | Does fAK regulate intestinal epithelial cell survival and proliferation during mucosal wound healing? | {
"contexts": [
"Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for epithelial homeostasis and restitution, includin... | In the colon, FAK functions as a regulator of epithelial cell survival and proliferation under conditions of mucosal injury and a mechanosensor of tissue compliance, inducing repair-driven proliferation in the colonic epithelium through upregulation of cyclin D1. | yes |
21,871,763 | Does sublingual tissue perfusion improve during emergency treatment of acute decompensated heart failure? | {
"contexts": [
"The aim of this study was to measure sublingual perfused capillary density (PCD) to assess sublingual microvascular perfusion during emergency department (ED) treatment of acute decompensated heart failure (ADHF).",
"This prospective, observational study enrolled ED patients with ADHF, measur... | Sublingual tissue perfusion is diminished in ADHF but increases with treatment. It may represent a quantitative way to evaluate ADHF in the ED setting. | yes |
21,887,602 | Do sevoflurane and desflurane protect cholinergic-induced bronchoconstriction of hyperreactive airways in rabbits? | {
"contexts": [
"The potential of desflurane to alter respiratory mechanics in the presence of bronchial hyperresponsiveness (BHR) is still a subject of debate. Accordingly, we evaluated the bronchoprotective potential of desflurane compared with sevoflurane following cholinergic lung constriction in rabbits with... | If the contractile stimulus is cholinergic in origin, sevoflurane and desflurane exert similar bronchoprotective potentials to act against lung constriction independent of the presence of BHR. These volatile anesthetics otherwise lack a potential to improve the enhanced ventilation heterogeneities that develop particul... | yes |
21,887,608 | Does detection of asymptomatic adenocarcinoma at endoscopy prior to gastric banding justify routine endoscopy? | {
"contexts": [
"Pre-operative upper gastrointestinal (GI) endoscopy prior to gastric banding surgery remains controversial. We report the finding of asymptomatic oesophageal adenocarcinomas detected at pre-operative endoscopy in our unit.",
"Data from a prospectively maintained database concerning the period... | The detection of two early, asymptomatic oesophageal adenocarcinomas in a high risk patient group justifies our policy of routine upper GI endoscopy prior to gastric banding surgery. | yes |
21,880,129 | Does a novel reporter of notch signalling indicate regulated and random Notch activation during vertebrate neurogenesis? | {
"contexts": [
"Building the complex vertebrate nervous system involves the regulated production of neurons and glia while maintaining a progenitor cell population. Neurogenesis starts asynchronously in different regions of the embryo and occurs over a long period of time, allowing progenitor cells to be exposed... | A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity on a cell-by-cell basis, as neural progenitors progress through the cell cycle in the chick neural tube. Notch activity patterns in this cell population provide evidence for distinct Notch signalling ... | yes |
21,881,505 | Do an update on influenza vaccination in patients with egg allergy? | {
"contexts": [
"Egg allergy is a common problem affecting young children especially. There has been much debate over the past several decades on how to approach the subject of influenza vaccination in children with egg allergy.",
"Because of concern regarding the egg protein content in the influenza virus va... | In considering vaccination in a patient with a history of egg allergy, several factors should be weighed, including the severity of the egg allergy, the egg content of vaccines, and the setting of vaccine administration. However, it appears that the risk of anaphylaxis to the influenza vaccine in patients with egg alle... | yes |
21,898,432 | Does injection of human mesenchymal stem cells improve healing of vocal folds after scar excision -- a xenograft analysis? | {
"contexts": [
"Using a xenograft model the aim was to analyze if injection of human mesenchymal stem cells (hMSC) into the rabbit vocal fold (VF), after excision of an established scar, can improve the functional healing of the VF.",
"Prospective design with an experimental xenograft model.",
"The VFs o... | Human mesenchymal stem cells injected into the rabbit VF following the excision of a chronic scar, were found to enhance the functional healing of the VF with reduced lamina propria thickness and restored viscoelastic shear properties. | yes |
21,890,222 | Does survey disability questionnaire generate valid accurate data compared to clinical assessment on an older population? | {
