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Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents. | Hepatocyte nuclear factor 4 alpha (HNF4á), the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation by way of unknown mechanisms. We investigated the mechanisms of HNF4á-induced inhibition of hepatocyte proliferation using a novel tamoxifen (TAM)-inducible, hepatoc... | ['Animals', 'Carcinoma, Hepatocellular', 'Cell Proliferation', 'Diethylnitrosamine', 'Disease Progression', 'Gene Deletion', 'Gene Expression Profiling', 'Hepatocyte Nuclear Factor 4', 'Hepatocytes', 'Homeostasis', 'Liver Neoplasms, Experimental', 'Male', 'Mice', 'Mice, Knockout', 'Sequence Analysis, RNA', 'Tamoxifen',... | 23,315,968 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.654.442.200'], ['C23.550.291.656'], ['G05.365.590.762.320', 'G05.558.800.320'], ['E05.393.332'], ['D12.776.260.262.968', 'D12.776.660.352.968', 'D12.776.826.119', 'D12.77... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interlimb coordination in 20-day-old rat fetuses. | Evidence for short sequences of interlimb coordination was found in 20-day-old rat fetuses. Frame-by-frame analysis of videotape records showed phase relationships indicating a pattern of alternation in sequences involving forelimb-forelimb and hindlimb-hindlimb coordination. Forelimb-hindlimb coordination was not obse... | ['Animals', 'Extremities', 'Female', 'Fetus', 'Functional Laterality', 'Locomotion', 'Movement', 'Pregnancy', 'Rats', 'Videotape Recording'] | 7,462,983 | [['B01.050'], ['A01.378'], ['A16.378'], ['F02.830.297.425', 'G11.561.225.425'], ['G07.568.500', 'G11.427.410.568'], ['G07.568', 'G11.427.410'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['J01.897.280.500.846.734', 'J01.897.280.500.898.840', 'L01.178.590.875.840', 'L01.178.820.090.846.734', 'L01.... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The cuprizone model: regional heterogeneity of pathology. | The cuprizone model is a model of de- and remyelination secondary to oligodendrocyte death, likely to be mediated by an inhibition of mitochondrial function. The aim of this study was to characterize histopathological changes associated with de/remyelination in grey and white matter at different disease stages in C57Bl... | ['Animals', 'Cerebral Cortex', 'Complement System Proteins', 'Corpus Callosum', 'Cuprizone', 'Demyelinating Diseases', 'Female', 'Gliosis', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Lymphocytes', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Microglia', 'Mitochondria', 'Multiple Sclerosis', 'Myelin Sheath', 'Oligod... | 22,779,688 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['D12.776.124.486.274'], ['A08.186.211.200.885.800.750'], ['D02.455.426.392.368.367.190'], ['C10.314'], ['C23.550.369'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['A11.329.372', 'A11.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Non-invasive continuous arterial pressure, heart rate and stroke volume measurements during graded head-up tilt in normal man. | The haemodynamic effects of head-up tilt (HUT) at different tilt angles were investigated non-invasively in eight normal male subjects. Mean arterial pressure (MAP; by Ohmeda Finapres 2300), stroke volume (SV) and heart rate (HR; by BoMed NCCOM3-R7S) were continuously recorded whilst performing a series of HUTs (55 deg... | ['Adult', 'Blood Pressure', 'Head-Down Tilt', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Posture', 'Reference Values', 'Reproducibility of Results', 'Stress, Physiological', 'Stroke Volume'] | 9,174,658 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G11.427.695.300'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['G11.427.695'], ['E05.978.810'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fatal choking in infants and children treated in a pediatric intensive care unit: A 7- year experience. | INTRODUCTION: Foreign bodies aspiration can lead to significant morbidity, few have examined in detail the deaths resulting from foreign bodies aspiration.METHODS: We conducted a review of children who presented to the pediatric intensive care unit of a university hospital due to fatal foreign bodies aspiration during ... | ['Airway Obstruction', 'Asphyxia', 'Child', 'Child, Preschool', 'Female', 'Food', 'Foreign Bodies', 'Humans', 'Infant', 'Intensive Care Units, Pediatric', 'Male', 'Respiratory Aspiration'] | 29,859,591 | [['C08.618.846.185'], ['C23.550.260.095', 'C26.103'], ['M01.060.406'], ['M01.060.406.448'], ['G07.203.300', 'J02.500'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N02.278.388.493.390'], ['C08.618.749', 'C23.550.773']] | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Apparent Young's modulus of vertebral cortico-cancellous bone specimens. | Up to now, due to cortical thickness and imaging resolution, it is not possible to derive subject-specific mechanical properties on the 'vertebral shell' from imaging modalities applicable in vivo. As a first step, the goal of this study was to assess the apparent Young's modulus of vertebral cortico-cancellous bone sp... | ['Aged', 'Compressive Strength', 'Computer Simulation', 'Connective Tissue', 'Elastic Modulus', 'Female', 'Finite Element Analysis', 'Humans', 'In Vitro Techniques', 'Lumbar Vertebrae', 'Male', 'Materials Testing', 'Models, Biological', 'Tensile Strength', 'Thoracic Vertebrae'] | 21,749,276 | [['M01.060.116.100'], ['G01.374.180'], ['L01.224.160'], ['A10.165'], ['G01.374.590.605'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A02.835.232.834.519'], ['E05.570'], ['E05.599.395'], ['G01.374.850'], ['A02.835.232.834.892']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Central retinal artery occlusion in a 13-year-old child as a presenting sign of hyperhomocysteinemia together with high lipoprotein(a) level. | BACKGROUND: We describe a child with central retinal artery occlusion and hyperhomocysteinemia.METHODS: A 13-year-old girl developed sudden vision loss and was hospitalized for diagnosis and treatment.RESULTS: Her physical examination was normal except for her ophthalmologic examination. Her serum homocysteine level an... | ['Adolescent', 'Female', 'Fluorescein Angiography', 'Humans', 'Hyperhomocysteinemia', 'Lipoprotein(a)', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'Mutation', 'Papilledema', 'Retinal Artery Occlusion', 'Tomography, Optical Coherence'] | 23,859,863 | [['M01.060.057'], ['E01.370.370.050.350', 'E01.370.380.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.320.565.100.480', 'C18.452.603.378', 'C18.452.648.100.480', 'C18.654.521.500.133.699.418'], ['D10.532.350', 'D12.776.521.400'], ['D08.811.682.662.290', 'D12.776.331.775'], ['G05.365.590'], ['C10.292.700.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Internal fixation with occipital hooks construct for occipito-cervical arthrodesis. Results in 14 young or small children. | PURPOSE: Evaluation of effectiveness of internal rigid fixation for occipito-cervical fusion with occipital hooks and cervical screws and/or hooks to improve fusion in young or small children with various bone dysplasia or congenital abnormality.METHODS: Fourteen children with mean age of 8.4 years and height and weigh... | ['Adolescent', 'Atlanto-Occipital Joint', 'Cervical Vertebrae', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Osseointegration', 'Retrospective Studies', 'Spinal Fusion'] | 24,997,617 | [['M01.060.057'], ['A02.835.583.101'], ['A02.835.232.834.151'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.213.140.570', 'G16.762.150.150.570'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Immunoglobulin heavy chain gene rearrangements in the monoclonal gammopathies]. | Plasma cell neoplasia occurs as a result of the expansion of an immunoglobulin-secreting B-cells clones, known as monoclonal component or M component. Malignant neoplasias include multiple myeloma and Waldenstrom macroglobulinemia, while premalignant conditions comprise monoclonal gammopathies of unknown significance (... | ['Aged', 'Aged, 80 and over', 'Bone Marrow', 'Female', 'Flow Cytometry', 'Gene Rearrangement, B-Lymphocyte, Heavy Chain', 'Humans', 'Immunophenotyping', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Paraproteinemias', 'Polymerase Chain Reaction', 'Sensitivity and Specificity'] | 16,042,132 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A15.382.216'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.344.401.501', 'G12.500.274.501'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expedient route to the tigliane-daphnane skeleton via oxonium ylide [1,2]-shift. | A short, stereoselective approach to the fused tricyclic carbon skeleton found in the tigliane and daphnane classes of diterpene natural products is described. Convergent coupling of the A- and C-rings, followed by diastereoselective cerium enolate addition and formation of a double acetal set the stage for generation ... | ['Biological Products', 'Diterpenes', 'Molecular Structure', 'Stereoisomerism'] | 21,241,059 | [['D20.215'], ['D02.455.849.291'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of ocular surface disease in glaucoma patients. | PURPOSE: To examine the prevalence of ocular surface disease (OSD) in glaucoma patients.METHODS: This was a cross-sectional study. One hundred and one patients, 18 years of age or older, with open-angle glaucoma or ocular hypertension were consecutively recruited for the study. Patients with a history of use of cyclosp... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antihypertensive Agents', 'Benzalkonium Compounds', 'Coloring Agents', 'Conjunctiva', 'Cornea', 'Cross-Sectional Studies', 'Dry Eye Syndromes', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Lissamine Green Dyes', 'Male', 'Middle Aged', 'Ocular Hypertension'... | 18,703,943 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.411.162'], ['D02.092.877.096.040', 'D02.675.276.080'], ['D27.720.233'], ['A09.371.060.200', 'A09.371.337.168'], ['A09.371.060.217'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C11.496.260'], ['C11.525.381... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microplastic transport in soil by earthworms. | Despite great general benefits derived from plastic use, accumulation of plastic material in ecosystems, and especially microplastic, is becoming an increasing environmental concern. Microplastic has been extensively studied in aquatic environments, with very few studies focusing on soils. We here tested the idea that ... | ['Animals', 'Behavior, Animal', 'Oligochaeta', 'Particle Size', 'Polyethylene', 'Soil', 'Soil Pollutants'] | 28,465,618 | [['B01.050'], ['F01.145.113'], ['B01.050.500.091.657'], ['G02.712'], ['D02.455.326.271.665.550.500', 'D05.750.716.507.500', 'D25.720.716.507.500', 'J01.637.051.720.716.507.500'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.888.284.756']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins. | The study of osteoclast integrins has been previously hampered by the lack of a source of large numbers of purified osteoclasts. Osteoclastoma, a human giant cell tumor of bone, supplied a rich source of osteoclasts within a tissue containing many diverse cell types. Osteoclastoma integrin immunostaining confirmed the ... | ['Amino Acid Sequence', 'Fluorescent Antibody Technique', 'Giant Cell Tumors', 'Humans', 'In Situ Hybridization', 'Integrins', 'Microscopy, Immunoelectron', 'Molecular Sequence Data', 'Osteoclasts', 'Precipitin Tests'] | 8,344,953 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['C04.557.450.565.