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Analysis of sequence-specific binding of RNA to Hsp70 and its various homologs indicates the involvement of N- and C-terminal interactions. | Members of the 70-kDa family of molecular chaperones assist in a number of molecular interactions that are essential under both normal and stress conditions. These functions require ATP and co-chaperone molecules and are associated with a cyclic transition of intramolecular conformational changes. As a new putative fun... | ['Adenosine Triphosphatases', 'Bacterial Proteins', 'Binding Sites', 'Carrier Proteins', 'Conserved Sequence', 'Escherichia coli Proteins', 'HSP40 Heat-Shock Proteins', 'HSP70 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Humans', 'Molecular Chaperones', 'RNA', 'RNA-Binding Proteins'] | 11,720,291 | [['D08.811.277.040.025'], ['D12.776.097'], ['G02.111.570.120'], ['D12.776.157'], ['G02.111.570.580'], ['D12.776.097.275'], ['D12.776.580.216.292'], ['D12.776.580.216.375'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.580'], ['D13.444.735'], ['D12.776.157.725', 'D12.776.664.962']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accessory limb production by nerve-induced cell proliferation. | The deviation of large limb nerves to a more proximal skin wound yielded a high proportion of accessory limb responses in different age groups of Ambystoma mexicanum (axolotls). In some instances the deviated nerve was positioned on skin previously grafted from an animal of different age and pigmentation from that of t... | ['Ambystoma', 'Ambystoma mexicanum', 'Animals', 'Cell Division', 'Extremities', 'Microscopy, Electron', 'Nerve Fibers', 'Regeneration', 'Schwann Cells', 'Skin Transplantation', 'Wound Healing'] | 3,291,642 | [['B01.050.150.900.090.608.080.068'], ['B01.050.150.900.090.608.080.068.525'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A01.378'], ['E01.370.350.515.402', 'E05.595.402'], ['A08.675.542', 'A11.671.501'], ['G16.762'], ['A08.637.800', 'A08.800.800.690', 'A11.650.800'], ['E02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical features and treatment of hereditary hemorrhagic telangiectasia. | Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disorder characterized by vascular dysplasia, including typically systemic telangiectases and arteriovenous malformations (AVMs). Due to its variable clinical manifestations, HHT patients often seek medical care from different medical subspecialti... | ['Adult', 'Angiogenesis Inhibitors', 'Arteriovenous Malformations', 'Delayed Diagnosis', 'Epistaxis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Mouth Mucosa', 'Telangiectasia, Hereditary Hemorrhagic', 'Telangiectasis', 'Thalidomide'] | 30,075,565 | [['M01.060.116'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['C14.240.850.750', 'C14.907.150', 'C16.131.240.850.750'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.040'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A complex network of RNA-RNA interactions controls subgenomic mRNA transcription in a tombusvirus. | Eukaryotic (+)-strand RNA viruses utilize a wide variety of gene expression strategies to achieve regulated production of their viral proteins. A common mechanism used by many is to transcribe viral subgenomic (sg) mRNAs. Transcription of sg mRNA2 in tombusviruses allows for expression of the p19 suppressor of gene sil... | ['Base Pairing', 'Base Sequence', 'Down-Regulation', 'Gene Expression Regulation, Viral', 'Genetic Engineering', 'Genome, Viral', 'Molecular Sequence Data', 'Promoter Regions, Genetic', 'RNA Stability', 'RNA, Messenger', 'RNA, Viral', 'Tombusvirus', 'Transcription, Genetic', 'Virus Replication'] | 15,282,544 | [['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.385'], ['E05.393.420'], ['G05.360.340.358.840'], ['L01.453.245.667'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.34... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D. | The endosomal compartment of hepatic parenchymal cells contains an acidic endopeptidase, endosomal acidic insulinase, which hydrolyzes internalized insulin and generates the major primary end product A(1--21)-B(1--24) insulin resulting from a major cleavage at residues Phe(B24)-Phe(B25). This study addresses the nature... | ['Amyloid Precursor Protein Secretases', 'Animals', 'Aspartic Acid Endopeptidases', 'Catalysis', 'Cathepsin D', 'Endopeptidases', 'Endosomes', 'Insulin', 'Male', 'Pepstatins', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Insulin', 'Transport Vesicles'] | 11,779,865 | [['D08.811.277.656.300.032'], ['B01.050'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['G02.130'], ['D08.811.277.656.074.500.180', 'D08.811.277.656.224.187', 'D08.811.277.656.300.048.180'], ['D08.811.277.656.300'], ['A11.284.430.214.190.875.190.880.337'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.20... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical role of albumin to globulin ratio in microscopic polyangiitis: a retrospective monocentric study. | We investigated whether albumin to globulin ratio (AGR) at diagnosis may be associated with all-cause mortality in immunosuppressive drug-na?ve patients with microscopic polyangiitis (MPA). We retrospectively reviewed the medical records of 88 MPA patients, who were first classified and in whom medications was first in... | ['Adult', 'Aged', 'Female', 'Humans', 'Male', 'Microscopic Polyangiitis', 'Middle Aged', 'Proportional Hazards Models', 'Republic of Korea', 'Retrospective Studies', 'Serum Albumin', 'Serum Globulins'] | 30,218,289 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.275.600', 'C14.907.253.329.600', 'C14.907.940.897.249.500', 'C20.111.193.750'], ['M01.060.116.630'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.998.825', 'E05.599.835.900', '... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Surgical complications of multichannel cochlear implants in North America. | By paying careful attention to the details of surgical technique, many of the complications which have occurred to date may be avoided. Some, such as late electrode and receiver/stimulator migration, device failures, and late flap necrosis due to excessive magnetic forces cannot be avoided by the surgeon, but may be pr... | ['Adult', 'Child', 'Cochlear Implants', 'Humans', 'Postoperative Complications', 'Prosthesis Design', 'Prosthesis Failure', 'Surgical Flaps', 'United States'] | 8,273,503 | [['M01.060.116'], ['M01.060.406'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767'], ['E05.320.550', 'E07.695.680'], ['C23.550.767.865', 'E05.325.771'], ['A10.850.710', 'E07.862.710'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Molecular characterization of extended-spectrum beta-lactamases and its correlation with clinical laboratory standards institute interpretive criteria for disk diffusion susceptibility testing in enterobacteriaceae isolates in Thaialnd. | We performed extended-spectrum beta-lactamase (ESBL) phenotypic testing and molecular characterization of three ESBL genes (TEM, SHV and CTX-M) and susceptibility testing by Clinical Laboratory Standards Institute (CLSI) disk diffusion method against three cephalosporins (ceftriaxone, ceftazidime, cefepime) and a cepha... | ['Anti-Bacterial Agents', 'Cephalosporins', 'Cephamycins', 'Disk Diffusion Antimicrobial Tests', 'Enterobacteriaceae', 'Humans', 'Klebsiella pneumoniae', 'Molecular Medicine', 'Reference Standards', 'Thailand', 'beta-Lactamases'] | 23,413,710 | [['D27.505.954.122.085'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['D02.065.589.099.249.250', 'D02.886.665.074.250', 'D03.633.100.300.249.250'], ['E01.370.225.875.595.399', 'E05.200.875.595.399'], ['B03.440.450.425', 'B03.660.250.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Effects of profound hemodilution on small-intestinal wound healing in rabbits. | BACKGROUND: Wound healing is influenced by tissue oxygen tension and blood perfusion, but not by moderate anemia or hemodilution. The effect of perioperative profound hemodilution on small-intestinal wound healing remains unclear.METHODS: We performed jejunectomy followed by end-to-end anastomosis in rabbits subjected ... | ['Anastomosis, Surgical', 'Animals', 'Blood Transfusion, Autologous', 'Factor XIII', 'Fibrinogen', 'Hemodilution', 'Hemoglobins', 'Hydroxyethyl Starch Derivatives', 'Intestine, Small', 'Jejunum', 'Plasma Substitutes', 'Rabbits', 'Serum Albumin', 'Tensile Strength', 'Wound Healing'] | 11,421,611 | [['E04.035'], ['B01.050'], ['E02.095.135.164'], ['D08.622.505', 'D12.776.124.125.475', 'D12.776.811.243.505', 'D23.119.475'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['E02.514'], ['D12.776.124.400', 'D12.776.422.316.762'], ['D09.301.915.500', 'D09.698.365.855.500'], ['A03.556.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Repeated exposure to one song leads to a rapid and persistent decline in an immediate early gene's response to that song in zebra finch telencephalon. | Conspecific song induces a prompt increase in the expression of the zenk gene in the caudo-medial neostriatum (NCM), a part of the auditory telencephalon of songbirds. To test the hypothesis that zenk gene induction in NCM is related to the acquisition of new song-related memories, we presented adult male zebra finches... | ['Animal Communication', 'Animals', 'Birds', 'Corpus Striatum', 'Gene Expression', 'Genes, Immediate-Early', 'Male', 'RNA, Messenger', 'Time Factors', 'Vocalization, Animal'] | 7,472,448 | [['F01.145.113.055'], ['B01.050'], ['B01.050.150.900.248'], ['A08.186.211.200.885.287.249.487'], ['G05.297'], ['G05.360.340.024.340.330', 'G05.360.340.024.340.364.875.345', 'G05.360.340.358.024.875.345', 'G05.360.340.358.840.500.345'], ['D13.444.735.544'], ['G01.910.857'], ['F01.145.113.055.800']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subcutaneous ovarian tissue transplantation in nonhuman primates: duration of endocrine function and normalcy of subsequent offspring as demonstrated by reproductive competence, oocyte production, and telomere length. | PURPOSE: The main purposes of the study were to investigate the endocrine function of ovarian tissue transplanted to heterotopic subcutaneous sites and the reproductive competence and telomere length of a nonhuman primate originating from transplanted tissue.METHODS: Ovarian cortex pieces were transplanted into the ori... | ['Animals', 'Cryopreservation', 'Estradiol', 'Female', 'Fertility Preservation', 'Macaca mulatta', 'Oocytes', 'Ovarian Follicle', 'Ovary', 'Ovulation Induction', 'Pregnancy', 'Progesterone', 'Reproduction', 'Telomere Homeostasis'] | 28,942,525 | [['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E02.875.800.625', 'E04.936.537.562', 'E05.820.800.625'], ['B01.050.150.900.649.313.988.400.112.199.1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The facial nerve: how to find it. | Iatrogenic facial paralysis is one of the most serious and most dreaded complications of temporal bone surgery. The risk of this complication as well as the duration of surgery can be reduced if the otologic surgeon can promptly identify the facial nerve at any stage of an operation. This is especially important in cas... | ['Cholesteatoma', 'Ear, Middle', 'Facial Nerve', 'Facial Paralysis', 'Female', 'Humans', 'Male', 