"contexts": [
"Policy-makers and health care managers need accurate information on disabilities in the population to plan appropriate services to the older population. Disability information from population surveys are often very crude as compared to information used on the clinical field. This study aimed to v... | A survey questionnaire is not a valid method for accurately estimating disability in a population. | no |
21,900,460 | Is the shortest way to reach nutritional goals to adopt Mediterranean food choices : evidence from computer-generated personalized diets? | {
"contexts": [
"Dietary guidelines can be derived from dietary patterns known to be healthy such as the traditional Mediterranean diet. They can also be deduced by translating a set of nutrient recommendations into food combinations. However, the latter may vary depending on the decisions made by different exper... | Whether recommendations on total fats, MUFAs, or total carbohydrates are included or not in the definition of overall nutrient adequacy, foods typical of the Mediterranean diet are needed to reach overall nutrient adequacy. | yes |
21,878,850 | Does one-year choroidal thickness result after photodynamic therapy for central serous chorioretinopathy? | {
"contexts": [
"To retrospectively evaluate choroidal thickness 1 year after photodynamic therapy in eyes with central serous chorioretinopathy using optical coherence tomography.",
"Central serous chorioretinopathy was diagnosed using fluorescein angiography, and indocyanine green angiography was used to ev... | Half-dose photodynamic therapy for central serous chorioretinopathy resulted in thinner subfoveal choroidal thickness 1 month after treatment, decreased the choroidal vascular hyperpermeability, and maintained the remission for 1 year. Enhanced depth imaging optical coherence tomography was helpful for monitoring the p... | yes |
21,890,538 | Are plasma concentrations of efavirenz associated with body weight in HIV-positive individuals? | {
"contexts": [
"Efavirenz is among the most widely used antiretroviral drugs. Increased efavirenz exposure has been associated with CNS side effects and also with the chance of emergence of resistance upon treatment interruptions. The objective of this study was to evaluate factors associated with efavirenz plas... | In this cohort of well-controlled HIV-positive individuals, patients with lower weight or body mass index had a higher chance of presenting elevated plasma concentrations of efavirenz. Therapeutic drug monitoring to adjust dose might be a helpful tool to decrease efavirenz dose in order to minimize costs and adverse ef... | yes |
21,890,535 | Do plasma calprotectin levels reflect disease severity in patients with chronic heart failure? | {
"contexts": [
"Low-grade inflammation has been associated with cardiovascular disease (CVD) and chronic heart failure (CHF). The aim of the present study was to investigate the potential usefulness of the inflammatory protein calprotectin as a biomarker in CHF.",
"Plasma calprotectin was measured in 193 CHF... | Plasma calprotectin is increased in CHF patients, indicating that inflammatory activity is upregulated in CHF and may be associated with the severity of CHF. | yes |
21,889,082 | Does extraction of maxillary first molars improve second and third molar inclinations in Class II Division 1 malocclusion? | {
"contexts": [
"The aim of this study was to assess the changes in inclination of the maxillary second (M2) and third (M3) molars after orthodontic treatment of Class II Division 1 malocclusion with extraction of maxillary first molars.",
"Two groups of subjects were studied. The experimental group consisted... | Extraction of the maxillary first molars in Class II Division 1 patients results in significant uprighting of M2 and M3 and facilitates the normal eruption of M3. | yes |
21,890,304 | Does pioglitazone prevent intimal hyperplasia in experimental rabbit vein grafts? | {
"contexts": [
"Intimal hyperplasia is a major obstacle to patency after vein grafting. Several clinical trials revealed that pioglitazone, a peroxisome proliferator-activated receptor-γ ligand, exerts beneficial actions on cardiovascular complications. We investigated whether pioglitazone modulates intimal hype... | Pioglitazone attenuates intimal hyperplasia of the vein graft after autologous bypass grafting by its ability to suppress cell proliferation and enhance apoptosis. Pioglitazone could represent a therapeutic target for the prevention of graft failure after bypass grafting. | yes |
21,885,853 | Does microRNA-758 regulate cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1? | {
"contexts": [
