Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo. | The effect of O6-methylguanine (O6-MeG) on the therapeutic efficiency of 1-methyl-1-nitrosourea (MNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against the murine L1210 leukemia and B16 melanoma was studied in vivo. Although the level of O6-alkylguanine-DNA alkyltransferase (AGT) in L1210/BCNU leukemia cells was... | ['Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Carmustine', 'DNA Damage', 'DNA, Neoplasm', 'Drug Interactions', 'Drug Resistance', 'Guanine', 'Leukemia L1210', 'Methylnitrosourea', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Neoplasm Transplantation', 'Nucleic Acid Conformation', 'Time Factors'] | 1,958,863 | [['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.065.950.594.247', 'D02.654.692.247'], ['G05.200'], ['D13.444.308.425'], ['G07.690.773.968'], ['G07.690.773.984'], ['D03.633.100.759.758.399.454'], ['C04.557.337.372.594', 'C04.619.531.594'], ['D02.065.950.594.490', 'D02.654.692.480'], ['B01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Initial state perturbations as a validation method for data-driven fuzzy models of cellular networks. | BACKGROUND: Data-driven methods that automatically learn relations between attributes from given data are a popular tool for building mathematical models in computational biology. Since measurements are prone to errors, approaches dealing with uncertain data are especially suitable for this task. Fuzzy models are one s... | ['Computational Biology', 'Computer Simulation', 'Fuzzy Logic', 'Gene Regulatory Networks', 'Humans', 'Systems Biology'] | 30,241,464 | [['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['E05.599.250', 'K01.752.448.250', 'L01.224.050.375.250'], ['G05.360.080.689.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.273.180.800']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The differential protein expression profiles and immunogenicity of tachyzoites and bradyzoites of in vitro cultured Neospora caninum. | We report a study on the variations in the protein expression profiles of tachyzoites and bradyzoites of Neospora caninum. The in vitro stage conversion of N. caninum-infected Vero cells was induced by continuous treatment of infected cultures with 70 muM sodium nitroprusside (SNP) for up to 9 days. The stage conversio... | ['Animals', 'Blotting, Western', 'Chlorocebus aethiops', 'Electrophoresis, Polyacrylamide Gel', 'Fluorescent Antibody Technique', 'Fungal Proteins', 'Microscopy, Electron, Transmission', 'Molecular Weight', 'Neospora', 'Nitroprusside', 'Proteome', 'Vero Cells'] | 18,597,117 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.196.401.402', 'E05.301.300.319'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wrist actigraphy in insomnia. | To assess the use of actigraphy in evaluating insomnia, 36 patients with a serious complaint of insomnia slept 3 nights each in the laboratory, where the usual polysomnograms (PSGs) were obtained as well as actigraphic assessments of their sleep. Patients also wore actigraphs for 7 days at home, were extensively interv... | ['Adult', 'Aged', 'Analysis of Variance', 'Clinical Laboratory Techniques', 'Female', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Sleep', 'Sleep Initiation and Maintenance Disorders', 'Wrist'] | 1,519,002 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.225', 'E05.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['F02.830.855', 'G11.561.803'], ['C10.886.425.800.800', 'F03.870.400.800.800'], ['A01.378.800.875']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Guinea-pig lung adenylyl and guanylyl cyclase and PDE activities associated with airway hyper- and hypo-reactivity following LPS inhalation. | The relationships between changes in in vivo airway reactivity and levels cyclicAMP and cyclicGMP were determined in guinea-pig lungs after exposure to inhaled lipopolysaccharide (LPS). After LPS (30 microg.ml(-1), 1 h), guinea-pigs displayed in vivo airway hyperreactivity (AHR) at 1 h and hyporeactivity (AHOR) at 48 h... | ['1-Methyl-3-isobutylxanthine', 'Adenylyl Cyclases', 'Administration, Inhalation', 'Animals', 'Bronchi', 'Bronchial Hyperreactivity', 'Bronchoconstriction', 'Cyclic AMP', 'Cyclic GMP', 'Guanylate Cyclase', 'Guinea Pigs', 'Histamine', 'Lipopolysaccharides', 'Lung', 'Male', 'Phosphoric Diester Hydrolases'] | 15,607,329 | [['D03.633.100.759.758.824.751.500'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['E02.319.267.050'], ['B01.050'], ['A04.411.125'], ['C08.127.210'], ['G09.772.705.700.080'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.633.100.759.646.454.16... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of extent of resection on survival in high-risk neuroblastoma: A systematic review and meta-analysis. | BACKGROUND: Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor. Many studies designed to elaborate the association between the extent of resection (EOR) and outcome have reported conflicting results. We performed a meta-analysis to assess whether greater EO... | ['Biopsy', 'Humans', 'Neoplasm, Residual', 'Neuroblastoma', 'Prognosis', 'Progression-Free Survival', 'Risk Factors', 'Survival Rate'] | 30,262,202 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.700', 'C23.550.727.700'], ['C04.557.465.625.600.590.650.550', 'C04.557.470.670.590.650.550', 'C04.557.580.625.600.590... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Isolation and translation in vitro of poly(A)+RNA from the free-living nematode Panagrellus silusiae. | Polysomal RNA was isolated from the free-living nematode Panagrellus silusiae. Passage of this RNA through a cellulose column resulted in the fractionation of the input RNA into poly(A)-RNA (ca. 97.5% of the total) and poly(A)+ RNA (ca. 2.5% of the total). RNase digestion, followed by polyacrylamide gel electrophoresis... | ['Animals', 'Kinetics', 'Nematoda', 'Plants', 'Poly A', 'Polyribosomes', 'Protein Biosynthesis', 'RNA, Ribosomal', 'Triticum'] | 445,222 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A phase II pharmacological study of leuprolide acetate 6-month depot, TAP-144-SR (6M), in treatment-Nazve patients with prostatic cancer who received a single subcutaneous or intramuscular injection]. | The aim of this phase II study was to evaluate the pharmacokinetics, pharmacodynamics, efficacy, and safety of a 6- month depot formulation of a luteinizing hormone-releasing hormone (LH-RH) agonist, TAP-144-SR (6M), in Japanese treatment-na?ve patients with prostatic cancer. Each subject received a single subcutaneous... | ['Aged', 'Humans', 'Injections, Intramuscular', 'Injections, Subcutaneous', 'Leuprolide', 'Male', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Testosterone'] | 24,917,003 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['E02.319.267.530.620'], ['D06.472.699.327.740.320.400', 'D12.644.400.400.740.320.400', 'D12.644.456.460.480', 'D12.644.548.365.740.320.400', 'D12.776.631.650.405.740.320.400'], ['D08.811.277.656.300.760.442.750', 'D08.811.2... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
High expression of microRNA-130b correlates with poor prognosis of patients with hepatocellular carcinoma. | BACKGROUND: Whether microRNA-130b(miR-130b) can serve as a prognostic biomarker of hepatocellular carcinoma (HCC) has not been investigated. In the present study, we investigated the feasibility of miR-130b as a novel prognostic biomarker for HCC.METHODS: We retrospectively investigated 97 patients diagnosed with HCC w... | ['Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Disease Progression', 'Disease-Free Survival', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Kaplan-Meier Estimate', 'Liver Neoplasms', 'Male', 'MicroRNAs', 'Middle Aged', 'Prognosis', 'Proportional Hazards Models', 'Retrospective Studies', 'Survival ... | 25,123,453 | [['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C23.550.291.656'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['G05.308.370'], ['B01.050.150.900.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (2)--Single oral dose toxicity study in dogs]. | Cefmatilen hydrochloride hydrate (S-1090) was administered at 500 and 1000 mg potency/kg once orally to beagle dogs. No deaths occurred. Vomiting, diarrhea or mucous feces occurred on the dosing day, and reddish-brown feces (due to chelated products of S-1090 and its decomposition products with Fe3+ in the diet) were a... | ['Administration, Oral', 'Animals', 'Blood Chemical Analysis', 'Body Weight', 'Cephalosporins', 'Dogs', 'Eating', 'Male', 'Occult Blood', 'Urinalysis'] | 11,400,318 | [['E02.319.267.100'], ['B01.050'], ['E01.370.225.124.100', 'E05.200.124.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.203.65... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aim44p regulates phosphorylation of Hof1p to promote contractile ring closure during cytokinesis in budding yeast. | Whereas actomyosin and septin ring organization and function in cytokinesis are thoroughly described, little is known regarding the mechanisms by which the actomyosin ring interacts with septins and associated proteins to coordinate cell division. Here we show that the protein product of YPL158C, Aim44p, undergoes sept... | ['Cell Cycle Proteins', 'Cytokinesis', 'Gene Deletion', 'Gene Expression Regulation, Fungal', 'Intracellular Signaling Peptides and Proteins', 'Microtubule-Associated Proteins', 'Myosin Heavy Chains', 'Phosphorylation', 'Protein Binding', 'Protein Transport', 'Protein-Serine-Threonine Kinases', 'Saccharomyces cerevisia... | 24,451,263 | [['D12.776.167'], ['G04.144.220.250'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.330'], ['D12.644.360', 'D12.776.476'], ['D12.776.220.600.450', 'D12.776.631.560'], ['D05.750.078.730.475.100', 'D08.811.277.040.025.193.750.249', 'D12.776.210.500.600.100', 'D12.776.220.525.475.100'], ['G02.111.665', 'G02.607.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM). | PURPOSE: To investigate the prevalence and features of cystoid spaces (CS) in patients with confirmed genetic diagnosis of choroideremia (CHM) using swept source optical coherence tomography (OCT).METHODS: We retrospectively reviewed CHM patients examined at the Regional Reference Center for Hereditary Retinal Degenera... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Choroid', 'Choroideremia', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Retinal Pigment Epithelium', 'Retrospective Studies', 'Tomography, Optical Coherence', 'Visual Acuity', 'Visual Fields', 'Young Adult'] | 31,654,189 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['A09.371.894.223'], ['C11.270.142', 'C11.941.160.300', 'C16.320.290.142', 'C16.320.322.092'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.11... