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Chip-based protein-protein interaction studied by atomic force microscopy. | In this article, a technique for accurate direct measurement of protein-to-protein interactions before and after the introduction of a drug candidate is developed using atomic force microscopy (AFM). The method is applied to known immunosuppressant drug candidate Echinacea purpurea derived cynarin. T-cell/CD28 is on-ch... | ['B7-1 Antigen', 'CD28 Antigens', 'Cinnamates', 'Microscopy, Atomic Force', 'Protein Binding', 'Protein Interaction Mapping', 'Proteins'] | 22,511,236 | [['D12.776.467.150.100', 'D12.776.543.095.100', 'D23.050.301.285.100', 'D23.529.168.100'], ['D12.776.543.750.705.222.500', 'D23.050.301.264.894.128', 'D23.101.100.894.128'], ['D02.241.223.200'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['G02.111.679', 'G03.808'], ['E05.601.690'], ['D12.776']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Baby massage classes and the work of the International Association of Infant Massage. | This article describes the role of the International Association of Infant Massage (IAIM) in promoting the importance of touch for the developing relationship between the parents and infants. Infants are unique personalities and it is important that the parent learns how to respond appropriately to the infant's needs. ... | ['Child Health Services', 'England', 'Female', 'Humans', 'Infant', 'Infant Care', 'International Agencies', 'Male', 'Massage', 'Parent-Child Relations', 'Patient Education as Topic'] | 11,855,526 | [['N02.421.143.130'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N02.421.088.120'], ['N03.540.514'], ['E02.190.599.750.750', 'E02.779.867.880.750', 'E02.831.535.867.880.750'], ['F01.829.263.370.290'], ['I02.233.332.500', 'N02.421.726.407.680']] | ['Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
On chromosomal DNA modifications by chemical and physical treatment of C-bands. | Experiments were performed on fixed metaphase chromosomes using standard techniques for revealing paracentromeric heterochromatin (C bands) followed by staining with acridine orange with the aim of studying C-banding mechanism. Data obtained suggest that the specific resistance to the chemical-physical treatments of th... | ['Acridine Orange', 'Barium', 'Barium Compounds', 'Centrifugation', 'Chromosome Banding', 'Heterochromatin', 'Humans'] | 3,442,554 | [['D03.633.300.046.250.150'], ['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['D01.103'], ['E05.181'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
mBeRFP, an improved large stokes shift red fluorescent protein. | Herein, we describe the generation of a monomeric large Stokes shift (LSS) red fluorescent protein, mBeRFP, with excitation and emission peaks at 446 and 615 nm, respectively. Compared with two previously reported LSS-RFPs (mKeima and LSS-mKate2), mBeRFP is approximately three times brighter. In addition, mBeRFP is cha... | ['Amino Acid Substitution', 'Apoptosis', 'Fluorescence Resonance Energy Transfer', 'HeLa Cells', 'Humans', 'Hydrogen-Ion Concentration', 'Luminescent Proteins', 'Microscopy, Confocal', 'Mutagenesis, Site-Directed', 'Recombinant Proteins'] | 23,840,310 | [['E05.393.420.601.035', 'G05.558.109'], ['G04.146.954.035'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D12.776.532'], ['E01.370.350.515.395', 'E05.595.395'], ['E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of chlamydia genus-specific and species-specific IgG antibody testing in predicting tubal disease in subfertile women. | BACKGROUND: We evaluated whether measuring chlamydia genus- and species-specific immunoglobulin (Ig) G antibodies might improve the predictive value of C. trachomatis antibody testing (CAT) in screening for distal tubal pathology (DTP).METHODS: Serum of 313 subfertile women was tested for the presence of species-specif... | ['Adult', 'Antibodies, Bacterial', 'Chlamydia', 'Chlamydia trachomatis', 'Fallopian Tube Diseases', 'Female', 'Humans', 'Immunoglobulin G', 'Infertility, Female', 'Lipopolysaccharides', 'Predictive Value of Tests', 'Species Specificity'] | 15,105,400 | [['M01.060.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['B03.440.190.190.190'], ['B03.440.190.190.190.750'], ['C13.351.500.056.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel, self-assembled artificial cartilage-hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints. | Purpose: We previously created a self-assembled cartilage-like complex in vitro from only three cartilage components, hyaluronic acid (HA), aggrecan (AG) and type II collagen, without other materials such as cross-linking agents. Based on this self-organized AG/HA/collagen complex, we have created three novel types of ... | ['Aged', 'Animals', 'Bone Regeneration', 'Cartilage, Articular', 'Cells, Cultured', 'Chondrocytes', 'Collagen Type II', 'Durapatite', 'Elasticity', 'Humans', 'Knee Joint', 'Male', 'Osteoarthritis', 'Rats, Sprague-Dawley', 'Tissue Engineering', 'Tissue Scaffolds', 'Viscosity'] | 30,863,061 | [['M01.060.116.100'], ['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.251'], ['A11.329.171'], ['D05.750.078.280.300.200', 'D12.776.860.300.250.300.200'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. | PURPOSE: Elevated cyclin D1 in human pancreatic cancer correlates with poor prognosis. Because pancreatic cancer is invariably resistant to chemotherapy, the goal of this study was to examine whether the drug resistance of pancreatic cancer cells is in part attributed to cyclin D1 overexpression.EXPERIMENTAL DESIGN: St... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Cisplatin', 'Culture Media', 'Cyclin D1', 'Deoxycytidine', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Drug Resistance, Neoplasm', 'Electrophoretic Mobility Shift Assay', 'Female', 'Fl... | 16,115,953 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D27.720.470.305', 'E07.206'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Attitudes and sexual function in Thai pregnant women. | OBJECTIVE: To evaluate the attitudes towards sexuality and sexual function in Thai pregnant women.MATERIAL AND METHOD: A cross-sectional study was conducted among 347 healthy pregnant women, aged 14-42 years, who attended the antenatal clinic, Ratchaphiphat Hospital. The Female Sexual Function Index (FSFI) questionnair... | ['Adult', 'Attitude', 'Cross-Sectional Studies', 'Female', 'Humans', 'Pregnancy', 'Prospective Studies', 'Sexuality', 'Thailand', 'Young Adult'] | 20,420,099 | [['M01.060.116'], ['F01.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['F01.145.802.975', 'G08.686.867'], ['Z01.252.145... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. | Wild-type p53 is necessary for the growth arrest of human diploid fibroblasts (HDF) (and many other cell types) at the end of their proliferative lifespan. Although p53 may actively mediate senescence, possibly in response to telomere erosion, it is however equally possible that it is merely a permissive factor require... | ['Cell Line', 'Cellular Senescence', 'DNA', 'DNA Damage', 'Fibroblasts', 'Genes, Reporter', 'Humans', 'Transcriptional Activation', 'Transfection', 'Tumor Suppressor Protein p53'] | 8,950,976 | [['A11.251.210'], ['G04.043'], ['D13.444.308'], ['G05.200'], ['A11.329.228'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.308.800'], ['E05.393.350.810', 'G05.728.860'], ['D12.776.157.687.650', 'D12.776.260.820', 'D12.776.624.776.775', 'D12.776.660.720.650', 'D12.776.744.845']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. | PURPOSE: ADHD is reported as a frequent comorbidity in pediatric epilepsy. We aimed to clarify the prevalence of ADHD, its neurological correlates and the role of ADHD in health-related quality of life (HRQOL) in children with severe epilepsy.METHOD: Data from the ADHD Rating Scale-IV (ADHD-RS-IV) from 203 children (me... | ['Activities of Daily Living', 'Adolescent', 'Adult', 'Age Factors', 'Anticonvulsants', 'Attention Deficit Disorder with Hyperactivity', 'British Columbia', 'Child', 'Child, Preschool', 'Cognition Disorders', 'Comorbidity', 'Epilepsy', 'Female', 'Health Status', 'Humans', 'Male', 'Neuropsychological Tests', 'Prevalence... | 17,381,442 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D27.505.954.427.080'], ['F03.625.094.150'], ['Z01.107.567.176.160'], ['M01.060.406'], ['M01.060.406.448'], ['F03.615.250'], ['N05.715.350.225', 'N06.850.490.687'], ['C10... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries. | Knowledge of the intrinsic material properties of healthy and diseased arterial tissue components is of great importance in diagnostics. This study describes an in vitro comparison of 13 porcine carotid arteries using inflation testing combined with functional ultrasound and bi-axial tensile testing. The measured tissu... | ['Animals', 'Carotid Arteries', 'Computer Simulation', 'Image Interpretation, Computer-Assisted', 'In Vitro Techniques', 'Models, Biological', 'Pattern Recognition, Automated', 'Pressure', 'Reference Values', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Stress, Mechanical', 'Swine', 'Tensile Strength',... | 26,598,396 | [['B01.050'], ['A07.015.114.186'], ['L01.224.160'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E05.481'], ['E05.599.395'], ['L01.399.750'], ['G01.374.715'], ['E05.978.810'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872',... | ['Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Diagnostic utility of the molecular assay GenoType MTBC (HAIN Lifesciences, Germany) for identification of tuberculous mycobacteria]. | INTRODUCTION: The GenoType system (HAIN Lifescience, Germany) offers new perspectives of detecting the tuberculous and non-tuberculous mycobacteria at the molecular level. The system compromises five independent tests that could be performed either on direct specimens or isolated strains, to identify the strains and te... | ['Bacterial Proteins', 'Chromatography, High Pressure Liquid', 'Genotype', 'Humans', 'Mycobacterium tuberculosis', 'Mycolic Acids', 'Nucleic Acid Hybridization', 'Peptide Fragments', 'Species Specificity', 'Tuberculosis'] | 20,013,701 | [['D12.776.097'], ['E05.196.181.400.300'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['D02.241.511.621', 'D10.251.572'], ['E05.393.661', 'G02.111.611'], ['D12.644.541'], ['G16.824'], ['C01.150.252.410.040.552.846']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Determining factors in patient satisfaction with erectile dysfunction treatment]. | INTRODUCTION: Erectile dysfunction (ED) is associated with depression, anxiety and loss of self-esteem, deteriorating patient's quality of life. The present study aimed, to identify and evaluate key factors influencing patient's satisfaction with ED treatment. To analyze