'Mastoid', 'Temporal Bone', 'Tympanic Membrane'] | 8,269,874 | [['C17.800.428.260'], ['A09.246.397'], ['A08.800.050.050.275', 'A08.800.050.600.149', 'A08.800.800.060.275', 'A08.800.800.120.250'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.885.444'], ['A02.835.232.781.885'], ['A09.246.272.702']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Modified NEWS as a Safe and Inventive Approach for Gastrointestinal Stromal Tumor near the Esophagogastric Junction]. | Laparoscopy and endoscopy cooperative surgery(LECS)is an excellent surgical procedure that utilizes the advantages of both methods. Furthermore, non-exposed endoscopic wall-inversion surgery(NEWS)is a more promising procedure that enables avoidance of tumor exposure of and dissemination to the abdominal cavity. However... | ['Esophagogastric Junction', 'Gastrointestinal Stromal Tumors', 'Humans', 'Laparoscopy', 'Stomach Neoplasms'] | 30,692,315 | [['A03.556.875.500.414', 'A03.556.875.875.330'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3C protein of feline coronavirus inhibits viral replication independently of the autophagy pathway. | Feline coronavirus (FCoV) can cause either asymptomatic enteric infection or fatal peritonitis in cats. Although the mutation of FCoV accessory gene 3c has been suggested to be related to the occurrence of feline infectious peritonitis (FIP), how the 3C protein is involved in this phenomenon remains unknown. To investi... | ['Animals', 'Autophagy', 'Cats', 'Cells, Cultured', 'Coronavirus 3C Proteases', 'Coronavirus, Feline', 'Cysteine Endopeptidases', 'Feline Infectious Peritonitis', 'Female', 'Male', 'Virulence', 'Virus Replication'] | 24,050,534 | [['B01.050'], ['G04.011'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A11.251'], ['D08.811.277.656.262.500.108.500', 'D08.811.277.656.979.250.500', 'D12.776.964.900.500.500.500'], ['B04.820.578.500.540.150.075.500.375'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['C01.925.782.600.550.200.360', 'C2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A note on permutation tests of significance for multiple regression coefficients. | In the vast majority of psychological research utilizing multiple regression analysis, asymptotic probability values are reported. This paper demonstrates that asymptotic estimates of standard errors provided by multiple regression are not always accurate. A resampling permutation procedure is used to estimate the stan... | ['Educational Measurement', 'Humans', 'Psychology', 'Regression Analysis', 'Teaching'] | 17,564,207 | [['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.628'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['I02.903']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Morphology of accessory genital glands of spotted paca (Agouti paca Linnaeus, 1766). | The spotted paca is the second largest rodent in Brazil, where it is of great economic interest in impoverished regions in view of its prominence as a low-cost source of protein. Little is known about the morphology of the accessory genital glands of this species. Thus, we studied the position and morphology of the gen... | ['Animals', 'Bulbourethral Glands', 'Genitalia, Male', 'Male', 'Organ Size', 'Prostate', 'Rodentia', 'Testis', 'Urethra'] | 24,461,579 | [['B01.050'], ['A05.360.444.123', 'A10.336.197'], ['A05.360.444'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['A05.360.444.575', 'A10.336.707'], ['B01.050.150.900.649.313.992'], ['A05.360.444.849', 'A05.360.576.782', 'A06.300.312.782'], ['A05.360.444.492.726', 'A05.810.876']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia. | OBJECTIVE: Patients with myelodysplasia (MDS) show a disturbed production of ROS in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in granulocyte-macrophage colony-stimulating factor (GM-CSF)-primed neutrophils. Because generation of ROS is mediated by the NADPH oxidase complex, a component of which i... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cytochrome b Group', 'Female', 'Gene Expression Regulation, Enzymologic', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Male', 'Middle Aged', 'Myelodysplastic Syndromes', 'N-Formylmethionine Leucyl-Phenylalanine', 'NADPH Oxidases', 'Neutrophil Activation', 'Neutr... | 12,962,720 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.244.187', 'D12.776.422.220.187'], ['G05.308.320'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C15.378.190.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Food allergy in childhood]. | Food allergies can result in life-threatening reactions and diminish quality of life. The prevalence of food allergies has increased in several regions throughout the world. A few food allergens cover the majority of food-related reactions (milk, egg, wheat, soy, fish, crustacean, nuts and peanut). Immunological mechan... | ['Allergens', 'Cross-Sectional Studies', 'Diagnosis, Differential', 'Food Hypersensitivity', 'Humans', 'Immunoglobulin E'] | 23,179,672 | [['D23.050.063'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.171'], ['C20.543.480.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cessation of Ureteral Colic Does Not Necessarily Mean that a Ureteral Stone Has Been Expelled. | PURPOSE: We evaluated whether cessation of renal colic is consistent with an expelled ureteral stone or whether imaging may be indicated even in the absence of symptoms.MATERIALS AND METHODS: We performed a retrospective study of patients who presented to our institution with acute renal colic and ureteral stone, and w... | ['Adult', 'Aged', 'Asymptomatic Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Renal Colic', 'Retrospective Studies', 'Ureter', 'Ureteral Calculi', 'Ureteral Obstruction'] | 29,107,030 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.187'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612.972', 'C23.888.721', 'F02.830.816.444.850', 'G11.561.790.444.850'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.5... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of dietary intake and protease inhibitors on serum vitamin B12 levels in a cohort of human immunodeficiency virus-positive patients. | The dietary intake of micronutrients and serum micronutrient status have been topics of concern in relation to human immunodeficiency virus (HIV) progression. Most data, however, were collected prior to the introduction of protease inhibitors (PIs). We analyzed dietary intake and serum values of vitamin B(12), includin... | ['Adult', 'Cohort Studies', 'Female', 'HIV Infections', 'HIV Protease Inhibitors', 'Humans', 'Male', 'Nutrition Assessment', 'Vitamin B 12'] | 12,942,386 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['D27.505.519.389.745.900.500', 'D27.505.954.122.388.077.088.420'], ['B01.050.150.900.649.313.988.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical Validation of Quality Improvements Using the Six Sigma Concept: A Case Study for Deep Brain Stimulation in Parkinson's Disease. | BACKGROUND: The Six Sigma concept allows for the evaluation of quality changes after the implementation of new technical equipment or adjustment of perioperative procedures. Exemplarily, we applied this method for quality assessment in deep brain stimulation surgery (DBS) for Parkinson's disease.METHODS: The medical pr... | ['Aged', 'Deep Brain Stimulation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Operative Time', 'Parkinson Disease', 'Quality Improvement', 'Reproducibility of Results', 'Subthalamic Nucleus', 'Total Quality Management', 'Treatment Outcome'] | 31,553,992 | [['M01.060.116.100'], ['E02.331.300', 'E04.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['J01.293.754', 'N04.761.744'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Community response to noise in Vietnam: exposure-response relationships based on the community tolerance level. | Social surveys on noise annoyance have been conducted in five different cities in Vietnam. The surveys included both aircraft noise (three airports) and road traffic noise (five cities). The main objective for these studies was to establish dose-response functions that were representative for Vietnam. The results have ... | ['Acoustics', 'Aircraft', 'Automobiles', 'Environmental Exposure', 'Environmental Monitoring', 'Female', 'Humans', 'Interviews as Topic', 'Irritable Mood', 'Male', 'Noise, Transportation', 'Surveys and Questionnaires', 'Urban Health', 'Vibration', 'Vietnam'] | 25,994,692 | [['H01.671.031'], ['J01.937.285.100'], ['J01.937.500.100'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F01.470.047.110'], ['N06.230.400.550', 'N06.850.460.610.68... | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Survival and Safety Outcomes of ICU Patients Discharged Directly Home-A Direct From ICU Sent Home Study. | OBJECTIVES: Evaluate outcomes (mortality, morbidity, unplanned return visits) of patients who are discharged directly to home from the ICU.DESIGN: Prospective cohort study.SETTING: Two tertiary care medical-surgical-trauma ICUs at Canadian hospitals over 1 year (February 2016-2017).SUBJECTS: All adult patients who were... | ['Adult', 'Female', 'Humans', 'Intensive Care Units', 'Male', 'Middle Aged', 'Mortality', 'Patient Discharge', 'Patient Readmission', 'Prospective Studies', 'Survival Analysis', 'Tertiary Care Centers'] | 29,494,475 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['M01.060.116.630'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['E02.760.169.125', 'E02.760.400.610', 'N02.421.585.169.125', 'N02.421.585.400.610', 'N04.590.233.727.210.125'], ... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A case-control study of microenvironmental risk factors for urban visceral leishmaniasis in a large city in Brazil, 1999-2000. | OBJECTIVES: We investigated potential microenvironmental risk factors for visceral leishmaniasis in urban and suburban areas, and developed risk scores to characterize the household and the neighborhood. These scores may be useful to identify microenvironments within cities that place residents at greater risk of visce... | ['Adolescent', 'Adult', 'Brazil', 'Case-Control Studies', 'Environment', 'Female', 'Humans', 'Leishmaniasis, Visceral', 'Male', 'Middle Aged', 'Risk Factors', 'Urban Population'] | 17,341,327 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.300.500.510', 'C01.920.813.510'], ['M01.060.116.630'], ['E05.318.740.600.800.725', 'N05.715.35... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Estimation of rat mammary tumor volume using caliper and ultrasonography measurements. | Mammary tumors similar to those observed in women can be induced in rats by intraperitoneal administration of N-methyl-N-nitrosourea. Determining tumor volume is a useful and quantitative way to monitor tumor progression. In this study, the authors measured dimensions of rat mammary tumors using a caliper and using rea... | ['Animals', 'Female', 'Mammary Neoplasms, Animal', 'Mammary Neoplasms, Experimental', 'Methylnitrosourea', 'Physical Examination', 'Rats', 'Rats, Sprague-Dawley', 'Reproducibility of Results', 'Tumor Burden', 'Ultrasonography'] | 23,689,461 | [['B01.050'], ['C04.588.531', 'C22.520'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ['D02.065.950.594.490', 'D02.654.692.480'], ['E01.370.