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NMDA and AMPA receptors mediate intracellular calcium increase in rat cortical astrocytes. | AIM: To study the effect of glutamate on the intracellular calcium signal of pure cultured rat astrocytes and the role of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in the procedure.METHODS: The fluorescence of calcium was measured by Fura-2/AM (F(345)/F(3... | ['2-Amino-5-phosphonovalerate', '6-Cyano-7-nitroquinoxaline-2,3-dione', 'Animals', 'Animals, Newborn', 'Astrocytes', 'Calcium', 'Cells, Cultured', 'Cerebral Cortex', 'Glutamic Acid', 'N-Methylaspartate', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, AMPA', 'Receptors, N-Methyl-D-Aspartate', 'alpha-Amino-3-hydroxy-5-methy... | 15,169,621 | [['D12.125.070.950.100', 'D12.125.740.025'], ['D03.633.100.857.160'], ['B01.050'], ['B01.050.050.282'], ['A08.637.200', 'A11.650.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D12.125.067.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variants of NOS1, NOS2, and NOS3 genes in asthmatics. | Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No ass... | ['Alleles', 'Asthma', 'Chromosome Mapping', 'Chromosomes, Human, Pair 12', 'Chromosomes, Human, Pair 17', 'Chromosomes, Human, Pair 7', 'Genetic Variation', 'Humans', 'Immunoglobulin E', 'Introns', 'Microsatellite Repeats', 'Minisatellite Repeats', 'Nerve Tissue Proteins', 'Nitric Oxide Synthase', 'Nitric Oxide Synthas... | 10,673,365 | [['G05.360.340.024.340.030'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.393.183'], ['A11.284.187.520.300.325.360', 'G05.360.162.520.300.325.360'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['A11.284.187.520.300.325.335', 'G05.360.162.520.300.325.335'], ['G05.3... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Chromosomal aberrations in adenomatoid hyperplasia of palatal minor salivary gland. | Adenomatoid hyperplasia of minor salivary glands is rare, idiopathic, and benign, and typically presents as a tumour-like mass in the hard or soft palate. Its exact nature is not clear and histological examination usually shows an excess of normal-appearing minor salivary glands. To our knowledge, cytogenetic analysis ... | ['Chromosome Aberrations', 'Chromosome Breakage', 'Chromosomes, Human, Pair 14', 'Chromosomes, Human, Pair 2', 'Chromosomes, Human, Pair 21', 'Chromosomes, Human, Pair 22', 'Epithelium', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperplasia', 'Middle Aged', 'Palate, Hard', 'Salivary Ducts', 'Salivary Gland Neoplasms', ... | 22,571,812 | [['C23.550.210', 'G05.365.590.175'], ['C23.550.210.170', 'G05.200.210.170', 'G05.365.590.175.175'], ['A11.284.187.520.300.370.380', 'G05.360.162.520.300.370.380'], ['A11.284.187.520.300.235.245', 'G05.360.162.520.300.235.245'], ['A11.284.187.520.300.505.510', 'G05.360.162.520.300.505.510'], ['A11.284.187.520.300.505.51... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cysteine and crocin oxidation catalyzed by horseradish peroxidase. | The amino acid cysteine is oxidized by horseradish peroxidase, and the water-soluble carotenoid crocin is bleached by cooxidation. The monophenol p-hydroxyacetophenone stimulates oxygen uptake, cysteine oxidation and crocin bleaching, whereas its concentration does not change. Superoxide dismutase significantly enhance... | ['Carotenoids', 'Cysteine', 'Horseradish Peroxidase', 'Kinetics', 'Oxidation-Reduction', 'Peroxidases', 'Substrate Specificity'] | 2,707,627 | [['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D08.811.682.732.512'], ['G01.374.661', 'G02.111.490'], ['G02.700', 'G03.295.531'], ['D08.811.682.732'], ['G02.111.835']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Treatment of beta-thalassemia with Bushen Yisui therapy: a randomized controlled trial]. | OBJECTIVE: To investigate the efficacy and safety of Yisui Shengxue Granule (YSSXG), a compound traditional Chinese herbal medicine, in treating beta-thalassemia.METHODS: A randomized single-blinded trial was designed. Sixty patients with beta-thalassemia were divided into two groups: 30 patients in YSSXG-treated group... | ['Adolescent', 'Child', 'Child, Preschool', 'Drugs, Chinese Herbal', 'Female', 'Humans', 'Male', 'Phytotherapy', 'Single-Blind Method', 'Treatment Outcome', 'beta-Thalassemia'] | 17,352,867 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.755'], ['E05.318.370.850', 'N05.715.360.325.730', 'N06.850.520.445.850'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['C15.378.071.141.150.875.15... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chronic pancreatitis: a complication of systemic lupus erythematosus. | Systemic lupus erythematosus (SLE), an autoimmune disease with multisystem involvement, has been reported to be associated with a number of gastrointestinal complications. Acute pancreatitis is an unusual manifestation of this disorder. This report presents two cases of patients with SLE who developed chronic pancreati... | ['Adult', 'Chronic Disease', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Pancreatitis'] | 8,425,705 | [['M01.060.116'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.300.480', 'C20.111.590'], ['C06.689.750']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synthesis of colour tunable lanthanide-ion doped NaYF4 upconversion nanoparticles by controlling temperature. | A simple and general method is reported to tune the multicolour output of lanthanide-ion doped NaYF(4) upconversion nanoparticles within a given composition by controlling the reaction temperature in the thermolysis procedure. | ['Color', 'Fluorides', 'Lanthanoid Series Elements', 'Nanoparticles', 'Temperature', 'X-Ray Diffraction', 'Yttrium'] | 20,414,492 | [['G01.590.540.199'], ['D01.248.497.158.380', 'D01.303.350.300'], ['D01.268.558.362', 'D01.552.550.399'], ['J01.637.512.600'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965'], ['D01.268.558.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Calcium is a key constituent for maintaining the in vitro properties of platelets suspended in the bicarbonate-containing additive solution M-sol with low plasma levels. | BACKGROUND: Commercially available additive solutions (ASs) require 30% to 35% plasma for optimal storage of platelets (PLTs). PLTs suspended in M-sol, a bicarbonate-based experimental platelet additive solution (PAS), maintain in vitro PLT properties during storage with low levels of plasma (< or =5%).STUDY DESIGN AND... | ['Blood Platelets', 'Blood Preservation', 'Calcium', 'Humans', 'Sodium Bicarbonate', 'Suspensions'] | 20,030,790 | [['A11.118.188', 'A15.145.229.188'], ['E02.792.833.230', 'E05.760.833.230'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.200.275.150.100.800', 'D01.857.625'], ['D20.280.810', 'D26.255.165.810']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion. | Effective intraductal delivery of the enzyme collagenase into the pancreas is crucial to the subsequent ability to isolate viable islets. Most clinical islet transplant centers load the enzyme into the pancreas by retrograde injection using a syringe following cannulation of the pancreatic duct. An alternative approach... | ['Adenosine', 'Adult', 'Allopurinol', 'Brain Death', 'Cadaver', 'Cell Separation', 'Collagenases', 'Glutathione', 'Humans', 'Insulin', 'Islets of Langerhans', 'Organ Preservation Solutions', 'Pancreatic Ducts', 'Perfusion', 'Raffinose', 'Thermolysin', 'Tissue Donors', 'Tissue Preservation'] | 10,442,741 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['M01.060.116'], ['D03.633.100.759.160'], ['C10.228.140.151', 'C10.597.606.358.800.200.100', 'C23.550.260.159'], ['C23.550.260.224'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.20... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats. | Melanocortin-3 and 4 receptors (MC3R and MC4R) can regulate energy homeostasis, but their respective roles especially the functions of MC3R need more exploration. Here Mc3r and Mc4r single and double knockout (DKO) rats were generated using CRISPR-Cas9 system. Metabolic phenotypes were examined and data were compared s... | ['Adipose Tissue, White', 'Animals', 'Animals, Genetically Modified', 'Body Weight', 'Drinking', 'Eating', 'Energy Metabolism', 'Female', 'Gene Knockout Techniques', 'Glucose', 'Homeostasis', 'Kidney', 'Lipids', 'Liver', 'Male', 'Rats', 'Rats, Mutant Strains', 'Rats, Sprague-Dawley', 'Receptor, Melanocortin, Type 3', '... | 27,713,523 | [['A10.165.114.830'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.203.650.283.249', 'G10.261.330.249'], ['G07.203.650.283', 'G10.261.330'], ['G03.295'], ['E05.393.335.750'], ['D09.947.875.359.... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Air pollution and daily clinic visits for migraine in a subtropical city: Taipei, Taiwan. | This study was undertaken to determine whether there was an association between air pollutant levels and daily clinic visits for migraine in Taipei, Taiwan. Daily clinic visits for migraine and ambient air pollution data for Taipei were obtained for the period 2006-2011. The relative risk of clinic visits for migraine ... | ['Air Pollutants', 'Ambulatory Care', 'Cities', 'Cross-Over Studies', 'Environmental Exposure', 'Environmental Monitoring', 'Female', 'Humans', 'Male', 'Migraine Disorders', 'Seasons', 'Taiwan'] | 25,965,190 | [['D27.888.284.101'], ['E02.760.106', 'N02.421.585.106'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.546.399.750'], ['G01... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes. | The most sensitive technique for the detection of germline mutations is exon by exon sequencing of the gene under investigation using genomic DNA as a template for analysis. This approach, however, has cost and sensitivity limitations that can, at least in part, be overcome by RNA-based analysis. Germline mutations of ... | ['Adaptor Proteins, Signal Transducing', 'Alternative Splicing', 'Amino Acid Substitution', 'Arginine', 'Base Pair Mismatch', 'Carrier Proteins', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'DNA Repair', 'DNA-Binding Proteins', 'Germ-Line Mutation', 'Humans', 'Lysine', 'MutL Protein Homolog 1', 'MutS Homolog 2 Pro... | 11,139,242 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['E05.393.420.601.035', 'G05.558.109'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G05.365.590.060'], ['D12.776.157'], ['C04.588.274.476.411.307.190', 'C04.700.250', 'C06.301.