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Characterisation of the alpha 1-protease inhibitor system in Thoroughbred horse plasma by horizontal two-dimensional (ISO-DALT) electrophoresis. 2. Protease inhibition. | The protease inhibitory spectra of the eight homozygous Thoroughbred Pi types against trypsin, elastase and chymotrypsin have been determined. The alpha 1-protease inhibitor proteins exhibit three classes of inhibitory specificity towards these enzymes. The Pi types F, I, N and U exhibit class I (trypsin, elastase and ... | ['Animals', 'Blood Proteins', 'Chymotrypsin', 'Electrophoresis, Polyacrylamide Gel', 'Isoelectric Focusing', 'Molecular Weight', 'Pancreatic Elastase', 'Protease Inhibitors', 'Trypsin Inhibitors', 'alpha 1-Antitrypsin'] | 6,604,473 | [['B01.050'], ['D12.776.124'], ['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.196.401.663', 'E05.301.300.663'], ['G02.494'], ['D08.811.277.656.300.760.560', 'D08.811.277.656.959.350.560'], ['D27.505.519.389.745'], ['D27.505.519.389.745.800.900'], ['D12.644.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Citalopram in premenstrual dysphoria: is intermittent treatment during luteal phases more effective than continuous medication throughout the menstrual cycle? | In a double-blind trial, the selective serotonin reuptake inhibitor citalopram was administered to women with severe irritability and/or depressed mood in the luteal but not in the follicular phase of the menstrual cycle (premenstrual dysphoria). Treatment continued for three consecutive menstrual cycles. One group (N ... | ['Adult', 'Antidepressive Agents, Second-Generation', 'Citalopram', 'Depression', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Female', 'Humans', 'Irritable Mood', 'Luteal Phase', 'Premenstrual Syndrome', 'Treatment Outcome'] | 9,790,157 | [['M01.060.116'], ['D27.505.954.427.700.122.050'], ['D02.092.831.170', 'D02.626.320', 'D03.633.100.127.187'], ['F01.145.126.350'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.470.047.110'], ['G08.686.605.410'], ['C23.550.568.968'], ['E01.789.800', 'N04... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Surface-enhanced Raman spectra analysis of trace degradation products from goat horn]. | Nano-silver colloid was synthesized by using microwave method on the mixtures of sodium citrate solution and silver nitrate solution. The method has advantages of fast heating speed, uniform temperature distribution and easily controlled reaction conditions. The sizes and size distributions of the silver particles were... | ['Animals', 'Colloids', 'Goats', 'Horns', 'Metal Nanoparticles', 'Microwaves', 'Particle Size', 'Silver', 'Spectrum Analysis, Raman'] | 25,007,614 | [['B01.050'], ['D20.280', 'D26.255.165'], ['B01.050.150.900.649.313.500.380.513'], ['A13.507'], ['J01.637.512.600.500'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['G02.712'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['E05.196.822.860', 'E05.196.867.890']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Structural insight into translesion synthesis by DNA Pol II. | E. coli DNA Pol II and eukaryotic Rev3 are B-family polymerases that can extend primers past a damaged or mismatched site when the high-fidelity replicative polymerases in the same family are ineffective. We report here the biochemical and structural properties of DNA Pol II that facilitate this translesion synthesis. ... | ['Crystallography, X-Ray', 'DNA Damage', 'DNA Polymerase II', 'DNA, Bacterial', 'Escherichia coli', 'Models, Molecular', 'Protein Structure, Tertiary'] | 20,064,374 | [['E05.196.309.742.225'], ['G05.200'], ['D08.811.913.696.445.308.300.230'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.599.595'], ['G02.111.570.820.709.610']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chimeric drift in allophenic mice: analysis of changes in red blood cell and white blood cell populations in C57Bl/6 in equilibrium (A X SJL)F1, C57Bl/6 in equilibrium (CBA X CBA/H-T6)F1, and C57Bl/6 in equilibrium DBA/1 mice. | Forty-seven allophenic mice of three different types (C57BL/6 in equilibrium (A X SJL), C57BL/6 in equilibrium (CBA X CBA/H-T6), and C57BL/6 in equilibrium DBA/1) were analyzed for changes in their peripheral white blood cell composition and hemoglobin composition with age. It was found that 10 of the 47 mice showed si... | ['Aging', 'Animals', 'Chimera', 'Electrophoresis, Polyacrylamide Gel', 'Erythrocytes', 'Female', 'H-2 Antigens', 'Hemoglobins', 'Isoelectric Focusing', 'Leukocytes', 'Male', 'Mice', 'Mice, Inbred A', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Mice, Inbred DBA', 'Mice, Inbred Strains'] | 595,125 | [['G07.345.124'], ['B01.050'], ['B05.200'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D23.050.301.500.100.350', 'D23.050.301.500.400.199', 'D23.050.705.552.100.350', 'D23.050.705.552.410.199'], ['D12.776.124.400', 'D12.776.422.316.762'], ['E05.196.401.663', 'E05.301.30... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. | Src-like adaptor protein (SLAP) and c-Cbl recently have been shown to cooperate in regulating T cell receptor (TCR) levels in developing T cells. SLAP also is expressed in developing B cells, and its deficiency leads to alterations in B cell receptor (BCR) levels and B cell development. Hence, we hypothesized that SLAP... | ['Animals', 'B-Lymphocytes', 'Cell Differentiation', 'Cell Line, Tumor', 'Down-Regulation', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Protein Binding', 'Proto-Oncogene Proteins c-cbl', 'Proto-Oncogene Proteins pp60(c-src)', 'Receptors, Antigen, B-Cell'] | 17,110,436 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spread spectrum image watermarking based on perceptual quality metric. | Efficient image watermarking calls for full exploitation of the perceptual distortion constraint. Second-order statistics of visual stimuli are regarded as critical features for perception. This paper proposes a second-order statistics (SOS)-based image quality metric, which considers the texture masking effect and the... | ['Algorithms', 'Contrast Sensitivity', 'Data Compression', 'Databases, Factual', 'Image Interpretation, Computer-Assisted', 'Pattern Recognition, Automated', 'Perceptual Masking', 'Product Labeling', 'Visual Perception', 'Wavelet Analysis'] | 21,518,660 | [['G17.035', 'L01.224.050'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['L01.224.308.189', 'L01.224.800.500', 'L01.470.500'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. | Adult stem cells define a cellular reserve with the unique capacity to replenish differentiated cells of a tissue throughout an organism's lifetime. Previous analysis has demonstrated that the adult Drosophila midgut is maintained by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial ni... | ['Adenomatous Polyposis Coli Protein', 'Animals', 'Cell Differentiation', 'Cell Lineage', 'Cell Proliferation', 'Drosophila Proteins', 'Drosophila melanogaster', 'Homeostasis', 'Humans', 'Intestines', 'Signal Transduction', 'Stem Cells', 'Wnt Proteins'] | 19,502,486 | [['D05.500.117.249', 'D12.776.220.040', 'D12.776.476.081.249', 'D12.776.624.776.010'], ['B01.050'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G07.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. | Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium reabsorption in the renal proximal tubule. We report here that reactive oxygen species are required to initiate ouabain-stimulated Na/K-ATPase·c-Src signaling. Pretreatment with the antioxidant N-acetyl-L-cysteine prevented ouabain-sti... | ['Acetylcysteine', 'Animals', 'CSK Tyrosine-Protein Kinase', 'Cell Line', 'Enzyme Inhibitors', 'Free Radical Scavengers', 'Multienzyme Complexes', 'Ouabain', 'Protein Carbonylation', 'Proteolysis', 'Reactive Oxygen Species', 'Signal Transduction', 'Sodium-Potassium-Exchanging ATPase', 'Swine', 'src-Family Kinases'] | 24,121,502 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['D08.811.913.696.620.682.725.800.158'], ['A11.251.210'], ['D27.505.519.389'], ['D27.505.519.217.500'], ['D05.500.562', 'D08.811.600'], ['D04.210.500.155.580.130.750.600', 'D09.408.180.810.600'], ['G02.111.660.871.790.600.350', 'G02.111.691.600.350', 'G03.67... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cardiorespiratory responses of patients with rheumatoid arthritis during bicycle riding and running in water. | BACKGROUND AND PURPOSE: The purpose of this study was to compare exercise during dry-land bicycle ergometry and running in water with a flotation device in individuals with rheumatoid arthritis.SUBJECTS: Eight individuals with adult-onset rheumatoid arthritis, between the ages of 30 and 40 years (X = 35.88, SD = 2.85),... | ['Adult', 'Arthritis, Rheumatoid', 'Exercise Test', 'Exercise Therapy', 'Female', 'Heart Rate', 'Humans', 'Immersion', 'Lung Volume Measurements', 'Oxygen Consumption', 'Physical Exertion', 'Running'] | 8,863,759 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.466'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Galactosyl transferase assay. Application to experimental atherosclerosis. | To establish a repetitive measurement, aortic galactosyl transferase activity has been studied with a specific exogenous acceptor, collagen. Reactions were realized with an acellular biosynthesis mixture containing, collagen (3-4 mg/ml) an aliquot of enzymatic extract preparation (105000 g supernatant (2-3 mg/ml of pro... | ['Aminopropionitrile', 'Animals', 'Aorta', 'Arteriosclerosis', 'Collagen', 'Diet, Atherogenic', 'Disease Models, Animal', 'Enzyme Activation', 'Galactosyltransferases', 'Lathyrism', 'Manganese', 'Rabbits', 'Stimulation, Chemical', 'Uridine Diphosphate Galactose'] | 796,808 | [['D02.626.151'], ['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G07.203.650.240.242'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.263', 'G03.328'], ['D08.811.913.400.450.400'], ['C25.723.756.558'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metastatic renal cell carcinoma to the remaining kidney 14 years after nephrectomy: report of two cases. | In two patients with renal cell carcinoma, late metastases to the remaining kidney were found. The metastases were histologically identical to the primary tumor, and more than one nodule recurred in both cases. Advanced surgical techniques allowing removal of metastases from the sole kidney make diagnosis of these lesi... | ['Adenocarcinoma', 'Female', 'Humans', 'Kidney Neoplasms', 'Middle Aged', 'Neoplasm Metastasis', 'Nephrectomy', 'Tomography, X-Ray Computed'] | 436,132 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suicides on Ontario farms. | PURPOSE: To describe the epidemiology of suicides on Ontario farms from 1980-1989, and the ecological relationship between economic strain and farm suicide risk.METHOD: Farm suicides were identified using a computer-assisted search of vital records. Distributions of farm suicides were examined by several demographic va... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Agriculture', 'Child', 'Child, Preschool', 'Databases, Factual', 'Death Certificates', 'Female', 'Humans', 'Infant', 'Linear Models', 'Male', 'Middle Aged', 'Ontario', 'Ownership', 'Population Surveillance', 'Poverty', 'Regression Analysis', 'Risk Factors', 'Suicide'] | 8,221,493 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['J01.040'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.308.940.350', 'L01.399.250.900.350', 'N04.452.859.264', 'N05.715.360.300.715.315', 'N06.850.520.308.940.350'], ... | ['Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Global health-related publications in otolaryngology are increasing. | OBJECTIVES/HYPOTHESIS: Determine trends in global health-related publication in otolaryngology.STUDY DESIGN: A review of research databases.METHODS: A search of publications available on PubMed and nine additional databases was undertaken reviewing two time periods 10 years apart for the timeframes 1998 to 2002 (early ... | ['Databases, Factual', 'Forecasting', 'Global Health', 'Humans', 'Incidence', 'Otolaryngology', 'Serial Publications'] | 25,155,277 | [['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['I01.320'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['H02.403.810.526'], ['L01.178.682.829']] | ['Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