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.8... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a. Covalent modifications of aspartic acid 191, lysine 155, and the pyruvoyl group. | The pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a is rapidly inactivated by incubation with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and glycine ethyl ester. On 90% of inactivation, 1.3 residues of [14C]glycine ethyl ester are incorporated per alpha subunit; nearly 60% of this is linked to the ... | ['Aspartic Acid', 'Carboxy-Lyases', 'Ethyldimethylaminopropyl Carbodiimide', 'Glycine', 'Histidine Decarboxylase', 'Kinetics', 'Lactobacillus', 'Lysine', 'Pyruvates'] | 3,082,865 | [['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['D08.811.520.224.125'], ['D02.491.203.425'], ['D12.125.481'], ['D08.811.520.224.125.300'], ['G01.374.661', 'G02.111.490'], ['B03.353.750.450.475', 'B03.510.460.400.410.475.475', 'B03.510.550.450.475'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Perioperative administration of recombinant human erythropoietin in colorectal cancer surgery. A prospective, randomized, double-blind placebo controlled study]. | One hundred patients scheduled for elective colo-rectal cancer surgery, and with a preoperative haemoglobin level < or = 8.5 mmol/l were included. Eighty-one patients could be evaluated. Thirty-eight patients received r-HuEPO in a dose of 300 IU/kg body weight on day four before surgery and 150 IU/kg, daily, for the fo... | ['Adult', 'Aged', 'Blood Loss, Surgical', 'Blood Transfusion', 'Colonic Neoplasms', 'Double-Blind Method', 'Erythropoietin', 'Female', 'Hemoglobins', 'Humans', 'Intraoperative Care', 'Male', 'Middle Aged', 'Prospective Studies', 'Recombinant Proteins', 'Rectal Neoplasms', 'Transfusion Reaction'] | 10,680,473 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.414.300', 'C23.550.505.300'], ['E02.095.135'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Flow control technique to prevent distal embolization during mechanical thrombectomy. | In an era of increasing emphasis on minimally invasive surgery, distal embolization remains a concern in the absence of distal flow control. We present a case using an endovascular flow control technique that can be used for reducing distal embolic events during endovascular recanalization of aortoiliac occlusive disea... | ['Adult', 'Embolism', 'Equipment Design', 'Female', 'Humans', 'Regional Blood Flow', 'Thrombectomy'] | 22,975,336 | [['M01.060.116'], ['C14.907.355.350'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.100.780'], ['E04.100.814.842']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Histopathology of cryptococcosis and other fungal infections in patients with acquired immunodeficiency syndrome. | OBJECTIVE: To gain insight into the histopathologic characteristics of fungal infection in acquired immunodeficiency syndrome (AIDS).METHODS: A review was conducted of the histopathology for 162 patients with evident fungal infection.RESULTS: The microscopic appearance of esophageal candidiasis that was common in patie... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Aspergillus', 'Candida', 'Candidiasis', 'Cryptococcosis', 'Cryptococcus', 'Esophagus', 'Giant Cells', 'Histiocytes', 'Humans', 'Immunocompetence', 'Immunohistochemistry', 'Liver', 'Lung Diseases, Fungal', 'Male', 'Middle Aged', 'Mycoses'] | 11,468,102 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['B01.300.381.081'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['C01.150.703.160'], ['C01.150.703.248'], ['B01.300... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Feasability study of screening for malignant lesions in the oral cavity targeting tobacco users]. | INTRODUCTION: Oral cavity cancer is frequent. Prognosis of this cancer is closely linked to the development. Although the oral cavity is a potentially accessible site for examination, up to 50% of oral cancers are not detected until the disease is well advanced.PATIENTS AND METHOD: In a region where incidence rate is p... | ['Adult', 'Aged', 'Feasibility Studies', 'Female', 'France', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Mouth', 'Mouth Neoplasms', 'Pilot Projects', 'Population Surveillance', 'Social Participation', 'Tobacco Industry', 'Tobacco Use Disorder'] | 25,732,896 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]... | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Iterated learning: a framework for the emergence of language. | Language is culturally transmitted. Iterated learning, the process by which the output of one individual's learning becomes the input to other individuals' learning, provides a framework for investigating the cultural evolution of linguistic structure. We present two models, based upon the iterated learning framework, ... | ['Language', 'Learning', 'Neural Networks, Computer'] | 14,761,257 | [['F01.145.209.399', 'L01.559'], ['F02.463.425', 'F02.784.629.529'], ['G17.485', 'L01.224.050.375.605']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Endobronchial hamartoma suspected lung cancer due to false positive of fluorodeoxyglucose-positron emission tomography; report of a case]. | A 63-year-old male was referred to our hospital with an abnormal shadow on chest radiography and computed tomography. A transbronchial lung biopsy did not reveal any malignant lesion. A fluorodeoxyglucose-positron emission tomography (FDG-PET) was done for further examination and it revealed positive. Right upper lobec... | ['Bronchial Diseases', 'Diagnosis, Differential', 'False Positive Reactions', 'Fluorodeoxyglucose F18', 'Hamartoma', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Positron-Emission Tomography', 'Radiopharmaceuticals'] | 19,670,790 | [['C08.127'], ['E01.171'], ['E01.354.506'], ['D09.254.229.500'], ['C04.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.399', 'E01.370.350.825.800.399', 'E01... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. | Twenty-eight patients with myasthenia gravis (MG), five with and 23 without thymoma, and 47 normal controls were typed for serologically defined HLA-A, B, C, and DRw antigens. Sera from all patients were titered for antibodies to acetylcholine receptors (AChR). The frequency of HLA-B8 and DRw3 in the non-thymoma MG pat... | ['Acetylcholine', 'Adolescent', 'Adult', 'Aged', 'Antibodies', 'Epitopes', 'Female', 'Gene Frequency', 'Genes, MHC Class II', 'HLA Antigens', 'Humans', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Receptors, Cholinergic'] | 85,353 | [['D02.092.211.111'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D23.050.550'], ['G05.330'], ['G05.360.340.024.340.610.600', 'G05.360.340.024.380.500.600', 'G12.500.500.600'], ['D23.050.301.500.450', 'D23.050.705.552.450'],... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of super sidecut skis on the epidemiology of skiing injuries. | Concerns about whether a new type of ski--the super sidecut or carving ski--has the potential to significantly alter the incidence and type of skiing injuries have arisen in the past two years. These skis have become extremely popular during the past ski season. A case control study of skiing injuries done in a serial ... | ['Athletic Injuries', 'Case-Control Studies', 'Cross-Sectional Studies', 'Equipment Design', 'Humans', 'Incidence', 'Risk Factors', 'Skiing', 'Vermont'] | 9,491,486 | [['C26.115'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents. | The therapeutic potential of stigmasterol, a natural steroid alcohol with established immune-modulatory properties, was assessed on allergic cutaneous responses. We examined its suppressive effect on immunoglobulin E (IgE)-mediated active cutaneous anaphylaxis (ACA), compound 48/80 (C48/80)-induced pruritus, and irrita... | ['Animals', 'Drug Eruptions', 'Ghana', 'Hypersensitivity', 'Mast Cells', 'Mice', 'Mice, Inbred ICR', 'Rats', 'Rats, Wistar', 'Rodentia', 'Skin', 'Stigmasterol'] | 30,140,696 | [['B01.050'], ['C17.800.174.600', 'C20.543.206.380', 'C25.100.468.380'], ['Z01.058.290.190.320'], ['C20.543'], ['A11.329.427', 'A15.382.652'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['B01.050.150.900.649.313.992.635.505.700'], ['B... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Complex protein patterns formation via salt-induced self-assembly and droplet evaporation. | Complex and elegant protein patterns in rosette, scallop, Chinese arrow and dendrite shapes at macroscopic length scales were prepared using salt-induced molecular self-assembly and droplet evaporation methods. The direct visual observation method using fluorescence microscopy was adopted to characterize the formation ... | ['Animals', 'Cattle', 'Dendrimers', 'Dose-Response Relationship, Drug', 'Kinetics', 'Microscopy, Fluorescence', 'Protein Multimerization', 'Protein Structure, Quaternary', 'Proteins', 'Salts', 'Serum Albumin, Bovine', 'Volatilization'] | 20,853,173 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['G07.690.773.875', 'G07.690.936.500'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.458', 'E05.595.458'], ['G02.111.694'], ['G02.111.570.820.709.550'], ['D12.776'], ['D01.786'], ['D12.776.034.841.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Acid and alkaline phosphatases activities in vascular smooth muscle: species differences and subcellular distribution. | 1. Acid and alkaline phosphatase activities were studied in rat and dog aortic muscle using p-nitrophenyl phosphate (p-NPP) as the substrate. Alkaline phosphatase activity was quite comparable to acid phosphatase activity in rat aortic microsomes as well as further purified plasma membranes, but considerably lower than... | ['Acid Phosphatase', 'Alkaline Phosphatase', 'Animals', 'Aorta', 'Cell Membrane', 'Centrifugation, Density Gradient', 'Dogs', 'Female', 'Hydrogen-Ion Concentration', 'Male', 'Microsomes', 'Muscle, Smooth, Vascular', 'Rats', 'Rats, Inbred Strains', 'Species Specificity'] | 3,621,905 | [['D08.811.277.352.650.025'], ['D08.811.277.352.650.035'], ['B01.050'], ['A07.015.114.056'], ['A11.284.149'], ['E05.181.724.336', 'E05.196.941.336'], ['B01.050.150.900.649.313.750.250.216.200'], ['G02.300'], ['A11.284.835.540'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['B01.050.150.900.649.313.992.63... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New guideline represents 'processed-oriented' approach for ISO 9000. | Hospitals that have been tracking the development of ISO 9000 in the health care industry should pay close attention to a new guideline about to emerge. According to Laura Preole, health care services manager of SGS International Certification Services based in Rutherford, NJ, the new guideline is the latest step in an... | ['Accreditation', 'Equipment and Supplies, Hospital', 'Guidelines as Topic', 'Health Care Sector', 'Hospital Administration', 'Humans', 'International Agencies', 'Joint Commission on Accreditation of Healthcare Organizations', 'Process Assessment, Health Care', 'Quality Control', 'United States'] | 11,216,288 | [['N03.706.110.070', 'N05.700.200.100'], ['E07.325'], ['N04.761.700.350', 'N05.700.350'], ['J01.576.489', 'N03.219.650'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.514'], ['N03.706.110.070.410', 'N05.700.200.100.420'], ['N04.761.559.650', 'N05.715.360.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
