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1. Introduction
===============
Acetaminophen (APAP) is one of the most common analgesic and antipyretic drug and it has been used as a powerful tool to study mechanisms of hepatotoxicity. Although it is safe at therapeutic doses, overdoses of APAP can cause severe liver injury or acute liver failure and during the la... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction
================
The demand for safety-critical applications (e.g., civil aviation, aircraft landing) using GNSSs has gained extensive and increased interest in recent years. With the advent of the new GNSSs, such as the European Union\'s Galileo system \[[@b1-sensors-15-09404]\], the USA\'s modernize... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#rjw174s1}
============
Human amniotic membrane consists of an epithelial monolayer, a thick basement membrane, and an avascular connective tissue matrix. Placental donations from healthy mothers delivering via elective cesarean section provide the source. The first use was in 1910 and then subsequently ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Investigating the interactions between components as a network provides a common platform to uncover signatures of complex systems^[@R1]-[@R5]^. While this approach has been recently exploited to investigate biological systems of different scales, ranging from interactions between molec... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The efficient and refined division of labor among social insects, such as termites, wasps, ants, and bees, plays a key role in their ecological success ([@B40]). A normal honeybee swarm is usually composed of three types of individuals, namely diploid females that include a queen and worker b... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
According to the most recent catalogue of Ichneumonoidea ([@B12]), the tribe Phygadeuontini of the subfamily Cryptinae (Hymenoptera, Ichneumonidae), comprises 123 genera. [@B11] included 14 subtribes within Phygadeuontini (= Gelini of Townes). Two subtribes, Cephalobaridina and Gnypetomorphin... | {
"pile_set_name": "PubMed Central"
} |
Infectious diseases ranging from respiratory (influenza, common cold, tuberculosis, the respiratory syncytial virus), vector-borne (plague, malaria, dengue, chikungunya, and Zika) to sexually transmitted (the human immunodeficiency virus, syphilis) have historically affected the human population in profound ways. For e... | {
"pile_set_name": "PubMed Central"
} |
DARWIN'S "SPECIAL PROBLEM"
==========================
Eusocial (Greek *eu*: "good/real" + "social") insects include the Hymenoptera (ants, bees, and wasps) and the Isoptera (termites). In honeybees, which is the focus of this perspective, a hive has caste differences; the diploid queen and the haploid drones are the s... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Myocardial infarction (MI) is the leading cause of non-cancer mortality worldwide \[[@CR1]\]. Timely reperfusion approaches, including coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), are standard post-MI treatments, but the limited ability of cardiomyo... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
The in-hospital mortality rate among intensive care patients is 20--30%, and these patients account for 20--50% of all hospital deaths \[[@CR1], [@CR2]\]. Thus, clinicians, hospital administrators, and policy makers are challenged to reduce hospital mortality among critically ill patients... | {
"pile_set_name": "PubMed Central"
} |
[^1]: Dr. Hagopian\'s present address is the Department of Pathology, College of Physicians and Surgeons, New York
| {
"pile_set_name": "PubMed Central"
} |
Introduction
============
In plants, many different species have a direct social impact through such problems as food production, biofuels and ecological services. In the past 20 years, genetic and genomic research have largely focused on a few strategically chosen models but, for many economically and environmentally... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
How organisms respond appropriately to the wide variety of pathogens and antigens they encounter, and how pathogens can subvert the host immune response, has not been fully analyzed. The immune response to infectious agents involves a complex interaction of different cell types,... | {
"pile_set_name": "PubMed Central"
} |
Twenty-two phlebotomine sand fly species (Diptera: Psychodidae) have been reported in Algeria, 12 belonging to the *Phlebotomus* genus and 10 to the *Sergentomyia* genus ([@R1]). Those included in the *Phlebotomus* genus are of medical importance since they comprise recognized or suspected vectors of leishmaniasis and/... | {
"pile_set_name": "PubMed Central"
} |
