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Validating a benchmarking tool for audit of early outcomes after operations for head and neck cancer. | INTRODUCTION In 2013 all UK surgical specialties, with the exception of head and neck surgery, published outcome data adjusted for case mix for indicator operations. This paper reports a pilot study to validate a previously published risk adjustment score on patients from separate UK cancer centres. METHODS A case note... | ['Adult', 'Aged', 'Aged, 80 and over', 'Benchmarking', 'Carcinoma, Squamous Cell', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Logistic Models', 'Male', 'Medical Audit', 'Middle Aged', 'Multivariate Analysis', 'Pilot Projects', 'Postoperative Complications', 'Prospective Studies', 'ROC Curve', 'Retrospective Studie... | 27,917,662 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Chiral separation mechanisms in protein-based HPLC columns. 2. Kinetic studies of (R)- and (S)-warfarin binding to immobilized human serum albumin. | This work used plate height measurements to investigate the kinetics of (R)- and (S)-warfarin binding to an immobilized HSA column. The dissociation rate constants for (R)- and (S)-warfarin on this column increased from 0.06 to 1.9 s-1 and from 0.06 to 0.36 s-1 between 4 and 45 degrees C. The corresponding association ... | ['Chromatography, High Pressure Liquid', 'Humans', 'Kinetics', 'Serum Albumin', 'Stereoisomerism', 'Warfarin'] | 8,651,495 | [['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D12.776.034.841', 'D12.776.124.727'], ['G02.607.445.682'], ['D03.383.663.283.446.520.914', 'D03.633.100.150.446.520.914']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laser-resistant guide probe for laser treatment of endoscopically impassable tumour stenoses. | A laser-resistant guide probe that can be placed endoscopically, for use in the laser treatment of impassable tumour stenosis is described. It meets the necessary requirements such as low level of absorption of YAG laser light (1,064 nm wavelength), high thermal stability and low heat conduction. So far, the probe has ... | ['Esophageal Stenosis', 'Esophagoscopy', 'Humans', 'Laser Therapy', 'Neoplasms'] | 3,948,803 | [['C06.405.117.544'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.240.250.260', 'E04.502.250.250.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['C04']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Safety and efficacy of inhaled insulin (AERx iDMS) compared with subcutaneous insulin therapy in patients with Type 1 diabetes: 1-year data from a randomized, parallel group trial. | AIMS: Assessment of the long-term safety and efficacy of liquid inhaled insulin via AERx insulin Diabetes Management System (iDMS) in a basal/bolus treatment regimen of adults with Type 1 diabetes.METHODS: Patients were randomized 2 : 1 to prandial inhaled (n = 205) or subcutaneous (s.c.) (n = 99) insulin, plus one/two... | ['Administration, Inhalation', 'Adult', 'Diabetes Mellitus, Type 1', 'Drug Administration Schedule', 'Female', 'Humans', 'Hypoglycemic Agents', 'Injections, Subcutaneous', 'Insulin', 'Male', 'Middle Aged', 'Risk Assessment'] | 19,317,821 | [['E02.319.267.050'], ['M01.060.116'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['E02.319.267.530.620'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['M01.060.116.630'], ['E05.318.740.600.800.715', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Flow cytometrical determination of regulatory cytokines (IL-10, IL-12) and circulating dendritic cell cytokines in allergic asthmatic children. | Interleukin (IL)-10 and IL-12 have been suggested to be key regulators in the pathogenesis of allergic asthma. Several of the secretion products of dendritic cells (DC), such as IL-12, IL-10, IL-1beta and TNF-alpha, are considered to play a role in allergic asthma. This study compares the production of IL-10 and IL-12 ... | ['Adolescent', 'Adrenal Cortex Hormones', 'Asthma', 'Child', 'Child, Preschool', 'Dendritic Cells', 'Female', 'Flow Cytometry', 'Humans', 'Interleukin-1', 'Interleukin-10', 'Interleukin-12', 'Male', 'Tumor Necrosis Factor-alpha'] | 15,050,608 | [['M01.060.057'], ['D06.472.040'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['M01.060.406.448'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Exercise asthma and disodium cromoglycate. | Exercise-induced asthma (defined as a fall in PEF of at least 25% of the pre-exercise value) was studied in adult patients with uncomplicated asthma. This was found to occur in 22 out of 52 patients. Pre-exercise inhalation of disodium cromoglycate reduced the mean fall in PEF after maximal exercise from 50% of the pre... | ['Adolescent', 'Adult', 'Airway Resistance', 'Asthma', 'Chromones', 'Exercise Test', 'Female', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Physical Exertion', 'Respiration'] | 5,472,805 | [['M01.060.057'], ['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D03.383.663.283.266', 'D03.633.100.150.266'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.90... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The accuracy of combining aldosterone to renin ratio and low renin level in diagnosing primary aldosteronism]. | OBJECTIVE: To evaluate the accuracy of combing serum aldosterone to plasma rennin ratio (ARR) and low renin level in diagnosing primary aldosteronism (PA).METHODS: The ratio of serum aldosterone to plasma renin was determined in 100 patients with PA and 61 patients with primary hypertension. The optimum cut-point of AR... | ['Aged', 'Aldosterone', 'Female', 'Humans', 'Hyperaldosteronism', 'Hypertension', 'Male', 'Middle Aged', 'ROC Curve', 'Renin', 'Sensitivity and Specificity'] | 20,629,332 | [['M01.060.116.100'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.053.800.604'], ['C14.907.489'], ['M01.060.116.630'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['D08.811.277.656.074.500.78... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. | BACKGROUND: Transforming growth factor beta (TGF-beta) plays an essential role in a wide array of cellular processes. The most well studied TGF-beta response in normal epithelial cells is growth inhibition. In some cell types, TGF-beta induces an epithelial to mesenchymal transition (EMT). NMuMG is a nontransformed mou... | ['Animals', 'Cell Adhesion', 'Cell Cycle', 'Cell Line', 'Epithelial Cells', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Mammary Glands, Animal', 'Mice', 'Models, Biological', 'Oligonucleotide Array Sequence Analysis', 'Transforming Growth Factor beta'] | 14,580,254 | [['B01.050'], ['G04.022'], ['G04.144'], ['A11.251.210'], ['A11.436'], ['E05.393.332'], ['G05.308'], ['A10.336.482', 'A13.589'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D12.644.276.374.687', 'D12.644.276.954.775', 'D12.776.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PGE2 decreases reactivity of human platelets by activating EP2 and EP4. | INTRODUCTION: Platelet hyperreactivity associates with cardiovascular events in humans. Studies in mice and humans suggest that prostaglandin E2 (PGE2) regulates platelet activation. In mice, activation of the PGE2 receptor subtype 3 (EP3) promotes thrombosis, but the significance of EP3 in humans is less well understo... | ['Adult', 'Blood Platelets', 'Dinoprostone', 'Epididymal Secretory Proteins', 'Female', 'Humans', 'Male', 'Platelet Aggregation', 'beta-Defensins'] | 20,451,959 | [['M01.060.116'], ['A11.118.188', 'A15.145.229.188'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D12.776.298'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D12.644.050.200.075', 'D12.776.543.695.054.200.075']] | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structural and functional identification of two distinct inspiratory neuronal populations at the level of the phrenic nucleus in the rat cervical spinal cord. | The diaphragm is driven by phrenic motoneurons that are located in the cervical spinal cord. Although the anatomical location of the phrenic nucleus and the function of phrenic motoneurons at a single cellular level have been extensively analyzed, the spatiotemporal dynamics of phrenic motoneuron group activity have no... | ['Action Potentials', 'Animals', 'Animals, Newborn', 'Brain Stem', 'Cervical Cord', 'Cervical Vertebrae', 'Diaphragm', 'Female', 'In Vitro Techniques', 'Inhalation', 'Male', 'Motor Neurons', 'Neural Pathways', 'Neuroanatomical Tract-Tracing Techniques', 'Rats, Wistar', 'Time Factors', 'Voltage-Sensitive Dye Imaging'] | 30,251,026 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.050.282'], ['A08.186.211.132'], ['A08.186.854.126'], ['A02.835.232.834.151'], ['A02.633.567.900.300'], ['E05.481'], ['G09.772.705.700.390'], ['A08.675.655.500', 'A11.671.655.500'], ['A08.612'], ['E01.370.225.500.620.670.570', 'E01.370.225.75... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Separation of enantiomers by packed capillary electrochromatography on a cellulose-based stationary phase. | Separation of enantiomers was performed by applying packed capillary electrochromatography (CEC). Fused-silica capillaries of different lengths with an inner diameter of 100 microm were packed with a cellulose derivative immobilized onto macroporous silica gel. Parameters such as content of modifier in the mobile phase... | ['Buffers', 'Cellulose', 'Chromatography, Micellar Electrokinetic Capillary', 'Hydrogen-Ion Concentration', 'Stereoisomerism'] | 10,839,153 | [['D27.720.470.280'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['E05.196.181.500'], ['G02.300'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Quantitative assessment of surface roughness using backscattered ultrasound: the effects of finite surface curvature. | We have previously described a technique to quantify surface fibrillatory changes in osteoarthritic articular cartilage. In that study, the angular distribution of the scattered acoustic field from an insonifying source directly related to the distribution of surface fibrillatory changes. In the current study, we demon... | ['Cartilage, Articular', 'Humans', 'Models, Structural', 'Osteoarthritis', 'Surface Properties', 'Ultrasonography'] | 8,023,425 | [['A02.165.407.150', 'A02.835.583.192'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['C05.550.114.606', 'C05.799.613'], ['G02.860'], ['E01.370.350.850']] | ['Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The active form of tumor necrosis factor is a trimer. | Natural human and recombinant human and murine tumor necrosis factors (TNF) were fractionated by gel filtration chromatography on Sephadex G-75. The active form of TNF was identified by its inhibitory activity in receptor binding assays with HeLa cells and was eluted as a protein of Mr approximately 55,000. Radioiodina... | ['Animals', 'Cell Survival', 'Chemical Fractionation', 'Chromatography, Gel', 'Cross-Linking Reagents', 'Glycoproteins', 'HeLa Cells', 'Humans', 'Macromolecular Substances', 'Mice', 'Receptors, Cell Surface', 'Receptors, Tumor Necrosis Factor', 'Recombinant Proteins', 'Tumor Necrosis Factor-alpha'] | 3,034,874 | [['B01.050'], ['G04.346'], ['E05.196.155'], ['E05.196.181.400.250'], ['D27.720.470.410.210'], ['D09.400.430', 'D12.776.395'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.543.750'], ['D12.