[The functional status of the brain in patients with abdominal aortic aneurysm]. | We performed electroencephalography to 11 patients with abdominal aortic aneurysm in order to investigate the functional status of the brain. The relative potency (RP) of the main rhythms (alpha, beta, teta and delta) was increased, as well as the beta/alpha activation ratio. The increase of low-frequency rhythms (delt... | ['Adult', 'Aged', 'Aortic Aneurysm, Abdominal', 'Brain', 'Delta Rhythm', 'Electroencephalography', 'Female', 'Functional Laterality', 'Humans', 'Hyperventilation', 'Hypoxia, Brain', 'Male', 'Middle Aged', 'Respiratory System'] | 19,051,416 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['A08.186.211'], ['E01.370.376.300.150.875', 'E01.370.405.245.287.875', 'G07.265.087.875', 'G11.561.127.875'], ['E01.370.376.300', 'E01.370.405.245'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Excretory function of the liver with an allyl alcohol lesion and the antioxidant correction of the disorders]. | In experiments on 33 albino male rats it was established that during allyl alcohol-induced damage of the liver its excretory function is impaired that was judged by the biliary excretion of intravenously injected Bengal pink-131I. Antioxidants (tocopherol acetate, sodium selenite, unithiol) reduced the toxic effect of ... | ['1-Propanol', 'Animals', 'Antioxidants', 'Chemical and Drug Induced Liver Injury', 'Drug Evaluation, Preclinical', 'Iodine Radioisotopes', 'Liver', 'Male', 'Propanols', 'Radionuclide Imaging', 'Rats', 'Rose Bengal', 'Time Factors'] | 3,556,542 | [['D02.033.755.600'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['E05.290.750', 'E05.337.550'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['A03.620'], ['D02.033.755'], ['E01.370.350.710', 'E01.370.384.730'], ['B01.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dendritic calcium accumulation regulates wind sensitivity via short-term depression at cercal sensory-to-giant interneuron synapses in the cricket. | An in vivo Ca2+ imaging technique was applied to examine the cellular mechanisms for attenuation of wind sensitivity in the identified primary sensory interneurons in the cricket cercal system. Simultaneous measurement of the cytosolic Ca2+ concentration ([Ca2+]i) and membrane potential of a wind-sensitive giant intern... | ['Action Potentials', 'Air Pressure', 'Animals', 'Calcium', 'Calcium Signaling', 'Chelating Agents', 'Dendrites', 'Egtazic Acid', 'Electric Stimulation', 'Excitatory Postsynaptic Potentials', 'Ganglia, Invertebrate', 'Gryllidae', 'Interneurons', 'Male', 'Mechanoreceptors', 'Neural Inhibition', 'Neuronal Plasticity', 'S... | 11,180,157 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G16.500.750.274.100', 'N06.230.300.100.185.100'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D27.505.519.914.500', 'D27.720.832.500'], ['A08.675.256', 'A11.284.180.225', 'A... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quantitative analysis of pulsatile flow contribution to ultrafiltration. | We evaluated the quantitative contribution of pulsatile flow to ultrafiltration (UF) in terms of fluid power, membrane stretch, and reduction of membrane layering. An in vitro comparison of the UF rate using pulsatile and roller pumps was performed with distilled water and bovine whole blood. The mean transmembrane pre... | ['Biomechanical Phenomena', 'Hemofiltration', 'Models, Cardiovascular', 'Pulsatile Flow'] | 19,178,443 | [['G01.154.090', 'G01.374.089'], ['E02.870.225', 'E04.292.471'], ['E05.599.395.161'], ['G01.482.620', 'G09.330.380.630.555']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy. | Body composition is sparsely described in spinal muscular atrophy (SMA). Body (BMI, mass/height in m(2)), fat-free (FFMI, lean mass/height in m(2)) and fat (FMI, fat mass/height in m(2)) mass indexes were estimated in 25 children (aged 5-18) with SMA (2 type I, 13 type II, 10 type III) using dual-energy radiograph abso... | ['Absorptiometry, Photon', 'Adipose Tissue', 'Adolescent', 'Anthropometry', 'Body Composition', 'Body Mass Index', 'Child', 'Child, Preschool', 'Cohort Studies', 'Female', 'Humans', 'Incidence', 'Male', 'Muscular Atrophy, Spinal', 'Overweight', 'ROC Curve'] | 19,427,208 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['A10.165.114'], ['M01.060.057'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406'], ['M01.060.406.448'], ['E05.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lower limb joint work and joint work contribution during downhill and uphill walking at different inclinations. | Work performance and individual joint contribution to total work are important information for creating training protocols, but were not assessed so far for sloped walking. Therefore, the purpose of this study was to analyze lower limb joint work and joint contribution of the hip, knee and ankle to total lower limb wor... | ['Adult', 'Biomechanical Phenomena', 'Gait', 'Humans', 'Joints', 'Kinetics', 'Lower Extremity', 'Male', 'Walking'] | 28,734,544 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583'], ['G01.374.661', 'G02.111.490'], ['A01.378.610'], ['G11.427.410.568.900', 'G11.427.410.698.277.937', 'I03.350.937', 'I03.450.642.845.940']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Crystal structure of a human mitochondrial deoxyribonucleotidase. | 5' nucleotidases are ubiquitous enzymes that dephosphorylate nucleoside monophosphates and participate in the regulation of nucleotide pools. The mitochondrial 5'-(3') deoxyribonucleotidase (dNT-2) specifically dephosphorylates dUMP and dTMP, thereby protecting mitochondrial DNA replication from excess dTTP. We have so... | ["5'-Nucleotidase", 'Amino Acid Sequence', 'Beryllium', 'Binding Sites', 'Crystallography, X-Ray', 'Fluorides', 'Humans', 'Mitochondria', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Sequence Alignment', 'Thymidine'] | 12,352,955 | [['D08.811.277.352.650.600.600'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D01.268.552.075', 'D01.268.557.080', 'D01.552.547.080'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.564', 'A11.284.835... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Variants within the MMP3 gene and patellar tendon properties in vivo in an asymptomatic population. | BACKGROUND/AIM: Gene variants encoding for proteins involved in homeostatic processes within tendons may influence its material and mechanical properties in humans. The purpose of this study was to examine the association between three polymorphisms of the MMP3 gene, (rs679620, rs591058 and rs650108) and patellar tendo... | ['Adolescent', 'Adult', 'Biomechanical Phenomena', 'Elastic Modulus', 'Electromyography', 'Female', 'Genetic Association Studies', 'Genotype', 'Humans', 'Isometric Contraction', 'Male', 'Matrix Metalloproteinase 3', 'Muscle, Skeletal', 'Organ Size', 'Patellar Ligament', 'Polymorphism, Genetic', 'Young Adult'] | 25,168,209 | [['M01.060.057'], ['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['G01.374.590.605'], ['E01.370.405.255', 'E01.370.530.255'], ['E05.393.385'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['D08.811.277.656.300.480.525.700.200', 'D08.811.277.656.675.374.525.700.200', 'D12.644.276.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Accuracy of diagnostic mammography at facilities serving vulnerable women. | BACKGROUND: Breast cancer missed on diagnostic mammography may contribute to delayed diagnoses, whereas false-positive results may lead to unnecessary invasive procedures. Whether accuracy of diagnostic mammography at facilities serving vulnerable women differs from other facilities is unknown.OBJECTIVE: To compare the... | ['Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Humans', 'Mammography', 'Middle Aged', 'Residence Characteristics', 'Sensitivity and Specificity', 'Socioeconomic Factors', 'Vulnerable Populations'] | 20,966,780 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['M01.060.116.630'], ['N01.224.791', 'N06.850.505.400.800'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.4... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Development and characterization of CHO repair-proficient cell lines for comparative mutagenicity and metabolism of heterocyclic amines from cooked food. | In order to understand the role of repair and metabolism in the mutagenicity of heterocyclic amines from cooked foods, we previously developed the nucleotide excision repair-deficient CHO 5P3NAT2 cell line engineered to coexpress the mouse CYP1A2 and human N-acetyltransferase genes. In the present study, we have made a... | ['Amines', 'Animals', 'Arylamine N-Acetyltransferase', 'CHO Cells', 'Cell Death', 'Cell Line', 'Cooking', 'Cricetinae', 'Cytochrome P-450 CYP1A2', 'DNA Repair', 'Ethyl Methanesulfonate', 'Food', 'Heterocyclic Compounds', 'Mutagenicity Tests', 'Mutagens', 'Quinolines', 'Sequence Analysis, DNA'] | 12,552,587 | [['D02.092'], ['B01.050'], ['D08.811.913.050.134.138'], ['A11.251.210.200', 'A11.436.155'], ['G04.146'], ['A11.251.210'], ['J01.576.423.200.200'], ['B01.050.150.900.649.313.992.635.075.250'], ['D08.244.453.005.443', 'D08.244.453.100.750', 'D08.811.682.690.708.170.010.443', 'D08.811.682.690.708.170.020.750', 'D12.776.42... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ketone Body Infusion With 3-Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study. | BACKGROUND: High levels of ketone bodies are associated with improved survival as observed with regular exercise, caloric restriction, and-most recently-treatment with sodium-glucose linked transporter 2 inhibitor antidiabetic drugs. In heart failure, indices of ketone body metabolism are upregulated, which may improve... | ['3-Hydroxybutyric Acid', 'Aged', 'Carbon Radioisotopes', 'Coronary Circulation', 'Female', 'Fluorodeoxyglucose F18', 'Glucose', 'Glucose Clamp Technique', 'Healthy Volunteers', 'Heart', 'Heart Rate', 'Humans', 'Ketone Bodies', 'Male', 'Middle Aged', 'Myocardium', 'Oxygen Radioisotopes', 'Palmitates', 'Positron Emissio... | 28,242,634 | [['D02.241.081.114.937.349', 'D02.241.511.429.349', 'D02.522.585.087', 'D10.251.400.143.781.500'], ['M01.060.116.100'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['G09.330.100.324'], ['D09.254.229.500'], ['D09.947.875.359.448'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['M... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Microwave-assisted extraction and determination of cyanuric acid residue in pet food samples by liquid chromatography-tandem mass spectrometry. | Cyanuric acid (CYA) is attracting more attention due to its potential toxicity. In the present work, microwave-assisted extraction method in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was proposed for the determination of CYA in pet food samples. Among different solvents, diethylamine-ac... | ['Animal Feed', 'Chemical Fractionation', 'Chromatography, High Pressure Liquid', 'Drug Residues', 'Food Contamination', 'Microwaves', 'Tandem Mass Spectrometry', 'Triazines'] | 21,298,779 | [['G07.203.300.300.100', 'J02.500.300.100'], ['E05.196.155'], ['E05.196.181.400.300'], ['N06.850.460.200.250'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['E05.196.566.880'], ['D03.383.931']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