Elucidating the genetic architecture of a phenotypic trait fundamentally requires that it is, to some degree, heritable. Phenotypic traits with low heritability do not generally require additional explanation as to why quantitative trait loci (QTL) cannot be robustly identified. However, while traits with high heritabi... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
Stroke is the second leading cause of adults\' death and disability in most Western countries.\[[@ref1]\] In 2013, there were almost 25.7 million stroke survivors and 6.5 million deaths from stroke of whom 71% and 51% were with ischemic and hemorrhagic strokes, respectively. During ... | {
"pile_set_name": "PubMed Central"
} |
This work was supported by the Welcome Trust International Senior Research Fellowship in Biomedical Science in Central Europe (Reg. No. 070255/Z/03/Z) and by grants from Grant Agency of Charles University in Prague (No. 0073/2010 and No. 260501). Institutional support was provided by the Research Projects from Ministry... | {
"pile_set_name": "PubMed Central"
} |
**Related research article** Takahashi N, Ogita N, Takahashi T, Taniguchi S, Tanaka M, Seki M, Umeda M. 2019. A regulatory module controlling stress-induced cell cycle arrest in *Arabidopsis*. *eLife* **8**:e43944. doi: [10.7554/eLife.43944](http://doi.org/10.7554/eLife.43944)
When something goes awry during the cell ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
In surgery, post-operative mortality is the most commonly cited outcome variable and to date has been considered the standard measure of quality of care. However, while cardiac operative mortality has fallen (currently 2.1% in the USA ([@CR26]) and 1.5% in the UK (Bridgewater et al. [@CR3... | {
"pile_set_name": "PubMed Central"
} |
Hyperhomocysteinemia (HHcy) has been described as a risk factor for diabetic retinopathy (DR),\[[@ref1]\] especially proliferative DR (PDR) in patients with both type 1 diabetes mellitus (DM)\[[@ref2]\] and type 2 DM.\[[@ref3]\] The study "Role of hyperhomocysteinemia in proliferative diabetic retinopathy: A case--cont... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .309}
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"pile_set_name": "PubMed Central"
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Introduction {#s1}
============
A variety of agents, including environmental toxins or drugs, can cause DNA damage and lead to arrest of DNA replication forks. Arrested forks are among the most serious threats to genomic integrity because they can collapse, break, or rearrange [@pone.0013379-Branzei1], [@pone.0013379-... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The human body consists of numerous cell types that are highly organized into functional units constituting tissues and organs. Expression patterns of genes have been under selection for eons and, as a result, cell types and tissues differ from each other both morphologically and functi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Practicing physicians leave medicine for multiple reasons including illness, family responsibilities, career dissatisfaction or change, substance use, and early retirement \[[@B1], [@B2]\]. Returning to practice can be challenging for many reasons. State licensing boards and hos... | {
"pile_set_name": "PubMed Central"
} |
Significance StatementCurrent good manufacturing practice (cGMP) compliant human pluripotent stem cells (hPSC) have been recently established for clinical application. To validate the capability of such cGMP lines for liver therapy, this article describes their proficiency on advanced hepatocyte production using both c... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Internal fertilization without copulation or another form of prolonged physical contact is a rare reproductive mode among vertebrates. In many newts (Salamandridae), the male deposits a spermatophore (a gelatinous mass topped with a packet of sperm) on the substrate in the water, which ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Autochthonous malaria in the Atlantic Forest occurs mainly in the Southern and Southeastern regions of Brazil, where it is also called "bromeliad malaria" because the immature forms of the main mosquito vectors develop in the water that collects in bromeliads (Bromeliaceae), an abundant g... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .369}
{#sp2 .370}
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"pile_set_name": "PubMed Central"
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Introduction
============
Climate change is altering the environments in which all organisms develop. Plant species can respond to these novel conditions through phenotypic plasticity, adapt through natural selection, or migrate to follow conditions to which they are adapted. The amount of variation in natural populat... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-materials-11-00372}
===============