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. | OBJECTIVE: Both adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in pati... | ['Adenomyosis', 'Adult', 'Age Distribution', 'Aged', 'Cohort Studies', 'Comorbidity', 'Disease Susceptibility', 'Endometrial Neoplasms', 'Endometriosis', 'Female', 'Historically Controlled Study', 'Humans', 'Middle Aged', 'Neoplasms', 'Ovarian Neoplasms', 'Risk Factors', 'Taiwan', 'Thyroid Neoplasms'] | 29,522,577 | [['C13.351.500.852.113'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['C23.550.291.687', 'G07.100.250'], ['C04.588.945.418.948.585', 'C13.351.500.852.7... | ['Diseases [C]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of the alpha-1 adrenoceptor blocker on tissue norepinephrine contents in human benign prostatic hyperplasia. | To see the effect of the alpha-adrenergic blocking agent on tissue norepinephrine contents of the prostate, norepinephrine (NE) levels were investigated in patients with symptomatic benign prostatic hyperplasia (BPH). Morphometrical analyses were also performed to detect the differences in tissue composition. Nineteen ... | ['Adrenergic alpha-1 Receptor Antagonists', 'Adrenergic alpha-Agonists', 'Adrenergic alpha-Antagonists', 'Aged', 'Chromatography, High Pressure Liquid', 'Humans', 'Male', 'Muscle, Smooth', 'Norepinephrine', 'Prostate', 'Prostatic Hyperplasia', 'Sulfonamides', 'Tamsulosin'] | 9,241,547 | [['D27.505.519.625.050.200.100.100', 'D27.505.696.577.050.200.100.100'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['M01.060.116.100'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.570', 'A10.690... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vesicles in haptotaxis with hydrodynamical dissipation. | We analyze the problem of vesicle migration in haptotaxis (a motion directed by an adhesion gradient), though most of the reasoning applies to chemotaxis as well as to a variety of driving forces. A brief account has been published on this topic. We present an extensive analysis of this problem and provide a basic disc... | ['Adsorption', 'Chemotaxis', 'Computer Simulation', 'Elasticity', 'Energy Transfer', 'Liposomes', 'Membrane Fluidity', 'Membranes, Artificial', 'Models, Chemical', 'Molecular Conformation', 'Motion', 'Particle Size', 'Rheology', 'Shear Strength'] | 15,011,072 | [['G01.030', 'G02.020'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['L01.224.160'], ['G01.374.590'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['G01.154.500', 'G0... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Functional reconstruction with an extended supraclavicular fasciocutaneous island flap following ablation of advanced oropharyngeal cancer. | The aim of the present study was to evaluate the functional outcome of an extended supraclavicular fasciocutaneous island flap for reconstructing oropharyngeal defects.The 15 patients with oropharyngeal cancers ranged in age from 54 to 73 years. Primary tumor excisions via a transmandibular approach and neck dissection... | ['Aged', 'Fascia', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neck Dissection', 'Neoplasm Staging', 'Oropharyngeal Neoplasms', 'Reconstructive Surgical Procedures', 'Recovery of Function', 'Skin Transplantation', 'Surgical Flaps', 'Treatment Outcome'] | 23,147,314 | [['M01.060.116.100'], ['A02.340', 'A10.165.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.446.318', 'E04.580.411'], ['E01.789.625'], ['C04.588.443.665.710.684', 'C07.550.745.671', 'C09.647.710.685', 'C09.775.549.685'], ['E04.680'], ['G16.757'], ['E02.095.147.725.700', 'E04.680.275.85... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Total laparoscopic hysterectomy with earlier uterine artery ligation. | We compared the feasibility, blood loss, duration of surgery, and complications between patients in whom both uterine arteries were sutured at the beginning of total laparoscopic hysterectomy (TLH) and patients in whom suturing was done after cornual pedicles. Using a prospective study (Canadian Task Force classificati... | ['Adult', 'Aged', 'Arteries', 'Blood Loss, Surgical', 'Female', 'Humans', 'Hysterectomy', 'Laparoscopy', 'Ligation', 'Middle Aged', 'Uterus'] | 18,439,511 | [['M01.060.116'], ['M01.060.116.100'], ['A07.015.114'], ['C23.550.414.300', 'C23.550.505.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E04.426'], ['M01.060.116.630'], ['A05.360.319.679']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lactoperoxidase activity in milk is correlated with somatic cell count in dairy cows. | Lactoperoxidase (LPO) is a milk protein with antimicrobial function. The present study was undertaken to examine the correlation between LPO activity and somatic cell count (SCC) in milk to use LPO activity as an indicator of mastitis. Composite milk of 36 cows and quarter milk of 3 cows were collected once per week fr... | ['Animals', 'Cattle', 'Cell Count', 'Female', 'Lactoperoxidase', 'Milk', 'Parity'] | 21,787,923 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D08.811.682.732.550'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['G08.686.677', 'G08.686.784.769.472', 'N06.850.490.812.600']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. | Using a two-step screening system for genes involved in tissue invasion [Kataoka et al., Cancer Lett. 163(2) (2001) 213], we identified a cDNA whose expression level was higher in mouse placenta at later stages of gestation and in sublines of cancer cells with low degrees of invasiveness. The deduced amino acid sequenc... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blotting, Northern', 'Cell Movement', 'DNA, Complementary', 'Gastric Mucosa', 'Intestine, Small', 'Kidney', 'Lung', 'Mice', 'Molecular Sequence Data', 'N-Acetylglucosaminyltransferases', 'Neoplasm Invasiveness', 'Neoplasms', 'Phylogeny', 'RNA, Messenger', 'Sequence H... | 12,061,784 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['G04.198', 'G07.568.500.180'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['A03.556.875.875.440', 'A10.615.550.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Zika virus : a review]. | Since early 2015, the Zika virus epidemic has spread rapidly through South America and the Caribbean and the first cases of local transmission have just been reported in Florida. Maternal infection during pregnancy can cause serious birth defects. Pregnant women and their partners should avoid travelling to areas of Zi... | ['Congenital Abnormalities', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Travel', 'Zika Virus Infection'] | 28,692,228 | [['C16.131'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C01.674', 'C13.703.700'], ['I03.883'], ['C01.920.500.990', 'C01.925.081.990', 'C01.925.782.350.250.990']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Newborn care practices in Pemba Island (Tanzania) and their implications for newborn health and survival. | Newborn mortality accounts for about one-third of deaths in children under five. Neglecting this problem may undermine the fourth Millennium Development Goal of reducing child mortality by two-thirds by 2015. This study was conducted in Tanzania, where an estimated 32/1000 infants die within the first 28 days. Our obje... | ['Adolescent', 'Adult', 'Attitude to Health', 'Breast Feeding', 'Cultural Characteristics', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant Care', 'Infant Mortality', 'Infant, Newborn', 'Male', 'Mothers', 'Tanzania'] | 18,582,353 | [['M01.060.057'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.088.120'], ['E05... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Only for "purely scientific" institutions: the Medical Library Association's Exchange, 1898-1950s. | OBJECTIVE: Centralized exchanges of scientific materials existed by the late nineteenth century, but they did not include medical publications. North American medical leaders therefore formed an association of institutions to run their own exchange: the Medical Library Association (MLA). After providing background to t... | ['American Medical Association', 'Drug Industry', 'History, 19th Century', 'History, 20th Century', 'Libraries, Medical', 'Societies', 'United States'] | 21,464,849 | [['N03.540.828.589.274'], ['J01.576.655.750'], ['K01.400.504.937'], ['K01.400.504.968'], ['J03.400.596.831.937', 'L01.346.596.719.875'], ['N03.540.828'], ['Z01.107.567.875']] | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Effect of finish line on marginal fit of sintered gold copings. | The aim of this study was to evaluate the vertical marginal gap of sintered gold copings and metal-ceramic crowns with different finish line preparations: a beveled round shoulder (BRS) and a beveled long chamfer (BLC), testing the null hypotheses that there are no differences in marginal gap regardless of finish line ... | ['Crowns', 'Dental Materials', 'Dental Prosthesis Design', 'Gold'] | 24,173,248 | [['E06.780.346.250', 'E07.695.190.088'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['E06.780.346.625', 'E06.912.145'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Detection of viruses in water of the Baltic Sea (author's transl)]. | Virological examination of water of the Baltic Sea in the neighbourhood of a sewage outfall was done. By means of an apparatus for concentrating viruses in water, it was possible to detect enteroviruses in four of eleven samples, and in general in those moments, when conditions were fulfilled by a certain windway. The ... | ['Enterovirus', 'Escherichia coli', 'Germany, West', 'Seawater', 'Sewage', 'Water Microbiology', 'Water Pollution'] | 199,000 | [['B04.820.578.750.284'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['Z01.586.350'], ['G16.500.275.725.500'], ['D20.944.932.500'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['N06.850.460.790']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel. | BACKGROUND: There is a need for drug delivery systems (DDS) that can enhance cytosolic delivery of anti-cancer drugs trapped in the endo-lysosomal compartments. Exposure of cells to specific photosensitizers followed by light exposure (photochemical internalization, PCI) results in transfer of agents from the endocytic... | ['Animals', 'Antineoplastic Agents', 'Cell Line, Tumor', 'Drug Delivery Systems', 'Female', 'Humans', 'Immunoglobulin Fragments', 'Immunotoxins', 'Mice', 'Mice, Inbred BALB C', 'Photochemistry', 'Recombinant Fusion Proteins'] | 19,690,617 | [['B01.050'], ['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541.500', 'D12.776.124.486.485.680', 'D12.776.124.790.651.680', 'D12.776.377.715.548.680'], ['D12.776.124.790.651.114.580.450', 'D12.776.377.715.548.114.580.450', 'D27.