Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epistasis among adaptive mutations in deer mouse hemoglobin. | Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in deer mouse hemoglobin ... | ['Adaptation, Biological', 'Alleles', 'Animals', 'Epistasis, Genetic', 'Evolution, Molecular', 'Exons', 'Genetic Variation', 'Hemoglobins', 'Hydrogen Bonding', 'Mutation', 'Oxygen', 'Peromyscus', 'Polymorphism, Genetic', 'Protein Structure, Secondary', 'alpha-Globins', 'beta-Globins'] | 23,766,324 | [['G16.012'], ['G05.360.340.024.340.030'], ['B01.050'], ['G05.308.207'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.137.232'], ['G05.365'], ['D12.776.124.400', 'D12.776.422.316.762'], ['G02.282'], ['G05.365.590'], ['D01.268.185.550', 'D01.362.670'], ['B01.050.150.900.649.313.992.635.075.500.510'], ['G05.365.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acoustics of a standing wave tank for studying the hearing capacity of fish. | In a standing wave tank responses of fish to sound stimuli used to investigate the hearing capacity of fish may perhaps be affected by unintended stimulation of the lateral line. Uniform oscillatory water flow patterns do not stimulate the lateral line. Departures from uniformity were derived from measurements to acous... | ['Acoustics', 'Animals', 'Fishes', 'Hearing', 'Mathematics', 'Pitch Perception'] | 4,019,904 | [['H01.671.031'], ['B01.050'], ['B01.050.150.900.493'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['H01.548'], ['F02.463.593.071.700', 'G07.888.125.700']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Long non‑coding RNA DLX6‑AS1 promotes proliferation by acting as a ceRNA targeting miR‑199a in cervical cancer. | Emerging evidence has revealed significant roles for long noncoding RNA (lncRNA) in various biological processes, including cell proliferation, apoptosis and invasion. The lncRNA distal‑less homeobox 6 antisense 1 (DLX6‑AS1) has been reported to serve as a vital oncogene during tumorigenesis and progression. However, t... | ['Adult', 'Apoptosis', 'Carcinogenesis', 'Cell Line, Tumor', 'Cell Proliferation', 'Female', 'Gene Expression Regulation, Neoplastic', 'HeLa Cells', 'Homeodomain Proteins', 'Humans', 'MicroRNAs', 'Middle Aged', 'Neoplasm Invasiveness', 'RNA', 'RNA, Long Noncoding', 'Up-Regulation', 'Uterine Cervical Neoplasms'] | 30,535,431 | [['M01.060.116'], ['G04.146.954.035'], ['C04.697.098', 'C23.550.727.098'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.308.370'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. | We examined the molecular, structural, and functional consequences on cone photoreceptors of the neural retinal leucine zipper knockout (Nrl(-/-)) mice when only one allele of retinal degeneration slow (Rds) is present (Rds(+/-)/Nrl(-/-)). Quantitative RT-PCR and immunoblot analysis were used to assess the expression l... | ['Animals', 'Animals, Newborn', 'Basic-Leucine Zipper Transcription Factors', 'Electroretinography', 'Eye Proteins', 'Gene Expression Regulation', 'Light', 'Mice', 'Mice, Knockout', 'Microscopy, Electron, Transmission', 'Nuclear Proteins', 'RNA-Binding Proteins', 'Retina', 'Retinal Cone Photoreceptor Cells', 'Retinal D... | 17,722,028 | [['B01.050'], ['B01.050.050.282'], ['D12.776.260.108', 'D12.776.930.127'], ['E01.370.380.225', 'E01.370.405.270'], ['D12.776.306'], ['G05.308'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Utility of Neutrophil-Lymphocyte Ratio in Predicting Troponin Elevation in the Emergency Department Setting. | There is little data regarding the diagnostic ability of neutrophil-lymphocyte ratio (NLR) in acute coronary syndrome. Therefore, we aimed to assess the predictive value of NLR in the discrimination of troponin-positive patients. We enrolled 244 patients (mean age 61.3 ± 11.7 years, 70.5% male) who presented to the eme... | ['Acute Coronary Syndrome', 'Aged', 'Biomarkers', 'Emergency Service, Hospital', 'Female', 'Humans', 'Lymphocyte Count', 'Male', 'Middle Aged', 'Troponin'] | 24,431,379 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['D23.101'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.195.107.595.500', 'E01.370.225.625.107.595.500', 'E05.200.500.195.107.595.500', 'E05.200.625.107.595.50... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Eight short tandem repeats (STR) frequencies for descendants from Terena indigenous Brazilian group. | POPULATION: descendants from Terenas an indigenous group. | ['Brazil', 'DNA Fingerprinting', 'Ethnic Groups', 'Gene Frequency', 'Genetics, Population', 'Humans', 'Tandem Repeat Sequences'] | 15,027,569 | [['Z01.107.757.176'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['M01.686.754', 'N01.224.317'], ['G05.330'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.708.800', 'G05.360.080.708.800', 'G05.360.340.024.850']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Longitudinal associations of maternal depression and adolescents' depression and behaviors: Moderation by maltreatment and sex. | This study explored the longitudinal relationships among maternal depressive symptoms, children's depressive symptoms, aggression, and rule breaking and tested the moderating effects of maltreatment and child sex. A sample of 175 biological mother-child dyads (86 maltreated and 89 comparison) were seen at three time po... | ['Adolescent', 'Adolescent Behavior', 'Adult', 'Aggression', 'Child', 'Child Abuse', 'Depressive Disorder', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Mother-Child Relations', 'Mothers', 'Sex Factors', 'Young Adult'] | 29,658,761 | [['M01.060.057'], ['F01.145.022'], ['M01.060.116'], ['F01.145.126.125', 'F01.145.813.045'], ['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
["Closed" curative surgery and laser therapy in the early postoperative period in patients with chronic suppurative epimesotympanitis]. | Taking into account the severity of middle ear pathology and the Eustachian tube function, three methods of "closed" surgery were applied to 132 patients with chronic purulent-caries epimesotympanitis. On post-operation days 2-15, 85 patients were exposed to internal or external laser therapy. As a result, the post-ope... | ['Adolescent', 'Adult', 'Chronic Disease', 'Female', 'Humans', 'Laser Therapy', 'Male', 'Middle Aged', 'Otitis Media, Suppurative', 'Postoperative Care', 'Radiotherapy Dosage', 'Time Factors', 'Tympanoplasty'] | 1,755,181 | [['M01.060.057'], ['M01.060.116'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['C01.830.694', 'C09.218.705.663.680'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['E02.815.639'], ['G01.910.857'], ['E04.580.450.873']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mg2+-dependent/poly(ADP-ribose)-sensitive endonuclease. | A novel endonuclease from adult hen liver nuclei has been purified to a homogeneous state through salt extraction, ammonium sulfate fractionation, gel filtration, acetone fractionation, and successive chromatography of 1) hydroxyapatite and DNA Sepharose and 2) hydroxyapatite and isoelectric focusing. The endonuclease ... | ['Animals', 'Cations, Divalent', 'Chickens', 'DNA', 'Endonucleases', 'Hydrogen-Ion Concentration', 'Liver', 'Magnesium', 'Molecular Weight', 'Nucleic Acid Denaturation', 'Nucleoside Diphosphate Sugars', 'Poly Adenosine Diphosphate Ribose'] | 6,307,995 | [['B01.050'], ['D01.248.497.300.333'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D13.444.308'], ['D08.811.277.352.355'], ['G02.300'], ['A03.620'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['G02.494'], ['E05.393.640', 'G02.111.603', 'G05.627'], ['D09.408.620.569', 'D13.695.201.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The evolution of selfing is accompanied by reduced efficacy of selection and purging of deleterious mutations. | The transition from outcrossing to selfing is predicted to reduce the genome-wide efficacy of selection because of the lower effective population size (Ne) that accompanies this change in mating system. However, strongly recessive deleterious mutations exposed in the homozygous backgrounds of selfers should be under st... | ['Eichhornia', 'Evolution, Molecular', 'Models, Genetic', 'Mutation', 'Polymorphism, Genetic', 'Selection, Genetic', 'Self-Fertilization'] | 25,552,275 | [['B01.650.940.800.575.912.250.827.500'], ['G05.045.250', 'G16.075.250'], ['E05.599.395.397'], ['G05.365.590'], ['G05.365.795'], ['G05.783'], ['G05.090.403.590', 'G08.686.784.277.560', 'G15.830']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physico-chemical properties of the new antibronchospastic agent isbufylline. | Physico-chemical properties, i.e. elemental analysis, spectra (NMR, MS, IR, UV), X-ray crystal structure, solubilities, partition coefficient, melting point, HPLC, GC, and data about purity and stability of 1,3-dimethyl-7-isobutyl xanthine (isbufylline, TE/06, CAS 90162-60-0), a new drug with antibronchospastic propert... | ['1-Methyl-3-isobutylxanthine', 'Bronchodilator Agents', 'Chemical Phenomena', 'Chemistry, Physical', 'Chromatography, Gas', 'Chromatography, High Pressure Liquid', 'Magnetic Resonance Spectroscopy', 'Powders', 'Solubility', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ultraviolet', 'X-Ray Diffraction'] | 1,705,424 | [['D03.633.100.759.758.824.751.500'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['G02'], ['H01.181.529'], ['E05.196.181.349'], ['E05.196.181.400.300'], ['E05.196.867.519'], ['D26.255.779'], ['G02.805'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['E05.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondrial matR sequences help to resolve deep phylogenetic relationships in rosids. | BACKGROUND: Rosids are a major clade in the angiosperms containing 13 orders and about one-third of angiosperm species. Recent molecular analyses recognized two major groups (i.e., fabids with seven orders and malvids with three orders). However, phylogenetic relationships within the two groups and among fabids, malvid... | ['Base Sequence', 'DNA, Mitochondrial', 'DNA, Plant', 'Endoribonucleases', 'Evolution, Molecular', 'Genes, Plant', 'Genetic Variation', 'Likelihood Functions', 'Magnoliopsida', 'Molecular Sequence Data', 'Nucleotidyltransferases', 'Phylogeny', 'Plastids', 'Ribulose-Bisphosphate Carboxylase', 'Sequence Alignment', 'Sequ... | 17,996,110 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.283.225'], ['D13.444.308.435'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.365'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Clinicopathological Significance of Nerves in Esophageal Cancer. | Nerves are emerging promoters of cancer progression, but the innervation of esophageal cancer and its clinicopathologic significance remain unclear. In this study, nerves were analyzed by immunohistochemistry in a cohort of 260 esophageal cancers, including 40 matched lymph node metastases and 137 normal adjacent esoph... | ['Adult', 'Aged', 'Esophageal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Nerve Growth Factor', 'Peripheral Nerves', 'Tumor Microenvironment'] | 32,479,822 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'], ['D12.644.276.860.437', 'D12.776.467.860.437', 'D12.776.631.600.437', 'D23... