Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile. | Optimization of HTS hit 1 for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study. Among them, derivative 4i inhibited food intake induced by the NPY Y5 selective agonist, and chronic oral ... | ['Administration, Oral', 'Animals', 'Anti-Obesity Agents', 'Benzimidazoles', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Half-Life', 'Mice', 'Obesity', 'Rats', 'Receptors, Neuropeptide Y', 'Structure-Activity Relationship', 'Sulfones', 'Weight Gain'] | 23,206,862 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.203'], ['D03.633.100.103'], ['D27.505.389.500', 'D27.505.519.389.335'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G01.910.405'], ['B01.050.150.900.649.313.992.635.505.500'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.12... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hygiene habits and carriers in families with a child who has had typhoid fever. | The relationship between asymptomatic shedding of bacterial enteropathogens and the hygiene habits of families who have had a child with typhoid fever (TF) are investigated. The sample was made up of 80 families: 40 families in which one child had had TF (Group A) and 40 in which no children or either of the parents ha... | ['Adolescent', 'Adult', 'Carrier State', 'Child', 'Child, Preschool', 'Chile', 'Enterobacteriaceae', 'Family', 'Feces', 'Habits', 'Humans', 'Hygiene', 'Infant', 'Infant, Newborn', 'Socioeconomic Factors', 'Typhoid Fever'] | 1,307,431 | [['M01.060.057'], ['M01.060.116'], ['N06.850.520.169'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.107.757.235'], ['B03.440.450.425', 'B03.660.250.150'], ['F01.829.263', 'I01.880.853.150'], ['A12.459'], ['F01.145.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06.850.670'], ['M01.060.703'], ['M01... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. | We have previously reported that a neuroprotective substance, serofendic acid, was purified and isolated from fetal calf serum. Here, we investigated the effect of serofendic acid on glutamate-induced apoptosis using rat primary cultures of cortical neurons. Exposure of the cortical cultures to relatively low concentra... | ['Amino Acid Chloromethyl Ketones', 'Animals', 'Apoptosis', 'Calcium', 'Caspase 3', 'Caspase 7', 'Caspase 8', 'Caspase Inhibitors', 'Cattle', 'Cells, Cultured', 'Cerebral Cortex', 'Diterpenes', 'Dose-Response Relationship, Drug', 'Enzyme Activation', 'Fetal Blood', 'Fetus', 'Glutamates', 'Humans', 'Intracellular Fluid'... | 16,806,165 | [['D12.125.065'], ['B01.050'], ['G04.146.954.035'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.350.700', 'D08.811.277.656.300.200.126.35... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trauma raises questions. | In an era of shrinking federal resources and a growing indigent patient population, how can a major hospital retain a successful trauma center that doesn't drain its financial base? Jeptha W. Dalston, Ph.D., president of Houston's Hermann Hospital, a 516-bed institution that revamped its trauma center, and, in the proc... | ['Community-Institutional Relations', 'Financial Management, Hospital', 'Hospital Bed Capacity, 500 and over', 'Humans', 'Medicaid', 'Texas', 'Trauma Centers', 'United States'] | 10,107,813 | [['N04.452.822.210'], ['N02.278.216.500.875', 'N03.219.463.280', 'N04.452.442.452.180'], ['N02.278.306.472.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['Z01.107.567.875.760.750'], ['N02.278.216.500.968.336.500', 'N02.421.297.195.480', 'N04.452.442.452.422.... | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor. | Rhizobium leguminosarum is a soil bacterium that infects root hairs and induces the formation of nitrogen-fixing nodules on leguminous plants. Light, oxygen, and voltage (LOV)-domain proteins are blue-light receptors found in higher plants and many algae, fungi, and bacteria. The genome of R. leguminosarum bv. viciae 3... | ['Amino Acid Sequence', 'Bacterial Adhesion', 'Base Sequence', 'Biofilms', 'Blotting, Western', 'Flagella', 'Gentian Violet', 'Histidine Kinase', 'Light', 'Microscopy, Electron, Scanning', 'Molecular Sequence Data', 'Peas', 'Photoreceptors, Microbial', 'Plant Root Nodulation', 'Polysaccharides, Bacterial', 'Protein Kin... | 22,773,814 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G06.099.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A20.593', 'G06.120'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.284.180.290'], ['D02.092.146.400'], ['D08.811.913.696.620.682.424'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Detection of Chlamydia trachomatis in formalin-fixed endometrial tissue. | Formalin-fixed tissue biopsies from 29 women with the histological diagnosis of severe endometritis were examined for chlamydial antigen by fluorescein-conjugated monoclonal chlamydial antibodies (SYVA) technique; 15 (52%) were positive. In nine patients also samples for isolation of Chlamydia trachomatis by cell-cultu... | ['Adolescent', 'Adult', 'Antigens, Bacterial', 'Biopsy', 'Chlamydia Infections', 'Chlamydia trachomatis', 'Endometrium', 'Female', 'Formaldehyde', 'Humans', 'Middle Aged', 'Tissue Preservation'] | 2,365,120 | [['M01.060.057'], ['M01.060.116'], ['D23.050.161'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Solubilizing effects caused by alkyl pyridinium surfactants in phosphatidylcholine liposomes. | The solubilization of neutral and electrically charged liposomes by a series of alkyl pyridinium surfactants (alkyl chain lengths C10-C14) was investigated. Solubilization was detected as a decrease in static light-scattering of liposome suspensions. Two parameters were regarded as corresponding to the effective surfac... | ['Amines', 'Light', 'Liposomes', 'Phosphatidic Acids', 'Phosphatidylcholines', 'Pyridinium Compounds', 'Scattering, Radiation', 'Solubility', 'Surface-Active Agents'] | 7,586,094 | [['D02.092'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D10.570.755.375.760'], ['D10.570.755.375.760.400.800'], ['D03.383.725.762'], ['E05.196.822', 'G01.867'], ['G02.805'], ['D27.720.877']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Why do we still call them "paradoxes"? | The fact that therapists label some events "paradoxical" may suggest that our current beliefs or theories are limited in their ability to adequately account for those phenomena. It is argued that our underlying belief in objectivity surrounds therapeutic "paradoxes" with a persistently paradoxical aura, and leads to co... | ['Communication', 'Environment', 'Homeostasis', 'Humans', 'Logic', 'Mental Disorders', 'Problem Solving', 'Psychological Theory', 'Psychotherapy', 'Reinforcement, Psychology', 'Selection, Genetic', 'Terminology as Topic'] | 3,732,503 | [['F01.145.209', 'L01.143'], ['G16.500.275', 'N06.230'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.752.448'], ['F03'], ['F02.463.425.725', 'F02.463.785.810'], ['F02.739'], ['F04.754'], ['F02.463.425.770'], ['G05.783'], ['L01.559.598.400']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Influence of surgical therapy on serum values of alpha 1-antitrypsin in patients with head and neck tumors. | INTRODUCTION AND AIM: The aim of this study was to quantitatively evaluate serum concentration of alpha 1-antitrypsin (A1AT) in patients undergoing surgery of head and neck malignant tumors.PATIENTS AND METHODS: Fifty patients undergoing surgery because of head and neck tumors in the years 2007-2008 were analyzed. Seri... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Carcinoma, Squamous Cell', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Laryngeal Neoplasms', 'Male', 'Middle Aged', 'alpha 1-Antitrypsin'] | 21,585,184 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.481', 'C08.360.369', 'C08.785.481', 'C09.400.369', 'C09.647.481'], ['M01.060.116.630'], ['D12.644.861.035',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Definitive hypofractionated radiotherapy for early glottic carcinoma: experience of 55Gy in 20 fractions. | INTRODUCTION: A wide variety of fractionation schedules have been employed for the treatment of early glottic cancer. The aim is to report our 10-year experience of using hypofractionated radiotherapy with 55Gy in 20 fractions at 2.75Gy per fraction.METHODS: Patients treated between 2004 and 2013 with definitive radiot... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Dose Fractionation, Radiation', 'Female', 'Glottis', 'Humans', 'Kaplan-Meier Estimate', 'Laryngeal Neoplasms', 'Male', 'Middle Aged', 'Proportional Hazards Models', 'Radiotherapy', 'Retrospective Studies'] | 26,395,876 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.815.639.200'], ['A04.329.364'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['C04.588.443.665.481', 'C08.360.369', 'C0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity. | ROMK (Kir1.1) channels are important for K secretion and recycling in the collecting duct, connecting tubule and thick ascending limb of the mammalian nephron. We have identified a highly conserved Arg in the P loop of the channel near the selectivity filter that controls Rb/K selectivity. Mutation of this Arg to a Tyr... | ['Animals', 'Arginine', 'Conserved Sequence', 'Ion Channel Gating', 'Kinetics', 'Potassium', 'Potassium Channels, Inwardly Rectifying', 'Rats', 'Rubidium', 'Substrate Specificity'] | 20,458,182 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G02.111.570.580'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['G01.374.661', 'G02.111.490'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D12.776.157.530.400.600.450', 'D12.776.543.550.450.750.450', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation and characterization of freeze-dried 2-methoxyestradiol nanoparticle powders. | Poorly water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. In the present study, a nanoprecipitation-high-frequency ultrasonication technique was adapted to produce drug nanosuspensions. The formulation of 2-methoxy... | ['2-Methoxyestradiol', 'Calorimetry, Differential Scanning', 'Chemistry, Pharmaceutical', 'Estradiol', 'Freeze Drying', 'Microscopy, Electron, Scanning', 'Nanoparticles', 'Particle Size', 'Powders', 'Solubility', 'Suspensions', 'Ultrasonics', 'X-Ray Diffraction'] | 20,662,313 | [['D04.210.500.365.415.248.830', 'D06.472.334.851.437.500.750'], ['E05.196.131.310', 'E05.196.370.310'], ['H01.158.703.007', 'H01.181.466'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects of silkworm larvae powder containing manganese superoxide dismutase on immune activity of mice. | To study the function of silkworm larvae powder containing superoxide dismutase and potential practical development, we investigated the safety assessment and effects on immune