"The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular cholesterol accumulation; however, the mechanism involved in posttranscriptional regulation of ABCA1 is poorly understood. We previously showed that m... | We identified miR-758 as a novel miRNA that posttranscriptionally controls ABCA1 levels in different cells and regulates macrophage cellular cholesterol efflux to apoA1, opening new avenues to increase apoA1 and raise high-density lipoprotein levels. | yes |
21,885,850 | Does angiopoietin-1 require IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense? | {
"contexts": [
"IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding the Rho GTPase Rac1 to maintain its activity. The functions of IQGAP1 in endothelial cells beyond angiogenesis remain unclear. We hypothes... | These experiments are the first demonstration of IQGAP1 regulating barrier function in any cell type. Further, our data show that Angpt-1 requires IQGAP1 as an indispensable activator of Rac1. | yes |
21,875,437 | Does enchanced levels of apolipoprotein M during HBV infection feedback suppress HBV replication? | {
"contexts": [
"Chronic liver diseases can interfere with hepatic metabolism of lipoproteins, apolipoproteins. Hepatitis B virus (HBV) is a major etiological agent causing acute and chronic liver diseases. Apolipoprotein M (ApoM) is a high-density lipoprotein (HDL) apolipoprotein and exclusively expressed in the... | Raised ApoM levels in HBV infection may in turn suppress HBV replication, one of the protective mechanisms of nature. | yes |
21,893,328 | Does the angiogenic factor Del1 prevent apoptosis of endothelial cells through integrin binding? | {
"contexts": [
"Del1 is a secreted protein that is expressed in the endothelium during development and can stimulate angiogenesis through integrin binding and signaling. We were interested in the specific effects of del1 on endothelial cell biology to gain insight into its biologic role during angiogenesis.",
... | Del1 has been previously shown to promote vascular smooth muscle cell adhesion, migration, and proliferation. We demonstrate here that Del1 prevented apoptosis of endothelial cells in cell culture through integrin binding without any effect on proliferation. | yes |
21,883,784 | Do homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma? | {
"contexts": [
"Recent reports suggest genetic polymorphisms influence susceptibility to rituximab-induced late-onset neutropenia (LON), which in turn may be a predictor of good outcome in B-cell lymphoma.",
"We report the largest study to date assessing FCGR3A-V158F polymorphisms in diffuse large B-cell lym... | Polymorphic analysis may be a predictive tool to identify those at high risk of LON. Prospective studies are required to establish definitively if LON or FCGR3A-158V/V genotype influences outcome. | yes |
21,880,996 | Do anatomy and physiology predict response to motor cortex stimulation after stroke? | {
"contexts": [
"Preclinical studies found that epidural motor cortex stimulation improved motor deficits after stroke, but a phase III trial in humans did not corroborate these results. The current retrospective analysis examined subjects randomized to stimulation in order to identify features distinguishing res... | In this clinical stroke trial, the more that the physiologic integrity of the motor system was preserved, the more likely that a patient was to derive gains from subsequent therapy, consistent with preclinical models. Functional and structural preservation of key brain substrates are important to deriving gain from a r... | yes |
21,875,860 | Is biventricular pacing superior to right ventricular pacing in bradycardia patients with preserved systolic function : 2-year results of the PACE trial? | {
"contexts": [
"The Pacing to Avoid Cardiac Enlargement (PACE) trial is a prospective, double-blinded, randomized, multicentre study that reported the superiority of biventricular (BiV) pacing to right ventricular apical (RVA) pacing in the prevention of left ventricular (LV) adverse remodelling and deterioratio... | Left ventricular adverse remodelling and deterioration of systolic function continues at the second year after RVA pacing. This deterioration is prevented by BiV pacing. | yes |
21,899,534 | Is positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis widespread after status epilepticus? | {
"contexts": [
"γ-Aminobutyric acid (GABA)ergic transmission plays an important role in the initiation of epileptic activity and the generation of ictal discharges. The functional alterations in the epileptiform hippocampus critically depend on GABAergic mechanisms and cation-chloride cotransporters.",
"To u... | Our results suggest that alterations of cation-chloride cotransporter functions, comprising a higher NKCC1 action, contribute to hyperexcitability within the hippocampus following SE. | yes |