[Ulcerated plaque in the terminal aorta as a source of recurrent embolism in the young patient]. | In the last years, some case reports about peripheral arterial embolism originated from ulcerative disorders in the wall of aorta and main vascular structures, have been published. Patients affected by this disease are usually aged and arteriosclerotic injuries at divers levels are common. The current case report prese... | ['Adult', 'Aorta, Abdominal', 'Aortic Diseases', 'Embolism', 'Humans', 'Intermittent Claudication', 'Male', 'Recurrence', 'Ulcer'] | 2,339,820 | [['M01.060.116'], ['A07.015.114.056.205'], ['C14.907.109'], ['C14.907.355.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.291.937'], ['C23.550.891']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis. | Clathrin-dependent endocytosis of Na(+),K(+)-ATPase in response to dopamine regulates its catalytic activity in intact cells. Because fission of clathrin-coated pits requires dynamin, we examined the mechanisms by which dopamine receptor signals promote dynamin-2 recruitment and assembly at the site of Na(+),K(+)-ATPas... | ['Animals', 'Blotting, Western', 'Cell Line', 'Cell Membrane', 'Cells, Cultured', 'Clathrin', 'Dopamine', 'Dynamin II', 'Dynamins', 'Electrophoresis, Polyacrylamide Gel', 'Endocytosis', 'Green Fluorescent Proteins', 'Kinetics', 'Luminescent Proteins', 'Microscopy, Confocal', 'Models, Biological', 'Phosphatidylinositol ... | 12,205,083 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['A11.284.149'], ['A11.251'], ['D12.776.543.990.200'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D08.811.277.040.330.200.200', 'D12.776.220.600.4... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between the cytogenetic profile of tumor cells and response to preoperative radiochemotherapy in locally advanced rectal cancer. | Neoadjuvant radiochemotherapy to locally advanced rectal carcinoma patients has proven efficient in a high percentage of cases. Despite this, some patients show nonresponse or even disease progression. Recent studies suggest that different genetic alterations may be associated with sensitivity versus resistance of rect... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antimetabolites, Antineoplastic', 'Capecitabine', 'Chemoradiotherapy, Adjuvant', 'Chromosome Aberrations', 'Clonal Evolution', 'Cohort Studies', 'Deoxycytidine', 'Dose Fractionation, Radiation', 'Female', 'Fluorouracil', 'Humans', 'In Situ Hybridization, Fluorescence', 'Male', 'M... | 25,474,426 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D03.383.742.680.245.500.425', 'D03.383.742.698.875.404.425', 'D13.570.230.329.313', 'D13.570.685.245.500.425'], ['E02.186.079.500', 'E02.319.164.500', 'E02.815.160.500'], ['C23.550.21... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Attenuated psychosis syndrome: need for debate on a new disorder. | This 'pro' statement of the controversial issue, defending the need for a new disorder classification of attenuated psychosis syndrome (APS), provides data supporting the clinical validity of this category and responds to the most frequently asserted criticisms. It provides arguments why APS is not pathologizing non-il... | ['Antipsychotic Agents', 'Diagnostic and Statistical Manual of Mental Disorders', 'Drug Prescriptions', 'Humans', 'Psychotic Disorders', 'Severity of Illness Index', 'Syndrome', 'Unnecessary Procedures'] | 25,060,627 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['L01.453.245.945.200'], ['E02.319.307', 'N02.421.668.778.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.700.675'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.4... | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Rates, trends, and severity of depression after burn injuries. | It is commonly assumed that patients hospitalized for burn treatment will experience some level of depression. However, little is known about the trends in severity of depression over time. The purpose of this study was to determine the rates and severity of depression over a 2-year period. The Beck Depression Inventor... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Burns', 'Depressive Disorder', 'Female', 'Follow-Up Studies', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Patient Discharge', 'Predictive Value of Tests', 'Psychological Tests', 'Severity of Illness Index', 'Sex Factors', 'Time Factor... | 11,761,394 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C26.200'], ['F03.600.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Life cycle and vectorial competence of Triatoma williami (Galv?o, Souza e Lima, 1965) under the influence of different blood meal sources. | Triatoma williami is naturally infected by Trypanosoma cruzi, the ethiological agent of Chagas disease, the most significant cause of morbidity and mortality in South and Central America.The possibility of domiciliation of T. williami increases the risk of human T. cruzi vetorial transmission. Despite this, there is a ... | ['Animals', 'Brazil', 'Central America', 'Chagas Disease', 'Coturnix', 'Defecation', 'Diet', 'Humans', 'Insect Vectors', 'Life Cycle Stages', 'Mice', 'Nymph', 'Triatoma', 'Trypanosoma cruzi'] | 26,056,740 | [['B01.050'], ['Z01.107.757.176'], ['Z01.107.169'], ['C01.610.752.300.900.200', 'C01.920.625'], ['B01.050.150.900.248.350.650.350'], ['G10.261.165'], ['G07.203.650.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['B05.500', 'G07.345.500.550.500'], ['B0... | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Payment regulations for advanced practice nurses: implications for primary care. | The shortage of primary care providers (PCPs) in the United States may be worsened with health reform if more individuals receive health insurance coverage. Previous research suggests that Advanced Practice Registered Nurses (APRNs) can provide as high quality care and achieve the same health outcomes as physicians. Ho... | ['Advanced Practice Nursing', 'Delivery of Health Care', 'Health Care Reform', 'Health Services Accessibility', 'Humans', 'Insurance, Health, Reimbursement', 'Medicaid', 'Medicare', 'Nurse Practitioners', "Nurse's Role", 'Nursing Care', 'Primary Health Care', 'Reimbursement Mechanisms', 'United States'] | 20,834,022 | [['H02.478.676.074'], ['N04.590.374', 'N05.300'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.480', 'N03.219.521.710'], [... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Oral health in German children, adolescents, adults and senior citizens in 2005. | OBJECTIVE: The aim of this field study (the "Fourth German Oral Health Study") was to obtain representative data on caries (DMFT index), periodontitis (CPI) and prosthetic status in the German population and to evaluate changes in the oral health of the German people as compared with the findings of the Third German Or... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Child', 'Cohort Studies', 'Cross-Sectional Studies', 'DMF Index', 'Dental Caries', 'Dentures', 'Female', 'Germany', 'Humans', 'Jaw, Edentulous', 'Longitudinal Studies', 'Male', 'Oral Health', 'Periodontitis', 'Population Surveillance', 'Reference Standards', 'Tooth Loss'] | 19,385,435 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438.300.350', 'E06.208.266', 'N... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Identifying factors contributing to reduced breast tumor size: a longitudinal study. | AIM: This study examines the trends and outcomes of breast cancer patients who have undergone surgical procedures at the Department of Surgical Sciences, University of Insubria, Varese, Italy. It also identifies the factors that contributed to the reduction of the breast tumor size over a 13-year period at a tertiary r... | ['Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Female', 'Follow-Up Studies', 'Humans', 'Lymph Nodes', 'Mastectomy', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'Retrospective Studies', 'Risk Assessment', 'Risk Factors', 'Sentinel Lymph Node Biopsy'] | 19,131,284 | [['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], [... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Opinions and feelings on eating with complete dentures: a qualitative inquiry. | Our knowledge of variables affecting the coping strategies that lead to acceptance of foods in populations wearing complete dentures is limited. Focus groups were conducted with the specific aim of determining factors responsible for successful adaptation to chewing with complete dentures. Each of the five focus groups... | ['Adaptation, Psychological', 'Denture Retention', 'Dentures', 'Eating', 'Female', 'Food', 'Humans', 'Male', 'Mastication', 'Mouth, Edentulous', 'Surveys and Questionnaires'] | 10,765,890 | [['F01.058'], ['E06.780.346.760.550'], ['E06.780.346.760', 'E07.695.190.200'], ['G07.203.650.283', 'G10.261.330'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.283.500', 'G10.261.330.500'], ['C07.465.550', 'C07.793.597'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Treatment of tuberculosis in a nurse-managed clinic. | From July 1982 to January 1986, we saw 86 patients in the tuberculosis clinic; 77 (90%) were alcoholics; all were males, 71 (83%) were black, 14 (16%) were white, and one (1%) was hispanic. Of these, 10 patients (12%) failed to complete therapy and were referred to the Chicago Board of Health. Nine patients (10%) were ... | ['Administrative Personnel', 'Chicago', 'Hospitals, Veterans', 'Humans', 'Nurse Administrators', 'Outpatient Clinics, Hospital', 'Tuberculosis'] | 3,641,825 | [['M01.526.070'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['N02.278.421.510.180.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.070.670', 'M01.526.485.650.580', 'N02.360.650.580'], ['N02.278.035.380', 'N02.278.216.500.968.527', 'N04.452.442.452.422.527'], ['C01.1... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Home-Based and Technology-Centered Childhood Obesity Prevention for Chinese Mothers With Preschool-Aged Children. | INTRODUCTION: Nearly a quarter of preschool-aged Chinese American children are overweight or obese. Children of overweight mothers are at higher risk for obesity. Efforts to prevent obesity among low-income minority children with overweight mothers should start in early childhood.METHODOLOGY: This randomized pilot stud... | ['Adult', 'Asian Americans', 'Body Mass Index', 'California', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Mobile Applications', 'Mother-Child Relations', 'Mothers', 'Obesity', 'Surveys and Questionnaires'] | 28,826,348 | [['M01.060.116'], ['M01.686.508.200.100', 'M01.686.754.225'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.900.685'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Polyamines reduce paraquat-induced soxS and its regulon expression in Escherichia coli. | Polyamines, ubiquitous polycationic compounds, are involved in many cellular responses and relieve paraquat-induced cytotoxicity in Escherichia coli. We constructed a new E. coli mutant strain, JIL528, which is deficient in the biosynthesis of both putrescine and spermidine, to examine the physiological role of polyami... | ['Biogenic Polyamines', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Escherichia coli', 'Escherichia coli Proteins', 'Glucosephosphate Dehydrogenase', 'Mutation', 'Paraquat', 'Putrescine', 'Regulon', 'Spermidine', 'Superoxide Dismutase', 'Trans-Activators'] | 12,661,985 | [['D02.092.211.415'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D08.811.682.047.150.300'], ['G05.365.590'], ['D03.383.725.762.621'], ['D02.092.211.415.701', 'D02.092.782.258.784'], ['G05.360.