Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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A validation study of the Whitely Index, the Illness Attitude Scales, and the Somatosensory Amplification Scale in general medical and general practice patients. | The aim of this study was to assess the reliability and validity of the Whitely Index (WI), the Illness Attitude Scales (IAS), and the Somatosensory Amplification Scale (SAS). The study population consisted of 130 general medical outpatients, 113 general practice patients, and 204 subjects from the general population. ... | ['Adult', 'Attitude to Health', 'Family Practice', 'Female', 'Health Services', 'Humans', 'Hypochondriasis', 'Male', 'Middle Aged', 'Prospective Studies'] | 8,730,649 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['H02.403.340.500'], ['N02.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.875.450'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
[Dental implants in tooth grinders]. | Bruxism (tooth grinding and clenching) is generally considered a contraindication for dental implants, although the evidence is usually based on clinical experience only. So far, studies to the possible cause-and-effect relationship between bruxism and implant failure do not yield consistent and specific outcomes. This... | ['Bite Force', 'Bruxism', 'Dental Implants', 'Dental Prosthesis Design', 'Dental Prosthesis, Implant-Supported', 'Dental Restoration Failure', 'Dental Stress Analysis', 'Humans', 'Occlusal Splints'] | 15,058,243 | [['E06.276.125'], ['C07.793.099', 'F01.145.466.132', 'F01.470.315.500'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['E06.780.346.625', 'E06.912.145'], ['E06.780.346.706', 'E07.695.190.185'], ['E06.323.400', 'E06.780.346.725'], ['E06.308'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aâ- induced Alzheimer disease. | Mesenchymal stem cell (MSC) transplantation therapy has been proposed as a promising approach for the treatment of neurodegenerative disease. Chemical and pharmacological preconditioning before transplantation could optimize the therapeutic properties of transplanted MSCs. In this study, we hypothesized that preconditi... | ['Alzheimer Disease', 'Amino Acids, Dicarboxylic', 'Amyloid beta-Peptides', 'Animals', 'Cell Survival', 'Disease Models, Animal', 'Mesenchymal Stem Cell Transplantation', 'Mesenchymal Stem Cells'] | 30,500,334 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.125.119'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['G04.346'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.095.147.500.500.625', 'E04.936.225.687.625'], ['A11.329.830.500', 'A11.872.590.500']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of miR-96 and miR-133a Expression in Gastrointestinal Neuroendocrine Neoplasms. | Grading of gastrointestinal neuroendocrine neoplasms (GI-NENs) relies mainly on mitotic activity and Ki-67 proliferation index. It is often difficult to predict metastatic potential of these neoplasms. Recent studies have shown that GI-NENs express a wide spectrum of microRNAs. We examined two microRNAs (miR-96 and miR... | ['Biomarkers, Tumor', 'Female', 'Gastrointestinal Neoplasms', 'Humans', 'Male', 'MicroRNAs', 'Neoplasm Grading', 'Neuroendocrine Tumors'] | 29,032,398 | [['D23.101.140'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E01.789.612'], ['C04.557.465.625.650', 'C04.557.580.625.650']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Denaturing interaction between sickle hemoglobin and phosphatidylserine liposomes. | It is hypothesized that abnormal interaction between sickle hemoglobin (HbS) and erythrocyte membrane lipid might promote deposition of denatured hemoglobin (hemichrome) on the membrane. We compared the interaction of HbS and normal HbA with large unilamellar phosphatidylserine (PS) liposomes under low salt/pH conditio... | ['Heme', 'Hemoglobin, Sickle', 'Humans', 'Iron', 'Lipid Peroxidation', 'Liposomes', 'Oxidation-Reduction', 'Oxyhemoglobins', 'Phosphatidylcholines', 'Protein Denaturation'] | 8,274,739 | [['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['D12.776.124.400.463.588', 'D12.776.422.316.762.426.588'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['G02.111.515', 'G03.295.531.587'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cyclic regulation of apoptotic gene expression in the mouse oviduct. | The oviduct is a dynamic structure whose function relies upon cyclic changes in the morphology of both ciliated and secretory luminal epithelial cells. Unfortunately, infection of these epithelial cells by sexually transmitted pathogens can lead to pelvic inflammatory disease, ectopic pregnancies and infertility. The d... | ['Analysis of Variance', 'Animals', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Blotting, Western', 'Caspases', 'Epithelial Cells', 'Estrus', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Mice', 'Oviducts', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Time Factors'] | 21,635,812 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Positive results bias in pediatric ophthalmology scientific publications. | Previous studies in several fields of medicine, including general ophthalmology, have revealed a positive results bias, demonstrating an association between the results of a trial and the impact factor (IF) of the journal in which it was published. We hypothesized that randomized clinical studies in pediatric ophthalmo... | ['Humans', 'Journal Impact Factor', 'Ophthalmology', 'Pediatrics', 'Periodicals as Topic', 'Publication Bias', 'Randomized Controlled Trials as Topic'] | 30,077,820 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.178.682.099.325.500', 'L01.453.183.291.500'], ['H02.403.810.468'], ['H02.403.670'], ['L01.178.682.829.678'], ['L01.737.813'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500']] | ['Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
The Chitinase A from the baculovirus AcMNPV enhances resistance to both fungi and herbivorous pests in tobacco. | Biotechnology has allowed the development of novel strategies to obtain plants that are more resistant to pests, fungal pathogens and other agents of biotic stress. The obvious advantages of having genotypes with multiple beneficial traits have recently fostered the development of gene pyramiding strategies, but less a... | ['Amino Acid Sequence', 'Animals', 'Aphids', 'Baculoviridae', 'Base Sequence', 'Chitinases', 'Fungi', 'Gene Expression Regulation, Enzymologic', 'Host-Pathogen Interactions', 'Larva', 'Lepidoptera', 'Molecular Sequence Data', 'Nucleopolyhedroviruses', 'Pest Control, Biological', 'Plants, Genetically Modified', 'Recombi... | 17,851,776 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.500.131.617.412.165'], ['B04.280.065', 'B04.525.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.450.207'], ['B01.300'], ['G05.308.320'], ['G06.462', 'G16.527.200'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Pathophysiology and treatment of corneal hydrops. | The new application of thermokeratoplasty as a treatment of both acute and chronic hydrops is presented as a possible alternative to present treatment regimens. The histopathology of keratoconus and hydrops is reviewed relating to thermokeratoplasty effect. Clinical success was achieved in the elimination of pain from ... | ['Corneal Diseases', 'Edema', 'Hot Temperature', 'Humans', 'Keratoconus'] | 1,004,808 | [['C11.204'], ['C23.888.277'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.627']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chromosome aberration frequencies produced by a 70-MeV proton beam. | The effectiveness of a 70-MeV proton beam in the induction of chromosome aberrations was studied. We employed peripheral lymphocytes and analyzed the frequencies of dicentrics and rings after irradiation at doses ranging from 0.1 to 8.0 Gy at various depths within a Lucite phantom. The frequency of chromosome aberratio... | ['Adult', 'Chromosome Aberrations', 'Dose-Response Relationship, Radiation', 'Humans', 'Lymphocytes', 'Particle Accelerators', 'Protons', 'Relative Biological Effectiveness'] | 2,167,496 | [['M01.060.116'], ['C23.550.210', 'G05.365.590.175'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['E07.710.680'], ['D01.248.497.300.459... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Levels and sub-cellular distribution of physiologically important metal ions in neuronal cells cultured from chick embryo cerebral cortex. | Mg2+, Ca2+, Mn2+, Zn2+, and Cu content of neurons from chick embryo cortex cultivated in chemically defined serum free growth medium was determined by energy dispersive X-ray fluorescence and atomic absorption spectroscopy. The intracellular volume of cultured neurons was determined to be 2.73 microliters/mg. Intracell... | ['Animals', 'Cations, Divalent', 'Cells, Cultured', 'Cerebral Cortex', 'Chick Embryo', 'Metals', 'Neurons'] | 3,237,309 | [['B01.050'], ['D01.248.497.300.333'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['A13.350.150', 'A16.331.200'], ['D01.552'], ['A08.675', 'A11.671']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemia. | Our objective was to explore associations of circulating factors implicated in insulin-like growth factor- 1 receptor (IGF-1R) signaling with clinical outcomes of patients with acute myeloid leukemia (AML). Pretreatment blood samples from patients with non-M3 AML (n = 30) were collected prospectively and levels of IGF ... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Biomarkers', 'Female', 'Humans', 'Insulin-Like Growth Factor Binding Proteins', 'Insulin-Like Growth Factor I', 'Kaplan-Meier Estimate', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Prognosis', 'Treatment Outcome'] | 25,735,964 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.420'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues. | Effects of iron deficiency on the distribution of iron and glutamate decarboxylase (GAD), gamma-aminobutyric acid transaminase (GABA-T) activities and GABA concentrations in different brain regions in young rats were investigated. Iron deficiency was induced by feeding an iron-depleted diet (0.32mg/100g) in weanling ra... | ['4-Aminobutyrate Transaminase', 'Anemia, Iron-Deficiency', 'Animals', 'Brain', 'Glutamate Decarboxylase', 'Glutamic Acid', 'Glutamine', 'Hematologic Tests', 'Iron', 'Male', 'Rats', 'Rats, Wistar', 'Trace Elements', 'gamma-Aminobutyric Acid'] | 9,719,948 | [['D08.811.913.477.700.200'], ['C15.378.071.196.300', 'C18.452.565.100'], ['B01.050'], ['A08.186.211'], ['D08.811.520.224.125.250'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['E01.370.225.625', 'E05.200.625'], ['D01.268.556.412', 'D01.