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of viral capsid elastic properties from equilibrium thermal fluctuations. | We apply two-dimensional elasticity theory to viral capsids to develop a framework for calculating elastic properties of viruses from equilibrium thermal fluctuations of the capsid surface in molecular dynamics and elastic network model trajectories. We show that the magnitudes of the long wavelength modes of motion av... | ['Algorithms', 'Capsid', 'Capsid Proteins', 'Computer Simulation', 'Elasticity', 'Molecular Dynamics Simulation', 'Motion', 'Temperature', 'Viruses'] | 21,635,128 | [['G17.035', 'L01.224.050'], ['A21.249.500.250'], ['D12.776.964.970.600.550'], ['L01.224.160'], ['G01.374.590'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G01.482'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['B04']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Acute effects of endothelins on endogenous adrenomedullin system in the rat heart: Immunocytochemical and autoradiographic studies. | Many lines of evidence indicate that adrenomedullin (AM) through its coronary vasodilatory and inotropic effects, exerts a major cardiac protective action. Conversely, endothelins (ETs) exert a cardiac detrimental action, which seems to be mainly mediated by the ETA receptor, whose activation promotes coronary constric... | ['Adrenomedullin', 'Animals', 'Autoradiography', 'Coronary Vessels', 'Endothelins', 'Heart', 'Immunohistochemistry', 'Male', 'Myocardium', 'Peptides', 'Rats', 'Rats, Sprague-Dawley'] | 15,067,368 | [['D06.472.699.077', 'D12.644.548.017'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A07.015.114.269', 'A07.015.908.194'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['A07.541'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Fellow eye comparison of corneal thickness and curvature in descemet membrane endothelial keratoplasty and descemet stripping automated endothelial keratoplasty. | PURPOSE: To compare posterior corneal curvature in the fellow eye of the same patients after Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK).METHODS: This retrospective, case series comparative study included consecutive patients who underwent DSAEK in... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cornea', 'Descemet Membrane', 'Descemet Stripping Endothelial Keratoplasty', 'Endothelium, Corneal', 'Female', "Fuchs' Endothelial Dystrophy", 'Humans', 'Male', 'Middle Aged', 'Organ Preservation', 'Organ Size', 'Retrospective Studies', 'Tissue Donors', 'Visual Acuity'] | 24,699,562 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A09.371.060.217'], ['A09.371.060.217.271', 'A10.615.179.437'], ['E02.095.147.725.262', 'E04.540.825.374.112', 'E04.936.580.262'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['C11.204.236.438', 'C11.270.162.438', 'C16.320.290.162.4... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bender scores and the horse as a distinct item on object assembly of the WISC. | This exploratory study investigated the relationship between two measures of perceptual-motor problems. Ratios derived from the Object Assembly subtest of the WISC with errors greater than 1 SD on the Bender test using Koppitz' scoring system were compared. The sample of 66 white middle-class children was 6 to 11 yr. o... | ['Bender-Gestalt Test', 'Brain Damage, Chronic', 'Child', 'Female', 'Humans', 'Learning Disabilities', 'Male', 'Neurocognitive Disorders', 'Psychomotor Performance', 'Wechsler Scales'] | 6,493,922 | [['F04.711.513.180', 'F04.711.647.138'], ['C10.228.140.140'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.150.550', 'C23.888.592.604.150.550', 'F03.625.562'], ['F03.615'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['F04.711.141.493.822']] | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data. | Large-scale untargeted lipidomics experiments involve the measurement of hundreds to thousands of samples. Such data sets are usually acquired on one instrument over days or weeks of analysis time. Such extensive data acquisition processes introduce a variety of systematic errors, including batch differences, longitudi... | ['Datasets as Topic', 'Lipidomics', 'Quality Control', 'Scientific Experimental Error'] | 30,758,187 | [['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['H01.158.201.586.500', 'H01.158.273.180.599.500', 'H01.181.122.638.500'], ['J01.897.608'], ['E05.318.370.725.250.500', 'N05.715.360.300.202.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase. | The enzymatic dephosphorylation of the magnetic resonance imaging contrast agent Teslascan was studied in in vitro experiments with acid phosphatase (prostatic, from human semen) and alkaline phosphatase (from human placenta). The active component, MnDPDP (manganese (II)-N,N'-dipyridoxylethylenediamine-N,N'-diacetate-5... | ['Acid Phosphatase', 'Alkaline Phosphatase', 'Contrast Media', 'Edetic Acid', 'Phosphorylation', 'Pyridoxal Phosphate'] | 11,377,042 | [['D08.811.277.352.650.025'], ['D08.811.277.352.650.035'], ['D27.505.259.500', 'D27.720.259'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D03.383.725.676.925.500.500', 'D08.211.740']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Choice of level in lower extremity amputation--nationwide survey. | This survey analyses the levels of all major lower limb amputations in Denmark performed in 1980. During that year a total of 2,404 amputations were carried out on 2,177 patients. | ['Adult', 'Aged', 'Amputation', 'Denmark', 'Diabetes Mellitus', 'Female', 'Humans', 'Knee', 'Leg', 'Male', 'Middle Aged', 'Venous Insufficiency'] | 6,622,232 | [['M01.060.116'], ['M01.060.116.100'], ['E04.555.080'], ['Z01.542.816.124'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.450'], ['A01.378.610.500'], ['M01.060.116.630'], ['C14.907.952']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Familial osteosclerosis with abnormalities of the nervous system and meninges. | A mother and daughter with osteosclerotic dysplasia are described. The daughter had generalized osteosclerosis, flattening of the angles of the mandibles, high-arched palate, mandibular and facial bone hypoplasia, a large sella turcica, and spacious foramen magnum, platybasia, basilar impression, widened spinal cord wi... | ['Abnormalities, Multiple', 'Adolescent', 'Bone and Bones', 'Diagnosis, Differential', 'Female', 'Humans', 'Mandibulofacial Dysostosis', 'Meninges', 'Nervous System Malformations', 'Osteosclerosis', 'Syndrome'] | 830,893 | [['C16.131.077'], ['M01.060.057'], ['A02.835.232', 'A10.165.265'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.099.370.231.576', 'C05.660.207.231.576', 'C11.270.147.750', 'C16.131.621.207.231.576'], ['A08.186.566'], ['C10.500', 'C16.131.666'], ['C05.116.099.708.702'], ['C23.550.288.500']] | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A randomized open-label study of gabapentin and lamotrigine in adults with learning disability and resistant epilepsy. | The aim of this study was to evaluate the efficacy and safety of gabapentin in patients with learning disabilities and resistant epilepsy, comparing the effects of gabapentin with lamotrigine on efficacy, behaviour and mood. An open-label, randomized, parallel group, multicentre add-on study comparing gabapentin with l... | ['Acetates', 'Adolescent', 'Adult', 'Amines', 'Anticonvulsants', 'Cyclohexanecarboxylic Acids', 'Drug Administration Schedule', 'Epilepsy', 'Female', 'Gabapentin', 'Humans', 'Intellectual Disability', 'Lamotrigine', 'Male', 'Middle Aged', 'Severity of Illness Index', 'Treatment Outcome', 'Triazines', 'gamma-Aminobutyri... | 11,407,953 | [['D02.241.081.018', 'D10.251.400.045'], ['M01.060.057'], ['M01.060.116'], ['D02.092'], ['D27.505.954.427.080'], ['D02.241.223.268', 'D02.455.426.392.368.367.218'], ['E02.319.283'], ['C10.228.140.490'], ['D02.092.521', 'D02.241.081.114.500.350.300', 'D02.241.223.268.469', 'D02.455.426.392.368.367.218.500', 'D12.125.190... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Removal of atrazine, lindane and diazinone from water by organo-zeolites. | Systematic adsorption tests were carried out to determine the efficiency of organo-zeolite (OZ) for removal of atrazine, lindane and diazinone from water. The hydrophobic character of OZ-pesticide interactions was confirmed by measuring the amount of pesticides sorbed on zeolite samples modified with 25, 50, 75 and 150... | ['Adsorption', 'Atrazine', 'Diazinon', 'Herbicides', 'Hexachlorocyclohexane', 'Insecticides', 'Molecular Structure', 'Water Purification', 'Zeolites'] | 16,460,782 | [['G01.030', 'G02.020'], ['D03.383.931.247'], ['D02.705.400.625.200', 'D02.705.539.345.200', 'D02.886.300.692.200'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D02.455.526.439.600'], ['D27.720.031.700.491', 'D27.888.723.491'], ['G02.111.570', 'G02.466'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Specific association of the gene product of PKD2 with the TRPC1 channel. | The function(s) of the genes (PKD1 and PKD2) responsible for the majority of cases of autosomal dominant polycystic kidney disease is unknown. While PKD1 encodes a large integral membrane protein containing several structural motifs found in known proteins involved in cell-cell or cell-matrix interactions, PKD2 has hom... | ['Amino Acid Sequence', 'Binding Sites', 'Calcium Channels', 'Cell Line', 'Humans', 'Ion Channels', 'Kidney', 'Membrane Proteins', 'Molecular Sequence Data', 'Polycystic Kidney, Autosomal Dominant', 'Proteins', 'Recombinant Fusion Proteins', 'Recombinant Proteins', 'Sequence Alignment', 'Sequence Homology, Amino Acid',... | 10,097,141 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['A05.810.453'], ['D12.776.543'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High symptom reporters are less interoceptively accurate in a symptom-related context. | OBJECTIVE: We investigated the role of a symptom interpretation frame on the accuracy of interoception and on retrospective symptom reporting in nonclinical high and low reporters of medically unexplained symptoms.METHODS: All participants (N=74) went through two subsequent trials of the Rebreathing Test, inducing alte... | ['Adolescent', 'Adult', 'Affect', 'Attention', 'Carbon Dioxide', 'Cues', 'Culture', 'Female', 'Humans', 'Hypercapnia', 'Illness Behavior', 'Lung Volume Measurements', 'Male', 'Mental Recall', 'Personality Inventory', 'Respiration', 'Sensation', 'Somatoform Disorders', 'Young Adult'] | 18,940,371 | [['M01.060.057'], ['M01.060.116'], ['F01.470.047'], ['F02.830.104.214'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['F02.463.425.234'], ['I01.076.201.450', 'I01.880.853.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.544'], ['F01.145.499'], ['E01.370.386.700.485'], ['F02.463.425.540.641']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. | The ecdysteroid hormones coordinate the major stages of insect development, notably moulting and metamorphosis, by binding to the ecdysone receptor (EcR); a ligand-inducible nuclear transcription factor. To bind either ligand or DNA, EcR must form a heterodimer with ultraspiracle (USP), the homologue of retinoid-X rece... | ['Animals', 'Binding Sites', 'Crystallography, X-Ray', 'Dimerization', 'Dioxanes', 'Ecdysterone', 'Humans', 'Hydrazines', 'Ligands', 'Models, Molecular', 'Moths', 'Protein Conformation', 'Receptors, Steroid'] | 14,595,375 | [['B01.050'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['G02.206', 'G03.230'], ['D03.383.188'], ['D04.210.500.247.222.265.165.750', 'D06.472.445.573.271.