activity of mice such as the growth of immunity-related organs, delayed-type hypersensitivity (DTH) and charcoal particle clearance ability. Th... | ['Animals', 'Bombyx', 'Immunity', 'Immunologic Factors', 'Larva', 'Male', 'Mice', 'Mice, Inbred ICR', 'Superoxide Dismutase'] | 17,605,091 | [['B01.050'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['G12.450'], ['D27.505.696.477'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['D08.811.682.881']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution of galanin and galanin transcript in the brain of a galanin-overexpressing transgenic mouse. | The distribution of galanin mRNA-expressing cells and galanin-immunoreactive (IR) cell bodies and processes was studied in the brain of mice overexpressing galanin under the PDGF-B promoter (GalOE mice) and of wild type (WT) mice, both in colchicine-treated and non-treated animals. In this abstract, we only describe th... | ['Animals', 'Becaplermin', 'Brain', 'Galanin', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Mice, Transgenic', 'Neurons', 'Organ Specificity', 'Platelet-Derived Growth Factor', 'Promoter Regions, Genetic', 'Proto-Oncogene Proteins c-sis', 'RNA, Messenger'] | 15,531,132 | [['B01.050'], ['D12.644.276.910.650.500', 'D12.776.260.690.500', 'D12.776.467.910.650.500', 'D23.529.910.650.500'], ['A08.186.211'], ['D12.644.400.250', 'D12.776.631.650.250'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorine-fluorine spin-spin coupling constants in aromatic compounds: correlations with the delocalization index and with the internuclear separation. | This paper describes a new empirical approach for the evaluation of fluorine-fluorine spin-spin coupling constants (J(FF)) in aromatic compounds. The correlations between J(FF) and the delocalization index calculated within the framework of the theory of atoms in molecules (AIM) and with the fluorine-fluorine internucl... | ['Fluorine', 'Molecular Structure', 'Organic Chemicals'] | 15,807,499 | [['D01.268.380.300'], ['G02.111.570', 'G02.466'], ['D02']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Insecticide resistance in German cockroaches (Blattella germanica) from hospitals and households in Taiwan. | Since a high percentage of cockroach infestation has been determined in hospitals in Kaohsiung, South Taiwan, insecticide resistances may have developed in the cockroach populations. To determine the resistances in cohorts of German cockroach (Blattella germanica) from hospitals and households to organophosphates, carb... | ['Animals', 'Biological Assay', 'Chlorpyrifos', 'Cockroaches', 'Hospitals', 'Housing', 'Insecticide Resistance', 'Insecticides', 'Lethal Dose 50', 'Propoxur', 'Pyrethrins', 'Taiwan'] | 16,025,812 | [['B01.050'], ['E05.091'], ['D02.705.400.625.100', 'D02.705.539.345.100', 'D02.886.300.692.100'], ['B01.050.500.131.617.140'], ['N02.278.421'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['G07.690.773.984.491'], ['D27.720.031.700.491', 'D27.888.723.491'], ['E05.940.402', 'G07.225.500'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
An unusual alkaline phosphatase isoenzyme in a patient with concomitant marked elevation of acid phosphatase without clinical evidence of prostatic carcinoma. | An 81-year-old male with congestive heart failure and prostatic hypertrophy was found to have markedly elevated serum acid phosphatase (EC 3.1.3.2) and moderately elevated serum alkaline phosphatase (EC 3.1.3.1). Alkaline phosphatase isoenzyme analysis was performed to determine the organ source of the enzyme. There wa... | ['Acid Phosphatase', 'Aged', 'Alkaline Phosphatase', 'Heart Failure', 'Homoarginine', 'Humans', 'Isoenzymes', 'Liver', 'Male', 'Phenylalanine', 'Prostatic Hyperplasia'] | 61,077 | [['D08.811.277.352.650.025'], ['M01.060.116.100'], ['D08.811.277.352.650.035'], ['C14.280.434'], ['D12.125.068.050.400', 'D12.125.095.104.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['A03.620'], ['D12.125.072.050.685', 'D12.125.142.666'], ['C12.294.565.500']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dietary cumulative acute risk assessment of organophosphorus, carbamates and pyrethroids insecticides for the Brazilian population. | Cumulative acute dietary risk assessments of organophosphorus (OPs), carbamates (CBs) and pyrethroids (PYs) were conducted for the Brazilian population. Residue data for 30786 samples of 30 foods were obtained from two national monitoring programs and one University laboratory, and consumption data from a national surv... | ['Adolescent', 'Adult', 'Brazil', 'Carbamates', 'Child', 'Dietary Exposure', 'Female', 'Humans', 'Insecticides', 'Male', 'Monte Carlo Method', 'Organophosphorus Compounds', 'Pesticide Residues', 'Pyrethrins', 'Risk Assessment', 'Young Adult'] | 29,274,435 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['D02.241.081.251'], ['M01.060.406'], ['N06.850.460.350.040'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.031.700.491', 'D27.888.723.491'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['D02.705'], ['D27.720... | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Effects of repeated doses of caffeine on mood and performance of alert and fatigued volunteers. | Evidence for behavioural effects of caffeine is well documented in the literature. It is associated with increased subjective alertness, improved reaction time and enhanced encoding of new information. These effects are most prominent in low arousal situations. However, there is an ongoing debate as to whether such cha... | ['Adolescent', 'Adult', 'Affect', 'Arousal', 'Attention', 'Caffeine', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Humans', 'Male', 'Mental Fatigue', 'Pattern Recognition, Visual', 'Psychomotor Performance', 'Reaction Time'] | 16,272,184 | [['M01.060.057'], ['M01.060.116'], ['F01.470.047'], ['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['B01.050.150.900.64... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Protein kinase C activators mimic the M2-muscarinic receptor-mediated effects on the action potential in isolated sympathetic neurons of rabbits. | Protein kinase C activators 1,2-oleoylacetylglycerol (OAG, 0.5-50 microM), a synthetic diacylglycerol analog, and phorbol-12,13-dibutyrate (Pb(Bu)2, 0.016-1.6 microM) depressed the calcium (Ca)-dependent components of action potentials in isolated superior cervical ganglion cells of rabbits. Similar depressions were el... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'Action Potentials', 'Adrenergic Fibers', 'Animals', 'Calcium', 'Diglycerides', 'Glycerides', 'In Vitro Techniques', 'Isoquinolines', 'Phorbol 12,13-Dibutyrate', 'Phorbol Esters', 'Piperazines', 'Protein Kinase C', 'Rabbits', 'Receptors, Muscarinic', 'Tetrodotoxin'] | 3,163,415 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['A08.675.100.500', 'A08.675.542.075', 'A11.671.501.075'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D10.351.303'], ['D10.351'], ['E05.481'], ['D03.633.100.531'], ['D02.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A model of continuous quality improvement for health service organisations. | Continuous Quality Improvement (or Total Quality Management) is an approach to management originally used in manufacturing and now being applied in the health services. This article describes a model of Continuous Quality Improvement which has been used in NSW public and private hospitals. The model consists of Ten Key... | ['Appointments and Schedules', 'Data Collection', 'Decision Making, Organizational', 'Hospital Administration', 'Hospitals, Private', 'Hospitals, Public', 'Management Quality Circles', 'Models, Theoretical', 'New South Wales', 'Planning Techniques', 'Quality Assurance, Health Care', 'Systems Analysis'] | 10,117,452 | [['N04.452.095'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['N04.452.190'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['N02.278.421.481'], ['N02.278.421.510'], ['N04.452.677.420'], ['E05.599'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['N04.452.718'], ['N04.761.700', 'N05.700'],... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Separation of linoleic acid oxidation products by micellar electrokinetic capillary chromatography and nonaqueous capillary electrophoresis. | In this work the suitability of micellar electrokinetic capillary chromatography (MEKC) and nonaqueous capillary electrophoresis (CE) to the analysis of the primary oxidation products of linoleic acid was studied with uncoated fused-silica capillaries. The primary autoxidation products of linoleic acid are the four hyd... | ['Chromatography, Micellar Electrokinetic Capillary', 'Electrophoresis, Capillary', 'Linoleic Acid', 'Oxidation-Reduction'] | 10,065,966 | [['E05.196.181.500'], ['E05.196.401.190', 'E05.301.300.190'], ['D10.251.355.310.515.500', 'D10.251.355.343.500.500'], ['G02.700', 'G03.295.531']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Teratogenic effects of mild heat stress during mouse embryogenesis: effect of Trp53. | Hyperthermia can be teratogenic in fetal mice exposed during organogenesis, an effect considered to be due to heat-induced apoptosis of cells in the developing organs. We exposed pregnant mice carrying Trp53(+/+), Trp53(+/-) and Trp53(-/-) fetuses to mild whole-body hyperthermia that raised their core temperature to 40... | ['Animals', 'Embryonic and Fetal Development', 'Female', 'Fetal Death', 'Hot Temperature', 'Mice', 'Pregnancy', 'Tail', 'Tumor Suppressor Protein p53'] | 12,236,811 | [['B01.050'], ['G07.345.500.325', 'G08.686.784.170'], ['C13.703.223', 'C23.550.260.585'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['G08.686.784.769'], ['A13.895'], ['D12.776.157.