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Limb and gender differences in the development of coordination in early infancy. | Young infants produce a variety of spontaneous arm and leg movements in the first few months of life. Coordination of leg joints has been extensively investigated, whereas arm joint coordination has mainly been investigated in the sitting position in the context of early reaching and grasping. The current study investi... | ['Age Factors', 'Child Development', 'Female', 'Functional Laterality', 'Humans', 'Infant', 'Male', 'Motor Activity', 'Psychomotor Performance', 'Reference Values', 'Sex Factors'] | 12,620,715 | [['N05.715.350.075', 'N06.850.490.250'], ['F01.525.200', 'G07.345.374.750'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F01.145.632', 'G11.427.410.698'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['E05.978.810'], ['N05.715.350.675', 'N06.850.490.875']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines: investigator-blinded, randomized clinical trial. | BACKGROUND: Post-inflammatory hyperpigmentation is a frequent concern when treating solar lentigines.OBJECTIVES: To assess the safety and efficacy of a triple combination cream with fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05% as adjuvant to cryotherapy in the treatment of solar lentigines in hands... | ['Anti-Inflammatory Agents', 'Antineoplastic Agents', 'Antioxidants', 'Chemotherapy, Adjuvant', 'Cryotherapy', 'Drug Combinations', 'Erythema', 'Female', 'Fluocinolone Acetonide', 'Hand Dermatoses', 'Humans', 'Hydroquinones', 'Lentigo', 'Male', 'Melanins', 'Middle Aged', 'Prospective Studies', 'Single-Blind Method', 'S... | 24,684,165 | [['D27.505.954.158'], ['D27.505.954.248'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E02.186.170', 'E02.319.170'], ['E02.258'], ['D26.310'], ['C17.800.229', 'C23.888.885.328'], ['D04.210.500.745.432.370', 'D04.210.500.908.394'], ['C17.800.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Case management]. | The present paper discusses the theoretical background and present the practical use of the case management model of psychiatric care. Case management is a model of psychiatric care, in which the therapeutic effort is not restricted to biological and psychological functioning of the patient, but is also directed at rei... | ['Case Management', 'Community Mental Health Services', 'Humans', 'Poland', 'Schizophrenia'] | 9,739,184 | [['N04.590.233.624.250'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.248.679'], ['F03.700.750']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Endoscope-assisted excision of a juxtafacet cyst in an adolescent athlete: a case report. | BACKGROUND: Juxtafacet cysts (JFCs) are a cause of back and radicular pain that can be treated conservatively and operatively. Such strategies include lumbosacral brace, epidural injection, open surgery, and minimally invasive surgery; although surgical treatment is usually reserved for unsuccessful conservative treatm... | ['Adolescent', 'Basketball', 'Cystectomy', 'Cysts', 'Endoscopy', 'Humans', 'Low Back Pain', 'Magnetic Resonance Imaging', 'Male', 'Minimally Invasive Surgical Procedures', 'Pain', 'Recovery of Function', 'Treatment Outcome', 'Zygapophyseal Joint'] | 23,076,813 | [['M01.060.057'], ['I03.450.642.845.117'], ['E04.950.774.150'], ['C04.182', 'C23.300.306'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['E01.370.350.825.500'], ['E04.502'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['G16.757'], ['E0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer. | Interference with polyamine transport and biosynthesis has emerged as an important anticancer strategy involving polyamine analogues and specific inhibitors of key biosynthetic enzymes. Because the prostate gland has a high polyamine content, by using the polyamine transporter for selective uptake into cancer cells, al... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Aziridines', 'Humans', 'Male', 'Mice', 'Mice, SCID', 'Prostatic Neoplasms', 'Radiation-Sensitizing Agents', 'Spermine', 'Tumor Cells, Cultured'] | 9,809,992 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['D03.383.097.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.780'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D27.505.954.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Glasgow Prognostic Score is a good predictor of treatment outcome in patients with unresectable pancreatic cancer. | BACKGROUND: We analyzed the outcome of patients with advanced unresectable pancreatic cancer treated in our department from 2001 to 2008.METHODS: Of the 83 patients included in this study, 50 patients received single-agent treatment with gemcitabine (GEM), 9 patients GEM combined with radiotherapy (GEM+R) and 24 patien... | ['Adult', 'Aged', 'Antimetabolites, Antineoplastic', 'Combined Modality Therapy', 'Deoxycytidine', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pancreatic Neoplasms', 'Prognosis', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome', 'Young Adult'] | 21,099,223 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['E02.186'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
OntoTrader: an ontological Web trading agent approach for environmental information retrieval. | Modern Web-based Information Systems (WIS) are becoming increasingly necessary to provide support for users who are in different places with different types of information, by facilitating their access to the information, decision making, workgroups, and so forth. Design of these systems requires the use of standardize... | ['Data Mining', 'Environment', 'Geographic Information Systems', 'Internet', 'Natural Language Processing', 'Social Media', 'Software', 'Vocabulary, Controlled'] | 24,977,211 | [['L01.313.500.750.280.199', 'L01.470.625'], ['G16.500.275', 'N06.230'], ['L01.313.500.750.300.314', 'L01.470.750.750.462'], ['L01.224.230.110.500'], ['L01.224.050.375.580'], ['L01.178.751', 'L01.224.230.110.500.750'], ['L01.224.900'], ['L01.453.245.945']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
CtrA response regulator binding to the Caulobacter chromosome replication origin is required during nutrient and antibiotic stress as well as during cell cycle progression. | The Caulobacter crescentus chromosome replication origin (Cori) has five binding sites for CtrA, an OmpR/PhoB family 'response regulator'. CtrA is degraded in replicating 'stalked' cells but is abundant in the non-replicating 'swarmer' cells, where it was proposed to repress replication by binding to Cori. We systemati... | ['Anti-Bacterial Agents', 'Bacterial Proteins', 'Binding Sites', 'Caulobacter crescentus', 'Cell Cycle', 'Chromosomes, Bacterial', 'DNA Replication', 'DNA, Bacterial', 'DNA-Binding Proteins', 'Gene Expression Regulation, Bacterial', 'Mutagenesis, Site-Directed', 'Mutation', 'Plasmids', 'Replication Origin', 'Stress, Ph... | 19,220,749 | [['D27.505.954.122.085'], ['D12.776.097'], ['G02.111.570.120'], ['B03.440.400.280.280', 'B03.440.400.425.288.100.100', 'B03.660.050.090.100.100'], ['G04.144'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['G02.111.225', 'G05.226'], ['D13.444.308.212'], ['D12.776.260'], ['G05.308.300'], ['E05.393.420.601.575'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DeepHINT: understanding HIV-1 integration via deep learning with attention. | MOTIVATION: Human immunodeficiency virus type 1 (HIV-1) genome integration is closely related to clinical latency and viral rebound. In addition to human DNA sequences that directly interact with the integration machinery, the selection of HIV integration sites has also been shown to depend on the heterogeneous genomic... | ['Attention', 'Deep Learning', 'Genomics', 'HIV-1', 'Humans', 'Software', 'Virus Internalization'] | 30,295,703 | [['F02.830.104.214'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.900'], ['G06.920.881']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Bayesian models for semicontinuous outcomes in rolling admission therapy groups. | Alcohol and other drug abuse are frequently treated in a group therapy setting. If participants are allowed to enroll in therapy on a rolling basis, irregular patterns of participant overlap can induce complex correlations of participant outcomes. Previous work has accounted for common session attendance by modeling ra... | ['Adult', 'Alcohol-Related Disorders', 'Bayes Theorem', 'Depression', 'Humans', 'Models, Statistical', 'Outcome Assessment, Health Care', 'Psychotherapy, Group'] | 29,265,849 | [['M01.060.116'], ['C25.775.100', 'F03.900.100'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['H01.770.644.145.431', 'N04.761.559.59... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection. | UNLABELLED: Infection with hepatitis B virus (HBV) is the most common cause of liver disease worldwide. However, because the current interferon (IFN)-based treatments have toxic side effects and marginal efficacy, improved antivirals are essential. Here we report that unmethylated cytosine-phosphate-guanosine oligodeox... | ['Animals', 'Cells, Cultured', 'Cytosine', 'Dendritic Cells', 'Disease Models, Animal', 'Guanosine', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Humans', 'Immunity, Innate', 'Immunotherapy', 'In Vitro Techniques', 'Interferon-alpha', 'Lymphocytes', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C... | 23,907,803 | [['B01.050'], ['A11.251'], ['D03.383.742.698.421'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.453'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437']... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