Today, food technology is constantly evolving in response to different challenges. The changes in consumer demands and the necessity for the production of safe and high-quality foods are responsible for the innovation and improvement of already established foo... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Middle ear surgery for chronic middle ear disease is aimed at eradicating inflammation and preventing disease recurrence. Preservation or improvement of hearing is an additional goal of middle ear surgery. However, surgery for middle ear disease of an ear that has a better hearing level than ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Behaviour change among gay men in the early 1980s in response to the AIDS crisis contributed to a reduction in HIV transmission and that of other sexually transmitted infections (STIs) \[[@B1]\]. However, recent increases in STIs and outbreaks of less common STIs such as syphilis amongst gay men ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
> ***'And now let doctors quit the centre stage***
>
> ***To usher in the prophylactic age'***
>
> From: 'Superfluous Doctors' in: Poems from a Prisoner of War Camp
>
> AL Cochrane 1942
Lifestyle and health-related behaviours are powerful determinants of morbidity and mortality worldwi... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Humans orient their bodies vertically by integrating visual, somatosensory, and vestibular system information in their gravity environment[@r1]^)^. The important cognitive aspects related to this vertical orientation are the subjective visual vertical (SVV), the subjective postural vert... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-materials-13-02377}
===============
Physical properties of Ce-based intermetallic compounds are mainly determined by two competing interactions: Kondo effect, characterized by a temperature $T_{K} \propto exp\left( - \frac{1}{\mid J_{fc}N\left( E_{F} \right) \mid} \right)$, and Ruderman--Kittel-... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Apple (*Malus x domestica* Borkh.) is one of the most cultivated fruit crops in temperate climates. The major constraint of apple cultivation is the apple scab, a fungal disease caused by *Venturia inaequalis*, which can lead to important crop losses if not properly controlled [@pone.00... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Chagas disease, a neglected tropical disease caused by the protozoan parasite *Trypanosoma cruzi*, is considered to be a public health problem [@pone.0097526-Nagajyothi1], [@pone.0097526-Machado1]. Over 10 million people are infected in Latin America and more than 100 million individual... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Liver cancer is considered to be the fourth most lethal cancer globally, and hepatocellular carcinoma (HCC) accounts for 75--85% of liver cancer cases.[@CIT0001] In addition to the high mortality rate, the prognosis and treatment of HCC are suboptimal, most of the patients reach mali... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The activation of Toll-Like Receptors (TLRs), a family of innate immune receptors, is believed to be an important step in the initiation of the inflammatory response raised against numerous pathogens. TLR3 is a mammalian pattern recognition receptor that recognizes double-stranded (ds) RNA as wel... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
The commonly used chemotherapeutic drugs cisplatin and carboplatin are generally considered to exert their cytotoxicity by inducing DNA damage. These drugs interact with DNA to form intra- and inter-strand crosslinks, which must be repaired for the cell to proliferate \[[@R1]\]. Hence, ... | {
"pile_set_name": "PubMed Central"
} |
González‐Varo JP, Arroyo JM, Jordano P. The timing of frugivore‐mediated seed dispersal effectiveness. Mol Ecol. 2019;28:219--231. 10.1111/mec.14850 30151871
1. INTRODUCTION {#mec14850-sec-0001}
===============
Mutualistic interactions constitute an essential element of biodiversity that provides key ecological funct... | {
"pile_set_name": "PubMed Central"
} |
This is the story of the work of women\'s religious orders in setting up a system of health care in New York City in the mid-nineteenth century, and running it successfully for over a hundred years. It is not for the uninitiated in the history of the city, or even those coming for the first time to the worlds of health... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Prostate cancer (PCa) is the second most common cancer diagnosed in men and the fifth leading cause of male cancer deaths worldwide.[@ref1] Despite the availability of various treatment strategies, including surgery, radiotherapy, chemotherapy, and endocrine and targeted therapies, ... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Atherosclerosis is a leading cause of death worldwide ([@BIO041913C4]). The atherosclerotic lesion is characterized by the development of fibroinflammatory lipid plaques in the inner lining of arteries ([@BIO041913C33]). This involves the directed migration of vascular smooth muscle cel... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The ability for cells to organize their interior is ubiquitous across all domains of life. In bacteria, the ParA/MinD family of ATPases has been primarily studied for their ability to segregate genetic cargos, such as chromosomes and plasmids (reviews in [@msz308-B10]; [@msz308-B8]). Less stu... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
