Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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[Occupational asthma: current and future perspectives. The point of view of an expert]. | Occupational asthma remains a difficult problem for physicians and for experts. The prevalence of occupational asthma is underestimated and depends on industrial agent and conditions of work. Diagnosis is made based on detailed description of the patient's work environment, on skin and serological tests, and on lung fu... | ['Asthma', 'Humans', 'Incidence', 'Occupational Diseases', 'Prevalence', 'Prognosis'] | 1,756,395 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C24'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.5... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The permeability of fish gills with comments on the osmotic behaviour of cellular membranes. | The permeability of eel gills to ions, lipid-soluble and -insoluble substances has been measured under steady-state conditions. The results obtained support the multi-pathway model for transcapillary transport (Stray-Pedersen and Steen 1975). The gills are 25 times more permeable to THO than to Na+ or K+. Metabolic inh... | ['Animals', 'Antipyrine', 'Benzocaine', 'Cell Membrane', 'Chlorides', 'Cyanides', 'Depression, Chemical', 'Dextrans', 'Drug Interactions', 'Edetic Acid', 'Eels', 'Ethanol', 'Gills', 'Osmosis', 'Ouabain', 'Potassium', 'Sodium', 'Stimulation, Chemical', 'Sucrose', 'Temperature', 'Urea', 'Water', 'Water-Electrolyte Balanc... | 809,998 | [['B01.050'], ['D03.383.129.539.850.088'], ['D02.241.223.100.050.500.643', 'D02.455.426.559.389.127.020.937.687'], ['A11.284.149'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D01.248.497.158.291', 'D01.625.400.100'], ['G07.690.773.750'], ['D05.750.078.562.272', 'D09.698.365.272'], ['G07.690.773.968'], ['D02.092.782.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Automated sperm concentration analysis with a new flow cytometry-based device, S-FCM. | The S-FCM uses flow cytometry technology to measure sperm concentrations. Semen samples from 104 men attending a male infertility clinic were used to evaluate the reproducibility of results and the carryover rate with the S-FCM by performing between- and within-run imprecision analyses. In addition, sperm concentration... | ['Autoanalysis', 'Flow Cytometry', 'Humans', 'Infertility, Male', 'Male', 'Quality Control', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sperm Count'] | 11,888,079 | [['E05.059'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['J01.897.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Genetic heterogeneity in multiple epiphyseal dysplasia. | Multiple epiphyseal dysplasia (MED) comprises a group of hereditary chondrodysplasias in which there are major anatomic abnormalities of the long tubular bones. The Fairbank and Ribbing types are the most frequently cited types of MED. They are primarily defined radiographically and are autosomal dominant conditions. R... | ['Adult', 'Child', 'Child, Preschool', 'Chromosomes, Human, Pair 19', 'Female', 'Genetic Heterogeneity', 'Genetic Linkage', 'Haplotypes', 'Humans', 'Male', 'Osteochondrodysplasias', 'Pedigree'] | 7,887,425 | [['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['A11.284.187.520.300.460.465', 'G05.360.162.520.300.460.465'], ['G05.365.331'], ['G05.348'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.099.708', 'C16.320.728'], ['E05.393.673']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Senile systemic amyloidosis: definition, diagnosis, why thinking about?]. | Senile systemic amyloidosis (SSA) is characterized by infiltration of amyloid transthyretin fibrils in the myocardium. SSA occurs mainly (but not always) in elderly men. SSA leads to hypertrophic and/or restrictive cardiomyopathy complicated by conduction disturbances, atrial arrhythmia and systemic embolization (strok... | ['Age Factors', 'Aged', 'Amyloidosis', 'Decision Trees', 'Heart Diseases', 'Humans'] | 23,669,316 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C18.452.845.500'], ['G17.162.500'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The gene for the atrial natriuretic factor is expressed in the aortic arch. | The gene for atrial natriuretic factor is expressed within the adventitial cells of the rat aortic arch. Atrial natriuretic factor transcripts, similar in overall size (1100-1200 nucleotides) and 5'-termini to those found in the atria, were identified in the arch. Much lower levels (approximately 10-20%) of these trans... | ['Animals', 'Aorta, Thoracic', 'Atrial Natriuretic Factor', 'Gene Expression Regulation', 'Genes', 'Pressoreceptors', 'RNA, Messenger', 'Rats', 'Rats, Inbred Strains'] | 2,947,852 | [['B01.050'], ['A07.015.114.056.372'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['G05.308'], ['G05.360.340.024.340'], ['A08.675.650.915.750.750', 'A08.800.050.800.900.700', 'A08.800.950.750.750', 'A11.671.650.915.750.750'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.7... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Family-centred care within contemporary British paediatric nursing. | The concept of family-centred care is such a cherished tenet of paediatric nursing to be almost above critique. Yet a close examination of the place and meaning-in-practice of family-centred care is long overdue if the term is not to lapse into mere clich? or slogan. | ['Family', 'Humans', 'Patient-Centered Care', 'Pediatric Nursing', 'United Kingdom'] | 7,881,250 | [['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.727.407'], ['H02.478.676.631', 'N02.421.533.691'], ['Z01.542.363']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Papillon-Lef?vre syndrome: neutrophil function in 15 cases fron 4 families in Egypt. | OBJECTIVE: The primary purpose of this study was to investigate the periodontal pathologic cause of Papillon-Lef?vre syndrome by comparing, with respect to neutrophil function, probands with Papillon-Lef?vre syndrome from 4 families in Egypt, unaffected siblings of the probands, and age-matched and gender-matched contr... | ['Adolescent', 'Adult', 'Blood Bactericidal Activity', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Consanguinity', 'Female', 'Humans', 'Infant', 'Male', 'Neutrophils', 'Opsonin Proteins', 'Papillon-Lefevre Disease', 'Pedigree', 'Phagocytosis'] | 10,503,862 | [['M01.060.057'], ['M01.060.116'], ['G09.188.100', 'G12.450.564.204'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['G05.090.403.180', 'G05.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A11.118.637.415.583', 'A11.627.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Depression and immunity: clinical factors and therapeutic course. | While many reports describe associations between depressive disorders and altered immunity, findings have not been fully consistent. Diagnostic subtype, demographic factors such as age and gender, medical characteristics, and the immune measures selected for assessment may have contributed to the heterogeneous findings... | ['Adolescent', 'Adult', 'Antidepressive Agents, Tricyclic', 'Antigens, CD', 'Depressive Disorder', 'Female', 'Humans', 'Killer Cells, Natural', 'Longitudinal Studies', 'Male', 'Severity of Illness Index'] | 10,195,317 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.700.122.055'], ['D23.050.301.264.035', 'D23.101.100.110'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.537', 'A15.382.490.555.567.537'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.50... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Robotic, Laparoscopic, or Open Hysterectomy: Surgical Outcomes by Approach in Endometrial Cancer. | STUDY OBJECTIVES: To compare patient outcomes by surgical approach in the management of endometrial cancer (EC) in Washington State from 2008 to 2013.DESIGN: Population-based retrospective cohort study (Canadian Task Force classification II-2).SETTING: Washington State.PATIENTS: EC patients treated with robotic-assiste... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Endometrial Neoplasms', 'Female', 'Hemorrhage', 'Humans', 'Hysterectomy', 'Laparoscopy', 'Length of Stay', 'Medical Records', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Patient Readmission', 'Postoperative Complications', 'Retrospective Studies', ... | 29,360,514 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E01.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. | AIM: Levels of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) are robustly increased in spinal muscular atrophy (SMA) patient fibroblasts and mouse models. We therefore wanted to establish whether changes in UCHL1 contribute directly to disease pathogenesis, and to assess whether pharmacological inhibition of UCHL1 r... | ['Animals', 'Cells, Cultured', 'Disease Models, Animal', 'Fibroblasts', 'Homeostasis', 'Humans', 'Indoles', 'Mice', 'Motor Activity', 'Motor Neurons', 'Muscular Atrophy, Spinal', 'Oximes', 'Survival of Motor Neuron 1 Protein', 'Ubiquitin Thiolesterase'] | 25,041,530 | [['B01.050'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.329.228'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['B01.050.150.900.649.313.992.635.505.500'], ['F01.145.632', 'G11.427.410.698'], ['A08.675.655.500', 'A11.671.655.500'], ['C10.228.854.468', 'C10.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vectorelectrocardiography in coronary artery disease. | Continuous ST-segment monitoring by either continuous 12-lead ECG or continuous vectorcardiography provides reliable information regarding ST changes in patients with ongoing myocardial ischemia with or without concurrent chest pain. ST-segment monitoring enables the clinician to continuously follow the dynamic changes... | ['Coronary Disease', 'Humans', 'Monitoring, Physiologic', 'Risk Assessment', 'Vectorcardiography'] | 11,405,499 | [['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['E01.370.370.380.240.850', 'E01.370.405.240.850']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Tailored liquid chromatography-mass spectrometry analysis improves the coverage of the intracellular metabolome of HepaRG cells. | Metabolomics protocols are often combined with Liquid Chromatography-Mass Spectrometry (LC-MS) using mostly reversed phase chromatography coupled to accurate mass spectrometry, e.g. quadrupole time-of-flight (QTOF) mass spectrometers to measure as many metabolites as possible. In this study, we optimised the LC-MS sepa... | ['Cell Line, Tumor', 'Chromatography, Liquid', 'Chromatography, Reverse-Phase', 'Humans', 'Mass Spectrometry', 'Metabolome', 'Metabolomics'] | 28,153,450 | [['A11.251.210.190', 'A11.251.860.180'], ['E05.196.181.400'], ['E05.196.181.400.495'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['G03.500'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Inappropriateness of cataract extraction: an analysis in two Israeli hospital settings. | OBJECTIVE: To assess and compare the appropriateness of cataract extraction in two Israeli regional hospitals.SETTINGS: Two Israeli hospitals located in different geographic areas.DESIGN: A randomized sample of 150 patients was drawn from a list of all patients who underwent cataract surgery at the two study hospitals ... | ['Cataract Extraction', 'Computer Security', 'Female', 'Humans', 'Israel', 'Male', 'Middle Aged', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Random Allocation', 'Surgery Department, Hospital', 'Unnecessary Procedures', 'User-Computer Interface', 'Visual Acuity'] | 10,351,589 | [['E04.540.825.249'], ['L01.224.134', 'N04.452.910.