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predictors of reintervention after endovascular repair of isolated iliac artery aneurysm. | The objective of this study was to identify factors predicting the need for reintervention after endovascular repair of isolated iliac artery aneurysm (IIAA). We reviewed prospectively collected database records of all patients who underwent endovascular repair of IIAA between 1999 and 2008. Detailed assessment of the ... | ['Aged', 'Aged, 80 and over', 'Angiography', 'Endovascular Procedures', 'Humans', 'Iliac Aneurysm', 'Life Tables', 'Logistic Models', 'Male', 'Middle Aged', 'Patient Selection', 'Predictive Value of Tests', 'Recurrence', 'Retreatment', 'Retrospective Studies', 'Risk Factors', 'Survival Rate', 'Tomography, X-Ray Compute... | 20,464,554 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.700.060', 'E01.370.370.050'], ['E04.100.814.529', 'E04.502.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.055.625'], ['E05.318.308.985.475', 'E05.318.740.100.500', 'N01.224.935.530', 'N06.850.505.400.975.475', 'N06.850.520.308.985.475'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptome Profile Analysis Reveals that CsTCP14 | Foliage diseases are prevalent in cucumber production and cause serious yield reduction across the world. Identifying resistance or susceptible genes under foliage-disease stress is essential for breeding resistant varieties, of which leaf-specific expressed susceptible genes are extremely important but rarely studied ... | ['Cucumis sativus', 'Disease Resistance', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Oomycetes', 'Plant Diseases', 'Plant Leaves', 'Plant Proteins', 'Potyvirus', 'Transcription Factors', 'Transcriptome'] | 31,130,701 | [['B01.650.940.800.575.912.250.300.188.666'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['E05.393.332'], ['G05.308.375'], ['B01.750.580'], ['G15.610'], ['A18.024.812'], ['D12.776.765'], ['B04.715.464.600', 'B04.715.635.600', 'B04.820.578.782.600'], ['D12.776.930'], ['G02.111.873.750', 'G... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and safety of peginterferon alpha-2a/ribavirin in treatment-naive Cameroonian patients with chronic hepatitis C. | Data were examined from a day-to-day clinical practice in Yaounde, Cameroon to evaluate the efficacy and safety of peginterferon alfa-2a and ribavirin in treatment-naive Cameroonian patients with chronic hepatitis C. Ninety adults with chronic hepatitis C (mean age, 53 +/- 8 years; 79% males; 37.8% genotype 1; 23.3% ge... | ['Adult', 'Antiviral Agents', 'Cameroon', 'Drug Therapy, Combination', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Male', 'Middle Aged', 'Polyethylene Glycols', 'Recombinant Proteins', 'Ribavirin', 'Treatment Outcome', 'Viral Load'] | 19,040,282 | [['M01.060.116'], ['D27.505.954.122.388'], ['Z01.058.290.100.110'], ['E02.319.310'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.64... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Estimation of the rate of appearance in the non-steady state with a two-compartment model. | A simple tracer-based method for calculating the rate of appearance of endogenous substances in the non-steady state, free from the inconsistencies of Steele's equation, is still lacking. This paper presents a method based on a two-compartment model by which the rate of appearance can be calculated with only a modest i... | ['Algorithms', 'Animals', 'Computer Simulation', 'Glucose', 'Glucose Clamp Technique', 'Homeostasis', 'Humans', 'Hyperinsulinism', 'Metabolism', 'Models, Biological'] | 1,514,623 | [['G17.035', 'L01.224.050'], ['B01.050'], ['L01.224.160'], ['D09.947.875.359.448'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968'], ['G03'], ['E05.599.395']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Moderate hemoptysis of unknown etiology. | The underlying cause and treatment of hemoptysis should be addressed promptly to avoid potentially life-threatening complications. We report on a previously healthy 11-year-old white boy who presented with acute hemoptysis. On bronchoscopy, bleeding was noted from the right upper and lower lobes. Right bronchial arteri... | ['Acute Disease', 'Angiography', 'Bronchial Arteries', 'Bronchoscopy', 'Catheterization, Peripheral', 'Child', 'Embolization, Therapeutic', 'Follow-Up Studies', 'Gelatin Sponge, Absorbable', 'Hemoptysis', 'Hemostatics', 'Humans', 'Male', 'Tomography, X-Ray Computed'] | 10,344,716 | [['C23.550.291.125'], ['E01.370.350.700.060', 'E01.370.370.050'], ['A07.015.114.158'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['M01.060.406'], ['E02.520.360', 'E02.926.500'], ['E05.318.372.500.750.249', ... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-â(1-40) Oligomers on Hippocampal Neurons. | Synaptic dysfunction during early stages of Alzheimer's disease (AD) is triggered by soluble amyloid-â (Aâ) oligomers that interact with NMDA receptors (NMDARs). We previously showed that Aâ induces synaptic protein loss through NMDARs, albeit through undefined mechanisms. Accordingly, we here examined the contribution... | ['Amyloid beta-Peptides', 'Animals', 'Animals, Newborn', 'Cells, Cultured', 'Dendrites', 'Gene Expression Regulation', 'Hippocampus', 'Male', 'Neurons', 'Peptide Fragments', 'Phosphorylation', 'Rats', 'Rats, Wistar', 'Receptors, N-Methyl-D-Aspartate'] | 26,836,185 | [['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['B01.050.050.282'], ['A11.251'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G05.308'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A08.675', 'A11.671'], ['D12.644.541'], ['G02.111.665', 'G02.607.780', 'G03.796'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biotin-dependent carboxylase activities in different CNS and skin-derived cells, and their sensitivity to biotin-depletion. | The validity of various transformed and untransformed CNS and skin-derived cell cultures as a model for studying effects of biotin deficiency was tested. In biotin-sufficient conditions (0.1-10 mumol/L) all cell types showed considerable activities of the four biotin-dependent carboxylases. Notably, pyruvate carboxylas... | ['Animals', 'Biotin', 'Brain', 'Carboxy-Lyases', 'Cell Line', 'Cells, Cultured', 'Culture Media', 'Fibroblasts', 'Humans', 'Keratinocytes', 'Kinetics', 'Mice', 'Mitochondria', 'Neurons', 'Oligodendroglia', 'Rats', 'Skin'] | 12,214,565 | [['B01.050'], ['D03.383.129.308.080', 'D08.211.096'], ['A08.186.211'], ['D08.811.520.224.125'], ['A11.251.210'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.409.500', 'A11.436.397'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.63... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatitis C virus genotyping versus serotyping in Egyptian patients. | BACKGROUND: The RNA genome of hepatitis C virus (HCV) displays extensive sequence variation. In this study, serotyping and genotyping techniques were applied to assess this variability by comparing the performance of the serotyping assay with a panel of well-characterized HCV strains isolated from chronic active hepati... | ['Egypt', 'Genotype', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Serotyping', 'Viremia'] | 11,261,753 | [['Z01.058.266.317'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360... | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The mortality component of health status indexes. | The mortality component of contemporary health indexes is discussed. Since these indexes reduce to mortality indexes when only life and death states enter the analysis, they share the conceptual weaknesses of mortality indexes. Also, they do not incorporate consumption variables explicity and therefore provide no struc... | ['Choice Behavior', 'Decision Making', 'Health Services', 'Health Status Indicators', 'Health Surveys', 'Humans', 'Models, Theoretical', 'Mortality'] | 1,030,695 | [['F02.463.785.373.346'], ['F02.463.785.373'], ['N02.421'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['E05.318.308.985.550', 'N01... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical outcome in gastrointestinal stromal tumor patients who interrupted imatinib after achieving stable disease or better response. | BACKGROUND: Imatinib has been found to be effective in the treatment of patients with gastrointestinal stromal tumors (GIST). We sought to evaluate the clinical outcome of imatinib interruption in GIST patients who had achieved stable disease (SD) or showed better response to imatinib therapy.METHODS: From July 2001 to... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Benzamides', 'Disease-Free Survival', 'Drug Administration Schedule', 'Female', 'Gastrointestinal Neoplasms', 'Gastrointestinal Stromal Tumors', 'Humans', 'Imatinib Mesylate', 'Male', 'Middle Aged', 'Piperazines', 'Prospective Studies', 'Pyrimidines', 'Treatment Outcome'] | 17,068,083 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E02.319.283'], ['C04.588.274.47... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lower Face Reconstruction Using the Visor Flap. | We present an alternative method instead of classical methods for lower face reconstruction in this study involving clinical experiences. We aimed to achieve more esthetic and functional results using visor flap. This flap has been used for the reconstruction of lower lip and submental region in two patients. Satisfact... | ['Aged', 'Aged, 80 and over', 'Humans', 'Lip', 'Male', 'Neck', 'Reconstructive Surgical Procedures', 'Surgical Flaps'] | 31,567,768 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.631.515', 'A14.549.336'], ['A01.598'], ['E04.680'], ['A10.850.710', 'E07.862.710']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. | The Ipl1 protein kinase is essential for proper chromosome segregation and cell viability in the budding yeast Saccharomyces cerevisiae. We have previously shown that the temperature-sensitive growth phenotype of conditional ipl1-1ts mutants can be suppressed by a partial loss-of-function mutation in the GLC7 gene, whi... | ['Amino Acid Sequence', 'Animals', 'Aurora Kinases', 'Base Sequence', 'Chromosomes', 'Enzyme Activation', 'Enzyme Inhibitors', 'Fungal Proteins', 'Genetic Complementation Test', 'Intracellular Signaling Peptides and Proteins', 'Mitosis', 'Molecular Sequence Data', 'Phosphoprotein Phosphatases', 'Protein Kinases', 'Prot... | 7,565,759 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.811.913.696.620.682.700.103', 'D12.776.167.049'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ['D12.776.354'], ['E05.393.281.526'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of probable dementia cases in undiagnosed patients using structured and unstructured electronic health records. | BACKGROUND: Dementia is underdiagnosed in both the general population and among Veterans. This underdiagnosis decreases quality of life, reduces opportunities for interventions, and increases health-care costs. New