*Rickettsia heilongjiangensis* is an obligate intracellular Gram-negative bacterium that belongs to the tick-borne spotted fever group (SFG) of rickettsiae [@pone.0070440-Fournier1]. It was first isolated in 1983 from *Dermacentor silvarum* ticks in Suifenhe, in the Heilongjiang Provinc... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Dynamic cellular processes, such as the response to a signaling event, are governed by complex transcriptional regulatory networks. These networks typically involve a large number of transcription factors (TFs) that are activated in different combinations in order to produce a particula... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec0005}
============
Baroreflex index and hemodynamics {#sec0010}
---------------------------------
Baroceptors, baroreceptors, mechanoreceptors or even mechanoceptors are receptors responsible for the contraction and dilation of blood vessels.[@bib0315] They are located mainly in the carotid sinus[@b... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
*Sclerotinia sclerotiorum* is a plant pathogenic fungus with a remarkably broad host range. An early literature review by [@evx030-B11]) identified 408 species of plants in 278 genera and 75 families that are susceptible to infection by *S. sclerotiorum*. A number of these host species are ec... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
One of the leading causes of water pollution is the unchecked release of wastewater from various industries into water bodies and many other environments \[[@bib0005],[@bib0010]\]. The generation of wastewater is mostly due to rapidly growing industrial sector \[[@bib0015]\] ... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Diabetic neuropathies are neuroendocrine disorders related to chronic hyperglycemia, affecting nerve fibers of the body part in approximately half of all diabetes patients ([@B1][@B2]). The condition of insulin secretory function, insulin sensitivity, insulin resistance (IR), and subsequent h... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Coronary artery disease (CAD) is a progressive atherosclerotic condition and is, together with thrombus formation, the most important underlying mechanism of an acute myocardial infarction (AMI) \[[@CR1]--[@CR4]\].
In addition to platelet activation, thrombin generation and fibrin fo... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
The primary goal in the management of urinary incontinence and erectile dysfunction related to the treatment of prostate cancer is the improvement of long-term quality of life of our patients. Urinary incontinence following radical prostatectomy affects 3%-60% patients and may significantly i... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Epidemiological evidence clearly indicates increased association between breast carcinoma and metabolic disorders (i.e., obesity; type 2 diabetes, metabolic syndrome) \[[@R1]--[@R5]\]. In fact, numerous studies have confirmed a higher risk of bearing breast tumors as well as unfavorable... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
In the United States, there are over 40,000 reported cases of *Salmonella* infection in humans, and approximately 400 deaths are reported annually \[[@pone.0231998.ref001]\]. Consumption of contaminat... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Cellular proteins are subject to oxidative damage and must either be repaired or removed to maintain protein homeostasis. Cells possess two main mechanisms to deal with damaged protein. The first mechanism is the chaperone system. Chaperones such as Hsp70 and Hsp90 bind to exposed hydro... | {
"pile_set_name": "PubMed Central"
} |
Tomczyńska M, Salata I, Bijak M, Saluk‐Bijak J. The potential contribution and role of a blood platelets in autoimmune thyroid diseases. J Cell Mol Med. 2018;22:6386--6390. 10.1111/jcmm.13862
1. INTRODUCTION {#jcmm13862-sec-0001}
===============
The involvement of blood platelets in autoimmune diseases is well docume... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