ASSESSING THE USEFULNESS OF THE QUASI-IDEAL OBSERVER FOR QUALITY CONTROL IN FLUOROSCOPY. | The aim of this work was to evaluate the reliability of the square of the signal-to-noise ratio rate, [Formula: see text], as a precise measurement for quality control test in a digital fluoroscopy system. The quasi-ideal model observer was used to measure [Formula: see text] The dose rate, pulse rate and field of view... | ['Algorithms', 'Equipment Design', 'Equipment Failure Analysis', 'Fluoroscopy', 'Quality Assurance, Health Care', 'Quality Control', 'Radiographic Image Interpretation, Computer-Assisted', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Signal-To-Noise Ratio', 'Sweden'] | 26,493,947 | [['G17.035', 'L01.224.050'], ['E05.320'], ['E05.325.192'], ['E01.370.350.700.225'], ['N04.761.700', 'N05.700'], ['J01.897.608'], ['E01.158.600.680', 'E01.370.350.350.700', 'E01.370.350.700.705', 'L01.313.500.750.100.158.600.680'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids. | [reaction: see text] The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from comm... | ['Alkynes', 'Amino Acids', 'Catalysis', 'Cyclopropanes', 'Molecular Structure', 'Stereoisomerism'] | 15,760,158 | [['D02.455.326.397'], ['D12.125'], ['G02.130'], ['D02.455.426.392.368.533'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alcohol does not modulate the augmented acetylcholine-induced vasodilatory response in hemorrhaged rodents. | Our previous studies have shown that acute alcohol intoxication (AAI) decreases blood pressure, exacerbates hypotension after hemorrhagic shock, impairs the pressor response to fluid resuscitation, and blunts neuroendocrine activation. We hypothesized that impaired hemodynamic compensation during and after hemorrhagic ... | ['Acetylcholine', 'Alcoholic Intoxication', 'Animals', 'Aorta, Thoracic', 'Central Nervous System Depressants', 'Dose-Response Relationship, Drug', 'Ethanol', 'Hemorrhage', 'Male', 'Phenylephrine', 'Rats', 'Rats, Sprague-Dawley', 'Resuscitation', 'Shock', 'Vasodilation'] | 19,197,228 | [['D02.092.211.111'], ['C25.775.100.175', 'F03.900.100.300'], ['B01.050'], ['A07.015.114.056.372'], ['D27.505.696.277', 'D27.505.954.427.210'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.375'], ['C23.550.414'], ['D02.033.100.291.617', 'D02.092.063.291.617'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiotensin II induces apoptosis in rat glomerular epithelial cells. | ANG II has been shown to modulate kidney cell growth and contribute to the pathobiology of glomerulosclerosis. Glomerular visceral epithelial cell (GEC) injury or loss is considered to play a pivotal role in the initiation and progression of glomerulosclerosis. In the present study, we investigated the effect of ANG II... | ['Angiotensin II', 'Angiotensin Receptor Antagonists', 'Animals', 'Antibodies', 'Antihypertensive Agents', 'Cells, Cultured', 'DNA Fragmentation', 'Epithelial Cells', 'Fas Ligand Protein', 'Imidazoles', 'Kidney Glomerulus', 'Losartan', 'Membrane Glycoproteins', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-... | 12,060,599 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.519.162'], ['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D27.505.954.411.162'], ['A11.251'], ['G05.200.230'], ['A... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Streptococcus pneumoniae-induced pulmonary hypertension and systemic hypotension in anesthetized sheep. | Because some patients with Streptococcus pneumoniae bacteremia may present with shock, we reasoned that this organism may produce substances that cause shock. To test this hypothesis, type III pneumococcus supernatant, suspended in 10 ml of sterile water, was infused over 1 min in 8 adult anesthetized sheep. Normal sal... | ['15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Animals', 'Blood Pressure', 'Cardiac Output', 'Hypertension, Pulmonary', 'Hypotension', 'In Vitro Techniques', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Pneumococcal Infections', 'Potassium Chloride', 'Prostaglandin Endoperoxides, Syntheti... | 7,868,418 | [['D01.248.497.158.685.750.744.650.500.500', 'D01.339.431.374.744.650.500.500', 'D01.650.550.750.700.650.500.500', 'D02.389.338.638.650.500.500', 'D10.251.355.255.550.025.650.500.500', 'D23.469.050.175.725.025.650.500.500', 'D23.469.700.630.500'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Myocardial conduction time and antiarrhythmic drugs. | Complete a-v block was induced in anesthetized mongrel dogs by direct electrocoagulation of the a-v node. The ventricles were paced by steady stimulation (S1) at a rate of 100/min. and by test stimuli (S2) with varying post S1 delay. Right ventricular myocardial tension was measured from the S2 stimulation site of a sp... | ['Animals', 'Anti-Arrhythmia Agents', 'Cardiac Pacing, Artificial', 'Disopyramide', 'Dogs', 'Electrophysiology', 'Heart Conduction System', 'Lidocaine', 'Quinidine', 'Ventricular Function', 'Verapamil'] | 7,264,503 | [['B01.050'], ['D27.505.954.411.097'], ['E02.331.200'], ['D03.383.725.227'], ['B01.050.150.900.649.313.750.250.216.200'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541.409'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['D03.132.206.636', 'D03.605.687.637', 'D03.633.100.810.699'], ['G09.330.955'], ['D02.092... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mental disorder in the New South Wales prisoner population. | OBJECTIVES: To determine the prevalence of mental illness among prisoners in New South Wales (NSW), Australia.METHOD: Mental illness was examined in two NSW prisoner populations: (i) new receptions to the correctional system; and (ii) sentenced prisoners. Reception prisoners were screened at four male centres and one f... | ['Adult', 'Catchment Area, Health', 'Female', 'Humans', 'Male', 'Mental Disorders', 'New South Wales', 'Prevalence', 'Prisoners', 'Severity of Illness Index'] | 15,860,030 | [['M01.060.116'], ['N01.224.791.200', 'N03.349.650.095', 'N06.850.505.400.800.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['M01.729'], ['E05.... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. | OBJECTIVE: To report a case of refractory ulcerated necrobiosis lipoidica (NL) with significant response to treatment with topical tacrolimus.SUBJECT: A 55-year-old woman without diabetes and with a previous history of NL presented to the Helen L. and Martin S. Kimmel Hyperbaric and Advanced Wound Healing Center of NYU... | ['Administration, Topical', 'Biopsy, Needle', 'Chronic Disease', 'Compression Bandages', 'Female', 'Follow-Up Studies', 'Humans', 'Immunohistochemistry', 'Leg Ulcer', 'Long-Term Care', 'Middle Aged', 'Necrobiosis Lipoidica', 'Severity of Illness Index', 'Tacrolimus', 'Treatment Outcome', 'Wound Healing'] | 28,914,682 | [['E02.319.267.120'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C23.550.291.500'], ['E07.101.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.45... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Intramedullary nailing of femoral shaft fractures. Ten years' experience. | In 236 intramedullary nailings of femoral shaft fractures there was a 2 per cent deep infection rate, and a 7 per cent nonunion rate; 87 per cent had good primary healing; 42 per cent had further surgery after the initial nailing (two-thirds for removal of the nail). Statistical analysis of the data does not support th... | ['Adolescent', 'Adult', 'Aged', 'Bone Nails', 'Child', 'Femoral Fractures', 'Follow-Up Studies', 'Fracture Fixation, Intramedullary', 'Fractures, Ununited', 'Humans', 'Middle Aged'] | 1,261,123 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['M01.060.406'], ['C26.404.061', 'C26.558.276'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.555.300.300.300'], ['C26.404.468'], ['B01.0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synergistic action of A23187 and phorbol ester on human B cell activation. | We have investigated the existence of a synergy occurring between the calcium ionophore A23187 and phorbol myristic acetate (PMA) with respect to human B cell proliferation and differentiation. The combination of A23187 (250 to 500 nM) with nonmitogenic concentrations of PMA (1 to 3 ng/ml) resulted in a strong prolifer... | ['B-Lymphocytes', 'Calcimycin', 'Drug Synergism', 'Humans', 'Immunoglobulins', 'Lymphocyte Activation', 'Palatine Tonsil', 'Phorbols', 'Spleen', 'Tetradecanoylphorbol Acetate'] | 3,934,268 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D03.633.100.221.173'], ['G07.690.773.968.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'], ['E01.370.225.812.482', 'E05... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The use of botanicals for health purposes by members of a prepaid health plan. | Interviews were conducted with 100 adults (27 men, 73 women) enrolled in a prepaid medical health plan to investigate their use of botanical remedies. They were asked which of 50 listed herbs they or members of their families had used for health purposes and with what effect; which of 60 listed health problems they had... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Health Maintenance Organizations', 'Home Nursing', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Oregon', 'Phytotherapy', 'Plant Extracts', 'Self Care', 'Socioeconomic Factors', 'Urban Population'] | 1,891,620 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['E02.760.611.470', 'N02.421.143.524.470', 'N02.421.533.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.5... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
