Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Acute phase response and energy balance in stable human immunodeficiency virus-infected patients: a doubly labeled water study. | We sought to assess possible associations of the acute phase response with energy balance as a cause of malnutrition in uncomplicated HIV-infection. Seven stable HIV-infected patients and 7 control subjects were followed for 2 weeks for blood chemistry, body composition, total and resting energy expenditure (TEE, REE),... | ['Acute-Phase Reaction', 'Adult', 'Body Composition', 'Calorimetry', 'Electric Impedance', 'Energy Metabolism', 'Exercise', 'HIV Infections', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Potassium, Dietary', 'Receptors, Interleukin-2', 'Water'] | 11,477,375 | [['C23.550.470.099'], ['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E05.196.131'], ['G01.358.500.249.277.350'], ['G03.295'], ['G11.427.410.698.277', 'I03.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['E01.370.600.875.5... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Synaptophysin--a common constituent of presumptive secretory microvesicles in the mammalian pinealocyte: a study of rat and gerbil pineal glands. | Recent studies have established that pinealocytes of the mammalian pineal gland contain marker molecules of neuroendocrine cells or paraneurons like the synaptic vesicle-associated protein synaptophysin (p38). The objective of this study was to identify the subcellular synaptophysin-positive compartment and to characte... | ['Animals', 'Blotting, Western', 'Densitometry', 'Gerbillinae', 'Image Processing, Computer-Assisted', 'Immunohistochemistry', 'Microscopy, Electron', 'Pineal Gland', 'Rats', 'Rats, Inbred Lew', 'Rats, Wistar', 'Synaptophysin'] | 8,423,638 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.196.712.224'], ['B01.050.150.900.649.313.992.635.300'], ['L01.224.308'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Variation in mammographic breast density by time in menstrual cycle among women aged 40-49 years. | BACKGROUND: Mammography is less effective for women aged 40-49 years than for older women, which has led to a call for research to improve the performance of screening mammography for younger women. One factor that may influence the performance of mammography is breast density. Younger women have greater mammographic b... | ['Adult', 'Age Factors', 'Breast Neoplasms', 'Female', 'Follicular Phase', 'Humans', 'Luteal Phase', 'Mammography', 'Menstrual Cycle', 'Middle Aged', 'Time Factors'] | 9,637,139 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.180', 'C17.800.090.500'], ['G08.686.605.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.605.410'], ['E01.370.350.700.500'], ['G08.686.605'], ['M01.060.116.630'], ['G01.910.857']] | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq. | 4sUDRB-seq separately measures, on a genomic scale, the distinct contributions of transcription elongation speed and rate of RNA polymerase II (Pol II) transition into active elongation (TAE) to the overall mRNA production rate. It uses reversible inhibition of transcription elongation with 5,6-dichloro-1-â-D-ribofuran... | ['Biotin', 'Dichlororibofuranosylbenzimidazole', 'Genome', 'HeLa Cells', 'Humans', 'RNA', 'RNA Polymerase II', 'Reproducibility of Results', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Analysis, RNA', 'Streptavidin', 'Thiouridine', 'Transcription Elongation, Genetic'] | 25,811,895 | [['D03.383.129.308.080', 'D08.211.096'], ['D13.570.800.330'], ['G05.360.340'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.444.735'], ['D08.811.913.696.445.735.270.762'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Complications of invasive, urodynamic examinations and prostate biopsies in patients with benign prostatic hyperplasia. | We studied 85 men with moderate to severe symptoms of benign prostatic hyperplasia (BPH) who completed two placebo-controlled studies of drug therapy. During the 48 week period of treatment and follow-up the patients underwent 164 procedures which included urethral instrumentation, predominantly without antibiotic prop... | ['Aged', 'Anti-Bacterial Agents', 'Biopsy, Needle', 'Cystoscopy', 'Humans', 'Incidence', 'Male', 'Prognosis', 'Prostatic Hyperplasia', 'Rheology', 'Urinary Catheterization', 'Urinary Tract Infections', 'Urodynamics'] | 8,578,262 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E01.370.388.250.180', 'E01.370.390.175', 'E04.502.250.180', 'E04.950.774.155'], ['B01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Differentiation of a mouse submandibular gland-derived cell line (SCA) grown on matrigel. | SCA-9 cell line was developed from an induced tumor of mouse submandibular gland. We have studied some of the phenotypic characteristics of SCA cells cultured on different matrices. On plastic surface, the cells grow as a monolayer; on matrigel, they form branching structures and tubes, a phenomenon termed branching mo... | ['Animals', 'Cell Differentiation', 'Cell Line, Tumor', 'Collagen', 'Drug Combinations', 'Epidermal Growth Factor', 'Epithelial Cells', 'ErbB Receptors', 'Hepatocyte Growth Factor', 'Laminin', 'Male', 'Mice', 'Morphogenesis', 'Phenotype', 'Proteoglycans', 'RNA, Messenger', 'Receptor, ErbB-2', 'Receptor, ErbB-3', 'Recep... | 15,922,327 | [['B01.050'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D26.310'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['A11.436'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building. | UNLABELLED: We investigated the associations of fungal and endotoxin levels in office dust with respiratory health in 888 (67% participation) occupants of a water-damaged building. We analyzed floor and chair dusts from 338 workstations for culturable fungi and endotoxin. Based on averages, we ranked each floor of the ... | ['Air Pollution, Indoor', 'Antigens, Fungal', 'Dust', 'Endotoxins', 'Environmental Monitoring', 'Epidemiological Monitoring', 'Fungi', 'Housing', 'Humans', 'Occupational Exposure', 'Respiratory Hypersensitivity', 'Water'] | 16,683,938 | [['N06.850.460.100.080'], ['D23.050.202'], ['D20.633.222'], ['D23.946.123.329'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.318.375', 'N06.850.520.460'], ['B01.300'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.6... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Herbicidal effects of statin pharmaceuticals in Lemna gibba. | Statin pharmaceuticals, heavily prescribed in the treatment of hypercholesterolemia, are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR). In plants, these compounds also inhibit HMGR, which regulates cytosolic isoprenoid biosynthesis in the mevalonic acid (MVA) pathway. Phytotoxicity wa... | ['Atorvastatin', 'Chromatography, High Pressure Liquid', 'Heptanoic Acids', 'Herbicides', 'Hydroxymethylglutaryl CoA Reductases', 'Lovastatin', 'Mevalonic Acid', 'Models, Chemical', 'Pharmaceutical Preparations', 'Plants', 'Plastoquinone', 'Pyrroles', 'Risk Assessment', 'Sitosterols', 'Sterols', 'Ubiquinone', 'Ultravio... | 16,955,916 | [['D03.383.129.578.075', 'D10.251.450.200'], ['E05.196.181.400.300'], ['D10.251.450'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D08.811.682.047.820.150.415'], ['D02.455.426.559.847.638.400', 'D04.615.638.400'], ['D02.241.511.579'], ['E05.599.495'], ['D26'], ['B01.650'], ['D02.806.250.700'], ['D03.383.129.578'], ['... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin. | Alcohol dehydrogenase (ADH; EC 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3.) are important enzymes involved in the biotransformation of both alcohols and aldehydes. Today, six classes of ADH and twelve classes of ALDH have been defined in mammals. Here we report the detection and localisation of three classes... | ['Adolescent', 'Adult', 'Aged', 'Alcohol Dehydrogenase', 'Aldehyde Dehydrogenase', 'Blotting, Western', 'Child', 'Child, Preschool', 'Cytosol', 'Dermis', 'Epidermis', 'Female', 'Humans', 'Immunohistochemistry', 'Infant', 'Male', 'Middle Aged', 'Molecular Weight', 'Skin'] | 10,405,330 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.682.047.820.250'], ['D08.811.682.657.163.249'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['M01.060.406'], ['M01.060.406.448'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of some antihypertensive drugs on cutaneous blood flow and inflammatory skin responses following allergen challenge in guinea pigs. | The effects of the antihypertensive drugs clonidine, prazosin, and MK 422 (the active parent diacid of enalapril) were studied on the cutaneous blood flow and allergen evoked inflammatory skin reactions in ovalbumin sensitized guinea pigs. The hypotensive effect of the drugs did not significantly change the basal cutan... | ['Allergens', 'Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Antihypertensive Agents', 'Clonidine', 'Dermatitis', 'Enalapril', 'Enalaprilat', 'Female', 'Guinea Pigs', 'Ovalbumin', 'Prazosin', 'Regional Blood Flow', 'Skin'] | 3,039,481 | [['D23.050.063'], ['D27.505.519.389.745.085'], ['B01.050'], ['D27.505.954.411.162'], ['D03.383.129.308.436.500'], ['C17.800.174'], ['D12.644.456.345.360'], ['D12.644.456.345.360.300'], ['B01.050.150.900.649.313.992.550'], ['D12.644.861.557', 'D12.776.034.614', 'D12.776.256.159.157.663', 'D12.776.290.663', 'D12.776.872.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Decisions for institutionalization among nursing home residents and their children in Shanghai. | An increasing number of elders in Shanghai have moved into nursing homes to meet their needs for long-term care. This shift from family caregiving to nursing home care calls for an exploration of caregiving decision making in urban China. In this article I present both generations' experiences of deciding to institutio... | ['Aged', 'Aged, 80 and over', 'Caregivers', 'China', 'Cultural Characteristics', 'Decision Making', 'Female', 'Health Status', 'Humans', 'Institutionalization', 'Intergenerational Relations', 'Interviews as Topic', 'Male', 'Nursing Homes', 'Parent-Child Relations'] | 25,231,946 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['Z01.252.474.164'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['F02.463.785.373'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.415', 'N02.421.585.415... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