HELLP syndrome: an atypical presentation. | HELLP syndrome without proteinuria or hypertension is rare. We present the case of a 33-year-old primigravid who initially was diagnosed with pulmonary embolism. The patient was readmitted with a diagnosis of subcapsular hematoma and eventually diagnosed with HELLP syndrome with a sequela of hepatic rupture. | ['Adult', 'Female', 'HELLP Syndrome', 'Hematoma', 'Humans', 'Infant, Newborn', 'Liver Diseases', 'Male', 'Pregnancy', 'Pregnancy Outcome', 'Pulmonary Embolism', 'Rupture, Spontaneous', 'Ultrasonography, Prenatal'] | 18,342,825 | [['M01.060.116'], ['C13.703.395.186'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C06.552'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['C08.381.746', 'C14.907.355.350.700'], ['C23.300.909'], ['E01.370.350.850.865', 'E01.370.378.630.865']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The passage of Florida's Statute on Assisted Reproductive Technology. | Until 1993, there were no statutes in the United States covering gestational surrogacy contracts, disposition of stored embryos and gametes, parentage of children born from donated gametes and embryos, and the inheritance rights of cryopreserved embryos of deceased donors. In March 1993, the Florida Assisted Reproducti... | ['Female', 'Florida', 'Humans', 'Pregnancy', 'Reproductive Techniques', 'Surrogate Mothers'] | 7,936,533 | [['Z01.107.567.875.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E02.875', 'E05.820'], ['F01.829.263.500.320.892', 'I01.880.853.150.500.340.892', 'M01.620.892']] | ['Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Looking for suitable biomarkers in benthic macroinvertebrates inhabiting coastal areas with low metal contamination: comparison between the bivalve Cerastoderma edule and the Polychaete Diopatra neapolitana. | Metals accumulated in marine sediments are often a threat to benthic communities. With the recognized importance and wide use of stress biochemical responses as indicators of metal contamination it becomes essential to compare these markers between different species and verify their ubiquity and accuracy. Using wild Di... | ['Animals', 'Biomarkers', 'Cardiidae', 'Catalase', 'Environmental Monitoring', 'Geologic Sediments', 'Glutathione Transferase', 'Lipid Peroxidation', 'Metallothionein', 'Metals', 'Oxidative Stress', 'Polychaeta', 'Superoxide Dismutase', 'Water Pollutants, Chemical'] | 21,890,202 | [['B01.050'], ['D23.101'], ['B01.050.500.644.080.150'], ['D08.811.682.732.332'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.330', 'G16.500.320'], ['D08.811.913.225.500'], ['G02.111.515', 'G03.295.531.587'], ['D12.776.556.670'], ['D01.552'], ['G03.673', 'G07.775.750'], ['B01.050.500.091.700'], ['D08.811.682.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Red-shifted voltage-sensitive fluorescent proteins. | Electrical signals generated by nerve cells provide the basis of brain function. Whereas single or small numbers of cells are easily accessible using microelectrode recording techniques, less invasive optogenetic methods with spectral properties optimized for in vivo imaging are required for elucidating the operation m... | ['Animals', 'Cell Line, Tumor', 'Electrophysiological Phenomena', 'Kinetics', 'Luminescent Proteins', 'Microelectrodes', 'Neurons', 'Phosphoric Monoester Hydrolases', 'Rats', 'Recombinant Fusion Proteins'] | 20,064,437 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G07.265'], ['G01.374.661', 'G02.111.490'], ['D12.776.532'], ['E07.305.250.500'], ['A08.675', 'A11.671'], ['D08.811.277.352.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.828.300']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Capital juror questionnaires in death-penalty cases: A study of attitudes, denials, and deceptions. | The Sixth Amendment right to an "impartial jury" should guarantee fundamental fairness that in capital cases may literally be a matter of life and death. For ecological validity, the current study focuses on capital jury questionnaires (CJQs) employed in actual death-penalty cases. Study I examined 248 undergraduates a... | ['Adolescent', 'Adult', 'Capital Punishment', 'Criminal Law', 'Deception', 'Decision Making', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Research Design', 'Surveys and Questionnaires', 'Young Adult'] | 32,092,189 | [['M01.060.057'], ['M01.060.116'], ['I01.880.604.160'], ['I01.198.290', 'I01.880.604.583.100'], ['F01.145.813.157'], ['F02.463.785.373'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.581.500', 'H01.770.644.728'], ['E05.318.308.980', 'N05.715.360.300... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Changes in dicot-weeds species composition in spring barley in Latvia during the past 20 years. | Dicot weed populations were assessed in spring barley trials carried out in four three-years periods at 5-year intervals: 1990-1992, 1995-1997; 2001-2003 and 2006-2008. The overall aim of this research was to evaluate the changes in dicot-weed infestations in spring barley in fields of one region (Riga) of Latvia in so... | ['Herbicides', 'Hordeum', 'Introduced Species', 'Latvia', 'Plant Weeds', 'Species Specificity', 'Temperature', 'Time Factors', 'Weather'] | 23,878,992 | [['D27.720.031.700.366', 'D27.888.723.366'], ['B01.650.940.800.575.912.250.822.481'], ['B01.050.050.580', 'G16.500.275.157.049.400', 'N06.230.124.049.400'], ['Z01.542.248.136.560'], ['B01.650.449'], ['G16.824'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.71... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Pre-adsorbed type-I collagen structure-dependent changes in osteoblastic phenotype. | Type-I collagen is the most abundant extracellular matrix in bones and modulates various functions of osteoblasts. We prepared two different structures of type-I collagen on tissue culture grade polystylene (TCPS) surfaces, one is feltwork structure of filamentous molecules from acid solutions (ACs) and the other is ne... | ['Animals', 'Calcification, Physiologic', 'Cell Adhesion', 'Cell Line', 'Cell Proliferation', 'Collagen Type I', 'Gene Expression', 'Mice', 'Osteoblasts', 'Phenotype'] | 16,647,688 | [['B01.050'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['G04.022'], ['A11.251.210'], ['G04.161.750', 'G07.345.249.410.750'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['G05.297'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.329.629'], ['G05.695']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. | This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen ... | ['1,2-Dimethylhydrazine', 'Aberrant Crypt Foci', 'Animals', 'Biomarkers', 'Carcinogenesis', 'Carcinogens', 'Cell Proliferation', 'Colorectal Neoplasms', 'Cyclooxygenase 2', 'Dietary Supplements', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Gene Expression Regulation, Neoplastic', 'Glutathione', 'Homo... | 25,123,248 | [['D02.442.600.400.200'], ['C04.834.020'], ['B01.050'], ['D23.101'], ['C04.697.098', 'C23.550.727.098'], ['D27.888.569.100'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D08.811.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Metal-assisted polyatomic SIMS and laser desorption/ionization for enhanced small molecule imaging of bacterial biofilms. | Mass spectrometry imaging (MSI) has become an important analytical tool for many sectors of science and medicine. As the application of MSI expands into new areas of inquiry, existing methodologies must be adapted and improved to meet emerging challenges. Particularly salient is the need for small molecule imaging meth... | ['Biofilms', 'Metals', 'Optical Imaging', 'Pseudomonas aeruginosa', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Spectrometry, Mass, Secondary Ion'] | 26,945,568 | [['A20.593', 'G06.120'], ['D01.552'], ['E01.370.350.589', 'E05.642'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['E05.196.566.755'], ['E05.196.566.760']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Allograft mass as a possible contributing factor to the skin transplant outcome. | BACKGROUND: A composite tissue consists of tissues derived from ectoderm and mesoderm typically containing skin, fat, muscle, nerves, lymph nodes, bone, bone marrow or any combination of these. Solid organ transplants possessing larger allograft mass were reported to survive better. As for the vascularized composite ti... | ['Animals', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Flow Cytometry', 'Forelimb', 'Graft Survival', 'Hindlimb', 'Histocompatibility Testing', 'Male', 'Rats', 'Rats, Inbred BN', 'Rats, Inbred Lew', 'Skin', 'Skin Transplantation', 'Surgical Flaps', 'Transplantation Chimera', 'Transplantation, Homologo... | 20,478,759 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342',... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Curtailed binomial sampling procedures for clinical trials with paired data. | The use of curtailed sampling procedures in designing clinical trials with a dichotomous response and paired data is reviewed. Tables of expected sample size savings and a simple to evaluate asymptotic formula for the expected sample size savings are presented where the sample size savings is calculated relative to the... | ['Clinical Trials as Topic', 'Humans', 'Mathematics', 'Research Design', 'Sampling Studies', 'Statistics as Topic'] | 3,987,301 | [['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['E05.581.500', 'H01.770.644.728'], ['E05.318.372.875', 'N05.715.360.330.875', 'N06.850.520.450.875'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2á) pathway protect ovarian cancer cells from metformin-induced apoptosis. | Metformin, an oral biguanide for the treatment of type II diabetes, has been shown to have anticancer effects in ovarian cancer. Energy starvation induced by metformin causes endoplasmic reticulum stress-mediated unfolded protein response (UPR) and autophagy. UPR and autophagy act as a survival or death mechanism in ce... | ['Antineoplastic Agents', 'Apoptosis', 'Autophagy', 'Cell Line, Tumor', 'Cells, Cultured', 'Eukaryotic Initiation Factor-2', 'Female', 'Humans', 'Hypoglycemic Agents', 'Metformin', 'Ovarian Neoplasms', 'Ovary', 'Signal Transduction', 'eIF-2 Kinase'] | 25,663,310 | [['D27.505.954.248'], ['G04.146.954.035'], ['G04.011'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['D12.776.835.725.868.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['D02.078.370.141.450'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification and characterization of a heat- and acid-stable progestin binding protein of rat lung. | We report on the purification and characterization of a heat- and acid-stable progestin binding protein of rat lung cytosol, the binding behaviour and capacity of which have already been described by us. Using heat treatment, fractionated acetone precipitation, DEAE, HAP and Sephadex G-100 chromatography, the protein w... | ['Animals', 'Chemical Precipitation', 'Chromatography, Ion Exchange', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'Kinetics', 'Lung', 'Mice', 'Molecular Weight', 'Progesterone-Binding Globulin', 'Receptors, Progesterone', 'Species Specificity', 'Ultracentrifugation'] | 2,755,124 | [['B01.050'], ['E05.196.150', 'G02.159'], ['E05.196.181.400.383'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.196.401.402', 'E05.301.300.319'], ['G01.374.661', 'G02.111.490'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.494'], ['D12.776.124.790.106.740', 'D12.776.37... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs). | Tenofovir, a well-known and highly prescribed anti-HIV-1 drug for the treatment of HIV/AIDS infections, has recently also shown its effectiveness as a potential microbicide drug in the prevention of HIV transmission. Here, we evaluated the combination of tenofovir with various members of the class of carbohydrate-bindi... | ['Adenine', 'Anti-HIV Agents', 'Cell Line', 'Drug Synergism', 'HIV Envelope Protein gp120', 'HIV Infections', 'HIV-1', 'Humans', 'Organophosphonates', 'Tenofovir'] | 21,501,631 | [['D03.633.100.759.138'], ['D27.505.954.122.388.077.088'], ['A11.251.210'], ['G07.690.773.968.477'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phase separations in liquid crystal-colloid mixtures. | We present a mean-field theory to describe phase separations in mixtures of a nematic liquid crystal and a colloidal particle. The theory takes into account an orientational ordering of liquid crystals and a crystalline ordering of colloidal particles. We calculate phase diagrams on the temperature-concentration plane,... | ['Algorithms', 'Colloids', 'Crystallization', 'Liquid Crystals', 'Nanostructures', 'Phase Transition', 'Surface Properties', 'Temperature'] | 18,248,000 | [['G17.035', 'L01.224.050'], ['D20.280', 'D26.255.165'], ['E05.196.300', 'G02.171'], ['J01.637.506'], ['J01.637.512'], ['G01.645', 'G02.734'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse. | This study describes cytoarchitectonic criteria to define the prefrontal cortical areas in the mouse brain (C57BL/6 strain). Currently, well-illustrated mouse brain stereotaxic atlases are available, which, however, do not provide a description of the distinctive cytoarchitectonic characteristics of individual prefront... | ['Acetylcholinesterase', 'Animals', 'Brain Mapping', 'Calbindins', 'Dopamine', 'Histocytochemistry', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Myelin Sheath', 'Neural Pathways', 'Neurofilament Proteins', 'Parvalbumins', 'Prefrontal Cortex', 'S100 Calcium Binding Protein G'] | 20,221,886 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D12.776.157.125.090'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment response evaluation using the mean apparent diffusion coefficient in cervical cancer patients treated with definitive chemoradiotherapy. | PURPOSE: To investigate the pre- and posttreatment mean apparent diffusion coefficient (ADCmean ) of cervical cancer tumors treated with definitive chemoradiotherapy (CRT) and evaluate their correlation with recurrence and survival rates.MATERIALS AND METHODS: Forty-four patients with cervical squamous cell carcinoma w... | ['Adult', 'Aged', 'Aged, 80 and over', 'Algorithms', 'Chemoradiotherapy', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Middle Aged', 'Prevalence', 'Prognosis', 'Reproducibility of Results', 'Retrospective Studies', 'Risk Assessment', 'Sensi... | 26,919,800 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['E01.370.350.825.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Circulating and tumor-infiltrating gamma delta T Cells in patients with B-cell lymphomas. | In order to analyze the involvement of gamma delta T cells in the immune surveillance against B cell lymphomas (BCL), we investigated the proportion of circulating gamma delta T cells in 52 BCL patients using two-color flow cytometry, together with tumor-infiltrating gamma delta T cells in 22 of those patients. We foun... | ['Adult', 'Age Factors', 'Aged', 'Blood Circulation', 'Flow Cytometry', 'Humans', 'Immune System', 'Lymph Nodes', 'Lymphocytes, Tumor-Infiltrating', 'Lymphoma, B-Cell', 'Matched-Pair Analysis', 'Middle Aged', 'Prognosis', 'Pseudolymphoma', 'Receptors, Antigen, T-Cell, gamma-delta', 'T-Lymphocytes'] | 11,342,312 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['G09.330.100'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A1... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chemical speciation and bioaccessibility of lead in surface soil and house dust, Lavrion urban area, Attiki, Hellas. | In the Lavrion urban area study, Hellas, a five-step sequential extraction method was applied on samples of 'soil' (n = 224), affected by long-term mining and metallurgical activities, and house dust (n = 127), for the purpose of studying the potential bioaccessibility of lead and other metals to humans. In this paper,... | ['Carbonates', 'Child', 'Dust', 'Environmental Monitoring', 'Environmental Pollutants', 'Greece', 'Humans', 'Hydrogen-Ion Concentration', 'Lead', 'Metallurgy', 'Mining', 'Risk Assessment', 'Soil'] | 20,524,052 | [['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['M01.060.406'], ['D20.633.222'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['Z01.542.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D01.268.556.435', 'D01.552.544.435'], ['J01.576.655.875.400'], ['J01.576.655.875.500... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Tissue specific toxicities of the anticancer drug 6-thioguanine is dependent on the Hprt status in transgenic mice. | 6-Thioguanine (6TG) a cytostatic antimetabolite is currently used to treat patients with cancer, in particular leukemias. However, one drawback of such use is the development of 6TG resistance. Hypoxanthine-guanine phosphoribosyl transferase (Hprt) plays a crucial role in the bioactivation of 6TG. Loss of Hprt has been... | ['Adenine', 'Adenine Phosphoribosyltransferase', 'Animals', 'Antineoplastic Agents', 'Enzyme Inhibitors', 'Female', 'Hypoxanthine Phosphoribosyltransferase', 'Mice', 'Mice, Transgenic', 'Organ Specificity', 'Thioguanine'] | 9,262,380 | [['D03.633.100.759.138'], ['D08.811.913.400.725.100'], ['B01.050'], ['D27.505.954.248'], ['D27.505.519.389'], ['D08.811.913.400.725.450'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['G07.650'], ['D03.633.100.759.854']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Leukotriene B4 generation by human monocytes and neutrophils stimulated by uropathogenic strains of Escherichia coli. | The generation of the 5-lipoxygenase product, leukotriene B4 (LTB4) by human mononuclear phagocytes (monocytes) following incubation with 25 different uropathogenic strains of Escherichia coli correlated with the haemolytic activity of the strains (r = 0.572, P less than 0.01). LTB4 generation by human neutrophils (PMN... | ['Adenosine Triphosphate', 'Arachidonic Acid', 'Arachidonic Acids', 'Escherichia coli', 'Hemolysis', 'Humans', 'L-Lactate Dehydrogenase', 'Leukotriene B4', 'Lymphocyte Activation', 'Monocytes', 'Neutrophils'] | 2,159,346 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Successful treatment and digestive decolonisation of a patient with osteitis caused by a carbapenemase-producing Klebsiella pneumoniae isolate harbouring both NDM-1 and OXA-48 enzymes. | OBJECTIVES: Carbapenem resistance in Klebsiella pneumoniae is an increasing problem worldwide and infections caused by this bacterium can be difficult to treat. This study reported the case of a patient from Romania, who was hospitalised in Bulgaria after an accident trauma. He then came to France for treatment of an o... | ['Adult', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Carbapenems', 'Drug Resistance, Multiple, Bacterial', 'Fecal Microbiota Transplantation', 'Humans', 'Klebsiella pneumoniae', 'Male', 'Microbial Sensitivity Tests', 'Osteitis', 'Plasmids', 'Whole Genome Sequencing', 'beta-Lactamases'] | 31,201,994 | [['M01.060.116'], ['D27.505.954.122.085'], ['D12.776.097'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['E02.095.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.450.425.425.600', 'B03.660.250.150.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Anesthesia for argon plasma coagulation therapy through the tracheostomy site]. | We experienced a case of argon plasma coagulation (APC) therapy for bronchial obstruction. A 54-year-old man was scheduled for APC therapy for bronchial obstruction using bronchoscope via a tracheostoma. The patient had received left upper lobectomy four years before and laryngectomy and tracheotomy two years before. A... | ['Anesthesia', 'Argon', 'Bronchial Diseases', 'Bronchoscopy', 'Constriction, Pathologic', 'Humans', 'Laser Therapy', 'Male', 'Middle Aged', 'Tracheostomy'] | 16,296,370 | [['E03.155'], ['D01.268.613.050', 'D01.362.641.113'], ['C08.127'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['C23.300.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['E02.041.750', 'E04.579.935', 'E04.580.900', 'E04.928.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Weaning Unit of the University Medicine Greifswald - Institutional Structure and Weaning Results from Prolonged Ventilation over 10 Years]. | The increasing importance of intensive care medicine including mechanical ventilation has been accompanied by the demand of weaning opportunities for patients undergoing prolonged mechanical ventilation. Consequently, specialised clinical institutions, focusing on the weaning from mechanical ventilation, have been esta... | ['Aged', 'Female', 'Germany', 'Hospital Units', 'Hospitals, University', 'Humans', 'Intensive Care Units', 'Long-Term Care', 'Male', 'Middle Aged', 'Pneumonia', 'Sepsis', 'Survival Rate', 'Ventilator Weaning'] | 28,505,685 | [['M01.060.116.100'], ['Z01.542.315'], ['N02.278.388'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['E02.760.476', 'N02.421.585.476'], ['M01.060.116.630'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['C01.757', 'C23.550.470.790.500'], ['E05.... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Social isolation stress significantly enhanced the disruption of prepulse inhibition in mice repeatedly treated with methamphetamine. | Repeated administration of methamphetamine (METH) causes reverse tolerance or behavioral sensitization in mice. However, the effects of social isolation stress on the METH-caused reverse tolerance have not been studied until now. The aim of this study was to investigate the effects of social isolation stress on METH-ca... | ['Animals', 'Locomotion', 'Male', 'Methamphetamine', 'Mice', 'Mice, Inbred C57BL', 'Reflex, Startle', 'Social Isolation', 'Stress, Physiological'] | 15,542,725 | [['B01.050'], ['G07.568.500', 'G11.427.410.568'], ['D02.092.471.683.152.619'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E01.370.376.550.650.800', 'E01.370.600.550.650.800', 'F02.830.702.807', 'G11.561.731.869'], ['F01.145.813.781'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