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442'], ['D27.720.470.480'], ['E05.599.595'], ['B01.050.500.131.617.720.500.500.937.650'], ['G02.111.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Helicobacter pylori in dental plaque and gastric mucosa. | OBJECTIVE: The aim of this study was to investigate the presence of Helicobacter pylori in both dental plaque and gastric mucus.STUDY DESIGN: Dental scaling hand instruments were used to collect supragingival and subgingival dental plaque from 81 dentate participants. Denture plaque was obtained from the fitting surfac... | ['Aged', 'Aged, 80 and over', 'Dental Plaque', 'Gastric Mucosa', 'Helicobacter pylori', 'Humans', 'Mouth, Edentulous'] | 8,705,587 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C07.793.208.377'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.465.550', 'C07.793.597']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Altered sensitivity to excitotoxic cell death and glutamate receptor expression between two commonly studied mouse strains. | Alterations in glutamatergic synapse function have been implicated in the pathogenesis of many different neurological disorders, including ischemia, epilepsy, Parkinson's disease, Alzheimer's disease, and Huntington's disease. While studying glutamate receptor function in juvenile Batten disease on the C57BL/6J and 129... | ['Alanine', 'Animals', 'Animals, Newborn', 'Cell Death', 'Cell Survival', 'Cells, Cultured', 'Cerebellar Cortex', 'Dose-Response Relationship, Drug', 'Drug Resistance', 'Excitatory Amino Acid Agonists', 'Male', 'Mice', 'Mice, Inbred C57BL', 'N-Methylaspartate', 'Nerve Degeneration', 'Neurotoxins', 'Organ Culture Techni... | 20,544,821 | [['D12.125.042'], ['B01.050'], ['B01.050.050.282'], ['G04.146'], ['G04.346'], ['A11.251'], ['A08.186.211.132.810.428.200.212'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.984'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Properties of a modified cross-linked silicone for maxillofacial prostheses. | A dimethyl siloxane-triacetoxy terminated silane, Type A adhesive, can be modified with the base component of a medium grade polydimethyl siloxane with vinyl groups, MDX 4-4210, to produce more pliable maxillofacial prostheses. The mechanical properties of samples with various Type A adhesive/MDX 4-4210 ratios were det... | ['Adhesiveness', 'Adhesives', 'Biomechanical Phenomena', 'Dimethylpolysiloxanes', 'Hardness Tests', 'Materials Testing', 'Maxillofacial Prosthesis', 'Prosthesis Design', 'Silanes', 'Silicon', 'Silicone Elastomers', 'Silicones', 'Siloxanes', 'Surface Properties', 'Tensile Strength'] | 3,481,399 | [['G02.860.139'], ['D27.720.013', 'J01.637.016'], ['G01.154.090', 'G01.374.089'], ['D02.756.650.700.150', 'D05.750.900.850.150', 'D25.720.900.850.150', 'J01.637.051.720.900.850.150'], ['E05.417', 'E05.570.500.500', 'G01.374.647.457', 'G01.374.687.500'], ['E05.570'], ['E07.695.510'], ['E05.320.550', 'E07.695.680'], ['D0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Fracture experience of patients with coeliac disease: a population based survey. | BACKGROUND: While coeliac disease is now recognised as being associated with both osteoporosis and osteomalacia, the size of any increase in the risk of fracture in patients with coeliac disease compared with the general population has not been quantified.AIM: To examine the fracture experience of adults with coeliac d... | ['Adult', 'Age Distribution', 'Aged', 'Case-Control Studies', 'Celiac Disease', 'Female', 'Fractures, Bone', 'Health Surveys', 'Humans', 'Male', 'Middle Aged', 'Odds Ratio', 'Osteoporosis', 'Registries', 'Risk Assessment', 'Smoking'] | 12,631,662 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.405.469.637.250', 'C18.452.603.250'], ['C26.404'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.1... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Stretching position can affect levator scapular muscle activity, length, and cervical range of motion in people with a shortened levator scapulae. | OBJECTIVES: Levator scapulae (LS) muscle stretching exercises are a common method of lengthening a shortened muscle; however, the appropriate stretching position for lengthening the LS in people with a shortened LS remains unclear. The purpose of this study was to compare the effects of different stretching exercise po... | ['Electromyography', 'Female', 'Humans', 'Male', 'Muscle Stretching Exercises', 'Neck', 'Posture', 'Prone Position', 'Range of Motion, Articular', 'Superficial Back Muscles', 'Young Adult'] | 28,578,252 | [['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500.387.750', 'E02.779.483.750', 'E02.831.535.483.750', 'G11.427.410.698.277.249', 'I03.350.249'], ['A01.598'], ['G11.427.695'], ['G11.427.695.525'], ['E01.370.600.700', 'G11.427.760'], ['A02.633.567.175.875'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Multicenter validation of a simplified score to predict massive transfusion in trauma. | BACKGROUND: Several studies have described predictive models to identify trauma patients who require massive transfusion (MT). Early identification of lethal exsanguination may improve survival in this patient population. The purpose of the current study was to validate a simplified score to predict MT at multiple Leve... | ['Adult', 'Blood Transfusion', 'Female', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'ROC Curve', 'Retrospective Studies', 'Risk Assessment', 'Trauma Centers', 'Trauma Severity Indices', 'Triage', 'Wounds and Injuries', 'Young Adult'] | 20,622,617 | [['M01.060.116'], ['E02.095.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['E05.318.372.500.500.500', 'E05.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cimetidine in duodenal ulcer. Controlled trial. | As part of a double-blind controlled clinical trial of cimetidine (1.6 g daily) in patients with endoscopically proven duodenal ulcer, repeat endoscopy has been carried out in 24 patients after two and/or six weeks' treatment. At six weeks, 9 out of 11 patients on cimetidine and 3 out of 12 patients on placebo had heal... | ['Cimetidine', 'Clinical Trials as Topic', 'Double-Blind Method', 'Duodenal Ulcer', 'Guanidines', 'Humans', 'Placebos', 'Time Factors', 'Wound Healing'] | 73,797 | [['D02.078.370.200', 'D03.383.129.308.130'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['D02.078.370'], ['B01.050.150.900.649.313.988.400.112.400... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype. | BACKGROUND: The neuropathological changes of Alzheimer's disease occur universally in individuals with Down's syndrome as they reach middle age and worsen with increasing age. Thus, evaluation of patients of various ages with Down's syndrome allows one to construct a life history of the development of neuropathological... | ['Adolescent', 'Adult', 'Aging', 'Alzheimer Disease', 'Apolipoprotein E4', 'Apolipoproteins E', 'Child', 'Child, Preschool', 'Dementia', 'Down Syndrome', 'Female', 'Genotype', 'Hippocampus', 'Humans', 'Male', 'Middle Aged', 'Neurofibrillary Tangles'] | 7,710,373 | [['M01.060.057'], ['M01.060.116'], ['G07.345.124'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.380', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Semiautomated Surveillance of Deep Surgical Site Infections After Primary Total Hip or Knee Arthroplasty. | Manual surveillance of surgical site infections (SSIs) after total hip or knee arthroplasty is time-consuming and prone to error. Semiautomated surveillance based on routine care data extracted from electronic health records can retrospectively identify deep SSIs and substantially reduce workload while maintaining 100%... | ['Aged', 'Arthroplasty, Replacement, Hip', 'Arthroplasty, Replacement, Knee', 'Electronic Health Records', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Theoretical', 'Population Surveillance', 'Predictive Value of Tests', 'Retrospective Studies', 'Risk Assessment', 'Surgical Wound Infection'] | 28,366,180 | [['M01.060.116.100'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Using malpractice claims to identify risk factors for neurological impairment among infants following non-reassuring fetal heart rate patterns during labour. | RATIONALE, AIMS AND OBJECTIVES: We sought to use a novel case-selection methodology to identify antenatal or intrapartum risk factors associated with neonatal neurological impairment following non-reassuring fetal heart rate patterns during labour.METHOD: We used a retrospective case-control design with bivariate and m... | ['Adolescent', 'Adult', 'Female', 'Fetal Monitoring', 'Heart Rate, Fetal', 'Humans', 'Infant, Newborn', 'Insurance Claim Review', 'Malpractice', 'Massachusetts', 'Nervous System Diseases', 'Pregnancy', 'Pregnancy Complications', 'Retrospective Studies', 'Risk Factors', 'Young Adult'] | 20,482,746 | [['M01.060.057'], ['M01.060.116'], ['E01.370.378.230', 'E01.370.520.230'], ['G09.330.380.500.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N03.219.521.576.215'], ['I01.880.604.583.524', 'N03.706.535.606'], ['Z01.107.567.875.550.510'], ['C10'], ['G08.686.784.769'], ['C13.703'], ['E05.318... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Preparation and X-ray crystallographic analysis of recombinant obelin crystals diffracting to beyond 1.1 A. | Crystals of recombinant obelin, the Ca(2+)-regulated photoprotein from the marine hydroid Obelia longissima, have been grown from a solution containing PEG 8000 and potassium phosphate. Hexaminecobalt trichloride was used as an additive to increase the chance of crystallization. The crystals grow in a light yellow cubi... | ['Animals', 'Cnidaria', 'Crystallization', 'Crystallography, X-Ray', 'Luminescent Proteins', 'Protein Conformation', 'Recombinant Proteins'] | 11,717,517 | [['B01.050'], ['B01.050.500.308'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D12.776.532'], ['G02.111.570.820.709'], ['D12.776.828']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multispectral real-time fluorescence imaging for intraoperative detection of the sentinel lymph node in gynecologic oncology. | The prognosis in virtually all solid tumors depends on the presence or absence of lymph node metastases. Surgical treatment most often combines radical excision of the tumor with a full lymphadenectomy in the drainage area of the tumor. However, removal of lymph nodes is associated with increased morbidity due to infec... | ['Female', 'Fluorescent Dyes', 'Humans', 'Indocyanine Green', 'Lymph Nodes', 'Sentinel Lymph Node Biopsy', 'Spectrometry, Fluorescence', 'Uterine Cervical Neoplasms', 'Vulvar Neoplasms'] | 21,048,667 | [['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.400'], ['A10.549.400', 'A15.382.520.604.412'], ['E01.370.225.500.384.100.580', 'E01.370.225.998.054.580', 'E01.370.388.100.580', 'E04.074.580', 'E04.446.819', 'E05.200.500.384.100.580', 'E05.200.998.054.