External rhinoplasty technique. | External rhinoplasty is a valuable tool in the surgical armamentarium of all nasal surgeons. It does not change the dynamics of the operation but offers a new method of exposure. The purpose of this paper is to present our experience with the external rhinoplasty technique in 601 patients, and review the results and co... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Reoperation', 'Rhinoplasty'] | 2,256,651 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.690'], ['E02.218.755', 'E04.580.392.500', 'E04.680.650']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A methyltransferase for synthesis of the flavanone phytoalexin sakuranetin in rice leaves. | Rice (Oryza sativa L.) leaves irradiated with short wave UV light accumulated the major rice phytoalexin, flavanone sakuranetin. The extracts from these leaves catalyzed the methylation of the hydroxyl group at position 7 of naringenin to yield sakuranetin, with S-adenosyl-L-methionine as the methyl donor. Activity of ... | ['Enzyme Induction', 'Flavanones', 'Flavonoids', 'Methyltransferases', 'Oryza', 'Plant Extracts', 'Sesquiterpenes', 'Substrate Specificity', 'Terpenes'] | 8,651,913 | [['G05.308.320.200'], ['D03.383.663.283.266.450.252', 'D03.633.100.150.266.450.252'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D08.811.913.555.500'], ['B01.650.940.800.575.912.250.822.616'], ['D20.215.784.500', 'D26.667'], ['D02.455.849.765'], ['G02.111.835'], ['D02.455.849']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Obesity and the aging adult: ideas for promoting patient safety and preventing caregiver injury. | Some experts contend that the increasing prevalence of obesity among patients and caregivers leads to more frequent and serious musculoskeletal injuries among caregivers. Others believe that failure to ensure safe, appropriate equipment and supporting policies leads to the increasing prevalence of caregiver injuries. H... | ['Aged', 'Caregivers', 'Humans', 'Obesity', 'Pressure Ulcer', 'Safety', 'Wounds and Injuries'] | 16,182,088 | [['M01.060.116.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C17.800.893.665'], ['N06.850.135.060.075'], ['C26']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients. | The efficacy of voriconazole in 107 patients with scedosporiosis was analyzed. Principal infection sites were the lungs/sinuses (24%), central nervous system (CNS) (20%), and bone (18%), while 21% of patients had disseminated infection. Solid organ transplantation (22%), hematological malignancy (21%), and surgery/trau... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antifungal Agents', 'Aspergillosis', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Female', 'Health Surveys', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Pyrimidines', 'Scedosporium', 'Treatment Outcome', 'Triazoles', 'Voriconazole'] | 18,212,110 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.136'], ['C01.150.703.080'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term outcome after switch from cyclosporine-based triple-drug immunosuppression to double therapy at three months. | Cyclosporin A (CyA) together with steroids and azathioprine (Aza) has been successfully used for prophylactic immunosuppression in numerous recipients of kidney allografts. The aim of this study was to evaluate the long-term effect of reducing this initial triple-drug therapy to double-drug therapy at 3 months. One hun... | ['Adolescent', 'Adult', 'Aged', 'Azathioprine', 'Cadaver', 'Cyclosporine', 'Drug Combinations', 'Female', 'Follow-Up Studies', 'Glucocorticoids', 'Graft Rejection', 'Graft Survival', 'Humans', 'Immunosuppression', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Methylprednisolone', 'Middle Aged', 'Prospe... | 8,664,521 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.886.759.111', 'D03.633.100.759.570.090', 'D13.570.900.111'], ['C23.550.260.224'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D26.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D06.472.040.543', 'D27... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brain intracellular metabolites are freely diffusing along cell fibers in grey and white matter, as measured by diffusion-weighted MR spectroscopy in the human brain at 7 T. | Due to the specific compartmentation of brain metabolites, diffusion-weighted magnetic resonance spectroscopy opens unique insight into neuronal and astrocytic microstructures. The apparent diffusion coefficient (ADC) of brain metabolites depends on various intracellular parameters including cytosol viscosity and molec... | ['Adult', 'Astrocytes', 'Brain', 'Diffusion', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Gray Matter', 'Humans', 'Magnetic Resonance Spectroscopy', 'Male', 'Neurons', 'White Matter', 'Young Adult'] | 25,520,054 | [['M01.060.116'], ['A08.637.200', 'A11.650.200'], ['A08.186.211'], ['G01.202', 'G02.196'], ['E01.370.350.825.500.150'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['A08.675', 'A11.671'], ['A08.186.211.204', 'A08.186.854.880'], ['M01.060.116.815']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Iloprost-induced inhibition of proliferation of coronary artery smooth muscle cells is abolished by homologous desensitization. | In addition to inhibition of platelet function, prostacyclin and its stable analogues are reported to attenuate vascular smooth muscle cell proliferation. However, desensitization of prostacyclin responsiveness is a known phenomenon in platelets. In this study we investigated the time-dependent effects of the prostacyc... | ['Alprostadil', 'Animals', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Cattle', 'Cell Division', 'Cells, Cultured', 'Colforsin', 'Coronary Vessels', 'Female', 'Fluorides', 'Iloprost', 'Muscle, Smooth, Vascular', 'Platelet-Derived Growth Factor', 'Prostaglandin-Endoperoxide Synthases', 'Radioimmunoassay', 'Time Fac... | 7,536,386 | [['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['B01.050'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['B01.050.150.900.649.313.500.380.271'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D02.455.849.29... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. | The role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial. This study included 182 Caucasian subjects, 47 breast cancer (BC) cases and 135 matched controls. We used the Amp... | ['Antineoplastic Agents, Hormonal', 'Aryl Hydrocarbon Hydroxylases', 'Arylsulfotransferase', 'Breast Neoplasms', 'Case-Control Studies', 'Clinical Trials as Topic', 'Cytochrome P-450 CYP2C19', 'Cytochrome P-450 CYP2D6', 'Drug Resistance, Neoplasm', 'Female', 'Humans', 'Italy', 'Middle Aged', 'Polymorphism, Single Nucle... | 20,309,015 | [['D27.505.954.248.169'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D08.811.913.817.400.300'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma. | Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor. however, its pathological mechanisms have not yet been elucidated. In the present study, we screened for candidate tumor-suppressor genes (TSGs) related to OSCC among 10 candidate genes loca... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Apoptosis Regulatory Proteins', 'Base Sequence', 'Carcinoma, Squamous Cell', 'Cell Line, Tumor', 'Chromosomes, Human, Pair 3', 'DNA Methylation', 'Female', 'Genes, Tumor Suppressor', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Heterotrimeric... | 23,292,452 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.644.360.075', 'D12.776.476.075'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.187.520.300.235.250', 'G05.360.162.520.300... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes. | The Xp22.1-p22.2 interval is a focus of interest as a number of hereditary disease loci have been mapped to this region, including X-linked nonsyndromic sensorineural deafness (DFN6), X-linked juvenile retinoschisis (RS), and several X-linked mental retardation syndromes. In the course of cloning the RS gene we have as... | ['Amino Acid Sequence', 'Chromosome Mapping', 'Chromosomes, Human', 'Exons', 'Gene Expression', 'Humans', 'Molecular Sequence Data', 'RNA, Messenger', 'Sequence Homology, Amino Acid', 'Sex Chromosome Aberrations', 'Transcription, Genetic', 'X Chromosome'] | 9,693,033 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.183'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['G05.360.340.024.340.137.232'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D13.444.735.544'], ['G02.111.810.200', 'G05.810.200'], ['C23.550.210.815', 'G05.365.590.175.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone. | In the present study the physicochemical characteristics of dihydroartemisinin, polyvinylpyrrolidone and their solid dispersions were evaluated at various proportions of drug and polyvinylpyrrolidone. These properties were investigated with X-ray diffraction, fourier transform infrared spectrophotometry, differential s... | ['Antimalarials', 'Artemisinins', 'Calorimetry, Differential Scanning', 'Chemistry, Pharmaceutical', 'Drug Carriers', 'Drug Compounding', 'Hydrogen Bonding', 'Povidone', 'Sesquiterpenes', 'Solubility', 'Solvents', 'Spectroscopy, Fourier Transform Infrared', 'Technology, Pharmaceutical', 'Temperature', 'Thermodynamics',... | 18,409,055 | [['D27.505.954.122.250.100.085'], ['D01.248.497.158.685.750.212', 'D01.339.431.374.212', 'D01.650.550.750.200', 'D02.389.338.055', 'D02.455.849.765.211'], ['E05.196.131.310', 'E05.196.370.310'], ['H01.158.703.007', 'H01.181.466'], ['D26.255.260', 'E02.319.300.380'], ['E05.916.270'], ['G02.282'], ['D02.455.326.271.884.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Limitations of the CLEA model when assessing human health risks from dioxins and furans in soil at an allotments site in Rochdale, NW England. | Many allotments in the UK today are situated on urban brownfield areas which creates a potential human health risk from soil borne contamination. This paper looks specifically at the risks to allotment users at a site in Rochdale, UK, from polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-furans (PCDD and P... | ['Benzofurans', 'Dibenzofurans, Polychlorinated', 'Eggs', 'England', 'Environmental Exposure', 'Food Contamination', 'Gardening', 'Humans', 'Models, Biological', 'Models, Chemical', 'Polychlorinated Dibenzodioxins', 'Risk Assessment', 'Soil', 'Soil Pollutants'] | 21,611,642 | [['D03.633.100.127'], ['D02.309.250', 'D03.633.300.258.500'], ['G07.203.300.470', 'J02.500.470'], ['Z01.542.363.300'], ['N06.850.460.350'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['I03.450.642.581.500', 'J01.040.498.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.39... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. | BACKGROUND: Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis and increased cardiovascular morbidity and mortality. Striking similarities exist in the inflammatory and immunologic response in RA and atherosclerosis. Indeed, adhesion molecules and cytokines, tumor necrosis factor (TNF)-alpha in pa... | ['Antibodies, Monoclonal', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Brachial Artery', 'C-Reactive Protein', 'Endothelium, Vascular', 'Female', 'Humans', 'Infliximab', 'Male', 'Middle Aged', 'Tumor Necrosis Factor-alpha', 'Ultrasonography', 'Vasodilation'] | 12,390,945 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A07.015.114.139'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['A07.015.700.500', 'A10.272.491.355'], ['B01... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clusterin deficiency induces lipid accumulation and tissue damage in kidney. | Clusterin is a secretory glycoprotein that is involved in multiple physiopathological processes, including lipid metabolism. Previous studies have shown that clusterin prevents hepatic lipid accumulation via suppression of sterol regulatory element-binding protein (SREBP) 1. In this study, we examined the role of clust... | ['Animals', 'Cells, Cultured', 'Clusterin', 'Fibrosis', 'Gene Deletion', 'Kidney', 'Lipid Metabolism', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Rats', 'Renal Insufficiency, Chronic', 'Transforming Growth Factor beta1', 'Up-Regulation'] | 29,563,234 | [['B01.050'], ['A11.251'], ['D12.776.395.207', 'D12.776.580.215'], ['C23.550.355'], ['G05.365.590.762.320', 'G05.558.800.320'], ['A05.810.453'], ['G03.458'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', 'B01.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of MoSe₂ Nano-Urchins as a Sensing Platform for a Selective Bio-Capturing of Escherichia. coli Shiga Toxin DNA. | The present study was aimed to develop "fluorine doped" tin oxide glass electrode with a MoSe2 nano-urchin based electrochemical biosensor for detection of Escherichia. coli Shiga toxin DNA. The study comprises two conductive electrodes, and the working electrodes were drop deposited using MoSe2 nano-urchin, and DNA se... | ['Biosensing Techniques', 'DNA, Bacterial', 'Electrochemical Techniques', 'Electrodes', 'Escherichia coli', 'Methylene Blue', 'Molybdenum', 'Nanostructures', 'Selenium Compounds', 'Shiga Toxin', 'Spectroscopy, Fourier Transform Infrared', 'Tin Compounds'] | 30,110,986 | [['E05.601.043'], ['D13.444.308.212'], ['E05.301'], ['E07.305.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.886.369.517', 'D03.633.300.783.517'], ['D01.268.556.555', 'D01.268.956.500', 'D01.552.544.555'], ['J01.637.512'], ['D01.810'], ['D08.811.277.450.430.700.750.750.100', 'D23.946.123.794.095',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Inhibition of Ca++-stimulated respiration by uncouplers. | In a phosphate medium at pH 6.6 low concentrations of uncouplers such as p-trifluoromethoxyphenylhydrazone carbonylcyanide and 2,4-dinitrophenol inhibit the oxidation of beta-hydroxybutyrate and succinate, when added during Ca++-accumulation. The inhibition depends on the amount of accumulated Ca++, and is released by ... | ['Animals', 'Calcium', 'Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone', 'Dinitrophenols', 'Electron Transport', 'Hydrogen-Ion Concentration', 'Mitochondria, Liver', 'Oxidative Phosphorylation', 'Oxygen Consumption', 'Rats', 'Tetramethylphenylenediamine', 'Uncoupling Agents'] | 9,761 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.442.288.220', 'D02.626.270'], ['D02.455.426.559.389.657.566.304', 'D02.640.743.304'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G02.300'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['G02.111.665.550', 'G03.295.631', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of multiline two-photon microscopy to functional in vivo imaging. | High spatial resolution and low risks of photodamage make two-photon laser-scanning microscopy (TPLSM) the method of choice for biological imaging. However, the study of functional dynamics such as neuronal calcium regulation often also requires a high temporal resolution. Hitherto, acquisition speed is usually increas... | ['Animals', 'Calcium Signaling', 'Diptera', 'Equipment Design', 'Equipment Failure Analysis', 'Image Enhancement', 'Microscopy, Confocal', 'Microscopy, Fluorescence, Multiphoton', 'Motion Perception', 'Neurons, Afferent', 'Visual Cortex'] | 16,442,636 | [['B01.050'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['B01.050.500.131.617.720.500.500.750'], ['E05.320'], ['E05.325.192'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.458.500', 'E01.370.350.515.717.250', 'E05.595.458.500', 'E05.595.717.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Helplessness predicts the development of hypertension in older Mexican and European Americans. | OBJECTIVE: The mechanisms by which depression is associated with an elevated risk of cardiovascular disease remain unclear. It is possible that depressive symptoms could increase the risk of hypertension, which in turn could predispose to cardiovascular disease. The goal of this study was to explore whether individual ... | ['Age Factors', 'Aged', 'Cohort Studies', 'Depressive Disorder, Major', 'European Continental Ancestry Group', 'Female', 'Helplessness, Learned', 'Humans', 'Hypertension', 'Longitudinal Studies', 'Male', 'Mexican Americans', 'Middle Aged', 'Motivation', 'Risk Factors', 'Self Concept', 'Sex Factors', 'Socioeconomic Fact... | 19,773,026 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['F03.600.300.375'], ['M01.686.508.400'], ['F01.393.398', 'F02.463.425.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E05.318.372.500.750.500', 'N05.71... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The role of general practitioners in diagnosis of cutaneous melanoma: a population-based study in France. | BACKGROUND: Little data are available concerning the role of general practitioners (GPs) in the diagnosis of melanoma.OBJECTIVES: To evaluate the actual role of GPs in a population-based study covering five regions of France and 8·2 million inhabitants.MATERIALS AND METHODS: A survey of cancer registries and pathology ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Female', 'France', 'General Practitioners', 'Humans', 'Male', 'Melanoma', 'Middle Aged', 'Multivariate Analysis', "Physician's Role", 'Skin Neoplasms', 'Young Adult'] | 22,834,687 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['Z01.542.286'], ['M01.526.485.810.485', 'N02.360.810.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['E05.318.740.15... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Case from the aerospace medicine residents' teaching file. Pigment dispersion syndrome. | A case report is presented of a student naval flight officer with pigment dispersion syndrome. The diagnosis, treatment, and aeromedical disposition of this condition are discussed. | ['Adult', 'Aerospace Medicine', 'Exfoliation Syndrome', 'Humans', 'Iris', 'Male'] | 12,546,305 | [['M01.060.116'], ['H02.403.029'], ['C11.941.375.285'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.060.450', 'A09.371.894.513']] | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic diversity of the dnaJ gene in the Mycobacterium avium complex. | The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21-32 nucleotides, all strains could be classified into 14 gr... | ['Animals', 'Bacterial Proteins', 'Bacterial Typing Techniques', 'Base Sequence', 'DNA, Bacterial', 'Genetic Variation', 'HSP40 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Humans', 'Molecular Epidemiology', 'Molecular Sequence Data', 'Mycobacterium avium Complex', 'Phylogeny', 'Point Mutation', 'Sequence Alignment', ... | 15,272,071 | [['B01.050'], ['D12.776.097'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['G05.365'], ['D12.776.580.216.292'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.416', 'E05.393.522', 'H01.158.201.636.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Tubal sterilization by laparoscopy or hysteroscopy: which is the most cost-effective procedure? | By using the activity-based cost/management (ABC/M) system we computed and compared costs needed for laparoscopic tubal sterilization (LTS) and Essure hysteroscopic tubal occlusion (EHTO). We found that total health costs related to consultation and presurgery did not differ between LTS and EHTO; EHTO has low recovery ... | ['Cost-Benefit Analysis', 'Female', 'Health Care Costs', 'Humans', 'Hysteroscopy', 'Italy', 'Laparoscopy', 'Postoperative Care', 'Preoperative Care', 'Referral and Consultation', 'Retrospective Studies', 'Sterilization, Tubal'] | 18,930,457 | [['N03.219.151.125'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.378.330', 'E01.370.388.250.360', 'E04.502.250.360', 'E04.520.360', 'E04.950.300.539'], ['Z01.542.489'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Clinicopathological study of primary malignant tumors of the lung: an analysis of 993 tumors resected at the Kanazawa University Hospital between 1979-1993. | A retrospective study was conducted of 993 malignant tumors of the lung in 977 patients. The male-female sex ratio was 2.6:1. The age distribution of the males did not differ from that of the females and the overall mean age was 64.3 +/- 9.5 years (range, 13-85 years). Forty-three percent of the patients were in their ... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Incidence', 'Japan', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Retrospective Studies', 'Sex Distribution'] | 7,823,573 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['Z01.252.474.463', '... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. | Since the introduction of new antiplatelet and anticoagulant agents in the last decade, large-scale data studying gastrointestinal bleeding (GIB) in patients undergoing percutaneous coronary intervention (PCI) are lacking. Using the Nationwide Inpatient Sample, we identified all hospitalizations from 2006 to 2012 that ... | ['Adolescent', 'Adult', 'African Americans', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Anticoagulants', 'Atrial Fibrillation', 'Comorbidity', 'Databases, Factual', 'Elective Surgical Procedures', 'Emergencies', 'European Continental Ancestry Group', 'Female', 'Gastrointestinal Diseases', 'Gastrointestinal Hemorrhage... | 27,642,112 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.502.119'], ['C14.280.067.198', 'C23.550.073.198'], ['N05.715.350.225', 'N06.850.490.687'], ['L01.313.500.750.300.188.400', 'L01.470.750.750']... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity. | Microtubules (MTs) are substrates upon which plus- and minus-end directed motors control the directional movement of cargos that are essential for generating cell polarity. Although centrosomal MTs are organized with plus-ends away from the MT organizing center, the regulation of non-centrosomal MT polarity is poorly u... | ['Animals', 'Cell Polarity', 'Cytoplasmic Vesicles', 'DNA-Binding Proteins', 'Drosophila Proteins', 'Drosophila melanogaster', 'Hair', 'LIM Domain Proteins', 'Microtubules', 'Mutation', 'Protein Isoforms', 'Wings, Animal'] | 25,005,476 | [['B01.050'], ['G04.250'], ['A11.284.430.214.190.875.190'], ['D12.776.260'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['A17.360'], ['D12.776.512'], ['A11.284.430.214.190.750.602'], ['G05.365.590'], ['D12.776.800'], ['A13.395.823']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. | BACKGROUND: Liver damage is a serious and sometimes fatal consequence of long-term alcohol intake, which progresses from early-stage fatty liver (steatosis) to later-stage steatohepatitis with inflammation and fibrosis/necrosis. However, very little is known about earlier stages of liver disruption that may occur in pr... | ['Alanine Transaminase', 'Alcohol Dehydrogenase', 'Alcohol Drinking', 'Aldehydes', 'Animals', 'Aspartate Aminotransferases', 'Binge Drinking', 'Central Nervous System Depressants', 'Cytochrome P-450 CYP2E1', 'Ethanol', 'Hepatitis, Alcoholic', 'Interleukin-1', 'Liver Function Tests', 'Male', 'Mice', 'Mice, Inbred C57BL'... | 28,103,636 | [['D08.811.913.477.700.100'], ['D08.811.682.047.820.250'], ['F01.145.317.269'], ['D02.047'], ['B01.050'], ['D08.811.913.477.700.225'], ['C25.775.100.437', 'F01.145.317.269.500', 'F03.900.100.550'], ['D27.505.696.277', 'D27.505.954.427.210'], ['D08.244.453.491.375', 'D08.811.682.662.582.338', 'D08.811.682.690.708.170.45... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tumor-promoting phorbol diesters inhibit in vitro antibody synthesis. | The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate prevents the synthesis of antibodies directed against sheep red blood cells in an in vitro system. The inhibitory effect of 3 phorbol diesters on this immune response was positively correlated with their tumor-promoting activity. The effect did not appear to be m... | ['Animals', 'Antibody Formation', 'Antibody-Producing Cells', 'Cell Differentiation', 'Cell Division', 'Cells, Cultured', 'Erythrocytes', 'Mice', 'Phorbol Esters', 'Phorbols', 'Sheep', 'Spleen', 'Tetradecanoylphorbol Acetate'] | 7,189,444 | [['B01.050'], ['G12.450.050.370.250'], ['A11.063', 'A15.382.032'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.992.635.505.500'], ['D02.455.849.291.500.510'], ['D02.455.849.291.500'], ['B... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new sensitive assay for antibody against cell surface antigens based on inhibition of cell-dependent antibody-mediated cytotoxicity. I. Specificity and sensitivity. | Inhibition of cell-dependent antibody-mediated cytotoxicity has been investigated as a new assay for antibody against cell surface antigens. The cytotoxicity system consisted of effector cells (normal mouse spleen cells), target cells ((61)Cr-labeled chicken erythrocytes), and antitarget cell antibody. Addition of anti... | ['Animals', 'Antibodies', 'Antigen-Antibody Reactions', 'Antigens', 'Antilymphocyte Serum', 'Cell Membrane', 'Chickens', 'Chromium Radioisotopes', 'Cytotoxicity Tests, Immunologic', 'Erythrocytes', 'Female', 'Immune Sera', 'Isoantibodies', 'Male', 'Mice', 'Rabbits', 'Spleen', 'T-Lymphocytes'] | 4,547,657 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.122'], ['D23.050'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114.573.203', 'D20.215.401.203'], ['A11.284.149'], ['B01.050.150.900.248.350.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. | Nerve growth factor (NGF), a member of the neurotrophin family, has been identified as an essential growth factor supporting stem cell self-renewal outside the nervous system and was previously shown to stimulate corneal epithelial proliferation both in vivo and in vitro. In this study, we evaluated the expression of N... | ['ATP Binding Cassette Transporter, Subfamily G, Member 2', 'ATP-Binding Cassette Transporters', 'Biomarkers', 'Cell Differentiation', 'Cells, Cultured', 'Epithelium, Corneal', 'Gene Expression', 'Humans', 'Limbus Corneae', 'Membrane Proteins', 'Microscopy, Confocal', 'Neoplasm Proteins', 'Nerve Growth Factor', 'RNA, M... | 17,980,361 | [['D12.776.157.530.100.228.500', 'D12.776.395.550.020.457.500', 'D12.776.543.550.192.457.500', 'D12.776.543.585.100.228.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D23.101'], ['G04.152'], ['A11.251'], ['A09.371.060.217.325', 'A10.272.510'], ['G05.297'], ['B01.0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measurement of size of pigmented choroidal nevus: Superiority of multicolor imaging compared to conventional color fundus photography. | Choroidal nevi are benign fundus lesions that require regular follow with documentation. Conventional color fundus photography (CFP) has traditionally been used to images these lesions. Multicolor imaging (MCI) available on Spectralis spectral domain optical coherence tomography system is increasingly been tested vis-?... | ['Choroid', 'Choroid Neoplasms', 'Diagnosis, Differential', 'Fluorescein Angiography', 'Fundus Oculi', 'Humans', 'Male', 'Middle Aged', 'Nevus, Pigmented', 'Photography', 'Retina', 'Tomography, Optical Coherence'] | 30,249,854 | [['A09.371.894.223'], ['C04.588.364.978.223', 'C11.319.494.198', 'C11.941.160.238', 'C11.941.855.198'], ['E01.171'], ['E01.370.370.050.350', 'E01.370.380.250'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.665.560.615'], ['E01.370.350.600', 'E05.712'], ['A09.371.7... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The amount and distribution of sclerotic human root dentine. | In low-power photomicrographs of ground sections of canine teeth, the amount of sclerosis increased with age linearly and was not markedly affected by the function of the tooth or external stimuli encountered during life. The pattern of distribution was similar in all teeth. Sclerosis started in the apical dentine adja... | ['Adolescent', 'Adult', 'Aged', 'Aging', 'Cuspid', 'Dentin', 'Humans', 'Middle Aged', 'Sclerosis', 'Tooth Root'] | 6,579,896 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['A14.549.167.860.200'], ['A14.549.167.900.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.823'], ['A14.549.167.900.750']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice. | BACKGROUND: Currently, combined therapy using herbs and synthetic drugs has become a feasible therapeutic intervention against some diseases. The purpose of this study was to assess the effects of supplementation with fenofibrate (FF), a chemical drug used for the treatment of hyperlipidemia, and the aqueous extract of... | ['Animals', 'Combined Modality Therapy', 'Dietary Supplements', 'Dose-Response Relationship, Drug', 'Drugs, Chinese Herbal', 'Fenofibrate', 'Glucose', 'Hypercholesterolemia', 'Lipids', 'Liver', 'Liver Function Tests', 'Male', 'Mice', 'Mice, Inbred ICR', 'Schisandra'] | 25,733,812 | [['B01.050'], ['E02.186'], ['G07.203.300.456', 'J02.500.456'], ['G07.690.773.875', 'G07.690.936.500'], ['D20.215.784.500.350', 'D26.335'], ['D02.241.081.114.968.500.625', 'D02.355.726.305.625', 'D02.455.426.559.389.134.750', 'D02.455.426.559.389.657.654.305.625', 'D02.522.223.750'], ['D09.947.875.359.448'], ['C18.452.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Mutant of phi X174 accessible to host-controlled modification. | A proflavine-induced phiX174 mutant was isolated, phiX174 sB1, which is accessible to restriction and modification by B-host specificity, but not by K-host specificity. | ['Acridines', 'Coliphages', 'Escherichia coli', 'Genetics, Microbial', 'Hybridization, Genetic', 'Mutation', 'Selection, Genetic'] | 4,891,753 | [['D03.633.300.046'], ['B04.123.205'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['H01.158.273.343.330', 'H01.158.273.540.367'], ['E05.820.150.390', 'G05.090.390'], ['G05.365.590'], ['G05.783']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal serum inhibin A can predict pre-eclampsia. | OBJECTIVE: To compare median levels of maternal serum inhibin A in the second trimester blood samples of women who subsequently develop pre-eclampsia and those who do not.DESIGN: Retrospective analysis of 13 18 week samples from a bank of serum stored at -40 degrees C, originally taken for Down's syndrome screening.SET... | ['Biomarkers', 'Female', 'Humans', 'Inhibins', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Trimester, Second', 'Prenatal Diagnosis', 'Retrospective Studies'] | 9,800,934 | [['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.334.968', 'D06.472.699.337', 'D12.644.548.387', 'D12.776.395.439'], ['C13.703.395.249'], ['G08.686.784.769'], ['G08.686.707.490'], ['E01.370.378.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Preliminary analysis of short-term financial implications of a prevention bonus program: first results from the German Statutory Health Insurance. | OBJECTIVES: With the implementation of the Health Care Modernization Act in 2004 sickness funds in Germany were given the opportunity to award bonuses to their insured for health-promoting behavior. The aim of this study was to investigate the financial implications of a prevention bonus program from a sickness fund pe... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Chronic Disease', 'Cohort Studies', 'Cost Savings', 'Female', 'Germany', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Health Promotion', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mass Screening', 'Middle Aged', 'Motivation', 'National H... | 18,681,336 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.151.160.200'], ['Z01.542.315'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'], ['I02.233.332.445', 'N02.42... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
C-terminus of a long alpha-neurotoxin is highly mobile when bound to the nicotinic acetylcholine receptor: a time-resolved fluorescence anisotropy approach. | To better understand how alpha-neurotoxins interact with the acetylcholine receptor, four fluorescein isothiocyanate derivatives of the siamemsis alpha-cobratoxin were prepared (conjugated to the epsilon-amino group in Lys(23), Lys(35), Lys(49), or Lys(69)) and the time-resolved fluorescence anisotropy of each conjugat... | ['Animals', 'Elapidae', 'Fluorescein-5-isothiocyanate', 'Fluorescence Polarization', 'Movement', 'Neurotoxins', 'Protein Binding', 'Receptors, Nicotinic', 'Time Factors', 'Torpedo'] | 15,894,420 | [['B01.050'], ['B01.050.150.900.833.672.125.875'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275.400', 'D04.711.347.400'], ['E05.196.712.516.600.390'], ['G07.568', 'G11.427.410'], ['D27.888.569.504'], ['G02.111.679', 'G03.808'], ['D12.776.157.530.400.400.100.500', 'D12.776.543.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Opposing effects of phosphoenolpyruvate and pyruvate with Mg(2+) on the conformational stability and dimerization of phosphotransferase enzyme I from Escherichia coli. | The activity of enzyme I (EI), the first protein in the bacterial PEP:sugar phosphotransferase system, is regulated by a monomer-dimer equilibrium where a Mg(2+)-dependent autophosphorylation by PEP requires the homodimer. Using inactive EI(H189A), in which alanine is substituted for the active-site His189, substrate-b... | ['Binding Sites', 'Calorimetry, Differential Scanning', 'Dimerization', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Magnesium', 'Phosphoenolpyruvate', 'Phosphorylation', 'Phosphotransferases', 'Protein Conformation', 'Protein Structure, Tertiary', 'Pyruvic Acid', 'Spectrometry, Fluorescence', 'Substrate Specific... | 12,931,002 | [['G02.111.570.120'], ['E05.196.131.310', 'E05.196.370.310'], ['G02.206', 'G03.230'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D02.241.511.701'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D08.811.913.696'], ['G02.111.570.820.709... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Resident Medical Officer working conditions in New Zealand: results of a recent survey. | AIMS: To survey Resident Medical Officers (RMOs) and Senior Medical Officers (SMOs) working at Auckland District Health Board (ADHB) on various aspects of RMO-working conditions and to trial the use of electronic keypad responders for this purpose.METHODS: In April 2004, the Physicians Grand Round at ADHB was used as a... | ['Contracts', 'Data Collection', 'Hospital Administration', 'Hospitals', 'Job Satisfaction', 'Medical Staff, Hospital', 'New Zealand', 'Personnel Staffing and Scheduling', 'State Medicine', 'Workforce', 'Workload'] | 15,505,665 | [['I01.880.604.583.090', 'N03.706.535.241'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['N02.278.421'], ['F02.784.692.425'], ['M01.526.485.630.490', 'M01.526.485.740.422', 'N02.360.630.490', 'N02.360.740.422'], ['Z01.639.760.747', 'Z01.678.1... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Two methods for fitting a rectangular hyperbola to data from several animals. | Two methods are described for fitting the Michaelis-Menten equation to sets of data with a common michaelis constant but different maximum velocities. One of them uses the method of least squares, and the other is based on the direct plot of Eisenthal & Cornish-Bowden [Biochem. J. (1974) 139, 715-720]. | ['Animals', 'Enzymes', 'Kinetics', 'Statistics as Topic'] | 962,878 | [['B01.050'], ['D08.811'], ['G01.374.661', 'G02.111.490'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Consumer evaluation of a mental health liaison nurse service in the Emergency Department. | The mainstreaming of mental health services into the general healthcare system has added to the demands placed on Emergency Departments (EDs) in terms of the assessment, management and disposition of mental health related presentations. There is a growing body of research that highlights the difficulties encountered by... | ['Adult', 'Aged', 'Aged, 80 and over', 'Emergency Service, Hospital', 'Emergency Services, Psychiatric', 'Feedback', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'New South Wales', "Nurse's Role", 'Nursing Evaluation Research', 'Patient Satisfaction', 'Referral and Consultation'] | 16,594,877 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['F04.408.525', 'N02.421.297.200'], ['L01.906.394.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['Z01.639.100.750', 'Z01.678.100.373.750'], [... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Immunoglobulins on the surface of lymphoid cells in Waldenstr?m's macroglobulinemia. | Immunofluorescence study of viable and fixed cells was performed on marrow and blood samples from 25 patients with Waldenstr?m's macroglobulinemia. Whereas intracytoplasmic staining for IgM was restricted to the plasma cells and to a limited number of lymphocytic cells, the vast majority of the pleomorphic "lymphoid" p... | ['Bone Marrow', 'Bone Marrow Cells', 'Cell Differentiation', 'Cell Membrane', 'Clone Cells', 'Cytoplasm', 'Fluoresceins', 'Fluorescent Antibody Technique', 'Humans', 'Immune Sera', 'Immunoglobulin M', 'Lymphocytes', 'Microscopy, Fluorescence', 'Microscopy, Phase-Contrast', 'Mitosis', 'Plasma Cells', 'Waldenstrom Macrog... | 4,622,108 | [['A15.382.216'], ['A11.148', 'A15.378.316'], ['G04.152'], ['A11.284.149'], ['A11.251.353'], ['A11.284.430.214'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
On the interaction of the finger and the kringle-2 domain of tissue-type plasminogen activator with fibrin. Inhibition of kringle-2 binding to fibrin by epsilon-amino caproic acid. | The binding of tissue-type plasminogen activator (t-PA) to fibrin is mediated both by its finger domain and by its kringle-2 domain. In this report, we investigate the relative affinities of these domains for lysine. Human recombinant t-PA deletion-mutant proteins were prepared and their ability to bind to lysine-Sepha... | ['Aminocaproates', 'Aminocaproic Acid', 'Animals', 'Binding Sites', 'Chromatography, Affinity', 'Fibrin', 'Humans', 'Lysine', 'Mice', 'Peptide Fragments', 'Protein Conformation', 'Recombinant Proteins', 'Tissue Plasminogen Activator'] | 3,021,732 | [['D02.241.081.193.150', 'D12.125.213'], ['D02.241.081.193.150.075', 'D12.125.213.075'], ['B01.050'], ['G02.111.570.120'], ['E05.196.181.400.170'], ['D12.776.124.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['B01.050.150.900.649.313.992.635.505.500']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Using both principal component analysis and reduced rank regression to study dietary patterns and diabetes in Chinese adults. | OBJECTIVE: We examined the association between dietary patterns and diabetes using the strengths of two methods: principal component analysis (PCA) to identify the eating patterns of the population and reduced rank regression (RRR) to derive a pattern that explains the variation in glycated Hb (HbA1c), homeostasis mode... | ['Adult', 'Blood Glucose', 'China', 'Diabetes Mellitus', 'Diet', 'Family Characteristics', 'Feeding Behavior', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Insulin Resistance', 'Male', 'Middle Aged', 'Nutrition Surveys', 'Odds Ratio', 'Principal Component Analysis', 'Research Design'] | 26,784,586 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['Z01.252.474.164'], ['C18.452.394.750', 'C19.246'], ['G07.203.650.240'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['D09.400.430.937', 'D12.776.124... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]',... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
DNA torsional dynamics by multifrequency phase fluorometry. | The time decay of the fluorescence polarization anisotropy of calf thymus DNA-ethidium complexes is obtained from measurements with sine-modulated excitation employing the so-called multifrequency phase fluorometry. A torsional dynamics model developed by J. M. Schurr [(1984) Chemical Physics, Vol. 84, pp. 71-96] and t... | ['Animals', 'Cattle', 'DNA', 'Fluorometry', 'Thermodynamics'] | 1,457,726 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D13.444.308'], ['E05.196.712.516.600'], ['G01.906']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Seizures in infancy in the offspring of women with epilepsy. | OBJECTIVES: To assess (a) the incidence of seizures in the first year of life in infants born to mothers with epilepsy and (b) factors that might contribute to the seizure incidence.MATERIALS & METHODS: Analysis of data collected in the Australian Register of Antiepileptic Drugs in Pregnancy during and at the end of th... | ['Adult', 'Australia', 'Epilepsy', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Pregnancy', 'Pregnancy Complications', 'Seizures'] | 31,532,859 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614'], ['G08.686.784.769'], ['C13.703'], ['C10.597.742', 'C23.888.592.742']] | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Amitriptyline in the treatment of thalamic pain. | Two patients had chronic pain and involuntary movements after thalamic infarction. Amitriptyline, but not conventional analgesics, provided permanent relief from disabling pain. | ['Adult', 'Aged', 'Amitriptyline', 'Female', 'Humans', 'Male', 'Pain, Intractable', 'Thalamic Diseases'] | 3,715,541 | [['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.847.181.384.100', 'D04.615.181.384.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.776'], ['C10.228.140.915']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of abdominoplasty on respiratory functions: a prospective study. | The short-term and the long-term effects of abdominoplasty on the respiratory function of healthy adults are not known because of a lack of studies on this subject. Theoretically one might suggest that abdominoplasty can cause respiratory decompensation resulting from musculofascial plication, which reduces the respira... | ['Abdomen', 'Adult', 'Body Mass Index', 'Female', 'Humans', 'Middle Aged', 'Prospective Studies', 'Respiratory Function Tests', 'Respiratory Mechanics', 'Statistics, Nonparametric', 'Treatment Outcome'] | 12,461,445 | [['A01.923.047'], ['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.386.700'], ['G09.772... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. | OBJECTIVE: Activation of collagen receptors expressed by smooth muscle cells induces matrix metalloproteinase (MMP) expression. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediated MMP expression ha... | ['Cells, Cultured', 'Collagen', 'Gene Expression', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Infant, Newborn', 'Leucine', 'Matrix Metalloproteinase 1', 'Matrix Metalloproteinase Inhibitors', 'Mevalonic Acid', 'Muscle, Smooth, Vascular', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Signal Transduct... | 17,303,772 | [['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954.557.500.202.370'], ['M01.060.703.520'], ['D12.125.070.637', 'D12.125.142.441'], ['D08.811.277.656.300.480.205.351', 'D08.811.277.656... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
State-specific rates of mental retardation--United States, 1993. | Mental retardation (MR) is the most common developmental disability and ranks first among chronic conditions causing major activity limitations among persons in the United States (1). National and state-specific surveillance to measure the prevalence of MR can assist in targeting areas of need and allocating resources.... | ['Adolescent', 'Adult', 'Age Distribution', 'Child', 'Humans', 'Intellectual Disability', 'Linear Models', 'Middle Aged', 'Population Surveillance', 'Socioeconomic Factors', 'United States', 'United States Social Security Administration'] | 8,544,809 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. | We investigated the role of the protein phosphatase inhibitor, dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), in the expression of striatal neuropeptides and in biochemical and behavioural responses to repeated cocaine administration, using DARPP-32 knock-out mice. The striatum of DARPP-32-mutant mic... | ['Animals', 'Behavior, Animal', 'Cocaine', 'Cocaine-Related Disorders', 'Corpus Striatum', 'Dopamine Uptake Inhibitors', 'Dopamine and cAMP-Regulated Phosphoprotein 32', 'Enzyme Inhibitors', 'Gene Expression', 'Locomotion', 'Male', 'Mice', 'Mice, Mutant Strains', 'Nerve Tissue Proteins', 'Neurons', 'Phosphoproteins', '... | 10,103,106 | [['B01.050'], ['F01.145.113'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C25.775.300', 'F03.900.300'], ['A08.186.211.200.885.287.249.487'], ['D27.505.519.562.437.220', 'D27.505.519.625.150.800', 'D27.505.519.625.600.220', 'D27.505.696.577.150.800', 'D27.505.696.577.600.... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surgical resection of solitary metastasis of malignant melanoma to the right atrium. | Malignant melanoma has a very high tendency to metastasize to the heart. Although most cardiac metastases of melanomas are clinically silent, the lesions may present with life-threatening cardiac morbidities, including dysrhythmia, right ventricular outflow tract obstruction, myocardial dysfunction, pericardial effusio... | ['Adult', 'Cardiac Surgical Procedures', 'Chemotherapy, Adjuvant', 'Echocardiography', 'Heart Atria', 'Heart Neoplasms', 'Humans', 'Male', 'Melanoma', 'Neoplasms, Unknown Primary', 'Treatment Outcome'] | 20,978,580 | [['M01.060.116'], ['E04.100.376', 'E04.928.220'], ['E02.186.170', 'E02.319.170'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541.358'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A semi-empirical study of some clavulanic acid derivatives in relation to their activity as beta-lactamase inhibitors. | Clavulanic acid and some of its derivatives are inhibitors of beta-lactamases and hence enhance the activity of antibiotics such as cephaloridine, amoxycillin and ampicillin against beta-lactamase-producing bacteria. Several empirical structure-activity relationships have been proposed for these compounds; bearing thes... | ['Clavulanic Acids', 'Molecular Conformation', 'Structure-Activity Relationship', 'beta-Lactamase Inhibitors'] | 8,094,441 | [['D02.065.589.099.374', 'D03.633.100.300.374'], ['G02.111.570.820'], ['G02.111.830', 'G07.690.773.997'], ['D27.505.519.389.400', 'D27.505.954.122.085.516']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxidative stress in painters exposed to low lead levels. | Lead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and commercial painters of Luck... | ['Adult', 'Antioxidants', 'Humans', 'Lead', 'Lead Poisoning', 'Lipid Peroxidation', 'Male', 'Middle Aged', 'Occupational Diseases', 'Occupational Exposure', 'Oxidative Stress', 'Thiobarbituric Acid Reactive Substances'] | 18,796,383 | [['M01.060.116'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['C25.723.522.750'], ['G02.111.515', 'G03.295.531.587'], ['M01.060.116.630'], ['C24'], ['N06.850.460.350.600'], ['G03.673', 'G07.775.750'], ['D02.047.