21,888,677 | Does esmolol modulate inhibitory neurotransmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat? | {
"contexts": [
"β1-adrenaline receptor antagonists are often used to avoid circulatory complications during anesthesia in patients with cardiovascular diseases. Of these drugs, esmolol, a short-acting β antagonist, is also reported to exert antinociceptive and anesthetic sparing effects. This study was designed ... | These data suggest that esmolol modulates inhibitory transmitter release in the Sp5c through a mechanism involving Ca2+-entry but in a β1-adrenoceptor-independent manner. The present results suggest that the facilitation of inhibitory transmitter release in the central nociceptive network underlies, at least in part, t... | yes |
21,894,795 | Are qRS duration and QTc interval predictors of risk for ventricular arrhythmias during cardiac resynchronization therapy? | {
"contexts": [
"QRS duration (QRSd) and prolonged corrected QT interval (QTc) are associated with ventricular arrhythmic events. This study was designed to determine whether CRT by means of biventricular pacing alters the QTc and QRSd, and whether such changes are related to the risk of sustained ventricular tac... | A pacing-induced increase in QTc and QRSd is related to sVTA in patients with CRT. Further studies are needed to determine whether optimization of CRT with the goal to achieve a narrow paced QRSd can reduce the occurrence of sVTA. | yes |
21,896,930 | Does deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice? | {
"contexts": [
"Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression might t... | These results demonstrate that G6pc2 is an important driver for the selection and expansion of islet-reactive CD8(+) T cells infiltrating NOD/ShiLtJ islets. However, autoreactivity to G6pc2 is not essential for the emergence of autoimmune diabetes. The results remain consistent with previous studies indicating that ins... | no |
21,896,931 | Do angiotensin II receptors modulate muscle microvascular and metabolic responses to insulin in vivo? | {
"contexts": [
"Angiotensin (ANG) II interacts with insulin-signaling pathways to regulate insulin sensitivity. The type 1 (AT(1)R) and type 2 (AT(2)R) receptors reciprocally regulate basal perfusion of muscle microvasculature. Unopposed AT(2)R activity increases muscle microvascular blood volume (MBV) and gluco... | We conclude that both AT(1)Rs and AT(2)Rs regulate insulin's microvascular and metabolic action in muscle. Although AT(1)R activity restrains muscle metabolic responses to insulin via decreased microvascular recruitment and insulin delivery, AT(2)R activity is required for normal microvascular responses to insulin. Thu... | yes |
21,896,932 | Are expansion of Th17 cells and functional defects in T regulatory cells key features of the pancreatic lymph nodes in patients with type 1 diabetes? | {
"contexts": [
"Autoimmune diseases, including type 1 diabetes, are thought to have a Th17-cell bias and/or a T-regulatory cell (Treg) defect. Understanding whether this is a hallmark of patients with type 1 diabetes is a crucial question that is still unsolved, largely due to the difficulties of accessing tissu... | These data provide evidence for an unbalanced immune status in the PLNs of type 1 diabetic subjects, and treatments restoring the immune homeostasis in the target organ of these patients represent a potential therapeutic strategy. | yes |
21,888,020 | Do lipid peroxidation and parathyroid hormone influence the cytosolic calcium levels of erythrocytes in peritoneal dialysis patients? | {
"contexts": [
"The aim of this study was to examine the alterations in calcium and lipid peroxidation in red blood cells (RBCs) and serum samples of continuous ambulatory peritoneal dialysis (CAPD) patients. We also investigated the relationship between parathyroid hormone (PTH) and calcium homeostasis in this ... | Our results confirm that oxidative stress is an important risk factor for CAPD. The results of multiple regression analysis suggest that RBC calcium was affected by both increased levels of TBARS and PTH. | yes |
21,880,231 | Does hypoglycemia impair quality of blood glucose simulation in a clinical decision support system? | {
"contexts": [
"Clinical decision support systems allow for decisions based on blood glucose simulations. The DiasNet simulation tool is based on accepted principles of physiology and simulates blood glucose concentrations accurately in type 1 diabetes mellitus (T1DM) patients during periods without hypoglycemia... | The present data show that hypoglycemia introduces substantial and systematic simulation errors for up to 24 h after hypoglycemia. This underlines the need for further evaluation of mechanisms behind this putative long-term glucose counter-regulation to hypoglycemia. When using blood glucose simulations in decision sup... | yes |