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['M01.060.116.630'], ['N04.761.700.350.650', 'N05.700.350.650'], ['N04.590.374.577', 'N05.300.625'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Profile of eicosanoid generation in aspirin-intolerant asthma and anaphylaxis assessed by new biomarkers. | BACKGROUND: It has recently demonstrated that a free radical-mediated pathway generates prostaglandins (PGs) and the corresponding prostaglandin enantiomers (ent-PGs). Aspirin-intolerant asthma and anaphylaxis accompany PGD(2) overproduction, possibly associated with mast cell activation via the COX pathway. However, f... | ['Adult', 'Aged', 'Anaphylaxis', 'Aspirin', 'Asthma', 'Biomarkers', 'Bleeding Time', 'Cysteine', 'Dinoprost', 'Eicosanoids', 'Female', 'Humans', 'Leukotrienes', 'Male', 'Middle Aged', 'Young Adult'] | 20,304,469 | [['M01.060.116'], ['M01.060.116.100'], ['C20.543.480.099'], ['D02.455.426.559.389.657.410.595.176'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D23.101'], ['E01.370.225.625.625.100', 'E05.200.625.625.100', 'G09.188.087'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.12... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
GetReal: from efficacy in clinical trials to relative effectiveness in the real world. | The GetReal consortium ("incorporating real-life data into drug development") addresses the efficacy-effectiveness gap that opens between the data from well-controlled randomized trials in selected patient groups submitted to regulators and the real-world evidence on effectiveness and safety of drugs required by decisi... | ['Clinical Trials as Topic', 'Drug Therapy', 'Humans', 'Meta-Analysis as Topic', 'Models, Theoretical', 'Patient Safety', 'Randomized Controlled Trials as Topic', 'Reproducibility of Results', 'Research Design', 'Review Literature as Topic'] | 27,390,256 | [['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E02.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['E05.599'], ['N06.850.135.060.075.399'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Prospective, randomized trial comparing four biofeedback techniques for patients with constipation. | PURPOSE: The aim of this study was to compare four methods of biofeedback for patients with constipation.METHODS: Thirty-six patients were prospectively, randomly assigned to one of four protocols: 1) outpatient intra-anal electromyographic biofeedback training; 2) electromyographic biofeedback training plus intrarecta... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biofeedback, Psychology', 'Catheterization', 'Child', 'Child, Preschool', 'Chronic Disease', 'Constipation', 'Electromyography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Muscle Contraction', 'Muscle, Smooth', 'Outpatients', 'Pelvic Floor', 'Peristalsis', 'Physica... | 10,566,525 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.190.525.123', 'F02.830.131', 'F04.754.137.301', 'F04.754.308.500'], ['E02.148', 'E05.157'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['C23.888.821.150'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predictors of medium and long-term outcome following capsulotomy for obsessive-compulsive disorder: one site may not fit all. | Patients with treatment-refractory obsessive-compulsive disorder (OCD) are sometimes considered for surgical interventions. The identification of reliable predictors of outcome following such interventions would be of great clinical importance, as it would lead to stricter selection of suitable patients, thus avoiding ... | ['Adult', 'Aged', 'Female', 'Follow-Up Studies', 'Humans', 'Internal Capsule', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neurosurgery', 'Obsessive-Compulsive Disorder', 'Outcome Assessment, Health Care', 'Predictive Value of Tests', 'Psychiatric Status Rating Scales', 'Regression Analysis', 'Time Factors'] | 22,209,362 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.200.885.385', 'A08.612.435'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['H02.403.810.425'], ['F03.080.600'], ['H01.770.644... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia. | The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One of the potential downstream targets of Akt1 is p70 S6 kinase, p70(S6K), an enzyme implicated in the regulation of protein synthesis. In this study, we investigated the changes in total and phosphorylated levels of Akt1 and p70(... | ['Animals', 'Arabidopsis Proteins', 'Blotting, Western', 'Cytosol', 'Ischemic Attack, Transient', 'Male', 'Middle Cerebral Artery', 'Phosphorylation', 'Plant Proteins', 'Potassium Channels', 'Rats', 'Rats, Wistar', 'Ribosomal Protein S6 Kinases'] | 11,162,248 | [['B01.050'], ['D12.776.765.149'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['A07.015.114.228.550'], ['G02.111.665', 'G02.607.780', 'G03.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Probenecid disposition by parallel Michaelis-Menten and dose-dependent pseudo-first-order processes. | Re-evaluation of published data on the urinary excretion of probenecid [4-(dipropylamino)sulfonylbenzoic acid, 1] and its metabolites as a function of orally administered dose has revealed that the elimination process is comprised of five parallel pathways. Excretion of the major metabolite, the acyl glucuronide 2 (35-... | ['Dose-Response Relationship, Drug', 'Glucuronates', 'Half-Life', 'Humans', 'Kinetics', 'Models, Biological', 'Oxidation-Reduction', 'Probenecid'] | 3,761,166 | [['G07.690.773.875', 'G07.690.936.500'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['G02.700', 'G03.295.531'], ['D02.065.884.625', 'D02.886.590.700.6... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioassays of APONIN-3 and -4 with rabbit erythrocytes. | Rabbit erythrocytes in methanolic phosphate medium were used to bioassay the activity of authentic samples of methyl stearate and methyl palmitate (in 10% methanol:90% water, v/v), which had been identified as apparent oceanic naturally occurring cytolins (APONIN-3 and -4) produced by Nannochloris oculata. The two natu... | ['Animals', 'Biological Assay', 'Chlorophyta', 'Cyclic N-Oxides', 'Dinoflagellida', 'Erythrocytes', 'Heparin', 'Palmitates', 'Plant Extracts', 'Rabbits', 'Spectrophotometry'] | 10,885,508 | [['B01.050'], ['E05.091'], ['B01.650.940.150'], ['D03.661.243'], ['B01.043.214'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D09.698.373.400'], ['D10.251.694.600'], ['D20.215.784.500', 'D26.667'], ['B01.050.150.900.649.313.968.700'], ['E05.196.712.726', 'E05.196.867.826']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Oxa1 protein forms a homooligomeric complex and is an essential part of the mitochondrial export translocase in Neurospora crassa. | The Oxa1 protein is a ubiquitous constituent of the inner membrane of mitochondria. Oxa1 was identified in yeast as a crucial component of the protein export machinery known as the OXA translocase, which facilitates the integration of proteins from the mitochondrial matrix into the inner membrane. We have identified th... | ['Amino Acid Sequence', 'Base Sequence', 'Biopolymers', 'DNA Primers', 'Detergents', 'Electron Transport Complex IV', 'Genetic Complementation Test', 'Mitochondria', 'Mitochondrial Proteins', 'Molecular Sequence Data', 'Neurospora crassa', 'Nuclear Proteins', 'Sequence Homology, Amino Acid'] | 11,823,466 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D27.720.877.265', 'J01.516.381'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The economic burden of pervasive developmental disorders in a privately insured population. | The objective of this study was to compare health care costs and utilization in children with pervasive developmental disorders (PDDs), asthma, or diabetes. Data for this investigation were derived from a large U.S. commercial insurance plan. Total cost per child and number of outpatient claims were significantly highe... | ['Adolescent', 'Asthma', 'Child', 'Child Development Disorders, Pervasive', 'Child, Preschool', 'Cost of Illness', 'Diabetes Mellitus', 'Female', 'Health Services', 'Humans', 'Insurance, Health', 'Male', 'Private Sector', 'Retrospective Studies', 'United States'] | 16,933,527 | [['M01.060.057'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['F03.625.164'], ['M01.060.406.448'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['C18.452.394.750', 'C19.246'], ['N02.421'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. | A family of related proteins in yeast Saccharomyces cerevisiae is known to have in vitro GTPase-activating protein activity on the Rab GTPases. However, their in vivo function remains obscure. One of them, Gyp1p, acts on Sec4p, Ypt1p, Ypt7p, and Ypt51p in vitro. Here, we present data to reveal its in vivo substrate and... | ['Carboxypeptidases', 'Cathepsin A', 'Cell Fractionation', 'Fungal Proteins', 'GTPase-Activating Proteins', 'Genes, Reporter', 'Golgi Apparatus', 'Immunoblotting', 'Microscopy, Fluorescence', 'Protein Transport', 'Recombinant Fusion Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'rab GTP-Bi... | 11,359,917 | [['D08.811.277.656.350.245'], ['D08.811.277.656.224.062', 'D08.811.277.656.350.245.260', 'D08.811.277.656.959.200'], ['E05.242.251'], ['D12.776.354'], ['D12.644.360.325.150', 'D12.776.476.325.150'], ['G05.360.340.024.340.435'], ['A11.284.430.214.190.875.336'], ['E05.478.566.320', 'E05.601.470.320'], ['E01.370.350.515.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of attention on visuomotor activity in the premotor and prefrontal cortex of a primate. | We examined neuronal activity in the primate premotor (PM) and prefrontal (PF) areas during a demanding spatial matching task. On each behavioral trial, a rhesus monkey moved its forelimb when a visual stimulus, called the "prime stimulus," reappeared at a previously cued location. Because it triggered a movement, the ... | ['Animals', 'Attention', 'Brain Mapping', 'Macaca mulatta', 'Male', 'Motor Cortex', 'Neurons', 'Orientation', 'Pattern Recognition, Visual', 'Prefrontal Cortex', 'Psychomotor Performance', 'Saccades'] | 8,237,213 | [['B01.050'], ['F02.830.104.214'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['A08.675', 'A11.671'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.524... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CaMKII modulates sodium current in neurons from epileptic Scn2a | Monogenic epilepsies with wide-ranging clinical severity have been associated with mutations in voltage-gated sodium channel genes. In the Scn2aQ54 mouse model of epilepsy, a focal epilepsy phenotype is caused by transgenic expression of an engineered NaV1.2 mutation displaying enhanced persistent sodium current. Seizu... | ['Animals', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Epilepsy', 'HEK293 Cells', 'Hippocampus', 'Humans', 'Membrane Potentials', 'Mice, Inbred C57BL', 'Mice, Inbred Strains', 'Mice, Transgenic', 'Mutation', 'NAV1.2 Voltage-Gated Sodium Channel', 'Neurons', 'Patch-Clamp Techniques', 'Sodium'] | 28,137,877 | [['B01.050'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['C10.228.140.490'], ['A11.251.210.172.750', 'A11.436.334'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.56... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute memory deficits in chemotherapy-treated adults. | Data from research on amnesia and epilepsy are equivocal with regards to the dissociation, shown in animal models, between rapid and slow long-term memory consolidation. Cancer treatments have lasting disruptive effects on memory and on brain structures associated with memory, but their acute effects on synaptic consol... | ['Adolescent', 'Adult', 'Amnesia', 'Case-Control Studies', 'Drug Therapy', 'Drug-Related Side Effects and Adverse Reactions', 'Female', 'Humans', 'Male', 'Memory Disorders', 'Mental Recall', 'Middle Aged', 'Neuropsychological Tests', 'Verbal Learning', 'Young Adult'] | 28,285,570 | [['M01.060.057'], ['M01.060.116'], ['C10.597.606.525.100', 'C23.888.592.604.529.100', 'F01.700.625.100', 'F03.615.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E02.319'], ['C25.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes. | Cytosine and adenine base editors are promising new tools for introducing precise genetic modifications that are required to generate disease models and to improve traits in pigs. Base editors can catalyze the conversion of C?T (C>T) or A?G (A>G) in the target site through a single guide RNA. Injection of base editors ... | ['Alleles', 'Animals', 'Animals, Genetically Modified', 'Blastocyst', 'Cytoplasm', 'Cytosine', 'Embryo, Mammalian', 'Embryonic Development', 'Female', 'Fertilization', 'Fertilization in Vitro', 'Gene Editing', 'Genome', 'Male', 'Mutation', 'Oocytes', 'RNA, Guide', 'Swine'] | 31,974,864 | [['G05.360.340.024.340.030'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A16.254.500'], ['A11.284.430.214'], ['D03.383.742.698.421'], ['A16.254'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['G08.686.784.277'], ['E02.875.800.750', 'E05.820.800.750'], ['E05.393.420.270'], ['G05.360.340'], ['G05.365.590'], [... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of integrins by human trophoblast and differential adhesion to laminin or fibronectin. | The process of placental implantation involves a series of transformations of trophoblast from a single polarized epithelial layer resting on a basement membrane (villous trophoblast), to cellular aggregates (trophoblast columns) which ultimately disperse to invade uterine decidua as individual cells (interstitial trop... | ['Cell Adhesion', 'Cells, Cultured', 'Fibronectins', 'Flow Cytometry', 'Fluorescent Antibody Technique', 'Gene Expression', 'Humans', 'Immunohistochemistry', 'Integrins', 'Laminin', 'Trophoblasts'] | 8,473,471 | [['G04.022'], ['A11.251'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['E01.370.225.500.607.512.24... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Accumulation of plasma cells in inflamed sites: effects of antigen, nonspecific microbial activators, and chronic inflammation. | Plasma cells are common in chronically inflamed sites, including periodontal lesions. The aim of this study was to determine which factors contribute to this local accumulation of plasma cells. Specifically, we sought to evaluate the effects of specific antigen and nonspecific activators from an infectious agent associ... | ['Acute Disease', 'Adjuvants, Immunologic', 'Animals', 'Antibody-Producing Cells', 'Antigens', 'Cell Movement', 'Chronic Disease', 'Dose-Response Relationship, Immunologic', 'Fusobacterium nucleatum', 'Horseradish Peroxidase', 'Inflammation', 'Male', 'Periodontitis', 'Plasma Cells', 'Rabbits', 'Skin Diseases'] | 1,937,760 | [['C23.550.291.125'], ['D27.505.696.477.067'], ['B01.050'], ['A11.063', 'A15.382.032'], ['D23.050'], ['G04.198', 'G07.568.500.180'], ['C23.550.291.500'], ['G12.300'], ['B03.370.250.500', 'B03.440.425.410.420.500'], ['D08.811.682.732.512'], ['C23.550.470'], ['C07.465.714.533'], ['A11.063.438.725', 'A11.118.637.555.567.5... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endovenous laser ablation and concomitant foam sclerotherapy: experience in 504 patients. | PURPOSE: To investigate the value of endovenous laser ablation (ELA) and concomitant ultrasound-guided foam sclerotherapy (USGFS) in patients with chronic venous insufficiency.METHODS: During a 6-year period, concomitant USGFS of the varicose veins were performed in 504 out of 610 patients who underwent ELA for truncal... | ['Adult', 'Chronic Disease', 'Female', 'Humans', 'Laser Therapy', 'Leg', 'Male', 'Polidocanol', 'Polyethylene Glycols', 'Retrospective Studies', 'Saphenous Vein', 'Sclerosing Solutions', 'Sclerotherapy', 'Treatment Outcome', 'Ultrasonography, Doppler, Color', 'Ultrasonography, Interventional', 'Varicose Veins'] | 22,167,308 | [['M01.060.116'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['A01.378.610.500'], ['D02.033.455.250.700.670', 'D05.750.741.630', 'D25.720.741.630', 'J01.637.051.720.741.630'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['E05.318.3... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Scaling characteristics in ozone concentration time series (OCTS). | One-year series of hourly average ozone observations, which were obtained from urban and national park air monitoring stations at Taipei (Taiwan), were analyzed by means of descriptive statistics and fractal methods to examine the scaling structures of ozone concentrations. It was found that all ozone measurements exhi... | ['Environmental Monitoring', 'Fractals', 'Nonlinear Dynamics', 'Oxidants, Photochemical', 'Ozone', 'Taiwan', 'Time Factors'] | 16,081,138 | [['N06.850.460.350.080', 'N06.850.780.375'], ['E05.599.125', 'G17.290'], ['E05.599.850', 'H01.548.675'], ['D27.720.642.631', 'D27.888.569.540.631'], ['D01.362.670.600'], ['Z01.252.474.872', 'Z01.639.850'], ['G01.910.857']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The effect of chloroquine on the production of interferon-gamma, interleukin (IL)-4, IL-6, and IL-10 in Plasmodium chabaudi chabaudi in infected C57BL6 mice. | The effect of chloroquine (CQ) on the production pattern of interferon (IFN)-gamma, interleukin (IL)-4, IL-6, and IL-10 in female C57BL6 mice infected with Plasmodium chabaudi chabaudi AS was evaluated during a period of 35 days. Our data confirm that there is a switch from a T helper cell (Th)1 to a Th2 response durin... | ['Animals', 'Antimalarials', 'Chloroquine', 'Female', 'Interferon-gamma', 'Interleukin-10', 'Interleukin-4', 'Interleukin-6', 'Interleukins', 'Lymphocyte Activation', 'Malaria', 'Mice', 'Mice, Inbred C57BL', 'Parasitemia', 'Plasmodium chabaudi'] | 10,577,734 | [['B01.050'], ['D27.505.954.122.250.100.085'], ['D03.633.100.810.050.180'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Breast MRI at 7 Tesla with a bilateral coil and T1-weighted acquisition with robust fat suppression: image evaluation and comparison with 3 Tesla. | OBJECTIVES: To evaluate the image quality of T1-weighted fat-suppressed breast MRI at 7 T and to compare 7-T and 3-T images.METHODS: Seventeen subjects were imaged using a 7-T bilateral transmit-receive coil and 3D gradient echo sequence with adiabatic inversion-based fat suppression (FS). Images were graded on a five-... | ['Adipose Tissue', 'Adult', 'Breast', 'Breast Diseases', 'Diagnosis, Differential', 'Equipment Design', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Middle Aged', 'Reproducibility of Results', 'Signal-To-Noise Ratio', 'Young Adult'] | 23,896,763 | [['A10.165.114'], ['M01.060.116'], ['A01.236'], ['C17.800.090'], ['E01.171'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.37... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Gender differences in health promotion behaviors and quality of life among community-dwelling elderly. | The differences of basic attributes, health promotion behaviors, and quality of life between elderly males and females in Taiwan were compared. Several scales were used to examine the gender differences and the factors associated with quality of life. Regression analysis revealed that gender, education level, depressio... | ['Aged', 'Aged, 80 and over', 'Depression', 'Diet, Healthy', 'Educational Status', 'Female', 'Health Behavior', 'Health Promotion', 'Health Status', 'Humans', 'Independent Living', 'Male', 'Personal Satisfaction', 'Quality of Life', 'Regression Analysis', 'Sex Factors', 'Taiwan'] | 28,375,707 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.126.350'], ['F01.829.458.205.500', 'G07.203.650.240.629'], ['N01.824.196'], ['F01.145.488'], ['I02.233.332.445', 'N02.421.726.407.579'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.050.500', 'N01.2... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Urokinase plasminogen activator and its inhibitor type-1 as prognostic factors in differentiated thyroid carcinoma patients. | OBJECTIVE: To investigate the prognostic value of urokinase-type plasminogen activator (uPA) and its inhibitor, type-1 plasminogen activator inhibitor (PAI-1), in differentiated thyroid cancer.STUDY DESIGN: Prospective cohort study.SETTING: University hospital.SUBJECTS AND METHODS: Cytosolic concentrations of uPA and P... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Disease Progression', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Plasminogen Activator Inhibitor 1', 'Prognosis', 'Prospecti... | 23,835,563 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.656'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution. | Hantavirus cardiopulmonary syndrome (HCPS) is characterized by capillary leak, pulmonary edema (PE), and shock, which leads to death in up to 40% of patients. Treatment is supportive, including mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO). Hemodynamic monitoring is critical to titrate ther... | ['Adolescent', 'Adult', 'Capillary Permeability', 'Female', 'Hantavirus', 'Hantavirus Infections', 'Hemodynamics', 'Humans', 'Lung', 'Male', 'Middle Aged', 'Permeability', 'Pulmonary Edema', 'Retrospective Studies', 'Stroke Volume', 'Thermodilution', 'Young Adult'] | 31,569,646 | [['M01.060.057'], ['M01.060.116'], ['G03.143.330', 'G09.330.165'], ['B04.820.480.750.440'], ['C01.925.782.147.420'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['M01.060.116.630'], ['G02.723'], ['C08.381.742'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Contributions of postrhinal and perirhinal cortex to contextual information processing. | The role of the postrhinal cortex (POR) and the perirhinal cortex (PER) in processing relational or contextual information was examined with Pavlovian fear conditioning. Rats with electrolytic or neurotoxic lesions of the POR or PER were tested in 2 contextual fear conditioning paradigms. In Experiment 1, electrolytic ... | ['Animals', 'Behavior, Animal', 'Cognition', 'Conditioning, Classical', 'Environment', 'Fear', 'Male', 'Memory', 'Olfactory Pathways', 'Rats', 'Rats, Long-Evans'] | 11,085,602 | [['B01.050'], ['F01.145.113'], ['F02.463.188'], ['F02.463.425.179.308'], ['G16.500.275', 'N06.230'], ['F01.470.361'], ['F02.463.425.540'], ['A08.186.211.180.699', 'A08.612.220.