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Disorganization of mitosis in HeLa cells by deuterium oxide. | We assessed, by light and electron microscopy, the influence of deuterium oxide on the dynamics of mitosis and on the morphology of the mitotic apparatus in HeLa cells grown in vitro. A 2-h incubation of HeLa monolayers with low concentrations of D2O (1%-25%) in the medium increased the frequency of multipolar division... | ['Chromatin', 'Chromosomes', 'Deuterium', 'Deuterium Oxide', 'HeLa Cells', 'Humans', 'Interphase', 'Microscopy, Electron', 'Microtubules', 'Mitosis', 'Spindle Apparatus', 'Water'] | 2,560,715 | [['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['D01.045.250.875.200', 'D01.248.497.158.459.650.200', 'D01.268.406.500.250', 'D01.362.340.500.250'], ['A11.251.210.190.40... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pituitary apoplexy, therapeutic assessment. | The management of pituitary apoplexy with reference to both diagnosis and operative sequelae remains a major challenge. Acute onset of retro-orbital headache in association with visual loss and ophthalmoplegia are the cardinal symptoms; however, obtundation and signs of subarachnoid hemorrhage also may be present. Good... | ['Adult', 'Female', 'Headache', 'Humans', 'Male', 'Middle Aged', 'Ophthalmoplegia', 'Pituitary Diseases', 'Postoperative Complications', 'Subarachnoid Hemorrhage', 'Syndrome', 'Vision Disorders'] | 1,032,116 | [['M01.060.116'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.292.562.750', 'C10.597.622.447', 'C11.590.472', 'C23.888.592.636.447'], ['C10.228.140.617.738', 'C19.700'], ['C23.550.767'], ['C10.228.140.300.535.800', 'C14.907.253.573.800', 'C23.550.414.913.850'], [... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro susceptibility of pseudomonas to four beta-lactamantibiotics (ampicillin, cephalothin, carbenicillin, piperacillin), to four aminoglycosides (kanamycin, amikacin, gentamicin, tobramycin) and to colimycin. | Of 97 well-defined strains of Pseudomonas, isolated from sputum of patients with cystic fibrosis (CF), the minimum inhibitory concentration (MIC) of several antibiotics was determined with a broth dilution method. The majority of the strains were resistant to ampicillin and cephalothin, moderately susceptible to carben... | ['Amikacin', 'Aminoglycosides', 'Ampicillin', 'Carbenicillin', 'Cephalothin', 'Child', 'Colistin', 'Cystic Fibrosis', 'Gentamicins', 'Humans', 'Kanamycin', 'Microbial Sensitivity Tests', 'Penicillin Resistance', 'Penicillins', 'Pseudomonas', 'Sputum', 'Tobramycin'] | 253,637 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Computerized analysis of activity profiles of beta-lactams]. | This study was designed to compare the in vitro activities of recent cephalosporins and other beta-lactams. One of our objectives was to determine whether the microbiologist could use a single cephalosporin for routine antibiotic sensitivity testing. All the strains studied were recovered from outpatients. Sensitivity ... | ['Anti-Bacterial Agents', 'Bacteria', 'Cephalosporins', 'Computers', 'Drug Resistance, Microbial', 'Enterobacteriaceae', 'Enterococcus faecalis', 'Microbial Sensitivity Tests', 'Pseudomonas aeruginosa', 'Staphylococcus aureus', 'Streptococcus'] | 3,937,131 | [['D27.505.954.122.085'], ['B03'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['L01.224.230.260'], ['G06.225', 'G07.690.773.984.269'], ['B03.440.450.425', 'B03.660.250.150'], ['B03.353.750.250.250.280', 'B03.510.550.250.250.280'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Transglomerular cationic macromolecular flux is mediated by a convection-binding mechanism. | Glomerular polyanion function was explored using charged and neutral [3H]dextrans in the multiple indicator-dilution experiment. Anesthetized dogs received an intrarenal bolus of 125I-labeled albumin (plasma reference), [14C]inulin (glomerular reference) and [3H]dextran (test solute), followed by rapid serial sampling ... | ['Animals', 'Biomechanical Phenomena', 'Cations', 'Dextrans', 'Dogs', 'In Vitro Techniques', 'Indicator Dilution Techniques', 'Kidney Glomerulus', 'Macromolecular Substances', 'Male', 'Microinjections', 'Models, Biological', 'Protamines', 'Rats', 'Rats, Inbred Strains'] | 2,470,261 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['D01.248.497.300'], ['D05.750.078.562.272', 'D09.698.365.272'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.481'], ['E05.484'], ['A05.810.453.324.359', 'A05.810.453.736.520'], ['D05'], ['E02.319.267.530.690', 'E05.591.570'], ['E05.599.395'], ['D12.776.660.750', 'D12... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene. | In this study, we report the expression and genomic structure of the gene encoding human suppressor of cytokine signaling 6 (SOCS6), and the characterization of the functional promoter region. The human SOCS6 gene, spanning 40 kb on chromosome 18q22.2, is composed of two exons separated by an intron of 35 kb. Two trans... | ["5' Flanking Region", 'Animals', 'Cell Line', 'Chromosomes, Human, Pair 18', 'Conserved Sequence', 'Exons', 'Gene Expression Regulation', 'Genome, Human', 'Humans', 'Introns', 'Molecular Sequence Data', 'Promoter Regions, Genetic', 'Suppressor of Cytokine Signaling Proteins'] | 19,716,864 | [['G05.360.340.024.220.282', 'G05.360.340.024.340.137.295'], ['B01.050'], ['A11.251.210'], ['A11.284.187.520.300.415.430', 'G05.360.162.520.300.415.430'], ['G02.111.570.580'], ['G05.360.340.024.340.137.232'], ['G05.308'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', ... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Predictive indicators for thyroid cartilage involvement in carcinoma of the larynx seen on spiral computed tomography scans. | OBJECTIVES: Recent studies have shown that the spiral computed tomography (CT) scan is a sensitive imaging modality for predicting neoplastic invasion of thyroid cartilage. The objectives of our study were: to assess the accuracy of pre-operative spiral CT in predicting thyroid cartilage involvement in patients with ca... | ['Carcinoma', 'Humans', 'Laryngeal Neoplasms', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Prognosis', 'Retrospective Studies', 'Sensitivity and Specificity', 'Thyroid Cartilage', 'Tomography, Spiral Computed', 'Wales'] | 17,038,232 | [['C04.557.470.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.481', 'C08.360.369', 'C08.785.481', 'C09.400.369', 'C09.647.481'], ['C04.697.645', 'C23.550.727.645'], ['E01.789.625'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Expression of tobacco necrosis virus open reading frames 1 and 2 is sufficient for the replication of satellite tobacco necrosis virus. | Tobacco necrosis virus (TNV) is a small icosahedral plant virus which is often associated with satellite viruses. The genomic RNA of TNV contains six open reading frames (ORFs), of which ORFs 1 and 2 are thought to encode the viral polymerase. We demonstrate that tobacco protoplasts transfected with a vector containing... | ['DNA-Directed RNA Polymerases', 'Gene Expression Regulation, Viral', 'Genes, Viral', 'Open Reading Frames', 'Plant Viruses', 'Plants, Toxic', 'Satellite Viruses', 'Tobacco', 'Viral Structural Proteins', 'Virus Replication'] | 7,676,634 | [['D08.811.913.696.445.735.270'], ['G05.308.385'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['B04.715'], ['B01.650.660'], ['B04.265.658'], ['B01.650.940.800.575.912.250.908.500.900'], ['D12.776.964.970'], ['G06.920.925... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes. | N-Me-anthranylaldoximes possess a hydrogen-bonded pseudocyclic A' ring in place of the typical phenolic A-ring that is characteristic of most estrogen receptor (ER) ligands. We have investigated the role played by substituents introduced into either one or both of the peripheral 3- and 4-phenyl rings in modulating ER b... | ['Benzene Derivatives', 'Binding Sites', 'Binding, Competitive', 'Estrogen Receptor alpha', 'Estrogen Receptor beta', 'Humans', 'Ligands', 'Models, Molecular', 'Molecular Conformation', 'Oximes', 'Radioligand Assay', 'Stereoisomerism', 'Structure-Activity Relationship', 'Thermodynamics'] | 16,884,312 | [['D02.455.426.559.389'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D12.776.826.750.350.174'], ['D12.776.826.750.350.262'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['E05.599.595'], ['G02.111.570.820'], ['D02.092.570.665'], ['E01.370.225.985', 'E01.370.37... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endocardial cushion defects: an anatomical study of 54 specimens. | An anatomical study of 54 specimens with endocardial cushion defect is described. The material was divided into two groups, according to the morphology and attachments of the anterior component of the anteroseptal mitral leaflet. We suggest that there is no divided or undivided anterior common leaflet. There are always... | ['Ductus Arteriosus, Patent', 'Endocardium', 'Fetal Heart', 'Heart Septal Defects', 'Heart Septal Defects, Atrial', 'Heart Septal Defects, Ventricular', 'Humans', 'Mitral Valve', 'Papillary Muscles', 'Tricuspid Valve'] | 973,890 | [['C14.240.400.340', 'C14.280.400.340', 'C16.131.240.400.340'], ['A07.541.207'], ['A07.541.278', 'A16.378.303'], ['C14.240.400.560', 'C14.280.400.560', 'C16.131.240.400.560'], ['C14.240.400.560.375', 'C14.280.400.560.375', 'C16.131.240.400.560.375'], ['C14.240.400.560.540', 'C14.280.400.560.540', 'C16.131.240.400.560.5... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A resistance exercise set for a total body workout for adults with intellectual disabilities, a pilot study. | BACKGROUND: Resistance training has beneficial effects on fitness levels, cardiovascular disease risk, risk of sarcopenia and on performing activities of daily living. The focus of this study is to design a total body resistance exercise set for adults with intellectual disabilities (RESID) with minimal equipment requi... | ['Adult', 'Feasibility Studies', 'Female', 'Humans', 'Intellectual Disability', 'Male', 'Outcome and Process Assessment, Health Care', 'Pilot Projects', 'Resistance Training', 'Young Adult'] | 30,536,559 | [['M01.060.116'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['N04.761.559', 'N05.715.360.575'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. | The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 ? 