According to recent global cancer statistics, gallbladder cancer ranks 20th among all cancers, thus it is a relatively uncommon cancer (International Agency for Research on Cancer, 2017). However, previous studies have reported a high incidence of gallbladder cancer in specific coun... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Sexual attractiveness and individual fitness are intimately linked as animals evolve to recognize the traits that indicate high fitness and reproductive potential in their potential mates [@pone.0049799-Andersson1], [@pone.0049799-MaynardSmith1]. Diet is one of the primary environmental... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Airborne bacteria in the indoor environment are the confirmed or presumed causative agents of several infectious diseases, and their components are linked to the development and exacerbation of chronic respiratory illness including asthma [@pone.0034867-Fields1], [@pone.0034867-Douwes1]... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Multiple sclerosis (MS) is the most-common immune-mediated demyelinating disease of the central nervous system, with a wide range and heterogeneous clinical presentations with no definitive symptoms, but with certain highly characteristic symptoms and signs such as unilateral subacute visual ... | {
"pile_set_name": "PubMed Central"
} |
Erratum {#Sec1}
=======
After the publication of the article \[[@CR1]\], the authors realised it contained an error with the Methods section. The following paragraph should be deleted from the original article:
Cell proliferation assay {#Sec2}
------------------------
Proliferation was measured using Delfia cell pro... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Diabetes mellitus represents an expanding pandemic that contributes markedly to worldwide morbidity and mortality. The world prevalence of diabetes among adults (aged 20--79 years) will be 6.4%, affecting 285 million adults, in 2010 and will increase to 7.7% and 439 million adul... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
While online price comparison websites have burgeoned, there is scant understanding of how they influence online consumer (eSwitching) behavior. This study addresses this gap in the literature by investigating the influence of price comparison websites on online switching behavior. Wh... | {
"pile_set_name": "PubMed Central"
} |
######
Supplementary figures, legends, and table
######
Click here for additional data file.
######
Countries in which eligible trials had been done
######
Click here for additional data file.
Introduction
============
The predominant share of the global burden of disease is concentrated in less developed ... | {
"pile_set_name": "PubMed Central"
} |
Correction to: *Scientific Reports* 10.1038/s41598-017-06666-2, published online 26 July 2017
This Article contains errors in Table [1](#Tab1){ref-type="table"} where the RT-qPCR Primer Sequences for the following genes,Table 1RT-qPCR Primer Sequences.GeneAccession \#ForwardReverse*ACAN*M_55172AGGGCGAGTGGAATGATGTTGGTG... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Mostly, the amino acid sequence of a protein is conserved in order to maintain its function and structure. However, the conservation may also be caused by the selection at the nucleic acid level due to essential cis-acting sequences located in the protein-coding region. Thus, certain regions ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
For bone reconstruction such as skull base reconstruction after tumor resection, an interconnected porous structure is critical to mimicking the bone extracellular matrix \[[@CR1]--[@CR8]\]. The pore size, porosity, and pore interconnectivity of porous bone scaffolds determine their perfo... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction {#s1}
================
The lead chalcogenides PbTe, PbSe and PbS have undergone much detailed study as thermoelectrics in recent years. These are all narrow band gap semiconductors, forming in the cubic rocksalt structure, that can be readily doped both p-type and n-type. Although in earlier years the... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Whilst adolescence and young adulthood is often thought of as a period of relative good health, burden of disease studies indicate that10--24 year olds remain at substantial risk of morbidity and mortality \[[@CR1]\]. Burden of disease in this age group is not driven by physical illness, ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
*Orcula* [@B30], the type genus of the family Orculidae is a group of small (5--10 mm), pulmonate land snails with ovate--cylindrical shells and 3--4 lamellae within the aperture and the body whorl. Taxa are primarily found in mountainous regions in relatively humid habitats, most commonly in... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Almost all available antidepressants bring about their effects by increasing monoamine neurotransmission, and many drugs that increase monoamines in the synaptic cleft have been shown to have antidepressant properties.^[@bib1]^ Despite the considerable noise in placebo-controlled clinical tri... | {
"pile_set_name": "PubMed Central"
} |
**What do we already know about this topic?** Although there is considerable interest in possibilities to enhance informal care, the risk of a negative health impact among informal caregivers should be taken into account especially when the intensity of the care increases.