21,886,796 | Does high density lipoprotein ( HDL ) promote glucose uptake in adipocytes and glycogen synthesis in muscle cells? | {
"contexts": [
"High density lipoprotein (HDL) was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells.",
"Actions o... | HDL stimulates glucose uptake in 3T3-L1 adipocytes through enhancing GLUT4 translocation by mechanisms involving PI3K/Akt via SR-BI and AMPK signaling pathways, and increases glycogen deposition in L6 muscle cells through promoting GSK3 phosphorylation. | yes |
21,876,507 | Is glucocorticoid receptor polymorphism associated with lithium response in bipolar patients? | {
"contexts": [
"Glucocorticoid receptor has been considered in the pathogenesis of bipolar disorder as it is an important regulator of the circadian rhythm and HPA negative feedback. As glucocorticoid receptor may be possibly related to lithium action we aimed to investigate variation in the GR gene in associati... | The GR gene variation seems to be involved in the response to lithium treatment in our group of bipolar patients. | yes |
21,895,733 | Are chemerin levels positively correlated with abdominal visceral fat accumulation? | {
"contexts": [
"Chemerin, a recently discovered adipocytokine, may be linked to obesity and obesity-associated metabolic complications. However, the relationship between visceral fat accumulation and chemerin is still unknown. Therefore, we investigated the relationship between serum chemerin levels and body com... | Abdominal visceral fat accumulation, blood pressure and lipid profile were significantly associated with serum chemerin levels. Our findings suggest that chemerin may be a mediator that links visceral obesity to cardiovascular risk factors. | yes |
21,894,061 | Does abnormal T2-weighted MRI signal surrounding lead in a subset of deep brain stimulation patients? | {
"contexts": [
"Deep brain stimulation (DBS) surgery is a common treatment option for numerous neurological disorders. However, it is not without potential complications, such as hemorrhage and infection. Interestingly, we have observed several instances of abnormal T2-weighted signal hyperintensity surrounding ... | Fifteen instances of T2 signal hyperintensity surrounding DBS leads on postoperative MRI scans were observed across 239 implants (6.3% incidence) in 133 patients. The signal characteristics were most consistent with vasogenic edema, possibly representing an inflammatory response. The finding was typically unilateral, e... | yes |
21,883,739 | Is liver stiffness measured by transient elastography a predictor of hepatocellular carcinoma development in viral hepatitis? | {
"contexts": [
" To investigate the value of liver stiffness in diagnosing hepatocellular carcinoma (HCC) among patients with viral hepatitis, and to prospectively investigate relationships between liver stiffness and HCC development.",
" Liver stiffness was measured by transient elastography for 157 patie... | Liver stiffness as measured by transient elastography is a predictor of HCC development in viral hepatitis. | yes |
21,896,198 | Does acute inhalation of hypertonic saline improve mucociliary clearance in all children with cystic fibrosis? | {
"contexts": [
"Little is known of how mucociliary clearance (MCC) in children with cystic fibrosis (CF) and normal pulmonary function compares with healthy adults, or how an acute inhalation of 7% hypertonic saline (HS) aerosol affects MCC in these same children.",
"We compared MCC in 12 children with CF an... | These data suggest that percent MCC varies significantly between children with CF lung disease and normal pulmonary functions, with some children demonstrating MCC values within the normal range and others showing MCC values that are below normal values. In addition, although MCC did not improve in all children after i... | no |
21,896,199 | Does methyl-binding domain protein-based DNA isolation from human blood serum combine DNA analyses and serum-autoantibody testing? | {
"contexts": [
"Circulating cell free DNA in serum as well as serum-autoantibodies and the serum proteome have great potential to contribute to early cancer diagnostics via non invasive blood tests. However, most DNA preparation protocols destroy the protein fraction and therefore do not allow subsequent protein... | MBD affinity purification allows DNA isolations under native conditions retaining the protein function, thus for example enabling combined analyses of DNA methylation and autoantigene-profiles from the same serum sample and thereby improving minimal invasive diagnostics. | yes |