approaches are therefore necessary to facilitate the timely detection of dementia. This study seeks to id... | ['Aged', 'Aged, 80 and over', 'Delayed Diagnosis', 'Dementia', 'Electronic Health Records', 'Female', 'Humans', 'International Classification of Diseases', 'Machine Learning', 'Male', 'Veterans'] | 31,288,818 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['C10.228.140.380', 'F03.615.400'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Pheromone binding by polymorphic mouse major urinary proteins. | Mouse major urinary proteins (MUPs) have been proposed to play a role in regulating the release and capture of pheromones. Here, we report affinity measurements of five recombinant urinary MUP isoforms (MUPs-I, II, VII, VIII, and IX) and one recombinant nasal isoform (MUP-IV) for each of three pheromonal ligands, (+/-)... | ['Amino Acid Sequence', 'Animals', 'Calorimetry', 'Female', 'Ligands', 'Male', 'Mice', 'Molecular Sequence Data', 'Molecular Structure', 'Nasal Mucosa', 'Pheromones', 'Protein Binding', 'Protein Isoforms', 'Proteins', 'Recombinant Proteins', 'Sequence Alignment', 'Substrate Specificity', 'Vomeronasal Organ'] | 12,192,080 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.196.131'], ['D27.720.470.480'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['G02.111.570', 'G02.466'], ['A04.531.520', 'A04.760.600', 'A10.615.550.760.600'], ['D23.641'], ['G02.111.679', 'G03.808'], ['D12.776.800'], ['D12.776'], ['D1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Apatinib Inhibits Angiogenesis Via Suppressing Akt/GSK3â/ANG Signaling Pathway in Anaplastic Thyroid Cancer. | BACKGROUND/AIMS: Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, and there is no efficient method to slow its process. Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma patients. However, the ... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'G1 Phase Cell Cycle Checkpoints', 'Glycogen Synthase Kinase 3 beta', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Neovascularization, Physiologic', '... | 29,190,616 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.144.109.249', 'G04.144.500.320.500'], ['D05.500.117.875.500', 'D08.811.913.696.620.682.700.429.500.500', 'D08.811.913.696.620.682.700.646.625.500'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents. | 1. Intracellular recordings were made in intact and acutely dissociated vagal afferent neurones (nodose ganglion cells) of the ferret to investigate the membrane effects of histamine. 2. In current-clamp or voltage-clamp recordings, histamine (10 microM) depolarized the membrane potential (10 +/- 0.8 mV; mean +/- S.E.M... | ['Action Potentials', 'Animals', 'Diphenhydramine', 'Electric Conductivity', 'Ferrets', 'Histamine', 'Histamine Agonists', 'Histamine H1 Antagonists', 'Impromidine', 'Male', 'Methylhistamines', 'Neurons, Afferent', 'Nodose Ganglion', 'Patch-Clamp Techniques', 'Potassium', 'Potassium Channel Blockers', 'Pyrilamine', 'Re... | 9,379,409 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D02.092.471.320', 'D02.455.426.559.389.115.250'], ['G01.358.500.249.277'], ['B01.050.150.900.649.313.750.250.575.350'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['D27.505.519.625.375.400', 'D27.505.696.57... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two formats of enzyme immunoassay for the detection of saxitoxin and other paralytic shellfish poisoning toxins. | A competitive direct enzyme-linked immunofiltration assay for the detection of saxitoxin was developed, using polyclonal antibodies against saxitoxin and a saxitoxin-horseradish peroxidase conjugate. The test was performed in an eight-well plastic test device, in which antibody-coated nylon membranes were pressed tight... | ['Animals', 'Bivalvia', 'Immunoenzyme Techniques', 'Marine Toxins', 'Saxitoxin', 'Shellfish'] | 7,664,935 | [['B01.050'], ['B01.050.500.644.080'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['D23.946.580'], ['D03.633.100.759.794', 'D20.888.590.662', 'D23.946.580.590.662', 'D23.946.580.830', 'D23.946.833.590.662'], ['G07.203.300.600.875.700', 'J02.500.600.875.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
In situ coating--an approach for particle modification and encapsulation of proteins during spray-drying. | In this paper, we present a method for in situ coating of individual protein particles in a respirable size. The aim of the coating was to influence the particle/powder properties, and to reduce or prevent surface-induced conformational changes of the protein, during spray-drying, which was the method used for simultan... | ['Calorimetry, Differential Scanning', 'Chromatography, Gel', 'Circular Dichroism', 'Drug Compounding', 'Elasticity', 'Hypromellose Derivatives', 'Methylcellulose', 'Microscopy, Electron, Scanning', 'Pharmaceutical Preparations', 'Poloxamer', 'Polymers', 'Proteins', 'Serum Albumin, Bovine', 'Spectroscopy, Fourier Trans... | 16,887,302 | [['E05.196.131.310', 'E05.196.370.310'], ['E05.196.181.400.250'], ['E05.196.867.151'], ['E05.916.270'], ['G01.374.590'], ['D05.750.078.562.180.357', 'D09.698.365.180.455', 'D25.720.099.500.719', 'J01.637.051.720.099.500.719'], ['D09.698.365.180.663'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D26'], ['D02.033.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Outcome of the perioperative use of percutaneous cardiopulmonary support for adult cardiac surgery: factors affecting hospital mortality. | Percutaneous cardiopulmonary bypass support (PCPS) has become a widespread standard modality for the treatment of circulatory collapse; however, its clinical use for postcardiotomy low cardiac output syndrome (LOS) has been reported to be unsatisfactory. We reviewed the clinical outcomes of twenty-three patients underg... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Assisted Circulation', 'Cardiac Output', 'Female', 'Heart Diseases', 'Heart-Lung Machine', 'Hemodynamics', 'Hospital Mortality', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Perioperative Care', 'Risk Factors', 'Sensitivity and... | 14,961,959 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E04.050'], ['E01.370.370.380.150', 'G09.330.380.124'], ['C14.280'], ['E07.858.082.458'], ['G09.330.380'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. | PURPOSE: Understanding the molecular pathogenesis of medullary thyroid carcinoma (MTC) is prerequisite to the design of targeted therapies for patients with advanced disease.EXPERIMENTAL DESIGN: We studied by immunohistochemistry the phosphorylation status of proteins of the RAS/MEK/ERK and PI3K/AKT/mTOR pathways in 53... | ['Animals', 'Carcinoma', 'Carcinoma, Neuroendocrine', 'Cell Line, Tumor', 'Cell Movement', 'Cell Survival', 'DNA Mutational Analysis', 'Female', 'Humans', 'Lymphatic Metastasis', 'Mice', 'Mice, Inbred NOD', 'Mice, SCID', 'Mitogen-Activated Protein Kinases', 'Phosphorylation', 'Protein Processing, Post-Translational', '... | 22,753,663 | [['B01.050'], ['C04.557.470.200'], ['C04.557.465.625.650.240', 'C04.557.470.200.025.370', 'C04.557.580.625.650.240'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.346'], ['E05.393.760.700.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'],... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impacts of ozone on the biomass and yield of rice in open-top chambers. | The impacts of different O3 concentration on the biomass and yield of rice were studied by using OTC-1 open-top chambers. Experimental treatments included the activated charcoal-filtered air (CFA), 50 nl/L (CF50), 100 nl/L (CF100) and 200 nl/L (CF200) concentrations of O3. The O3 treatments significantly decreased the ... | ['Air Pollutants', 'Atmosphere Exposure Chambers', 'Biomass', 'Charcoal', 'Linear Models', 'Oryza', 'Ozone', 'Plant Stems', 'Seeds'] | 11,590,749 | [['D27.888.284.101'], ['E07.079'], ['G16.500.275.157.100', 'N06.230.124.100'], ['D01.268.150.150'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['B01.650.940.800.575.912.250.822.616'], ['D0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[The effect of anterior or posterior tibial tunnel placement of a soft tissue graft with a soft tissue interference screw on fixation biomechanics]. | OBJECTIVES: We investigated the biomechanical characteristics of anterior or posterior tibial tunnel placement of the soft tissue graft with a soft tissue interference screw in anterior cruciate ligament (ACL) reconstruction.METHODS: Twelve bovine tibiae and digital extensor tendons were divided into two homogeneously ... | ['Animals', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Injuries', 'Biomechanical Phenomena', 'Bone Screws', 'Cattle', 'Disease Models, Animal', 'Tendons', 'Tibia'] | 16,531,702 | [['B01.050'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['C26.558.554.213'], ['G01.154.090', 'G01.374.089'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['B01.050.150.900.649.313.500.380.271'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A02.880'], ['A02.835.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of food on the bioavailability of lisinopril, a nonsulfhydryl angiotensin-converting enzyme inhibitor. | A randomized, two-way, crossover study was performed on 18 normal volunteers to assess the influence of food on the bioavailability of lisinopril, (1-[N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline), a long-acting nonsulfhydryl angiotensin converting enzyme inhibitor. A single, 20-mg oral dose of lisinopril was a... | ['Adult', 'Angiotensin-Converting Enzyme Inhibitors', 'Biological Availability', 'Enalapril', 'Food', 'Humans', 'Intestinal Absorption', 'Lisinopril', 'Time Factors'] | 3,014,110 | [['M01.060.116'], ['D27.505.519.389.745.085'], ['G03.787.151', 'G07.690.725.129'], ['D12.644.456.345.360'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['D12.644.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. | The role of epigenetics in the modulation of longevity has not been studied in humans. To this aim, (1) we evaluated the DNA methylation from peripheral leukocytes of 21 female centenarians, their 21 female offspring, 21 offspring of both non-long-lived parents, and 21 young women through ELISA assay, pyrosequencing an... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'DNA', 'DNA Methylation', 'Epigenesis, Genetic', 'Female', 'Follow-Up Studies', 'Genome-Wide Association Study', 'Humans', 'Longevity', 'Middle Aged', 'Polymerase Chain Reaction', 'Retrospective Studies', 'Young Adult'] | 22,923,132 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D13.444.308'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G05.308.203'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.318.370.392', 'E05.31... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Temporal sequence of pulmonary cytokine gene expression in response to endotoxin in C3H/HeN endotoxin-sensitive and C3H/HeJ endotoxin-resistant mice. | Although previous studies suggested that tumor necrosis factor alpha (TNF-alpha) was a critical cytokine responsible for the inflammation observed after exposure to endotoxin, other mediators may also play an important role in the regulation of systemic inflammatory responses independent of TNF-alpha. The present study... | ['Animals', 'Cytokines', 'Endotoxins', 'Gene Expression', 'Granulocytes', 'Inflammation', 'Inflammation Mediators', 'Interleukin-1', 'Interleukin-10', 'Lipopolysaccharides', 'Lung', 'Mice', 'Mice, Inbred C3H', 'RNA, Messenger', 'Shock, Septic', 'Time Factors', 'Tumor Necrosis Factor-alpha'] | 7,595,058 | [['B01.