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Levels of testosterone and dihydrotestosterone in guinea pig sex canals during embryonic life]. | At the undifferentiated stage, testosterone and dihydrotestosterone levels were comparable in sexual ducts of both sexes. An hormonal sexual dimorphism appeared at the time of differentiation: while testosterone rapidly decreased in the female ducts, it considerably increased in those of the male. Testosterone rather t... | ['Animals', 'Dihydrotestosterone', 'Female', 'Guinea Pigs', 'Male', 'Mullerian Ducts', 'Sex Differentiation', 'Testosterone', 'Wolffian Ducts'] | 95,894 | [['B01.050'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['B01.050.150.900.649.313.992.550'], ['A16.623'], ['G07.345.500.325.377.843', 'G07.345.750.500', 'G08.686.841.500'], ['D04.210.500.054.079.429.824', 'D06.472.334.851.968.984'], ['A16.935']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of single nucleotide polymorphisms in three genes shows evidence for genetic isolation of certain Aspergillus flavus vegetative compatibility groups. | Genetic exchange by asexual filamentous fungi is presumed to be limited to isolates in the same vegetative compatibility group (VCG). To evaluate genetic isolation of Aspergillus flavus due to vegetative incompatibility, three gene regions were chosen that contained closely spaced nucleotides that were polymorphic amon... | ['Aspergillus flavus', 'Genes, Fungal', 'Gossypium', 'Polymorphism, Single Nucleotide', 'Seeds', 'United States'] | 17,229,064 | [['B01.300.381.081.170'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['G05.365.795.598'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['Z01.107.567.875']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Meta-Analysis of the Usefulness of Therapeutic Hypothermia After Cardiac Arrest. | Despite current guidelines recommending therapeutic hypothermia (TH) for post cardiac arrest comatose patient, its use remains limited. Randomized controlled trials (RCTs) have also reported conflicting results on the efficacy of TH. Therefore, we conducted an updated meta-analysis to evaluate the effect of TH in post ... | ['Coma', 'Heart Arrest', 'Humans', 'Hypothermia, Induced'] | 32,798,042 | [['C10.597.606.358.800.200', 'C23.888.592.604.359.800.200'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Properties of protein kinase C associated with nuclear membranes. | To study signal transduction directed towards the cell nucleus and at the nuclear membranes, we investigated the association of protein kinase C (PKC) with nuclear membranes obtained from nuclei isolated from bovine brain. By use of phorbol-ester-binding assays, significant amounts of PKC could be demonstrated in nucle... | ['Amino Acid Sequence', 'Animals', 'Bacterial Proteins', 'Blotting, Western', 'Cattle', 'Cell Nucleus', 'Cerebral Cortex', 'Chromatography, Ion Exchange', 'Detergents', 'Enzyme Activation', 'Intracellular Membranes', 'Isoenzymes', 'Molecular Sequence Data', 'Octoxynol', 'Phorbol Esters', 'Phosphorylation', 'Polyethylen... | 1,530,569 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.097'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.380.271'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A08.186.211.200.885.287.500'], ['E05.196.181.400.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Operationalizing non-lethality: a Northern Ireland perspective. | 'The troubles' over the last 33 years in Northern Ireland have claimed the lives of 3,636 people, including 302 police-officers and 644 soldiers. Of these deaths, 315 were attributed to the military and 52 to the police.(1) Formative experience of public disorder within the early parts of the conflict is reviewed. This... | ['Civil Disorders', 'Conflict, Psychological', 'Firearms', 'Humans', 'Military Science', 'Northern Ireland', 'Police', 'Social Control, Formal', 'Social Responsibility', 'Violence'] | 11,578,043 | [['I01.880.735.140'], ['F01.658.209'], ['J01.637.870.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.675'], ['Z01.542.363.602'], ['M01.526.373.750', 'M01.526.760'], ['I01.880.604', 'N03.706'], ['F01.829.500.760', 'K01.752.566.869'], ['I01.198.240.856', 'I01.880.735.900']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Health Care [N]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Chronic granulocytic leukemia in a horse. | A nine year old quarter horse exhibited progressive weight loss and inappetance over a 47 day period. There was clinical evidence of pleuritis and pneumonia substantiated by leukocytosis and elevated protein in pleural fluid. Over the entire period the horse was neutropenic and had circulating abnormal immature granulo... | ['Animals', 'Chronic Disease', 'Horse Diseases', 'Horses', 'Leukemia, Myeloid', 'Male'] | 6,941,847 | [['B01.050'], ['C23.550.291.500'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['C04.557.337.539']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of human papillomavirus infection and associated risk factors in young women in Brazil, Canada, and the United States: a multicenter cross-sectional study. | To determine the prevalence of cervical human papillomavirus (HPV) infection and risk factors in young women from Brazil, Canada, and the USA. Cross-sectional study in 3204 healthy women, aged 15 to 25 years. Cervical samples were collected for cytology and for HPV DNA detection (SPF 10-LiPA 25 system). Serum samples w... | ['Adolescent', 'Adult', 'Brazil', 'Canada', 'Cross-Sectional Studies', 'DNA, Viral', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Papillomavirus Infections', 'Prevalence', 'Risk Factors', 'United States', 'Uterine Cervical Diseases', 'Young Adult'] | 21,293,281 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['Z01.107.567.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D13.444.308.568'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An alternative animal model for comparison of treatments for cryptococcal meningitis. | Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are... | ['Animals', 'Anti-Bacterial Agents', 'Antifungal Agents', 'Colony-Forming Units Assay', 'Cryptococcosis', 'Disease Models, Animal', 'Meningitis, Cryptococcal', 'Peptides', 'Rats'] | 9,925,548 | [['B01.050'], ['D27.505.954.122.085'], ['D27.505.954.122.136'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['C01.150.703.248'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C01.150.703.181.500.500', 'C01.150.703.248.290', 'C01.207.198.500.500', 'C10.228.228.198.500.500', 'C10.228.614.300.500'], ['D1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of phase-locking is informative for studying event-related EEG activity. | A new method is presented for quantitative evaluation of single-sweep phase and amplitude electro-encephalogram (EEG) characteristics that is a more informative approach in comparison with conventional signal averaging. In the averaged potential, phase-locking and amplitude effects of the EEG response cannot be separat... | ['Adult', 'Electroencephalography', 'Evoked Potentials, Auditory', 'Humans', 'Middle Aged'] | 9,151,420 | [['M01.060.116'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Developmental changes in within- and between-network connectivity between late childhood and adulthood. | A number of behavioral changes occur between late childhood and adulthood, including maturation of social cognition, reward receptivity, impulsiveness, risk-taking and cognitive control. Although some of these abilities show linear improvements with age, some abilities may temporarily worsen, reflecting both the restru... | ['Adolescent', 'Adult', 'Age Factors', 'Analysis of Variance', 'Brain', 'Brain Mapping', 'Child', 'Child Development', 'Cognition', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Inhibition, Psychological', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neural Pathways', 'Neuropsychological Tests', ... | 23,174,403 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['F02.463.188'], ['B01.050.150.90... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene. | Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated wit... | ['Aneuploidy', 'Animals', 'Animals, Newborn', 'Blotting, Northern', 'Cell Line', 'Cell Transformation, Viral', 'Cells, Cultured', 'Chromosome Aberrations', 'Cloning, Molecular', 'Diploidy', 'Epidermal Cells', 'Gene Expression Regulation, Viral', 'Genetic Vectors', 'Humans', 'Karyotyping', 'Keratinocytes', 'Mice', 'Mice... | 1,649,895 | [['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['B01.050'], ['B01.050.050.282'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A11.251.210'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['A11.251'], ['C23.550.210', 'G05.365.590.175'], ['E05.393.220'], ['G05.700.264'], ['A1... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of the potential of a polylactic acid barrier for correction of periodontal defects in baboons: a clinical and histologic study. | Created periodontal defects in baboons were treated with one of four possible treatment modes: (1) root preparation and Epi-Guide biodegradable polylactic acid barrier, (2) root preparation and Gore-Tex e-PTFE membrane, (3) root preparation only (no barrier), and (4) no root preparation and no barrier (control). Root p... | ['Alveolar Bone Loss', 'Analysis of Variance', 'Animals', 'Evaluation Studies as Topic', 'Female', 'Furcation Defects', 'Gingival Recession', 'Guided Tissue Regeneration, Periodontal', 'Incisor', 'Lactates', 'Lactic Acid', 'Mandible', 'Maxilla', 'Membranes, Artificial', 'Molar', 'Papio', 'Periodontium', 'Polyesters', '... | 7,591,526 | [['C05.116.264.150', 'C07.465.714.354.500'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E05.337', 'N05.715.360.335'], ['C07.465.714.204'], ['C07.465.714.258.447', 'C07.465.714.354.625'], ['E04.680.300.500', 'E06.645.410', 'E06.721.485'], ['A14.549.167.860.425'], ['D02.241.511.459'... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families. | Attempts to isolate the Huntington disease (HD) gene based on its position have been frustrated by apparently contradictory recombination events in HD pedigrees that have predicted two non-overlapping candidate regions: 100 kb at the telomere of the short arm of chromosome 4, and a 2.2 Mb region located internally at 4... | ['Adult', 'Alleles', 'Asian Continental Ancestry Group', 'Chromosome Mapping', 'Family Health', 'Genetic Linkage', 'Genetic Markers', 'Genome', 'Humans', 'Huntington Disease', 'Japan', 'Linkage Disequilibrium', 'Middle Aged', 'Polymorphism, Restriction Fragment Length'] | 8,102,909 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['M01.686.508.200'], ['E05.393.183'], ['N01.400.300'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['G05.360.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.545', 'C10.228.140.380.278', 'C10.228.662.262.249.750', 'C10.574.500.497', 'C16.320.400.4... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Basic studies on the equivalent cross-relaxation rate imaging (equivalent CRI)--phantom studies. | We have studied saturation transfer in hydrophilic, cross-linked copolymer gels from irradiated polymer protons to observed water protons, using f2 (ppm) profiles of [1 - (I(infinity)/I(0))], [(I(0)/I(infinity)) - 1] or 1/T(IS)(H2O), where I(0) and I(infinity) are the longitudinal magnetization of the observed water pr... | ['Cross-Linking Reagents', 'Gels', 'Magnetic Resonance Spectroscopy', 'Magnetics', 'Phantoms, Imaging', 'Polymers', 'Protons', 'Time Factors', 'Water'] | 11,599,035 | [['D27.720.470.410.210'], ['D20.280.320', 'D26.255.165.320'], ['E05.196.867.519'], ['H01.671.493'], ['E07.671'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.249.660.500'], ['G01.910.857'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.9... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists. | Importance: A physician's prior experience caring for a patient may be associated with patient outcomes and care patterns during and after hospitalization.Objective: To examine differences in the use of health care resources and outcomes among hospitalized patients cared for by hospitalists, their own primary care phys... | ['Female', 'General Practitioners', 'Hospitalists', 'Hospitalization', 'Humans', 'Length of Stay', 'Male', 'Medicare', 'Mortality', 'Patient Discharge', 'Physicians, Primary Care', "Practice Patterns, Physicians'", 'Referral and Consultation', 'Retrospective Studies', 'United States'] | 29,131,897 | [['M01.526.485.810.485', 'N02.360.810.485'], ['M01.526.485.630.490.400', 'M01.526.485.740.422.400', 'M01.526.485.810.580', 'N02.360.630.490.400', 'N02.360.740.422.400', 'N02.360.810.580'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The impact of various work schedules on sleep complaints and minor accidents during work or leisure time: evidence from a national survey. | OBJECTIVE: To explore the prevalence of insomnia symptoms and excessive daytime sleepiness (EDS) in different work schedules and the impact of shift schedules on the risk of minor accidents during work or leisure time.METHODS: Using the data from Taiwan Social Development Trend Survey in 2005 (n = 18,794), insomnia sym... | ['Accidents', 'Accidents, Occupational', 'Adult', 'Cross-Sectional Studies', 'Female', 'Health Surveys', 'Humans', 'Leisure Activities', 'Logistic Models', 'Male', 'Multivariate Analysis', 'Prevalence', 'Risk Factors', 'Self Report', 'Sleep Disorders, Circadian Rhythm', 'Sleep Initiation and Maintenance Disorders', 'Ta... | 23,439,272 | [['N06.850.135'], ['N06.850.135.240'], ['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450'], ['E05.318.740.500.525', 'E05.318.740.600.800... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Neural basis of disjunctive eye movements. | New evidence has challenged a widely accepted interpretation of Hering's law of equal innervation, which states that disjunctive saccades are produced by the linear addition of conjugate and vergence innervation commands produced by independent oculomotor subsystems. We hypothesize, instead, that saccades are produced ... | ['Animals', 'Eye Movements', 'Haplorhini', 'Models, Neurological', 'Saccades', 'Vision, Binocular'] | 11,960,811 | [['B01.050'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400'], ['E05.599.395.642'], ['G14.350.500'], ['F02.463.593.932.885']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improvement in Protracted Wound Healing by Topical Cream Containing Lipopolysaccharide Derived from Pantoea agglomerans | BACKGROUND/AIM: The wound-healing effect of lipopolysaccharide (LPS) reportedly results from its ability to induce the removal of foreign bodies, anti-inflammatory function, and tissue-repair function. We reported the improvement of patients with protracted wound healing after the dermal administration of topical cream... | ['Administration, Topical', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Lipopolysaccharides', 'Male', 'Pantoea', 'Wound Healing'] | 29,970,576 | [['E02.319.267.120'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['B03.440.450.425.580', 'B03.660.250.150.540'], ['G16.762.891']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
PhoPR Contributes to Staphylococcus aureus Growth during Phosphate Starvation and Pathogenesis in an Environment-Specific Manner. | Microbial pathogens must obtain all essential nutrients, including phosphate, from the host. To optimize phosphate acquisition in diverse and dynamic environments, such as mammalian tissues, many bacteria use the PhoPR two-component system. Despite the necessity of this system for virulence in several species, PhoPR ha... | ['Animals', 'Bacterial Proteins', 'Female', 'Gene Expression Regulation, Bacterial', 'Humans', 'Mice, Inbred C57BL', 'Phosphates', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Virulence'] | 30,061,377 | [['B01.050'], ['D12.776.097'], ['G05.308.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['C01.150.252.410.868'], ['B03.300.390.400.800.750.100', 'B03.35... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. | We report the analysis of a Japanese male using high-throughput sequencing to ? 40 coverage. More than 99% of the sequence reads were mapped to the reference human genome. Using a Bayesian decision method, we identified 3,132,608 single nucleotide variations (SNVs). Comparison with six previously reported genomes revea... | ['Asian Continental Ancestry Group', 'Base Sequence', 'Chromosome Mapping', 'Genetic Diseases, Inborn', 'Genetic Variation', 'Genome, Human', 'Genome-Wide Association Study', 'Humans', 'Male', 'Polymorphism, Single Nucleotide', 'Translocation, Genetic'] | 20,972,442 | [['M01.686.508.200'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['C16.320'], ['G05.365'], ['G05.360.340.350'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Distribution and content of transforming growth factor-â1 and vascular endothelial growth factor in each layer of concentrated growth factors]. | OBJECTIVE: To investigate the distribution and content of transforming growth factor-â1 (TGF-â1) and vascular endothelial growth factor (VEGF) in concentrated growth factors (CGF) gel, and to clarify the difference among different layers of CGF.METHODS: Venous blood samples were collected from 6 healthy volunteers to p... | ['Blood Chemical Analysis', 'Blood Platelets', 'Blood Proteins', 'Enzyme-Linked Immunosorbent Assay', 'Giant Cells', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Leukocytes', 'Serum', 'Transforming Growth Factor beta1', 'Vascular Endothelial Growth Factor A'] | 27,752,171 | [['E01.370.225.124.100', 'E05.200.124.100'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.124'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276', 'D12.776.467', 'D23.529'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metal ions may suppress or enhance cellular differentiation in Candida albicans and Candida tropicalis biofilms. | Candida albicans and Candida tropicalis are polymorphic fungi that develop antimicrobial-resistant biofilm communities that are characterized by multiple cell morphotypes. This study investigated cell type interconversion and drug and metal resistance as well as community organization in biofilms of these microorganism... | ['Antifungal Agents', 'Biofilms', 'Candida albicans', 'Candida tropicalis', 'Colony Count, Microbial', 'Culture Media', 'Ions', 'Metals, Heavy', 'Microbial Sensitivity Tests', 'Microscopy, Confocal'] | 17,557,844 | [['D27.505.954.122.136'], ['A20.593', 'G06.120'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['B01.300.107.795.095.800', 'B01.300.381.147.800', 'B01.300.930.176.800'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D27.720.470.305', 'E07.206'], ['D01.248.497'], ['D01.268.556', 'D01.552.54... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Asbestos lung burden and asbestosis after occupational and environmental exposure in an asbestos cement manufacturing area: a necropsy study. | OBJECTIVE: The largest Italian asbestos cement factory had been active in Casale Monferrato until 1986: in previous studies a substantial increase in the incidence of pleural mesothelioma was found among residents without occupational exposure to asbestos. To estimate exposure to asbestos in the population, this study ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Asbestos, Crocidolite', 'Asbestos, Serpentine', 'Asbestosis', 'Construction Materials', 'Environmental Exposure', 'Female', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Occupational Exposure'] | 9,924,446 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D01.578.725.050.050.100', 'D01.837.725.700.760.070.050.090'], ['D01.524.500.050', 'D01.578.725.050.075', 'D01.578.725.500.050', 'D01.837.725.700.760.070.110', 'D01.837.725.700.760.535.400'], ['C08.381.483.581.125', 'C08.381.520.702.125', 'C24.800.127'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Practical Tools and Guidelines for Exploring and Fitting Linear and Nonlinear Dynamical Systems Models. | A dynamical system is a system of variables that show some regularity in how they evolve over time. Change concepts described in most dynamical systems models are by no means novel to social and behavioral scientists, but most applications of dynamic modeling techniques in these disciplines are grounded on a narrow sub... | ['Behavioral Research', 'Humans', 'Linear Models', 'Nonlinear Dynamics', 'Software'] | 30,950,646 | [['F04.096.144', 'H01.770.644.108'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['E05.599.850', 'H01.548.675'], ['L01.224.900']] | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Corneal hypoesthesia, aqueous tear deficiency, and neurotrophic keratopathy following micropulse