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Polymorphism of codon25 in signal peptide region of transforming growth factor beta 1 and its association with chronic hepatitis C virus infection]. | OBJECTIVE: To investigate the possible relationship between polymorphism of codon25 in signal peptide region of transforming growth factor beta 1 (TGFb1) and hepatitis C virus (HCV) infection susceptibility.METHODS: Genotypes of TGFb1 of 191 subjects (85 HCV infected patients and 106 healthy controls) were studied. Gen... | ['Adult', 'Blood Donors', 'Case-Control Studies', 'Female', 'Genotype', 'Hepatitis C, Chronic', 'Humans', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Transforming Growth Factor beta1'] | 18,752,744 | [['M01.060.116'], ['M01.898.313'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.380'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Psychopathology of protracted endogenous depressions]. | A clinico-psychopathological study of 85 patients with protracted endogenous depressions permitted to distinguish 7 main syndromological types: melancholic, adynamic, dysphoric, anesthetical, anxious, cenestho-hypochondriacal and a complex type of depressive disorders with hallucinatory, delusional and catatonic distur... | ['Adult', 'Aged', 'Anxiety', 'Catatonia', 'Delusions', 'Depression', 'Diagnosis, Differential', 'Female', 'Hallucinations', 'Humans', 'Male', 'Middle Aged', 'Personality', 'Sensation', 'Syndrome'] | 525,121 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Substituted pyrimidines as cannabinoid CB1 receptor ligands. | Cannabinoid CB1 receptors have been the avenue of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and obesity-related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed and efficiently prepared a series... | ['Animals', 'Anti-Obesity Agents', 'Ligands', 'Pyrimidines', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Cannabinoid, CB1'] | 19,596,576 | [['B01.050'], ['D27.505.954.203'], ['D27.720.470.480'], ['D03.383.742'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.695.125.100']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Biological examination in hyperlipemia]. | The authors review the various methods of investigation useful in the classification of hyperlipoproteinaemias. Estimation of cholesterol and triglycerides remain the most important elements but do not suffice alone to reach a conclusion and measurement of phospholipids would seem to be a useful addition. Electrophores... | ['Cholesterol', 'Electrophoresis', 'Humans', 'Hyperlipidemias', 'Lipids', 'Lipoproteins, HDL', 'Lipoproteins, LDL', 'Lipoproteins, VLDL', 'Phospholipids', 'Triglycerides', 'Ultracentrifugation'] | 168,554 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E05.196.401', 'E05.301.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500'], ['D10'], ['D10.532.432', 'D12.776.521.479'], ['D10.532.515', 'D12.776.521.550'], ['D10.532.599', 'D12.776.521.622'], ['D10.570.755'], ['D1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatial and temporal variation in Anguillicola crassus counts: results of a 4 year survey of eels in Mediterranean lagoons. | We present the results of a survey of anguillicolosis in the Rh6ne River delta. From January 1997 to December 2000, a total of 13,319 eels (Anguilla anguilla from elver to silver phase) were examined, in which we found 22,227 swimbladder nematodes (Anguillicola crassus adults and pre-adults). A generalised linear model... | ['Age Factors', 'Air Sacs', 'Anguilla', 'Animals', 'Body Constitution', 'Data Collection', 'Fish Diseases', 'France', 'Geography', 'Host-Parasite Interactions', 'Nematode Infections', 'Population Dynamics', 'Prevalence', 'Seasons'] | 12,219,974 | [['N05.715.350.075', 'N06.850.490.250'], ['A13.048'], ['B01.050.150.900.493.338.282'], ['B01.050'], ['E01.370.600.115', 'G07.100'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['C22.362'], ['Z01.542.286'], ['H01.277.500'], ['G16.527.200.400'], ['C01.610.335.508'], ['I01.240.600', 'N01.224.625'... | ['Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats. | We have recently reported that PEGylated liposomes (PL) are cleared rapidly from the blood circulation when they are administered twice in the same rat at certain intervals, even if the liposomes are sterically stabilized by a surface modification with PEG (referred to as the accelerated blood clearance (ABC) phenomeno... | ['Animals', 'Injections, Intravenous', 'Liposomes', 'Liver', 'Male', 'Metabolic Clearance Rate', 'Particle Size', 'Phospholipids', 'Polyethylene Glycols', 'Rats', 'Rats, Wistar', 'Spleen', 'Surface Properties'] | 15,866,337 | [['B01.050'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A03.620'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['G02.712'], ['D10.570.755'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Melatonin administration to blind people: phase advances and entrainment. | The purpose of this study was to test the phase-shifting and entraining effects of melatonin in human subjects. Five totally blind men were found in a previous study to have free-running endogenous melatonin rhythms. Their rhythms were remarkably stable, so that any deviation from the predicted phase was readily detect... | ['Adult', 'Blindness', 'Circadian Rhythm', 'Double-Blind Method', 'Humans', 'Hydrocortisone', 'Male', 'Melatonin', 'Sleep Wake Disorders'] | 1,773,095 | [['M01.060.116'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['G07.180.562.190'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Time-lapse, photoactivation, and photobleaching imaging of nucleolar assembly after mitosis. | Nucleolus assembly starts in telophase with the benefit of building blocks passing through mitosis and lasts until cytokinesis generating the two independent interphasic cells. Several approaches make it possible to follow the dynamics of fluorescent molecules in live cells. Here, three complementary approaches are des... | ['Cell Line, Tumor', 'Cell Nucleolus', 'Chromosomal Proteins, Non-Histone', 'Fluorescence Recovery After Photobleaching', 'Green Fluorescent Proteins', 'HeLa Cells', 'Humans', 'Mitosis', 'Nuclear Proteins', 'Nucleolus Organizer Region', 'Time-Lapse Imaging'] | 23,980,017 | [['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106.279.345.175'], ['D12.776.660.235', 'D12.776.664.235'], ['E05.196.712.516.600.393'], ['D12.776.532.265'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G04.144.220.220.781', 'G05.113.220.781'], ... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Control of fructose 2,6-bisphosphate levels in rat macrophages by glucose and phorbol ester. | The presence of fructose 2,6-bisphosphate (Fru 2,6-P2) in elicited peritoneal macrophages of rat was examined. These cells possess an active phosphofructokinase-2 which is diminished by citrate and only slightly inhibited by glycerol 3-phosphate. Phosphofructokinase-1 submaximal activity was increased 26-fold by the ad... | ['Animals', 'Citrates', 'Citric Acid', 'Cyclic AMP', 'Dinoprost', 'Fructosediphosphates', 'Glucose', 'Glycogen', 'Hexosediphosphates', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lactates', 'Lactic Acid', 'Macrophages', 'Male', 'Phenylisopropyladenosine', 'Phosphofructokinase-1', 'Rats', 'Rats, Inbred Strains', 'Tetrade... | 2,546,818 | [['B01.050'], ['D02.241.081.901.434'], ['D02.241.081.901.434.249'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D10.251.355.255.550.400.200', 'D23.469.050.175.725.400.200'], ['D09.894.417.313.300', 'D09.894.417.592.300'], ['D09.947.875.359.448'], ['D05.750.078.562... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cognitive structure of occupational risks represented by a perceptual map. | The main focus of risk management is technical and rational analysis about the operational risks and by those imposed by the occupational environment. In this work one seeks to contribute to the risk perception study and to better comprehend how a group of occupational safety students assesses a set of activities and e... | ['Humans', 'Occupational Exposure', 'Occupational Health', 'Perception', 'Psychometrics', 'Risk Assessment', 'Students', 'Surveys and Questionnaires'] | 22,317,203 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.600'], ['N01.400.525'], ['F02.463.593'], ['F04.711.780'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['M01.848'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.... | ['Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Three cases of choriocarcinoma (author's transl). | Report on three cases of choriocarcinoma which showed interesting features. In the first case a living male infant was delivered two years following chemotherapy for choriocarcinoma and the infant showed no chromosomal abnormalities. In the second case a choriocarcinoma developed three years following a post-partum tub... | ['Adult', 'Choriocarcinoma', 'Female', 'Humans', 'Infant, Newborn', 'Pregnancy', 'Uterine Neoplasms'] | 640,365 | [['M01.060.116'], ['C04.557.465.955.207', 'C04.557.470.200.025.455', 'C04.850.908.208', 'C13.703.720.949.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hemoglobin A1c Levels Are Slightly but Significantly Lower in Normoglycemic Subjects With the Hemoglobin E Phenotype. | Hb mutations can alter the structure, behavior, stability, or quantity of the globin chain produced. Some Hb variants shorten the erythrocyte life span, resulting in physiologically lower hemoglobin A1c (HbA1c) levels. The hemoglobin E (HbE) phenotype involves a single-nucleotide polymorphism that reduces â-globin chai... | ['Blood Glucose', 'Case-Control Studies', 'Chromatography, High Pressure Liquid', 'Creatinine', 'Cross-Sectional Studies', 'Glycated Hemoglobin A', 'Hemoglobin A', 'Hemoglobin E', 'Humans', 'Immunoassay', 'Logistic Models', 'Phenotype'] | 30,430,785 | [['D09.947.875.359.448.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.196.181.400.300'], ['D03.383.129.308.207'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status. | The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and epigenetic features of... | ['Brain Neoplasms', 'CpG Islands', 'DNA Methylation', 'DNA Modification Methylases', 'DNA Repair Enzymes', 'Data Mining', 'Gene Silencing', 'Glioblastoma', 'High-Throughput Screening Assays', 'Humans', 'Logistic Models', 'Models, Statistical', 'Neoplasm Grading', 'Oligonucleotide Array Sequence Analysis', 'Phenotype', ... | 22,810,491 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D08.811.150.240', 'D08.811.913.555.500.350'], ['D08.811.074'], ['L01.313.500.750.280.199', 'L01.470.625'], ['... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Avian paramyxovirus type I infection in pigeons: clinical observations. | An outbreak of a neurological disease in pigeons caused by avian paramyxovirus type I occurred in the New York metropolitan area in 1984. It was characterized clinically by head tremors, paresis of the wings and legs, ataxia, torticollis, and loose droppings. Clinical pathologic evaluation revealed anemia and elevated ... | ['Animals', 'Blood Glucose', 'Blood Proteins', 'Columbidae', 'Hematocrit', 'L-Lactate Dehydrogenase', 'Leukocyte Count', 'Nervous System Diseases', 'New York City', 'Respirovirus Infections', 'Uric Acid'] | 3,833,225 | [['B01.050'], ['D09.947.875.359.448.500'], ['D12.776.124'], ['B01.050.150.900.248.165.150'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Effect of multi-lumen perfusion line on catheter-related bacteremia in premature infants: study protocol for a cluster-randomized crossover trial. | BACKGROUND: Catheter-related bacteremia (CRB) is the most frequent nosocomial infection in neonatal intensive care unit (NICU) patients, especially in very low-birth-weight infants. Administration of injectable drugs in premature newborn infants has many particularities and several types of infusion incidents have been... | ['Bacteremia', 'Catheter-Related Infections', 'Catheterization, Central Venous', 'Catheters, Indwelling', 'Central Venous Catheters', 'Cross Infection', 'Cross-Over Studies', 'Equipment Design', 'Female', 'Gestational Age', 'Humans', 'Infant, Extremely Premature', 'Infant, Newborn', 'Infusions, Intravenous', 'Intensive... | 30,744,679 | [['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['C01.195'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['E07.132.500'], ['E07.132.750.500'], ['C01.248', 'C23.550.291.875.500'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.320'], ['G07.345.500.3... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nutritional Status of Elderly Patients after Coronary Artery Bypass Surgery. | Surgical trauma can result in immobilization of biological material, degradation of muscle proteins, synthesis of acute-phase proteins in the liver, occurrence of catabolism phase and anabolism simultaneously, and as a consequence weight loss and nutritional deficiencies. The aim of this study was to assess the nutriti... | ['Activities of Daily Living', 'Aged', 'Body Mass Index', 'Body Weight', 'Coronary Artery Bypass', 'Geriatric Assessment', 'Humans', 'Male', 'Malnutrition', 'Middle Aged', 'Myocardial Ischemia', 'Nutrition Assessment', 'Nutritional Status', 'Surveys and Questionnaires', 'Weight Loss'] | 30,650,558 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E04.100.376... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin. | A set of phosphonic acid derivatives (1-4) of pyridoxal 5'-phosphate (PLP) was synthesized and characterized biochemically using purified murine pyridoxal phosphatase (PDXP), also known as chronophin. The most promising compound 1 displayed primarily competitive PDXP inhibitory activity with an IC50 value of 79ìM, whic... | ['Animals', 'Crystallography, X-Ray', 'Enzyme Inhibitors', 'Hydrolysis', 'Mice', 'Molecular Docking Simulation', 'Phosphoprotein Phosphatases', 'Phosphoric Monoester Hydrolases', 'Pyridoxal Phosphate'] | 25,783,190 | [['B01.050'], ['E05.196.309.742.225'], ['D27.505.519.389'], ['G02.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595.249', 'L01.224.160.249'], ['D08.811.277.352.650.625'], ['D08.811.277.352.650'], ['D03.383.725.676.925.500.500', 'D08.211.740']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ring uncemented hip replacements. The results of revision. | Since 1964, 3573 uncemented Ring total hip replacements of all types have been performed; 194 (5.4%) have required revision for infection, loosening or breakage. Of these, 102 were available for review; 81 had satisfactory results five years after operation. These results are better than many of those reported after re... | ['Aged', 'Bone Cements', 'Female', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Joint Instability', 'Male', 'Methods', 'Middle Aged', 'Osteoarthritis', 'Postoperative Complications', 'Radiography', 'Reoperation'] | 3,584,187 | [['M01.060.116.100'], ['D05.750.716.822.300', 'D25.720.716.822.300', 'D27.720.102.158', 'J01.637.051.720.716.822.300'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.521'], ['E05.581'], ['M01.060.116.630'], ['C05.550.114.606', 'C05.799.613'], ['C23.550.767'], ['E01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. | The Sox-2 gene is expressed in embryonic stem (ES) cells and neural stem cells. Two transcription enhancer regions, Sox-2 regulatory region 1 (SRR1) and SRR2, were described previously based on their activities in ES cells. Here, we demonstrate that these regulatory regions also exert their activities in neural stem ce... | ['Animals', 'Brain', 'Cell Differentiation', 'Cell Line', 'DNA-Binding Proteins', 'Enhancer Elements, Genetic', 'Female', 'Gene Expression Regulation, Developmental', 'HMGB Proteins', 'Hematopoietic Stem Cells', 'Immunohistochemistry', 'Intermediate Filament Proteins', 'Mice', 'Mice, Inbred ICR', 'Multipotent Stem Cell... | 15,121,842 | [['B01.050'], ['A08.186.211'], ['G04.152'], ['A11.251.210'], ['D12.776.260'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['G05.308.310'], ['D12.776.260.356', 'D12.776.660.235.400.600', 'D12.776.664.235.400.600'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['E01.370.22... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Randomized controlled trial of different aspirin regimens for reduction of niacin-induced flushing. | PURPOSE: Results of a study to test the hypothesis that taking niacin simultaneously with different forms of aspirin would reduce the occurrence of niacin-induced flushing are reported.METHODS: Traditionally, taking enteral absorbed aspirin 30 minutes before a niacin dose has been shown to reduce flushing by 30-50% rel... | ['Adult', 'Anti-Inflammatory Agents, Non-Steroidal', 'Aspirin', 'Cross-Over Studies', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'Flushing', 'Humans', 'Male', 'Niacin', 'Vasodilator Agents'] | 28,432,049 | [['M01.060.116'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.455.426.559.389.657.410.595.176'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Oxygen and pulse oximetry in childhood pneumonia: a survey of healthcare providers in resource-limited settings. | Globally, pneumonia is the leading cause of death in children <5 years of age. Hypoxemia, a frequent complication of pneumonia, is a risk factor for death. To better understand the availability of oxygen and pulse oximetry, barriers to use and provider perceptions and practices regarding their role in childhood pneumon... | ['Africa', 'Asia', 'Child', 'Child, Preschool', 'Female', 'Health Care Surveys', 'Health Knowledge, Attitudes, Practice', 'Health Personnel', 'Humans', 'Hypoxia', 'Infant', 'Infant, Newborn', 'Oximetry', 'Oxygen Inhalation Therapy', 'Pneumonia', 'Risk Factors', 'South America'] | 22,170,511 | [['Z01.058'], ['Z01.252'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['F01.100.150.500', 'N05.300.150.410'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['M0... | ['Geographicals [Z]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[MR urography with the T2-weighted turbo-spin-echo sequence]. | Tumor-induced dilatation of the urinary tract is difficult to diagnose in the distal part of the ureter, including the stenosis, by ultrasound and X-ray. Often on account of renal insufficiency and allergy, i.v.-contrast media cannot be used. The present study should show the suitability of fast T2-weighted (turbo-) sp... | ['Adult', 'Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Endometrial Neoplasms', 'Female', 'Humans', 'Hydronephrosis', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Rectal Neoplasms', 'Ureter', 'Ureteral Neoplasms', 'Ureteral Obstruction', 'Urography',... | 7,495,896 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.307', 'C13.351.968.419.307'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.697.655', 'C23.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vivo (1) H MR spectroscopic imaging of aggressive prostate cancer: can we detect lactate? | PURPOSE: A semi-LASER sequence was optimized for in vivo lactate detection in the prostate.METHODS: The ethical committee waived the need for informed consent to measure 17 patients with high grade prostate cancer on a 3T system. A semi-LASER sequence was used with an echo time of 144 ms and optimized interpulse timing... | ['Aged', 'Aged, 80 and over', 'Algorithms', 'Biomarkers, Tumor', 'Computer Simulation', 'Humans', 'Lactic Acid', 'Magnetic Resonance Spectroscopy', 'Male', 'Models, Biological', 'Prostatic Neoplasms', 'Protons', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 23,475,759 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['D23.101.140'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459.450'], ['E05.196.867.519'], ['E05.599.395'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D01.248.497.300... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Expression of M-CSF and CSF-1R is correlated with histological grade in soft tissue tumors. | BACKGROUND: Macrophage colony stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and thereby stimulates the proliferation, differentiation and behaviour of monocytes, macrophages and their bone marrow progenitors. Previous studies have suggested that high expression of these markers is co... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antigens, CD', 'Antigens, Differentiation, Myelomonocytic', 'Female', 'Humans', 'Immunohistochemistry', 'Leiomyosarcoma', 'Macrophage Colony-Stimulating Factor', 'Male', 'Middle Aged', 'Receptor, Macrophage Colony-Stimulating Factor', 'Sarcoma', 'Soft Tissue Neoplas... | 19,846,920 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.900', 'D23.101.100.900'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Skin penetration of CoQ10 in the rat. | Skin penetration of coenzyme Q10 (CoQ10) was investigated after topical treatment in the rat. The drug was suspended in olive oil and administered at two different concentrations. Coenzyme levels were found to be directly related to the concentrations employed and the contact time. CoQ10 topical treatment might therefo... | ['Absorption', 'Administration, Topical', 'Animals', 'Coenzymes', 'Male', 'Osmolar Concentration', 'Rats', 'Rats, Inbred Strains', 'Skin', 'Time Factors', 'Ubiquinone'] | 3,182,185 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['E02.319.267.120'], ['B01.050'], ['D08.211'], ['G02.