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Upper airway lesions in children after accidental ingestion of caustic substances. | Of 33 children admitted within 24 hours after accidental ingestion of a caustic substance, 14 (42.5%) had evidence of upper airway lesions on direct laryngoscopy. Three patients, 10 to 12 months old, needed endotracheal intubation for acute respiratory obstruction; four patients younger than 2 years had severe dyspnea ... | ['Ampicillin', 'Burns, Chemical', 'Caustics', 'Child', 'Child, Preschool', 'Epiglottis', 'Esophagoscopy', 'Fiber Optic Technology', 'Gastric Mucosa', 'Glottis', 'Humans', 'Infant', 'Intubation, Intratracheal', 'Laryngoscopy', 'Larynx', 'Prednisone', 'Radiography', 'Respiratory Insufficiency'] | 3,973,778 | [['D02.065.589.099.750.750.050', 'D02.886.108.750.750.050', 'D03.633.100.300.750.750.050'], ['C26.200.156'], ['D27.720.185', 'D27.888.569.185'], ['M01.060.406'], ['M01.060.406.448'], ['A02.165.257.625.411', 'A02.165.407.500.411', 'A04.329.591.411'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.24... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways. | Unlike other members of HSP70 family, GRP78 manifests multifaceted subcellular distribution and forms complex with different signals, resulting in its close correlation with various tumors. However, its expression profile and function in glioma remain less well defined. In this study, normal brain tissue and astrocytic... | ['Antibodies, Neutralizing', 'Astrocytoma', 'Brain Neoplasms', 'Cell Division', 'Chromones', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'Glioblastoma', 'Heat-Shock Proteins', 'Humans', 'Membrane Proteins', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Morpholin... | 21,112,319 | [['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Reduction of atherogenesis in an arterialized venous graft by using an external sleeve]. | The parietal thickening of a vein under hemodynamical conditions in the arterial system can be reduced when supporting the vein with a rigid external sleeve. To assess the role of thickness reduction in atherogenesis of an arterialized vein graft, a 4 mm thick external sleeve was implemented around the proximal half of... | ['Animals', 'Arteriosclerosis', 'Carotid Arteries', 'Clinical Protocols', 'Endothelium, Vascular', 'Hypercholesterolemia', 'Rabbits', 'Transplantation, Autologous', 'Veins'] | 1,345,700 | [['B01.050'], ['C14.907.137.126'], ['A07.015.114.186'], ['E02.183', 'N05.715.360.330.125'], ['A07.015.700.500', 'A10.272.491.355'], ['C18.452.584.500.500.396'], ['B01.050.150.900.649.313.968.700'], ['E04.936.664'], ['A07.015.908']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Copy Number Variations in Tilapia Genomes. | Discovering the nature and pattern of genome variation is fundamental in understanding phenotypic diversity among populations. Although several millions of single nucleotide polymorphisms (SNPs) have been discovered in tilapia, the genome-wide characterization of larger structural variants, such as copy number variatio... | ['Adaptation, Physiological', 'Animals', 'Chromosome Mapping', 'DNA Copy Number Variations', 'Gene Ontology', 'Genetics, Population', 'Genome', 'Genome-Wide Association Study', 'High-Throughput Nucleotide Sequencing', 'Molecular Sequence Annotation', 'Tilapia'] | 28,168,542 | [['G07.025', 'G16.012.500'], ['B01.050'], ['E05.393.183'], ['G05.365.795.297.500'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01.313.500.750.300.550.500.500', 'L01.453.245.945.079.500'], ['H01.158.273.343.335'], ['G05.360.340'], ['E05.318.370.392', 'E05.318.416.249', 'E05.3... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies. | AIM: To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors, in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand (TRAIL), on overcoming TRAIL resistance in hepatocellular carcinoma (HCC) and to study the efficacy of agonistic TRAIL antibodies, as... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Doxorubicin', 'Enzyme Inhibitors', 'Fluorouracil', 'Humans', 'Liver Neoplasms', 'Myeloid Cell Leukemia Sequence 1 Protein', 'Proto-Oncogene Proteins c-bcl-2', 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'TNF-Rela... | 20,014,456 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D27.505.519.389'], ['D03.383.742.698.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mapping of nuclease-sensitive sites in native reticulocyte ribosomes--an analysis of the accessibility of ribosomal RNA to enzymatic cleavage. | Treatment of ribosomes in reticulocyte lysates with low concentrations of the calcium-dependent nuclease from Staphylococcus aureus resulted in cleavage of rRNA. The positions of the cleaved phosphodiester bonds were localised by primer extension and polyacrylamide gel electrophoresis. S. aureus nuclease-induced strand... | ['Animals', 'Protein Biosynthesis', 'RNA, Ribosomal', 'Rabbits', 'Reticulocytes', 'Ribonucleases', 'Ribosomes', 'Staphylococcus aureus'] | 9,249,022 | [['B01.050'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D13.444.735.686'], ['B01.050.150.900.649.313.968.700'], ['A11.118.290.760', 'A11.148.790', 'A11.443.240.665', 'A15.145.229.334.760', 'A15.378.316.790'], ['D08.811.277.352.700'], ['A11.284.430.214.190.875.811'], ['B03.300.390.400.800.750.100', 'B03.353.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. | Previous work from our laboratory identified YggX as a protein whose accumulation increased the resistance of Salmonella enterica to superoxide stress, reversed defects attributed to oxidized [Fe-S] clusters, and decreased the spontaneous mutation frequency of the cells. Here we present work aimed at determining why th... | ['Bacterial Proteins', 'DNA Damage', 'DNA Glycosylases', 'Gene Expression Regulation, Bacterial', 'Hydroxyl Radical', 'In Vitro Techniques', 'Iron', 'Mutagenesis', 'N-Glycosyl Hydrolases', 'Salmonella enterica', 'Species Specificity'] | 12,670,952 | [['D12.776.097'], ['G05.200'], ['D08.811.074.249', 'D08.811.277.450.430.099'], ['G05.308.300'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['E05.481'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['G05.558'], ['D08.811.277.450.430'], ['B03.440.450.425.800.200', 'B03.660.250.150.71... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA). | The racemate and the enantiomers of 1-(3-methoxy-4-methyphenyl)-2- aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to substitute with high potency in 3,4-(methylenedioxy)methamphetamine (1) ... | ['3,4-Methylenedioxyamphetamine', 'Animals', 'Behavior, Animal', 'Brain', 'Chemical Phenomena', 'Chemistry', 'Dose-Response Relationship, Drug', 'Indans', 'Male', 'N-Methyl-3,4-methylenedioxyamphetamine', 'Phenethylamines', 'Rats', 'Rats, Inbred Strains', 'Serotonin Antagonists', 'Stereoisomerism', 'Structure-Activity ... | 1,674,539 | [['D02.092.471.683.152.660'], ['B01.050'], ['F01.145.113'], ['A08.186.211'], ['G02'], ['H01.181'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.426.559.847.486.487', 'D04.615.486.487'], ['D02.092.471.683.152.670'], ['D02.092.471.683'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Triplet chemotherapy for malignant pericardial mesothelioma: a case report. | Malignant pericardial mesothelioma (MPM) is a relatively rare neoplasm in Japan, and no standard treatment regimens have been established for this disease. A 47-year-old woman with MPM presenting with cardiac tamponade was treated using four cycles of chemotherapy consisting of cisplatin (CDDP) 40 mg/m2, gemcitabine (G... | ['Antineoplastic Combined Chemotherapy Protocols', 'Cisplatin', 'Deoxycytidine', 'Drainage', 'Drug Administration Schedule', 'Female', 'Heart Neoplasms', 'Humans', 'Mesothelioma', 'Middle Aged', 'Neutropenia', 'Pericardial Effusion', 'Remission Induction', 'Survivors', 'Vinblastine', 'Vinorelbine'] | 16,533,802 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['E02.309', 'E04.237'], ['E02.319.283'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.470.03... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression of serum survivin protein in diagnosis and prognosis of gallbladder cancer: a comparative study. | The role of survivin in gallbladder cancer (GBC) has not been evaluated. We investigated survivin protein expression in serum of patients with gallbladder diseases (cholelithiasis, n = 30; GBC, n = 39) and compared with healthy controls (n = 25). Clinicopathological parameters, diagnosis and prognosis of patients with ... | ['Adult', 'Biomarkers, Tumor', 'Case-Control Studies', 'Cholelithiasis', 'Female', 'Gallbladder Neoplasms', 'Humans', 'Inhibitor of Apoptosis Proteins', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Prognosis', 'ROC Curve', 'Survivin'] | 25,129,311 | [['M01.060.116'], ['D23.101.140'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.130.409'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.464.938.750.210', 'D12.644.360.075.437', 'D12.77... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model. | Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of hospitalization and often lead to severe infections and poor healing. It has been recently reported that patients with DFU have lower levels of antimicrobial peptides (AMPs) at the lesion area, which contributes with the impairment of wound... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antimicrobial Cationic Peptides', 'Biopsy', 'Case-Control Studies', 'Cathelicidins', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'Culture Media, Conditioned', 'Diabetic Foot', 'Female', 'Gene Expression Regulation', 'Humans', 'Keratinocytes', 'Male', 'Middle Aged', ... | 25,337,708 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.644.050', 'D12.776.543.695.054'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Wound healing in tadpole tailfin pieces in vitro. | Explants of tail fins from R. catesbeiana tadpoles undergo reepithelialization of their cut surfaces (healing) when cultured in vitro in Hanks' balanced salt solution at 22 degrees C. Healing is initiated early and closure of the wound is complete by 12 to 24 hours. Morphogenesis continues for several days as further r... | ['Animals', 'Anura', 'Culture Media', 'Culture Techniques', 'Larva', 'Rana catesbeiana', 'Skin Physiological Phenomena', 'Temperature', 'Wound Healing'] | 308,094 | [['B01.050'], ['B01.050.150.900.090.180'], ['D27.720.470.305', 'E07.206'], ['E05.481.