The scaffold protein POSH regulates axon outgrowth. | How scaffold proteins integrate signaling pathways with cytoskeletal components to drive axon outgrowth is not well understood. We report here that the multidomain scaffold protein Plenty of SH3s (POSH) regulates axon outgrowth. Reduction of POSH function by RNA interference (RNAi) enhances axon outgrowth in differenti... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Axons', 'Cells, Cultured', 'Cerebral Cortex', 'Cytoskeletal Proteins', 'Genetic Complementation Test', 'Humans', 'Mice', 'Microfilament Proteins', 'Neurons', 'Nonmuscle Myosin Type IIA', 'Protein Isoforms', 'Protein Structure, Tertiary', 'RNA Interference', 'Two-Hybr... | 18,829,867 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['D12.776.220'], ['E05.393.281.526'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Evaluation of autopsy cases in pancreatic cancer]. | The incidence of pancreatic cancer has increased recently. The average age of pancreatic cancer patients in our series was 60.6 years; the male to female ratio was 2.3:1. As for tumor location, the head (45.5%) was the most frequent followed by the body (32.7%) and the tail (20%). Pancreatic cancers were histologically... | ['Adult', 'Age Factors', 'Aged', 'Female', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Pancreatic Neoplasms'] | 6,663,709 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Potential trace metal-organic complexation in the atmosphere. | It is possible that metal-organic complexation enhances the uptake of gaseous organic compounds and the solubility of metals in aerosols and atmospheric water. We investigated potential atmospheric organic ligands and the enhanced uptake of hydroxy-, oxo-, and dicarboxylic acids as well as dicarbonyls into atmospheric ... | ['Aerosols', 'Atmosphere', 'Dicarboxylic Acids', 'Gases', 'Glyoxal', 'Ligands', 'Metals', 'Nitrogen Compounds', 'Organic Chemicals', 'Pyruvaldehyde', 'Solubility', 'Water'] | 12,806,002 | [['D20.280.055', 'D26.255.165.055'], ['G16.500.275.063', 'N06.230.300.100'], ['D02.241.081.337'], ['D01.362'], ['D02.047.644'], ['D27.720.470.480'], ['D01.552'], ['D01.625'], ['D02'], ['D02.047.644.650'], ['G02.805'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus. | Molecular modification is a quite promising strategy in the design and development of drug analogs with better bioavailability, higher intrinsic activity and less toxicity. In the search of new leads with potential antimicrobial activity, a new series of 14 4-substituted [N'-(benzofuroxan-5-yl)methylene]benzohydrazides... | ['Anti-Infective Agents', 'Benzoxazoles', 'Drug Design', 'Hydroxybenzoates', 'Microbial Sensitivity Tests', 'Models, Molecular', 'Nitrofurans', 'Staphylococcus aureus', 'Structure-Activity Relationship'] | 19,324,556 | [['D27.505.954.122'], ['D03.633.100.221'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D02.241.223.100.300', 'D02.241.511.390', 'D02.455.426.559.389.127.281', 'D02.455.426.559.389.657.410'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E05.599.595'], ['D02.640.600', 'D03.383... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Plasma catecholamine concentrations in hyperthyroidism and hypothyroidism. | Using a modification of the fluorometric method of Anton and Sayre, we have measured the plasma epinephrine (E) and norepinephrine (NE) concentrations in patients with thyroid dysfunction. There was no significant difference in plasma E in hyperthyroid or hypothyroid subjects, the values being similar to those observed... | ['Age Factors', 'Epinephrine', 'Humans', 'Hyperthyroidism', 'Hypothyroidism', 'Norepinephrine', 'Thyroxine', 'Triiodothyronine'] | 958,003 | [['N05.715.350.075', 'N06.850.490.250'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.397'], ['C19.874.482'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', '... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Purification of GFP fusion proteins with high purity and yield by monoclonal antibody-coupled affinity column chromatography. | GFP has often been used as a marker of gene expression, protein localization in living and fixed tissues as well as for protein targeting in intact cells and organisms. Monitoring foreign protein expression via GFP fusion is also very appealing for bioprocess applications. Many cells, including bacterial, fungal, plant... | ['Animals', 'Antibodies, Monoclonal', 'Blotting, Western', 'CHO Cells', 'Chromatography, Affinity', 'Cricetinae', 'Cricetulus', 'Gene Products, tat', 'Green Fluorescent Proteins', 'Recombinant Fusion Proteins'] | 18,342,538 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.200', 'A11.436.155'], ['E05.196.181.400.170'], ['B01.050.150.900.649.313.992.635.075.250'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intraoperative doppler ultrasound: a reliable diagnostic method in insulinoma. | A 44-year-old woman was admitted with obvious symptoms of hypoglycemia and Whipple's triad during a 6-month period. The glucose level was as low as 32 mg/dL and insulin/glucose ratio greater than 0.5 after fasting. Abdominal magnetic resonance imaging (MRI) studies revealed a pancreatic mass at the head, 2 cm in diamet... | ['Adult', 'Diagnosis, Differential', 'Female', 'Humans', 'Insulinoma', 'Intraoperative Care', 'Laparotomy', 'Pancreatectomy', 'Pancreatic Neoplasms', 'Ultrasonography, Doppler'] | 17,629,082 | [['M01.060.116'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.470.035.100.852', 'C04.588.274.761.249.500', 'C04.588.322.475.249.500', 'C06.301.761.249.500', 'C06.689.667.249.500', 'C19.344.421.249.500'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['E04.406'], ['E04.210.752'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Central activation and peripheral function of sympatho-adrenal and cardiovascular systems in the Zucker rat. | Electrical stimulation of the hypothalamus in anesthetized lean and obese Zucker rats produced equivalent activation of the sympatho-adrenal system (assessed by plasma norepinephrine [NE] and epinephrine [E] levels) and cardiovascular systems (assessed by monitoring intra-arterial blood pressure and heart rate). Basal ... | ['Adrenal Glands', 'Animals', 'Blood Pressure', 'Cardiovascular System', 'Dihydroalprenolol', 'Electric Stimulation', 'Epinephrine', 'Heart Rate', 'Isoproterenol', 'Male', 'Norepinephrine', 'Obesity', 'Rats', 'Rats, Mutant Strains', 'Rats, Zucker', 'Receptors, Adrenergic, beta', 'Sympathetic Nervous System', 'Ventromed... | 6,326,172 | [['A06.300.071'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07'], ['D02.033.100.624.698.055.200', 'D02.033.755.624.698.055.200', 'D02.092.063.624.698.055.200'], ['E05.723.402'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.46... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. | The cytokines IL-4 and IL-13 inhibit the production of NO from activated macrophages through an unresolved molecular mechanism. We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS). Inhibition of NO production from murine macrophages stimul... | ['Animals', 'Arginase', 'Arginine', 'Cells, Cultured', 'Down-Regulation', 'Interleukin-13', 'Interleukin-4', 'Macrophage Activation', 'Macrophages, Peritoneal', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type II', 'STAT6 Transcription Factor', 'Substr... | 11,160,269 | [['B01.050'], ['D08.811.277.913.292'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.644.276.374.465.513', 'D12.776.467.374.465.513', 'D23.529.374.465.513'], ['D12.644.276.374.465.186', 'D12.776.467.374.465.178', 'D23.529.374.465.186'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative clinical study on deformity correction accuracy of different external fixators. | PURPOSE: In this study, the correction accuracy of Smart Correction spatial fixators and of Ilizarov-type external fixators are compared in terms of deformity complexity.METHODS: Seventy-seven (40 male, 37 female) bone segments of 57 patients treated with a Smart Correction device were compared with 94 (51 male, 43 fem... | ['Adolescent', 'Adult', 'Bone Lengthening', 'Child', 'Congenital Abnormalities', 'External Fixators', 'Female', 'Follow-Up Studies', 'Humans', 'Ilizarov Technique', 'Leg Bones', 'Male', 'Orthopedic Procedures', 'Treatment Outcome', 'Wounds and Injuries', 'Young Adult'] | 24,068,442 | [['M01.060.057'], ['M01.060.116'], ['E04.555.120'], ['M01.060.406'], ['C16.131'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.120.380', 'E04.555.300.380'], ['A02.835.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. | Ataxia telangiectasia (A-T) is a rare autosomal recessive disorder characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immune defects and predisposition to malignancies. A-T is caused by biallelic inactivation of the ATM gene, in most cases by frameshift or nonsense mutations. More rarely, AT... | ['Ataxia Telangiectasia', 'Ataxia Telangiectasia Mutated Proteins', 'Cell Cycle Proteins', 'Cell Line', 'Child', 'Child, Preschool', 'DNA-Binding Proteins', 'Female', 'Gene Expression', 'Histones', 'Humans', 'Infant', 'Male', 'Mutation, Missense', 'Phosphorylation', 'Polymorphism, Single Nucleotide', 'Protein Transport... | 22,071,889 | [['C10.228.140.252.190.530.060', 'C10.562.100', 'C10.597.350.090.500.530.060', 'C14.907.823.213', 'C16.320.080', 'C16.320.798.250', 'C18.452.284.060', 'C20.673.795.250'], ['D08.811.913.696.620.682.700.097', 'D12.776.157.687.125', 'D12.776.660.720.125'], ['D12.776.167'], ['A11.251.210'], ['M01.060.406'], ['M01.060.406.4... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new autosomal recessive anomaly mimicking Fanconi's anaemia phenotype. | A family in which three siblings born to related parents all manifested clinical abnormalities characteristic of Fanconi's anaemia (microcephaly, short stature, slow growth, beak nose, micrognathia, skin dyspigmentation and forearm and thumb dysplasia in 2/3) is reported. All five family members had normal spontaneous ... | ['Abnormalities, Multiple', 'Child', 'Child, Preschool', 'Chromosome Fragility', 'Chromosome Mapping', 'Epoxy Compounds', 'Fanconi Anemia', 'Female', 'Genes, Recessive', 'Growth Disorders', 'Humans', 'Infant', 'Male', 'Pedigree', 'Syndrome'] | 8,434,992 | [['C16.131.077'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.210.110.180', 'C23.550.362.180.180', 'G05.365.590.175.165.180', 'G05.370.180.180'], ['E05.393.183'], ['D02.355.291.411'], ['C15.378.071.085.080.280', 'C15.378.190.223.500.500.280', 'C16.320.077.280', 'C18.452.284.280'], ['G05.360.340.024.340.415', 'G05.4... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. | Oncogenic stress-induced senescence (OIS) prevents the ability of oncogenic signals to induce tumorigenesis. It is now largely admitted that the mitogenic effect of oncogenes requires metabolic adaptations to respond to new energetic and bio constituent needs. Yet, whether glucose metabolism affects OIS response is lar... | ['Cells, Cultured', 'Cellular Senescence', 'Energy Metabolism', 'Enzyme Inhibitors', 'Epithelial Cells', 'Female', 'Glucose', 'Glucose-6-Phosphate', 'Glycolysis', 'Hexokinase', 'Hexosamines', 'Humans', 'Kinetics', 'Mammary Glands, Human', 'Oncogenes', 'Pentose Phosphate Pathway', 'Time Factors', 'Transfection'] | 24,577,087 | [['A11.251'], ['G04.043'], ['G03.295'], ['D27.505.519.389'], ['A11.436'], ['D09.947.875.359.448'], ['D09.894.417.448.500'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['D08.811.913.696.620.300'], ['D09.067.342'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['A... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion. | Investigation into the interactions between graphene oxide (GO) and biomolecules is very important for broad applications of GO in bioassay and bioanalysis. In this work, we describe the interactions between double-stranded DNA (dsDNA) and GO. We demonstrated that dsDNA can bind to GO forming complexes (dsDNA/GO) in th... | ['Adsorption', 'DNA', 'Deoxyribonuclease I', 'Deoxyribonucleases, Type II Site-Specific', 'Endodeoxyribonucleases', 'Enzymes', 'Graphite', 'Nanostructures', 'Octoxynol', 'Oxides'] | 21,829,836 | [['G01.030', 'G02.020'], ['D13.444.308'], ['D08.811.277.352.335.350.250'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['D08.811'], ['D01.268.150.300', 'D01.578.300'], ['J01.637.512'], ['D02.033.455.250.700.660', ... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Effect of vagotomy on gastrin secretion in patients with duodenal ulcer]. | The basal and food-stimulated gastrin secretion after selective proximal vagotomy, selective gastric vagotomy and truncular vagotomy was found to be elevated. Hypergastrinemia increased as gastric secretion was inhibited, thus attesting to the role of acid formation inhibition in the origin of the postvagotomy increase... | ['Adult', 'Duodenal Ulcer', 'Eating', 'Female', 'Gastrins', 'Humans', 'Male', 'Middle Aged', 'Postoperative Period', 'Pyloric Antrum', 'Time Factors', 'Vagotomy', 'Vagotomy, Proximal Gastric'] | 4,002,123 | [['M01.060.116'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['G07.203.650.283', 'G10.261.330'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['A... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diagnostic efficacy of Aldehyde test in late cases of Kala-azar. | This case control study was carried out in the Paediatric wards of Mymensingh Medical College Hospital for a period of one year from April 2002 to March 2003 to determine the sensitivity, specificity and predictive values of Aldehyde test in the diagnosis of Kala-azar. A total of seventy five febrile cases of Kala-azar... | ['Aldehydes', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Leishmaniasis, Visceral', 'Male', 'Predictive Value of Tests', 'Serologic Tests'] | 17,703,152 | [['D02.047'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.610.752.300.500.510', 'C01.920.813.510'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E01.370.225.812.735', 'E05.200.812.735', 'E05.478.594.760']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Acute myocardial infarction with simultaneous occlusions of two coronary arteries in a 44 year-old man]. | Simultaneous thrombosis of multiple epicardial coronary arteries is an uncommon clinical finding in ST-segment elevation myocardial infarction (STEMI). We describe a 44 year-old male present with STEMI who was found to have simultaneously occluded two epicardial arteries. There is many clinical states that can lead to ... | ['Adult', 'Arginine', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Thrombosis', 'Dietary Supplements', 'Electrocardiography', 'Humans', 'Male', 'Myocardial Infarction'] | 23,575,785 | [['M01.060.116'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['G... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro. | Transforming growth factor type beta (TGF-beta) suppresses basal as well as corticotropin (ACTH)-stimulated steroid formation by bovine adrenocortical cells in culture. The effect is dose dependent and is not accompanied by any change in adrenocortical cell growth. The minimum effective dose of TGF-beta is 4 X 10(-13) ... | ['Adrenal Cortex', 'Adrenal Cortex Hormones', 'Adrenocorticotropic Hormone', 'Cells, Cultured', 'Cholesterol', 'Cyclic AMP', 'Growth Substances', 'Peptides', 'Transforming Growth Factors'] | 3,020,557 | [['A06.300.071.140'], ['D06.472.040'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['A11.251'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.... | ['Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The systemic model of crime and institutional efficacy: an analysis of the social context of offender reintegration. | The systemic model of crime has received considerable empirical attention from criminologists; yet, an often-neglected component of the theoretical framework is the role of social institutions as a source of both formal and informal social control. Accordingly, the current study builds on recent research that considers... | ['Anomie', 'Community Integration', 'Crime', 'Efficiency, Organizational', 'Halfway Houses', 'Homicide', 'Humans', 'Juvenile Delinquency', 'Models, Psychological', 'Poverty Areas', 'Prisoners', 'Program Development', 'Psychosocial Deprivation', 'Risk Factors', 'Secondary Prevention', 'Social Control, Formal', 'Social C... | 22,009,218 | [['F01.145.813.093', 'I01.880.853.450.283'], ['I01.880.787.354'], ['I01.198.240', 'I01.880.735.191'], ['N04.452.209.500'], ['J03.775.450'], ['I01.198.240.470', 'I01.880.735.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.479'], ['E05.599.695'], ['I01.880.853.996.535.550', 'N01.824.600.550'], ['M01... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Build-up of the tendency to segregate auditory streams: resetting effects evoked by a single deviant tone. | The tendency to hear a sequence of alternating low (L) and high (H) frequency tones as two streams can be increased by a preceding induction sequence, even one composed only of same-frequency tones. Four experiments used such an induction sequence (10 identical L tones) to promote segregation in a shorter test sequence... | ['Acoustic Stimulation', 'Humans', 'Pitch Discrimination', 'Sound Localization', 'Time Perception'] | 21,110,597 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.071.700.408', 'G07.888.125.700.408'], ['F02.463.593.071.869', 'G07.888.125.869'], ['F02.463.593.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
State-Identified Implementation Strategies to Increase Uptake of Immediate Postpartum Long-Acting Reversible Contraception Policies. | BACKGROUND: In 2014, the Association of State and Territorial Health Officials (ASTHO) convened a multistate Immediate Postpartum Long-Acting Reversible Contraception (LARC) Learning Community to facilitate cross-state collaboration in implementation of policies. The Learning Community model was based on systems change... | ['Female', 'Health Education', 'Health Plan Implementation', 'Health Policy', 'Humans', 'Long-Acting Reversible Contraception', 'Medicaid', 'Postpartum Period', 'Pregnancy', 'United States'] | 30,388,052 | [['I02.233.332', 'N02.421.726.407'], ['N03.349.300'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.875.194.589'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['G08.686.702'], ['G08.686.784.769'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Setting up a scientific community by means of a small grants program: the Latin American experience. | The study of tropical diseases in Latin America has been dominated by the biomedical sciences, and whilst recently social science health research has been developed, there has been little collaboration between the two. The Latin American Small Grants Programme for Social and Economic Aspects of Tropical Diseases, launc... | ['Financing, Organized', 'Humans', 'Latin America', 'Organizational Objectives', 'Social Sciences', 'Tropical Medicine', 'World Health Organization'] | 7,985,553 | [['N03.219.521'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.424'], ['N04.452.615'], ['F04.096.879', 'I01'], ['H02.403.879'], ['N03.540.514.718.800']] | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. | Eiken syndrome is a rare autosomal recessive skeletal dysplasia. We identified a truncation mutation in the C-terminal cytoplasmic tail of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) type 1 receptor (PTHR1) gene as the cause of this syndrome. Eiken syndrome differs from Jansen and Blomstrand chondrodyspla... | ['Amino Acid Sequence', 'Bone Diseases, Developmental', 'Enchondromatosis', 'Exostoses, Multiple Hereditary', 'Female', 'Genes, Recessive', 'Humans', 'Male', 'Pedigree', 'Receptor, Parathyroid Hormone, Type 1', 'Sequence Deletion'] | 15,525,660 | [['G02.111.570.060', 'L01.453.245.667.060'], ['C05.116.099'], ['C05.116.099.708.338'], ['C04.557.450.565.575.610.615.325', 'C04.700.330', 'C05.116.099.708.670.615.325', 'C05.116.540.310.500', 'C16.320.700.330'], ['G05.360.340.024.340.415', 'G05.420.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Dual redox and thermoresponsive double hydrophilic block copolymers with tunable thermoresponsive properties and self-assembly behavior. | The synthesis, tunable thermoresponsive properties, and self-assembly of dual redox and thermoresponsive double hydrophilic block copolymers having pendant disulfide linkages (DHBCss) are reported. Well-defined DHBCss composed of a hydrophilic poly(ethylene oxide) block and a dual thermo- and reduction-responsive rando... | ['Hydrophobic and Hydrophilic Interactions', 'Molecular Structure', 'Oxidation-Reduction', 'Particle Size', 'Polymers', 'Surface Properties', 'Temperature'] | 24,497,107 | [['G02.409'], ['G02.111.570', 'G02.466'], ['G02.700', 'G03.295.531'], ['G02.712'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility. | Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental ging... | ['Adolescent', 'Adult', 'Amino Acids', 'Biological Assay', 'Case-Control Studies', 'Cell Line', 'Diglycerides', 'Disease Susceptibility', 'Epithelial Cells', 'Erythritol', 'Female', 'Gingiva', 'Gingivitis', 'Hemorrhage', 'Host-Pathogen Interactions', 'Humans', 'Male', 'Metabolome', 'Middle Aged', 'Plasmalogens', 'Re-Ep... | 32,080,300 | [['M01.060.057'], ['M01.060.116'], ['D12.125'], ['E05.091'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210'], ['D10.351.303'], ['C23.550.291.687', 'G07.100.250'], ['A11.436'], ['D02.033.800.329', 'D09.853.329'], ['A14.549.167.646.480'], ['C01.408', 'C07.465.714.258.480'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Carotid artery intima-media thickness in hypertensive patients with obstructive sleep apnea. | In this study we determined the relationship between the severity of obstructive sleep apnea (OSA) and body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), and carotid intima-media thickness (cIMT) in 30 hypertensive male patients, aged 30-70, with newly diagnosed OSA (15 with moderate OSA - Group A... | ['Adult', 'Aged', 'Blood Pressure', 'Body Mass Index', 'Carotid Artery, Common', 'Carotid Intima-Media Thickness', 'Case-Control Studies', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Polysomnography', 'Risk Factors', 'Sleep Apnea, Obstructive'] | 25,315,618 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['A07.015.114.186.200'], ['E01.370.350.850.150', 'E01.370.370.180', 'G09.330.210'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. | O(6)-Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin cytotoxicity in vitro. The aim of this study was to investigate the mechanism of cisplatin potentiation by NU2058. SQ20b, head and neck cancer cells were treated for 2h with NU2058 (100 microM) a... | ['Antineoplastic Agents', 'Blotting, Western', 'Cell Line, Tumor', 'Cell Survival', 'Cisplatin', 'Cyclin-Dependent Kinase 2', 'DNA Adducts', 'Drug Synergism', 'Guanine', 'Humans', 'Protein Kinase Inhibitors', 'Tumor Stem Cell Assay'] | 19,426,695 | [['D27.505.954.248'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D08.811.913.696.620.682.700.646.500.750', 'D12.644.360.250.323', 'D12.776.167.200.323', 'D12.77... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improving access for the poorest to public sector health services: insights from Kirivong Operational Health District in Cambodia. | This article presents research findings into the effectiveness of an innovative equity fund approach to improving access to public sector health services for the poor in Kirivong Operational Health District in Cambodia. The operational health district is the lowest organizational level in the Cambodian health system, p... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cambodia', 'Cross-Sectional Studies', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Poverty', 'Public Sector'] | 16,293,700 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.252.145.182'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.880.735.634', 'I01.880.853.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 2). | Previously, we reported that a methanol extract (500 mg/kg x 2/day) of the heartwood of Cassia garrettiana inhibited the tumor growth and metastasis to the lung in Lewis lung carcinoma (LLC)-bearing mice. Furthermore, we isolated the two active substances from the methanol extract of C. garrettiana and identified compo... | ['Acetylation', 'Angiogenesis Inhibitors', 'Animals', 'Antineoplastic Agents', 'Carcinoma, Lewis Lung', 'Cassia', 'Cell Line', 'Endothelium, Vascular', 'Female', 'Humans', 'Lung Neoplasms', 'Mice', 'Mice, Inbred C57BL', 'Molecular Structure', 'Neoplasm Metastasis', 'Plant Extracts', 'Plants, Medicinal', 'Stilbenes', 'S... | 11,062,702 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D27.505.954.248'], ['C04.557.470.200.280', 'C04.619.230'], ['B01.650.940.800.575.912.250.401.100'], ['A11.251.210'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Security Audit Center--a suggested model for effective audit strategies in health care informatics. | As dependence upon interorganizational and international health care informatics becomes absolute, and with increased vulnerability of information networks and applications and the cunning sophistication of computer criminals, it becomes imperative to implement tight information systems security to ward off any possibl... | ['Automation', 'Computer Communication Networks', 'Computer Security', 'Computer Systems', 'Computers', 'Confidentiality', 'Database Management Systems', 'Expert Systems', 'Forms and Records Control', 'Health Services', 'Information Systems', 'Models, Theoretical', 'Organizational Policy', 'Risk Management', 'Security ... | 8,188,404 | [['J01.897.104'], ['L01.224.230.110'], ['L01.224.134', 'N04.452.910.200'], ['L01.224.230'], ['L01.224.230.260'], ['F04.096.544.335.240', 'I01.880.604.473.650.500', 'I01.880.604.583.080', 'N03.706.437.650.124', 'N03.706.535.230'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.224.050.375.190'], ['N04.452.... | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain. | Acetylcholine receptor channel gating is a brownian conformational cascade in which nanometer-sized domains ("Phi blocks") move in staggering sequence to link an affinity change at the transmitter binding sites with a conductance change in the pore. In the alpha-subunit, the first Phi-block to move during channel openi... | ['Acetylcholine', 'Animals', 'Electrophysiology', 'Extracellular Space', 'Ion Channel Gating', 'Kinetics', 'Membrane Potentials', 'Models, Molecular', 'Molecular Conformation', 'Mutagenesis', 'Mutation', 'Peptide Fragments', 'Receptors, Nicotinic', 'Structure-Activity Relationship', 'Torpedo'] | 18,040,059 | [['D02.092.211.111'], ['B01.050'], ['H01.158.344.528', 'H01.158.782.236'], ['A10.082.500', 'A11.284.295'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['G01.374.661', 'G02.111.490'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.595'], ['G02.111.570.820'], ['G05.558'], ['G05.365.590'], ['D1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
N-of-1 Trials for Closed-Loop Deep Brain Stimulation Devices. | Closed-loop deep brain stimulation (DBS) devices hold great promise for treating various neurological and psychiatric conditions. Yet while these algorithmic-based devices provide personalized treatment to each patient, they also present uniquely individualized risks of physiological and psychological harms. These expe... | ['Brain', 'Clinical Trials as Topic', 'Deep Brain Stimulation', 'Equipment Design', 'Humans', 'Precision Medicine', 'Stereotaxic Techniques'] | 32,233,116 | [['A08.186.211'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E02.331.300', 'E04.190'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.782', 'H02.403.200.700'], ['E04.525.800', 'E05.873']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of therapeutic vaccines by direct modification of cell membranes from surgically removed human tumor tissue with immunostimulatory molecules. | The addition of immunostimulatory molecules to tumor cells has been proposed as a potentially useful strategy to induce anti-tumor immunity. In this report we have investigated the application of using isolated tumor membranes modified by transfer of a glycosyl-phosphatidylinositol (GPI)-anchored form of the costimulat... | ['Adjuvants, Immunologic', 'Animals', 'B7-1 Antigen', 'CHO Cells', 'Cancer Vaccines', 'Cell Membrane', 'Cricetinae', 'Glycosylphosphatidylinositols', 'Humans', 'In Vitro Techniques', 'Lymphocyte Activation', 'Neoplasms', 'T-Lymphocytes', 'Tumor Cells, Cultured'] | 11,228,374 | [['D27.505.696.477.067'], ['B01.050'], ['D12.776.467.150.100', 'D12.776.543.095.100', 'D23.050.301.285.100', 'D23.529.168.100'], ['A11.251.210.200', 'A11.436.155'], ['D20.215.894.200'], ['A11.284.149'], ['B01.050.150.900.649.313.992.635.075.250'], ['D09.400.410.475', 'D10.390.475', 'D10.570.755.375.760.400.942.250'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
'Do it yourself' sexual health care: the user experience. | OBJECTIVES: To describe client experience of self-management within a busy walk-in, sexual health service. Self-management in this context is self-registration and take-home pregnancy tests, chlamydia (Chlamydia trachomatis) and gonorrhoea (Neisseria gonorrhoeae) tests, or condoms dispensed from a free vending machine.... | ['Ambulatory Care Facilities', 'Chlamydia Infections', 'Condoms', 'Gonorrhea', 'Health Services Accessibility', 'Humans', 'London', 'Outcome Assessment, Health Care', 'Patient Acceptance of Health Care', 'Patient Satisfaction', 'Self Care', 'Self Efficacy', 'State Medicine'] | 21,371,379 | [['N02.278.035'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['E07.190.270.150'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01.778.281.401', 'C12.294.668.281.401', 'C13.351.500.711.281.... | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
[Inhalation of an extract from the leaf buds of the deltoid poplar during the early period following tonsillectomy]. | To prevent inflammatory processes in the mucous membrane of the upper respiratory tract during early periods after tonsillectomy (2-7 days) the authors practiced inhalations of the extract of Eastern poplar leaf buds in 40 patients with chronic tonsillitis after the operation. The use of the extract of Eastern poplar l... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Inflammation', 'Male', 'Middle Aged', 'Plant Extracts', 'Postoperative Care', 'Postoperative Complications', 'Tonsillectomy', 'Trees'] | 983,316 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['M01.060.116.630'], ['D20.215.784.500', 'D26.667'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['C23.550.767'], ['E04.580.848'], ['B01.650.915']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Late clotted haemothorax after blunt chest trauma. | A clotted haemothorax can develop any time after blunt chest trauma. Two cases are described in which late clotted haemothoraces developed which were treated by limited thoracotomy and evacuation of clots. Late clotted haemothorax may occur even in the absence of any abnormal initial clinical findings. Early detection ... | ['Accidental Falls', 'Adult', 'Aged', 'Disease-Free Survival', 'Hemothorax', 'Humans', 'Male', 'Radiography', 'Rib Fractures', 'Thoracotomy', 'Thrombosis', 'Wounds, Nonpenetrating'] | 9,639,184 | [['N06.850.135.122'], ['M01.060.116'], ['M01.060.116.100'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['C08.528.380', 'C23.550.414.904'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700']... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Superficial femoral artery stent fracture that led to perforation, hematoma and deep venous thrombosis. | We describe the case of a 70-year old male with total occlusion of the left superficial femoral artery (SFA) treated with percutaneous implantation of a self-expanding nitinol stent. The patient's course post-stent implantation was complicated by the development of stent fracture with SFA perforation and a large, compr... | ['Aged', 'Angioplasty, Balloon', 'Equipment Failure', 'Femoral Artery', 'Hematoma', 'Humans', 'Male', 'Rupture', 'Stents', 'Venous Thrombosis'] | 18,762,680 | [['M01.060.116.100'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['E05.325'], ['A07.015.114.351'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.761'], ['E07.695.750'], ['C14.907.355.830.925']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Toxoplasma gondii abortion storm in sheep on a Texas farm and isolation of mouse virulent atypical genotype T. gondii from an aborted lamb from a chronically infected ewe. | Sheep are commonly infected with the protozoan parasite, Toxoplasma gondii. Infection may cause early embryonic death and resorption, fetal death and mummification, abortion, stillbirth, and neonatal death. Most sheep acquire T. gondii infection after birth. Recent studies reported that congenital ovine transmission of... | ['Aborted Fetus', 'Abortion, Veterinary', 'Agglutination Tests', 'Animals', 'Antibodies, Protozoan', 'Encephalitis', 'Female', 'Genotype', 'Mice', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Pregnancy', 'Sheep', 'Sheep Diseases', 'Texas', 'Toxoplasma', 'Toxoplasmosis, Animal', 'Virulence'... | 23,099,088 | [['A16.378.099'], ['C13.703.039.422', 'C22.021'], ['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['C10.228.140.430'], ['G05.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.39... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment. | In response to various inflammatory stimuli, neutrophils secrete neutrophil extracellular traps (NETs), web-like meshworks of DNA, histones and granular components forming supplementary scaffolds in venous and arterial thrombi. Isolated DNA and histones are known to promote thrombus formation and render fibrin clots mo... | ['DNA', 'Deoxyribonuclease I', 'Extracellular Traps', 'Fibrin', 'Fibrinolysis', 'Histones', 'Humans', 'Kinetics', 'Microscopy, Confocal', 'Microscopy, Electron, Scanning', 'Neutrophil Activation', 'Neutrophils', 'Permeability', 'Plasma', 'Plasminogen', 'Tetradecanoylphorbol Acetate', 'Thrombin', 'Tissue Plasminogen Act... | 25,789,443 | [['D13.444.308'], ['D08.811.277.352.335.350.250'], ['A11.284.295.495'], ['D12.776.124.270'], ['G09.188.390.150.390'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides. | 1. Permethylation and g.l.c.