which of them have a greater impact on patient's... | ['Cross-Sectional Studies', 'Erectile Dysfunction', 'Humans', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Surveys and Questionnaires'] | 19,143,291 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['E05.318.308.980', 'N05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Functional properties of free and encapsulated Lactobacillus reuteri DPC16 during and after passage through a simulated gastrointestinal tract. | Lactobacillus reuteri DPC16 is a probiotic bacterium that has strong antimicrobial activities on pathogens, mainly due to its ability to produce reuterin, an antimicrobial compound. The objective of this study was to examine the ability of an encapsulation technique to protect the functional properties of cells of L. r... | ['Bacterial Adhesion', 'Caco-2 Cells', 'Epithelial Cells', 'Escherichia coli', 'Escherichia coli Infections', 'Gastrointestinal Tract', 'Glyceraldehyde', 'HT29 Cells', 'Humans', 'Lactobacillus reuteri', 'Listeria monocytogenes', 'Models, Biological', 'Probiotics', 'Propane', 'Salmonella', 'Staphylococcus aureus'] | 22,806,780 | [['G06.099.050'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['A11.436'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['A03.556'], ['D02.047.587', 'D09.947.875.894.449'], ['A11.251.210.190.475', 'A11.251.860.180.475', 'A11.436.365'], ['B01.050.150.900.649.313... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effects of health insurance and a usual source of care on a child's receipt of health care. | INTRODUCTION: Although recent health care reforms will expand insurance coverage for U.S. children, disparities regarding access to pediatric care persist, even among the insured. We investigated the separate and combined effects of having health insurance and a usual source of care (USC) on children's receipt of healt... | ['Adolescent', 'Child', 'Child Health Services', 'Child, Preschool', 'Cross-Sectional Studies', 'Female', 'Health Care Reform', 'Health Services Accessibility', 'Humans', 'Infant', 'Infant, Newborn', 'Insurance Coverage', 'Insurance, Health', 'Male', 'Parents', 'Primary Health Care', 'Socioeconomic Factors', 'United St... | 22,920,780 | [['M01.060.057'], ['M01.060.406'], ['N02.421.143.130'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['N04.590.374.350', 'N05.300... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Kinematics and kinetics of normal and planovalgus feet during walking. | Planovalgus deformity is prevalent in cerebral palsy patients, but very few studies have quantitatively reported differences between planovalgus and normal foot function. Intersegmental foot kinetics have not been reported in this population. In this study, a three segment (hindfoot, forefoot, hallux) kinematic and kin... | ['Adolescent', 'Ankle Joint', 'Biomechanical Phenomena', 'Case-Control Studies', 'Child', 'Female', 'Flatfoot', 'Foot Deformities', 'Foot Joints', 'Forefoot, Human', 'Gait', 'Humans', 'Kinetics', 'Male', 'Pronation', 'Range of Motion, Articular', 'Supination'] | 24,001,868 | [['M01.060.057'], ['A02.835.583.378.062'], ['G01.154.090', 'G01.374.089'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['C05.330.488.655.250', 'C05.330.495.681.250', 'C05.660.585.512.380.813.250', 'C16.131.621.585.512.500.681.250'], ['C05.330'], ['A02.835.583.378'], [... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Study Design, Protocol and Profile of the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) Pregnancy Cohort: a Prospective Cohort Study in Predominantly Low-Income Hispanic Women in Urban Los Angeles. | BACKGROUND: The burden of childhood and adult obesity disproportionally affects Hispanic and African-American populations in the US, and these groups as well as populations with lower income and education levels are disproportionately affected by environmental pollution. Pregnancy is a critical developmental period whe... | ['Adult', 'Environmental Exposure', 'Female', 'Gestational Weight Gain', 'Hispanic Americans', 'Humans', 'Infant, Newborn', 'Los Angeles', 'Maternal Exposure', 'Pediatric Obesity', 'Poverty', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Prospective Studies', 'Research Design', 'Risk Factors', 'Social Determinants... | 31,146,718 | [['M01.060.116'], ['N06.850.460.350'], ['C23.888.144.243.926.500', 'G07.345.249.314.120.200.926.500', 'G08.686.330'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['Z01.107.567.875.580.200.450', 'Z01.107.567.875.760.200.450', 'Z01.433.565'], ['N06.850.460.350.145'], ['C18.6... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Invertase Suc2-mediated inulin catabolism is regulated at the transcript level in Saccharomyces cerevisiae. | BACKGROUND: Invertase Suc2 was recently identified as a key hydrolase for inulin catabolism in Saccharomyces cerevisiae, whereas the Suc2 activity degrading inulin varies greatly in different S. cerevisiae strains. The molecular mechanism causing such variation remained obscure. The aim of this study is to investigate ... | ['Inulin', 'Saccharomyces cerevisiae', 'beta-Fructofuranosidase'] | 25,890,240 | [['D05.750.078.562.855.750', 'D09.301.915.750', 'D09.698.350.500', 'D09.698.365.855.750'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D08.811.277.450.114']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In touch but not up-to-date: ambulatory visits