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.150.900.090.180.708.180'], ['G13.750'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G16.762.891']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Use of a Vero cell-based fluorescent assay to assess relative toxicities of Shiga toxin 2 subtypes from Escherichia coli. | Shiga toxin-producing Escherichia coli is a leading cause of human gastroenteritis from food and waterborne sources worldwide. Shiga toxins 1 and 2 are important virulence factors linked to severe human illness. In particular, Shiga toxin 2 is composed of a diverse and heterogeneous group of subtypes with differential ... | ['Animals', 'Chlorocebus aethiops', 'Food Contamination', 'Green Fluorescent Proteins', 'Microscopy, Fluorescence', 'Shiga Toxin 1', 'Shiga Toxin 2', 'Shiga-Toxigenic Escherichia coli', 'Toxicity Tests', 'Vero Cells', 'Virulence Factors'] | 21,567,318 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['D12.776.532.265'], ['E01.370.350.515.458', 'E05.595.458'], ['D08.811.277.450.430.700.750.750.120', 'D12.776.097.275.877', 'D23.946.123.794.100', 'D23.946.330.575.120'], ['D... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Understanding the role of sex differences in work injuries: implications for primary care practice. | PURPOSE: Primary care physicians care for work-injured women and men, yet there is little information on sex differences in outcomes and factors contributing to post-injury outcomes to guide their evaluation and recommendations.METHODS: Two self-administered questionnaires were sent to a large sample of women and men w... | ['Accidents, Occupational', 'Adult', 'Age Factors', 'Cross-Sectional Studies', 'Data Collection', 'Female', 'Humans', 'Job Description', 'Male', 'Middle Aged', 'Multivariate Analysis', 'New Hampshire', 'Primary Health Care', 'Prognosis', 'Sex Factors', 'Socioeconomic Factors', 'Wounds and Injuries'] | 17,852,283 | [['N06.850.135.240'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.677.410'], ['M01.060.116.630'], [... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Using connected objects in clinical research. | Connected objects (CO), whether medical devices or not, are used in clinical research for data collection, a specific activity (communication, diagnosis, effector, etc.), or several functions combined. Their validation should be based on three approaches: technical and clinical reliability, data protection and cybersec... | ['Biomedical Research', 'Computer Communication Networks', 'Computer Security', 'Data Collection', 'Europe', 'Humans', 'Telemetry'] | 29,478,706 | [['H01.770.644.145'], ['L01.224.230.110'], ['L01.224.134', 'N04.452.910.200'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520.750', 'E05.925', 'L01.178.847.675']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
The dependency of bioactive follicle-stimulating hormone secretion on gonadotropin-releasing hormone in hypogonadal and cycling women. | An antagonist analog of GnRH, (Ac-delta 3-Pro1,p-F-D-Phe2,D-Trp3,6)GnRH (4F-antagonist), was administered to normal women and women with hypergonadotropic hypogonadism. Serum FSH levels were determined by both the granulosa cell aromatase bioassay and RIA. The constant infusion of 4F-antagonist (30 micrograms/kg.h) to ... | ['Adult', 'Biological Assay', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Follicular Phase', 'Gonadotropin-Releasing Hormone', 'Humans', 'Hypogonadism', 'Menstrual Cycle', 'Middle Aged', 'Radioimmunoassay'] | 3,123,512 | [['M01.060.116'], ['E05.091'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['G08.686.605.310'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isoelectric focusing of phosphorylated cattle rhodopsin. | 32P-rhodopsin was partially separated by isoelectric focusing into several fractions of different phosphorylation extent. It was found that the incorporated phosphate is not uniformly distributed in a population of rhodopsin molecules. In a preparation with an average phosphorylation extent of 2.4 moles of phosphate pe... | ['Animals', 'Cattle', 'Isoelectric Focusing', 'Phosphates', 'Photoreceptor Cells', 'Protein Binding', 'Retinal Pigments', 'Rhodopsin'] | 890,058 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.401.663', 'E05.301.300.663'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625', 'A11.671.650.850.625', 'A11.671.650.915.937'], ['G02.111.679'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acquired slow-channel syndrome. | We report the case of a 37-year-old man with clinical and electrophysiological features of hereditary slow-channel syndrome (SCS) and antibodies against acetylcholine receptors (AChR-Abs). He presented with weakness of shoulder and hand muscles. A supramaximal single stimulus to the motor nerves disclosed a double comp... | ['Adult', 'Humans', 'Male', 'Muscles', 'Myasthenic Syndromes, Congenital', 'Neural Conduction'] | 11,003,795 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633', 'A10.690'], ['C10.668.758.800', 'C16.320.590'], ['G07.265.753', 'G11.561.601']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacokinetics and pharmacodynamics of slow-release theophylline during treatment with nimesulide. | The pharmacodynamic and pharmacokinetic interactions were studied between nimesulide, a recently introduced non-steroidal anti-inflammatory drug, and theophylline, another highly protein-bound drug, in patients who were receiving slow-release theophylline for a chronic airflow-obstruction and who also needed anti-infla... | ['Adolescent', 'Adult', 'Aged', 'Delayed-Action Preparations', 'Drug Interactions', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sulfonamides', 'Theophylline'] | 1,814,842 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D26.255.210', 'E02.319.300.253'], ['G07.690.773.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.065.884', 'D02.886.590.700'], ['D03.132.960.751', 'D03.633.100.759.758.824.751']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART. | Background: Cytopenia is a frequent hematological disorder in patients with human immunodeficiency virus (HIV) infection. However, the distribution and risk factors of cytopenia in patients starting highly active anti-retrovirus treatment (HAART) and the effect of HAART on cytopenia were not fully investigated.Methods:... | ['Adult', 'Antiretroviral Therapy, Highly Active', 'Female', 'HIV Infections', 'Hematologic Diseases', 'Humans', 'Logistic Models', 'Male', 'Prevalence', 'Risk Factors'] | 32,090,076 | [['M01.060.116'], ['E02.319.310.075'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C15.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Beta-cell expression of 65-kDa heat-shock protein mRNA is function- and age-dependent. | This study examined the expression of mRNA coding for the 65-kDa heat-shock protein (HSP) in rat islet cells of different functional states and different ages. In addition, beta cells and non-beta cells purified by fluorescence-activated cell sorting were studied. Total RNA from islet cells and insulin-producing RINm5F... | ['Age Factors', 'Animals', 'Heat-Shock Proteins', 'Islets of Langerhans', 'Male', 'RNA, Messenger', 'Rats', 'Rats, Inbred Lew'] | 1,389,096 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['D12.776.580.216'], ['A03.734.414', 'A06.300.414'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.280', 'B01.050.150.900.649.313.992.635.505.700.400.280']] | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Overdentures on implants placed in bone augmented with fresh frozen bone. | AIM: In the last decade several studies have been performed to evaluate the clinical outcome of one or two stage loaded implants supporting overdentures. Since fresh frozen bone (FFB) has an ever-increasing number of clinical applications and few reports are available on implants inserted into FFB, we performed a retro... | ['Alveolar Ridge Augmentation', 'Bone Transplantation', 'Cryopreservation', 'Dental Implantation, Endosseous', 'Dental Implants, Single-Tooth', 'Denture, Overlay', 'Equipment Design', 'Female', 'Humans', 'Jaw, Edentulous', 'Jaw, Edentulous, Partially', 'Kaplan-Meier Estimate', 'Male', 'Mandible', 'Maxilla', 'Middle Age... | 21,252,845 | [['E04.545.550.100', 'E06.645.550.100'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
HIV/hepatitis coinfection in eastern Europe and new pan-European approaches to hepatitis prevention and management. | ISSUES: HIV/hepatitis coinfection in Europe; WHO European clinical protocols on the management of people coinfected with HIV/AIDS and hepatitis B or C (HBV or HCV); stakeholder recommendations for better HCV services.INTRODUCTION: The increasing availability of highly active antiretroviral therapy throughout Europe and... | ['Antiviral Agents', 'Europe, Eastern', 'HIV Infections', 'Harm Reduction', 'Health Knowledge, Attitudes, Practice', 'Health Policy', 'Health Services Accessibility', 'Hepatitis B', 'Hepatitis C', 'Humans', 'Needle-Exchange Programs', 'Patient Education as Topic', 'Practice Guidelines as Topic', 'Prevalence', 'Substanc... | 17,854,732 | [['D27.505.954.122.388'], ['Z01.542.248'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.145.477'], ['F01.100.150.500', 'N05.300.150.410'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['N04.590.374.350', '... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Movement sequencing abilities and basal ganglia morphology in first-episode schizophrenia. | INTRODUCTION: Studies of brain morphology suggest a link between movement sequencing ability and basal ganglia dysfunction. Unfortunately, relevant studies have provided inconsistent data, which may be the result of differences in the methods of brain morphology assessment, statistical analysis or heterogeneity of the ... | ['Acute Disease', 'Basal Ganglia', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Movement Disorders', 'Schizophrenia', 'Severity of Illness Index', 'Young Adult'] | 18,609,414 | [['C23.550.291.125'], ['A08.186.211.200.885.287.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C10.228.662'], ['F03.700.750'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['M01.060.116.815']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The association between red cell distribution width, erythropoietin levels, and coronary artery disease. | BACKGROUND: Red cell distribution width (RDW) is a cardiac marker for risk stratification and prognostic evaluation of coronary artery disease (CAD); however, the underlying mechanism remains unclear. Erythropoietin (EPO), a crucial factor affecting erythropoiesis, has been reported to be a protective molecule regulati... | ['Aged', 'Case-Control Studies', 'Coronary Angiography', 'Coronary Artery Disease', 'Cross-Sectional Studies', 'Erythrocyte Indices', 'Erythropoietin', 'Female', 'Humans', 'Linear Models', 'Logistic Models', 'Male', 'Middle Aged', 'Risk Factors'] | 28,885,393 | [['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['E05.318.372.500.875', 'N05.715.360.330.500.875',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Heat exchange between human body and environment (theoretical bases of physiological measurement and evaluation)]. | In the first part of this report the theory of the heat exchange between human body and external environment is developed. In particular, the problems concerning energy expenditure and heat production [metabolic heat] during physical activity, the heat exchange between internal organs and body surface, and its eliminat... | ['Body Temperature Regulation', 'Convection', 'Energy Metabolism', 'Hot Temperature', 'Humans', 'Lung', 'Models, Biological', 'Respiration', 'Stress, Physiological', 'Thermodynamics', 'Water Loss, Insensible'] | 10,771,731 | [['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['G01.906.230'], ['G03.295'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['E05.599.395'], ['G09.772.705'], ['G07... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Psychological Symptoms and Well-Being After Treatment for Primary Aldosteronism. | Primary aldosteronism (PA) is an increasingly identified cause of secondary hypertension. PA can be caused by an aldosterone-producing adenoma or by bilateral adrenal hyperplasia, generally treated by adrenalectomy or mineralocorticoid receptor antagonists, respectively. Recent studies suggest that PA is associated wit... | ['Adrenalectomy', 'Adult', 'Aged', 'Aldosterone', 'Cross-Sectional Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperaldosteronism', 'Male', 'Middle Aged'] | 29,895,075 | [['E04.270.115'], ['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy of different selective media for the isolation of salmonellae from faeces. | Comparative results obtained in isolating salmonellae from faeces by the use of tetrathionate broth, MS, and MM enrichment medium are given. The best results were obtained by tetrathionate broth prepared from infusion broth. The MS as well as the MM medium increased the total number of positive results. | ['Culture Media', 'In Vitro Techniques', 'Salmonella', 'Salmonella Infections'] | 5,844,202 | [['D27.720.470.305', 'E07.206'], ['E05.481'], ['B03.440.450.425.800', 'B03.660.250.150.710'], ['C01.150.252.400.310.821']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comprehensive study of ovine haemostasis to assess suitability to model human coagulation. | INTRODUCTION: Similarities in size, anatomy and physiology have supported the use of sheep to model a wide range of human diseases, including coagulopathy. However, coagulation studies involving sheep are limited by the absence of high quality data defining normal ovine coagulation and fibrinolysis.MATERIALS AND METHOD... | ['Animals', 'Blood Coagulation Tests', 'Female', 'Hemostasis', 'Humans', 'Male', 'Models, Animal', 'Sheep'] | 24,929,837 | [['B01.050'], ['E01.370.225.625.115', 'E05.200.625.115'], ['G09.188.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.598'], ['B01.050.150.900.649.313.500.380.791']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression and display of UreA of Helicobacter acinonychis on the surface of Bacillus subtilis spores. | BACKGROUND: The bacterial endospore (spore) has recently been proposed as a new surface display system. Antigens and enzymes have been successfully exposed on the surface layers of the Bacillus subtilis spore, but only in a few cases the efficiency of expression and the effective surface display and have been determine... | ['Bacillus subtilis', 'Bacterial Proteins', 'Gene Expression', 'Helicobacter', 'Recombinant Fusion Proteins', 'Spores, Bacterial', 'Urease'] | 20,082,702 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['G05.297'], ['B03.440.500', 'B03.660.150.235.500.250'], ['D12.776.828.300'], ['A11.870.700', 'B05.775.700'], ['D08.811.277.087.902']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maintenance Electroconvulsive Therapy in Severe Bipolar Disorder: A Retrospective Chart Review. | OBJECTIVE: The aim of this study was to evaluate the effectiveness of continuation and maintenance electroconvulsive therapy (C/M-ECT) in patients with bipolar or schizoaffective disorder.METHODS: We reviewed the charts of all patients diagnosed with a bipolar or schizoaffective disorder treated with C/M-ECT from Augus... | ['Adult', 'Aged', 'Anesthesia', 'Bipolar Disorder', 'Diagnostic and Statistical Manual of Mental Disorders', 'Electroconvulsive Therapy', 'Female', 'Hospitalization', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Psychotic Disorders', 'Retrospective Studies', 'Treatment Outcome'] | 26,172,058 | [['M01.060.116'], ['M01.060.116.100'], ['E03.155'], ['F03.084.500'], ['L01.453.245.945.200'], ['F04.570.200.583', 'F04.669.224.300'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['F03.700.675'], ['E05.318.372.500.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Tetralogy of fallot and absence of left pulmonary artery. | Unilateral absence of the pulmonary artery is a rare congenital lesion usually caused by backward displacement of the conical artery of the truncus arteriosus. The purpose of this report is to describe and discuss the treatment of an 8-year-old patient who presented with cyanosis and was diagnosed with tetralogy of Fal... | ['Abnormalities, Multiple', 'Cardiac Surgical Procedures', 'Child', 'Collateral Circulation', 'Cyanosis', 'Humans', 'Male', 'Pulmonary Artery', 'Radiography', 'Tetralogy of Fallot', 'Treatment Outcome', 'Vascular Surgical Procedures'] | 18,810,704 | [['C16.131.077'], ['E04.100.376', 'E04.928.220'], ['M01.060.406'], ['G09.330.100.248'], ['C23.888.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.715'], ['E01.370.350.700'], ['C14.240.400.849', 'C14.280.400.849', 'C16.131.240.400.849'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.8... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of antidiuretic activity in the inhibition of renin secretion by vasopressin in anesthetized dogs. | The nature of the activity of vasopressin which is responsible for the inhibition of renin secretion was studied by comparing the effects of vasopressin (AVP) and analogs of AVP in anesthetized water-loaded dogs. Infusion of AVP (1.0 ng/kg/min) increased mean arterial pressure (MAP) and decreased heart rate (HR) and fr... | ['Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Deamino Arginine Vasopressin', 'Diuresis', 'Dogs', 'Female', 'Heart Rate', 'Kinetics', 'Male', 'Natriuresis', 'Oxytocin', 'Renin', 'Time Factors'] | 3,520,511 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456.925.100.250', 'D12.644.548.691.692.781.100.250', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tuning the mechanism of DNA cleavage photosensitized by ruthenium dipyridophenazine complexes by varying the structure of the two non intercalating ligands. | The influence of the nature of ligands on the efficiency of ruthenium complexes for photosensitizing DNA cleavage was investigated. Ru(bipy)2dppz2+ and Ru(bpz)2dppz2+ were selected as DNA breakers on the basis of their high affinity for DNA due to the presence of a dppz ligand which can partially intercalate in the maj... | ['Bacteriophage phi X 174', 'DNA Damage', 'DNA, Superhelical', 'DNA, Viral', 'Intercalating Agents', 'Ligands', 'Light', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Organometallic Compounds', 'Phenazines', 'Photosensitizing Agents', 'Pyridines', 'Ruthenium', 'Structure-Activity Relationship'] | 7,815,190 | [['B04.123.205.320', 'B04.123.470.500.320', 'B04.280.470.500.320'], ['G05.200'], ['D13.444.308.283.250', 'G02.111.570.820.486.212.250', 'G05.360.580.156.250'], ['D13.444.308.568'], ['D27.720.470.410.360'], ['D27.720.470.480'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.196.867.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Blockade of adrenaline-induced hyperglycaemia in the anaesthetized cat by continuous infusion of phentolamine and propranolol. | 1 The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (1 microgram kg-1 min-1) have been studied in the anaesthetized, fasted cat. 2 Propranolol, in doses (0.25 or 1 mg/kg) which prevented completely adrenaline-induced tachycardia, reduced but did not abolish adrenaline-induced ... | ['Anesthesia', 'Animals', 'Blood Glucose', 'Blood Pressure', 'Cats', 'Epinephrine', 'Female', 'Heart Rate', 'Male', 'Phentolamine', 'Propranolol', 'Receptors, Adrenergic'] | 7,052,338 | [['E03.155'], ['B01.050'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['E01.370.600.875.500', 'G09.330.380.500']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prostaglandin E2-induced release of luteinizing hormone-releasing factor (LRF). | Prostaglandin E2 (PGE2) injected into the third ventricle (3rd V) of conscious ovariectomized rats bearing a permanent jugular cannula increased the percentage of plasma samples showing detectable immunoassayable LRF levels at 1, 3 and 5 min after injection. This percentage was small at 2 and 4 min. When plasma LRF and... | ['Animals', 'Castration', 'Female', 'Gonadotropin-Releasing Hormone', 'Hypothalamus', 'Luteinizing Hormone', 'Ovary', 'Prostaglandins E', 'Radioimmunoassay', 'Rats', 'Time Factors'] | 1,095,952 | [['B01.050'], ['E04.270.282', 'E04.950.165'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Australian government's review of positron emission tomography: evidence-based policy-making in action. | The Commonwealth Government constituted the Medicare Services Advisory Committee (MSAC) to implement its commitment to entrench the principles of evidence-based medicine in Australian clinical practice. With its recent review of positron emission tomography (PETReview), the Commonwealth intervened in an established MSA... | ['Australia', 'Benchmarking', 'Data Interpretation, Statistical', 'Evidence-Based Medicine', 'Humans', 'Policy Making', 'Reproducibility of Results', 'Research Design', 'Technology Assessment, Biomedical', 'Tomography, Emission-Computed'] | 15,200,360 | [['Z01.639.100', 'Z01.678.100.373'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400... | ['Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Expression of a decorin-like moleculein human melanoma. | Decorin, a member of the family of small leucin-rich proteoglycans, has originally been described as a secreted proteoglycan component of the connective tissues, and has been implicated in the negative regulation of cell proliferation directly or via interactions with TGF-beta. It was reported to be generally absent fr... | ['Animals', 'Blotting, Southern', 'Cell Division', 'Cell Transformation, Neoplastic', 'Collagenases', 'DNA Primers', 'Decorin', 'Extracellular Matrix Proteins', 'Flow Cytometry', 'Immunoenzyme Techniques', 'Melanoma', 'Mice', 'Mice, SCID', 'Neoplasm Metastasis', 'Polymerase Chain Reaction', 'Proteoglycans', 'RNA, Messe... | 11,882,905 | [['B01.050'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D09.698... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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