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging bet... | ['Administration, Cutaneous', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Chemistry, Pharmaceutical', 'Cholesterol', 'Diclofenac', 'Excipients', 'Male', 'Phosphatidylcholines', 'Rats, Sprague-Dawley', 'Skin', 'Skin Absorption'] | 24,490,793 | [['E02.319.267.120.060'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['H01.158.703.007', 'H01.181.466'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D02.241.223.601.210'], ['D26.650.700.419', 'D27.720.744.770.419'], ['D10.570.755.375.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Visual localisation in patients with occipital infarction. | Visually directed pointing has been examined in a group of patients with occipital lobe infarction and in an age-matched control group. The visual field ipsilateral to the infarct showed normal localisation; there was no evidence that right sided infarction produced a bilateral disturbance. In quadrantanopia the spared... | ['Cerebral Infarction', 'Dominance, Cerebral', 'Female', 'Hemianopsia', 'Humans', 'Male', 'Middle Aged', 'Occipital Lobe', 'Psychomotor Performance', 'Visual Fields'] | 6,707,654 | [['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['F02.830.297', 'G11.561.225'], ['C10.597.751.941.512', 'C11.966.075.500', 'C23.888.592.763.941.512'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection. | INTRODUCTION: Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO). It was reported that colonic methane production is far more frequent in cystic fibrosis (CF) patients than in other subjects. Therefore, measuring exclusively hydrogen in the d... | ['Adolescent', 'Breath Tests', 'Child', 'Child, Preschool', 'Cystic Fibrosis', 'Gastrointestinal Diseases', 'Humans', 'Hydrogen', 'Intestine, Small', 'Methane'] | 19,997,657 | [['M01.060.057'], ['E01.370.100'], ['M01.060.406'], ['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['C06.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.406', 'D01.362.340'], ['A03.556.124.684'], ['D02.455.326.146.571']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cadaveric Analysis of Posterior Pharyngoesophageal Wall Thickness: Implications for Anterior Cervical Spine Surgery. | STUDY DESIGN: A cadaveric study.OBJECTIVE: To investigate possible variations of posterior pharyngoesophageal (PE) wall thickness in the horizontal plane and their implications for anterior spine surgery.SUMMARY OF BACKGROUND DATA: Lower cervical levels (C5-7) are most commonly involved in cases of PE injury, and PE wa... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Screws', 'Cadaver', 'Cervical Vertebrae', 'Cross-Sectional Studies', 'Esophagus', 'Female', 'Humans', 'Internal Fixators', 'Male', 'Middle Aged', 'Pharynx', 'Retrospective Studies'] | 26,571,171 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['C23.550.260.224'], ['A02.835.232.834.151'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A03.556.875.500'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
American Indian perceptions of colorectal cancer screening: viewpoints from adults under age 50. | Colorectal cancer (CRC) mortality rates have decreased in the general US population; however, CRC mortality rates are increasing among American Indians (AI). AI CRC screening rates remain low when compared to other ethnic groups. Our team investigated CRC screening education prior to recommended age for screening to be... | ['Adult', 'Colorectal Neoplasms', 'Early Detection of Cancer', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Indians, North American', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Perception'] | 23,086,536 | [['M01.060.116'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E01.390.500'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.600'], ['M01.060.116.630'], ['I02.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. | In the yeast Saccharomyces cerevisiae, the products of at least 14 genes are involved specifically in vesicular transport from the Golgi apparatus to the plasma membrane. Two of these genes, SEC8 and SEC15, encode components of a 1-2-million D multi-subunit complex that is found in the cytoplasm and associated with the... | ['Amino Acid Sequence', 'Carrier Proteins', 'Chromatography, Affinity', 'Fluorescent Antibody Technique', 'Fungal Proteins', 'GTP-Binding Proteins', 'Molecular Sequence Data', 'Molecular Weight', 'Mutagenesis, Site-Directed', 'Precipitin Tests', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Vesicula... | 7,615,633 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.157'], ['E05.196.181.400.170'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D12.776.354'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['L01.453.245.667'], ['G02.494'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regional dose response to pulmonary irradiation using a manual method. | PURPOSE: To better understand the dose dependence of radiation therapy (RT)-induced changes in regional lung perfusion and tissue density, using a manual method to reduce inaccuracies that might be present in previously described automated methods.MATERIALS AND METHODS: Patients who were to receive RT for tumors in and... | ['Dose-Response Relationship, Radiation', 'Humans', 'Lung', 'Lung Neoplasms', 'Models, Theoretical', 'Prospective Studies', 'Radiation Injuries', 'Radiotherapy Dosage', 'Thoracic Neoplasms', 'Tomography, Emission-Computed, Single-Photon', 'Tomography, X-Ray Computed'] | 9,756,172 | [['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E05.599'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phosphorescent platinum/palladium coproporphyrins for time-resolved luminescence microscopy. | Streptavidin and antibodies were labeled with phosphorescent platinum and palladium coproporphyrin. The optimal conjugates were selected on the basis of spectroscopic analysis (molar extinction coefficient, quantum yield, lifetime) and using ELISA assays to determine the retention of biological activity and immunospeci... | ['Acyltransferases', 'Animals', 'Coproporphyrins', 'Deoxyuracil Nucleotides', 'Glucagon', 'Glutathione Transferase', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization', 'Liver', 'Male', 'Metalloporphyrins', 'Microscopy, Fluorescence', 'Pancreas', 'Plants', 'Prostate', 'Prostate-Specific Antigen', 'RNA, Ribosomal... | 9,889,254 | [['D08.811.913.050'], ['B01.050'], ['D03.383.129.578.840.500.250', 'D03.633.400.909.500.250', 'D04.345.783.500.250', 'D23.767.727.250'], ['D03.383.742.686.850.210', 'D13.695.201.200', 'D13.695.740.850.210'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of N-Acetyl-d-glucosamine from Mycelial Waste by a Combination of Bacterial Chitinases and an Insect N-Acetyl-d-glucosaminidase. | N-Acetyl-d-glucosamine (GlcNAc) has great potential to be used as a food additive and medicine. The enzymatic degradation of chitin-containing biomass for producing GlcNAc is an eco-friendly approach but suffers from a high cost. The economical efficiency can be improved by both optimizing the member and ratio of the c... | ['Acetylglucosamine', 'Animals', 'Aspergillus niger', 'Bacterial Proteins', 'Chitinases', 'Hexosaminidases', 'Insect Proteins', 'Moths', 'Mycelium', 'Serratia marcescens', 'Waste Products'] | 27,546,481 | [['D09.067.342.531.050'], ['B01.050'], ['B01.300.381.081.450'], ['D12.776.097'], ['D08.811.277.450.207'], ['D08.811.277.450.483'], ['D12.776.093.500'], ['B01.050.500.131.617.720.500.500.937.650'], ['A19.687'], ['B03.440.450.425.814.664', 'B03.660.250.150.720.500'], ['D20.944', 'N06.850.460.710']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A properly conducted trial of a ventouse can prevent unexpected failure of instrumental delivery. | A retrospective study over a 5-year period reviewed 71 unexpected failures of instrumental delivery and compared them with a group of 21 trials of ventouse to identify causes for failure and their impact on neonatal outcome. There was a statistically significant difference between the two groups in terms of pre-applica... | ['Extraction, Obstetrical', 'Female', 'Humans', 'Infant Mortality', 'Infant, Newborn', 'Pregnancy', 'Retrospective Studies', 'Vacuum Extraction, Obstetrical'] | 2,024,210 | [['E04.520.252.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.505.400.975.550.475', 'N06.850.520.308.985.550.475'], ['M01.060.703.520'], ['G08.686.784.769'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.71... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanisms of Trypanosoma cruzi-induced down-regulation of lymphocyte function. Inhibition of transcription and expression of IL-2 receptor gamma (p64IL-2R) and beta (p70IL-2R) chain molecules in activated normal human lymphocytes. | Acute infection with Trypanosoma cruzi, the agent of Chagas' disease, is accompanied by multiple manifestations of immunosuppression, and this parasite has been shown to inhibit T and B lymphocyte functions in vitro through a mechanism involving impaired membrane expression of at least the p55IL-2R (IL-2R alpha) and p7... | ['Animals', 'Down-Regulation', 'Gene Expression Regulation', 'Humans', 'Immunosuppressive Agents', 'Lymphocyte Activation', 'Lymphocytes', 'Phytohemagglutinins', 'Receptors, Interleukin-2', 'Transcription, Genetic', 'Trypanosoma cruzi'] | 8,621,925 | [['B01.050'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of gamma radiation on the early developmental stages of Zebrafish (Danio rerio). | The zebrafish is gaining importance as a popular vertebrate model organism and is widely employed in ecotoxicological studies, especially for the biomonitoring of pollution in water bodies. There is limited data on the genetic mechanisms governing the adverse health effects in regards to an early developmental exposure... | ['Animals', 'Comet Assay', 'DNA Damage', 'Dose-Response Relationship, Radiation', 'Embryo, Nonmammalian', 'Gamma Rays', 'Gene Expression Regulation, Developmental', 'Real-Time Polymerase Chain Reaction', 'Zebrafish'] | 28,395,206 | [['B01.050'], ['E05.196.401.153.150', 'E05.301.300.100.150', 'E05.393.560.150', 'E05.940.560.150'], ['G05.200'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['A13.350', 'A16.331'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['G05.308.310'],... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genome-wide DNA methylation in suicide victims revealing impact on gene expression. | BACKGROUND: Suicidal behavior is a multifactorial, polygenic state that affects millions worldwide. It is a result of interplay between hereditary and environmental factors, tied together by epigenetics. Despite vast knowledge on suicidality complete mechanism and factors leading to suicide are unknown. However there i... | ['Adult', 'Brain', 'Cerebral Cortex', 'DNA', 'DNA Methylation', 'DNA-Binding Proteins', 'Epigenesis, Genetic', 'Epigenomics', 'Female', 'Gene Expression', 'Hippocampus', 'Humans', 'Male', 'Promoter Regions, Genetic', 'Self-Injurious Behavior', 'Suicidal Ideation', 'Suicide', 'Temporal Lobe', 'Transcription Factors'] | 31,103,807 | [['M01.060.116'], ['A08.186.211'], ['A08.186.211.200.885.287.500'], ['D13.444.308'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D12.776.260'], ['G05.308.203'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['G05.297'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