transscleral cyclophotocoagulation in dogs. | OBJECTIVE: To describe ocular surface complications following micropulse transscleral cyclophotocoagulation (MP-TSCPC) in dogs.ANIMALS STUDIED: Eighteen dogs treated with MP-TSCPC at two institutions for glaucoma management.PROCEDURES: MP-TSCPC was applied to each eye (avoiding 3 and 9 o'clock positions) with 31.3% dut... | ['Animals', 'Corneal Diseases', 'Dog Diseases', 'Dogs', 'Glaucoma', 'Hypesthesia', 'Laser Coagulation', 'Postoperative Complications', 'Tears'] | 31,464,376 | [['B01.050'], ['C11.204'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C11.525.381'], ['C10.597.751.791.500', 'C23.888.592.763.770.500'], ['E02.520.745.410', 'E02.594.530', 'E04.014.520.530', 'E04.350.750.410', 'E04.540.630.410'], ['C23.550.767'], ['A12.200.882']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydrophobic distribution and spatial arrangement of amino acid residues in membrane proteins. | The analysis of known three-dimensional structures of membrane proteins provides an opportunity to understand their structure and stability. In this article we analyse the hydrophobic variation of amino acid residues at various ranges in membrane and aqueous parts of membrane proteins. The numerical indices for several... | ['Amino Acids', 'Computer Simulation', 'Models, Chemical', 'Photosynthetic Reaction Center Complex Proteins', 'Porins', 'Protein Conformation'] | 8,956,078 | [['D12.125'], ['L01.224.160'], ['E05.599.495'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750'], ['D12.776.157.530.400.500', 'D12.776.543.550.450.730', 'D12.776.543.585.400.730'], ['G02.111.570.820.709']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lifetime risk of total hip replacement surgery and temporal trends in utilization: a population-based analysis. | OBJECTIVE: To investigate lifetime risk of total hip replacement (THR) surgery in the state of Victoria, Australia and to describe temporal trends in THR incidence.METHODS: We analyzed a retrospective population-based longitudinal cohort of patients who received a primary THR in Victoria from 1998-2009. The factors pot... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Hip', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Osteoarthritis, Hip', 'Retrospective Studies', 'Risk', 'Social Class', 'Victoria'] | 24,470,344 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['C05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Contribution of reference electrode to the compound muscle action potential. | In compound muscle action potential (CMAP) recording, the contribution by the reference electrode is considered to be much smaller than that of the active electrode. We tested this assumption by making quantitative measurements of the signals recorded individually by the active and reference electrodes. In the thenar (... | ['Action Potentials', 'Electric Stimulation', 'Electrodes', 'Humans', 'Median Nerve', 'Muscle, Skeletal', 'Neural Conduction', 'Reaction Time', 'Reference Values', 'Ulnar Nerve'] | 17,455,266 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['E05.723.402'], ['E07.305.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.050.500'], ['A02.633.567', 'A10.690.552.500'], ['G07.265.753', 'G11.561.601'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['E05.978.810'], ['A08... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging. | A novel nano-conjugate containing ultrasmall water-soluble AuNCs protected by ovalbumin as the fluorescent part, folic acid as the targeting ligand and a homopolymer N-acryloxysuccinimide as the linker has been investigated. Moreover, specific staining of HeLa cells by the nano-conjugate has been demonstrated. | ['Drug Delivery Systems', 'Fluorescent Dyes', 'Folic Acid', 'Gold', 'HeLa Cells', 'Humans', 'Metal Nanoparticles', 'Microscopy, Fluorescence', 'Molecular Imaging', 'Molecular Structure', 'Neoplasms', 'Polymers', 'Spectroscopy, Fourier Transform Infrared', 'Staining and Labeling'] | 23,903,775 | [['E02.319.300'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D03.633.100.733.631.400'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600.500'], ['E01.370.350.515.458', 'E05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Phylogenetic analysis suggests only one serotype of Japanese encephalitis virus. | Phylogenetic analysis was performed for different genome regions of Japanese encephalitis virus (JEV). Similar genetic groupings were identified for all analyzed genome regions including complete genomes. More extensive analysis was performed for 92 isolates (complete envelope sequences) available in the GenBank. Resul... | ['Computational Biology', 'Databases, Factual', 'Encephalitis Virus, Japanese', 'Genes, env', 'Genome, Viral', 'Internet', 'Phylogeny', 'Serotyping'] | 10,821,972 | [['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B04.820.230.475.227', 'B04.820.578.344.350.300.227'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.172'], ['G05.360.340.358.840'], ['L01.224.230.110.500'], ['G05.697', 'G16.075.605',... | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Restaging surgery for women with borderline ovarian tumors: results of a French multicenter study. | BACKGROUND: The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk f... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Cystectomy', 'Disease-Free Survival', 'Female', 'France', 'Gynecologic Surgical Procedures', 'Humans', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Reoperation', 'Retrospective Studies', 'Risk Factors'] | 15,022,280 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.950.774.150'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['Z01.542.286'], ['E04.950.300'], ['B01... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Genetic and behavioural evidence of monogamy in a mammal, Kirk's dik-dik (Madoqua kirkii). | Little is known about the mating behaviour of monogamous mammals. Here, we present behavioural and genetic evidence of fidelity in a socially monogamous dwarf antelope, Kirk's dik-dik. DNA microsatellite analysis revealed no evidence of extra-pair paternity (EPP) in dik-diks: mothers' partners matched the paternal geno... | ['Animals', 'Animals, Wild', 'Antelopes', 'Female', 'Kenya', 'Male', 'Namibia', 'Seasons', 'Sexual Behavior, Animal', 'Social Behavior'] | 9,178,540 | [['B01.050'], ['B01.050.050.300'], ['B01.050.150.900.649.313.500.380.100'], ['Z01.058.290.120.400'], ['Z01.058.290.175.580'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['F01.145.113.252.748'], ['F01.145.813']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The oligomeric integrity of toposome is essential for its morphogenetic function. | Sea urchin embryos are uniquely suitable for the study of morphogenetic cell interactions. Efforts to identify the molecules responsible for morphogenetic cell adhesion led to the isolation of a 22S glycoprotein complex from Paracentrotus lividus sea urchin embryo, that has been called toposome. The biological activity... | ['Animals', 'Blastocyst', 'Cell Aggregation', 'DNA Restriction Enzymes', 'Electrophoresis, Polyacrylamide Gel', 'Glycoproteins', 'Hexosaminidases', 'Morphogenesis', 'Oligosaccharides', 'Reducing Agents', 'Sea Urchins'] | 10,101,049 | [['B01.050'], ['A16.254.500'], ['G04.198.251'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['E05.196.401.402', 'E05.301.300.319'], ['D09.400.430', 'D12.776.395'], ['D08.811.277.450.483'], ['G07.345.500'], ['D09.698.629'], ['D27.720.470.410.690'], ['B01.050.500.408.578']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunoreactivity of a 38-kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera. | Penicillium marneffei produced and secreted a 38-kDa antigen that appeared to be specific for this dimorphic fungus. This component could not be detected in antigenic extracts of Histoplasma capsulatum, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Candida a... | ['Antibodies, Fungal', 'Antigens, Fungal', 'Cross Reactions', 'HIV Infections', 'HIV Seropositivity', 'Humans', 'Immunoblotting', 'Mycoses', 'Penicillium', 'Seroepidemiologic Studies'] | 9,276,391 | [['D12.776.124.486.485.114.179', 'D12.776.124.790.651.114.179', 'D12.776.377.715.548.114.179'], ['D23.050.202'], ['G12.122.281'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.40... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Predictors and Outcomes of Persistent Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation. | Persistent tricuspid regurgitation (TR) after transcatheter aortic valve implantation (TAVI) has been reported to increase mortality. The aim of this study was to investigate clinical and echocardiographic determinants and outcome of persistent TR after TAVI. We reviewed 1,085 patients who underwent TAVI. Among them, 1... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Aortic Valve Stenosis', 'Cause of Death', 'Chronic Disease', 'Cohort Studies', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Humans', 'Kaplan-Meier Estimate', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Predictive Value ... | 31,280,838 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C23.55... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Infiltrating perineal and scrotal inflammation: rare cutaneous manifestation of familial Mediterranean fever or acne inversa?]. | Familial Mediterranean fever (FMF) can present cutaneous symptoms. In the reported case, infiltrating perineal and scrotal inflammation were attributed to FMF and treated by systemic medication with colchicine. The poor outcome of this conservative approach and pathognomonic axillary dermatological findings allowed the... | ['Abscess', 'Acne Vulgaris', 'Adult', 'Antibiotic Prophylaxis', 'Bacteroides Infections', 'Bacteroides fragilis', 'Cutaneous Fistula', 'Diagnosis, Differential', 'Familial Mediterranean Fever', 'Genital Diseases, Male', 'Humans', 'Male', 'Perineum', 'Scrotum', 'Skin'] | 18,210,069 | [['C01.830.025', 'C23.550.470.756.100'], ['C17.800.030.150', 'C17.800.794.111'], ['M01.060.116'], ['E02.319.162.150', 'E02.319.703.150'], ['C01.150.252.400.110.109'], ['B03.440.080.094.152.400', 'B03.440.425.410.194.152.400'], ['C17.800.135', 'C23.300.575.150'], ['E01.171'], ['C16.320.382.625'], ['C12.294'], ['B01.050.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. | The human Dubin-Johnson syndrome (DJS) is a rare autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of non-bile salt organic anions. A highly similar phenotype has been described for a mutant Wistar rat strain, the transport-deficien... | ['Amino Acid Sequence', 'Anion Transport Proteins', 'Antibodies, Monoclonal', 'Base Sequence', 'Carrier Proteins', 'DNA, Complementary', 'Female', 'Genes', 'Humans', 'Immunohistochemistry', 'Jaundice, Chronic Idiopathic', 'Liver', 'Middle Aged', 'Molecular Sequence Data', 'Mutation', 'Reference Values', 'Tissue Distrib... | 9,185,779 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.157.530.450.074', 'D12.776.543.585.450.074'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157'], ['D13.444.308.497.220', 'D13.444.600.223.500', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Using optimal combination of teaching-learning methods (open book assignment and group tutorials) as revision exercises to improve learning outcome in low achievers in biochemistry. | Graduate medical students of India are taught Biochemistry by didactic lectures and they hardly get any opportunity to clarify their doubts and reinforce the concepts which they learn in these lectures. We used a combination of teaching-learning (T-L) methods (open book assignment followed by group tutorials) to study ... | ['Biochemistry', 'Education, Medical, Graduate', 'Educational Measurement', 'Group Processes', 'Humans', 'Peer Group', 'Problem-Based Learning', 'Students, Medical', 'Teaching'] | 26,891,594 | [['H01.158.201', 'H01.181.122'], ['I02.358.337.350', 'I02.358.399.350'], ['I02.399'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.316.483'], ['F02.463.425.720', 'I02.158.660', 'I02.903.565'], ['M01.848.769.602'], ['I02.903']] | ['Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
