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Introduction {#sec1-1}
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Infliximab (IFX), a chimeric anti-TNFα antibody, is effective in inducing and maintaining remission in a considerable proportion of IBD patients refractory to any other treatments \[[@ref1],[@ref2]\]. However, 8-12% of adult and/or pediatric patients fail to respond to the induction... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
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Hepatitis B virus (HBV) is still a major global health problem, with an estimated 257 million people worldwide that are chronically infected with HBV ([@B1]). HBV, together with duck hepatitis B virus (DHBV) and several other related animal viruses, belongs to the *Hepadnaviridae* famil... | {
"pile_set_name": "PubMed Central"
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Koolstra K, Beenakker J‐WM, Koken P, Webb A, Börnert P. Cartesian MR fingerprinting in the eye at 7T using compressed sensing and matrix completion‐based reconstructions. Magn Reson Med. 2019;81:2551--2565. 10.1002/mrm.27594 30421448
**Funding information**
This project was partially funded by the European Research C... | {
"pile_set_name": "PubMed Central"
} |
Historical conceptualizations of depression
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There is a long tradition in phenomenologlcal psychopathology that stresses basic bodily alterations as core features of depressive states. Thus, Wernicke used the term "vital feelings" to describe certain somatic symptoms occurrin... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Irinotecan (CPT-11, Campto®) -- a semisynthetic, water-soluble derivative of the plant alkaloid camptothecin -- is the standard of care in the treatment of advanced colorectal cancer when 5-fluorouracil (5-FU)-based therapy has failed ([Cunningham *et al*, 2001](#bib5){ref-type="other"}). Phase II trials have demonstra... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
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Acute aortic dissection (AAD) is a relatively uncommon medical emergency with a high mortality after symptom onset. The mortality of acute type A aortic dissection increases by 1--2% per hour during the first 48 h if no treatment is received \[[@cit0001]\]. Meanwhile, other common cau... | {
"pile_set_name": "PubMed Central"
} |
Background
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Polysaccharide-rich fungi and plants have been employed for centuries by cultures around the world for their dietary and medicinal benefits \[[@B1]-[@B5]\]. Often thought to merely support normal bowel function and blood glucose and lipid levels \[[@B6]-[@B8]\], certain polysaccharides have attra... | {
"pile_set_name": "PubMed Central"
} |
Introduction
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Phytogenic feed additives (PFA) have attracted a lot of attention in recent years. When used in diets, these substances exhibit antioxidative properties and antimicrobial activity, improve nutrient absorption, and could ultimately improve animal performance ([@bib26]; [@bib30]; [@bib37]). PFA... | {
"pile_set_name": "PubMed Central"
} |
Updated to correct an editorial error in the element named in the deck.
The largest industrial application of olefin metathesis today is the synthesis of propylene from ethylene and butenes^[@ref1]^ employing WO~3~ on SiO~2~, a relatively long-lived and regenerable catalyst that operates at 350--400 °C. It is widely p... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
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Cytokines are a broad and loose group of small cell-signaling proteins that play important roles in cell growth, proliferation, differentiation, apoptosis, angiogenesis, immunity and inflammatory response. They include interferons (IFN), interleukins (IL), chemokines, lymphok... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
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Evidence-based veterinary medicine (EVM) can be defined as 'the use of current best evidence in making clinical decisions' ([@R4]). Additionally, when making evidence-based decisions, the circumstances of the patient alongside the circumstances and values of the owner must also be taken... | {
"pile_set_name": "PubMed Central"
} |
**Zhang X, Bao S, Lai D, Rapkins RW, Gillies MC. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes 2008;57:1026--1033**
In the print version of the article listed above, the second aff... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
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Interactions of integral membrane proteins with their surrounding lipid environment play a key role in stabilising their structure and influencing their activity. To obtain insight into the nature and type of interactions occurring between lipids and integral membrane proteins ... | {
"pile_set_name": "PubMed Central"
} |
(J Am Heart Assoc. 2017;6:e007026 DOI: 10.1161/JAHA.117.007026.)29042422
Clinical PerspectiveWhat Is New?In this nonrandomized, retrospective, observational study of patients undergoing cardiac resynchronization therapy (CRT) with quadripolar (QUAD) and non‐QUAD left ventricular leads, programmed to biventricular, sin... | {
"pile_set_name": "PubMed Central"
} |
Background
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Diamond holds a variety of extraordinary physical and chemical properties, facilitating its possible applications in novel functional devices \[[@B1]-[@B7]\]. As a semiconductor with a wide bandgap of 5.47 eV, it is a promising candidate for short-wavelength optoelectronic devices such as ultravi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
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Nuclear magnetic resonance spectroscopy (NMR, or MRS) has enormous potential for the study of biochemical and physiological changes in cancer tissues, due to its noninvasive nature and the large quantity of specific molecular information it can generate. Despite the sensitivity ... | {
"pile_set_name": "PubMed Central"
} |
Diet is believed to be the single most important contributor to colonic carcinogenesis ([Tomatis *et al*, 1990](#bib25){ref-type="other"}). Experimental data have shown that saturated fatty acids (SFAs) and n-6 polyunsaturated fatty acids (PUFAs) have tumour-enhancing properties in the colon ([Reddy and Maeura, 1984](#... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
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Stroke is the second most common cause of death in developed countries and thus is a major health problem \[[@B1]\]. According to the 2009 Annual Public Health Report by the Korean National Statistical Office, cerebrovascular disease, or stroke, was the second-leading cause of d... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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Small heat-shock proteins (sHSPs) are a diverse family of proteins that share a conserved ≈ 90-residue α-crystallin domain (ACD) that is flanked by variable N- and C-terminal regions (Basha et al. [@CR3]; Hilton et al. [@CR17]; McHaourab et al. [@CR28]). Although sHSPs are relatively ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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Alcohol use disorders (AUD) are common and associated with significant morbidity and mortality \[[@CR1]--[@CR3]\], but are substantially undertreated. In 2013, 16.6 million U.S. adults met diagnostic criteria for an AUD, but research suggests only 7.8% received any formal treatment \[... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and ranks the third highest cause of cancer-related deaths worldwide \[[@R1], [@R2]\]. The resection rate of HCC has increased over decades due to the improvements in early diagnostic methods and surgical techniqu... | {
"pile_set_name": "PubMed Central"
} |
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