and vaccination status in a cohort of young Swiss children. | OBJECTIVE: Incomplete and delayed vaccination is a barrier to individual and population protection from vaccine-preventable diseases. We aimed to assess visit frequency and pattern in relation to vaccination status in a Swiss cohort of 2-year-old children in order to review opportunities for completion of scheduled imm... | ['Ambulatory Care', 'Child, Preschool', 'Cohort Studies', 'Female', 'Humans', 'Immunization Schedule', 'Infant', 'Male', 'Medication Adherence', 'Office Visits', 'Retrospective Studies', 'Switzerland', 'Vaccination'] | 24,075,922 | [['E02.760.106', 'N02.421.585.106'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400.470', 'E05.478.550.545'], ['M01.060.703'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.500', 'N05.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Revealing Functional Crosstalk between Distinct Bioprocesses through Reciprocal Functional Tests of Genetically Interacting Genes. | To systematically explore the genes mediating functional crosstalk between metazoan biological processes, we apply comparative genetic interaction (GI) mapping in Saccharomyces cerevisiae and Caenorhabditis elegans to generate an inter-bioprocess network consisting of 178 C. elegans GIs. The GI network spans six annota... | ['Animals', 'Biological Transport', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Endosomes', 'Humans'] | 31,775,035 | [['B01.050'], ['G03.143'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['A11.284.430.214.190.875.190.880.337'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Orthodontic and nonorthodontic root resorption: their impact on clinical dental practice. | Occasionally, general dentists are challenged with providing restorative treatment for a postorthodontic patient who has had moderate to severe root resorption. When this happens, a number of questions about the cause of such resorption and the appropriate treatment arise in the dentist's mind. This article will descri... | ['Adolescent', 'Adult', 'Anodontia', 'Bicuspid', 'Cuspid', 'Dental Veneers', 'Denture, Partial, Fixed', 'Denture, Partial, Temporary', 'Esthetics, Dental', 'Female', 'Follow-Up Studies', 'Humans', 'Incisor', 'Open Bite', 'Orthodontic Wires', 'Orthodontics, Corrective', 'Patient Care Planning', 'Root Resorption', 'Tooth... | 18,676,798 | [['M01.060.057'], ['M01.060.116'], ['C07.650.800.100', 'C07.793.700.100', 'C16.131.850.800.100'], ['A14.549.167.860.150'], ['A14.549.167.860.200'], ['E06.780.346.750', 'E07.695.190.196'], ['E06.780.346.760.943.271', 'E07.695.190.200.220.220'], ['E06.780.346.760.943.484', 'E07.695.190.200.220.235'], ['E06.420'], ['E05.3... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reasons for Reperfusion Failures in Stent-Retriever-Based Thrombectomy: Registry Analysis and Proposal of a Classification System. | BACKGROUND AND PURPOSE: In 5%-10% of patients with acute ischemic stroke with an intention to treat with mechanical thrombectomy, no reperfusion can be achieved (Thrombolysis in Cerebral Infarction score = 0/1). Purpose of this analysis was a systematic assessment of underlying reasons for reperfusion failures.MATERIAL... | ['Aged', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Registries', 'Reperfusion', 'Stents', 'Stroke', 'Thrombectomy', 'Treatment Failure'] | 30,166,434 | [['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['E04.100.700', 'E05.680.730'], ['E07.695.750'], ['C10.228.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Seasonal distribution of macrozoobenthos and its relations to environmental factors in Oujiang River estuary sea area]. | To evaluate the seasonal distribution of macrozoobenthos and its relations to environmental factors in Oujiang River estuary and adjacent waters, two cruise surveys were conducted in May 2006 (spring) and January 2007 (winter). A total of 65 species were collected, among which, polychaeta and mollusk were the dominant ... | ['Animals', 'China', 'Ecosystem', 'Environmental Monitoring', 'Fresh Water', 'Invertebrates', 'Mollusca', 'Oceans and Seas', 'Phytoplankton', 'Polychaeta', 'Rivers', 'Seasons', 'Seawater', 'Temperature'] | 19,947,218 | [['B01.050'], ['Z01.252.474.164'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.280', 'N06.230.232'], ['B01.050.500'], ['B01.050.500.644'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ['B05.080.500.600'], ['B01.050.500.091.700'], ['G01.311.750', 'G16.500.275.2... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Molecular fingerprinting of isoniazid-resistant Mycobacterium tuberculosis isolates from chest diseases hospital in Kuwait. | Touchdown double-repetitive-element-PCR (DRE-PCR) was carried out for typing 38 consecutive isoniazid-resistant Mycobacterium tuberculosis strains isolated at Chest Diseases Hospital, Kuwait, during 1998-2000. The polymorphism at codon 463 in the katG gene was also determined and correlated with genotypic relationships... | ['Antitubercular Agents', 'Bacterial Proteins', 'Bacterial Typing Techniques', 'DNA Fingerprinting', 'DNA Transposable Elements', 'Drug Resistance, Bacterial', 'Female', 'Hospitals, Special', 'Humans', 'Isoniazid', 'Kuwait', 'Lung Diseases', 'Male', 'Microbial Sensitivity Tests', 'Mycobacterium tuberculosis', 'Peroxida... | 12,516,773 | [['D27.505.954.122.085.255'], ['D12.776.097'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G06.099.225', 'G06.225.