Chronic heart failure in heart transplant recipients: Presenting features and outcome. | BACKGROUND: The ageing graft frequently shows coronary lesions and a restrictive physiology.AIMS: To determine the presenting features and outcome of chronic heart failure in heart transplant recipients.METHODS: In this cohort study, we compared 44 consecutive heart transplant recipients who developed chronic heart fai... | ['Cohort Studies', 'Female', 'Heart Failure', 'Heart Transplantation', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Treatment Outcome'] | 26,993,361 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C14.280.434'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An investigation of replantation of traumatically avulsed permanent incisor teeth. | The success of treatment of 46 replanted, avulsed permanent incisors in 36 children was investigated in relation to some of the factors which have been reported to affect prognosis. Treatment was considered to have been successful if the tooth was still present in the mouth and required no further treatment. If more tr... | ['Adolescent', 'Animals', 'Chi-Square Distribution', 'Child', 'Dental Pulp Diseases', 'Female', 'Humans', 'Incisor', 'Male', 'Milk', 'Prognosis', 'Retrospective Studies', 'Root Resorption', 'Saliva', 'Sodium Chloride', 'Time Factors', 'Tooth Avulsion', 'Tooth Replantation', 'Treatment Outcome'] | 1,736,945 | [['M01.060.057'], ['B01.050'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['C07.793.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J0... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The German Sea Rescue Service (SAR). | The German Sea Rescue Service (GSRS) history, organisation and operations are presented. The institution was founded in 1865 to provide sea rescue services for the German coasts in the North Sea and in the Baltic Sea. Its fleet counts 61 vessels based in 54 stations of the service. In 2001, the rescue crafts were calle... | ['Aircraft', 'Emergency Medical Services', 'Germany', 'Humans', 'Naval Medicine', 'Rescue Work', 'Ships', 'Transportation of Patients'] | 12,608,596 | [['J01.937.285.100'], ['N02.421.297'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.560'], ['N06.230.100.350'], ['J01.937.817'], ['E02.365.839', 'N02.421.297.879']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
[Three cases in which CR was obtained in residual metastatic lesions by intrahepatic arterial infusion after resection of hepatic metastases from colorectal carcinoma]. | We report three cases in which CR was maintained after infusion (WHF) was performed for residual metastatic lesions following resection of hepatic metastases from colorectal cancer. (Case 1) A 55-year-old female with sigmoidal cancer and hepatic metastases, H2 (4 lesions). Right lobectomy and partial resection of the l... | ['Aged', 'Antimetabolites, Antineoplastic', 'Colorectal Neoplasms', 'Combined Modality Therapy', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Hepatectomy', 'Hepatic Artery', 'Humans', 'Infusions, Intra-Arterial', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Remission Induction'] | 11,086,455 | [['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E02.186'], ['E02.319.283'], ['D03.383.742.698.875.404'], ['E04.210.556'], ['A07.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Surgical resection for isolated myeloid sarcoma arising from a rib. | We report on a rare manifestation of myeloid sarcoma with chronic myelogenous leukemia. The neoplasm arising from a rib showed osteolytic changes and infiltrated the surrounding muscles. We resected the lesion to relieve chest pain caused by pathologic rib fractures. The patient has continued receiving systemic therapy... | ['Aged', 'Bone Neoplasms', 'Female', 'Humans', 'Ribs', 'Sarcoma, Myeloid'] | 23,098,984 | [['M01.060.116.100'], ['C04.588.149', 'C05.116.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.570.500'], ['C04.557.337.539.775', 'C04.557.450.795.853']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Density-based diamagnetic separation: devices for detecting binding events and for collecting unlabeled diamagnetic particles in paramagnetic solutions. | This paper describes the fabrication of a fluidic device for detecting and separating diamagnetic materials that differ in density. The basis for the separation is the balance of the magnetic and gravitational forces on diamagnetic materials suspended in a paramagnetic medium. The paper demonstrates two applications of... | ['Adhesiveness', 'Calibration', 'Magnetics', 'Metal Nanoparticles', 'Microfluidics', 'Microspheres', 'Polystyrenes', 'Solutions', 'Static Electricity'] | 17,676,819 | [['G02.860.139'], ['E05.978.155'], ['H01.671.493'], ['J01.637.512.600.500'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['E07.565'], ['D02.455.426.559.389.150.750.800.830', 'D05.750.716.579', 'D25.720.716.579', 'J01.637.051.720.716.579'], ['D26.776'], ['G01.358.500.249.820']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Derivation and characterization of a UCP1 reporter human ES cell line. | Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While much insight into brown fat biology has been gained from murine cell lines and models, few resources are available to study human brown fat in vitro, which make... | ['Adipocytes', 'Adipose Tissue, Brown', 'Cell Differentiation', 'Cell Line', 'Humans', 'Mitochondria', 'Obesity', 'Uncoupling Protein 1'] | 29,777,802 | [['A11.329.114'], ['A10.165.114.322'], ['G04.152'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['D12.776.157.530.937.598.500', 'D12... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Non-bacterial thrombotic endocarditis as paraneoplastic manifestation of pulmonary adenocarcinoma]. | Non bacterial thrombotic endocarditis is characterized by the presence of non infected vegetation in aortic or mitral valves associated with systemic arterial emboli. Non-bacterial thrombotic endocarditis is a common complication of neoplastic diseases: adenocarcinoma of the lung, another adenocarcinomas, myeloma, lymp... | ['Adenocarcinoma', 'Adult', 'Endocarditis', 'Fatal Outcome', 'Heart Diseases', 'Humans', 'Lung Neoplasms', 'Male', 'Neoplastic Cells, Circulating', 'Thrombosis'] | 12,613,439 | [['C04.557.470.200.025'], ['M01.060.116'], ['C14.280.282'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A11.642', 'C04.697.650.900'... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Apolipoprotein D expression in metastasic lymph nodes of breast cancer. | BACKGROUND: Apolipoprotein D is a glycoprotein of the human plasma whose functional role remains unclear. On the other hand, this protein is also produced by breast carcinomas and is positively associated with a favorable outcome of patients. However, none study has focused on metastasic lesions.AIM: To analyze apolipo... | ['Apolipoproteins', 'Apolipoproteins D', 'Axilla', 'Biomarkers', 'Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Female', 'Humans', 'Immunohistochemistry', 'Lymph Nodes', 'Lymphatic Metastasis', 'Middle Aged', 'Survival Rate', 'Time Factors'] | 12,678,530 | [['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['D10.532.091.450', 'D12.776.070.400.450', 'D12.776.521.120.450'], ['A01.378.800.090'], ['D23.101'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['B01.050.150.900.649.313... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of cadmium on photosynthetic oxygen evolution from single stomata in Brassica juncea (L.) Czern. | Scanning electrochemical microscopy (SECM) was utilized to investigate photosynthetic oxygen evolution from single stomata in leaves of live Brassica juncea (L.) Czern cultured in nutrient solution to which 0.2 or 0.01 mM CdC12 had been added. The bulk leaf surface serves as an insulator normally; therefore, a typical ... | ['Cadmium', 'Mustard Plant', 'Oxygen', 'Photosynthesis', 'Plant Leaves'] | 19,360,968 | [['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['B01.650.940.800.575.912.250.157.200.500'], ['D01.268.185.550', 'D01.362.670'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['A18.024.812']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chitinase expression in parotid glands of non-obese diabetic mice. | OBJECTIVE: This investigation was a basal study that used a mouse model of xerostomia to identify protein biomarkers of xerostomia in saliva. We identified genes expressed differently in parotid glands from non-obese diabetic mice with diabetes and those from control mice; subsequently, we investigated expression of th... | ['Acinar Cells', 'Animals', 'Chitinases', 'Diabetes Mellitus, Type 1', 'Disease Models, Animal', 'Female', 'Gene Expression', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred NOD', 'Oligonucleotide Array Sequence Analysis', 'Parotid Gland', 'Saliva', 'Salivary Proteins and Peptides', 'Xerostomia'] | 22,309,644 | [['A11.031'], ['B01.050'], ['D08.811.277.450.207'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.52... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of inhibiting survivin expression with antisense oligodeoxynucleotides on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to adriamycin]. | BACKGROUND & OBJECTIVE: Survivin deserves attention as a selective target for cancer therapy because it is silenced in differentiated adult tissues, but is expressed in a variety of human tumors, and is involved in tumorigenesis and chemoresistance. Antisense oligodeoxynucleotides (ASODN) can be used to inhibit the exp... | ['Antibiotics, Antineoplastic', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Caspase 3', 'Cell Line, Tumor', 'Down-Regulation', 'Doxorubicin', 'Drug Resistance, Neoplasm', 'Humans', 'Inhibitor of Apoptosis Proteins', 'Inhibitory Concentration 50', 'Liver Neoplasms', 'Microtubule-Associated Proteins', 'Neoplasm Proteins',... | 16,086,872 | [['D27.505.954.248.106'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210.190', 'A11.251.860.180'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reversal of an aluminum-induced behavioral deficit by administration of deferoxamine. | Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Parti... | ['Alum Compounds', 'Aluminum', 'Animals', 'Avoidance Learning', 'Deferoxamine', 'Dose-Response Relationship, Drug', 'Exploratory Behavior', 'Male', 'Motor Activity', 'Rats', 'Rats, Inbred Strains'] | 2,765,182 | [['D01.056.025', 'D01.875.800.800.850.025'], ['D01.268.557.050', 'D01.552.547.050'], ['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['G07.690.773.875', 'G07.690.936.500'], ['F01.145.387', 'F01.658.370'], ['F01.145.632', 'G11.427.410.698'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gravity-induced absorption changes in Phycomyces blakesleeanus during parabolic flights: first spectral approach in the visible. | Gravity-induced absorption changes as experienced during a series of parabolas on the Airbus 300 Zero-G have been measured previously pointwise on the basis of dual-wavelength spectroscopy. Only the two wavelengths of 460 and 665 nm as generated by light-emitting diodes have been utilised during our first two parabolic... | ['Absorption', 'Cytochromes', 'Electron Transport', 'Energy Metabolism', 'Flavins', 'Gravitation', 'Gravitropism', 'Gravity Sensing', 'Light', 'Mutation', 'Oxidation-Reduction', 'Phycomyces', 'Space Flight', 'Spectroscopy, Fourier Transform Infrared', 'Time Factors', 'Weightlessness'] | 17,180,493 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['D08.244', 'D12.776.422.220'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G03.295'], ['D03.633.100.733.315', 'D03.633.300.507', 'D08.211.474', 'D23.767.405'], ['G01.060.350'], ['G07.345.249.845.400', 'G15.920.400'], ['G11.561.790.255', 'G1... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Non-steroidal and steroidal anti-inflammatory use in the context of orthodontic movement. | The early phase of orthodontic tooth movement involves sterile acute inflammation of the periodontal ligament in response to biomechanical forces. Anti-inflammatories are pharmacologic agents used in medical and dentistry clinics. The aim of the study was to analyse the bone remodelling during orthodontic movement unde... | ['Alveolar Process', 'Animals', 'Anti-Inflammatory Agents', 'Bone Remodeling', 'Collagen', 'Dexamethasone', 'Diclofenac', 'Male', 'Microscopy, Polarization', 'Periodontal Ligament', 'Rats', 'Rats, Wistar', 'Tooth Movement Techniques'] | 21,303,808 | [['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['B01.050'], ['D27.505.954.158'], ['G11.427.213', 'G16.762.150'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D02.241.223.601.210'], ['E01.370.350.515.624', 'E05.595.624'], ['A14.549.167.646... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The lack of relationships between vitamin D3 metabolites and calcium-binding protein in the eggshell gland of laying birds. | The relationship of the metabolism of vitamin D3 and calcium-binding protein (CaBP) to calcium transport by the eggshell gland (ESG) was assessed in chickens. Plasma or ESG 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) and ESG CaBP were no different between periods of ESG inactivity and of shell calcification. A severe dietar... | ['25-Hydroxyvitamin D3 1-alpha-Hydroxylase', 'Animals', 'Calcitriol', 'Calcium-Binding Proteins', 'Chickens', 'Cholecalciferol', 'Egg Shell', 'Exocrine Glands', 'Female', 'Kidney', 'Oviposition', 'S100 Calcium Binding Protein G'] | 6,086,230 | [['D08.244.453.499.500', 'D08.244.453.915.400', 'D08.811.682.690.708.170.493.500', 'D08.811.682.690.708.170.915.400', 'D12.776.422.220.453.499.500', 'D12.776.422.220.453.915.400'], ['B01.050'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surface modification by carboxymethy chitosan via pad-dry-cure method for binding Ag NPs onto cotton fabric. | To obtain durably antimicrobial cotton fabric, carboxymethyl chitosan (CMC) was covalently linked to cotton fibers via an esterification with the cellulose hydroxyl groups, and the silver nanoparticles (Ag NPs) were adhered to the fiber surface by the coordination bonds with the amino groups of CMC. The finished cotton... | ['Anti-Bacterial Agents', 'Chitosan', 'Cotton Fiber', 'Escherichia coli', 'Metal Nanoparticles', 'Staphylococcus aureus', 'Textiles'] | 29,367,162 | [['D27.505.954.122.085'], ['D05.750.078.139.500', 'D09.698.211.500'], ['J01.637.836.299'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['J01.637.512.600.500'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100'], ['J01.637.836']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
How much are we spending? The estimation of research expenditures on cardiovascular disease in Canada. | BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in Canada and is a priority area for medical research. The research funding landscape in Canada has changed quite a bit over the last few decades, as have funding levels. Our objective was to estimate the magnitude of expenditures on CVD research for ... | ['Academies and Institutes', 'Annual Reports as Topic', 'Biomedical Research', 'Canada', 'Cardiovascular Diseases', 'Cost of Illness', 'Fellowships and Scholarships', 'Health Expenditures', 'Humans', 'Organizations, Nonprofit', 'Public Sector', 'Research Support as Topic'] | 22,929,001 | [['N03.540.052'], ['N04.452.070'], ['H01.770.644.145'], ['Z01.107.567.176'], ['C14'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['N03.219.483.838.276'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.630'], ['I01.795', 'N04... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Exercise training and heart rate variability in older adult female subjects. | INTRODUCTION: Prior investigations in post-myocardial infarction and healthy elderly subjects have established that heart rate variability (HRV) predicts mortality. Predominantly cross-sectional studies have shown an association between endurance training and measures of HRV. In a randomized trial, this study sought to... | ['Aged', 'Body Mass Index', 'Exercise', 'Female', 'Heart Rate', 'Humans', 'Middle Aged', 'Monitoring, Physiologic', 'Oxygen Consumption', 'Physical Endurance', 'Physical Fitness'] | 16,553,360 | [['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['G03.680'], ['G11.427.680', 'I03.450... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. | OBJECTIVE: The surgical treatment of extensive diffuse pigmented villonodular synovitis (PVNS) of large joints alone is unsatisfactory, with high rates of local recurrence. Post-synovectomy adjuvant treatment with external beam radiation therapy or intra-articular injection of yttrium 90 (90Y) yielded better results. W... | ['Adolescent', 'Adult', 'Ankle Joint', 'Arthrography', 'Combined Modality Therapy', 'Female', 'Follow-Up Studies', 'Hip Joint', 'Humans', 'Injections, Intra-Articular', 'Knee Joint', 'Magnetic Resonance Imaging', 'Male', 'Radionuclide Imaging', 'Recurrence', 'Synovectomy', 'Synovial Membrane', 'Synovitis, Pigmented Vil... | 12,364,629 | [['M01.060.057'], ['M01.060.116'], ['A02.835.583.378.062'], ['E01.370.350.700.070'], ['E02.186'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.380'], ['A02.835.583.475'], ['E01.370.350.8... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pressure-geometry relationship in the antroduodenal region in humans. | Understanding of the control mechanisms underlying gastric motor function is still limited. The aim of the present study was to evaluate antral pressure-geometry relationships during gastric emptying slowed by intraduodenal nutrient infusion and enhanced by erythromycin. In seven healthy subjects, antral contractile ac... | ['Duodenum', 'Erythromycin', 'Fat Emulsions, Intravenous', 'Female', 'Gastric Emptying', 'Gastrointestinal Agents', 'Gastrointestinal Motility', 'Humans', 'Infusions, Parenteral', 'Injections, Intravenous', 'Magnetic Resonance Imaging', 'Male', 'Manometry', 'Motilin', 'Parenteral Nutrition', 'Pressure', 'Pyloric Antrum... | 11,668,030 | [['A03.556.124.684.124', 'A03.556.875.249'], ['D02.540.576.500.992'], ['D26.255.165.260.270', 'D26.776.708.733.500', 'D27.505.954.578.733.500', 'D27.720.752.733.500'], ['G10.261.360.400'], ['D27.505.954.483'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510'], ['E02.319.267.082.750',... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Missed opportunities for primary repair in complicated acute diverticulitis. | BACKGROUND: Complicated acute diverticulitis (CAD) requiring an urgent operation is usually managed by fecal diversion (FD) despite reports suggesting that primary repair (PR) is safe. We aim to identify patient characteristics predicting successful PR and explore if patients are managed by FD despite the presence of s... | ['Acute Disease', 'Adult', 'Aged', 'Diverticulitis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications'] | 20,378,139 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['C06.405.205.282.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Autophosphorylation of gatekeeper tyrosine by symbiosis receptor kinase. | Plant receptor-like kinases (RLKs) share their evolutionary origin with animal interleukin-1 receptor-associated kinase (IRAK)/Pelle family of soluble kinases and are distinguished by having tyrosine as 'gatekeeper'. This position is adjacent to the hinge region and is hidden in a hydrophobic pocket of the catalytic cl... | ['Amino Acid Motifs', 'Arachis', 'Catalytic Domain', 'Cell Line', 'Gene Expression Regulation, Plant', 'Mutation', 'Phosphorylation', 'Plant Proteins', 'Protein Binding', 'Receptor Protein-Tyrosine Kinases', 'Recombinant Proteins', 'Signal Transduction', 'Tyrosine'] | 23,962,520 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.650.940.800.575.912.250.401.077'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['A11.251.210'], ['G05.308.375'], ['G05.365.590'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D12.776.765'], ['G02.111.679', 'G03.808'], ['D08.811.913.6... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Binding of rho factor to Escherichia coli RNA polymerase mediated by nusA protein. | The E. coli transcription termination factor rho binds specifically to purified nusA protein. Since nusA protein binds tightly to RNA polymerase, this provides a way of coupling rho to the elongating RNA polymerase complex through protein-protein interactions. These rho-nusA interactions may play a role in modulating r... | ['Adenosine Triphosphatases', 'Bacterial Proteins', 'DNA-Directed RNA Polymerases', 'Escherichia coli', 'Kinetics', 'Protein Binding', 'Rho Factor', 'Transcription Factors'] | 6,096,352 | [['D08.811.277.040.025'], ['D12.776.097'], ['D08.811.913.696.445.735.270'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['G02.111.679', 'G03.808'], ['D12.776.930.785'], ['D12.776.930']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine. | We investigated the charge transfer interactions between luminescent quantum dots (QDs) and redox active dopamine. For this, we used pH-insensitive ZnS-overcoated CdSe QDs rendered water-compatible using poly (ethylene glycol)-appended dihydrolipoic acid (DHLA-PEG), where a fraction of the ligands was amine-terminated ... | ['Dopamine', 'Electrochemistry', 'Hydrogen-Ion Concentration', 'Luminescent Measurements', 'Optical Phenomena', 'Oxidation-Reduction', 'Oxygen', 'Polyethylene Glycols', 'Quantum Dots', 'Thioctic Acid'] | 22,394,283 | [['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['H01.181.529.307'], ['G02.300'], ['E05.196.712.516'], ['G01.590'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['E07.705', 'J01.637.512.6... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Childhood acute leukemia: a search for occult extramedullary disease prior to discontinuation of chemotherapy. | Between January 1978 and September 1979, 29 children with acute leukemia in complete continuous remission for three or more years were examined for evidence of occult extramedullary disease immediately prior to discontinuation of chemotherapy. Bilateral open wedge testicular biopsy demonstrated the presence of bilatera... | ['Adolescent', 'Adult', 'Antineoplastic Agents', 'Biopsy', 'Child', 'Child, Preschool', 'Electroencephalography', 'Female', 'Humans', 'Kidney', 'Leukemia, Lymphoid', 'Liver', 'Male', 'Neoplasm Metastasis', 'Testis', 'Tomography, X-Ray Computed', 'Ultrasonography', 'Urography'] | 6,945,902 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.248'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Task-based profile of vocal intensity decline in Parkinson's disease. | This study examines intensity decay in the phonation of persons with Parkinson's disease (PD). The decline in vocal intensity (determined by linear regression of the intensity envelope) was compared across the following tasks: vowel prolongation, syllable repetition (diadochokinesis, DDK), isolated sentences and conver... | ['Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Parkinson Disease', 'Phonation', 'Sound', 'Speech Acoustics', 'Speech Production Measurement', 'Vocal Cords', 'Voice Disorders'] | 15,655,339 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain. | We examined antinociception and gene expression of mu-opioid receptor 1 (MOR1) in some brain areas of cholestatic rats, 21 days after common bile duct ligation (BDL). Cholestasis was induced in male Wistar rats during laparotomy and common BDL. Pain behavior was assessed on days 7, 14 or 21 of BDL using a hotplate test... | ['Analysis of Variance', 'Animals', 'Bile Duct Diseases', 'Brain', 'Disease Models, Animal', 'Gene Expression Regulation', 'Laparotomy', 'Male', 'Naloxone', 'Narcotic Antagonists', 'Pain', 'Pain Measurement', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Receptors, Opioid, mu', 'Time Factors'] | 25,290,008 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['C06.130.120'], ['A08.186.211'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308'], ['E04.406'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['D27.505.696.543', 'D27.505.696.663.850.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sharing information with adults conceived as a result of donor insemination. | A growing number of jurisdictions have introduced legislation to give children the right to information about, and identity of, 'their' gamete donor. This has been accompanied by a reduction in the social stigma associated with infertility and building families with the assistance of donated gametes. This changing cult... | ['Adult', 'Female', 'Humans', 'Insemination, Artificial, Heterologous', 'Male', 'Parent-Child Relations', 'Tissue Donors', 'Truth Disclosure'] | 16,825,110 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.875.800.937.515', 'E05.820.800.937.515', 'G08.686.784.363.492.500'], ['F01.829.263.370.290'], ['M01.898'], ['F01.829.401.046.800', 'I01.880.604.583.080.134.800']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Bimodal regulation of secretion by cytoplasmic Ca2+ as demonstrated by the parathyroid. | Bovine parathyroid cells were used to study parathyroid hormone (PTH) release and the cytoplasmic Ca2+ concentration (Cai2+). When the extracellular Ca2+ concentration was decreased from 3.0 to 0.5 mM, perifused cells reacted with rapid stimulation of PTH release. However, a further reduction of extracellular Ca2+ to l... | ['Aminoquinolines', 'Animals', 'Calcium', 'Cattle', 'Cyclic AMP', 'Egtazic Acid', 'Homeostasis', 'Parathyroid Glands', 'Parathyroid Hormone', 'Phospholipids', 'Protein Kinases'] | 3,030,807 | [['D03.633.100.810.050'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.500.380.271'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['G07.410'], ['A06.300.560'], ['D06... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MRI of the lumbar spine at 7 Tesla in healthy volunteers and a patient with congenital malformations. | OBJECTIVE: The aim of this study was to evaluate sequences that are established at lower magnetic field strengths for lumbar spine imaging at 7 Tesla (7 T) MR imaging.MATERIALS AND METHODS: The lumbar spine of five healthy volunteers and a patient with spina bifida and meningocele were evaluated at 7 T. The examination... | ['Adult', 'Artifacts', 'Cerebrospinal Fluid', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Intervertebral Disc', 'Lumbar Vertebrae', 'Magnetic Fields', 'Magnetic Resonance Imaging', 'Male', 'Meningocele', 'Reference Values', 'Spinal Dysraphism'] | 21,604,210 | [['M01.060.116'], ['E05.047'], ['A12.207.270.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['A02.835.232.834.519'], ['G01.358.750'], ['E01.370.350.825.500'], ['C10.500.680.598', 'C16.131.666.680.598', 'C23.300.707.968'], ['E05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
One-stage or two-stage revision surgery for prosthetic hip joint infection--the INFORM trial: a study protocol for a randomised controlled trial. | BACKGROUND: Periprosthetic joint infection (PJI) affects approximately 1% of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, antibiotics and implant retention; revision THR; excision of the joint and amputat... | ['Arthroplasty, Replacement, Hip', 'Clinical Protocols', 'Cost-Benefit Analysis', 'Hip Joint', 'Humans', 'Infections', 'Joint Diseases', 'Outcome Assessment, Health Care', 'Postoperative Complications', 'Qualitative Research', 'Quality of Life'] | 26,883,420 | [['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E02.183', 'N05.715.360.330.125'], ['N03.219.151.125'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['C05.550'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['C23.550.767'], ['H01.770.644.241.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
[Several observations on delivery of Hippocatric treatises in Arabic and Greek tradition]. | It has been known for a long time that most of the published Arabic translations of the Hippocratic treatises are based on the Lemmata of Galen's commentaries (2nd c. AC). In this paper I will discuss some philological characteristics which support this view but have not yet been taken into account: 1. Phrases at the b... | ['Greece, Ancient', 'History, Ancient', 'Humans', 'Language', 'Manuscripts, Medical as Topic', 'Translating'] | 16,425,843 | [['Z01.586.035.519'], ['K01.400.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['L01.178.682.608.526'], ['L01.559.423.796']] | ['Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Myocardial revascularisation in patients with severe left ventricular dysfunction. Early and midterm results. | AIMS: This retrospective study evaluates early and midterm results in patients with severe left ventricular dysfunction.TECHNIQUE: Ninety-seven consecutive patients with coronary artery disease and ejection fraction of left ventricle (LVEF) less or equal to 25 % underwent elective coronary artery bypass graft procedure... | ['Aged', 'Aged, 80 and over', 'Coronary Artery Bypass', 'Coronary Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Survival Rate', 'Ventricular Dysfunction, Left'] | 15,523,547 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[A large pancreatic pseudocyst penetrating into mediastinum causing progressive airways occlusion and death: a case report]. | Pancreatic pseudocysts arise mostly as a complication of acute or chronic pancreatitis. In this paper we present a case of 44-years-old female suffering from large pancreatic pseudocyst leading to death, as a result of airways suppression. | ['Adult', 'Airway Obstruction', 'Fatal Outcome', 'Female', 'Humans', 'Laryngeal Edema', 'Mediastinal Cyst', 'Pancreatic Pseudocyst', 'Pancreatitis', 'Tomography, X-Ray Computed'] | 11,816,749 | [['M01.060.116'], ['C08.618.846.185'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.360.313', 'C09.400.313'], ['C04.182.444', 'C08.846.187.145'], ['C04.182.640.692', 'C06.689.500.692'], ['C06.689.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Application of the updated Framingham risk score to Japanese men. | Few tools for risk assessment of coronary heart disease (CHD) have yet been made available in Japan. This study aims to examine the validity of the updated Framingham risk score as applied to a Japanese male population. Using the annual health examination database of a Japanese company, we followed-up 5,611 male subjec... | ['Adult', 'Asian Continental Ancestry Group', 'Coronary Disease', 'Humans', 'Japan', 'Male', 'Middle Aged', 'ROC Curve', 'Risk Assessment'] | 11,768,728 | [['M01.060.116'], ['M01.686.508.200'], ['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['E05.318.740.600.800.715', 'N04.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Eznzymatic conversions of ortho-nitrophenyl organophosphorus compounds in the tissues of white rats]. | In homogenates of rat tissues hydrolysis of O-heptyl-O-orthonitrophenylmethyl phosphonate, O-pentyl-O-orthonitrophenylmethyl phosphonate and O-heptyl-O-isopentyl-O-orthonitrophenylphosphate was studied. Hydrolysis of the preparation was shown to be carried out mainly in liver tissue and slso in kidney and blood serum. ... | ['Animals', 'Brain', 'Enzymes', 'Hydrolysis', 'In Vitro Techniques', 'Intestine, Small', 'Kidney', 'Kinetics', 'Liver', 'Male', 'Nitrobenzenes', 'Organophosphorus Compounds', 'Rats', 'Structure-Activity Relationship'] | 1,030,887 | [['B01.050'], ['A08.186.211'], ['D08.811'], ['G02.380'], ['E05.481'], ['A03.556.124.684'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['D02.455.426.559.389.565', 'D02.640.529'], ['D02.705'], ['B01.050.150.900.649.313.992.635.505.700'], ['G02.111.830', 'G07.690.773.997']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Degenerative evolution and functional diversification of type-III secretion systems in the insect endosymbiont Sodalis glossinidius. | Sodalis glossinidius, a maternally transmitted endosymbiont of tsetse flies, maintains two phylogenetically distinct type-III secretion systems encoded by chromosomal symbiosis regions designated SSR-1 and SSR-2. Although both symbiosis regions are closely related to extant pathogenicity islands with similar gene inven... | ['Animals', 'Bacterial Proteins', 'Cell Line', 'Evolution, Molecular', 'Gram-Negative Bacteria', 'Insecta', 'Symbiosis'] | 15,574,807 | [['B01.050'], ['D12.776.097'], ['A11.251.210'], ['G05.045.250', 'G16.075.250'], ['B03.440'], ['B01.050.500.131.617'], ['G06.550.800', 