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pattern evoked potential diagnosis of multiple sclerosis: a comparison of various contrast stimuli. | 1. The transient and steady-state reversals seem to give equivalent information. 2. Random presentation of pattern reversals evokes the same response as conventional repetitive stimulation. Since random stimulation abolishes rhythmic activity, it is the most efficient stimulus form to generate a reversal response. 3. T... | ['Diagnosis, Differential', 'Evoked Potentials, Visual', 'Humans', 'Multiple Sclerosis', 'Pain', 'Photic Stimulation', 'Reference Values'] | 7,054,965 | [['E01.171'], ['G07.265.216.500.425', 'G11.561.200.500.425', 'G14.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E05.723.729'], ['E05.978.810']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Elevated S100A8 protein expression in breast cancer cells and breast tumor stroma is prognostic of poor disease outcome. | PURPOSE: Elevated S100A8 expression has been observed in cancers of the bladder, esophagus, colon, ovary, and breast. S100A8 is expressed by breast cancer cells as well as by infiltrating immune and myeloid cells. Here we investigate the association of elevated S100A8 protein expression in breast cancer cells and in br... | ['Biomarkers, Tumor', 'Breast Neoplasms', 'Calgranulin A', 'Cancer-Associated Fibroblasts', 'Female', 'Fluorescent Antibody Technique', 'Humans', 'Kaplan-Meier Estimate', 'Neoplasm Grading', 'Neoplasm Staging', 'Prognosis', 'Proportional Hazards Models', 'Receptors, Estrogen', 'Stromal Cells', 'Tissue Array Analysis', ... | 28,717,852 | [['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['D12.776.157.125.750.500.100', 'D12.776.631.655.500.100', 'D23.050.301.562.100'], ['A11.329.228.105'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The significance of secretory features and coincident hyperplastic changes in endometrial biopsy specimens. | The clinical and pathological characteristics of endometrial hyperplasia simulating or coexisting with secretory endometrium were studied in 35 cases of women with at least one biopsy diagnosed as secretory endometrium and another biopsy diagnosed as endometrial hyperplasia or neoplasia. The biopsy samples were examine... | ['Adult', 'Endometrial Hyperplasia', 'Endometrium', 'Female', 'Humans'] | 3,610,133 | [['M01.060.116'], ['C13.351.500.852.228'], ['A05.360.319.679.490'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Pathophysiological study of the ileum after total colectomy in combination with mucosal proctectomy and ileoanostomy--the alteration in water and electrolyte absorption by the ileum after ileoanostomy]. | We have developed a new procedure, total colectomy in combination with mucosal proctectomy and ileoanostomy, to preserve anorectal function for the patients with adenomatosis coli and ulcerative colitis. Using dialysis method, we evaluated the alteration of the ability to absorb water and electrolytes at the ileum afte... | ['Adolescent', 'Adult', 'Anal Canal', 'Animals', 'Body Water', 'Child', 'Colectomy', 'Dogs', 'Electrolytes', 'Female', 'Humans', 'Ileum', 'Intestinal Absorption', 'Intestinal Mucosa', 'Male', 'Methods', 'Middle Aged', 'Postoperative Period', 'Rectum'] | 6,503,952 | [['M01.060.057'], ['M01.060.116'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['B01.050'], ['A12.207.200'], ['M01.060.406'], ['E04.210.219'], ['B01.050.150.900.649.313.750.250.216.200'], ['D01.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['G03.015.500.374.500'... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distribution of virulence factors in ESBL-producing Escherichia coli isolated from the environment, livestock, food and humans. | In this study, extended-spectrum ?-lactamase (ESBL)-producing Escherichia coli isolates recovered from the following sources were characterized with regard to the occurrence and distribution of uropathogenic and enteric pathogenic virulence factors: surface waters (rivers and lakes, n=60), the intestines of freshwater ... | ['Animals', 'Environmental Microbiology', 'Environmental Monitoring', 'Escherichia coli', 'Humans', 'Livestock', 'Multilocus Sequence Typing', 'Phylogeny', 'Swine', 'Virulence Factors', 'beta-Lactamases'] | 26,437,344 | [['B01.050'], ['H01.158.273.540.274', 'N06.850.425'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.050.116.500'], ['E01.370.225.875.150.125.457.500', 'E05.200.875.150.125.457.500', 'E05.393.542.500', 'E05.3... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Raltegravir with optimized background therapy for resistant HIV-1 infection. | BACKGROUND: Raltegravir (MK-0518) is an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase active against HIV-1 susceptible or resistant to older antiretroviral drugs.METHODS: We conducted two identical trials in different geographic regions to evaluate the safety and efficacy of raltegravir, as compare... | ['Adolescent', 'Adult', 'Aged', 'CD4 Lymphocyte Count', 'Double-Blind Method', 'Drug Resistance, Viral', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'HIV Infections', 'HIV Integrase Inhibitors', 'HIV-1', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Neoplasms', 'Organic Chemicals', 'Pyrrolidinone... | 18,650,512 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['E05.318.370.300', 'E05.581.500.300'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Performance status is the most powerful risk factor for early death among patients with advanced soft tissue sarcoma: the European Organisation for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (STBSG) and French Sarcoma Group (FSG) study. | BACKGROUND: We investigated prognostic factors (PFs) for 90-day mortality in a large cohort of advanced/metastatic soft tissue sarcoma (STS) patients treated with first-line chemotherapy.METHODS: The PFs were identified by both logistic regression analysis and probability tree analysis in patients captured in the Soft ... | ['Adult', 'Cohort Studies', 'Europe', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Risk Factors', 'Sarcoma', 'Soft Tissue Neoplasms', 'Treatment Outcome'] | 21,505,457 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Depressive symptoms in climacteric women are related to menopausal symptom intensity and partner factors. | OBJECTIVE: To determine the prevalence of depressive symptoms and associated risk factors among climacteric women.METHODS: In this cross-sectional study, women aged 40-59 years, visiting inpatients at the Enrique C. Sotomayor Obstetrics and Gynecology Hospital, Guayaquil, Ecuador, were surveyed with the 17-item Hamilto... | ['Adult', 'Alcoholism', 'Depression', 'Educational Status', 'Erectile Dysfunction', 'Female', 'Humans', 'Logistic Models', 'Male', 'Menopause', 'Middle Aged', 'Spouses', 'Surveys and Questionnaires'] | 19,387,879 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['F01.145.126.350'], ['N01.824.196'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.62... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Business mergers and acquisitions and the risk of mental disorders: a population-based study. | OBJECTIVES: Mergers and acquisitions (M&A) activities are increasing and may negatively affect workers mental health. However, the impact of M&A on the risk of developing a mental disorder, rather than psychiatric symptoms, has not been investigated. The objectives of this study were to estimate and compare the 12-mont... | ['Adult', 'Anxiety Disorders', 'Commerce', 'Depressive Disorder, Major', 'Employment', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Occupational Diseases', 'Occupations', 'Prevalence', 'Risk Factors', 'Work'] | 22,228,854 | [['M01.060.116'], ['F03.080'], ['J01.219'], ['F03.600.300.375'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['C24'], ['N01.824.547'], ['E05.318.308.985.525.750', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Effect of growth conditions on the content of the major groups of carbohydrates in chick embryo fibroblasts. | The levels of glycogen, hyaluronic acid, chondroitin sulfates, N-acetylneuraminic acid, all of the monosaccharide components of the glycoprotein and glycolipid fractions, and the monosaccharide pools were measured in cultured chick embryo fibroblasts. Under all growth conditions, the glycogen plus the glucose phosphate... | ['Animals', 'Avian Sarcoma Viruses', 'Carbohydrate Metabolism', 'Cell Division', 'Cell Transformation, Viral', 'Cells, Cultured', 'Chick Embryo', 'Chondroitin Sulfates', 'Fibroblasts', 'Glycogen', 'Hot Temperature', 'Hyaluronic Acid', 'Monosaccharides', 'Sialic Acids'] | 221,107 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evolutionary steps of sex chromosomes are reflected in retrogenes. | It has been shown that selective pressure to compensate for the silencing of the sex chromosomes during male meiosis resulted in many X-linked genes being duplicated as functional retrogenes on autosomes. The silencing of male sex chromosomes was probably stratified during evolution, in accordance with their stratified... | ['Animals', 'Evolution, Molecular', 'Genes, X-Linked', 'Humans', 'Mammals', 'Models, Biological', 'Phylogeny', 'Retroelements', 'Sex Chromosomes'] | 18,774,619 | [['B01.050'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.500', 'G05.420.457'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649'], ['E05.599.395'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.308.760', 'G02.111.570.080.708.330.800', 'G05.360.080.708.330.800', 'G05.360.340.024.4... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of three different fat graft preparation methods: gravity separation, centrifugation, and simultaneous washing with filtration in a closed system. | BACKGROUND: Successful long-term volume retention of an autologous fat graft is problematic. The presence of contaminating cells, tumescent fluid, and free lipid in the graft contributes to disparate outcomes. Better preparation methods for the fat graft before transplantation may significantly improve results.METHODS:... | ['Adult', 'Centrifugation', 'Female', 'Filtration', 'Gravitation', 'Humans', 'Middle Aged', 'Subcutaneous Fat', 'Tissue and Organ Harvesting', 'Young Adult'] | 23,542,259 | [['M01.060.116'], ['E05.181'], ['E05.196.454', 'G01.280', 'G02.263'], ['G01.060.