[Brucella meningitis: a case report]. | The authors report a case of genuine brucellar meningitis etiology. Emphasis was given on endemic and epidemiologic factors in our country as well as on contradictory clinical and complementary immunological tests in lower age groups. The CT scan ruled out possibilities of tissue damage. The case had good clinical evol... | ['Brucellosis', 'Humans', 'Male', 'Meningitis'] | 4,091,745 | [['C01.150.252.400.167'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.614']] | ['Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces. | The binding of proteins to cell surface carbohydrates contributes to cell-cell interactions in development, immunity, and various physiologic processes. Such interactions are presumably dictated not only by the chemical structure of the carbohydrate but also reflect the properties of the protein and the microenvironmen... | ['Animals', 'Antibody Specificity', 'Aorta', 'Carbohydrate Conformation', 'Carbohydrate Sequence', 'Cell Membrane', 'Cells, Cultured', 'Disaccharides', 'Endothelium, Vascular', 'Galactosides', 'Immunoglobulin M', 'Integrins', 'Membrane Glycoproteins', 'Molecular Sequence Data', 'Oligosaccharides', 'Sensitivity and Spec... | 9,597,541 | [['B01.050'], ['G12.100'], ['A07.015.114.056'], ['G02.111.570.820.235'], ['G02.111.570.160', 'L01.453.245.667.160'], ['A11.284.149'], ['A11.251'], ['D09.698.629.305', 'D09.947.750'], ['A07.015.700.500', 'A10.272.491.355'], ['D09.408.320'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.790.651.114.619.574', 'D12.776.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Methane-cycling communities in a permafrost-affected soil on Herschel Island, Western Canadian Arctic: active layer profiling of mcrA and pmoA genes. | In Arctic wet tundra, microbial controls on organic matter decomposition are likely to be altered as a result of climatic disruption. Here, we present a study on the activity, diversity and vertical distribution of methane-cycling microbial communities in the active layer of wet polygonal tundra on Herschel Island. We ... | ['Arctic Regions', 'Biota', 'Canada', 'DNA, Archaeal', 'Genes, Archaeal', 'Islands', 'Methane', 'Methanosarcinaceae', 'Oxidation-Reduction', 'Phylogeny', 'Polymorphism, Restriction Fragment Length', 'Soil', 'Soil Microbiology'] | 22,329,663 | [['Z01.208'], ['G16.500.275.157.049.100', 'N06.230.124.049.100'], ['Z01.107.567.176'], ['D13.444.308.180'], ['G05.360.340.024.340.364.124', 'G05.360.340.358.024.124', 'G05.360.340.358.050.500'], ['G16.500.275.505', 'N06.230.295', 'Z01.639'], ['D02.455.326.146.571'], ['B02.200.765.550'], ['G02.700', 'G03.295.531'], ['G0... | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Hepatic cryosurgery with and without the Bair Hugger. | Hypothermia is a significant clinical problem during hepatic cryosurgery, which at times causes the procedure to be halted until the patient's body temperature can be raised. This study examines the effects of the Bair Hugger (a warming device) on body temperature during hepatic cryosurgery. Twenty-eight cases of hepat... | ['Cryosurgery', 'Equipment Design', 'Heating', 'Humans', 'Hypothermia', 'Intraoperative Complications', 'Liver Neoplasms', 'Retrospective Studies'] | 8,441,278 | [['E04.014.180'], ['E05.320'], ['N06.230.150.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.119.565'], ['C23.550.505'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP. | The insulin receptor is known to interact with the SH2 domain proteins p85 (the regulatory subunit of phosphatidylinositol 3-kinase), Syp (a tyrosine phosphatase), and GAP (GTPase-activating protein). In this study, we mapped the insulin receptor binding sites for each of these proteins by examining the ability of phos... | ['Amino Acid Sequence', 'Animals', 'Binding Sites', 'GTPase-Activating Proteins', 'In Vitro Techniques', 'Intracellular Signaling Peptides and Proteins', 'Molecular Sequence Data', 'Phosphatidylinositol 3-Kinases', 'Phosphopeptides', 'Phosphotransferases (Alcohol Group Acceptor)', 'Phosphotyrosine', 'Protein Tyrosine P... | 7,525,547 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['D12.644.360.325.150', 'D12.776.476.325.150'], ['E05.481'], ['D12.644.360', 'D12.776.476'], ['L01.453.245.667'], ['D08.811.913.696.620.500'], ['D12.644.717'], ['D08.811.913.696.620'], ['D12.125.072.050.875.750', 'D12.125.740.740'], ['D08.81... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice. | BACKGROUND: Renoprotection of liver-type fatty acid binding protein (L-FABP) was demonstrated in a streptozotocin (STZ)-induced diabetic mouse model.METHODS: Established human L-FABP (hL-FABP) transgenic (Tg) mice and wild-type (WT) mice were divided into two groups: diabetic mice were uninephrectomized and injected wi... | ['Animals', 'Diabetes Mellitus, Experimental', 'Diabetic Nephropathies', 'Disease Models, Animal', 'Fatty Acid-Binding Proteins', 'Kidney Tubules', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Monocyte Chemoattractant Proteins', 'RNA, Messenger'] | 18,854,419 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.157.170'], ['A05.810.453.736.560'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.9... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Kinetic profile of the cellular lipid composition in an oleaginous Yarrowia lipolytica capable of producing a cocoa-butter substitute from industrial fats. | Cell growth, lipid accumulation and cellular lipid composition of Yarrowia lipolytica growing on mixtures of industrial fats containing stearic, oleic, linoleic and palmitic acid have been studied. During growth, the strain incorporated oleic and linoleic acids more rapidly than the saturated fatty acids. Relatively hi... | ['Culture Media', 'Dietary Fats', 'Fatty Acids, Monounsaturated', 'Fermentation', 'Kinetics', 'Lipid Metabolism', 'Lipids', 'Oleic Acid', 'Plant Oils', 'Rapeseed Oil', 'Stearic Acids', 'Yarrowia'] | 11,827,207 | [['D27.720.470.305', 'E07.206'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D10.251.355.325'], ['G02.111.158.249', 'G03.191.249'], ['G01.374.661', 'G02.111.490'], ['G03.458'], ['D10'], ['D10.251.355.325.600.525'], ['D10.627.700', 'D20.215.784.750'], ['D10.627.700.066', 'D20.215.784.750.066'], ['D10.251.882'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Disability acquisition and mental health: effect modification by demographic and socioeconomic characteristics using data from an Australian longitudinal study. | OBJECTIVES: There is evidence of a causal relationship between disability acquisition and poor mental health, but the substantial heterogeneity in the magnitude of the effect is poorly understood and may be aetiologically informative. This study aimed to identify demographic and socioeconomic factors that modify the ef... | ['Adult', 'Australia', 'Case-Control Studies', 'Demography', 'Disabled Persons', 'Female', 'Housing', 'Humans', 'Income', 'Interpersonal Relations', 'Longitudinal Studies', 'Male', 'Mental Health', 'Middle Aged', 'Propensity Score', 'Surveys and Questionnaires'] | 28,928,189 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['M01.150'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N0... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Comparative in vitro studies of self-boring and self-tapping screws. Histomorphological and physical-technical studies of bone layers]. | Self-drilling screws are gaining increasing importance in maxillofacial surgery. This study assesses which screw design, self-drilling or self-tapping, is best suited to various locations of the human skull. With regard to different areas in the human midface, mandible, and cranium, the thickness of cortical bone varie... | ['Animals', 'Bone Screws', 'Bone and Bones', 'Cattle', 'Equipment Design', 'Humans', 'Skull'] | 10,900,959 | [['B01.050'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.649.313.500.380.271'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hodgkin's disease. | This synthesis of the literature on radiotherapy for Hodgkin's Disease is based on 104 scientific articles, including 2 meta-analyses, 22 randomized studies, 5 prospective studies, and 58 retrospective studies. These studies involve 38,362 patients. The literature review clearly shows that radiotherapy is a cornerstone... | ['Combined Modality Therapy', 'Hodgkin Disease', 'Humans', 'Radiotherapy', 'Radiotherapy Dosage'] | 9,154,101 | [['E02.186'], ['C04.557.386.355', 'C15.604.515.569.355', 'C20.683.515.761.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.815'], ['E02.815.639']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Micro-computed tomography visualization of the vestigial alimentary canal in adult oestrid flies. | Oestrid flies (Diptera: Oestridae) do not feed during the adult stage as they acquire all necessary nutrients during the parasitic larval stage. The adult mouthparts and digestive tract are therefore frequently vestigial; however, morphological data on the alimentary canal in adult oestrid flies are scarce and a proper... | ['Animals', 'Digestive System', 'Diptera', 'Female', 'Male', 'Species Specificity', 'X-Ray Microtomography'] | 29,451,298 | [['B01.050'], ['A03'], ['B01.050.500.131.617.720.500.500.750'], ['G16.824'], ['E01.370.350.700.810.810.900', 'E01.370.350.825.810.810.900']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Coeliac disease and malignancies. | When compared with the general population, patients with coeliac disease (CD) have an increased risk of developing enteropathy-associated T-cell lymphoma (EATCL), esophageal and pharyngeal squamous carcinomas and small intestinal adenocarcinomas. The prevalence of histologically confirmed CD in Edinburgh and the Lothia... | ['Cause of Death', 'Celiac Disease', 'Female', 'Follow-Up Studies', 'Food Hypersensitivity', 'Glutens', 'Humans', 'Lymphoma, T-Cell', 'Lymphoproliferative Disorders', 'Male', 'Neoplasms', 'Registries', 'Serologic Tests'] | 8,783,767 | [['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C06.405.469.637.250', 'C18.452.603.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C20.543.480.370'], ['D12.776.765.433.500.500', 'D12.776.765.725.500.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Differential light perception threshold of the visual field and ERG following operatively attached retinal detachment]. | After surgical treatment of retinal detachment with a spontaneously pigmented demarcation line the visual fields of twelve patients were tested. The increment threshold of all positions (determined with the Octopus automatic perimeter system) was compared with the reduction in the scotopic and photopic ERG amplitudes (... | ['Adolescent', 'Adult', 'Electroretinography', 'Humans', 'Middle Aged', 'Postoperative Complications', 'Prognosis', 'Retinal Detachment', 'Sensory Thresholds', 'Visual Fields', 'Visual Perception'] | 4,021,423 | [['M01.060.057'], ['M01.060.116'], ['E01.370.380.225', 'E01.370.405.