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D23.946.123.329'], ['G05.297'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['C23.550.470'], ['D23.469'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid formation of myometrial gap junctions during parturition in the unilaterally implanted rat uterus. | In uterine smooth muscles, gap junction plaques rapidly form during the final stages of gestation. To investigate the related mechanisms, regional differences in myometrial gap junction development in rat uterus were examined quantitatively during delivery, using thin-section and freeze-fracture techniques in combinati... | ['Animals', 'Embryo Implantation', 'Female', 'Freeze Fracturing', 'Intercellular Junctions', 'Labor, Obstetric', 'Microscopy, Electron', 'Myometrium', 'Pregnancy', 'Pregnancy, Animal', 'Rats', 'Rats, Inbred Strains'] | 3,581,147 | [['B01.050'], ['G08.686.784.170.104.500'], ['E01.370.225.500.620.620.260', 'E01.370.225.750.600.620.260', 'E05.200.500.620.620.260', 'E05.200.750.600.620.260'], ['A11.284.149.165.420'], ['G08.686.784.769.326'], ['E01.370.350.515.402', 'E05.595.402'], ['A02.633.570.500', 'A05.360.319.679.690', 'A10.690.467.500'], ['G08.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The frame turns also: factors in differential rotation in pictures. | When pictures of simple shapes (square, diamond) were seen frontally and obliquely, (1) the shapes with a deeper extent into pictured space underwent more rotation (Goldstein, 1979), which is an apparent turning to keep an orientation toward an observer's changing position; (2) there was little effect of whether the ob... | ['Adult', 'Aged', 'Attention', 'Depth Perception', 'Discrimination Learning', 'Female', 'Field Dependence-Independence', 'Humans', 'Male', 'Middle Aged', 'Optical Illusions', 'Orientation', 'Pattern Recognition, Visual'] | 8,255,712 | [['M01.060.116'], ['M01.060.116.100'], ['F02.830.104.214'], ['F02.463.593.200', 'F02.463.593.778.255'], ['F02.463.425.280'], ['F02.463.593.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593.446.659'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.524.500', 'F02.463.593.932.622']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence and antimicrobial resistance of Salmonella serotypes in chickens from retail markets in Yaounde (Cameroon). | From February 2006 to January 2007, 150 chickens were collected from eight retail markets in Yaounde, and 90 (60%) tested positive for Salmonella. Seventy-nine chickens were contaminated with only one Salmonella serotype, 10 with two different serotypes, and 1 with four serotypes. The most prevalent serotypes were Ente... | ['Animals', 'Anti-Bacterial Agents', 'Cameroon', 'Chickens', 'Drug Resistance, Bacterial', 'Drug Resistance, Multiple, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Food Contamination', 'Meat', 'Microbial Sensitivity Tests', 'Prevalence', 'Salmonella', 'Serotyping'] | 20,438,345 | [['B01.050'], ['D27.505.954.122.085'], ['Z01.058.290.100.110'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['E05.196.401.220', 'E05.301.300.22... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Comparison of 7.2% hypertonic saline - 6% hydroxyethyl starch solution and 6% hydroxyethyl starch solution after the induction of anesthesia in patients undergoing elective neurosurgical procedures. | OBJECTIVE: The ideal solution for fluid management during neurosurgical procedures remains controversial. The aim of this study was to compare the effects of a 7.2% hypertonic saline - 6% hydroxyethyl starch (HS-HES) solution and a 6% hydroxyethyl starch (HES) solution on clinical, hemodynamic and laboratory variables ... | ['Adult', 'Anesthesia, Intravenous', 'Female', 'Fluid Therapy', 'Humans', 'Hydroxyethyl Starch Derivatives', 'Infusions, Intravenous', 'Intraoperative Period', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Plasma Substitutes', 'Saline Solution, Hypertonic', 'Treatment Outcome', 'Water-Electrolyte Balance'] | 23,644,851 | [['M01.060.116'], ['E03.155.308'], ['E02.319.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.301.915.500', 'D09.698.365.855.500'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E04.614.374', 'N02.421.585.753.374'], ['M01.060.116.630'], ['E04.525'], ['D27.505.954.502.140.500'], ['D26.776.314.890'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A rare association between mitral valve fibroelastoma and myxomatous disease with severe mitral regurgitation. | We report a rare case of association between mitral valve fibroelastoma and myxomatous disease in a patient with long history of asymptomatic myxomatous disease and progressive severe mitral regurgitation. The tumor was an intraoperative transesophageal echocardiographic finding and was confirmed during surgery. The di... | ['Diagnosis, Differential', 'Echocardiography, Transesophageal', 'Fibroma', 'Heart Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve', 'Mitral Valve Insufficiency', 'Myxoma', 'Treatment Outcome'] | 21,387,331 | [['E01.171'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['C04.557.450.565.590.340'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.510.507'], ['C14.280.484.461'], ['C04.557.450.565.550'], ['E01.789.800', 'N04.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity. | Toll-like receptor (TLR) agonists are promising adjuvants for immune therapy of cancer, but their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here, we report that among all TLR agonists tested, dendritic cells (DC) stimulated with the TLR3 agonist polyI:C displayed the strongest ... | ['Dendritic Cells', 'Flow Cytometry', 'Humans', 'Interleukin-10', 'Lipopolysaccharides', 'Signal Transduction', 'Toll-Like Receptor 3', 'Toll-Like Receptor 4'] | 21,730,023 | [['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.510', '... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vortioxetine effects on quality of life of irritable bowel syndrome patients: A randomized, double-blind, placebo-controlled trial. | WHAT IS KNOWN AND OBJECTIVE: Irritable bowel syndrome (IBS) is a functional gastrointestinal disease causing a substantial productivity loss with no definite treatment. Our study investigates the effects of vortioxetine vs placebo in enhancing the IBS patients' quality of life.METHODS: In a double-blinded, placebo-cont... | ['Adult', 'Antidepressive Agents', 'Anxiety', 'Depression', 'Double-Blind Method', 'Female', 'Humans', 'Irritable Bowel Syndrome', 'Male', 'Quality of Life', 'Surveys and Questionnaires', 'Treatment Outcome', 'Vortioxetine', 'Young Adult'] | 31,486,103 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['F01.470.132'], ['F01.145.126.350'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.158.272.608'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.30... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. | The proinflammatory cytokine TNF-alpha exerts its pleiotropic functions through activation of multiple downstream effectors, including JNK1. Yet, the underlying regulatory mechanism is incompletely understood. Here, we report that the transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppres... | ['Adaptor Proteins, Signal Transducing', 'Amino Acid Sequence', 'Animals', 'Apoptosis', 'Enzyme Activation', 'Extracellular Signal-Regulated MAP Kinases', 'Humans', 'I-kappa B Kinase', 'Kruppel-Like Transcription Factors', 'Mice', 'Mice, Knockout', 'Mitogen-Activated Protein Kinase 8', 'Nuclear Proteins', 'Proteasome E... | 19,815,509 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G04.146.954.035'], ['G02.111.263', 'G03.328'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle. | We evaluated the therapeutic potential of adenovirus (Ad)-mediated human vascular endothelial growth factor-D (hVEGF-D) gene delivery in mice. Hind limbs of hypercholesterolemic mice ( n = 120) were injected with AdhVEGF-D, AdhVEGF-A, control AdLacZ (all at 1x10(11)viral particles) or saline. Animals were killed at 4, ... | ['Adenoviridae', 'Animals', 'Blood Vessels', 'Desmin', 'Endothelium, Vascular', 'Humans', 'Lymphangiogenesis', 'Magnetic Resonance Angiography', 'Mice', 'Muscle, Skeletal', 'Neovascularization, Physiologic', 'RNA, Messenger', 'Receptors, Vascular Endothelial Growth Factor', 'Transduction, Genetic', 'Ultrasonography, Do... | 17,362,136 | [['B04.280.030'], ['B01.050'], ['A07.015'], ['D05.750.078.593.200', 'D12.776.220.475.200'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.500.325.377.437'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['A02.633.567... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Down-regulation of cell adhesion via rho-associated protein kinase (ROCK) pathway promotes tumor cell migration on laminin-511. | Epithelial cells, both normal and precancerous, stably anchor to basement membranes, whereas malignant tumors pass through them to achieve metastasis. Of basement membrane components, laminin-511 (á5, â1, ã1; LM-511) has been found to be a major isoform in many adult basement membranes. Several studies have shown that ... | ['Actins', 'Antibodies, Monoclonal', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Movement', 'Cell Shape', 'Down-Regulation', 'Flow Cytometry', 'HEK293 Cells', 'Humans', 'Integrin alpha3beta1', 'Integrin alpha6', 'Laminin', 'Signal Transduction', 'Tetradecanoylphorbol Acetate', 'Vinculin', 'rho-Associated Kinases'] | 27,068,375 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.320'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. | Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and causes several malignancies in humans. Murine herpesvirus 68 (MHV-68) is a related ã2-herpesvirus frequently used as a model to study the biology of ã-herpesviruses in vivo. The KSHV latency-associated nuclear antigen (kLANA) and t... | ['Animals', 'Antigens, Viral', 'Cell Cycle Proteins', 'Chromatin', 'Chromosomal Proteins, Non-Histone', 'Crystallography, X-Ray', 'HEK293 Cells', 'HeLa Cells', 'Herpesvirus 8, Human', 'Humans', 'Mice', 'Nuclear Proteins', 'Protein Multimerization', 'Protein Structure, Quaternary', 'Protein-Serine-Threonine Kinases', 'R... | 24,146,614 | [['B01.050'], ['D23.050.327'], ['D12.776.167'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D12.776.660.235', 'D12.776.664.235'], ['E05.196.309.742.225'], ['A11.251.210.172.750', 'A11.436.334'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B04.280.210.400.700.330... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The safety and cost-effectiveness of low osmolar contrast media. Can economic analysis determine the real worth of a new technology? | OBJECTIVES: To estimate the reduction in mortality associated with a reduced adverse reaction rate following the substitution of older high osmolar radiocontrast media (HOCM) by the newer and more expensive low osmolar contrast media (LOCM), and to assess the cost-effectiveness of switching from HOCM to LOCM in patient... | ['Australia', 'Contrast Media', 'Cost-Benefit Analysis', 'Costs and Cost Analysis', 'Drug Hypersensitivity', 'Humans', 'Life Tables', 'Meta-Analysis as Topic', 'Osmolar Concentration', 'Risk Factors'] | 1,828,529 | [['Z01.639.100', 'Z01.678.100.373'], ['D27.505.259.500', 'D27.720.259'], ['N03.219.151.125'], ['N03.219.151'], ['C20.543.206', 'C25.100.