'G16.840']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter. | Programmed death-1 ligand 2 (PD-L2) expression extends beyond macrophages/dendritic cells to B-1 B cells, a distinct B-cell lineage that is responsible for natural immunoglobulin and which is repertoire skewed toward autoreactive specificities. PD-L2 expression is constitutive in B-1 cells, whereas it is inducible in o... | ['Animals', 'B-Lymphocytes', 'Cell Line, Tumor', 'Gene Expression Regulation', 'Macrophages, Peritoneal', 'Mice', 'Mice, Inbred BALB C', 'Octamer Transcription Factor-1', 'Octamer Transcription Factor-2', 'Organ Specificity', 'Peptides', 'Programmed Cell Death 1 Ligand 2 Protein', 'Promoter Regions, Genetic', 'Transcri... | 19,710,692 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.308'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630', 'A15.382.680.397.630'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of acetylcholine on inositol 1,4,5-triphosphate formation in cervix uteri myometrial cells of human]. | AIM: To detect inositol 1,4,5-triphosphate (IP3) formation of pregnant and nonpregnant human myometrial cells induced by acetylcholine (ACh).METHODS: [3H] IP3 competitive protein binding assay.RESULTS: Basal levels of IP3 in pregnant and nonpregnant human myometrial cells were (82 +/- 9) and (96 +/- 10) nmol.g-1 (prote... | ['Acetylcholine', 'Adult', 'Atropine', 'Cell Separation', 'Female', 'Humans', 'Inositol 1,4,5-Trisphosphate', 'Muscarinic Antagonists', 'Myometrium', 'Oxytocin', 'Pregnancy', 'Vasodilator Agents'] | 10,678,135 | [['D02.092.211.111'], ['M01.060.116'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.800.519.400.350', 'D09.853... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Detection of antibodies after immune complex splitting in serum of patients with bullous pemphigoid and systemic lupus erythematosus. | No free anti-basement membrane antibodies were found in the sera of four patients with bullous pemphigoid, and no free anti-DNA antibodies in the sera of two patients with systemic lupus erythematosus. The sera treated with 3 mol/l urea and by gel chromatography to separate these antibodies from any circulating complex... | ['Antibodies', 'Antigen-Antibody Complex', 'Basement Membrane', 'DNA', 'Electrophoresis, Disc', 'Fluorescent Antibody Technique', 'Humans', 'Immunodiffusion', 'Immunoelectrophoresis', 'Lupus Erythematosus, Systemic', 'Skin Diseases, Vesiculobullous'] | 104,725 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['A10.272.220', 'A10.615.179'], ['D13.444.308'], ['E05.196.401.402.236', 'E05.301.300.319.403'], ['E01.370.225.500.607.512.240... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
APOE epsilon4 is a high-risk factor for Alzheimer's disease in the Mongolian population. | To determine the relationship between apolipoprotein E (APOE) epsilon4 and sporadic Alzheimer's disease (SAD) in the Mongolian population in China, we examined 106 Mongolian SAD patients in China and 100 Mongolian healthy controls. All subjects were genotyped for APOE. The odds ratio (OR) for developing SAD was signifi... | ['Aged', 'Aged, 80 and over', 'Alleles', 'Alzheimer Disease', 'Apolipoproteins E', 'DNA', 'Female', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Mongolia', 'Phenotype', 'Psychiatric Status Rating Scales', 'Reverse Transcriptase Polymerase Chain Reaction', 'Risk Factors'] | 19,819,468 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['D13.444.308'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.252.474.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Presenilin dependence of phospholipase C and protein kinase C signaling. | Presenilins (PSs) are involved in processing several proteins such as the amyloid precursor protein (APP), as well as in pathways for cell death and survival. We previously showed that some familial Alzheimer's disease PS mutations cause increased basal and acetylcholine muscarinic receptor-stimulated phospholipase C (... | ['Alzheimer Disease', 'Amyloid beta-Protein Precursor', 'Animals', 'Brain', 'Cells, Cultured', 'Down-Regulation', 'Fibroblasts', 'Gene Expression Regulation, Enzymologic', 'Isoenzymes', 'Mice', 'Mice, Knockout', 'Presenilin-1', 'Presenilin-2', 'Presenilins', 'Protein Kinase C', 'Protein Kinase C-alpha', 'Protein Kinase... | 17,437,536 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['B01.050'], ['A08.186.211'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.329.228'], ['G05.308.320'], ['D08.811.348', 'D12.776.800.300'], ['B01.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men. | OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 ... | ['Adipose Tissue', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'Cohort Studies', 'Diabetes Mellitus, Type 2', 'Follow-Up Studies', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Prospective Studies', 'United Kingdom'] | 20,413,526 | [['A10.165.114'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C18.452.394.750.149', 'C19... | ['Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. | Caveolin-3, a muscle-specific caveolin-related protein, is the principal structural protein of caveolae membrane domains in striated muscle cells. Recently, we identified a novel autosomal dominant form of limb-girdle muscular dystrophy (LGMD-1C) in humans that is due to mutations within the coding sequence of the huma... | ['Animals', 'Calcium Channels, L-Type', 'Caveolin 3', 'Caveolins', 'Dystrophin', 'Glycoproteins', 'Humans', 'Membrane Microdomains', 'Mice', 'Mice, Knockout', 'Microtubules', 'Muscle Proteins', 'Muscle, Skeletal', 'Muscular Dystrophies', 'Muscular Dystrophy, Animal', 'Mutation', 'Restriction Mapping', 'Ryanodine Recept... | 11,259,414 | [['B01.050'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['D12.776.210.500.235', 'D12.776.543.990.100.875'], ['D12.776.543.990.100'], ['D12.776.210.500.250', 'D12.776.220.250', 'D12.776.543.250'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An evaluation of a new test of reactive agility and its relationship to sprint speed and change of direction speed. | The purpose of this study was to evaluate the reliability and validity of a new test of agility, the reactive agility test (RAT), which included anticipation and decision-making components in response to the movements of a tester. Thirty-eight Australian football players took part in the study, categorized into either ... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Decision Making', 'Football', 'Humans', 'Male', 'Motor Skills', 'Movement', 'Observer Variation', 'Reproducibility of Results', 'Research Design'] | 16,844,413 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.785.373'], ['I03.450.642.845.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808.260'], ['G07.568', 'G11.427.410'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Curvelet Transform-based volume fusion for correcting signal loss artifacts in Time-of-Flight Magnetic Resonance Angiography data. | Flow fields in cerebral aneurysms can be measured in vivo with phase-contrast MRI (4D Flow MRI), providing 3D anatomical magnitude images as well as 3-directional velocities through the cardiac cycle. The low spatial resolution of the 4D Flow MRI data, however, requires the images to be co-registered with higher resolu... | ['Artifacts', 'Cerebral Angiography', 'Cerebrovascular Circulation', 'Humans', 'Imaging, Three-Dimensional', 'Intracranial Aneurysm', 'Magnetic Resonance Angiography', 'Sensitivity and Specificity'] | 29,929,053 | [['E05.047'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['G09.330.100.159'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['C10.228.140.300.510.600', 'C14.907.055.635... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Relationship of muscular fatigue to pH and diprotonated Pi in humans: a 31P-NMR study. | Seventeen normal subjects performed maximal wrist flexion exercise with continuous monitoring of forearm muscle pH and H2PO4-, measured with 31P nuclear magnetic resonance, and muscle fatigue, expressed as a percentage of decline in maximal developed force. Four minutes of exercise (flexion duration = 1 s) reduced maxi... | ['Adult', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Male', 'Muscle Contraction', 'Muscles', 'Phosphates', 'Phosphorus', 'Physical Exertion'] | 3,403,417 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['G11.427.494'], ['A02.633', 'A10.690'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['D01.268.666'], ['G11.427.683']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
When minutes count--the fallacy of accurate time documentation during in-hospital resuscitation. | UNLABELLED: The purpose of this study is to examine the commonly held assumption that time is measured and documented accurately during resuscitation from cardiac arrest in the hospital.METHODS: A two-pronged approach was used to evaluate the accuracy of time documentation and measurement. First, two existing databases... | ['Documentation', 'Hospitalization', 'Humans', 'Resuscitation', 'Time Factors'] | 15,919,564 | [['L01.453.245'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.365.647'], ['G01.910.857']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Eukoenenia ibitipoca: the first troglobitic Palpigradi (Arachnida) from a quartzitic cave. | Although the arachnids of the order Palpigradi are very common in subterranean habitats, no species has yet been recorded from siliciclastic caves. During a survey of cave invertebrates conducted in quartizitic caves in southern Minas Gerais state (Brazil), the occurrence of a new troglobitic palpigrade was revealed. A... | ['Animals', 'Arachnida', 'Brazil', 'Ecosystem', 'Invertebrates'] | 31,716,809 | [['B01.050'], ['B01.050.500.131.166'], ['Z01.107.757.176'], ['G16.500.275.157', 'N06.230.124'], ['B01.050.500']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