A computer model for intracellular pH regulation in Chinese hamster ovary cells. | A single-cell model for Chinese hamster ovary (CHO) cells has been extended to study the regulation of intracellular pH. This model provides for the first time a direct mechanistic linkage between intracellular pH control and cellular metabolism. Among the known mechanisms that regulate and disturb pHi, the Na/H antipo... | ['Amino Acids', 'Ammonia', 'Animals', 'Buffers', 'CHO Cells', 'Carrier Proteins', 'Computer Simulation', 'Cricetinae', 'Culture Media', 'Glucose', 'Hydrogen-Ion Concentration', 'Intracellular Fluid', 'Lactates', 'Lactic Acid', 'Lysosomes', 'Mathematical Computing', 'Models, Biological', 'Sodium-Hydrogen Exchangers'] | 7,764,066 | [['D12.125'], ['D01.362.075', 'D01.625.050'], ['B01.050'], ['D27.720.470.280'], ['A11.251.210.200', 'A11.436.155'], ['D12.776.157'], ['L01.224.160'], ['B01.050.150.900.649.313.992.635.075.250'], ['D27.720.470.305', 'E07.206'], ['D09.947.875.359.448'], ['G02.300'], ['A11.284.430.429', 'A11.284.835.450', 'A12.207.515'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Correction of clubfoot deformity associated with Weber type I tibial hemimelia using the Ponseti method. | The clubfoot deformity associated with Weber type I tibial hemimelia, a rare congenital disorder, is rigid and difficult to correct. Surgeons have utilized a variety of treatment methods. Since the 1960s, some adopted the Syme amputation to produce a weightbearing lower limb. Others began to explore alternatives such a... | ['Bone Diseases, Developmental', 'Braces', 'Casts, Surgical', 'Clubfoot', 'Ectromelia', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Minimally Invasive Surgical Procedures', 'Orthopedic Procedures', 'Radiography', 'Recovery of Function', 'Tibia', 'Time Factors', 'Treatment Outcome', 'Walking', 'Weight-Bearing'] | 21,162,708 | [['C05.116.099'], ['E07.858.442.743.319'], ['E07.858.442.660.430.500', 'E07.858.690.725.430.500'], ['C05.330.488.655.063', 'C05.330.495.681.063', 'C05.660.585.512.380.813.063', 'C16.131.621.585.512.500.681.063'], ['C05.660.585.350', 'C16.131.621.585.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The dynamics of a fish stock exploited in two fishing zones. | This work presents a specific stock-effort dynamical model. The stocks correspond to two populations of fish moving and growing between two fishery zones. They are harvested by two different fleets. The effort represents the number of fishing boats of the two fleets that operate in the two fishing zones. The bioeconomi... | ['Animals', 'Fisheries', 'Humans', 'Income', 'Models, Statistical', 'Population Dynamics'] | 11,291,941 | [['B01.050'], ['J01.040.168.300', 'J03.540.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Structural and functional features and significance of the physical linkage between ER and mitochondria. | The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER). However, the physical linkage of the ER-mitochondria interface and its relevance for cell function remains elusive. We sh... | ['Amino Acid Sequence', 'Animals', 'Calcium', 'Cell Fractionation', 'Cells, Cultured', 'Endoplasmic Reticulum', 'Mitochondria, Liver', 'Models, Biological', 'Molecular Sequence Data', 'Rats', 'Tomography, X-Ray Computed'] | 16,982,799 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.242.251'], ['A11.251'], ['A11.284.430.214.190.875.248'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['E05.599.395'], ['L01.453.245.667'], ['B01.050.150.900.649.313.992.635.505.700'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Smoking cessation through the use of nicotine chewing gum: a double-blind trial in Thailand. | Two hundred cigarette smokers in Thailand were randomly assigned to receive a chewing gum containing nicotine or placebo. After six months, significantly more of the group receiving the active gum than those receiving the placebo had given up smoking. The results suggested that this treatment was more effective in high... | ['Adult', 'Chewing Gum', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Nicotine', 'Randomized Controlled Trials as Topic', 'Smoking', 'Thailand'] | 3,078,903 | [['M01.060.116'], ['D05.750.078.739.249', 'D09.698.700.249', 'D20.215.721.249.249', 'G07.203.300.140.200', 'J02.500.140.200'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['E05.318.372.250.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
[Primary stent implantation in the internal carotid artery]. | BACKGROUND AND OBJECTIVE: Advances in interventional catheter technology have made it possible to dilate stenoses also in the internal carotid artery (ICA). This may cause cerebral emboli, but primary stent implantation may fixate atherosclerotic material on the vessel wall and thus prevent embolization.PATIENTS AND ME... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carotid Artery, Internal', 'Carotid Stenosis', 'Catheterization', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Embolism', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Radiography', 'Recurrence', 'Stents', 'Stroke'] | 10,587,712 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114.186.200.230'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E02.148', 'E05.157'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures. | Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficacy of decoquinate against... | ['Abortion, Veterinary', 'Animals', 'Cattle', 'Cattle Diseases', 'Cells, Cultured', 'Coccidiosis', 'Coccidiostats', 'Decoquinate', 'Female', 'Humans', 'Larva', 'Male', 'Neospora', 'Pregnancy', 'Pregnancy Complications, Parasitic', 'Ruminants', 'Skin'] | 9,066,049 | [['C13.703.039.422', 'C22.021'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['A11.251'], ['C01.610.752.250'], ['D27.505.954.122.250.100.170'], ['D03.633.100.810.350.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.043.075.189.250.750.550']... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Results of the treatment of Hirschsprung disease using the Duhamel operation]. | The Duhamel operation was performed on 136 children with Hirschsprung's disease. Eight patients died. Results of the operation were studied in 121 patients within the terms of from 1 to 17 years. Late complications were noted in 7 patients. In the other 114 patients remote results of the treatment were good. | ['Adolescent', 'Child', 'Child, Preschool', 'Colon', 'Hirschsprung Disease', 'Humans', 'Infant', 'Methods', 'Rectum'] | 6,675,240 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C06.198.439', 'C06.405.469.158.701.439', 'C16.131.314.439'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.581'], ['A03.556.124.526.767', 'A03.556.249.249.767']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Assessment of exposure to chloramphenicol and azathioprine among workers in a South African pharmaceutical plant. | There have been very few published studies that have evaluated exposure to myelotoxic drugs among production workers in pharmaceutical plants. Previous studies have focussed mainly on nurses and evaluated exposure to cytotoxic drugs using urine mutagenicity as a marker of exposure. The aim of this study was to evaluate... | ['Adult', 'Air Pollutants, Occupational', 'Azathioprine', 'Blood Cell Count', 'Case-Control Studies', 'Chloramphenicol', 'Drug Industry', 'Environmental Monitoring', 'Humans', 'Male', 'Mercaptopurine', 'Occupational Exposure', 'South Africa', 'Uric Acid'] | 8,406,906 | [['M01.060.116'], ['D27.888.284.101.268'], ['D02.886.759.111', 'D03.633.100.759.570.090', 'D13.570.900.111'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