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E01.789'], ['C11.768.648'], ['F02.463.593.710'], ['F02.463.593.932.934', 'G14.950'], ['F02.463.593.932']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Automated DXA-based finite element analysis for hip fracture risk stratification: a cross-sectional study. | Fracture risk indices (FRIs) generated from DXA-based finite element analysis were associated with hip fracture independent of FRAX score computed with femoral neck bone mineral density (BMD). Prospective studies are warranted to determine whether FRIs represent an improvement over BMD for predicting incident hip fract... | ['Absorptiometry, Photon', 'Aged', 'Aged, 80 and over', 'Bone Density', 'Cross-Sectional Studies', 'Female', 'Femur Neck', 'Finite Element Analysis', 'Hip Fractures', 'Hip Joint', 'Humans', 'Manitoba', 'Osteoporosis, Postmenopausal', 'Osteoporotic Fractures', 'Registries', 'Risk Assessment'] | 29,038,836 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A02.835.232.043.150.510'], ['E05.355'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['A02.835.583.411'], ['B01.050.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Special Issue Editors' Essay. | BACKGROUND: Impact evaluations draw their data from two sources, namely, surveys conducted for the evaluation or administrative data collected for other purposes. Both types of data have been used to estimate program impacts. This is an introductory essay to a Special Issue entitled "Do the Estimated Effects of Social ... | ['Humans', 'Models, Statistical', 'Organization and Administration', 'Organizational Policy', 'Program Evaluation', 'Surveys and Questionnaires'] | 31,757,184 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['N04.452'], ['I01.655.500.550', 'I01.880.604.825.550', 'N03.623.500.550'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.9... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress. | Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of severe gastroenteritis in cattle. To gain a better understanding of MAP virulence, we investigated the role of leuD gene in MAP metabolism and stress response. For this, we have constructed an auxotrophic strain of MAP by deleting the leuD gene... | ['Bacterial Proteins', 'Biosynthetic Pathways', 'Environment', 'Esters', 'Fatty Acids', 'Gene Deletion', 'Gene Expression Profiling', 'Gene Expression Regulation, Bacterial', 'Gene Regulatory Networks', 'Genes, Bacterial', 'Hydro-Lyases', 'Mutation', 'Mycobacterium avium subsp. paratuberculosis', 'Phenotype', 'Stress, ... | 22,675,497 | [['D12.776.097'], ['G02.111.098', 'G03.493.100'], ['G16.500.275', 'N06.230'], ['D02.241.400'], ['D10.251'], ['G05.365.590.762.320', 'G05.558.800.320'], ['E05.393.332'], ['G05.308.300'], ['G05.360.080.689.360'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D08.811.520.241.300'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hypernatremia in the aging: causes, manifestations, and outcome. | The incidence, clinical manifestations, morbidity, and mortality of all adult hypernatremic patients hospitalized during a 6-month period were studied. The impact of age on this parameter was evaluated, and the velocity of correction that produced best clinical results was established. Records of all patients who were ... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Aging', 'Female', 'Humans', 'Hypernatremia', 'Incidence', 'Male', 'Middle Aged', 'Prognosis', 'Risk Factors', 'Sex Distribution'] | 7,731,073 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.950.452'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Foreign bodies of the hard palate. | Foreign bodies of the hard palate are rare occurrences with only 11 reported cases in the literature. These patients can present to the Otolaryngologist in a variety of ways and often with confusing histories. We present seven cases of foreign bodies adherent to the hard palate. The age range was three to eighteen mont... | ['Diagnosis, Differential', 'Female', 'Foreign Bodies', 'Humans', 'Infant', 'Male', 'Melanoma', 'Palatal Neoplasms', 'Palate'] | 9,596,367 | [['E01.171'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['C04.588.149.721.450.692', 'C04.588.443.591.692', 'C05.116.231.754.450.692', 'C05.500.499.692', 'C07.320.515.692', 'C07.465.530.692'], ['A14.521.658', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages via anti-inflammatory heme oxygenase-1 induction and inhibition of nuclear factor-êB and signal transducer and activator of transcription 1 activation. | BACKGROUND AND OBJECTIVE: Interleukin-6 (IL-6) is a key proinflammatory cytokine that has been considered to be important in the pathogenesis of periodontal disease. Therefore, host-modulatory agents directed at inhibiting IL-6 appear to be beneficial in terms of attenuating periodontal disease progression and potentia... | ['Animals', 'Anti-Inflammatory Agents', 'Antioxidants', 'Cell Line', 'Down-Regulation', 'Enzyme Induction', 'Enzyme Inhibitors', 'Heme Oxygenase-1', 'I-kappa B Proteins', 'Interleukin-6', 'JNK Mitogen-Activated Protein Kinases', 'Lipopolysaccharides', 'Macrophages', 'Membrane Proteins', 'Metalloporphyrins', 'Mice', 'NF... | 23,441,850 | [['B01.050'], ['D27.505.954.158'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A11.251.210'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.320.200'], ['D27.505.519.389'], ['D08.811.682.690.708.410.500'], ['D12.644.360.365', 'D12.776.260.420', 'D12.776.476.381', 'D12.776.930.326'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Surgical approach to the shoulder. Lesser tuberosity osteotomy]. | Osteotomy of the lesser tuberosity for the surgical delto-pectoral approach to the glenohumeral joint results in good visualization and overview and sufficient anatomical refixation of the insertion of the subscapularis muscle. However, clinical and biomechanical studies have not shown clearly significantly better resu... | ['Arthroplasty, Replacement', 'Humans', 'Osteotomy', 'Shoulder', 'Shoulder Dislocation', 'Shoulder Fractures'] | 23,604,070 | [['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.580'], ['A01.378.800.750'], ['C05.550.518.750', 'C26.289.750', 'C26.803.125'], ['C26.404.625', 'C26.803.250']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An innovative technique for recording picture-in-picture ultrasound videos. | Many ultrasound educational products and ultrasound researchers present diagnostic and interventional ultrasound information using picture-in-picture videos, which simultaneously show the ultrasound image and transducer and patient positions. Traditional techniques for creating picture-in-picture videos are expensive, ... | ['Computer Graphics', 'Computer-Assisted Instruction', 'Computers, Handheld', 'Data Display', 'Equipment Design', 'Equipment Failure Analysis', 'Information Storage and Retrieval', 'Software', 'Ultrasonography', 'Video Recording'] | 23,887,962 | [['L01.224.108', 'L01.296.110'], ['I02.903.771.500.208'], ['L01.224.230.260.550.500'], ['F02.784.412.221', 'L01.296'], ['E05.320'], ['E05.325.192'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.900'], ['E01.370.350.850'], ['L01.280.960']] | ['Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. | The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a long-standing puzzle in immunology. Recently it has become clear that production of immunoglobulin mu heavy chain and subsequent assembly with a surrogate light chain to form the pre-B cell receptor complex is critica... | ['Animals', 'B-Lymphocyte Subsets', 'Bone Marrow Cells', 'Cell Differentiation', 'Cells, Cultured', 'Fetus', 'Gene Expression Regulation, Developmental', 'Humans', 'Immunoglobulin Heavy Chains', 'Immunoglobulin mu-Chains', 'Liver', 'Mice', 'Mice, Transgenic', 'Precipitin Tests', 'Receptors, Antigen, B-Cell', 'Stem Cell... | 9,432,984 | [['B01.050'], ['A11.063.438.450', 'A11.118.637.555.567.550.450', 'A11.118.637.555.567.562.200', 'A15.145.229.637.555.567.550.450', 'A15.145.229.637.555.567.562.200', 'A15.382.032.438.450', 'A15.382.490.555.567.550.300', 'A15.382.490.555.567.562.450'], ['A11.148', 'A15.378.316'], ['G04.152'], ['A11.251'], ['A16.378'], [... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. | To identify novel causes of hereditary thrombocytopenia, we performed a genetic association analysis of whole-genome sequencing data from 13 037 individuals enrolled in the National Institute for Health Research (NIHR) BioResource, including 233 cases with isolated thrombocytopenia. We found an association between rare... | ['Blood Platelets', 'Chromatin', 'Cytoplasmic Granules', 'Female', 'Gene Expression Regulation', 'Genetic Diseases, Inborn', 'Germ-Line Mutation', 'HEK293 Cells', 'Humans', 'Ikaros Transcription Factor', 'Male', 'Mutation, Missense', 'Thrombocytopenia', 'Thrombopoiesis'] | 31,217,188 | [['A11.118.188', 'A15.145.229.188'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['G05.308'], ['C16.320'], ['G05.365.590.350'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D1... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nighttime blood pressure fall in renal disease patients. | OBJECTIVE: There are controversial reports in the prevalence of abnormal nighttime blood pressure fall in renal patients. It has been evaluated nocturnal BP in renal patients using 24 h blood pressure monitoring (ABPM) in comparison with nontreated control subjects either normotensives or hypertensives.DESIGN AND METHO... | ['Adult', 'Antihypertensive Agents', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Chronobiology Disorders', 'Circadian Rhythm', 'Female', 'Humans', 'Hypertension', 'Kidney Diseases', 'Male', 'Middle Aged', 'Sleep'] | 14,575,290 | [['M01.060.116'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['C10.281'], ['G07.180.562.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C12.777.419', 'C13.351.968.419'], ['M01.060.116.630'], ['F02.830.855', 'G11.561.803... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Customer satisfaction and self-reported treatment outcomes among psychiatric inpatients. | OBJECTIVE: Relationships among different dimensions of patient satisfaction and selected demographic, clinical, and outcome variables were explored in a sample of severely ill people receiving inpatient psychiatric services.METHOD: The sample consisted of 81 patients admitted to and discharged from an inpatient psychia... | ['Attitude to Health', 'Chi-Square Distribution', 'Diagnosis-Related Groups', 'Disabled Persons', 'Discriminant Analysis', 'Female', 'Hospitals, Veterans', 'Humans', 'Inpatients', 'Length of Stay', 'Likelihood Functions', 'Male', 'Mental Disorders', 'Middle Aged', 'Midwestern United States', 'Outcome Assessment, Health... | 9,661,228 | [['F01.100.150', 'N05.300.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N03.219.521.710.305.200.080'], ['M01.150'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['N02.278.421.510.180.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humani... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Role of macrophage secretions on rat polycystic ovary: its effect on apoptosis. | Polycystic ovarian syndrome is the most common endocrine disorder among women of reproductive age. Little is known about its etiology, although the evidence suggests an intrinsic ovarian abnormality in which endocrine, metabolic, neural and immune factors would be involved. In this work, the effects of macrophage (MO) ... | ['Androstenedione', 'Animals', 'Apoptosis', 'Blotting, Western', 'Cell Proliferation', 'Cells, Cultured', 'Contraceptive Agents', 'Dinoprostone', 'Disease Models, Animal', 'Estradiol', 'Female', 'Immunoenzyme Techniques', 'Macrophages', 'Nitric Oxide', 'Nitric Oxide Synthase Type II', 'Polycystic Ovary Syndrome', 'Prot... | 26,264,225 | [['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D27.505.696.875.360', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of solubilizers in preclinical formulations: Effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds. | The aim of the present study was to determine whether Cremophor EL is a suitable surfactant that can be routinely applied to pharmacokinetic (PK) studies in early drug discovery without influencing the intrinsic PK characteristics of the new chemical entities (NCEs). Cremophor EL, a polyoxyl 35 castor oil, has been use... | ['Administration, Topical', 'Animals', 'Chemistry, Pharmaceutical', 'Drug Evaluation, Preclinical', 'Glycerol', 'Half-Life', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Pharmaceutical Preparations', 'Rats', 'Rats, Sprague-Dawley', 'Solvents'] | 26,499,309 | [['E02.319.267.120'], ['B01.050'], ['H01.158.703.007', 'H01.181.466'], ['E05.290.750', 'E05.337.550'], ['D02.033.800.875.500', 'D09.853.875.500'], ['G01.910.405'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['D26'], ['B01.050.150.900.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. | The phenotypic actions of the oligotriche gene mutation on testicular function have not been elucidated, although it is known that male mice homozygous for the mutation are infertile. In the present study, the effect of the oligotriche gene mutation on mouse testicular function was analyzed by comparing normal and muta... | ['Animals', 'Homozygote', 'Male', 'Mice', 'Mice, Quaking', 'Microscopy, Electron', 'Mutation', 'Oligospermia', 'Phenotype', 'Spermatogenesis', 'Spermatozoa', 'Testis', 'Testosterone'] | 1,399,832 | [['B01.050'], ['G05.380.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.560'], ['E01.370.350.515.402', 'E05.595.402'], ['G05.365.590'], ['C12.294.365.700.508'], ['G05.695'], ['G04.152.650.624', 'G08.686.784.310.760'], ['A05.360.490.890', 'A11.497.760'], ['A05.360.444.84... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Main alkaloids from the Brazilian dendrobatidae frog Epipedobates flavopictus: pumiliotoxin 251D, histrionicotoxin and decahydroquinolines. | Epipedobates flavopictus, Dendrobatidae, is a small aposematic frog found in Brazilian Cerrado bioma. In the present work, we isolated and characterized chemically the most abundant alkaloids present in the cutaneous extract of E. flavopictus. The specimens were collected in Piren?polis (Goi?s, Brazil), their skins wer... | ['Alkaloids', 'Amphibian Venoms', 'Animals', 'Anura', 'Chromatography, Gas', 'Chromatography, High Pressure Liquid', 'Guinea Pigs', 'Ileum', 'Lethal Dose 50', 'Male', 'Mass Spectrometry', 'Mice', 'Muscle Contraction', 'Sciatic Nerve', 'Skin'] | 15,033,329 | [['D03.132'], ['D20.888.033', 'D23.946.833.033'], ['B01.050'], ['B01.050.150.900.090.180'], ['E05.196.181.349'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.992.550'], ['A03.556.124.684.249', 'A03.556.249.124'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['E05.196.566'], ['B01.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serologic screening for Trypanosoma cruzi among blood donors in central Brazil. | The study reported here compares results obtained by blood banks screening sera for chagasic (Trypanosoma cruzi) infection with results obtained by the Chagas' Disease Reference Laboratory of the Federal University of Goi?s in Goi?nia, Brazil. It also evaluates results obtained using the ELISA technique to screen the s... | ['Adult', 'Blood Banks', 'Blood Donors', 'Brazil', 'Chagas Disease', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fluorescent Antibody Technique', 'Hemagglutination Tests', 'Humans', 'Male', 'Mass Screening', 'Prevalence', 'Sensitivity and Specificity', 'Seroepidemiologic Studies'] | 1,638,280 | [['M01.060.116'], ['N02.278.065.200'], ['M01.898.313'], ['Z01.107.757.176'], ['C01.610.752.300.900.200', 'C01.920.625'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.51... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Diffuse pulmonary alveolar hemorrhage after bone marrow transplantation: radiographic findings in 39 patients. | Diffuse alveolar hemorrhage is a life-threatening complication after bone marrow transplantation. We investigated the radiographic abnormalities that occurred in 39 transplantation patients with a diagnosis of diffuse alveolar hemorrhage and correlated the findings with the patients' clinical course. The initial radiog... | ['Adolescent', 'Adult', 'Aged', 'Bone Marrow Transplantation', 'Female', 'Hemorrhage', 'Humans', 'Lung Diseases', 'Male', 'Middle Aged', 'Prognosis', 'Pulmonary Alveoli', 'Radiography, Thoracic', 'Survival Rate'] | 1,872,226 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.095.147.725.040', 'E04.936.580.040'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['M01.060.116.630'], ['E01.789'], ['A04.411.715'], ['E01.370.350.700.730'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accumulation, activity and localization of cell cycle regulatory proteins and the chloroplast division protein FtsZ in the alga Scenedesmus quadricauda under inhibition of nuclear DNA replication. | Synchronized cultures of the green alga Scenedesmus quadricauda were grown in the absence (untreated cultures) or in the presence (FdUrd-treated cultures) of 5-fluorodeoxyuridine, the specific inhibitor of nuclear DNA replication. The attainment of commitment points, at which the cells become committed to nuclear DNA r... | ['Algal Proteins', 'Amino Acid Sequence', 'Cell Cycle', 'Cell Cycle Proteins', 'Chloroplasts', 'Cyclin B', 'DNA Replication', 'DNA, Algal', 'Floxuridine', 'Molecular Sequence Data', 'Protein Kinases', 'Scenedesmus'] | 18,977,763 | [['D12.776.037'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G04.144'], ['D12.776.167'], ['A11.284.430.214.190.875.700.140'], ['D12.644.360.262.120', 'D12.776.167.218.120', 'D12.776.476.262.120'], ['G02.111.225', 'G05.226'], ['D13.444.308.148'], ['D03.383.742.680.852.300.350', 'D13.570.230.430.432', 'D13.570.685.852... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Production optimization, characterization and gene expression of pullulan from a new strain of Aureobasidium pullulans. | In this study, a new yeast-like fungal was obtained from leaf surfaces collected from Kheyroodkenar forest, Mazandaran, Iran. The properties of this strain, such as morphology, DNA molecular, and product showed that it is related to Aureobasidium pullulans family and named A. pullulans MG271838. The pullulan production... | ['Ascomycota', 'Carbon', 'Fermentation', 'Gene Expression', 'Glucans', 'Nitrogen', 'Phylogeny', 'Spectrum Analysis'] | 31,340,178 | [['B01.300.107'], ['D01.268.150'], ['G02.111.158.249', 'G03.191.249'], ['G05.297'], ['D05.750.078.562', 'D09.698.365'], ['D01.268.604', 'D01.362.625'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.196.867']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia. | Recruitment of neutrophils from blood vessels to sites of infection represents one of the most important elements of innate immunity. Movement of neutrophils across blood vessel walls to the site of infection first requires that the migrating cells firmly attach to the endothelial wall. Generally, neutrophil extravasat... | ['Animals', 'Antigens, Differentiation', 'Bronchoalveolar Lavage Fluid', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Cell Line', 'Cells, Cultured', 'Endothelium, Vascular', 'Escherichia coli Infections', 'Female', 'Galectin 3', 'Humans', 'Kinetics', 'Lung', 'Macrophages, Alveolar', 'Mice', 'Mice, Inbred BALB C', 'Mice... | 11,823,514 | [['B01.050'], ['D23.050.301.264', 'D23.101.100'], ['E05.927.100.500'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['A11.251.210'], ['A11.251'], ['A07.015.700.500', 'A10.272.491.355'], ['C01.150.252.400.310.330'], ['D12.776.503.307.300'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of Study Design and Survey Instrument to Identify the Association Between Depressive Symptoms and Physical Activity in Type 2 Diabetes, 2000-2018: A Systematic Review. | INTRODUCTION: Previous studies have used a variety of survey measurement options for evaluating the association between physical activity (PA) and depressive symptoms, raising questions about the types of instruments and their effect on the association. This study aimed to identify measures of PA and depressive symptom... | ['Adult', 'Aged', 'Depression', 'Diabetes Mellitus, Type 2', 'Exercise', 'Female', 'Humans', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Research Design', 'Surveys and Questionnaires'] | 31,874,591 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.126.350'], ['C18.452.394.750.149', 'C19.246.300'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.581.500', 'H01.770.644.728... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression. | BACKGROUND: Cancer lethality is mainly caused by metastasis. Therefore, understanding the nature of the genes involved in this process has become a priority. BACH1, a basic leucine zipper transcription factor, has been shown to transcriptionally regulate expression of a range of genes that are associated with breast ca... | ['Basic-Leucine Zipper Transcription Factors', 'Cell Movement', 'Gene Expression Regulation, Neoplastic', 'Gene Silencing', 'Humans', 'Male', 'Neoplasm Invasiveness', 'Neoplasm Metastasis', 'Prostatic Neoplasms', 'RNA, Messenger', 'RNA, Small Interfering'] | 28,889,753 | [['D12.776.260.108', 'D12.776.930.127'], ['G04.198', 'G07.568.500.180'], ['G05.308.370'], ['G05.308.203.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.645', 'C23.550.727.645'], ['C04.697.650', 'C23.550.727.650'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D13.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Medical aspects of quality assurance in brachytherapy. | Brachytherapy is a special treatment method which should be performed by experienced teams. The indication of a brachytherapy treatment should follow national and international standards, which are usually result of consensus meetings. Treatment planning requires the definition of various volumes. Different imaging met... | ['Brachytherapy', 'Humans', 'Magnetic Resonance Imaging', 'Quality Assurance, Health Care', 'Radiotherapy Planning, Computer-Assisted', 'Tomography, X-Ray Computed'] | 9,810,339 | [['E02.815.