-mass spectrometric analysis of bile from an isolated rat liver perfusion to which methocarmol was added showed seven components not present in control bile: methocarbamol, glucuronides of methocarbamol and desmethyl-methocarbamol, and four glucuronides of hydroxylated methocarbamol metaboli... | ['Animals', 'Bile', 'Chemical Phenomena', 'Chemistry', 'Chromatography, Gas', 'Glucuronates', 'Liver', 'Mass Spectrometry', 'Methocarbamol', 'Perfusion', 'Rats'] | 1,166,662 | [['B01.050'], ['A12.200.087'], ['G02'], ['H01.181'], ['E05.196.181.349'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['A03.620'], ['E05.196.566'], ['D02.241.081.251.583.577', 'D02.355.601.536.400.500', 'D02.355.726.453.400.500', 'D02.455.426.559.389.657.654.453.400... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Global warming factor of municipal solid waste management in Europe. | The global warming factor (GWF; CO(2)-eq. tonne(-1) waste) performance of municipal waste management has been investigated for six representative European Member States: Denmark, France, Germany, Greece, Poland and the United Kingdom. The study integrated European waste statistical data for 2007 in a life-cycle assessm... | ['Air Pollutants', 'Air Pollution', 'Carbon Dioxide', 'Cities', 'Denmark', 'France', 'Germany', 'Global Warming', 'Greece', 'Models, Statistical', 'Poland', 'Refuse Disposal', 'United Kingdom', 'Waste Management', 'Waste Products'] | 19,808,730 | [['D27.888.284.101'], ['N06.850.460.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['Z01.542.816.124'], ['Z01.542.286'], ['Z01.542.315'], ['G16.500.175.374.500'], ['Z01.542.383'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Safety evaluation of Bacillus coagulans SNZ 1969 in Wistar rats. | Bacillus coagulans SNZ 1969 is a rod-shaped, slightly acidophilic, gram-positive, spore forming and highly resilient bacteria. B. coagulans SNZ 1969 has GRAS (Generally Recognized As Safe) status for use as a probiotic in foods (US FDA number GRN-597). The present study was aimed to assess the safety of a proprietary s... | ['Animals', 'Bacillus coagulans', 'Female', 'Food Additives', 'Lethal Dose 50', 'Male', 'No-Observed-Adverse-Effect Level', 'Probiotics', 'Rats, Wistar', 'Toxicity Tests, Acute', 'Toxicity Tests, Subacute'] | 31,751,640 | [['B01.050'], ['B03.300.390.400.158.218.314', 'B03.353.500.100.218.314', 'B03.510.100.100.218.314', 'B03.510.415.400.158.218.314', 'B03.510.460.410.158.218.314'], ['D27.720.372.300', 'G07.203.300.514.500', 'J02.500.514.500'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['E05.940.600', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
PTH 1-34 loaded thiolated chitosan nanoparticles for osteoporosis: oral bioavailability and anabolic effect on primary osteoblast cells. | In this work, biocompatible and mucoadhesive thiolated chitosan (TCS) was used in the preparation of oral nanoformulation of human parathyroid hormone 1-34 (PTH 1-34) as an alternative patient compliant route in treating osteoporosis. PTH 1-34 loaded thiolated chitosan nanoparticles (TCS-PTH 1-34 NPs) size, morphology ... | ['Administration, Oral', 'Anabolic Agents', 'Animals', 'Biological Availability', 'Bone Density Conservation Agents', 'Chitosan', 'Drug Carriers', 'Drug Evaluation, Preclinical', 'Female', 'Humans', 'Nanoparticles', 'Osteoblasts', 'Osteoporosis', 'Parathyroid Hormone', 'Rats', 'Rats, Sprague-Dawley', 'Sulfhydryl Compou... | 24,724,508 | [['E02.319.267.100'], ['D27.505.696.399.472.080'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['D27.505.696.242'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D26.255.260', 'E02.319.300.380'], ['E05.290.750', 'E05.337.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['A11.329.629'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Does Media Literacy Mitigate Risk for Reduced Body Satisfaction Following Exposure to Thin-Ideal Media? | Exposure to thin-ideal media can contribute to increased body dissatisfaction in adolescent girls. Understanding the factors that may prevent or exacerbate the negative effects of media exposure on body dissatisfaction is important to facilitate prevention of these problems. This study evaluated the effects of exposure... | ['Adolescent', 'Body Image', 'Defense Mechanisms', 'Female', 'Humans', 'Literacy', 'Mass Media', 'Personal Satisfaction', 'Protective Factors', 'Risk Factors', 'Social Values', 'Thinking', 'Thinness'] | 26,880,285 | [['M01.060.057'], ['F01.752.747.792.110', 'F02.463.593.112'], ['F01.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.429', 'N01.824.196.500'], ['L01.178.590'], ['F01.145.677'], ['E05.318.740.600.800.582', 'N05.715.350.200.675', 'N05.715.360.750.625.700.570', 'N06.850.490.625.625', 'N06.850.520.830.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A biologically based model for recognition of 2-D occluded patterns. | In this work, we present a biologically inspired model for recognition of occluded patterns. The general architecture of the model is based on the two visual information processing pathways of the human visual system, i.e. the ventral and the dorsal pathways. The proposed hierarchically structured model consists of thr... | ['Brain', 'Computer Simulation', 'Humans', 'Models, Biological', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Recognition, Psychology'] | 24,122,414 | [['A08.186.211'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.723.729'], ['F02.463.425.540.706']] | ['Anatomy [A]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neurologic dysfunction and genotoxicity induced by low levels of chlorpyrifos. | Chlorpyrifos (CPF) is an organophosphorus cholinesterase inhibitor widely used as an insecticide. Neuro and genotoxicity of this agent were evaluated following daily subcutaneous injections at 0.1, 1 and 10mg/kg or its vehicle to laboratory rats during one week, at the end of which somatosensory evoked potentials (SEP)... | ['Acetylcholinesterase', 'Acoustic Stimulation', 'Animals', 'Body Temperature', 'Body Weight', 'Butyrylcholinesterase', 'Carboxylesterase', 'Cerebral Cortex', 'Chlorpyrifos', 'Cholinesterase Inhibitors', 'DNA Damage', 'Dose-Response Relationship, Drug', 'Electroencephalography', 'Esterases', 'Evoked Potentials, Somatos... | 25,196,089 | [['D08.811.277.352.100.170.176'], ['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.277.352.100.170.250'], ['D08.811.277.352.100.100'], ['A08.186.2... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Moderate sedation in cardiac electrophysiology laboratory: a retrospective safety analysis. | OBJECTIVE: Cardiac electrophysiology (EP) procedures can be performed under moderate sedation without the direct involvement of an anaesthetist. However, concerns have been raised over the safety of this approach. This study examines the use of a standardised nurse-led physician-directed sedation protocol for EP proced... | ['Aged', 'Cardiac Electrophysiology', 'Cardiac Surgical Procedures', 'Conscious Sedation', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Retrospective Studies', 'Treatment Outcome'] | 28,249,993 | [['M01.060.116.100'], ['H01.158.344.528.500', 'H01.158.782.236.500', 'H02.403.429.163.300'], ['E04.100.376', 'E04.928.220'], ['E03.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['E05.318.372.50... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Lifestyle and other factors predict ankle fractures in perimenopausal women: a population-based prospective cohort study. | The Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study examines the risk factors for fractures and low bone density in middle-aged women. In the present study we investigated lifestyle and other risk factors for ankle fracture. The study population consisted of 11,798 women, aged 47-56 years at baseline. Dur... | ['Ankle Injuries', 'Body Mass Index', 'Cohort Studies', 'Drug Prescriptions', 'Epidemiologic Factors', 'Female', 'Finland', 'Humans', 'Life Style', 'Middle Aged', 'Prospective Studies', 'Risk Factors', 'Smoking'] | 11,792,591 | [['C26.558.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.319.307', 'N02.421.668.778.500'], ['N05.715.350', 'N06.850.490'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.11... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The use of auricular examination for screening hepatic disorders. | Researches on auricular acupuncture (AA) have examined mainly its treatment effects. This study aimed to investigate the accuracy and precision of using auricular examination (AE) as a complementary diagnostic tool for screening hepatic disorders. Twenty patients suffering from liver dysfunction and 25 controls aged 18... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Diagnostic Techniques and Procedures', 'Ear', 'Female', 'Humans', 'Liver Diseases', 'Male', 'Middle Aged', 'Young Adult'] | 20,633,472 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370'], ['A01.456.313', 'A09.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552'], ['M01.060.116.630'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Necrotising fasciitis in both calves caused by Aeromonas caviae following aesthetic liposuction. | Liposuction is the most widely performed cosmetic procedure in the world, and is considered safe and without serious complications. However, necrotising fasciitis has been documented as a rare complication following abdomen and thigh liposuction. We present a case of necrotising fasciitis in a 22-year-old female who un... | ['Aeromonas', 'Anti-Bacterial Agents', 'Combined Modality Therapy', 'Debridement', 'Diagnosis, Differential', 'Fasciitis, Necrotizing', 'Female', 'Gram-Negative Bacterial Infections', 'Humans', 'Leg', 'Lipectomy', 'Magnetic Resonance Imaging', 'Multiple Organ Failure', 'Necrosis', 'Skin Transplantation', 'Young Adult'] | 20,471,929 | [['B03.440.450.019.025'], ['D27.505.954.122.085'], ['E02.186'], ['E04.176'], ['E01.171'], ['C05.321.550'], ['C01.150.252.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['E02.218.530', 'E02.650.500.062.937', 'E04.062.937', 'E04.680.450'], ['E01.370.350.825.500'], ['C23.550.835.525'], ['C23.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses. | BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-?-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a dysfunctional Kv11.1 voltage-... | ['Aged', 'Cohort Studies', 'Denmark', 'ERG1 Potassium Channel', 'Fasting', 'Female', 'Gain of Function Mutation', 'Gastric Inhibitory Polypeptide', 'Glucagon', 'Glucagon-Like Peptide 1', 'Glucose', 'Glucose Tolerance Test', 'Humans', 'Incretins', 'Long QT Syndrome', 'Male', 'Randomized Controlled Trials as Topic', 'Ret... | 29,548,277 | [['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.816.124'], ['D12.776.157.530.400.600.900.249.500', 'D12.776.543.550.450.750.900.249.500', 'D12.776.543.585.400.750.900.249.500'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['G05.365.59... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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