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['A17.815'], ['G01.910.857'], ['D02.806.250.900', 'D08.211.935']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diurnal variation of Quercus variabilis trunk diameter in response to environmental factors at south aspect of Taihang Mountains]. | By using Circumference Dendrometer 2 (DC2), this paper studied the diurnal variation of trunk diameter in Quercus variabilis plantation at the south aspect of Taihang Mountains. During seasonal drought, the diurnal variation of Q. variabilis trunk diameter was quite evident. The time of the diameter shrinkage followed ... | ['China', 'Ecosystem', 'Environment', 'Plant Stems', 'Plant Transpiration', 'Quercus'] | 23,189,691 | [['Z01.252.474.164'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275', 'N06.230'], ['A18.024.937'], ['G15.713'], ['B01.650.940.800.575.912.250.859.750.300.500']] | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro. | Adenosine has been proposed as a homeostatic "sleep factor" that promotes the transition from waking to sleep by affecting several sleep-wake regulatory systems. In the basal forebrain, adenosine accumulates during wakefulness and, when locally applied, suppresses neuronal activity and promotes sleep. However, the neur... | ['Acetylcholine', 'Action Potentials', 'Adenosine', 'Adenosine A1 Receptor Agonists', 'Adenosine A1 Receptor Antagonists', 'Animals', 'Cholinergic Fibers', 'Female', 'Male', 'Neural Inhibition', 'Neurons', 'Organ Culture Techniques', 'Patch-Clamp Techniques', 'Potassium Channels', 'Preoptic Area', 'Rats', 'Rats, Spragu... | 16,542,780 | [['D02.092.211.111'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D27.505.519.625.725.200.100.100', 'D27.505.696.577.725.200.100.100'], ['D27.505.519.625.725.400.100.100', 'D27.505.696.577.725.400.100.100'], ['B01.050'], ['A08.675.127.500',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2. | Uridine-cytidine kinase (UCK), which converts uridine and cytidine to their corresponding monophosphates, is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Two members of human UCK, named UCK1 and UCK2, were cloned recently and UCK2 was reported to play a crucial role in a... | ['Catalysis', 'Crystallization', 'Crystallography, X-Ray', 'Escherichia coli', 'Humans', 'Ligands', 'Protein Structure, Tertiary', 'Uridine Kinase'] | 12,876,357 | [['G02.130'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['G02.111.570.820.709.610'], ['D08.811.913.696.620.800']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biochemical screening of stable dinucleosomes using DNA fragments from a dinucleosome DNA library. | The dinucleosome is an informative unit for analysis of the higher-order chromatin structure. DNA fragments forming stable dinucleosomes were screened from a dinucleosome DNA library after the reconstitution of nucleosomes in vitro and digestion with micrococcal nuclease. Reconstituted dinucleosomes showed a diversity ... | ['Animals', 'Base Sequence', 'Binding Sites', 'Blotting, Southern', 'Chickens', 'Cloning, Molecular', 'DNA', 'Erythrocytes', 'Gene Library', 'Globins', 'Humans', 'K562 Cells', 'Locus Control Region', 'Micrococcal Nuclease', 'Molecular Conformation', 'Molecular Sequence Data', 'Nucleosomes', 'Protein Binding'] | 15,935,377 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.393.220'], ['D13.444.308'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G05.360.325'], ['D12... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hyperpigmentation, vitiligo, and Addison's disease. | Addison's disease is an uncommon disorder whose dermatologic manifestations range from vitiligo to hyperpigmentation. The association of adrenal autoantibodies and vitiligo has made the latter a possible cutaneous marker for an autoimmune cause. The other cutaneous marker, hyperpigmentation, is now more clearly underst... | ['Addison Disease', 'Adrenocorticotropic Hormone', 'Aged', 'Humans', 'Hydrocortisone', 'Male', 'Melanocyte-Stimulating Hormones', 'Pigmentation Disorders', 'Pro-Opiomelanocortin', 'Vitiligo'] | 2,998,703 | [['C19.053.500.263', 'C20.111.163'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Geometric ray tracing analysis of visual acuity after laser in situ keratomileusis. | PURPOSE: Using a geometric ray tracing model, we explain the increase in visual acuity observed in myopic patients after laser in situ keratomileusis (LASIK).METHODS: This study included 37 eyes of 23 patients who underwent LASIK. All patients had myopia and a spectacle-corrected visual acuity of 0.95 or worse. Clinica... | ['Adult', 'Biometry', 'Corneal Topography', 'Humans', 'Keratomileusis, Laser In Situ', 'Myopia', 'Refraction, Ocular', 'Visual Acuity'] | 11,383,761 | [['M01.060.116'], ['E05.318.740.225', 'N06.850.505.200'], ['E01.370.380.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594.480.750', 'E04.014.520.480.750', 'E04.378.500.750', 'E04.540.825.437.374'], ['C11.744.636'], ['E01.370.380.850.700', 'G01.590.775', 'G14.760'], ['E01.370.380.850.950', 'F02.463.593.9... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells. | Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H., Mernaugh, R., Keeney, D.S., 2003. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J. Biol. Che... | ['Cell Culture Techniques', 'Cell Differentiation', 'Cytochrome P-450 Enzyme System', 'Eicosanoids', 'Epidermal Cells', 'Epidermis', 'Humans', 'Isoenzymes', 'Keratinocytes', 'Male', 'Mixed Function Oxygenases', 'Phenotype', 'RNA, Messenger', 'Up-Regulation'] | 16,307,767 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D10.251.355.255', 'D23.469.050.175'], ['A11.409'], ['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.80... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of physical training on children with bronchial asthma]. | Twelve children with exercise-induced bronchospasm (EIB) participated in our physical training program to determine whether it improves physical working capacity and EIB. The effect of physical training on the bronchial reactivity to inhaled 3.6% NaCl was also investigated. The training was performed by bicycle ergomet... | ['Adolescent', 'Asthma', 'Child', 'Exercise Therapy', 'Female', 'Forced Expiratory Volume', 'Heart Rate', 'Humans', 'Male', 'Oxygen Consumption'] | 2,053,857 | [['M01.060.057'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antigen recognized by monoclonal antibodies to mesencephalic neural crest and to ciliary ganglion neurons is involved in the high affinity choline uptake mechanism in these cells. | High-affinity choline uptake mechanisms are among the characteristics of cholinergic neurons such as the ciliary and choroid subpopulations in the ciliary ganglion (Barald and Berg, 1979). We have produced three monoclonal antibodies (Mabs), two of which were made to 8-day embryonic chick ciliary ganglion (CG) neurons ... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Surface', 'Cells, Cultured', 'Chick Embryo', 'Choline', 'Concanavalin A', 'Flow Cytometry', 'Ganglia, Parasympathetic', 'Neural Crest'] | 3,216,416 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['E01.370.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal Attachment Inventory: expanding the reliability and validity evidence using a sample of Italian women. | BACKGROUND: The Prenatal Attachment Inventory (PAI) is a widely used questionnaire to measure prenatal attachment. However, its internal structure is controversial. None of the previous studies have investigated the dimensions of the Italian version of the scale using both an exploratory and a confirmatory approach. Th... | ['Adult', 'Female', 'Humans', 'Infant', 'Italy', 'Maternal-Fetal Relations', 'Mother-Child Relations', 'Object Attachment', 'Pregnancy', 'Psychometrics', 'Reproducibility of Results', 'Surveys and Questionnaires', 'Young Adult'] | 29,517,386 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['Z01.542.489'], ['F01.829.263.370.215.374', 'F01.829.263.370.290.170.500'], ['F01.829.263.370.290.170'], ['F02.739.794.624'], ['G08.686.784.769'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Halovivax asiaticus gen. nov., sp. nov., a novel extremely halophilic archaeon isolated from Inner Mongolia, China. | Strain EJ-46T, a novel pleomorphic, aerobic, extremely halophilic member of the Archaea was isolated from sediment of the saline Lake Ejinor, in Inner Mongolia, China. This organism was neutrophilic and required at least 15 % (2.5 M) NaCl for growth. MgCl2 was not required. The isolate was able to grow at pH 6.0-9.0. O... | ['China', 'Geologic Sediments', 'Halobacteriaceae', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Archaeal', 'RNA, Ribosomal, 16S', 'Sodium Chloride', 'Water Microbiology'] | 16,585,691 | [['Z01.252.474.164'], ['G01.311.330', 'G16.500.320'], ['B02.200.400.400'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.300'], ['D13.444.735.686.670'], ['D01.210.450.150.875', 'D01.857.650'], ['H01.158.273.540.274.777', 'N06.850.425.450']] | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Phospholipid content, expression and support of thrombin generation of neonatal platelets. | AIM: Newborns have, despite low clotting factors and poor in vitro platelet function, a well functioning haemostasis. We investigated whether phospholipids (PL) in neonatal platelets differ from those in adult platelets in their exposure on the platelet surface, and their effect on thrombin generation.METHODS: The effe... | ['Adult', 'Blood Platelets', 'Humans', 'Infant, Newborn', 'Phospholipids', 'Thrombin'] | 18,976,372 | [['M01.060.116'], ['A11.118.188', 'A15.145.229.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['D10.570.755'], ['D08.811.277.656.300.760.855', 'D08.811.277.656.959.350.855', 'D12.776.124.125.890', 'D23.119.960']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isotope effects accompanying evaporation of water from leaky containers. | Laboratory experiments aimed at quantifying isotope effects associated with partial evaporation of water from leaky containers have been performed under three different settings: (i) evaporation into dry atmosphere, performed in a dynamic mode, (ii) evaporation into dry atmosphere, performed in a static mode, and (iii)... | ['Atmosphere', 'Deuterium', 'Environmental Health', 'Environmental Monitoring', 'Humidity', 'Isotopes', 'Kinetics', 'Models, Biological', 'Oxygen Isotopes', 'Volatilization', 'Water', 'Water Movements', 'Water Supply'] | 18,320,427 | [['G16.500.275.063', 'N06.230.300.100'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['H02.229'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['D01.496'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['D01.2... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Conditional inactivation of HIF-1 using intrabodies. | Hypoxia is a hallmark of solid cancers and triggers the transcription of genes responsible for cell survival. The transcription factor Hypoxia-Inducible Factor 1 (HIF-1) is a key regulator in this response and frequently activated in human cancer. HIF-1 activation is associated with tumor aggressiveness and poor clinic... | ['Animals', 'Antibody Affinity', 'Antibody Specificity', 'Blotting, Western', 'Camelids, New World', 'Cell Line, Tumor', 'Enzyme-Linked Immunosorbent Assay', 'Fluorescent Antibody Technique', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Immunoglobulin Fragments', 'Immunoprecipitation', 'Promoter Regions, Gen... | 18,791,271 | [['B01.050'], ['G12.040', 'G12.122.125'], ['G12.