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['N04.761.700', 'N05.700'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Ensuring care quality at a time of diminishing resources. | John Tingle, Reader in Health Law at Nottingham Trent University, discusses the Care Quality Commission's State of Health Care report, in the light of some important clinical negligence trends and reports on major safety failures. | ['Awards and Prizes', "Nurse's Role", 'Quality of Health Care'] | 28,079,425 | [['K01.150'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['N04.761', 'N05.715']] | ['Humanities [K]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An efficient oxidizing reagent for the synthesis of mixed backbone oligonucleotides via the H-phosphonate approach. | The mixture of carbon tetrachloride, N-methyl morpholine (NMM), pyridine and water in acetonitrile has been exploited for the oxidation of dinucleoside H-phosphonate diesters to the corresponding phosphates. The system is found to be inert to the phosphoramidate (P-N) and the phosphorothioate (P-S) linkages and has suc... | ['Chromatography, High Pressure Liquid', 'Indicators and Reagents', 'Magnetic Resonance Spectroscopy', 'Oligonucleotides', 'Organophosphonates', 'Oxidants', 'Oxidation-Reduction', 'Spectrometry, Mass, Electrospray Ionization'] | 12,628,668 | [['E05.196.181.400.300'], ['D27.720.470.410'], ['E05.196.867.519'], ['D13.695.578.424'], ['D02.705.429'], ['D27.720.642', 'D27.888.569.540'], ['G02.700', 'G03.295.531'], ['E05.196.566.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of melanogenesis by human uveal melanocytes in vitro. | The purpose of this study was to investigate factors regulating melanogenesis in cultured human uveal melanocytes. The effects of various substances on the melanin content, tyrosinase activity and growth of cultured uveal melanocytes were tested. 12-O-tetradecanoyl-phorbol-13-acetate (a protein kinase C activator) and ... | ['Adult', 'Bucladesine', 'Cells, Cultured', 'Cholera Toxin', 'Cyclic AMP', 'Dose-Response Relationship, Drug', 'Fibroblast Growth Factor 2', 'Humans', 'Melanins', 'Melanocytes', 'Monophenol Monooxygenase', 'Tetradecanoylphorbol Acetate', 'Uvea'] | 9,196,391 | [['M01.060.116'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['A11.251'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['G07.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cry features in siblings of SIDS. | AIM: To examine the acoustic features of crying demonstrated by infants whose older sibling died of sudden infant death syndrome (SIDS) and compare these features to a nonrisk group of infants.METHODS: Pain-induced crying episodes were collected from a group of healthy term (HT) infants and siblings of SIDS infants. On... | ['Acoustics', 'Communication', 'Crying', 'Epidemiologic Studies', 'Female', 'Health Status', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'New Zealand', 'Parent-Child Relations', 'Pilot Projects', 'Risk Factors', 'Siblings', 'Sudden Infant Death'] | 17,880,413 | [['H01.671.031'], ['F01.145.209', 'L01.143'], ['F01.145.209.530.258', 'F01.525.200.310.300'], ['E05.318.372.500', 'N05.715.360.330.500', 'N06.850.520.450.500'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['Z01.639.760.747... | ['Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Fatty acid beta-oxidation system in microbodies of n-alkane-grown Candida tropicalis. | Localization of fatty acid beta-oxidation system in microbodies of Candida tropicalis cells growing on n-alkanes was studied. Microbodies isolated from the yeast cells showed palmitate-dependent activities of NAD reduction, acetyl-CoA formation and oxygen consumption. When sodium azide, an inhibitor of catalase, was ad... | ['Acetyl Coenzyme A', 'Alkanes', 'Candida', 'Catalase', 'Electron Transport Complex IV', 'Fatty Acids', 'Kinetics', 'Microbodies', 'NAD'] | 204,485 | [['D03.633.100.759.646.138.382.300.020', 'D08.211.211.300.075', 'D13.695.667.138.382.300.020', 'D13.695.827.068.382.300.020'], ['D02.455.326.146'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D08.811.682.732.332'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expulsion of an intraocular lens through a clear corneal wound. | A 91-year-old man sustained blunt trauma to an eye that had uneventful phacoemulsification through a superior clear corneal incision 5 years earlier. The silicone foldable intraocular lens (IOL) and a portion of the iris and capsular bag were expulsed through the cataract excision, which then self-sealed. This case ill... | ['Accidental Falls', 'Aged', 'Aged, 80 and over', 'Cornea', 'Corneal Injuries', 'Eye Injuries', 'Humans', 'Iris Diseases', 'Lens Capsule, Crystalline', 'Lens Implantation, Intraocular', 'Lenses, Intraocular', 'Male', 'Phacoemulsification', 'Prolapse', 'Silicone Elastomers', 'Surgical Wound Dehiscence', 'Wounds, Nonpene... | 12,663,029 | [['N06.850.135.122'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A09.371.060.217'], ['C10.900.300.284.250.124', 'C11.204.284', 'C11.297.374', 'C26.915.300.425.250.124'], ['C10.900.300.284.250', 'C11.297', 'C26.915.300.425.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.941.375'], ['A09.371.060.500.15... | ['Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Peritubular capillary injury during the progression of experimental glomerulonephritis in rats. | The functional and morphologic changes occurring in the peritubular capillaries (PTC) of the kidney during the progression of renal disease are not yet completely understood. In this study, the features of PTC disruption observed in a rat anti-glomerular basement membrane-induced glomerulonephritis (GN) model were char... | ['Animals', 'Capillaries', 'Cell Death', 'Disease Models, Animal', 'Disease Progression', 'Glomerulonephritis', 'Kidney Function Tests', 'Kidney Tubules', 'Male', 'Rats', 'Rats, Inbred WKY', 'Statistics, Nonparametric'] | 10,616,839 | [['B01.050'], ['A07.015.461.165'], ['G04.146'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['E01.370.390.400'], ['A05.810.453.736.560'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.390', 'B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes. | The subject of this report was to investigate headgroup hydration and mobility of two types of mixed lipid vesicles, containing nonionic surfactants; straight chain Brij 98, and polysorbat Tween 80, with the same number of oxyethylene units as Brij, but attached via a sorbitan ring to oleic acid. We used the fluorescen... | ['2-Naphthylamine', 'Animals', 'Chemistry Techniques, Analytical', 'Fluorescent Dyes', 'Laurates', 'Lipid Bilayers', 'Melitten', 'Palmitic Acids', 'Phosphatidylcholines', 'Plant Oils', 'Polyethylene Glycols', 'Polysorbates', 'Protein Binding', 'Solvents', 'Spectrometry, Fluorescence', 'Surface-Active Agents', 'Time Fac... | 17,300,743 | [['D02.092.710', 'D02.455.426.559.847.638.850', 'D04.615.638.850'], ['B01.050'], ['E05.196'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D10.251.500.410'], ['D10.570.510', 'J01.637.087.500.510'], ['D12.644.050.550', 'D12.776.543.695.054.550', 'D20.888.065.115.580', 'D23.946.833.065.115.580'], ['D10.251.694'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Crohn's Disease Patients in Remission Display an Enhanced Intestinal IgM⁺ B Cell Count in Concert with a Strong Activation of the Intestinal Complement System. | Inflammatory bowel disease (IBD) is an umbrella term that comprises Crohn's disease (CD) and ulcerative colitis (UC). Both entities are characterized by a disturbed mucosal immune response and an imbalance of intestinal microbiota composition. The complement system (C) plays a critical role in the detection, and cleara... | ['B-Lymphocytes', 'Complement Activation', 'Complement System Proteins', 'Crohn Disease', 'Feces', 'Female', 'Humans', 'Immunoglobulin M', 'Immunologic Memory', 'Intestinal Mucosa', 'Intestines', 'Lymphocyte Count', 'Male', 'Models, Immunological', 'Remission Induction', 'Up-Regulation'] | 30,669,641 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G12.274'], ['D12.776.124.486.274'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.7... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relationship between airway microvascular leakage, edema, and baseline airway functions. | This study was designed to examine the relationship among microvascular leakage, edema, and baseline airway function. Microvascular leakage was induced in the airways of anesthetized, tracheostomized New Zealand White rabbits (n = 22) by using nebulized N-formyl-methionyl-leucyl-phenylalanine (10 mg) and was measured i... | ['Air Pressure', 'Animals', 'Blood Pressure', 'Blood-Air Barrier', 'Capillary Permeability', 'Lung Volume Measurements', 'Male', 'N-Formylmethionine Leucyl-Phenylalanine', 'Pulmonary Edema', 'Rabbits', 'Respiratory Function Tests', 'Respiratory Mechanics'] | 9,451,620 | [['G16.500.750.274.100', 'N06.230.300.100.185.100'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A04.411.715.200', 'A07.020'], ['G03.143.330', 'G09.330.165'], ['E01.370.386.700.485'], ['D02.886.030.676.450.440', 'D12.125.072.050.685.445', 'D12.125.142.666.500', 'D12.125.166.676.450.440', 'D12.644.456.400... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Hospital treatment of child-tourists at the Pula Medical Center 1983-1988]. | During the 6-year period, 687 children-tourists, aged up to 12 years, were treated at the departments of the Medical Center of Pula; on average 114.5 (standard deviation +/- 17.79) children per year. There were 449 (65.4%) patients from different parts of Yugoslavia and 238 (24.6%) from abroad. Two hundred and fifty-fo... | ['Child', 'Child, Preschool', 'Female', 'Hospitals', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Travel', 'Yugoslavia'] | 2,097,479 | [['M01.060.406'], ['M01.060.406.448'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['I03.883'], ['Z01.586.980']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Competitive PCR quantification of CD4, CD8, ICAM-1, VCAM-1, and MHC class II mRNA in the central nervous system during development and resolution of experimental allergic encephalomyelitis. | We used competitive polymerase chain reaction to quantify messenger RNA for the lymphocyte antigens CD4 and CD8, the adhesion molecules ICAM-1 and VCAM-1, and the MHC class II I-A molecule in the spinal cords of SJL/J mice at multiple times during the development and resolution of experimental allergic encephalomyeliti... | ['Animals', 'CD4 Antigens', 'CD8 Antigens', 'Cell Adhesion Molecules', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Histocompatibility Antigens Class II', 'Intercellular Adhesion Molecule-1', 'Mice', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Vascular Cell Adhesion Molecule-1'] | 7,693,755 | [['B01.050'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['D23.050.301.264.894.108', 'D23.101.100.894.108'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Application of next-generation sequencing technology for genetic diagnosis of Duchenne muscular dystrophy]. | OBJECTIVE: To detect genetic causes of Duchenne muscular dystrophy (DMD).METHODS: Next-generation sequencing was used to detect 6 DMD patients in whom no exonic deletions were detected by multiplex PCR. Sanger sequencing and multiplex ligation-dependent probe amplification were used to confirm the results.RESULTS: One ... | ['Adolescent', 'Base Sequence', 'Child', 'Genetic Variation', 'Humans', 'Infant', 'Molecular Sequence Data', 'Muscular Dystrophy, Duchenne', 'Sequence Analysis, DNA'] | 22,678,781 | [['M01.060.057'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['M01.060.406'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['L01.453.245.667'], ['C05.651.534.500.300', 'C10.668.491.175.500.300', 'C16.320.322.562', 'C16.320.577.300'], ['E05.393.760.700']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
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