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.500']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Design and Synthesis of Soluble and Cell-Permeable PI3Kä Inhibitors for Long-Acting Inhaled Administration. | PI3Kä is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesized to provide a powerful yet selective immunomodulatory effect that may be beneficial for the treatment of conditions such as asthma or rheumatoid arthritis. In this work, we d... | ['Administration, Inhalation', 'Animals', 'Biological Availability', 'Chemistry Techniques, Synthetic', 'Drug Design', 'Drug Evaluation, Preclinical', 'Enzyme Inhibitors', 'Half-Life', 'Isoenzymes', 'Mice, Transgenic', 'Permeability', 'Phosphoinositide-3 Kinase Inhibitors', 'Rats', 'Solubility', 'Structure-Activity Rel... | 28,520,415 | [['E02.319.267.050'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['E05.197', 'J01.897.836.249'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.290.750', 'E05.337.550'], ['D27.505.519.389'], ['G01.910.405'], ['D08.811.348', 'D12.776.800.300'], ['B01.050.050.136.500', 'B01.050.150.900.649... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Effect of er-xian decoction and its disassembled prescription on enzyme activities and their gene expression of antioxidant enzymes in aging rat]. | In order to study the mechanism of aging, this experiment adopted molecular biological techniques to observe the effect of Er-Xian decoction (EXD)and its disassembled prescription on the enzyme activities and their gene expression of superoxide dismutase (SOD)and catalase (CAT). The results showed that in old rat, the ... | ['Aging', 'Animals', 'Catalase', 'Drugs, Chinese Herbal', 'Female', 'Free Radical Scavengers', 'Gene Expression', 'Genes, myc', 'Lipid Peroxides', 'Liver', 'Male', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Superoxide Dismutase'] | 8,732,154 | [['G07.345.124'], ['B01.050'], ['D08.811.682.732.332'], ['D20.215.784.500.350', 'D26.335'], ['D27.505.519.217.500'], ['G05.297'], ['G05.360.340.024.340.375.500.791.420'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['A03.620'], ['D13.444.735.544'], ['B01.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration. | In the present studies, we have established that RSV can elicit a more pathogenic environment dependent on improper DC-associated sensitization. Our initial studies demonstrated that RSV, but not influenza, infection during an allergen exposure into the airway induced a more severe allergen response. The RSV-induced ex... | ['Allergens', 'Animals', 'Cell Movement', 'Dendritic Cells', 'Female', 'Flow Cytometry', 'Lung Diseases', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Receptors, CCR6', 'Respiratory Syncytial Virus Infections', 'Respiratory Syncytial Viruses'] | 23,293,372 | [['D23.050.063'], ['B01.050'], ['G04.198', 'G07.568.500.180'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['C08.381'], ['B... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. | In eukaryotes, selective derepression of mRNA translation through altered utilization of upstream open reading frames (uORF) or internal ribosomal entry sites (IRES) regulatory motifs following exposure to stress is regulated at the initiation stage through the increased phosphorylation of eukaryotic initiation factor ... | ['Animals', 'Blotting, Western', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme Activation', 'Female', 'Hydroquinones', 'Liver', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred Strains', 'Mice, Knockout', 'Oligonucleotide Array Sequence Analysis', 'Protein Biosynthesis', 'Protein-Serine-Threonine Kinases', 'RNA, Me... | 19,509,078 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.196.401.402', 'E05.301.300.319'], ['G02.111.263', 'G03.328'], ['D02.455.426.559.389.657.393'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.9... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Duplex sonography of the vertebral arteries. 2. Clinical application]. | The purpose of this report is to demonstrate pathological findings such as hypoplasia, stenosis and occlusion that were diagnosed by duplex-ultrasonography of vertebral arteries. Duplex scanning provides complementary to the continuous wave Doppler examination more accurate haemodynamical and morphological information ... | ['Blood Flow Velocity', 'Constriction, Pathologic', 'Humans', 'Image Processing, Computer-Assisted', 'Subclavian Steal Syndrome', 'Ultrasonography', 'Vascular Resistance', 'Vertebral Artery', 'Vertebrobasilar Insufficiency'] | 1,871,572 | [['E01.370.370.130', 'G09.330.380.630.080'], ['C23.300.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['C10.228.140.300.150.956.700', 'C14.907.253.092.956.700'], ['E01.370.350.850'], ['G09.330.380.921'], ['A07.015.114.955'], ['C10.228.140.300.150.956', 'C14.907.253.092.956']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Demonstration of Epstein-Barr virus genomes, using polymerase chain reaction in situ hybridization in paraffin-embedded lymphoid tissues. | We used the polymerase chain reaction (PCR) in situ hybridization (ISH) (PCR-ISH) on sections of malignant lymphoma and nonspecific lymphadenitis to detect small amounts of Epstein-Barr virus (EBV), a DNA virus of the herpes virus family. We first surveyed the EBV DNA by Southern blot analysis and PCR, and then compare... | ['Base Sequence', 'Blotting, Southern', 'Herpesvirus 4, Human', 'Humans', 'In Situ Hybridization', 'Lymphoid Tissue', 'Lymphoma', 'Molecular Sequence Data', 'Paraffin Embedding', 'Polymerase Chain Reaction', 'Tumor Virus Infections'] | 7,567,683 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prognostic significance and optimal cutoff of age in medullary thyroid cancer. | Age has been found to correlate with the prognosis for medullary thyroid cancer (MTC). This study was conducted to investigate whether age can predict long-term unfavorable prognosis and evaluate its predictive accuracy associated with TNM staging, using data of patients diagnosed with MTC between 2000 and 2010 from Su... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Carcinoma, Neuroendocrine', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nomograms', 'Prognosis', 'Proportional Hazards Models', 'Risk Factors', 'SEER Program', 'Thyroid Neoplasms', 'Young Adult'] | 26,910,117 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.465.625.650.240', 'C04.557.470.200.025.370', 'C04.557.580.625.650.240'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.78... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evolutionary relationships among the true vipers (Reptilia: Viperidae) inferred from mitochondrial DNA sequences. | Nucleotide sequences of mitochondrial cytochrome b and 16S rRNA genes, totaling 946 bp, were used to reconstruct a molecular phylogeny of 42 species of the subfamily Viperinae representing 12 of the 13 recognized genera. Maximum-parsimony and maximum-likelihood were used as methods for phylogeny reconstruction with and... | ['Animals', 'Cytochrome b Group', 'DNA, Mitochondrial', 'Evolution, Molecular', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Viperidae'] | 11,286,494 | [['B01.050'], ['D08.244.187', 'D12.776.422.220.187'], ['D13.444.308.283.225'], ['G05.045.250', 'G16.075.250'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686.670'], ['E05.393.760.700'], ['B01.050.150.900.833.672.125.937']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Klinefelter syndrome in a boy with symptoms of precocious puberty]. | Klinefelter syndrome is one of the most frequent sex chromosomal aberration. It is usually not recognized before puberty and many patients remain never diagnosed. Delayed puberty and hypergonadotropic hypogonadism are typical in this syndrome. Early diagnosis and therapy with androgens is important for patients. We pre... | ['Early Diagnosis', 'Humans', 'Klinefelter Syndrome', 'Male', 'Poland', 'Puberty, Precocious', 'Treatment Outcome'] | 25,612,816 | [['E01.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.706.316.795.500', 'C13.351.875.253.795.500', 'C16.131.260.830.835.500', 'C16.131.939.316.795.500', 'C16.320.180.830.835.500', 'C19.391.119.795.500', 'C19.391.482.629'], ['Z01.542.248.679'], ['C19.391.693'], ['E01.789.800', 'N04.761.559.590.800', 'N05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Cross-sectional study on fecal carriage of Enterobacteriaceae with resistance to extended-spectrum cephalosporins in primary care patients. | The aim of this study was to gain knowledge of the local epidemiology of extended-spectrum cephalosporin-resistant bacteria in primary care patients in a Swiss community. Fecal swabs were obtained from 291 primary care patients. Phenotyping and genotyping methods were used for further characterization of the isolates. ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Bacterial Typing Techniques', 'Cephalosporins', 'Cross-Sectional Studies', 'Enterobacteriaceae', 'Enterobacteriaceae Infections', 'Feces', 'Female', 'Humans', 'Male', 'Middle Aged', 'Primary Health Care', 'Switzerland', 'beta-Lactam Resistance', 'beta-Lac... | 23,611,297 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B03.440.450.425', 'B03.660.250.