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.190.090'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of tumor necrosis factor alpha in gnotobiotic mice infected with an Escherichia coli O157:H7 strain. | Gnotobiotic mice inoculated with an enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain developed a flaccid paresis, usually culminating in death. The bacteria colonized feces at 10(9) to 10(10) CFU per g (inoculum size: 2.0 x 10(9) CFU/mouse), and Shiga-like toxins (SLTs) were detected in the feces. A microscopic... | ['Animals', 'Bacterial Toxins', 'Brain', 'Colon', 'Colony Count, Microbial', 'Edema', 'Escherichia coli Infections', 'Escherichia coli O157', 'Feces', 'Female', 'Germ-Free Life', 'Guanidines', 'Interleukin-1', 'Interleukin-6', 'Kidney', 'Male', 'Mice', 'Mice, Inbred ICR', 'Protease Inhibitors', 'Shiga Toxins', 'Thrombo... | 9,423,858 | [['B01.050'], ['D23.946.123'], ['A08.186.211'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E01.370.225.875.220', 'E05.200.875.220'], ['C23.888.277'], ['C01.150.252.400.310.330'], ['B03.440.450.425.325.300.800.250.500', 'B03.660.250.150.180.100.800.250.500'], ['A12.459'], ['G06.320'], ['D02.078.370'], ['D12.644.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome. | A relationship exists between exposure to high altitude and increased coagulability. Mean platelet volume is a parameter of platelet functions and may be a marker for increased platelet aggregability. The aim of this study was to compare the mean platelet volumes and platelet counts in patients who experienced an acute... | ['Acute Coronary Syndrome', 'Aged', 'Altitude', 'Atmospheric Pressure', 'Blood Platelets', 'Cell Size', 'Female', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation', 'Platelet Count', 'Thrombophilia'] | 17,978,877 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['G16.500.275.058', 'N06.230.058'], ['G16.500.750.274', 'N06.230.300.100.185'], ['A11.118.188', 'A15.145.229.188'], ['G04.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G09.188.370.687', 'G09.188.390.600.640'], ['E01.370.225.5... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of concurrent calcium ingestion on intestinal absorption of fluoride. | It has been suggested that calcium interferes with absorption of fluoride and that it diminishes the effect this ion has of increasing the bone mass when taken orally. Normal volunteers were given a combination of fluoride and calcium carbonate or fluoride alone, and serum levels of fluoride were measured to determine ... | ['Adult', 'Calcium', 'Calcium Carbonate', 'Female', 'Fluorides', 'Humans', 'Intestinal Absorption', 'Middle Aged', 'Osteoporosis', 'Parathyroid Hormone', 'Phosphorus'] | 672,616 | [['M01.060.116'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Novel form of atrial tachycardia originating at the atrioventricular annulus. | We report two patients with reentrant atrial tachycardia that originated at the AV annulus. Atrial tachycardia originated in the posterior portion of mitral annulus in one patient (case 1) and the posterolateral portion of tricuspid annulus in one patient (case 2). Tachycardia was successfully eliminated by RF catheter... | ['Action Potentials', 'Adolescent', 'Aged', 'Catheter Ablation', 'Humans', 'Male', 'Tachycardia, Atrioventricular Nodal Reentry'] | 9,894,665 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.057'], ['M01.060.116.100'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.067.845.787.249', 'C14.280.123.875.787.249', 'C23.550.073.845.787.500']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
How to interpret a small increase in AUC with an additional risk prediction marker: decision analysis comes through. | An important question in the evaluation of an additional risk prediction marker is how to interpret a small increase in the area under the receiver operating characteristic curve (AUC). Many researchers believe that a change in AUC is a poor metric because it increases only slightly with the addition of a marker with a... | ['Area Under Curve', 'Cesarean Section', 'Decision Support Techniques', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Pregnancy', 'ROC Curve', 'Risk Assessment'] | 24,825,728 | [['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E04.520.252.500'], ['E05.245', 'L01.313.500.750.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['G08.686.784.769'], ['E05.318.370.800.750', 'E05.318.74... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Carbonic anhydrase inhibitory properties of some uracil derivatives. | Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI values of the compounds 4-12 are in the range of 0.085-428 µM for... | ['Carbonic Anhydrase Inhibitors', 'Carbonic Anhydrases', 'Chromatography, Affinity', 'Erythrocytes', 'Humans', 'Isoenzymes', 'Uracil'] | 28,097,897 | [['D27.505.519.389.200'], ['D08.811.520.241.300.150'], ['E05.196.181.400.170'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['D03.383.742.698.875']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of sympathetic innervation loss on mandibular distraction osteogenesis. | Sympathetic nerve system has been proved to have important regulative effects to bone mass. However, the role of sympathetic nerve system in distraction osteogenesis (DO) is unclear. Here we show that the sympathetic nerve system plays an important role in mandibular DO. Thirty male Sprague-Dawley rats were divided int... | ['Animals', 'Bone Density', 'Male', 'Mandible', 'Models, Animal', 'Osteogenesis, Distraction', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Sympathectomy', 'X-Ray Microtomography'] | 22,976,650 | [['B01.050'], ['G11.427.100'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E05.598'], ['E04.555.120.690'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E04.525.210.105.800'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Positive mood as a mediator of the relations among musical preference, postconsumption product evaluation, and consumer satisfaction. | This study of how positive mood mediates the influences of musical preference and postconsumption product evaluation on consumer satisfaction focuses specifically on a model in which positive mood fully mediates the influences. The proposed model is compared with two competing models, and a structural equation model is... | ['Adult', 'Affect', 'Choice Behavior', 'Consumer Behavior', 'Female', 'Humans', 'Male', 'Music'] | 17,688,113 | [['M01.060.116'], ['F01.470.047'], ['F02.463.785.373.346'], ['F01.145.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.602']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Functional and binding studies of the roles of prothrombin and beta 2-glycoprotein I in the expression of lupus anticoagulant activity. | We present functional and binding data relevant to the reported roles for prothrombin and beta 2-glycoprotein I (beta 2GPI) in the expression of lupus anticoagulant activity. In a purified system containing human prothrombin, Xa, Va, and a rate-limiting concentration of phosphatidylserine (PS)/phosphatidylcholine (PC) ... | ['Adult', 'Animals', 'Blood Coagulation', 'Calcium', 'Factor X', 'Female', 'Glycoproteins', 'Humans', 'Immunoglobulin G', 'Lupus Coagulation Inhibitor', 'Male', 'Middle Aged', 'Phospholipids', 'Prothrombin', 'Rabbits', 'Thrombin', 'beta 2-Glycoprotein I'] | 8,180,383 | [['M01.060.116'], ['B01.050'], ['G09.188.390.150'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D08.622.471', 'D12.776.124.125.400', 'D12.776.811.243.471', 'D23.119.400'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.6... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Corneal cell culture and organ storage. | This paper presents methods for corneal cell cultures and examples of investigations that have been performed using these cultures. The techniques and benefits of corneal storage systems, which have arisen from knowledge gained from biologists are outlined. It is likely that both the use of cell culture and organ stora... | ['Animals', 'Cell Division', 'Cells, Cultured', 'Cornea', 'Cytological Techniques', 'Endothelium', 'Epidermal Cells', 'Epithelial Cells', 'Keratins', 'Organ Preservation', 'Rabbits'] | 2,431,524 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A09.371.060.217'], ['E01.370.225.500', 'E05.200.500', 'E05.242'], ['A10.272.491'], ['A11.409'], ['A11.436'], ['D05.750.078.593.450', 'D12.776.220.475.450', 'D12.776.860.607'], ['E02.792.833.660', 'E05.760.833.660'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Investigating the Legacy of the 1918 Influenza Pandemic in Age-Related Seroepidemiology and Immune Responses to Subsequent Influenza A(H1N1) Viruses Through a Structural Equation Model. | A(H1N1) strains of Influenzavirus were responsible for 2 pandemics in the last 100 years. Because infections experienced early in life may have a long-lasting influence on future immune response against other influenza strains, we drew on previously collected seroincidence data from Singapore (n = 2,554; June-October 2... | ['Age Distribution', 'Antibodies, Viral', 'Hemagglutination Tests', 'History, 20th Century', 'Humans', 'Influenza A Virus, H1N1 Subtype', 'Influenza Pandemic, 1918-1919', 'Influenza Vaccines', 'Influenza, Human', 'Models, Theoretical', 'Seroconversion', 'Sex Distribution'] | 30,165,573 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.375'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.48... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Assessing glycolytic flux alterations resulting from genetic perturbations in E. coli using a biosensor. | We describe the development of an optimized glycolytic flux biosensor and its application in detecting altered flux in a production strain and in a mutant library. The glycolytic flux biosensor is based on the Cra-regulated ppsA promoter of E. coli controlling fluorescent protein synthesis. We validated the glycolytic ... | ['Biosensing Techniques', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Knockdown Techniques', 'Glycolysis', 'Promoter Regions, Genetic', 'Pyruvate Synthase'] | 28,709,932 | [['E05.601.043'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['E05.393.335.500'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D08.811.682.657.350.968']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis-acting regulatory elements in the murine Hoxb-6 gene. | Homeobox genes are expressed in stage-, region-, and tissue-specific patterns during embryonic development of the mouse. In order to understand the underlying regulatory mechanisms the murine homeobox gene Hoxb-6 was analyzed for the presence of cis-acting regulatory elements. Transgenic mouse embryos and lines were ge... | ['Animals', 'Embryonic and Fetal Development', 'Extremities', 'Gene Expression', 'Genes, Homeobox', 'Genes, Reporter', 'Mice', 'Mice, Transgenic', 'Regulatory Sequences, Nucleic Acid', 'beta-Galactosidase'] | 8,104,549 | [['B01.050'], ['G07.345.500.325', 'G08.686.784.170'], ['A01.378'], ['G05.297'], ['G05.360.340.024.340.230.500'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['G02.111.570.080.689', 'G05.360.080.689'], ['D08.811.277.450... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects. | The influence of genetic and environmental factors on the metabolism of a single oral dose of ethanol 1.2 ml per kg body weight was analysed in 19 identical and 21 fraternal healthy, adult, un-selected male twin pairs. The heritability values of the rates of absorption, degradation and elimination of ethanol were 0.57,... | ['Adult', 'Alcohol Drinking', 'Ethanol', 'Female', 'Food', 'Humans', 'Intestinal Absorption', 'Kinetics', 'Male', 'Pregnancy', 'Smoking', 'Time Factors', 'Twins, Dizygotic', 'Twins, Monozygotic'] | 560,303 | [['M01.060.116'], ['F01.145.317.269'], ['D02.033.375'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['G01.374.661', 'G02.111.490'], ['G08.686.784.769'], ['F01.145... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. | Despite the characterization of some Burkholderia cepacia complex exopolysaccharides (EPSs), little is known about the role of EPSs in the pathogenicity of B. cepacia complex organisms. We describe 2 Burkholderia cenocepacia (genomovar III) isolates obtained from a patient with cystic fibrosis (CF): the nonmucoid isola... | ['4-Butyrolactone', 'Animals', 'Bacterial Capsules', 'Biofilms', 'Burkholderia Infections', 'Burkholderia cepacia complex', 'Cystic Fibrosis', 'Disease Models, Animal', 'Electrophoresis, Gel, Pulsed-Field', 'Female', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Random Amplified Polymorphic DNA Technique'] | 15,295,701 | [['D02.540.150', 'D03.383.312.150'], ['B01.050'], ['A20.186'], ['A20.593', 'G06.120'], ['C01.150.252.400.170'], ['B03.660.075.090.688.100.110'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.196.401.220', 'E05.301.300.220'], ['B01.050.150.900.649.313.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A case report of malignant mesothelioma]. | A case of successful surgical removal of a primary malignant pericardial mesothelioma was reported. The patient was a 79-year-old man with a complaint of dyspnea at rest. Chest X-ray study showed enlargement of upper mediastinum. Echocardiogram, computed tomography and MRI revealed a giant mass occupying the pericardia... | ['Aged', 'Cardiac Tamponade', 'Heart Neoplasms', 'Humans', 'Male', 'Mesothelioma', 'Pericardial Effusion', 'Pericardium'] | 8,228,423 | [['M01.060.116.100'], ['C14.280.155'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['C14.280.695'], ['A07.541.795', 'A10.615.789.470']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow. | Binding of N-formyl-methionyl-leucyl-phenylalanine (fMLP) to its specific cell surface receptor, N-formyl peptide receptor (FPR), triggers different cascades of biochemical events, eventually leading to cellular activation. However, the physiological role of fMLP and FPR during differentiation of mesenchymal stem cells... | ['Adipocytes', 'Animals', 'Bone Marrow Cells', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Cell Differentiation', 'Cyclosporine', 'Humans', 'Mesenchymal Stem Cells', 'N-Formylmethionine Leucyl-Phenylalanine', 'Osteoblasts', 'PPAR gamma', 'Phospholipase D', 'Rabbits', 'Receptors, Formyl Peptide', 'Signal Tran... | 21,372,136 | [['A11.329.114'], ['B01.050'], ['A11.148', 'A15.378.316'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['G04.152'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['D02.886.030.676.450.44... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Urinary incontinence and quality of life in endometrial cancer patients after robotic-assisted laparoscopic hysterectomy with lymph node dissection. | To determine the long-term effects of lymph node dissection on lower urinary tract symptoms in patients treated for endometrial cancer. We conducted a retrospective cohort study of 74 patients with International Federation of Gynaecology and Obstetrics (FIGO) Stage I endometrial cancer who underwent surgical interventi... | ['Adult', 'Aged', 'Carcinoma', 'Endometrial Neoplasms', 'Female', 'Humans', 'Hysterectomy', 'Laparoscopy', 'Lower Urinary Tract Symptoms', 'Lymph Node Excision', 'Middle Aged', 'Quality of Life', 'Retrospective Studies', 'Robotic Surgical Procedures'] | 31,177,880 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C23.888.942.343'], ['E04.446'], ['M01.060.116.630'], ['I01.80... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Supercritical fluid extraction of persistent organic pollutants from natural and artificial soils and comparison with bioaccumulation in earthworms. | Selective supercritical fluid extraction (SSFE) was used as a measurement of compound chemical accessibility and as a predictor of compound bioavailability from three natural soils and artificial analogues prepared to have comparable total organic carbon content. Soils spiked with phenanthrene, pyrene, PCB 153, lindane... | ['Animals', 'Chromatography, Supercritical Fluid', 'Oligochaeta', 'Polycyclic Aromatic Hydrocarbons', 'Soil', 'Soil Pollutants'] | 23,416,268 | [['B01.050'], ['E05.196.181.750'], ['B01.050.500.091.657'], ['D02.455.426.559.847', 'D04.615'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.888.284.756']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characterisation of three-dimensional anatomic shapes using principal components: application to the proximal tibia. | The objective of the research is to determine if principal component analysis (PCA) provides an efficient method to characterise the normative shape of the proximal tibia. Bone surface data, converted to analytical surface descriptions, are aligned, and an auto-associative memory matrix is generated. A limited subset o... | ['Adult', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Statistics as Topic', 'Tibia', 'Tomography, X-Ray Computed'] | 10,829,384 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['M01.060.116.630'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['A02.835.232.043.650.883'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.37... | ['Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Socialization and attentional deficits under focusing and divided attention conditions. | We conducted two studies to test and refine the hypothesis that, when undersocialized individuals focus on events of immediate interest, they allocate too large a proportion of their processing resources to those events and have little attention available for processing other important events. College students who comp... | ['Adult', 'Antisocial Personality Disorder', 'Attention', 'Humans', 'Individuality', 'Male', 'Motivation', 'Pattern Recognition, Visual', 'Pitch Discrimination', 'Reaction Time', 'Socialization'] | 2,754,605 | [['M01.060.116'], ['F03.675.050'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['F01.658', 'F01.752.543.500.750'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.463.593.071.700.408', 'G07.888.125.700.408'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Mirror trends of plasticity and stability indicators in primate prefrontal cortex. | Research on plasticity markers in the cerebral cortex has largely focused on their timing of expression and role in shaping circuits during critical and normal periods. By contrast, little attention has been focused on the spatial dimension of plasticity-stability across cortical areas. The rationale for this analysis ... | ['Animals', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Glial Fibrillary Acidic Protein', 'Limbic System', 'Macaca mulatta', 'Myelin Sheath', 'Neuronal Plasticity', 'Neurons', 'Parvalbumins', 'Prefrontal Cortex'] | 28,921,934 | [['B01.050'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['A08.186.211.180'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.800.800.690.500', 'A10.755... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in proteins secreted by human fibroblasts and muscle cells in culture. | Cell cultures of human skin fibroblasts, myoblasts, and fused muscle cells were grown in the presence of [14C]leucine or a mixture of [14C]amino acids. The proteins synthesised and secreted or leaked into the culture medium during radio-labelling were separated by one- and two-dimensional PAGE and detected by fluorogra... | ['Amino Acids', 'Carbon Radioisotopes', 'Cells, Cultured', 'Electrophoresis, Polyacrylamide Gel', 'Fibroblasts', 'Humans', 'Kinetics', 'Leucine', 'Molecular Weight', 'Muscles', 'Protein Biosynthesis', 'Proteins', 'Skin'] | 6,468,533 | [['D12.125'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['A11.251'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D12.125.070.637', 'D12.125.142.441'], ['G02.494'], ['A02.633', 'A10.690'], ['G02.111.660.8... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tetrahedral gray code for visualization of genome information. | We propose a tetrahedral Gray code that facilitates visualization of genome information on the surfaces of a tetrahedron, where the relative abundance of each [Formula: see text]-mer in the genomic sequence is represented by a color of the corresponding cell of a triangular lattice. For biological significance, the cod... | ['Animals', 'Bees', 'Color', 'Computational Biology', 'Genome', 'Genomics'] | 24,475,080 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['G01.590.540.199'], ['H01.158.273.180', 'L01.313.124'], ['G05.360.340'], ['H01.158.273.180.350', 'H01.158.273.343.350']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Choice of optimum pharmacokinetic model of orally administered paracetamol. | The present work studies the characterization of the pharmacokinetic profile of paracetamol following oral administration of DUOROL tablets containing 500 mg of the active compound. Analysis is made of the influence of statistical weighting on the selection of the pharmacokinetic model chosen. In the model proposed, th... | ['Acetaminophen', 'Administration, Oral', 'Humans', 'Models, Biological', 'Software'] | 3,207,858 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['E02.319.267.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['L01.224.900']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population. | BACKGROUND: Gastroesophageal reflux disease (GERD), the regurgitation of gastric acids often accompanied by heartburn, affects up to 20% of the general population. Genetic predisposition is suspected from twin and family studies but gene-hunting efforts have so far been scarce and no conclusive genome-wide study has be... | ['Finland', 'Gastroesophageal Reflux', 'Genome-Wide Association Study', 'Humans', 'Population Surveillance', 'Sweden', 'Twin Studies as Topic', 'United Kingdom'] | 27,485,664 | [['Z01.542.816.186'], ['C06.405.117.119.500.484'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.3... | ['Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