The pathogenesis of chronic inflammation and malignant transformation in the human upper airways: the role of beta-defensins, eNOS, cell proliferation and apoptosis. | The surrounding environment contains plenty of pathogens, which represent a danger of infection. The simplest way for the pathological microorganism to enter the organism is the upper airways. Inflammation of the upper airways is among the most common and frequent diseases. This category includes nasal polyposis and ch... | ['Apoptosis', 'Caspase 3', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Chronic Disease', 'Fluorescent Antibody Technique, Indirect', 'Humans', 'Inflammation', 'Ki-67 Antigen', 'Nasal Mucosa', 'Nasal Polyps', 'Nitric Oxide Synthase Type III', 'Tonsillar Neoplasms', 'Tonsillitis', 'beta-Defensins'] | 19,475,527 | [['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C23.550.291.500'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.75... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Experimental combined chemo- and endocrine therapy with UFT and tamoxifen in human breast carcinoma xenografts serially transplanted into nude mice]. | We have investigated the experimental combined chemo- and endocrine therapy of UFT and tamoxifen (TAM) on two human breast carcinoma xenografts, R-27 and Br-10 with estrogen receptors (ER) serially transplanted into nude mice. When sc inoculated tumor started the exponential growth, the treatments were initiated in fou... | ['Animals', 'Breast Neoplasms', 'Combined Modality Therapy', 'Female', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Neoplasm Transplantation', 'Neoplasms, Hormone-Dependent', 'Tamoxifen', 'Tegafur', 'Transplantation, Heterologous'] | 2,074,386 | [['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['E02.186'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['E05.624'], ['C04.626'], ['D02.455.426.559.389.150.700.900'], ['D03.383.74... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatigue failure and molecular machine design. | Sophisticated molecular machines have evolved in nature, and the first synthetic molecular machines have been demonstrated. With our increasing understanding of individual operating cycles, the question of how operation can be sustained over many cycles comes to the forefront. In the design of macroscale machines, perf... | ['Fatigue', 'Humans', 'Myosins', 'Nanotechnology'] | 21,574,250 | [['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.730.475', 'D08.811.277.040.025.193.750', 'D12.776.210.500.600', 'D12.776.220.525.475'], ['H01.603', 'J01.897.520.600']] | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. | AIM: To investigate the role of Helicobacter pylori, expressing the virulence marker CAGA (cytotoxin associated gene product A) in ulcer complications and its interaction with nonsteroidal anti-inflammatory drugs (NSAIDs) and other risk factors.DESIGN: Case control study using conditional logistic regression analysis.S... | ['Adult', 'Aged', 'Anti-Inflammatory Agents, Non-Steroidal', 'Antigens, Bacterial', 'Aspirin', 'Bacterial Proteins', 'Case-Control Studies', 'Duodenal Ulcer', 'Female', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Middle Aged', 'Odds Ratio', 'Peptic Ulcer Hemorrhage', 'Risk Factors', 'Smoking'] | 11,876,703 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D23.050.161'], ['D02.455.426.559.389.657.410.595.176'], ['D12.776.097'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.405.469.275.800.348', 'C06.405.748.586... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Mirapex (pramipexole) in the treatment of non-motor disturbances in Parkinson's disease]. | The effect of the dopamine receptor antagonist mirapex on emotional disorders (anxiety, depression), cognitive disturbances and sleep disorders has been studied in 66 patients with Parkinson's disease. Mirapex has been administered in addition to levodopa and other antiparkinsonian drugs in dosage 3,5+/-1,1 mg daily to... | ['Antiparkinson Agents', 'Anxiety', 'Benzothiazoles', 'Depression', 'Dose-Response Relationship, Drug', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Parkinson Disease', 'Pramipexole', 'Receptors, Dopamine D1', 'Sleep Wake Disorders', 'Treatment Outcome'] | 18,577,955 | [['D27.505.954.427.090.050'], ['F01.470.132'], ['D03.383.129.708.089', 'D03.633.100.185'], ['F01.145.126.350'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.2... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serial changes in ultrasound-guided fine needle aspiration cytology in subacute thyroiditis. | OBJECTIVE: To elucidate the serial cytologic presentations of subacute thyroiditis (SAT) with ultrasound-guided fine needle aspiration (FNA).STUDY DESIGN: Nine patients with clinically evident SAT were recruited; serial sonography and ultrasound-guided fine needle aspiration cytology were performed.RESULTS: Sixty-one f... | ['Adult', 'Biopsy, Needle', 'Female', 'Fibroblasts', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Thyroiditis, Subacute', 'Ultrasonography'] | 9,100,749 | [['M01.060.116'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['A11.329.228'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chromogranin As a Biochemical Marker of Neuroendocrine Tumors. | Comparative study of plasma chromogranin A levels was carried out in 227 patients with neuroendocrine tumors of various locations and 66 normal subjects, men and women, by standard ELISA. In patients with tumors of all locations (pancreas, stomach, small and large intestine, and lungs), the glycoprotein levels were sig... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Chromogranin A', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuroendocrine Tumors', 'Sensitivity and Specificity', 'Young Adult'] | 27,021,085 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['D12.776.631.199.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.465.625.650', 'C04.557.580.625.650'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proteolytic cascade in the amyloidogenesis of Alzheimer's disease. | beta-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. beta-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which are dispersed by statins. | ['Alzheimer Disease', 'Amyloid Precursor Protein Secretases', 'Amyloid beta-Peptides', 'Androstenes', 'Aspartic Acid Endopeptidases', 'Cell Line', 'Cholesterol', 'Endopeptidases', 'Gene Expression Regulation', 'Glycosylation', 'Humans', 'Hydrogen-Ion Concentration', 'Protein Processing, Post-Translational', 'Signal Tra... | 14,748,707 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D08.811.277.656.300.032'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D04.210.500.054.079'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['A11.251.210'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.57... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of schedule of reinforcement on a pentobarbital discrimination in rats. | The purpose of this study was to determine the effects of the schedule of reinforcement on a pentobarbital discrimination in rats. Five rats were trained to discriminate 10 mg/kg pentobarbital from saline under a multiple fixed-interval 180-s fixed-ratio 20 schedule of reinforcement. During both saline and pentobarbita... | ['Animals', 'Appetitive Behavior', 'Arousal', 'Attention', 'Dextroamphetamine', 'Discrimination Learning', 'Dizocilpine Maleate', 'Dose-Response Relationship, Drug', 'Male', 'Pentobarbital', 'Phencyclidine', 'Rats', 'Rats, Inbred Strains', 'Reinforcement Schedule'] | 1,955,819 | [['B01.050'], ['F01.145.113.111'], ['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['D02.092.471.683.152.110.200'], ['F02.463.425.280'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.383.742.698.253.593'], ['D03.383.621.699'], ['B01.050.150.900.649.313.99... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Supratentorial and spinal cord hemangioblastomas: gadolinium enhanced MR appearance with pathologic correlation. | A case is presented that illustrates the magnetic resonance appearance of supratentorial hemangioblastomas both prior to and following intravenous administration of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Spinal cord hemangioblastomas were also present and were visualized only after Gd-DTPA administra... | ['Adult', 'Gadolinium', 'Hemangiosarcoma', 'Humans', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Male', 'Neoplasms, Multiple Primary', 'Spinal Cord Neoplasms', 'Supratentorial Neoplasms'] | 2,584,483 | [['M01.060.116'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['C04.557.450.795.390', 'C04.557.645.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.825.500'], ['C04.651'], ['C04.588.614.250.803', 'C10.228.854.765', 'C10.551.240.750'], ['C04.588.614.25... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Beryllium-7 as a tracer of short-term sediment deposition and resuspension in the Fox River, Wisconsin. | Short-term (approximately monthly) sediment deposition and resuspension rates of surficial bed sediments in two PCB-laden impoundments on the Fox River, WI, were determined in the summer and fall of 1998 using 7Be, a naturally occurring radioisotope produced in the atmosphere. Decay-corrected activities and inventories... | ['Beryllium', 'Environmental Monitoring', 'Isotopes', 'Water Pollutants, Chemical', 'Wisconsin'] | 11,347,601 | [['D01.268.552.075', 'D01.268.557.080', 'D01.552.547.080'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.496'], ['D27.888.284.903.655'], ['Z01.107.567.875.350.900', 'Z01.107.567.875.510.900']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Stereomutation of axially chiral aryl coumarins. | Coumarins substituted by an aryl group in position 4 display restricted rotation about the Ar-C4 bond, giving rise to conformational or configurational enantiomers (atropisomers) when such a restricted motion leads to a C(1) symmetry. The dynamics of the stereomutation processes of these axial enantiomers was monitored... | ['Circular Dichroism', 'Computer Simulation', 'Coumarins', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Stereoisomerism'] | 20,698,560 | [['E05.196.867.151'], ['L01.224.160'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Frequency variations of discrete cranial traits in major human populations. III. Hyperostotic variations. | Seven discrete cranial traits usually categorised as hyperostotic characters, the medial palatine canal, hypoglossal canal bridging, precondylar tubercle, condylus tertius, jugular foramen bridging, auditory exostosis, and mylohyoid bridging were investigated in 81 major human population samples from around the world. ... | ['Cephalometry', 'Female', 'Gene Frequency', 'Genetic Variation', 'Genetics, Population', 'Humans', 'Hyperostosis', 'Male', 'Sex Distribution', 'Skull'] | 11,554,504 | [['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['G05.330'], ['G05.365'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.540'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850'], ['A02.835.232.781']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation. | Neuregulin is required for proper oligodendrocyte development, but which receptors are involved and whether neuregulin promotes or inhibits maturation remain controversial. To assess the roles of the neuregulin receptor ErbB4 in oligodendrocyte development, we examined oligodendrocyte initiation and maturation in cultu... | ['Animals', 'Base Sequence', 'Cells, Cultured', 'DNA Primers', 'Embryo, Mammalian', 'ErbB Receptors', 'Gene Expression Regulation, Developmental', 'Immunohistochemistry', 'Mice', 'Mice, Knockout', 'Nervous System', 'Oligodendroglia', 'Rats', 'Receptor, ErbB-4', 'Reverse Transcriptase Polymerase Chain Reaction', 'Spinal... | 15,958,742 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A16.254'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['G05.308.310'], ['E01.370.225.500.607.512', 'E01.370.225.750.