21,896,197 | Does a unique protein profile of peripheral neutrophils from COPD patients reflect cytokine-induced protein profiles of neutrophils in vitro? | {
"contexts": [
"Inflammation, both local and systemic, is a hallmark of chronic obstructive pulmonary disease (COPD). Inflammatory mediators such as TNFα and GM-CSF are secreted by lung epithelium, alveolar macrophages and other inflammatory cells and are thought to be important contributors in the pathogenesis ... | These results show that neutrophils from COPD patients have a unique protein profile compared to neutrophils from healthy age-matched controls. Furthermore, the neutrophil profiles of COPD patients do not reflect putative dominant signals induced by TNFα, GM-CSF or their combination. Our results indicate that systemic ... | no |
21,896,194 | Do perspectives on child diarrhoea management and health service use among ethnic minority caregivers in Vietnam? | {
"contexts": [
"In Vietnam, primary government health services are now accessible for the whole population including ethnic minority groups (EMGs) living in rural and mountainous areas. However, little is known about EMGs' own perspectives on illness treatment and use of health services. This study investigates ... | In order to improve EMGs' use of government health services it is necessary to improve the communication skills of health staff and to acknowledge both EMGs' explanatory disease models and the significant socio-economic constraints they experience. Broader health promotion programs should address the significant gender... | yes |
21,898,359 | Is cyclin-dependent kinase inhibitor p21 , via its C-terminal domain , essential for resolution of murine inflammatory arthritis? | {
"contexts": [
"The mechanism responsible for persistent synovial inflammation in rheumatoid arthritis (RA) is unknown. Previously, we demonstrated that expression of the cyclin-dependent kinase inhibitor p21 is reduced in synovial tissue from RA patients compared to osteoarthritis patients and that p21 is a nov... | These are the first reported data to reveal that p21 has a key role in limiting the activation response of macrophages in an inflammatory disease such as RA. Thus, targeting p21 in macrophages may be crucial for suppressing the development and persistence of RA. | yes |
21,894,158 | Is metabolic syndrome associated with increased risk of recurrent colorectal adenomas in Korean men? | {
"contexts": [
"Because of the high incidence of recurrent colorectal adenomas, regular surveillance by colonoscopy is recommended. However, there is still a shortage of information on the factors that influence the incidence of recurrent colorectal adenomas in patients with a history of these lesions. The aim o... | Metabolic syndrome and obesity were significantly associated with the development of recurrent colorectal adenomas in Korean adult males. Furthermore, these associations were more strongly associated with advanced adenomas. | yes |
21,873,313 | Is there no association of CCR6 polymorphisms with susceptibility to Behcet 's disease in two Chinese Han populations? | {
"contexts": [
"Polymorphisms of CC chemokine receptor 6 (CCR6) genes have recently been reported to be associated with the susceptibility to several immune-related diseases. This study was conducted to examine the association of CCR6 with Behçet's disease (BD) in two Chinese Han populations.",
"A total of 4... | The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations. | yes |
21,873,312 | Does c5a contribute to intraocular inflammation by affecting retinal pigment epithelial cells and immune cells? | {
"contexts": [
"The complement activation molecule C5a has been found in the eye and is implicated in the pathogenesis of ocular inflammatory diseases. In this study, the authors sought to investigate C5a's effects on human retinal pigment epithelial (RPE) cells and peripheral blood mononuclear cells (PBMCs), an... | The results provide a direct link between complement activation and intraocular inflammation. This line of information may help to understand the mechanism of the pathogenesis of intraocular inflammatory diseases. Moreover, the authors show that a close, reciprocal interaction between the innate immune system and the a... | yes |
21,898,499 | Does recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibit hepatocellular carcinoma xenograft growth in mice? | {
"contexts": [