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.475', 'E05.318.740.100.500', 'N01.224.935.530', 'N06.850.505.400.975.475', 'N06.850.520.308.985.475'], ['E05.3... | ['Geographicals [Z]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Tear film interferometry and corneal surface roughness. | PURPOSE: Previous studies of optical interference from the whole thickness of the precorneal tear film showed much lower contrast than from the pre-contact lens tear film. It is hypothesized that the recorded low contrast is related to roughness of the corneal surface compared with the smooth contact lens surface. This... | ['Adult', 'Cornea', 'Female', 'Humans', 'Interferometry', 'Light', 'Male', 'Reference Values', 'Tears'] | 24,692,127 | [['M01.060.116'], ['A09.371.060.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.490'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.978.810'], ['A12.200.882']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly. | Chromatin remodelling factors and histone chaperones were previously shown to cooperatively affect nucleosome assembly and disassembly processes in vitro. Here, we show that Schizosaccharomyces pombe CHD remodellers, the Hrp1 and Hrp3 paralogs physically interact with the histone chaperone Nap1. Genome-wide analysis of... | ['Acetylation', 'Chromatin Assembly and Disassembly', 'DNA Replication', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Genome, Fungal', 'Histones', 'Nucleosomes', 'Promoter Regions, Genetic', 'Schizosaccharomyces'] | 17,510,629 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G04.400.095', 'G05.213.095', 'G05.308.095'], ['G02.111.225', 'G05.226'], ['D12.776.354'], ['G05.308.330'], ['G05.360.340.358.365'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['A11.284.430.106.279.345.190.160.180.625', 'D12.776.664.224.55... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis. | BACKGROUND: Cardiovascular morbidity and mortality have been demonstrated to be greater in psoriasis patients than in the general population. Our study aimed to assess the 10-year cardiovascular risk in patients with moderate to severe psoriasis compared with those suffering from other dermatological diseases, using th... | ['Adult', 'Cardiovascular Diseases', 'Cross-Sectional Studies', 'Female', 'Humans', 'Lipids', 'Male', 'Middle Aged', 'Obesity', 'Obesity, Morbid', 'Psoriasis', 'Risk Assessment', 'Risk Factors', 'Severity of Illness Index', 'Skin Diseases'] | 25,607,559 | [['M01.060.116'], ['C14'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C18.654.726.500.700... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A synergistic effect of oxytocin and vasopressin on sodium excretion in the neurohypophysectomized rat. | 1. Renal function and the effect of oxytocin and vasopressin replacement have been examined in anaesthetized male neurohypophysectomized rats. 2. Rates of urine flow were higher but sodium excretion markedly lower in neurohypophysectomized rats than in intact animals receiving hypotonic saline infusion (33.8 +/- 2.3 vs... | ['Animals', 'Arginine Vasopressin', 'Drug Synergism', 'Male', 'Oxytocin', 'Pituitary Gland, Posterior', 'Rats', 'Rats, Inbred Strains', 'Sodium', 'Urine'] | 3,625,542 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['G07.690.773.968.477'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['A06.300.747.875', 'A06.688.178.875', 'A06.688.357.750.875', 'A08.186.211.180.497.352.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients. | OBJECTIVE: Due to a lack of reliable biological markers, the diagnosis of irritable bowel syndrome (IBS) is based on symptom criteria. The possible physiological correlates of these criteria are not known. Our aims were to identify correlations of currently used IBS symptom criteria with distinct alterations in viscera... | ['Adult', 'Catheterization', 'Colon, Sigmoid', 'Colonic Diseases, Functional', 'Defecation', 'Female', 'Humans', 'Male', 'Pain', 'Rectum', 'Sensory Thresholds'] | 10,638,575 | [['M01.060.116'], ['E02.148', 'E05.157'], ['A03.556.124.526.356.668', 'A03.556.249.249.356.668'], ['C06.405.469.158.272'], ['G10.261.165'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['F02.463.593.710']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of sympathetic neurotransmitter release by modulators of cyclic GMP in canine vascular smooth muscle. | The contractile response to neurally released norepinephrine (NE) from sympathetic nerve endings innervating vascular smooth muscle are inhibited by substances which raise either cyclic AMP and cyclic GMP concentrations in smooth muscle. However, cyclic AMP is believed to facilitate NE release from sympathetic nerves w... | ["3',5'-Cyclic-GMP Phosphodiesterases", 'Adenylyl Cyclase Inhibitors', 'Animals', 'Cyclic GMP', 'Dogs', 'Electric Stimulation', 'Female', 'Male', 'Muscle Contraction', 'Muscle Relaxation', 'Muscle, Smooth, Vascular', 'Nerve Endings', 'Neurotransmitter Agents', 'Norepinephrine', 'Sympathetic Nervous System'] | 1,981,554 | [['D08.811.277.352.640.155', 'D12.644.360.009', 'D12.776.476.009'], ['D27.505.519.389.108'], ['B01.050'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['G11.427.494'], ['G11.427.494.554'], ['A02.633.570.49... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Duplication of the apolipoprotein C-I gene occurred about forty million years ago. | Two human apolipoprotein C-I genes, one of which is believed to be a pseudogene, are located within the lipoprotein gene cluster on chromosome 19. Alignments were made between the apoC-I and the pseudoC-I' genes using a computer sequence editor. Particular Alu sequences may be found in one gene or in both: the proposal... | ['Animals', 'Apolipoprotein C-I', 'Apolipoproteins C', 'Base Sequence', 'Biological Evolution', 'Chromosomes, Human, Pair 19', 'DNA Transposable Elements', 'Humans', 'Molecular Sequence Data', 'Multigene Family', 'Phylogeny', 'Primates', 'Pseudogenes', 'Repetitive Sequences, Nucleic Acid', 'Sequence Alignment'] | 1,646,336 | [['B01.050'], ['D10.532.091.400.500', 'D12.776.070.400.400.500', 'D12.776.521.120.400.500'], ['D10.532.091.400', 'D12.776.070.400.400', 'D12.776.521.120.400'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['A11.284.187.520.300.460.465', 'G05.360.162.520.300.460.465'], ['D13.444.308... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A systemic approach to couple therapy. | This article presents a model of couple therapy based on the reciprocal double bind. Two cases are presented to illustrate the model, and different modes of intervention are described. This paper stresses that therapy has more to do with the intersection of the maps of the world of members of a system than it has with ... | ['Behavior Therapy', 'Communication', 'Double Bind Interaction', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Marital Therapy', 'Professional-Patient Relations'] | 3,956,707 | [['F04.754.137'], ['F01.145.209', 'L01.143'], ['F01.829.131'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F04.754.864.581.136.500'], ['F01.829.401.650', 'N05.300.660']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Perceptual organization in first episode schizophrenia and ultra-high-risk states. | Deficits in perceptual organization have been consistently reported in schizophrenia, as has an association between these deficits, disorganized symptoms, and poorer premorbid functioning and prognosis, suggesting that they may be an index of illness severity or progression. It is unclear, however, whether the impairme... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Disease Progression', 'Early Diagnosis', 'Female', 'Follow-Up Studies', 'Humans', 'Least-Squares Analysis', 'Male', 'Neuropsychological Tests', 'New South Wales', 'Perceptual Disorders', 'Schizophrenia', 'Schizophrenic Psychology', 'Severity of Illness Index', 'Visual Pe... | 16,497,484 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.656'], ['E01.390'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Value of knee skin temperature measured by infrared thermography and soluble intercellular adhesion molecule-1 in the diagnosis of peri-prosthetic knee infection in Chinese individuals following total knee arthroplasty. | BACKGROUND: Total knee arthroplasty (TKA) is a successful and frequently performed procedure in orthopedic surgery. The diagnosis of peri-prosthetic joint infection following TKA remains challenging. The present study estimated the usefulness of knee skin temperature (measured by infrared thermography) and serum solubl... | ['Adult', 'Aged', 'Arthroplasty, Replacement, Knee', 'Blood Sedimentation', 'C-Reactive Protein', 'Female', 'Humans', 'Intercellular Adhesion Molecule-1', 'Interleukin-6', 'Knee Joint', 'Male', 'Middle Aged', 'Prospective Studies', 'Skin Temperature', 'Thermography'] | 25,189,954 | [['M01.060.116'], ['M01.060.116.100'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['E01.370.225.625.125', 'E05.200.625.125'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.200.450', 'D12.776.543.550.200.450',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
5-HT1A receptors: differential involvement in female and male sexual behavior in the rat. | The peripheral administration of the serotonin type 1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT) inhibited lordosis behavior in ovariectomized rats primed with estradiol benzoate. 8-OH DPAT was ineffective at 0.01 mg/kg, whereas inhibition occurred at the 0.03, 0.1, 0.3, 1, and 3 mg/k... | ['8-Hydroxy-2-(di-n-propylamino)tetralin', 'Animals', 'Brain', 'Copulation', 'Female', 'Male', 'Rats', 'Rats, Inbred Strains', 'Receptors, Serotonin', 'Serotonin', 'Sexual Behavior, Animal', 'Tetrahydronaphthalenes'] | 2,942,955 | [['D02.455.426.559.847.638.960.400', 'D04.615.638.960.400'], ['B01.050'], ['A08.186.211'], ['F01.145.113.252.748.200'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D12.776.543.750.670.800', 'D12.776.543.750.695.800', 'D12.776.543.750.720.850... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cushing's syndrome with bilateral multinodular adrenal hyperplasia. Ultrastructural, histochemical, and immunohistochemical study. | An unusual case of Cushing's syndrome of a 59-year-old man with bilateral multinodular adrenal hyperplasia and microadenoma of the pituitary gland is presented. Failure to suppress plasma cortisol with large doses of dexamethasone may suggest autonomous growth of hyperplastic nodules of the adrenals, which were at firs... | ['3-Hydroxysteroid Dehydrogenases', 'Adenoma', 'Adrenal Glands', 'Adrenocortical Hyperfunction', 'Cushing Syndrome', 'Glucosephosphate Dehydrogenase', 'Histocytochemistry', 'Humans', 'Hypothalamus', 'Immunochemistry', 'L-Lactate Dehydrogenase', 'Male', 'Middle Aged', 'Pituitary Neoplasms'] | 6,573,108 | [['D08.811.682.047.436.350'], ['C04.557.470.035'], ['A06.300.071'], ['C19.053.800'], ['C19.053.800.367'], ['D08.811.682.047.150.300'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
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