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Effects of ginkgo leave concentrated oral liquor in treating asthma]. | OBJECTIVE: To determine the effects of Ginkgo leave concentrated oral liquor (GLC) on airway inflammation.METHODS: Airway hyperreactivity and clinical symptoms and pulmonary functions of asthma patients were determined.RESULTS: In contrast to placebo group, GLC significantly reduced airway hyperreactivity (P < 0.05) an... | ['Adolescent', 'Adult', 'Asthma', 'Bronchial Hyperreactivity', 'Cycadopsida', 'Diterpenes', 'Drugs, Chinese Herbal', 'Female', 'Fibrinolytic Agents', 'Ginkgo biloba', 'Ginkgolides', 'Humans', 'Lactones', 'Male', 'Phytotherapy', 'Plant Leaves', 'Plants, Medicinal', 'Respiratory Function Tests'] | 9,863,095 | [['M01.060.057'], ['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C08.127.210'], ['B01.650.940.800.575.156'], ['D02.455.849.291'], ['D20.215.784.500.350', 'D26.335'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.650.940.800.575.912.125'], ['D0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synthesis and antifungal activities of novel 5-amino-6-arylamino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives. | A novel approach was developed to regioselectively synthesize new 5-amino-6-arylamino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 5 derivatives via a tandem aza-Wittig and annulation reactions of iminophosphorane 2, aromatic isocyanates, and hydrazine in 52-92% isolated yields. The compounds 5 reacted with triethyl orthoform... | ['Antifungal Agents', 'Ascomycota', 'Botrytis', 'Crystallization', 'Crystallography, X-Ray', 'Molecular Structure', 'Pyrazoles', 'Pyrimidines', 'Triazoles'] | 18,672,885 | [['D27.505.954.122.136'], ['B01.300.107'], ['B01.300.381.128'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['G02.111.570', 'G02.466'], ['D03.383.129.539'], ['D03.383.742'], ['D03.383.129.799']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rabbit DQ52 and DH gene expression in early B-cell development. | Rabbits predominantly rearrange the most 3'VH gene (VH1); thus combinatorial diversity is very limited. In man and mouse, the most 3'DH gene, DQ52, is preferentially rearranged early in B-cell development. To test whether this preference for rearranging a DH gene segment based on 3' end proximity exists in rabbit, we c... | ['Amino Acid Sequence', 'Animals', 'B-Lymphocytes', 'Base Sequence', 'Cell Differentiation', 'Cloning, Molecular', 'DNA, Complementary', 'Fetus', 'Gene Expression Regulation', 'Gene Rearrangement, B-Lymphocyte, Heavy Chain', 'Genes, Immunoglobulin', 'Germ Cells', 'Haplotypes', 'Humans', 'Immunoglobulin Variable Region'... | 9,171,891 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.152'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Study on Identification of Immature Corn Seed Using Hyperspectral Imaging]. | The seed maturity, which is one of the important factors that affect seed vigor, is an important quality index. During seed sorting, separating mature seeds from immature seeds can improve the vigor of seed lot and keep vigor consistency. Hyperspectral imaging that covered the range of 400~1 000 nm was used to find out... | ['Algorithms', 'Least-Squares Analysis', 'Principal Component Analysis', 'Seeds', 'Zea mays'] | 30,243,269 | [['G17.035', 'L01.224.050'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.318.740.562'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['B01.650.940.800.575.912.250.822.966']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Rare-region effects in the contact process on networks. | Networks and dynamical processes occurring on them have become a paradigmatic representation of complex systems. Studying the role of quenched disorder, both intrinsic to nodes and topological, is a key challenge. With this in mind, here we analyze the contact process (i.e., the simplest model for propagation phenomena... | ['Algorithms', 'Computer Simulation', 'Models, Biological', 'Models, Statistical'] | 23,005,180 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['E05.599.395'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Non-paroxysmal arterioventricular junctional tachycardia during postprandial hypoglycaemia in an obese non-diabetic patient. | We have observed the simultaneous occurrence of postprandial hypoglycaemia and a rare cardiac arrhythmia: non-paroxysmal arteriovenous junctional tachycardia (NPJT) in a patient with suspected coronary heart disease (CHD) submitted to oral glucose tolerance testing (OGTT). To our knowledge the association between hypog... | ['Aged', 'Female', 'Humans', 'Hypoglycemia', 'Myocardial Ischemia', 'Obesity', 'Tachycardia, Supraventricular'] | 8,354,984 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['C14.280.647', 'C14.907.585'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C14.280.067.845.880', 'C14.280.123.875.880', 'C23.550.073.845.880']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Binding properties of protein Arp, a bacterial IgA-receptor. | A cell surface receptor that binds to the Fc region of IgA is expressed by certain strains of group A streptococci. The physico-chemical properties and binding characteristics of this receptor, called protein Arp, were studied. Like bacterial receptors that bind IgG, protein Arp has an elongated shape and no disulfide ... | ['Bacterial Proteins', 'Hydrogen-Ion Concentration', 'Immunoglobulin A', 'Immunoglobulin G', 'In Vitro Techniques', 'Molecular Weight', 'Peptide Fragments', 'Receptors, Fc', 'Receptors, Immunologic', 'Recombinant Proteins', 'Species Specificity', 'Streptococcus pyogenes'] | 2,062,317 | [['D12.776.097'], ['G02.300'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.776.377.715.548.114.619.026'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['E05.481'], ['G02.494'], ['D12.644.541'], ['D12.776.543.750.705.871'], ['D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutation of alpha-tubulin genes in trifluralin-resistant water foxtail (Alopecurus aequalis). | BACKGROUND: Trifluralin-resistant biotypes of water foxtail (Alopecurus aequalis) have been identified in wheat fields from northern Kyushu, Japan. Water foxtail is a winter-annual grassy weed, causing substantial crop losses. This study reports on mutation in á-tubulin (TUA) genes from water foxtail, the site of actio... | ['Amino Acid Sequence', 'Base Sequence', 'Herbicide Resistance', 'Herbicides', 'Molecular Sequence Data', 'Mutation', 'Plant Proteins', 'Poaceae', 'Trifluralin', 'Tubulin'] | 21,972,152 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G07.690.773.984.443'], ['D27.720.031.700.366', 'D27.888.723.366'], ['L01.453.245.667'], ['G05.365.590'], ['D12.776.765'], ['B01.650.940.800.575.912.250.822'], ['D02.092.146.859.717', 'D02.455.426.559.389.832.767'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
SF3B1 | Mutations in the RNA splicing gene SF3B1 are found in >80% of patients with myelodysplastic syndrome with ring sideroblasts (MDS-RS). We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. Screening for recurrently mutated genes ... | ['Aged', 'Aged, 80 and over', 'Animals', 'Cell Differentiation', 'Female', 'Hematopoietic Stem Cells', 'Humans', 'Lymphocytes', 'Male', 'Mice', 'Middle Aged', 'Mutation', 'Myelodysplastic Syndromes', 'Myeloid Cells', 'Phosphoproteins', 'RNA Splicing Factors', 'Spliceosomes'] | 28,634,182 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['G04.152'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['B01.050.150.900.649.313.992.635.505.500'], ['M01.060.116.630'], ['G05.... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells. | Selective targeting of cancer cells employing multiple combinations as co-drug holds promise for new generation therapeutics. Betulinic acid (BA), a plant secondary metabolite kills cancer cells and Dichloroacetate (DCA) is capable of reversing the Warburg phenotype by inhibiting pyruvate dehydrogenase kinase (PDK). He... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Caspases', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Dichloroacetic Acid', 'Disease Models, Animal', 'Drug Synergism', 'Esters', 'Female', 'Humans', 'Inhibitory Concentration 50', 'Lung Neoplasms', 'Melanoma', 'Membrane Potential, Mitochondrial', 'Mic... | 25,585,916 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['D02.241.081.018.214.500', 'D02.455.526.439.196.500'], ['C22... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipopolysaccharide Alters Thermogenic and Inflammatory Genes in White Adipose Tissue in Mice Fed Diets with Distinct 18-Carbon Fatty-Acid Composition. | Fatty acids are involved in the regulation of inflammatory responses in obesity. However, despite being the largest dietary fatty-acid class, effects of 18-carbon fatty acids with different degrees of saturation on inflammatory, metabolic, and thermogenic markers have not been well studied. Therefore, the objective of ... | ['Adipose Tissue, White', 'Animals', 'Carbon Radioisotopes', 'Cytokines', 'Diet, High-Fat', 'Down-Regulation', 'Fatty Acids', 'Inflammation', 'Lipopolysaccharides', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Thermogenesis', 'Up-Regulation'] | 30,460,700 | [['A10.165.114.830'], ['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.203.650.240.267'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D10.251'], ['C23.550.470'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.61... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A case report of postoperative thyroid crisis accompanied with struma ovarii]. | A 39-year-old female without any specific past history was scheduled to receive an operation for myoma uteri and ovarian cyst. She was premedicated with atropine. Anesthesia was induced with thiopental and was maintained with nitrous oxide and enflurane. Tachycardia shortly after premedication with atropine and remarka... | ['Adult', 'Female', 'Humans', 'Ovarian Neoplasms', 'Postoperative Complications', 'Struma Ovarii', 'Thyroid Crisis'] | 2,345,402 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['C23.550.767'], ['C04.557.465.910.850'], ['C19.874.397.685.905']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Kearns-Sayre syndromes an absolute indication for prophylactic implantation of definitive pacemaker? | Kearns-Sayre syndrome is a mitochondrial cytopathy characterized by chronic progressive external ophthalmoplegia, retinitis pigmentosa and heart block, the last of which determines the survival of these patients. The case of a 23 year old man with Kearns-Sayre syndrome, conduction disturbances and mitral valve prolapse... | ['Adult', 'Bundle-Branch Block', 'Humans', 'Kearns-Sayre Syndrome', 'Male', 'Pacemaker, Artificial'] | 10,742,853 | [['M01.060.116'], ['C14.280.067.558.323', 'C14.280.123.500.323', 'C23.550.073.425.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.651.460.700.500', 'C10.292.562.750.250.500', 'C10.597.622.447.511.500', 'C10.668.491.500.700.500', 'C11.590.472.250.500', 'C11.768.585.658.500.627', 'C14.280.238.510', 'C18.452... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape. | The typical bullet shape of Rhabdoviruses is thought to rely on the matrix protein for stabilizing the nucleocapsid coil. Here we scrutinize the morphology of purified and recombinant nucleocapsids of vesicular stomatitis virus in vitro. We elucidate pH and ionic strength conditions for their folding into conical tips ... | ['Cryoelectron Microscopy', 'Nucleic Acid Conformation', 'Nucleocapsid', 'Nucleoproteins', 'RNA, Viral', 'Vesicular stomatitis Indiana virus', 'Viral Matrix Proteins'] | 23,385,574 | [['E01.370.350.515.402.150', 'E05.595.402.150'], ['G02.111.570.820.486', 'G05.360.580'], ['A21.249.500'], ['D12.776.664'], ['D13.444.735.828'], ['B04.820.480.937.750.900.900'], ['D12.776.964.970.880.940']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Late effects of proximal gastric vagotomy compared with antrectomy and selective vagotomy for chronic duodenal ulcer. A randomized study with 5-year follow-up. | Twenty-three patients who had been given a proximal gastric vagotomy and 29 patients who had had an antrectomy were examined periodically for 5 years after their operations for duodenal ulcers. Five years after surgery, 83% of the proximal gastric vagotomy patients and 86% of the antrectomy and selective vagotomy patie... | ['Adult', 'Aged', 'Bone and Bones', 'Chronic Disease', 'Duodenal Ulcer', 'Female', 'Follow-Up Studies', 'Humans', 'Intestinal Absorption', 'Male', 'Middle Aged', 'Minerals', 'Prospective Studies', 'Pyloric Antrum', 'Random Allocation', 'Vagotomy, Proximal Gastric'] | 4,051,446 | [['M01.060.116'], ['M01.060.116.100'], ['A02.835.232', 'A10.165.265'], ['C23.550.291.500'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Molecular Dynamics Simulations of Self-organization of the Structure of Model Biomimetic Polymers]. | By using the molecular dynamics method the problem of macromolecules' folding into spatial structures is examined. The freely jointed polymer chain with strong covalent bonds where van-der-Waals forces act between the units of the chain is considered. Conditions for the formation of different spatial structures resembl... | ['Biomimetic Materials', 'Models, Chemical', 'Molecular Conformation', 'Molecular Dynamics Simulation', 'Polymers', 'Thermodynamics', 'Time Factors'] | 26,349,205 | [['J01.637.087'], ['E05.599.495'], ['G02.111.570.820'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.906'], ['G01.910.857']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Ocular effects and systemic absorption of cyclopentolate eyedrops after canthal and conventional application. | Ocular effects and plasma concentrations of cyclopentolate were studied in 8 volunteers after eyedrop application with two methods. While recumbent two 30 microliters drops of 1% cyclopentolate hydrochloride were instilled in randomized order either conventionally to the lower conjunctival cul-de-sac or on the inner ca... | ['Absorption', 'Adult', 'Conjunctiva', 'Cyclopentolate', 'Eye', 'Eyelids', 'Female', 'Humans', 'Male', 'Ophthalmic Solutions', 'Posture', 'Pupil'] | 7,747,578 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['M01.060.116'], ['A09.371.060.200', 'A09.371.337.168'], ['D02.241.223.601.200'], ['A01.456.505.420', 'A09.371'], ['A01.456.505.420.504', 'A09.371.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.776.708.645', 'D27.505.954.578.645', 'D27... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alpha 1-antitrypsin polymerization: a fluorescence correlation spectroscopic study. | Alpha(1)-antitrypsin (AT) is the most abundantly circulating human proteinase inhibitor in the serpin family. The polymerization of AT, leading to alpha(1)-antitrypsin deficiency, has been studied extensively in vitro by a variety of ensemble methods. Here we report the use of fluorescence correlation spectroscopy to g... | ['Cysteine', 'Diffusion', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Microscopy, Confocal', 'Mutagenesis, Site-Directed', 'Peptide Fragments', 'Polymers', 'Protein Denaturation', 'Serine', 'Spectrometry, Fluorescence', 'Temperature', 'Time Factors', 'alpha 1-Antitrypsin'] | 15,709,777 | [['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G01.202', 'G02.196'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['E05.393.420.601.575'], ['D12.644.541'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Oral bromovinyldeoxyuridine therapy for herpes simplex and varicella-zoster virus infections in severely immunosuppressed patients: a preliminary clinical trial. | Twenty-five patients with haematological diseases were treated orally with the highly potent and selective anti-herpes agent, bromovinyldeoxyuridine (BVDU), in a dosage of 7.5 mg/kg/day (divided over three or four doses a day) for 5 days for an intercurrent mucocutaneous herpesvirus infection. Of these 25 patients, 8 w... | ['Adolescent', 'Adult', 'Aged', 'Antineoplastic Agents', 'Antiviral Agents', 'Bromodeoxyuridine', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Female', 'Herpes Simplex', 'Herpes Zoster', 'Humans', 'Immunosuppression', 'Leukemia', 'Lymphoma', 'Male', 'Middle Aged'] | 3,511,181 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D27.505.954.122.388'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['C01.925.256.466.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Temporary and permanent NiTi stents in percutaneous surgery for ureteropelvic segment stricture]. | A total of 18 roentgenoendoscopic percutaneous interventions for strictures of the ureteropelvic segment (UPS) have been made by the authors from the beginning of 2004: in 15 (83.3%) females and 3 (16.7%) males aged 16-48 years. Recurrent strictures developed in 11 (61.1%) patients after operations by Kuchere, Pristlay... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Intubation', 'Male', 'Middle Aged', 'Remission Induction', 'Retrospective Studies', 'Stents', 'Treatment Outcome', 'Ureteroscopy', 'Urethral Stricture'] | 17,915,445 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.585', 'E05.497'], ['M01.060.116.630'], ['E02.860'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825']... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evolutionary constraints in fitness landscapes. | In the last years, several genotypic fitness landscapes-combinations of a small number of mutations-have been experimentally resolved. To learn about the general properties of "real" fitness landscapes, it is key to characterize these experimental landscapes via simple measures of their structure, related to evolutiona... | ['Epistasis, Genetic', 'Evolution, Molecular', 'Genetic Fitness', 'Selection, Genetic'] | 29,993,041 | [['G05.308.207'], ['G05.045.250', 'G16.075.250'], ['G05.347'], ['G05.783']] | ['Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low-dose chronic prenatal alcohol exposure abolishes the pro-cognitive effects of angiotensin IV. | Prenatal ethanol exposure (PAE) in humans results in a spectrum of disorders including deficits in learning and memory. Animal models to date have typically used high ethanol doses but have not identified the biochemical changes underlying the cognitive deficit. This study used treatment of mouse breeding harems with 5... | ['Angiotensin II', 'Animals', 'Body Weight', 'Central Nervous System Depressants', 'Cognition Disorders', 'Ethanol', 'Exploratory Behavior', 'Female', 'Locomotion', 'Male', 'Maze Learning', 'Mice', 'Mice, Inbred C57BL', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Recognition, Psychology', 'Sex Factors', 'Statist... | 28,457,883 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D27.505.696.277', 'D27.505.954.427.210'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Benefit of bilateral cochlear implantation on congenital prelingually deafened Chinese-speaking children]. | OBJECTIVE: To evaluate the benefit of bilateral cochlear implants (BCIs) in prelingually deafened children on hearing rehabilitation as well as on speech and language development.METHOD: Two cases of congenital profound deaf children, who received unilateral cochlear implantation (CI, MEDEL C40+) on the age of 2 and 7.... | ['Child', 'Cochlear Implantation', 'Hearing Loss, Bilateral', 'Humans', 'Language Development', 'Speech Discrimination Tests', 'Speech Perception', 'Speech Reception Threshold Test', 'Treatment Outcome'] | 14,727,421 | [['M01.060.406'], ['E04.580.450.220', 'E04.650.220'], ['C09.218.458.341.374', 'C10.597.751.418.341.374', 'C23.888.592.763.393.341.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.525.200.310'], ['E01.370.382.375.060.060.750'], ['F02.463.593.071.875', 'G07.888.125.875'], ['E01.370.382.375.060.060.760'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Traumatic hemipelvectomy before body image has developed. | Traumatic hemipelvectomy is rarely observed because very few patients have survived from the initial trauma. We describe one male child who survived from this massive trauma with a good functional outcome. The boy was 28 months old when he was accidentally struck by a truck. He had severe open trauma of the pelvis and ... | ['Adolescent', 'Child, Preschool', 'Hemipelvectomy', 'Humans', 'Male', 'Wounds and Injuries'] | 10,198,611 | [['M01.060.057'], ['M01.060.406.448'], ['E04.555.080.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The 2009 US federal cigarette tax increase and quitline utilization in 16 states. | BACKGROUND: On April 1, 2009, the federal cigarette excise tax increased from 39 cents to $1.01 per pack.METHODS: This study describes call volumes to 16 state quitlines, characteristics of callers and cessation outcomes before and after the tax.RESULTS: Calls to the quitlines increased by 23.5% in 2009 and more whites... | ['Adolescent', 'Adult', 'Aged', 'Federal Government', 'Female', 'Hotlines', 'Humans', 'Male', 'Middle Aged', 'Smoking', 'Smoking Cessation', 'State Government', 'Taxes', 'Time Factors', 'Tobacco', 'United States', 'Young Adult'] | 22,649,463 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['I01.409.137', 'I01.409.418.625', 'N03.540.348.500', 'N03.540.400.750'], ['N02.421.297.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.805'], ['F01.145.488.732'], ['I01.409.775', 'N03.540.348.875'], ['N03.219.900'], ['G01.91... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Familial mutagen sensitivities: are these the hallmarks of meiotic or mutator mutants in humans? | Mutagen hypersensitivity (MHS) has been found to be associated with abnormalities in DNA metabolic processes in many prokaryotic and eukaryotic organisms. The study of fibroblasts derived from humans with genetic diseases believed to have altered DNA metabolism, has also revealed patterns of MHS. In this paper results ... | ['Ataxia Telangiectasia', 'Cells, Cultured', 'Chromosome Aberrations', 'Chromosome Disorders', 'Humans', 'Intellectual Disability', 'Meiosis', 'Mitosis', 'Mutagens'] | 546,478 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. | Preeclampsia is a severe complication of pregnancy, characterized by hypertension, oxidative stress, and severe endothelial dysfunction. Antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin, play key pathophysiological roles in preeclampsia. Heme oxygenase-1 (HO-1) is a cytoprotectiv... | ['Blotting, Western', 'Cell Survival', 'Cells, Cultured', 'Chalcones', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Heme Oxygenase-1', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'NF-E2-Related Factor 2', 'Oxidative Stress', 'Pre-Eclampsia', 'Pregnancy', 'RNA', 'Reverse Transcriptase Polymerase Chain Reactio... | 25,667,213 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.346'], ['A11.251'], ['D02.522.818.222', 'D03.383.663.283.266.450.221', 'D03.633.100.150.266.450.221'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemangiosarcoma in cats: 53 cases (1992-2002). | OBJECTIVE: To characterize the biological behavior and prognostic factors associated with hemangiosarcoma in cats.DESIGN: Retrospective case series.ANIMALS: 53 cats with hemangiosarcoma.PROCEDURES: Data were retrieved from a state veterinary diagnostic laboratory, 3 veterinary colleges, and a private practice.RESULTS: ... | ['Animals', 'Behavior, Animal', 'Cat Diseases', 'Cats', 'Disease-Free Survival', 'Euthanasia, Animal', 'Female', 'Hemangiosarcoma', 'Male', 'Neoplasm Metastasis', 'Prognosis', 'Retrospective Studies', 'Risk Factors', 'Skin Neoplasms', 'Survival Analysis', 'Treatment Outcome'] | 18,081,524 | [['B01.050'], ['F01.145.113'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E02.760.905.199.249.750', 'E05.335', 'N02.421.585.905.199.500.750'], ... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phylogenetic analysis of nitrite, nitric oxide, and nitrous oxide respiratory enzymes reveal a complex evolutionary history for denitrification. | Denitrification is a facultative respiratory pathway in which nitrite (NO2(-)), nitric oxide (NO), and nitrous oxide (N2O) are successively reduced to nitrogen gas (N(2)), effectively closing the nitrogen cycle. The ability to denitrify is widely dispersed among prokaryotes, and this polyphyletic distribution has raise... | ['Archaea', 'Chromosome Mapping', 'Enzymes', 'Evolution, Molecular', 'Gene Transfer, Horizontal', 'Genetic Variation', 'Genome, Bacterial', 'Likelihood Functions', 'Metabolic Networks and Pathways', 'Nitric Oxide', 'Nitrites', 'Nitrous Oxide', 'Phylogeny', 'Proteobacteria', 'RNA, Ribosomal, 16S', 'Sequence Alignment'] | 18,614,527 | [['B02'], ['E05.393.183'], ['D08.811'], ['G05.045.250', 'G16.075.250'], ['G05.728.390'], ['G05.365'], ['G05.360.340.358.207'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['G03.493'], ['D01... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Neuroblastoma. Effect of genetic factors on prognosis and treatment. | BACKGROUND AND METHODS. Genetic analysis of tumor tissue has provided considerable insight into mechanisms of malignant transformation and progression. Neuroblastomas have been studied by cytogenetics, flow cytometry, and molecular genetic techniques, and these studies have identified several specific abnormalities tha... | ['Cell Line', 'Chromosome Aberrations', 'Chromosome Deletion', 'Chromosome Disorders', 'Gene Amplification', 'Genes, myc', 'Genetic Techniques', 'Humans', 'Infant', 'Neuroblastoma', 'Ploidies', 'Prognosis', 'Receptors, Cell Surface', 'Receptors, Nerve Growth Factor'] | 1,325,279 | [['A11.251.210'], ['C23.550.210', 'G05.365.590.175'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['C16.131.260', 'C16.320.180'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['G05.360.340.024.340.375.500.7... | ['Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
TMEM187-IRAK1 | Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs10... | ['Adult', 'Aged', 'Alleles', 'Arthritis, Rheumatoid', 'Chromosomes, Human, X', 'Disease Susceptibility', 'Female', 'France', 'Genetic Predisposition to Disease', 'Geography', 'HLA-DR Antigens', 'HLA-DRB1 Chains', 'Haplotypes', 'Humans', 'Interleukin-1 Receptor-Associated Kinases', 'Membrane Proteins', 'Meta-Analysis as... | 28,271,077 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A11.284.187.520.300.325.680', 'A11.284.187.865.982.500', 'G05.360.162.520.300.325.680', 'G05.360.162.865.982.500'], ['C23.550.291.687', 'G07.100.250'], ['Z01.542.286'], ['C23.550.2... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Listening to carers' views on stroke services. | AIM: The aim of this study was to explore how members of a stroke carers' support group perceived that services for stroke patients and their carers could be improved.METHOD: A qualitative, experience-based design approach was used to explore the views of ten carers of stroke survivors. Experience questionnaires and a ... | ['Aged', 'Caregivers', 'Female', 'Humans', 'Male', 'Middle Aged', 'Stroke', 'United Kingdom'] | 24,471,551 | [['M01.060.116.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.300.775', 'C14.907.253.855'], ['Z01.542.363']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Strontium ranelate-induced DRESS syndrome]. | INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe form of adverse drug reaction. Strontium ranelate has recently been authorised for postmenopausal osteoporosis. We report a case of strontium ranelate-induced DRESS complicated by linear Ig A dermatosis due to vancomycin.CA... | ['Aged', 'Anti-Bacterial Agents', 'Anti-Inflammatory Agents', 'Bacteremia', 'Biopsy', 'Bone Density Conservation Agents', 'Chemical and Drug Induced Liver Injury', 'Drug Eruptions', 'Eosinophilia', 'Female', 'Fluorescent Antibody Technique, Direct', 'Humans', 'Immunoglobulin A', 'Methicillin-Resistant Staphylococcus au... | 21,333,824 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['D27.505.954.158'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D27.505.696.242'], ['C06.552.100', 'C25.100.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between major depressive disorder and associated painful physical symptoms: analysis of data from two pooled placebo-controlled, randomized studies of duloxetine. | The aim of this study was to evaluate the relationship between painful physical symptoms (PPS) and outcomes in major depressive disorder (MDD). Post-hoc analysis of two identically designed 8-week trials compared the efficacy of 60 mg/day duloxetine (N=523) with that of placebo (N=532) in treating PPS associated with M... | ['Adult', 'Analgesics', 'Antidepressive Agents', 'Depressive Disorder, Major', 'Double-Blind Method', 'Duloxetine Hydrochloride', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Statistics as Topic', 'Thiophenes'] | 23,873,291 | [['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D27.505.954.427.700.122'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.886.778.260', 'D03.383.903.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Emblica officinalis: a novel therapy for acute pancreatitis--an experimental study. | Acute necrotising pancreatitis is associated with an unacceptably high mortality for which no satisfactory remedy exists. Emblica officinalis (E.o.) is a plant prescribed in Ayurveda, the Indian traditional system of medicine, for pancreas-related disorders. This study was carried out to evaluate the protective effect ... | ['Acute Disease', 'Amylases', 'Animals', 'Dogs', 'Female', 'Male', 'Medicine, East Asian Traditional', 'Microscopy, Electron', 'Pancreatitis', 'Plant Extracts', 'Treatment Outcome'] | 8,857,450 | [['C23.550.291.125'], ['D08.811.277.450.066'], ['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.190.488.585', 'I01.076.201.450.654.558'], ['E01.370.350.515.402', 'E05.595.402'], ['C06.689.750'], ['D20.215.784.500', 'D26.667'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Fucose-targeted glycoengineering of pharmaceutical cell lines. | Glycosylation is known to have an impact on pharmacokinetics and pharmacodynamics of therapeutic proteins. While the production of pharmaceutically desirable glycosylation forms of a therapeutic protein can in certain cases be influenced by the upstream process parameters, certain specialized glycan structures can only... | ['Animals', 'Batch Cell Culture Techniques', 'Birds', 'Cell Line', 'Cloning, Molecular', 'Fucose', 'Glycosylation', 'Immunoglobulin G', 'Metabolic Engineering', 'Molecular Weight', 'N-Acetylneuraminic Acid', 'Pharmaceutical Preparations', 'Polysaccharides', 'Reverse Transcriptase Polymerase Chain Reaction', 'Spectromet... | 22,907,371 | [['B01.050'], ['E05.481.500.249.124'], ['B01.050.150.900.248'], ['A11.251.210'], ['E05.393.220'], ['D09.254.488'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['E05.393.420.526', 'E05.481.500.311.249', 'J01... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Transient versus Permanent Congenital Hypothyroidism after the Age of 3 Years in Infants Detected on the First versus Second Newborn Screening Test in Oregon, USA. | BACKGROUND/AIMS: The newborn screening (NBS) program in Oregon, USA, collects two routine specimens in all infants. The aim of our study was to determine the incidence of permanent versus transient congenital hypothyroidism (CH) in infants detected on the first versus second screening test.METHODS: Thyroid function was... | ['Child, Preschool', 'Congenital Hypothyroidism', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mass Screening', 'Oregon', 'Sex Factors', 'Thyrotropin', 'Thyroxine'] | 27,595,483 | [['M01.060.406.448'], ['C05.116.099.343.347', 'C05.116.132.256', 'C16.320.240.625', 'C19.297.155', 'C19.874.482.281'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery. | BACKGROUND: Phosphoinositide lipid kinases (PIKs) generate specific phosphorylated variants of phosatidylinositols (PtdIns) that are critical for second messenger signaling and cellular membrane remodeling. Mammals have 19 PIK isoforms spread across three major families: the PtIns 3-kinases (PI3Ks), PtdIns 4-kinases (P... | ['1-Phosphatidylinositol 4-Kinase', 'Animals', 'Drug Discovery', 'Eukaryota', 'Evolution, Molecular', 'Genomics', 'Humans', 'Molecular Sequence Data', 'Multigene Family', 'Phylogeny', 'Second Messenger Systems', 'Signal Transduction'] | 21,208,444 | [['D08.811.913.696.620.550'], ['B01.050'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['B01'], ['G05.045.250', 'G16.075.250'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['G05.697', 'G16.075.605', 'L01.10... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Effect of GnRH analogues pre-treatment on myomectomy outcomes in reproductive age women]. | OBJECTIVE: To evaluate the role of three-monthly pre-treatment with gonadothropin releasing hormone (GnRH) analogues prior to myomectomy for women in comparison with control group of patients with no application. Analysis is focused on peroperative and postoperative results of surgery treatment for women with clinicall... | ['Adult', 'Antineoplastic Agents, Hormonal', 'Blood Loss, Surgical', 'Female', 'Gonadotropin-Releasing Hormone', 'Goserelin', 'Humans', 'Laparoscopy', 'Laparotomy', 'Leiomyoma', 'Length of Stay', 'Neoadjuvant Therapy', 'Postoperative Hemorrhage', 'Preoperative Care', 'Uterine Neoplasms'] | 22,702,067 | [['M01.060.116'], ['D27.505.954.248.169'], ['C23.550.414.300', 'C23.550.505.300'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['D06.472.699.327.740.320.340', 'D12.644.400.400.740.320.340', 'D12.644.456.460.315', 'D12.644.548.365.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Infrarenal aortic rupture in association with a contiguous polymicrobial intraabdominal abscess including Eikenella corrodens. | Aortic rupture in association with a contiguous intraabdominal abscess is rare. We report an unusual case of aortic rupture in association with a polymicrobial abscess and review the related literature. Cultures grew Eikenella corrodens, a rare intraabdominal pathogen, as well as betahemolytic streptococcus and S. viri... | ['Abdominal Abscess', 'Aorta, Abdominal', 'Aortic Rupture', 'Aortitis', 'Bacterial Infections', 'Blood Vessel Prosthesis Implantation', 'Eikenella corrodens', 'Gram-Negative Bacterial Infections', 'Humans', 'Male', 'Middle Aged', 'Streptococcal Infections', 'Tomography, X-Ray Computed'] | 10,943,795 | [['C01.830.025.020'], ['A07.015.114.056.205'], ['C14.907.055.185.125', 'C14.907.055.239.175', 'C14.907.109.139.175', 'C26.761.125'], ['C14.907.109.320', 'C14.907.940.080'], ['C01.150.252'], ['E04.100.814.868.500', 'E04.650.200'], ['B03.440.450.400.275', 'B03.660.075.525.170.100'], ['C01.150.252.400'], ['B01.050.150.900... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells. | Rapid growth of BHK cells in methioninedeficient medium required supplementation with homocysteine, B(12), and over 40-fold greater levels of folic acid than growth in methionine-supplemented medium. The activity of the B(12)-dependent 5-methyltetrahydrofolate: homocysteine methyltransferase was studied in extracts of ... | ['Animals', 'Cells, Cultured', 'Cricetinae', 'Folic Acid', 'Homocysteine', 'Kidney', 'Mercaptoethanol', 'Methionine', 'Methyltransferases', 'Puromycin', 'Tetrahydrofolates', 'Vitamin B 12'] | 4,517,673 | [['B01.050'], ['A11.251'], ['B01.050.150.900.649.313.992.635.075.250'], ['D03.633.100.733.631.400'], ['D02.886.030.498', 'D12.125.166.498'], ['A05.810.453'], ['D02.033.375.534', 'D02.886.489.409'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.549', 'D12.125.166.676'], ['D08.811.913.555.500'], ['D02.241.223.200.3... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gas handling in the caecum of the horse. | Electromanometric recordings of caecal pressures were made in chronically cannulated ponies. Endoscopy allowed direct observation of the caecal base and cupola while recording intracaecal pressures and enabled a functional interpretation of caecal pressure profiles. Using gas-tight seals, the caecal gas cap baseline pr... | ['Animals', 'Cecum', 'Eating', 'Electrophysiology', 'Endoscopy', 'Female', 'Gases', 'Gastrointestinal Motility', 'Horses', 'Insufflation', 'Manometry', 'Nitrogen', 'Pressure', 'Reference Values'] | 9,639,349 | [['B01.050'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['G07.203.650.283', 'G10.261.330'], ['H01.158.344.528', 'H01.158.782.236'], ['E01.370.388.250', 'E04.502.250'], ['D01.362'], ['G10.261.360'], ['B01.050.150.900.649.313.984.235.472'], ['E01.370.450', 'E02.583'], ['E05.559'], ['D01.268.604', 'D01.362.625'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Factor analysis of dynamic structures (FADS) in the diagnosis of renal disease. | Factor analysis of dynamic structures (FADS) has been used in the interpretation of dynamic scintigraphic studies since the technique was described by Bazin et al. (1980). This study was designed to analyse to what extent, if any, does physiological factor analysis of dynamic renal data really help the clinician and by... | ['Humans', 'Kidney Diseases', 'Organotechnetium Compounds', 'Pentetic Acid', 'Radioisotope Renography', 'Statistics as Topic', 'Technetium Tc 99m Pentetate'] | 2,689,179 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['D02.691.825'], ['D02.092.782.590', 'D02.241.081.018.639'], ['E01.370.350.710.715.700', 'E01.370.384.730.715.700', 'E01.370.390.400.700'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['D02.092.782.590.883', ... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A comparison of the metabolic effects of continuous hypothermic perfusion or oxygenated persufflation during hypothermic storage of rat liver. | The metabolic consequences of supplying oxygen by two different modes were investigated. The effects of hypothermic liver preservation after cold hypoxic flush (Group I), oxygenated vascular persufflation (Group II), and continuous oxygenated perfusion (Group III) were compared. Adenine nucleotides were measured to ass... | ['Adenine Nucleotides', 'Amino Acids', 'Animals', 'Cryopreservation', 'Energy Metabolism', 'Fumarates', 'Glucose', 'In Vitro Techniques', 'Ketone Bodies', 'Kinetics', 'Lactic Acid', 'Liver', 'Magnetic Resonance Spectroscopy', 'Male', 'Mitochondria, Liver', 'Oxidation-Reduction', 'Oxygen', 'Perfusion', 'Rats', 'Rats, Sp... | 11,888,217 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['D12.125'], ['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['G03.295'], ['D02.241.081.337.302'], ['D09.947.875.359.448'], ['E05.481'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cooled radiofrequency ablation of the genicular nerves for chronic pain due to osteoarthritis of the knee: a cost-effectiveness analysis based on trial data. | BACKGROUND: For patients with painful knee osteoarthritis, long-term symptomatic relief may improve quality of life. Cooled radiofrequency ablation (CRFA) has demonstrated significant improvements in pain, physical function and health-related quality of life compared with conservative therapy with intra-articular stero... | ['Arthralgia', 'Chronic Pain', 'Cost-Benefit Analysis', 'Cross-Over Studies', 'Denervation', 'Female', 'Glucocorticoids', 'Health Care Costs', 'Humans', 'Hypothermia, Induced', 'Injections, Intra-Articular', 'Knee Joint', 'Male', 'Medicare', 'Nerve Block', 'Osteoarthritis, Knee', 'Prospective Studies', 'Quality-Adjuste... | 31,238,925 | [['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['C23.888.592.612.274'], ['N03.219.151.125'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E04.525.210'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.6... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Detection of antigens in urine of mice and humans infected with Borrelia burgdorferi, etiologic agent of Lyme disease. | Lyme disease is a seasonal tick-borne malady which has worldwide distribution. Early and accurate diagnosis of Lyme disease is essential for successful antibiotic therapy. Symptoms are too vague to make an early diagnosis based on conventional criteria. We report the detection of antigens of Borrelia burgdorferi, causa... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Bacterial', 'Blotting, Western', 'Borrelia', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Lyme Disease', 'Mice'] | 2,913,036 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.161'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B03.440.425.410.711.193', 'B03.851.595.193'], ['E05.478.566.350.170', 'E05.478.566.380.360'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unclassified ovarian gonadal stromal tumors. A clinicopathologic study of 32 cases. | Approximately 10% of gonadal stromal (sex cord-stromal) tumors of the ovary are difficult to classify. In most of these cases, the differential diagnosis is between granulosa and Sertoli-Leydig types. We studied 32 such neoplasms. The tumors were divided into two groups: Group 1 consisted of tumors with a predominance ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Female', 'Granulosa Cell Tumor', 'Humans', 'Middle Aged', 'Ovarian Neoplasms', 'Prognosis', 'Retrospective Studies', 'Sertoli-Leydig Cell Tumor', 'Survival Rate'] | 8,651,349 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['C04.557.475.750.656', 'C04.588.322.455.398', 'C13.351.500.056.630.705.398', 'C13.351.937.418.685.398', 'C19.344.410.398', 'C19.391.630.705.398'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prevalence of renal involvement in Schistosoma japonicum infection. | 244 outpatients and 100 hospitalized patients with confirmed Schistosoma japonicum infection were prospectively surveyed for the presence of nephropathy. There was no association between schistosomiasis and renal disease in the outpatient group. Three hospitalized patients had evidence of significant nephropathy, but t... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Kidney Diseases', 'Male', 'Middle Aged', 'Prospective Studies', 'Schistosomiasis japonica'] | 3,113,006 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C01.610.335.865.859.521', 'C01.920.922.521']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inactivation of single-celled Ascaris suum eggs by low-pressure UV radiation. | Intact and decorticated single-celled Ascaris suum eggs were exposed to UV radiation from low-pressure, germicidal lamps at fluences (doses) ranging from 0 to 8,000 J/m2 for intact eggs and from 0 to 500 J/m2 for decorticated eggs. With a UV fluence of 500 J/m2, 0.44-+/-0.20-log inactivation (mean+/-95% confidence inte... | ['Animals', 'Ascaris suum', 'Disinfection', 'Dose-Response Relationship, Radiation', 'Ovum', 'Parasite Egg Count', 'Radiography', 'Ultraviolet Rays', 'Water'] | 16,517,669 | [['B01.050'], ['B01.050.500.500.294.400.500.100.108.700'], ['N06.850.780.200.450.850.375'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['E01.370.225.932.600', 'E05.200.932.600'], ['E01.370.350.700'], ['G01.358.50... | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Significance of plasma fibrinogen in coronary arterial disease: marker or causative risk factor for arterial thrombosis? | The relationship between fibrinogen and severity of disease was measured in patients with coronary arterial disease (n = 301) prior to surgical coronary revascularisation. Platelet reactivity (shear-induced haemostasis) was measured from non-anticoagulated blood, in vitro. Coagulation was assessed by the clotting time ... | ['Blood Coagulation', 'Coronary Disease', 'Coronary Thrombosis', 'Female', 'Fibrinogen', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation', 'Risk Factors'] | 1,563,880 | [['G09.188.390.150'], ['C14.280.647.250', 'C14.907.585.250'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G09.188.370.687', 'G09.188.390.60... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-êB signaling in LPS-induced PC3 cells. | INTRODUCTION: Matrix metalloproteinase enzymes (MMPs) play important role in inflammation, malignant cell proliferation, invasion and angiogenesis by mediating extracellular matrix degradation. Doxycycline, a synthetic tetracycline, behaves as a MMP inhibitor at a subantimicrobial dose and inhibits tumor cell prolifera... | ['Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Down-Regulation', 'Doxycycline', 'Enzyme Activation', 'Gelatinases', 'Humans', 'I-kappa B Kinase', 'Immunohistochemistry', 'Lipopolysaccharides', 'Male', 'Matrix Metalloproteinases', 'NF-KappaB Inhibitor alpha', 'NF-kappa B', 'Neoplasm Invasiveness', 'Prostat... | 27,966,209 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['G02.111.263', 'G03.328'], ['D08.811.277.656.300.480.252', 'D08.811.277.656.675.374.252'], ['B0... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Antinociception induced by local injections of carbachol into the nucleus raphe magnus in rats: alteration by intrathecal injection of monoaminergic antagonists. | Electrical stimulation of neurons located in the nucleus raphe magnus (NRM) produces antinociception which appears to result from inhibition of spinothalamic tract neurons located in the spinal cord dorsal horn. Iontophoretic application of acetylcholine also activates NRM neurons and microinjection of cholinergic agon... | ['Animals', 'Brain Mapping', 'Carbachol', 'Efferent Pathways', 'Norepinephrine', 'Pain', 'Raphe Nuclei', 'Rats', 'Rats, Inbred Strains', 'Serotonin', 'Spinal Cord'] | 3,708,347 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['A08.612.380'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.830'], ['C23.888.592.612', 'F02.830.816.444'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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