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Intensive care for very low birthweight infants in South Africa: a survey of physician attitudes, parent counseling and resuscitation practices. | Improving outcomes have promoted utilization of intensive care for premature infants in developing countries with available fiscal and technological resources. Physician counseling and decision-making have not been characterized where economic restrictions, governmental guidelines, and physician cultural attitudes may ... | ['Adult', 'Attitude of Health Personnel', 'Counseling', 'Critical Care', 'Cross-Sectional Studies', 'Developing Countries', 'Female', 'Health Care Surveys', 'Humans', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Infant, Very Low Birth Weight', 'Male', 'Medically Underserved Area', 'Outcome Assessment, Health Care... | 15,601,654 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['E02.760.190', 'N02.421.585.190'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.615.500.300'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells. | We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of gr... | ['Acquired Immunodeficiency Syndrome', 'Aminoglycosides', 'Anti-Bacterial Agents', 'Antibiotics, Antineoplastic', 'Apoptosis', 'Cell Division', 'DNA, Neoplasm', 'Drug Screening Assays, Antitumor', 'Endothelium', 'Humans', 'Male', 'Muscle, Smooth, Vascular', 'Sarcoma, Kaposi', 'Skin Neoplasms', 'T-Lymphocytes', 'Tumor C... | 8,044,770 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['D09.408.051'], ['D27.505.954.122.085'], ['D27.505.954.248.106'], ['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.7... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study. | BACKGROUND: Parabens are a group of esters of para-hydroxybenzoic acid utilized as antimicrobial preservatives in many personal care products. Epidemiological studies regarding the adverse effects of parabens on fetuses are limited. The aim of this study was to determine the association between placental paraben exposu... | ['Belgium', 'Birth Weight', 'Cohort Studies', 'Environmental Monitoring', 'Environmental Pollutants', 'Female', 'Head', 'Humans', 'Infant, Newborn', 'Maternal Exposure', 'Parabens', 'Placenta', 'Pregnancy'] | 32,664,952 | [['Z01.542.115'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['A01.456'], ['B01.050.15... | ['Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. | The purpose of the present study was to compare the characteristics of three different exercise tests in evaluating the effects of oxitropium bromide on exercise performance. Thirty-eight males with stable chronic obstructive pulmonary disease (COPD) (FEV(1) = 40.8 +/- 16.5% predicted; mean +/- SD) completed randomized... | ['Administration, Inhalation', 'Aged', 'Bronchodilator Agents', 'Cross-Over Studies', 'Double-Blind Method', 'Exercise Test', 'Humans', 'Lung Diseases, Obstructive', 'Lung Volume Measurements', 'Male', 'Middle Aged', 'Parasympatholytics', 'Physical Endurance', 'Scopolamine Derivatives'] | 10,852,763 | [['E02.319.267.050'], ['M01.060.116.100'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Optimization of sampling time for cyclosporine monitoring in transplant patients. | Cyclosporine (CsA) dosing is based on CsA plasma or blood concentrations measured 12 to 24 hours after drug administration (trough levels). This study evaluated the relationship between the timing of CsA concentrations and subsequent pharmacokinetic parameters to predict an optimal sampling period. Plasma samples were ... | ['Adolescent', 'Adult', 'Child', 'Chromatography, High Pressure Liquid', 'Cyclosporine', 'Drug Monitoring', 'Fluorescence Polarization Immunoassay', 'Heart Transplantation', 'Humans', 'Middle Aged', 'Time Factors'] | 1,474,170 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E05.196.181.400.300'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['E01.370.520.200'], ['E01.370.225.500.607.512.240.655.350', 'E01.370.225.750.551.512.240.655.350', 'E05.196.712.516.600.390.350', 'E05.200.500.607.512.240.655.350', 'E05.200.750.551.512.240.655.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Combined effects of FLT3 and NF-êB selective inhibitors on acute myeloid leukemia in vivo. | FMS-like tyrosine kinase 3 (FLT3) is an independent poor prognostic marker of acute myeloid leukemia (AML), and strategies that specifically target FLT3 are therefore of substantial interest. However, previous studies with FLT3 inhibitors as single agents in patients with AML showed few clinical responses. In the prese... | ['Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Apoptosis', 'Benzamides', 'Cell Line, Tumor', 'Cyclin D1', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'NF-kappa B', 'Nuclear Receptor Co-Repressor 2', 'Proto-Oncogene Proteins c-bcl-2', 'Sesquiterpenes', 'Thio... | 21,928,377 | [['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G04.146.954.035'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['B01... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spinal cord compression and blood flow. I. The effect of raised cerebrospinal fluid pressure on spinal cord blood flow. | The effect of cerebrospinal fluid pressure (CSFP) on spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, was studied in dogs. CSFP was altered by the infusion of mock CSF into the lumbar subarachnoid space. Occluding snares at T-13 limited the effect of raised pressure on the brain. As the perf... | ['Animals', 'Carbon Dioxide', 'Cerebrospinal Fluid', 'Dogs', 'Intracranial Pressure', 'Pressure', 'Regional Blood Flow', 'Spinal Cord', 'Spinal Cord Compression', 'Vascular Resistance'] | 568,734 | [['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['A12.207.270.210'], ['B01.050.150.900.649.313.750.250.216.200'], ['G11.561.170.505'], ['G01.374.715'], ['G09.330.100.780'], ['A08.186.854'], ['C10.228.854.761', 'C26.819.678'], ['G09.330.380.921']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Modifications in and prognostic value of the EEG in anoxic encephalopathy: 75 cases]. | The use of new cardiopulmonary resuscitation techniques has considerably increased the possibility of survival after cardiopulmonary arrest. It is of considerable interest to evaluate the extent of any anoxic brain damage. The EEG has proven very informative in the assessment of cerebral function in patients with anoxi... | ['Adult', 'Aged', 'Aged, 80 and over', 'Brain Death', 'Electroencephalography', 'Female', 'Glasgow Coma Scale', 'Humans', 'Hypoxia, Brain', 'Male', 'Middle Aged', 'Prognosis'] | 1,925,477 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.151', 'C10.597.606.358.800.200.100', 'C23.550.260.159'], ['E01.370.376.300', 'E01.370.405.245'], ['E05.318.308.940.968.875.250', 'E05.944.500', 'N04.452.859.564.800.250', 'N05.715.360.300.715.500.800.325'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Horner's law. The first step in the history of the understanding of X-linked disorders. | Earlier reports on colour blindness are descriptions which almost always mention the familial occurrence. Horner's publications (1876), however, gave the first scientific analysis of the hereditary transmission of Daltonism. Since this genealogic study was published only in a local bulletin of the City of Zurich it see... | ['Color Vision Defects', 'Genetic Linkage', 'Genetics', 'History, 19th Century', 'Humans', 'Ophthalmology', 'Pedigree', 'Switzerland', 'X Chromosome'] | 1,495,767 | [['C10.597.751.941.256', 'C11.270.151.500', 'C11.966.256', 'C23.888.592.763.941.256'], ['G05.348'], ['H01.158.273.343'], ['K01.400.504.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.468'], ['E05.393.673'], ['Z01.542.883'], ['A11.284.187.865.982', 'G05.360.162.865.982']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions. | Training working memory (WM) improves performance on untrained cognitive tasks and alters functional activity. However, WM training's effects on gray matter morphology and a wide range of cognitive tasks are still unknown. We investigated this issue using voxel-based morphometry (VBM), various psychological measures, s... | ['Female', 'Frontal Lobe', 'Humans', 'Male', 'Memory, Short-Term', 'Neuropsychological Tests', 'Parietal Lobe', 'Placebos', 'Regression Analysis', 'Task Performance and Analysis', 'Young Adult'] | 21,886,781 | [['A08.186.211.200.885.287.500.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['F04.711.513'], ['A08.186.211.200.885.287.500.670'], ['D26.660', 'E02.785'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['M01.06... | ['Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Shotgun proteomics study of early biofilm formation process of Acidithiobacillus ferrooxidans ATCC 23270 on pyrite. | Acidithiobacillus ferrooxidans is a chemolithoautotrophic, mesophilic Gram-negative bacterium able to oxidize ferrous iron, sulfur, and metal sulfides. It forms monolayer biofilms where extracellular polymeric substances are essential for cell attachment and metal sulfide leaching. High-throughput proteomics has been a... | ['Acidithiobacillus', 'Bacterial Proteins', 'Biofilms', 'Iron', 'Plankton', 'Proteome', 'Proteomics', 'Sulfides'] | 23,319,327 | [['B03.440.400.425.103', 'B03.660.250.015'], ['D12.776.097'], ['A20.593', 'G06.120'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['B05.080.500'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression. | We previously reported that fenretinide (4HPR) is effective against a human ovarian carcinoma xenografted in nude mice. The effects of 4HPR on ovarian tumors have been further studied in in vitro ovarian carcinoma cell lines A2780, IGROV-I, SW626 and OVCA432. A2780 was the most sensitive line: 50% growth inhibition was... | ['Antineoplastic Agents', 'Cell Cycle', 'Cell Division', 'Cisplatin', 'Female', 'Fenretinide', 'Humans', 'Ovarian Neoplasms', 'RNA, Messenger', 'Receptors, Retinoic Acid', 'Tumor Cells, Cultured'] | 8,621,233 | [['D27.505.954.248'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.326.271.665.202.495.270', 'D02.455.426.392.368.367.379.249.700.270', 'D02.455.849.131.495.270', 'D23.767.261.700.270'], ['B01.050.150.900.649.313.988.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ef?cacy and metabolic influence of paliperidone ER, aripiprazole and ziprasidone to patients with first-episode schizophrenia through 52 weeks follow-up in China. | BACKGROUND: There are no direct comparisons of paliperidone extended-release (ER), aripiprazole and ziprasidone in efficacy and metabolic influence in patients with first-episode schizophrenia.OBJECTIVE: The present study examined the efficacy and metabolic influence of paliperidone ER, aripiprazole and ziprasidone in ... | ['Adult', 'Antipsychotic Agents', 'Aripiprazole', 'Body Mass Index', 'China', 'Delayed-Action Preparations', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperglycemia', 'Hyperlipidemias', 'Isoxazoles', 'Male', 'Metabolic Diseases', 'Paliperidone Palmitate', 'Pipera... | 24,446,539 | [['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.383.606.170', 'D03.633.100.810.835.122'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.252.474.164'], ['D26.255.210', 'E02.319.300.253'], ['L01.453.24... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The influence of socio-economic status and multimorbidity patterns on healthcare costs: a six-year follow-up under a universal healthcare system. | INTRODUCTION: Multimorbidity has been linked to elevated healthcare utilization and previous studies have found that socioeconomic status is an important factor associated with multimorbidity. Nonetheless, little is known regarding the impact of multimorbidity and socioeconomic status on healthcare costs and whether in... | ['Adult', 'Aged', 'Comorbidity', 'Databases, Factual', 'Female', 'Follow-Up Studies', 'Health Care Costs', 'Humans', 'Male', 'Middle Aged', 'National Health Programs', 'Social Class', 'Taiwan', 'Young Adult'] | 23,962,201 | [['M01.060.116'], ['M01.060.116.100'], ['N05.715.350.225', 'N06.850.490.687'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116... | ['Named Groups [M]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid beta-peptide aggregation and neurotoxicity. | The aggregation of amyloid beta-peptide (Abeta) in plaques in brain tissue is highly associated with Alzheimer's disease (AD). Aberrant homeostasis of cerebral metals such as Zn(2+) and Cu(2+) may facilitate the formation of the pathogenetic amyloid plaques. Further, the accumulation of redox-active Cu(2+) in these pla... | ['Amyloid beta-Peptides', 'Blood-Brain Barrier', 'Chelating Agents', 'Circular Dichroism', 'Copper', 'Heterocyclic Compounds', 'Humans', 'Microscopy, Atomic Force', 'Nervous System', 'Reactive Oxygen Species', 'Solubility', 'Spectrometry, Fluorescence', 'Spectrometry, Mass, Electrospray Ionization', 'Zinc'] | 19,496,588 | [['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['A07.035', 'A08.186.211.035'], ['D27.505.519.914.500', 'D27.720.832.500'], ['E05.196.867.151'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.666.400', 'E05.595.6... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif. | Rds3p, a component of the U2 snRNP subcomplex SF3b, is essential for pre-mRNA splicing and is extremely well conserved in all eukaryotic species. We report here the solution structure of Rds3p, which reveals an unusual knotted fold unrelated to previously known knotted proteins. Rds3p has a triangular shape with a GATA... | ['Carrier Proteins', 'Cysteine', 'Protein Conformation', 'Ribonucleoprotein, U2 Small Nuclear', 'Saccharomyces cerevisiae Proteins', 'Solutions', 'Zinc Fingers'] | 18,621,724 | [['D12.776.157'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G02.111.570.820.709'], ['D12.776.157.725.500.875.605', 'D12.776.157.725.829.344', 'D12.776.664.962.500.875.605', 'D12.776.664.962.829.344'], ['D12.776.354.750'], ['D26.776'], ['G02.111.570.820.709.275.500.985']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. | We have previously reported novel serine proteases isolated from cDNA libraries of the human and mouse central nervous system (CNS) by PCR using degenerate oligodeoxyribonucleotide primers designed on the basis of the serine protease motifs, AAHC and DSGGP. Here we report a newly isolated serine protease from the mouse... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'COS Cells', 'Chlorocebus aethiops', 'Cloning, Molecular', 'Humans', 'Isoenzymes', 'Membrane Proteins', 'Mice', 'Mitochondrial Proteins', 'Molecular Sequence Data', 'Recombinant Fusion Proteins', 'Sequence Alignment', 'Serine Endopeptidases', 'Tissue Distribution'] | 15,465,023 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.393.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The spatially resolved characterisation of Egyptian blue, Han blue and Han purple by photo-induced luminescence digital imaging. | The photo-induced luminescence properties of Egyptian blue, Han blue and Han purple were investigated by means of near-infrared digital imaging. These pigments emit infrared radiation when excited in the visible range. The emission can be recorded by means of a modified commercial digital camera equipped with suitable ... | ['Color', 'Coloring Agents', 'Light', 'Luminescence', 'Luminescent Measurements', 'Photochemistry'] | 19,234,690 | [['G01.590.540.199'], ['D27.720.233'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['E05.196.712.516'], ['H01.181.529.711']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Nursing research: possibilities of Buber's philosophy]. | The nursing researches have collaborated to build the profession knowledge. The tendency in qualitative methodologies is evident, and among them we highlight the phenomenology approach. This paper will present the possibilities of Martin Buber's philosophy in research. In the field work, it can help the interview techn... | ['Nursing Research', 'Philosophy, Nursing'] | 20,098,887 | [['H01.770.644.145.390', 'H02.478.395', 'N04.590.233.508.613'], ['K01.752.712']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Humanities [K]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication. | Scrapie