TGF-beta1 induces preferential rapid expansion and persistence of tumor antigen-specific CD8+ T cells for adoptive immunotherapy. | Adoptive cell transfer of expanded, autologous tumor-infiltrating lymphocytes (TIL) into lymphodepleted melanoma patients can induce the regression of bulky, metastatic disease. To generate the large numbers of T cells needed for infusion, TIL undergo a rapid expansion protocol (REP) in vitro using anti-CD3 antibody, i... | ['Antigens, Neoplasm', 'CD8-Positive T-Lymphocytes', 'Cell Proliferation', 'Cell Separation', 'Cell Survival', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Flow Cytometry', 'Humans', 'Immunotherapy, Adoptive', 'Interferon-gamma', 'Lymphocytes, Tumor-Infiltrating', 'MART-1 Antigen', 'Melanoma', 'Neoplasm Proteins', ... | 20,386,469 | [['D23.050.285'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G04.346'], ['A11.251'], ['G12.287'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.7... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Investigation of the rh-catalyzed asymmetric reductive aldol reaction. Expanded scope based on reaction analysis. | [reaction: see text] A series of experiments are described that suggest that the Rh-catalyzed reductive aldol reaction proceeds by addition of a Rh(I) hydride, generated in situ, to the reacting acrylate followed by a stereochemistry-controlling aldol addition reaction. On the basis of this hypothesis, reaction conditi... | ['Aldehydes', 'Catalysis', 'Indicators and Reagents', 'Ketones', 'Molecular Structure', 'Rhodium', 'Stereoisomerism'] | 15,228,266 | [['D02.047'], ['G02.130'], ['D27.720.470.410'], ['D02.522'], ['G02.111.570', 'G02.466'], ['D01.268.556.793', 'D01.268.956.781', 'D01.552.544.793'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frequency of D1S80 and HLA DQ alpha alleles in a Chinese population. | Allele frequency distributions for the D1S80 (MCT118) and HLA DQ alpha loci were determined in a Chinese population sample using the polymerase chain reaction (PCR). A total of 25 alleles and 100 phenotypes were observed for D1S80. The frequency of allele 18 was higher than allele 24 only in this Chinese population whe... | ['Asian Continental Ancestry Group', 'China', 'Gene Frequency', 'Genetic Markers', 'Genetics, Population', 'HLA-DQ Antigens', 'Humans', 'Polymerase Chain Reaction', 'Reproducibility of Results'] | 8,664,158 | [['M01.686.508.200'], ['Z01.252.474.164'], ['G05.330'], ['D23.101.387', 'G05.695.450'], ['H01.158.273.343.335'], ['D12.776.395.550.509.400.430', 'D12.776.543.550.440.400.430', 'D23.050.301.500.400.400.430', 'D23.050.301.500.450.400.430', 'D23.050.705.552.410.400.430', 'D23.050.705.552.450.400.430'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
[The effect of SSH&H on the lifespan and spontaneous cancer development in transgenic mice with HER-2/neu mutation]. | 10 months old mice receiving SSH&H with daily food increased the lifespan in comparison to the control group. The maximal lifespan was increased by 1,6 months. For the long-living 10% group the mean lifespan increased by 8,7% compared to the control group (p<0,05). The mammary gland neoplasia rate was the same in both ... | ['Animals', 'Anticarcinogenic Agents', 'Female', 'Food Additives', 'Lung Neoplasms', 'Mammary Neoplasms, Animal', 'Mammary Neoplasms, Experimental', 'Mice', 'Mice, Transgenic', 'Mutation', 'Receptor, ErbB-2'] | 22,774,532 | [['B01.050'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['D27.720.372.300', 'G07.203.300.514.500', 'J02.500.514.500'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.588.531', 'C22.520'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Prolactinomas: evolution after menopause. | OBJETIVE: The aim was to assess the evolution of tumor size and prolactin (PRL) levels in patients with micro and macroprolactinomas diagnosed and treated with dopamine agonists during fertile age, and the effects of suspension of drugs after menopause.SUBJECTS AND METHODS: Retrospective study, 29 patients with prolact... | ['Adenoma', 'Adult', 'Bromocriptine', 'Cabergoline', 'Disease Progression', 'Dopamine Agonists', 'Ergolines', 'Female', 'Humans', 'Menopause', 'Middle Aged', 'Pituitary Neoplasms', 'Prolactin', 'Prolactinoma', 'Retrospective Studies', 'Treatment Outcome', 'Withholding Treatment'] | 26,909,481 | [['C04.557.470.035'], ['M01.060.116'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['D03.132.327.287.131', 'D03.633.400.439.197'], ['C23.550.291.656'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['D03.132.327.287', 'D03.633.400.439'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of microporation on passive and iontophoretic delivery of diclofenac sodium. | Skin pretreatment with a microneedle roller (microporation (MP)) appears a simple and inexpensive technique to increase transdermal delivery of topically applied drug products. This study investigates the effect of MP on the passive and iontophoretic delivery of diclofenac (DCF) by quantifying dermis and plasma levels ... | ['Administration, Cutaneous', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Diclofenac', 'Drug Delivery Systems', 'Female', 'Iontophoresis', 'Microdialysis', 'Organ Culture Techniques', 'Rabbits', 'Skin Absorption', 'Transdermal Patch'] | 25,758,411 | [['E02.319.267.120.060'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.241.223.601.210'], ['E02.319.300'], ['E02.319.267.650', 'E05.301.300.575'], ['E05.196.353.500'], ['E05.481.500.484'], ['B01.050.150.900.649.313.968.700'], ['G03.015.500.750', 'G03.787.024.500.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. | BACKGROUND: Amino acid transporters are highly expressed in various human cancers. L-type amino acid transporter 1 (LAT1) and system alanine-serine-cysteine amino acid transporter-2 (ASCT2) play a crucial role in tumor progression and survival. However, the clinicopathological significance of these transporters in pati... | ['Adult', 'Aged', 'Aged, 80 and over', 'Amino Acid Transport System ASC', 'Biomarkers, Tumor', 'Carcinoma, Squamous Cell', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Female', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Large Neutral Amino Acid-Transporter 1', 'Male', 'Middle Aged', '... | 26,936,531 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.157.530.200.500.200', 'D12.776.543.585.200.500.200'], ['D23.101.140'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['C04.557.470.200.400.330'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Radioimmunological measurement of beta-endorphin in equine plasma. | Radioimmunoassay procedures were developed and validated for the quantification of beta-endorphin (beta-EP)-like immunoreactivity in equine plasma. beta-EP could be quantitatively extracted from plasma with silicic acid powder and subsequently assayed, however, valid estimates of this hormone could also be obtained on ... | ['Animals', 'Antibody Specificity', 'Chromatography, Gel', 'Endorphins', 'Female', 'Horses', 'Male', 'Radioimmunoassay', 'Silicic Acid', 'beta-Endorphin', 'beta-Lipotropin'] | 6,306,677 | [['B01.050'], ['G12.100'], ['E05.196.181.400.250'], ['D12.644.400.575.241', 'D12.776.631.650.575.241'], ['B01.050.150.900.649.313.984.235.472'], ['E01.370.384.700', 'E05.478.566.639', 'E05.601.470.639'], ['D01.029.260.863', 'D01.837.725.700'], ['D06.472.699.327.935.239', 'D06.472.699.631.525.600.239', 'D12.644.400.400.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluating outcome-correlated recruitment and geographic recruitment bias in a respondent-driven sample of people who inject drugs in Tijuana, Mexico. | Respondent-driven sampling's (RDS) widespread use and reliance on untested assumptions suggests a need for new exploratory/diagnostic tests. We assessed geographic recruitment bias and outcome-correlated recruitment among 1,048 RDS-recruited people who inject drugs (Tijuana, Mexico). Surveys gathered demographics, drug... | ['Adult', 'Bias', 'Female', 'HIV Infections', 'Humans', 'Male', 'Mexico', 'Outcome Assessment, Health Care', 'Patient Selection', 'Prevalence', 'Risk Factors', 'Sampling Studies', 'Substance Abuse, Intravenous', 'Syphilis', 'Tuberculosis'] | 24,969,586 | [['M01.060.116'], ['N05.715.350.150', 'N06.850.490.500'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.589'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], [... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Philosophical conjectures and their refutation. | Sir Karl Popper is well known for explicating science in falsificationist terms, for which his degree of corroboration formalism, C(h,e,b), has become little more than a symbol. For example, de Queiroz and Poe in this issue argue that C(h,e,b) reduces to a single relative (conditional) probability, p(e,hb), the likelih... | ['Likelihood Functions', 'Models, Genetic', 'Philosophy', 'Phylogeny', 'Probability Theory'] | 12,116,578 | [['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['E05.599.395.397'], ['K01.752'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['L01.906.394.622']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The Mother-Child Relationship during the First Months of Life: Preliminary Considerations in Preterm as Compared with Term Mother-Infant Dyads. | INTRODUCTION: From the prognostic perspective, the quality of the mother-child relationship during the first months of life has been variously associated with different factors such as the child's psychomotor/cognitive development and emotional-behavioral disorders.METHODS: The main aim of this study was to describe,... | ['Child Development', 'Female', 'Gestational Age', 'Humans', 'Infant Behavior', 'Infant, Newborn', 'Infant, Premature', 'Italy', 'Male', 'Mother-Child Relations', 'Mothers', 'Term Birth'] | 29,695,001 | [['F01.525.200', 'G07.345.374.750'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.179.500'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['Z01.542.489'], ['F01.829.263.370.290.170'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Use of densitometric analysis for interpreting HSV serologies based on Western blot. | Western blot assays have been described for detecting antibodies to herpes simplex virus (HSV). A predominance of antibody binding to either the HSV-1 or the HSV-2-containing blot has been reported to indicate infection with HSV-1 or HSV-2, respectively. By densitometry, differential binding of total antibody on HSV-1 ... | ['Antibodies, Viral', 'Antigens, Viral', 'Densitometry', 'Herpes Simplex', 'Humans', 'Serotyping', 'Simplexvirus'] | 2,828,399 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['E05.196.712.224'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.742', 'E01.370.225.875.150.125.890', 'E05.200.812.74... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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