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A10.165.114.830.750'], ['E04.936.537'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The psychological effect of clinical examination on women with tubal infertility]. | OBJECTIVE: To comprehend the psychological effects in the course of diagnosis and treatment of infertility on the sexuality, emotional feeling and marriage of women with tubal infertility.METHODS: The study involved 180 hospitalized patients who were awaiting tube operation from May to September in the year 2000. A sur... | ['Adult', 'Fallopian Tube Diseases', 'Female', 'Humans', 'Infertility, Female', 'Salpingitis', 'Sexual Behavior', 'Surveys and Questionnaires'] | 12,600,100 | [['M01.060.116'], ['C13.351.500.056.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['C13.351.500.056.390.890', 'C13.351.500.056.750.875'], ['F01.145.802'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bioptic telescopes meet the needs of drivers with moderate visual acuity loss. | PURPOSE: Visually impaired people are permitted to use bioptic telescopes for driving in many states in the United States. However, it has been suggested that the telescope is used only to meet the visual acuity criteria for licensure. In this study, a survey was used to establish the extent to which bioptic telescopes... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Automobile Driving', 'Cross-Sectional Studies', 'Eyeglasses', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sensory Aids', 'Surveys and Questionnaires', 'United States', 'Vision, Low', 'Visual Acuity', 'Visually Impaired Persons'] | 15,623,756 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I03.125'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E07.632.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E07.814'], ['E05.318.308.980', 'N05.715.360.300.800', ... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Three new triterpenoid saponins from Dianthus superbus. | Three new triterpenoid saponins (1-3) were isolated from the dried aerial parts of Dianthus superbus L. (Caryophyllaceae). Their structures were established as 3-O-â-D-glucopyranosyl gypsogenic acid 28-O-[â-D-6-O-((3S)-3-hydroxyl-3-methylglutaryl)glucopyranosyl(1?6)]-â-D-glucopyranoside (1), 3-O-â-D-glucopyranosyl gyps... | ['Dianthus', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Saponins', 'Triterpenes'] | 21,467,688 | [['B01.650.940.800.575.912.250.198.500.250.222'], ['E05.196.867.519'], ['G02.111.570.820'], ['D09.408.782'], ['D02.455.849.919']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of coronary atherosclerosis in middle-aged Norwegian and Japanese men. An autopsy study. | We compared the extent of lesions in the coronary arteries of autopsied middle-aged men from Oslo, Norway, with lesions in autopsied men of similar ages in Tokyo, Japan. Certain risk factors for coronary heart disease as serum cholesterol, triglycerides, and blood pressure were also available from these men in the two ... | ['Adult', 'Blood Pressure', 'Cholesterol', 'Coronary Artery Disease', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Norway', 'Risk', 'Triglycerides'] | 3,560,868 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['Z01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Detection of human androgen receptor mRNA expression abnormalities by competitive PCR. | A competitive polymerase chain reaction (PCR) method for analysis of androgen receptor (AR) mRNA expression is described. The technique involves the use of an in vitro-transcribed RNA (cRNA) corresponding to a region of the AR mRNA transcript as a competitor in reverse transcription and PCR (RT-PCR) using total cellula... | ['Base Sequence', 'Cells, Cultured', 'DNA', 'DNA Primers', 'Down-Regulation', 'Fibroblasts', 'Gene Expression', 'Humans', 'Hypospadias', 'Infant', 'Infant, Newborn', 'Kinetics', 'Male', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'RN... | 7,909,666 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['D13.444.308'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.329.228'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494.400', 'C12.706.516', 'C13.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Assessment of epidemiologic capacity in state and territorial health departments--United States, 2004. | In November 2001, the Council of State and Territorial Epidemiologists (CSTE) conducted a survey of state and territorial health departments to assess their core epidemiologic capacity. The survey was completed just before distribution of approximately $1 billion in terrorism preparedness and emergency response funds i... | ['Epidemiology', 'Public Health Administration', 'United States', 'Workforce'] | 15,889,007 | [['H02.403.720.500'], ['N04.452.794'], ['Z01.107.567.875'], ['N04.452.525']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Characterization of capsaicin-sensitive neurones in adult rat dorsal root ganglion cultures. | Two populations of neurones can be distinguished in sections of dorsal root ganglia (DRG) by light microscopy and immunofluorescence techniques: large light (neurofilament-positive) and small dark (neurofilament-negative) neurones. This paper shows that corresponding populations can be seen in cultures of adult rat DRG... | ['Animals', 'Antibodies, Monoclonal', 'Capsaicin', 'Cells, Cultured', 'Cobalt', 'Ganglia, Spinal', 'Immunohistochemistry', 'Intermediate Filament Proteins', 'Neurofilament Proteins', 'Neurons', 'Neurotoxins', 'Rats', 'Rats, Inbred Strains'] | 3,120,057 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.355.325.190'], ['A11.251'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['A08.340.390.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Access to Dental Services for People Using a Wheelchair. | OBJECTIVES: We investigated the perspectives of people using a wheelchair and their difficulties in accessing dental services.METHODS: Our participatory research was on the basis of a partnership between people using a wheelchair, dental professionals, and academic researchers. Partners were involved in a committee tha... | ['Adolescent', 'Adult', 'Aged', 'Architectural Accessibility', 'Dental Care', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Oral Health', 'Qualitative Research', 'Quebec', 'Transportation', 'Wheelchairs', 'Young Adult'] | 26,378,836 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['J01.086.339.070'], ['E06.170', 'N02.421.240.190'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N01.400.535'], ['H01.770.644.241.850'], ['Z01.107.567.176.791'], ['J01.937'], ['E07.796.980'], ['M01.06... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Sequence analysis and expression of the human parainfluenza type 1 virus nucleoprotein gene. | The nucleotide sequence of the human parainfluenza type 1 (Pl1) virus nucleoprotein (NP) gene was determined from cDNA clones of the mRNA. A cDNA clone, 4-31, containing a 1.7-kb insert, was identified as a Pl1 NP-specific clone by partial nucleotide sequence analysis and sequence comparison with Sendai virus (SV) NP. ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'Cloning, Molecular', 'DNA, Viral', 'Genes, Viral', 'Humans', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Nucleoproteins', 'Oligonucleotide Probes', 'Parainfluenza Virus 1, Human', 'RNA, Messenger', 'Sequence Homology, Nucleic Acid', 'Transf... | 1,847,263 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['E05.393.220'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.24... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Full-Contour Zirconia Fixed Partial Dentures as Chairside Applications: A Case Report. | Clinical application of zirconia has been expanding due to the high strength properties it offers. Initial use of zirconia was as a coping or substructure material replacing cast metal. More recent formulations have been introduced for monolithic zirconia contour designs. New chairside computer-aided design and compute... | ['Computer-Aided Design', 'Dental Materials', 'Dental Prosthesis Design', 'Denture, Partial, Fixed', 'Humans', 'Male', 'Middle Aged', 'Tooth Fractures', 'Tooth Root', 'Zirconium'] | 27,700,133 | [['L01.224.108.150', 'L01.296.110.150'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['E06.780.346.625', 'E06.912.145'], ['E06.780.346.760.943.271', 'E07.695.190.200.220.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C07.793.850.750', 'C26.900.750'], ['A14.549.167.900.750'], ['D01... | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Prone ventilation in trauma or surgical patients with acute lung injury and adult respiratory distress syndrome: is it beneficial? | BACKGROUND: To compare the effectiveness of supine versus prone kinetic therapy in mechanically ventilated trauma and surgical patients with acute lung injury (ALI) and adult respiratory distress syndrome (ARDS).METHODS: A retrospective review of all patients with ALI/ARDS who were placed on either a supine (roto-rest)... | ['Adult', 'Beds', 'Humans', 'Kinetics', 'Middle Aged', 'Prone Position', 'Respiration, Artificial', 'Respiratory Distress Syndrome', 'Retrospective Studies', 'Supine Position', 'Surgical Procedures, Operative', 'Treatment Outcome', 'Wounds and Injuries'] | 17,495,725 | [['M01.060.116'], ['E07.325.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['M01.060.116.630'], ['G11.427.695.525'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['C08.381.840', 'C08.618.840'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of magnesium ions on oriented growth of calcite on carboxylic acid functionalized self-assembled monolayer. | The combined effect of templating and solution additives on calcite crystallization was studied. Self-assembled monolayers of mercaptoundecanoic acid supported on silver, as templates, induced the uniform, oriented nucleation of calcite from the (012) plane. The presence of Mg2+ in the crystallizing solution affected t... | ['Biomimetic Materials', 'Calcium Carbonate', 'Carboxylic Acids', 'Crystallization', 'Magnesium', 'Microscopy, Electron, Scanning'] | 12,670,208 | [['J01.637.087'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['D02.241'], ['E05.196.300', 'G02.171'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['E01.370.350.515.402.541', 'E05.595.402.541']] | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparative effect of angiotensin II, potassium, adrenocorticotropin, and cyclic adenosine 3',5'-monophosphate on cytosolic calcium in rat adrenal cells. | The present study compares changes in cytosolic calcium and steroidogenesis when rat adrenal cells are stimulated with potassium (K+), angiotensin II (AII), ACTH, and (Bu)2cAMP (cAMP). The calcium-sensitive fluorescent dye, quin 2, was used to determine cytosolic calcium concentrations. K+ and AII both induced parallel... | ['Adrenal Glands', 'Adrenocorticotropic Hormone', 'Aminoquinolines', 'Angiotensin II', 'Animals', 'Bucladesine', 'Calcium', 'Cyclic AMP', 'Cytosol', 'Dantrolene', 'Fluorescent Dyes', 'Gallic Acid', 'Nifedipine', 'Potassium', 'Rats'] | 3,015,562 | [['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['D03.633.100.810.050'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.64... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein-RNA Dynamics in the Central Junction Control 30S Ribosome Assembly. | Interactions between ribosomal proteins (rproteins) and ribosomal RNA (rRNA) facilitate the formation of functional ribosomes. S15 is a central domain primary binding protein that has been shown to trigger a cascade of conformational changes in 16S rRNA, forming the functional structure of the central domain. Previous ... | ['DNA Mutational Analysis', 'Escherichia coli', 'Fluorescence Resonance Energy Transfer', 'Genetic Complementation Test', 'Macromolecular Substances', 'Magnesium', 'Models, Biological', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Protein Interaction Maps', 'RNA, Ribosomal, 16S', 'Ribosomal Proteins... | 27,192,112 | [['E05.393.760.700.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['E05.393.281.526'], ['D05'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['E05.599.395'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.82... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamics of capillary electrochromatography experimental study on the electrosmotic flow and conductance in open and packed capillaries. | For capillary electrochromatography (CEC) to become an analytical separation technique of high speed and resolution the factors determining the conductivity of the column as well as the generation and control of electrosmotic flow (EOF) in porous media have to be understood. In the present study the conductance of capi... | ['Acetonitriles', 'Chromatography, High Pressure Liquid', 'Electric Conductivity', 'Electrophoresis, Capillary', 'Hydrocarbons, Aromatic', 'Ion Exchange Resins', 'Microspheres', 'Models, Chemical', 'Osmosis', 'Particle Size', 'Permeability', 'Polystyrenes', 'Salts', 'Silicon Dioxide'] | 9,368,384 | [['D02.626.080'], ['E05.196.181.400.300'], ['G01.358.500.249.277'], ['E05.196.401.190', 'E05.301.300.190'], ['D02.455.426.559'], ['D27.720.470.420'], ['E07.565'], ['E05.599.495'], ['G01.154.090.750', 'G02.111.655', 'G02.691', 'G02.723.495'], ['G02.712'], ['G02.723'], ['D02.455.426.559.389.150.750.800.830', 'D05.750.716... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Colonization and osteogenic differentiation of different stem cell sources on electrospun nanofiber meshes. | Numerous challenges remain in the successful clinical translation of cell-based therapies for musculoskeletal tissue repair, including the identification of an appropriate cell source and a viable cell delivery system. The aim of this study was to investigate the attachment, colonization, and osteogenic differentiation... | ['Alkaline Phosphatase', 'Amniotic Fluid', 'Calcium', 'Cell Differentiation', 'Cell Survival', 'Mesenchymal Stem Cells', 'Nanofibers', 'Osteogenesis', 'Spectroscopy, Fourier Transform Infrared', 'Stem Cells', 'Tissue Engineering'] | 20,504,075 | [['D08.811.277.352.650.035'], ['A12.098', 'A16.378.149'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.152'], ['G04.346'], ['A11.329.830.500', 'A11.872.590.500'], ['J01.637.512.300'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['E05.196.712.726.676.700', 'E05.196.867.826.676.700... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A comparison of danazol and placebo in the treatment of adult idiopathic gynaecomastia: results of a prospective study in 55 patients. | In an attempt to define the efficacy of danazol in the treatment of idiopathic gynaecomastia, 55 patients were enrolled into a randomised double-blind comparison of danazol 200 mg twice daily for 3 months against placebo. The results of 52 patients were evaluated, three patients being excluded because of protocol viola... | ['Adolescent', 'Adult', 'Danazol', 'Double-Blind Method', 'Drug Administration Schedule', 'Gynecomastia', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Randomized Controlled Trials as Topic', 'Weight Gain'] | 2,221,763 | [['M01.060.057'], ['M01.060.116'], ['D04.210.500.745.432.235'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['C17.800.090.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effects of Vaseline gauze strip, Merocel, and Nasopore on the formation of synechiae and excessive granulation tissue in the middle meatus and the incidence of major postoperative bleeding after endoscopic sinus surgery. | BACKGROUND: Endoscopic sinus surgery (ESS) has become the widely accepted procedure for the treatment of medically refractory chronic rhinosinusitis and nasal polyps. Nasal packing is usually placed after ESS to prevent synechia formation and postoperative bleeding and to support wound healing. The aim of this study wa... | ['Adult', 'Aged', 'Bandages', 'Endoscopy', 'Epistaxis', 'Female', 'Formaldehyde', 'Granulation Tissue', 'Humans', 'Incidence', 'Logistic Models', 'Male', 'Middle Aged', 'Nasal Polyps', 'Paranasal Sinuses', 'Petrolatum', 'Polyvinyl Alcohol', 'Postoperative Complications', 'Retrospective Studies', 'Sinusitis'] | 21,292,198 | [['M01.060.116'], ['M01.060.116.100'], ['E07.101'], ['E01.370.388.250', 'E04.502.250'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.040'], ['D02.047.407'], ['A10.165.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Redistribution of SERCA calcium pump conformers during intracellular calcium signaling. | The conformational changes of a calcium transport ATPase were investigated with molecular dynamics (MD) simulations as well as fluorescence resonance energy transfer (FRET) measurements to determine the significance of a discrete structural element for regulation of the conformational dynamics of the transport cycle. P... | ['Calcium', 'Calcium Signaling', 'Crystallography, X-Ray', 'Endoplasmic Reticulum', 'Humans', 'Models, Molecular', 'Molecular Dynamics Simulation', 'Protein Binding', 'Protein Conformation', 'RNA, Small Interfering', 'Sarcoplasmic Reticulum Calcium-Transporting ATPases'] | 29,764,938 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['E05.196.309.742.225'], ['A11.284.430.214.190.875.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G02.111.679', 'G... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Therapeutic arterial embolization in trauma. | Use of therapeutic arterial embolization (TAE) in the traumatized patient can achieve rapid control of hemorrhage and obviate the need for immediate surgery on poor-risk patients or in high-risk areas of the body. The techniques of embolization, its risks, and complications are discussed in light of the authors' experi... | ['Adolescent', 'Adult', 'Aged', 'Angiography', 'Arteries', 'Embolization, Therapeutic', 'Female', 'Femoral Artery', 'Hemorrhage', 'Humans', 'Iliac Artery', 'Male', 'Middle Aged', 'Risk', 'Subclavian Artery', 'Thoracic Arteries', 'Vertebral Artery', 'Wounds and Injuries'] | 513,174 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early rehabilitation of higher cortical brain functioning in neurosurgery, humanizing the restoration of human skills after acute brain lesions. | OBJECTIVE: Increasingly more patients after brain damage survive, however, suffering from severe impairments of higher cerebral functioning.METHODS: Patients after acute brain damage, mainly secondary to TBI, are referred for early neurosurgical rehabilitation. Our concept follows the German Guidelines. It is based on ... | ['Cerebral Cortex', 'Humans', 'Neurosurgical Procedures', 'Occupational Therapy', 'Physical Therapy Modalities', 'Postoperative Complications', 'Psychotherapy', 'Speech', 'Taste'] | 17,370,755 | [['A08.186.211.200.885.287.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.525'], ['E02.760.169.063.500.489', 'E02.831.489', 'H02.010.500'], ['E02.779', 'E02.831.535'], ['C23.550.767'], ['F04.754'], ['F01.145.209.908.677', 'G11.561.812', 'L01.559.423.676'], ['F02.830.816.724', 'G11.561.790.724']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Medical and socio-professional impact of insomnia. | STUDY OBJECTIVES: Insomnia, a highly prevalent disorder with direct and indirect economic and professional consequences, affects daytime functioning, behavior, and quality of life. Several studies have shown that insomnia affects the workforce and is associated with an increased risk of accidents. Insomnia may also pla... | ['Accidents, Occupational', 'Family', 'Female', 'France', 'Health Care Costs', 'Health Status', 'Hospitalization', 'Humans', 'Male', 'Office Visits', 'Prevalence', 'Quality of Life', 'Sleep Initiation and Maintenance Disorders', 'Surveys and Questionnaires', 'Workplace'] | 12,224,841 | [['N06.850.135.240'], ['F01.829.263', 'I01.880.853.150'], ['Z01.542.286'], ['N03.219.151.400', 'N05.300.375'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.758.635'], ['E05.318.308.985.525.750', 'N01.224.935.597.750... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Humanities [K]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
From patenting genes to proteins: the search for utility via function. | The debate regarding the patenting of genes has extended into the post-genome era. With only approximately 35000 genes deduced from the draft sequence of the human genome, there are fears that a few companies have already gained monopoly on the potential benefits from this knowledge. Nevertheless, it is accepted that p... | ['DNA', 'Entrepreneurship', 'Europe', 'Government Agencies', 'Guidelines as Topic', 'Humans', 'Ownership', 'Patents as Topic', 'Proteins', 'Public Policy', 'Socioeconomic Factors', 'United States'] | 11,943,374 | [['D13.444.308'], ['J01.219.375', 'N04.452.610.250'], ['Z01.542'], ['I01.409.418', 'N03.540.400'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583.594', 'N04.452.633'], ['I01.880.604.583.458.650', 'N03.706.535.518.650'], ['D12.776'], ['I01.655.500.608', 'I01.880.60... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
An implicit measure of olfactory performance for non-human primates reveals aversive and pleasant odor conditioning. | We have little understanding of how odorants are processed in neural networks of the primate brain. Because chemo-stimuli are harder to control than physical stimuli (e.g. vision, audition), such research was limited by the temporal resolution, accuracy, and reliability of olfactometers (odor producing machines). Recen... | ['Animals', 'Association Learning', 'Behavior, Animal', 'Conditioning, Classical', 'Electrophysiology', 'Emotions', 'Humans', 'Macaca fascicularis', 'Male', 'Odorants', 'Respiratory Mechanics', 'Smell'] | 20,688,103 | [['B01.050'], ['F02.463.425.069.296'], ['F01.145.113'], ['F02.463.425.179.308'], ['H01.158.344.528', 'H01.158.782.236'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['G16.500.275.640', 'N06.230.480'], ['G09.772.705.700'], ['F02.830.816.643', 'G1... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
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