**How does your research contribute to the fi... | {
"pile_set_name": "PubMed Central"
} |
Data were obtained from a third party, and are freely available from the following URL: <http://www.occ.gov/topics/capital-markets/financial-markets/trading/derivatives/derivatives-quarterly-report.html>.
Introduction {#sec001}
============
After the financial crisis of 2008 the systemic risk resulting from OTC (over... | {
"pile_set_name": "PubMed Central"
} |
The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information.
Introduction {#s1}
============
Human noroviruses (HuNoV) are the most common cause of acute viral gastroenteritis worldwide [@pone.0106805-Glass1].... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Post hysterectomy complications at the vault site such as a bleeding incident can be commonly observed at a short term postoperative period. Other delayed complications often occur as a hematoma, granuloma, keloid, incisional hernia, and or vascular formation at the vault \[[@B1][@B2]\]. Many... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Postoperative adjuvant systemic therapy is considered to be an integral component of the management of primary breast cancer \[[@R1], [@R2]\]. The decision to give adjuvant chemotherapy is based on prognostic and predictive factors, such as age, axillary lymph node status, histologic gr... | {
"pile_set_name": "PubMed Central"
} |
THE PRE-TRAVEL CONSULTATION {#subchapter1}
===========================
Acosta
Rebecca W.
The pre-travel consultation is a risk-based assessment process that provides a guide to prioritizing and customizing pre-travel health care to the traveler\'s itinerary, risks, and needs. The goal of the pre-travel consultation ... | {
"pile_set_name": "PubMed Central"
} |
ANNOUNCEMENT {#s1}
============
Achromobacter species are Gram-negative bacilli commonly found in soil and water but also are associated with human clinical samples. Relevant species include Achromobacter piechaudii, Achromobacter spanius, and Achromobacter marplatensis ([@B1], [@B2]). Here, we report the complete gen... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Clinical trial participants in sub-Saharan Africa often have limited understanding of the study information provided during the informed consent process. Low literacy and the difficulty of presenting information in local languages with no standard written form are contributory factors.[@R1]^,... | {
"pile_set_name": "PubMed Central"
} |
###### Strengths and limitations of this study
- Systematic synthesis of data on disease burden and existing coverage of interventions relevant to diarrhoea, malaria and HIV prevention.
- Three alternative ways to prioritise countries for integrated prevention campaign (IPC) implementation in a visually accessibl... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .230}
{#sp2 .231}
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"pile_set_name": "PubMed Central"
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INTRODUCTION {#S1}
============
Acetylation of lysine residues in histone tails activates gene transcription by several mechanisms, including promotion of an open chromatin structure as well as attracting positively acting transcription factors to the genome^[@R1]--[@R5]^. Histone deacetylases (HDACs) catalyze the rev... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1_1}
============
Undiagnosed asthmatic patients who present with cough, wheezing, shortness of breath and other common respiratory symptoms are sometimes mistakenly diagnosed with upper or lower respiratory tract infections \[[@B1]\]. In children with asthma-like symptoms, such as recurrent episodes... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Bipolar disorders are chronic conditions with lifetime prevalence rates of 0.6% for bipolar I and 0.4% for bipolar II.[@b1-ndt-13-733] Although bipolar disorders have a strong genetic etiology,[@b2-ndt-13-733] mood symptoms are significantly related to psychosocial events.[@b3-ndt-13-733] Thu... | {
"pile_set_name": "PubMed Central"
} |
###### Strengths and limitations of this study
- Strengths include a longitudinal design, with first assessment within 3 weeks after arrival to the host country, and repeated measures.
- Use of computer-based assessment with audio-translations throughout the study.