"Hepatocyte nuclear factor-1alpha (HNF1α) is one of the key transcription factors of the HNF family, which plays a critical role in hepatocyte differentiation. Substantial evidence has suggested that down-regulation of HNF1α may contribute to the development of hepatocellular carcinoma (HCC). Here... | These results suggest that the potent inhibitive effect of HNF1α on HCC is attained by inducing the differentiation of hepatoma cells into mature hepatocytes and G(2)/M arrest. HNF1α might represent a novel, promising therapeutic agent for human HCC treatment. Our findings also encourage the evaluation of differentiati... | yes |
21,899,715 | Does patterns and correlate of prescription opioid use in OEF/OIF veterans with chronic noncancer pain? | {
"contexts": [
"Little is known about the treatment Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans receive for chronic noncancer pain (CNCP). We sought to describe the prevalence of prescription opioid use, types, and doses of opioids received and to identify correlates of receiving prescr... | Prescription opioid use is common among OEF/OIF veterans with CNCP and is associated with several pain diagnoses and medical conditions. | yes |
21,878,847 | Does topical aqueous suppression significantly affect duration of intraocular gas tamponade after vitrectomy? | {
"contexts": [
"To determine if topical aqueous suppression affects the duration of intraocular sulfur hexafluoride (SF6) gas tamponade after pars plana vitrectomy.",
"A prospective randomized controlled trial was conducted on patients undergoing 23-gauge sutured pars plana vitrectomy with air-fluid exchange... | Topical aqueous suppression with dorzolamide-timolol does not have a large effect on duration of SF6 gas tamponade after pars plana vitrectomy. | no |
21,875,175 | Is mindfulness associated with fewer PTSD symptoms , depressive symptoms , physical symptoms , and alcohol problems in urban firefighters? | {
"contexts": [
"This study investigated the association between mindfulness, other resilience resources, and several measures of health in 124 urban firefighters.",
"Participants completed health measures of posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, physical symptoms, and alcohol pr... | Mindfulness may be important to consider and include in models of stress, coping, and resilience in firefighters. Future studies should examine the prospective relationship between mindfulness and health in firefighters and others in high-stress occupations. | yes |
21,889,310 | Do multivariate graphical methods provide an insightful way to formulate explanatory hypotheses from limited categorical data? | {
"contexts": [
"Graphical methods for generating explanatory hypotheses from limited categorical data are described and illustrated.",
"Univariate, bivariate, multivariate, and multiplicative graphical methods were applied to clinical data regarding very ill older persons. The data to which these methods wer... | Illustrative applications of a sequence of graphical procedures yield more informative and less abstract representations of limited data than do descriptive statistics alone, and by doing so, they aid in the formulation of explanatory hypotheses. | yes |
21,889,313 | Is chlamydia pneumoniae heat shock protein 60 associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients? | {
"contexts": [
"Chlamydia pneumoniae heat shock protein (HSP) 60 is known to contribute to the activation of inflammation. In addition, there are contradictory reports on C. pneumoniae and their role in activation of pathways (apoptotic/antiapoptotic/necrosis) in coronary artery disease (CAD). Hence, more studie... | Genes/proteins of pre-apoptotic caspase dependent/independent pathways, chemokines, and inflammatory cytokines receptors were significantly up-regulated in human atheromatous plaques of cHSP60 positive CAD patients suggesting an association of cHSP60 with CAD. | yes |
21,873,790 | Do [ Inflammatory factors promote the development of colorectal cancer ]? | {
"contexts": [
"To study the change of inflammatory factors at different stages of colorectal cancer (CRC).",
"Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, an... | The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC. | yes |
21,894,283 | Does medical journal cover -- an analysis of gendered images and how these might influence best practice? | {
"contexts": [
"Images convey a concept or message to their audience. In medical communications, social expectations and stereotypes can be transferred through language, images and practices just as they can in the lay press. Most medical journals utilise images on their front covers, with the aim of enticing re... | While the images investigated are engaging and sometimes amusing, we explore meanings beyond our engagement as a viewer. The discussion focuses on the need for promotion of best practice, in words and pictures, to model best professional practice. | yes |
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