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Investigation of pregnancy hypertension as a consequence of utero-placentar ischemia (author's transl)]. | An attempt at provoking gestosis by constricting the uterine artery was made using pregnant rats and rabbits. The experiment failed. Reducing the circulation by means of Z-sutures in the region of the nidation site failed to produce symptoms of gestosis also. The result of the uterine manipulations was abortion and int... | ['Animals', 'Disease Models, Animal', 'Female', 'Hypertension', 'Ischemia', 'Placenta', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Complications', 'Rats', 'Uterus'] | 578,103 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C14.907.489'], ['C23.550.513'], ['A16.710'], ['C13.703.395.249'], ['G08.686.784.769'], ['C13.703'], ['B01.050.150.900.649.313.992.635.505.700'], ['A05.360.319.679']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcomes of incidentally discovered thyroid nodules referred to a high-volume head and neck surgeon. | BACKGROUND: Incidental thyroid nodules are commonly found by radiological studies done for other indications. The yearly incidence of thyroid cancer is increasing, in part because of detection of nonpalpable nodules on imaging performed for unrelated issues.METHODS: All new patients referred to a high-volume thyroid su... | ['Adult', 'Aged', 'Biopsy, Fine-Needle', 'Carcinoma, Papillary', 'Cohort Studies', 'Diagnosis, Differential', 'Diagnostic Imaging', 'Female', 'Follow-Up Studies', 'Head and Neck Neoplasms', 'Humans', 'Incidental Findings', 'Male', 'Middle Aged', 'Referral and Consultation', 'Retrospective Studies', 'Risk Assessment', '... | 23,729,010 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100.119.500', 'E01.370.225.998.054.119.500', 'E01.370.388.100.100.500', 'E04.074.119.500', 'E04.665.100.500', 'E05.200.500.384.100.119.500', 'E05.200.998.054.119.500', 'E05.242.384.100.119.500'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['E05.318.372.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical research informatics: a conceptual perspective. | Clinical research informatics is the rapidly evolving sub-discipline within biomedical informatics that focuses on developing new informatics theories, tools, and solutions to accelerate the full translational continuum: basic research to clinical trials (T1), clinical trials to academic health center practice (T2), di... | ['Biomedical Research', 'Humans', 'Medical Informatics', 'Models, Theoretical', 'Translational Medical Research'] | 22,523,344 | [['H01.770.644.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500'], ['E05.599'], ['H01.770.644.145.675']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Cardiovascular and endocrine effects of clonidine premedication in neurosurgical patients. | The present study was conducted to examine the haemodynamic and endocrine effects of clonidine, given as sole preanaesthetic medication, in neurosurgical patients. Nineteen patients of ASA physical status I and II, subjected to craniotomy, randomly received po premedication of either clonidine (300 micrograms, n = 9) o... | ['Administration, Oral', 'Aldosterone', 'Blood Glucose', 'Clonidine', 'Craniotomy', 'Depression, Chemical', 'Double-Blind Method', 'Epinephrine', 'Hemodynamics', 'Humans', 'Hydrocortisone', 'Middle Aged', 'Norepinephrine', 'Preanesthetic Medication'] | 1,742,817 | [['E02.319.267.100'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['D09.947.875.359.448.500'], ['D03.383.129.308.436.500'], ['E04.525.190'], ['G07.690.773.750'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High density lipoprotein cholesterol concentration as a predictor of coronary heart disease in West Indian men. | STUDY OBJECTIVE: The aim of the study was to determine whether the inverse association between high density lipoprotein cholesterol concentration and risk of coronary heart disease described in people of European stock was also present in other racial groups.DESIGN: The study was a prospective population survey. Cardio... | ['Adult', 'Aged', 'Cholesterol, LDL', 'Continental Population Groups', 'Coronary Disease', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Regression Analysis', 'Risk Factors', 'Trinidad and Tobago'] | 2,370,501 | [['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['M01.686.508'], ['C14.280.647.250', 'C14.907.585.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Determination of blood pressure by indirect methods in dogs given acetylpromazine maleate. | This study was designed to monitor and compare indirect blood pressures by two methods (ultrasonic Doppler and photoelectric) after intravenous acetylpromazine maleate at three different doses (0.11, 0.55, and 1.10 mg/kg). Sixteen unanesthetized dogs were placed in right lateral recumbency and pressures estimated from ... | ['Acepromazine', 'Animals', 'Blood Pressure', 'Blood Pressure Determination', 'Dogs', 'Female', 'Male', 'Ultrasonics'] | 7,226,849 | [['D02.886.369.029', 'D03.633.300.783.029'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['B01.050.150.900.649.313.750.250.216.200'], ['H01.671.031.849']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Caring: searching for consensus or principle of necessary conflict?]. | By dint of habits, the demand of consensus substitute the poison for the remedy. The consensus sounds the death knell for the ethics. Pursuing (striving towards) the unity, the consensus demonizes the conflict and seek explicitly a way to eliminate it regarding its visible chaos. A contrario, dissensus assures, by the ... | ['Consensus', 'Ethics, Nursing', 'Humans', 'Philosophy, Nursing'] | 24,236,395 | [['F01.829.316.068', 'F02.463.785.373.433'], ['K01.752.566.479.171.132.875', 'K01.752.712.416', 'N05.350.340.162.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.752.712']] | ['Psychiatry and Psychology [F]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Altered expression of connexin-43 and impaired capacity of gap junctional intercellular communication in prostate cancer cells. | Connexin-43 (Cx43) expression in prostate cancer (PCa) cells and the potency of gap junctional intercellular communication (GJIC) in the cells were investigated, with an attempt to elucidate the reason why the so-called "bystander effect" mediated by thymidine kinase (TK) suicide gene therapy on PCa cells is not of sig... | ['Cell Communication', 'Cell Line, Tumor', 'Connexin 43', 'Gap Junctions', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immunohistochemistry', 'Male', 'Prostatic Neoplasms', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction'] | 17,641,845 | [['G04.085'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.543.585.250.200'], ['A11.284.149.165.420.471'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512',... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Validated method for determination of mazindol in human plasma by liquid chromatography/tandem mass spectrometry. | A simple liquid chromatography/tandem mass spectrometry (LC/MS/MS) method with electrospray ionization in positive ion multiple reaction monitoring mode was developed for the quantification of mazindol (an anorectic agent) in human plasma. Fluoxetine was adopted as an internal standard (IS), and sample preparation invo... | ['Chromatography, Liquid', 'Humans', 'Mazindol', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry'] | 19,272,843 | [['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.513.500'], ['E05.196.566.600'], ['E05.196.566.880']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dissecting the salt dependence of the Tus-Ter protein-DNA complexes by high-throughput differential scanning fluorimetry of a GFP-tagged Tus. | The analysis of the salt dependence of protein-DNA complexes provides useful information about the non-specific electrostatic and sequence-specific parameters driving complex formation and stability. The differential scanning fluorimetry of GFP-tagged protein (DSF-GTP) assay has been geared with an automatic Tm peak re... | ['Base Sequence', 'DNA Replication', 'DNA, Bacterial', 'Escherichia coli', 'Escherichia coli Proteins', 'Fluorometry', 'Green Fluorescent Proteins', 'High-Throughput Screening Assays', 'Protein Binding', 'Sodium Chloride'] | 24,113,739 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.225', 'G05.226'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['E05.196.712.516.600'], ['D12.776.532.265'], ['E05.916.680'], ['G02.111.679', 'G03.808'], ['D01.210.450.150.875', 'D01.857.650']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Primary myelofibrosis: a detailed statistical analysis of the clinicopathological variables influencing survival. | In the present study we analyzed the prognostic significance of several clinical, hematological, and histological parameters recorded at diagnosis in a consecutive series of 72 patients with primary myelofibrosis (PMF). Univariate analysis showed that the most significant indicators of poor survival were the following:... | ['Adult', 'Aged', 'Female', 'Fever', 'Hemoglobins', 'Humans', 'Male', 'Megakaryocytes', 'Middle Aged', 'Multivariate Analysis', 'Primary Myelofibrosis', 'Prognosis', 'Retrospective Studies', 'Survival Analysis'] | 8,003,563 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.119.344'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.148.479', 'A15.378.316.479'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C15.378.190.636.765'], ['E01.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. | BACKGROUND: The microRNAs (miRNAs) are an extensive class of small noncoding RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In Caenorhabditis elegans, lin-4 and let-7 miRNAs control the timing of fate specification of neuronal and hypodermal cells during larval development. lin-4,... | ['Adult', 'Animals', 'Brain', 'Caenorhabditis elegans Proteins', 'Carcinoma, Embryonal', 'Cell Differentiation', 'Cell Line', 'Cell Line, Tumor', 'Down-Regulation', 'Embryo, Mammalian', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Neoplastic', 'Genes, Neoplasm',... | 15,003,116 | [['M01.060.116'], ['B01.050'], ['A08.186.211'], ['D12.776.419.500'], ['C04.557.465.200'], ['G04.152'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A16.254'], ['E05.393.332'], ['G05.308.310'], ['G05.308.370'], ['G05.360.340.024.340.375'], ['G05.348'], ['B... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. | Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked closely with the progression of Alzheimer's disease (AD), which is a neurodegenerative disorder characterized by memory impairment, and ... | ['Acetylcholinesterase', 'Alkaloids', 'Alzheimer Disease', 'Binding Sites', 'Cholinesterase Inhibitors', 'Databases, Chemical', 'Donepezil', 'Drug Discovery', 'Galantamine', 'Humans', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'Protein Binding', 'Quantitative Structure-Activity Relationship', 'Ses... | 30,823,604 | [['D08.811.277.352.100.170.176'], ['D03.132'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['G02.111.570.120'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['L01.313.500.750.300.188.400.300', 'L01.470.750.750.300'], ['D02.455.426.559.847.486.487.280', 'D03.383.621.2... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Peanut butter and fatal fluoride poisoning. A case of mistaken identity. | We report here a case of an adult seeking a late night peanut butter snack who mistook for peanut butter a fluoride containing glass etching compound. The glass etching compound was of a color and consistency similar to peanut butter and was packaged in a similar appearing container. The decedent survived for six hours... | ['Arachis', 'Fatal Outcome', 'Fluoride Poisoning', 'Humans', 'Male', 'Middle Aged'] | 8,166,114 | [['B01.650.940.800.575.912.250.401.077'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C25.723.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. | Using human and bovine short cDNA sequences as probes we screened human cosmid and P1 libraries for components of the complex I multi-subunit enzyme of oxidative phosphorylation. We isolated genomic recombinants encoding cI-B8 (gene NDUFA2), cI-B14 (gene NDUFA6), cI-B14.5a (gene NDUFA7), cI-ASHI (gene NDUFB8) and cI-23... | ['Animals', 'Cattle', 'Chromosome Mapping', 'Cosmids', 'DNA, Complementary', 'Electron Transport', 'Genetic Linkage', 'Genome, Human', 'Humans', 'In Situ Hybridization, Fluorescence', 'Mutation', 'NAD(P)H Dehydrogenase (Quinone)', 'Polymerase Chain Reaction'] | 9,345,899 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.183'], ['G05.360.337.500', 'G05.360.600.250'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G05.348'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucosinolates from Cardaria draba. | A new glucosinolate salt, L-prolinium 4-(methylsulfinyl)butyl glucosinolate, was isolated from the flowering heads of Cardaria draba and characterized by current spectroscopic methods. | ['Brassicaceae', 'Glucosinolates', 'Humans', 'Phytotherapy', 'Plant Extracts'] | 11,978,437 | [['B01.650.940.800.575.912.250.157'], ['D02.886.740.703.350', 'D09.408.348.820.350', 'D09.408.903.703.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.755'], ['D20.215.784.500', 'D26.667']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RBP-Jê-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice. | The Notch signaling pathway is an ubiquitous cell-cell interaction mechanism, which is essential in controlling processes like cell proliferation, cell fate decision, differentiation or stem cell maintenance. Recent data have shown that Notch signaling is RBP-Jê-dependent in melanocytes, being required for survival of ... | ['Animals', 'Cell Proliferation', 'Immunoglobulin J Recombination Signal Sequence-Binding Protein', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Receptors, Notch', 'Retinal Pigment Epithelium', 'Signal Transduction'] | 20,856,205 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.260.457', 'D12.776.660.486', 'D12.776.930.327'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D12.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine. | A series of new 5-(1-hydroxy-2-iodoethyl)-2'-deoxyuridine and uridine compounds (11, 16) was synthesized by the regiospecific addition of HOI to the vinyl substituent of 5-vinyl-2'-deoxyuridine (10a), 5-vinyl-2'-fluoro-2'-deoxyuridine (10b), 5-vinyluridine (10c), and (E)-5-(2-iodovinyl)-2'-deoxyuridine (4b). Treatment ... | ['Animals', 'Antimetabolites, Antineoplastic', 'Antiviral Agents', 'Biological Transport', 'Cell Survival', 'Chemical Phenomena', 'Chemistry', 'Deoxyuridine', 'In Vitro Techniques', 'Leukemia L1210', 'Leukemia P388', 'Mice', 'Tumor Cells, Cultured', 'Uridine', 'Vinyl Compounds'] | 2,299,637 | [['B01.050'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D27.505.954.122.388'], ['G03.143'], ['G04.346'], ['G02'], ['H01.181'], ['D03.383.742.680.852.300', 'D13.570.230.430', 'D13.570.685.852.300'], ['E05.481'], ['C04.557.337.372.594', 'C04.619.531.594'], ['C04.557.337.372.782', 'C04.619.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Photochemical defluorination of aqueous perfluorooctanoic acid (PFOA) by Fe(0)/GAC micro-electrolysis and VUV-Fenton photolysis. | Perfluorooctanoic acid (PFOA) is extremely persistent and bioaccumulative in the environment; thus, it is very urgent to investigate an effective and moderate technology to treat the pollution of PFOA. In this study, a process combined iron and granular activated carbon (Fe(0)/GAC) micro-electrolysis with VUV-Fenton sy... | ['Caprylates', 'Carbon', 'Electrolysis', 'Fluorocarbons', 'Hydrogen Peroxide', 'Photolysis'] | 27,030,239 | [['D02.241.081.222', 'D10.251.122'], ['D01.268.150'], ['E05.301.250'], ['D02.455.526.510.435'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['G02.740.685']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Melamine urinary bladder stone. | We report a unique case of a melamine bladder urinary stone. A physiopathologic mechanism of formation is proposed and discussed. | ['Female', 'Humans', 'Infant', 'Triazines', 'Urinary Bladder Calculi'] | 19,362,731 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D03.383.931'], ['C12.777.829.720', 'C12.777.967.500.925', 'C13.351.968.829.521', 'C13.351.968.967.500.925', 'C23.300.175.850.875']] | ['Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Rates of symptom reporting following traumatic brain injury. | This study examines rates of reporting of new or worse post-traumatic symptoms for patients with a broad range of injury severity at 1 month and 1 year after traumatic brain injury (TBI), as compared with those whose injury spared the head, and assesses variables related to symptom reporting at 1 year post-injury. Seve... | ['Adult', 'Brain Injuries', 'Diagnosis, Differential', 'Female', 'Humans', 'Injury Severity Score', 'Male', 'Prevalence'] | 20,188,017 | [['M01.060.116'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.800.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High failure rate of bulk femoral head allografts in total hip acetabular reconstructions at 10 years. | The authors evaluated the radiographic appearance and functional performance of 30 cemented total hip arthroplasty acetabular reconstructions in 28 patients in whom bulk, weight-bearing, femoral head allografts were used to augment severe acetabular bone deficiency with a mean follow-up period of 10 years (range, 8-13.... | ['Acetabulum', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Femur Head', 'Graft Survival', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Reoperation', 'Time Factors', 'Treatment Outcome'] | 8,409,985 | [['A02.835.232.043.825.108'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A02.835.232.043.150.343'], ['G12.875.545.340'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.690'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cavernous hemangioma of the parotid gland. | In adults, hemangioma is a rare presentation of a parotid mass. In this report, we present a case of a 40-year-old lady complaining of a swelling in the right inferior parotid region. Imaging studies revealed a cystic lesion of the right parotid gland. Fine needle aspiration cytology was not significantly helpful in re... | ['Adult', 'Biopsy, Fine-Needle', 'Female', 'Hemangioma, Cavernous', 'Humans', 'Parotid Gland', 'Parotid Neoplasms'] | 17,966,740 | [['M01.060.116'], ['E01.370.225.500.384.100.119.500', 'E01.370.225.998.054.119.500', 'E01.370.388.100.100.500', 'E04.074.119.500', 'E04.665.100.500', 'E05.200.500.384.100.119.500', 'E05.200.998.054.119.500', 'E05.242.384.100.119.500'], ['C04.557.645.375.385', 'C14.907.454.385', 'C15.378.463.515.385'], ['B01.050.150.900... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sterilization and wear-related failure in first- and second-generation press-fit condylar total knee arthroplasty. | UNLABELLED: We compared the incidence of wear-related failures between two large cohorts of patients undergoing total knee arthroplasty implanted with identical modular tibial trays and polyethylene inserts sterilized by different methods. A total of 1183 second-generation press-fit condylar prostheses having inserts p... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anaerobiosis', 'Arthroplasty, Replacement, Knee', 'Awards and Prizes', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Osteolysis', 'Oxygen', 'Polyethylene', 'Prosthesis Design', 'Prosthesis Failure', 'Risk Factors', 'Sterili... | 18,062,044 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.062', 'G03.078'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['K01.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.31... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. | EphA2 is a receptor tyrosine kinase (RTK) that triggers keratinocyte differentiation upon activation and subsequent downregulation by ephrin-A1 ligand. The objective of this study was to determine whether the EphA2/ephrin-A1 signaling axis was altered in psoriasis, an inflammatory skin condition in which keratinocyte d... | ['Biopsy', 'Case-Control Studies', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Cytokines', 'Ephrin-A1', 'Epidermal Growth Factor', 'Epidermis', 'Humans', 'Keratinocytes', 'Psoriasis', 'Receptor, EphA2', 'Signal Transduction'] | 23,190,894 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D12.644.276.374', 'D12.776.46... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Autologous hematopoietic stem cell transplantation followed by oral bexarotene in a patient with advanced mycosis fungoides]. | We describe the case of a 17-year-old patient with rapidly progressing and aggressive mycosis fungoides, with multiple cutaneous tumors and large cell transformation. She was initially treated with 3 cycles of high-dose chemotherapy with mega-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) without res... | ['Adolescent', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Bexarotene', 'Busulfan', 'Cisplatin', 'Combined Modality Therapy', 'Cyclophosphamide', 'Cytarabine', 'Doxorubicin', 'Etoposide', 'Female', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Mechlorethamine', 'Methylprednisolone... | 18,682,170 | [['M01.060.057'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.455.426.559.847.638.960.423', 'D04.615.638.960.423'], ['D02.033.455.125.125', 'D02.455.326.146.100.050.500.100', 'D02.886.645.600.055.050.510.100'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['D02.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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