MMGBSA as a tool to understand the binding affinities of filamin-peptide interactions. | Filamins (FLN) are large dimeric proteins that cross-link actin and work as important scaffolds in human cells. FLNs consist of an N-terminal actin-binding domain followed by 24 immunoglobulin-like domains (FLN1-24). FLN domains are divided into four subgroups based on their amino acid sequences. One of these subgroups... | ['Algorithms', 'Binding Sites', 'CD18 Antigens', 'Cell Adhesion Molecules', 'Cytoskeletal Proteins', 'Filamins', 'Humans', 'Integrin beta Chains', 'Ligands', 'Molecular Dynamics Simulation', 'Peptides', 'Platelet Glycoprotein GPIb-IX Complex', 'Protein Binding', 'Protein Interaction Domains and Motifs', 'Protein Intera... | 23,988,151 | [['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['D12.776.395.550.200.275.750', 'D12.776.543.550.200.275.750', 'D12.776.543.750.705.408.200.249', 'D12.776.543.750.705.408.600.100.750', 'D12.776.543.750.705.833.249.750', 'D23.050.301.264.894.118', 'D23.050.301.350.275.750', 'D23.101.100.894.118'], ['D12.776.395.550.20... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats. | Background The negative impact of diabetes on the liver is well documented. The white butterfly (Clerodendrum volubile) leaf has been used in traditional practices for the treatment of various diseases, such as hypertension, diabetes, and rheumatism, but without scientific validation. This work was designed to evaluate... | ['Animals', 'Clerodendrum', 'Diabetes Mellitus, Experimental', 'Liver Diseases', 'Male', 'Oxidative Stress', 'Plant Extracts', 'Plant Leaves', 'Rats', 'Rats, Wistar'] | 30,133,418 | [['B01.050'], ['B01.650.940.800.575.912.250.583.520.121'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C06.552'], ['G03.673', 'G07.775.750'], ['D20.215.784.500', 'D26.667'], ['A18.024.812'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Feasibility of frequent patient-reported outcome surveillance in patients undergoing hematopoietic cell transplantation. | Patient-reported outcomes (PROs), including symptoms and health-related quality of life (HRQOL), provide a patient-centered description of hematopoietic cell transplantation (HCT)-related toxicity. These data characterize the patient experience after HCT and may have prognostic usefulness for long-term outcomes after H... | ['Aged', 'Electronic Health Records', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Leukemia', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Myeloablative Agonists', 'Quality of Life', 'Self Report', 'Severity of Illness Index', 'Transplantation Conditioning', 'Transplantation, Autologous', 'Transplanta... | 23,253,558 | [['M01.060.116.100'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Clinical, electrophysiological and pathological findings of a patient with CMT2 due to the p.Ala738Val mitofusin 2 mutation. | Mutations in the gene encoding mitofusin 2 (MFN2) are responsible of about 20% of Charcot-Marie-Tooth disease type 2 (CMT2) case. A great variability exists among CMT2A concerning severity and associated clinical features. Generally patients with an early onset CMT2A disclose a severe phenotype while the cases with a l... | ['Adult', 'Alanine', 'Charcot-Marie-Tooth Disease', 'Electrodiagnosis', 'Female', 'GTP Phosphohydrolases', 'Humans', 'Mitochondrial Proteins', 'Neural Conduction', 'Point Mutation', 'Sural Nerve', 'Valine'] | 21,601,224 | [['M01.060.116'], ['D12.125.042'], ['C10.500.300.200', 'C10.574.500.495.200', 'C10.668.829.800.300.200', 'C16.131.666.300.200', 'C16.320.400.375.200'], ['E01.370.405'], ['D08.811.277.040.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.575'], ['G07.265.753', 'G11.561.601'], ['G05.365.590.675'], ['A08.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of three methods for determining CT dose profile: presenting the tritium method. | The purpose of the present work was to describe a method of using an imaging plate from a computed radiography system to determine the computed tomography (CT) dose profile (the tritium method) and to compare this method with point-dose measurements using a solid-state detector (CT Dose Profiler; RTI Electronics, M?lnd... | ['Body Burden', 'Radiation Dosage', 'Radiometry', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Tomography, X-Ray Computed', 'Tritium', 'X-Ray Intensifying Screens'] | 20,200,099 | [['E05.799.638.231', 'N06.850.460.200'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.799'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Demonstration of two different vitamin D-dependent calcium-binding proteins in rat intestinal mucosa. | The characteristics and location of rat intestinal proteins with calcium binding properties were reexamined using both a 45Ca-equilibrated Sephadex G-100 column and the chelex 100 method in the assay of 45Ca binding activity. The rat intestinal mucosa was found to have three different proteins with calcium binding prop... | ['Animals', 'Calcium', 'Female', 'Intestinal Mucosa', 'Molecular Weight', 'Protein Binding', 'Proteins', 'Rats', 'Vitamin D', 'Vitamin D Deficiency'] | 1,214,178 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A03.556.124.369', 'A10.615.550.444'], ['G02.494'], ['G02.111.679', 'G03.808'], ['D12.776'], ['B01.050.150.900.649.313.992.635.505.700'], ['D04.210.500.812.768'], ['C18.654.521.500.133.770']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3D-QSAR study on a series of Bcl-2 protein inhibitors using comparative molecular field analysis. | In this manuscript, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies using comparative molecule field analysis (CoMFA) techniques were applied to provide the structural information of Bcl-2 inhibitors. The CoMFA model obtained from the training set were all statistically significant with... | ['Biphenyl Compounds', 'Enzyme Inhibitors', 'Models, Molecular', 'Molecular Conformation', 'Nitrophenols', 'Piperazines', 'Protein Binding', 'Proto-Oncogene Proteins c-bcl-2', 'Quantitative Structure-Activity Relationship', 'Reproducibility of Results', 'Static Electricity', 'Statistics as Topic', 'Sulfonamides'] | 21,171,944 | [['D02.455.426.559.389.185'], ['D27.505.519.389'], ['E05.599.595'], ['G02.111.570.820'], ['D02.455.426.559.389.657.566', 'D02.640.743'], ['D03.383.606'], ['G02.111.679', 'G03.808'], ['D12.644.360.075.718', 'D12.776.476.075.718', 'D12.776.624.664.700.169'], ['G02.111.830.500', 'G07.690.773.997.500'], ['E05.318.370.725',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
An assay for human erythrocyte catechol-O-methyltransferase activity using a catechol estrogen as the substrate. | A radiometric assay for catechol-O-methyltransferase (COMT) activity in human erythrocytes is described that employs 2-hydroxy[3H]estrone, and non-radiolabeled S-adenosylmethionine (SAM) as the cosubstrates. The ease of separation of the product of the reaction, 2-methoxy[3H]estrone from 2-hydroxy[3H]estrone makes it p... | ['Carbon Radioisotopes', 'Catechol O-Methyltransferase', 'Erythrocytes', 'Humans', 'Hydroxyestrones', 'Isotope Labeling', 'Kinetics', 'Magnesium', 'S-Adenosylmethionine', 'Tritium'] | 455,720 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrostatic control of the rate-determining step of the copper, zinc superoxide dismutase catalytic reaction. | The dependence of the activity of bovine Cu,Zn superoxide dismutase on pH and ionic strength was extensively investigated in the ranges of pH 7.4-pH 12.3 and of ionic strength of 0.02-0.25 M. The results obtained indicate that two positively charged groups having pK values of approximately 10.1 and 10.8 are involved in... | ['Animals', 'Cattle', 'Electrochemistry', 'Erythrocytes', 'Hydrogen-Ion Concentration', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Osmolar Concentration', 'Superoxide Dismutase'] | 3,607,020 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['H01.181.529.307'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['G02.640'], ['D08.811.682.881']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition. | Na+/H+ exchanger-1 (NHE-1) inhibition induces cardiac hypertrophy regression and (or) prevention in several experimental models, although the intracellular events involved remain unclarified. We aimed to determine whether the calcineurin/NFAT pathway mediates this effect of NHE-1 inhibitors. Spontaneously hypertensive ... | ['Animals', 'Animals, Newborn', 'Anti-Arrhythmia Agents', 'Calcineurin', 'Calcium', 'Cardiomegaly', 'Cells, Cultured', 'Guanidines', 'Hypertension', 'Male', 'Myocardium', 'Myocytes, Cardiac', 'NFATC Transcription Factors', 'Natriuretic Peptide, Brain', 'RNA, Messenger', 'Rats', 'Rats, Inbred SHR', 'Rats, Wistar', 'Sodi... | 17,612,638 | [['B01.050'], ['B01.050.050.282'], ['D27.505.954.411.097'], ['D08.811.277.352.650.625.150', 'D12.644.360.087', 'D12.776.476.087'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C14.280.195', 'C23.300.775.250'], ['A11.251'], ['D02.078.370'], ['C14.907.489'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Disease-avoidant behaviour and its consequences. | Medical conditions that are non-contagious, but that appear contagious, seem to result in the sufferer being avoided. Error management theory (EMT), suggests that such false alarms occur because the cost of infection poses a greater threat to ones fitness than avoidance. Study 1 attempted to demonstrate a disease-relat... | ['Avoidance Learning', 'Communicable Diseases', 'Culture', 'Emotions', 'Facial Dermatoses', 'Female', 'Humans', 'Illness Behavior', 'Interpersonal Relations', 'Judgment', 'Male', 'Social Desirability', 'Social Stigma', 'Young Adult'] | 21,801,076 | [['F02.463.425.097', 'F02.463.785.373.173'], ['C01.221', 'C23.550.291.531'], ['I01.076.201.450', 'I01.880.853.100'], ['F01.470'], ['C17.800.271'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.499'], ['F01.829.401'], ['F02.463.785.626'], ['F01.145.813.628'], ['F01.145.813.840'], ['M01.060.116.815']] | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Preoperative chemotherapy for prostatic stromal invasive urothelial bladder cancer: comparison of oncological outcomes of male patients with cT4a disease undergoing radical cystectomy with or without preoperative chemotherapy. | Background: The value of preoperative chemotherapy to prostatic stromal invasive urothelial bladder cancer remains uncertain. This study presented the pathological response and oncological outcomes of male patients with cT4a urothelial bladder cancer managed with preoperative chemotherapy followed by radical cystectomy... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Transitional Cell', 'Case-Control Studies', 'Cisplatin', 'Cystectomy', 'Deoxycytidine', 'Disease-Free Survival', 'Doxorubicin', 'Humans', 'Induction Chemotherapy', 'Kaplan-Meier Estimate', 'Lymph Node Excision', 'Lymph Nodes', 'Male', 'Methotrexate'... | 31,081,431 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.430'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E04.950.774.150'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging. | We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with ... | ['Animals', 'Cattle', 'Coated Materials, Biocompatible', 'Contrast Media', 'Dextrans', 'Dopamine', 'Drug Stability', 'HeLa Cells', 'Humans', 'Ions', 'Magnetic Resonance Imaging', 'Magnetite Nanoparticles', 'Male', 'Metabolic Clearance Rate', 'Mice', 'Molecular Conformation', 'Molecular Imaging', 'Tissue Distribution'] | 23,042,209 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D25.130.420', 'J01.637.051.130.420'], ['D27.505.259.500', 'D27.720.259'], ['D05.750.078.562.272', 'D09.698.365.272'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E05.916.330'], ['A11.251.210.190.400', 'A11.251.860.180.400'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
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