- Selection of participants was limited to th... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Deficient androgen exposure during fetal masculinization results in smaller sized testes, prostate, seminal vesicles, and penis in adulthood and is associated with an increased risk of hypospadias and lower testosterone levels \[[@B1],[@B2],[@B3],[@B4]\]. It is well established that normal pe... | {
"pile_set_name": "PubMed Central"
} |
I[NTRODUCTION]{.smallcaps} {#sec1-1}
==========================
The World Health Organization (WHO)in 1948 defined health as "A state of complete physical, mental, and social well-being and not merely an absence of disease or infirmity."\[[@ref1]\] It defined mental health as "a state of well-being in which every indi... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Chansu is a traditional Chinese medicine extracted from parotoid glands of the Chinese toad (*Bufo gargarizan*). It has been widely used for the treatment of inflammation, anaesthesia and arrhythmia in China, Japan and other Asian countries for centuries \[[@CR1]\]. Cinobufagin (CBF) is a... | {
"pile_set_name": "PubMed Central"
} |
Significance Statement {#s1}
======================
Cortico-basal ganglia circuits control a range of neurobiological functions, ranging from motor control and reward to cognition. The functional diversity of cortico-basal ganglia circuits rests on their diverse inputs from the cerebral cortex. It is likely that the h... | {
"pile_set_name": "PubMed Central"
} |
The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.
Introduction {#s1}
============
The stoichiometric proportions of elements in plant and animal tissues differ substantially, which causes all ... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are found within the paper and its Supporting Information files.
Introduction {#sec001}
============
The human DEK oncoprotein is a predominantly chromatin-bound factor that regulates nuclear processes such as chromatin architecture, epigenetics, transcription and DNA repair \[[@pgen.1007227.ref001]... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Acute myeloid leukaemia (AML), one of the most common and deadliest forms of proliferative neoplasms, is established through a stepwise acquisition of genetic and epigenetic alterations that result in the malignant transformation of haematopoietic progenitor cells ([@bib15]; [@bib21]). ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
In many low- and middle-income countries, the private commercial sector plays an important role in the provision of malaria treatment \[[@B1]-[@B6]\]. A study on the market for anti-malarial drugs in six developing countries found that private providers were responsible for around 40% of all anti... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Does exercise enhance cognitive functioning in human beings? Meta-analyses have provided support for the beneficial effect of exercise on cognitive performance with effect sizes (*g*) ranging from 0.097 for acute exercise (Chang et al., [@B11]) to 0.158 for chronic exercise (Smith et al... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
==================
For the structure at 200 K, see: Seidel *et al.* (2010[@bb10]). For the 2-chlorophenol solvate of cyclic tetrameric ZnTPyP, see: Lipstman & Goldberg (2010[@bb8]). For a review article on structural motifs in coordination polymers of the 5,10,15,20-tetra4-pyridylporphyr... | {
"pile_set_name": "PubMed Central"
} |
Is There Really a Male Bias? {#s1}
============================
The diagnosis of classic autism and Asperger Syndrome (AS), known as Autism Spectrum Conditions (ASC), rests on difficulties in reciprocal social interaction and communication, alongside strongly repetitive behavior and unusually narrow interests [@pbio.1... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Surimi, a stabilized myofibrillar protein from fish, is the primary ingredient in fish paste or imitation crab. It is prepared by separation, washing, and mincing to eliminate undesirable blood, lipids, enzymes, and sarcoplasmic proteins ([@b41-ajas-27-1-115-13]; [@b28-ajas-27-1-115-13]). In ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Malignant pleural mesothelioma (MPM) is a lethal cancer arising from pleura mesothelial cells, showing a close association with previous exposure to asbestos. This tumor is characterized by long latency period (20--30 years) and slow growth which cause late diagnosis, poor prognosis, an... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Globally, thousands of mushroom poisonings are reported each year \[[@pone.0231781.ref001]--[@pone.0231781.ref009]\]. Approximately 80% of the mushroom poisonings involve unknown mushroom species. The pois... | {
"pile_set_name": "PubMed Central"
} |
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