infectivity is reduced 5-6 logs following filtration through 100,000 MW cut-off filter plus overnight treatment with 6 M urea. These steps, applied to purified human Growth Hormone (hGH), increase the margin of safety of hGH. | ['Animals', 'Creutzfeldt-Jakob Syndrome', 'Cricetinae', 'Female', 'Filtration', 'Growth Hormone', 'Scrapie', 'Sodium Hydroxide', 'Urea'] | 3,277,594 | [['B01.050'], ['C01.207.800.230', 'C10.228.140.380.165', 'C10.228.228.800.230', 'F03.615.400.300'], ['B01.050.150.900.649.313.992.635.075.250'], ['E05.196.454', 'G01.280', 'G02.263'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['C01.207.800.717', 'C10.228.228.800.717', 'C10.574.843.850', 'C22.836.799'], ['... | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An assessment of the effects of casemix funding on hospital utilisation: a Northern Territory perspective. | This article is concerned with the methodological issues of assessing the effects of casemix funding on hospital utilisation. Time-series analysis and intervention analysis are proposed to ascertain the effects. It was found there had been a decline in average length of stay and number of bed-days, an increase in weigh... | ['Diagnosis-Related Groups', 'Economics, Hospital', 'Hospitals', 'Northern Territory', 'Outcome Assessment, Health Care', 'Quality of Health Care'] | 10,947,597 | [['N03.219.521.710.305.200.080'], ['N03.219.262'], ['N02.278.421'], ['Z01.639.100.875', 'Z01.678.100.373.875'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['N04.761', 'N05.715']] | ['Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Visual feedback influences antennal positioning in flying hawk moths. | Insect antennae serve a variety of sensory functions including tactile sensing, olfaction and flight control. For all of these functions, the precise positioning of the antenna is essential to ensure the proper acquisition of sensory feedback. Although antennal movements in diverse insects may be elicited or influenced... | ['Animals', 'Arthropod Antennae', 'Cues', 'Electromyography', 'Feedback, Sensory', 'Flight, Animal', 'Male', 'Moths', 'Muscle, Skeletal', 'Photic Stimulation', 'Visual Perception'] | 24,265,427 | [['B01.050'], ['A13.093'], ['F02.463.425.234'], ['E01.370.405.255', 'E01.370.530.255'], ['F04.754.137.301.500', 'F04.754.308.500.500', 'F04.754.339', 'G07.410.732.500'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['B01.050.500.131.617.720.500.500.937.650'], ['A02.633.567', 'A10.690.552.500'], ['E05.723.729'], ['F0... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antigenic drift of non-encapsulated Haemophilus influenzae major outer membrane protein P2 in patients with chronic bronchitis is caused by point mutations. | The sequence of the gene encoding major outer membrane protein (MOMP) P2 of antigenic variants of non-encapsulated Haemophilus influenzae isolated from persistently infected chronic bronchitis patients was analysed. Antigenic drift was shown to result from single base changes in the P2 gene, all generating amino acid c... | ['Amino Acid Sequence', 'Animals', 'Antigenic Variation', 'Antigens, Bacterial', 'Bacterial Capsules', 'Bacterial Outer Membrane Proteins', 'Base Sequence', 'Bronchitis', 'Chronic Disease', 'Diffusion Chambers, Culture', 'Disease Models, Animal', 'Gene Frequency', 'Genes, Bacterial', 'Haemophilus influenzae', 'Humans',... | 8,022,287 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G05.365.073', 'G12.500.249'], ['D23.050.161'], ['A20.186'], ['D12.776.097.120', 'D12.776.543.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['C23.550.291.500'], ['E07.241'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans. | Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high concentrations of superoxide (O(2)(-)). This behavior limits the amount of H(2)O(2) produced at high [O(2)(-)]; its desirability can be explained by the multiple roles of H(2)O(2) in mammalian cells, particularly its role in signaling. To... | ['Candida albicans', 'Catalytic Domain', 'Crystallography, X-Ray', 'Electron Spin Resonance Spectroscopy', 'Kinetics', 'Models, Molecular', 'Oxidation-Reduction', 'Protein Multimerization', 'Saccharomyces cerevisiae', 'Superoxide Dismutase'] | 22,077,216 | [['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.196.309.742.225'], ['E05.196.867.519.274'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['G02.700', 'G03.295.531'], ['G02.111.694'], ['B01.300.107.795.785.800', 'B01.300.930... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A kinetic study on the enzymatic hydrolysis of fluorescein diacetate and fluorescein-di-beta-D-galactopyranoside. | The kinetics of the hydrolysis of fluoresceindiacetate and fluorescein-di-beta-D-galactopyranoside were investigated by thin-layer chromatography. The time course of the concentrations of substrate, monosubstituted intermediate, and product was simulated numerically. The mathematical model takes into account the compet... | ['Chromatography, Thin Layer', 'Computers', 'Enzymes', 'Fluoresceins', 'Galactosides', 'Hydrolysis', 'Kinetics', 'Spectrometry, Fluorescence'] | 6,614,449 | [['E05.196.181.400.537'], ['L01.224.230.260'], ['D08.811'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D09.408.320'], ['G02.380'], ['G01.374.661', 'G02.111.490'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Glycolysis for Microbiome Generation. | For a generation of microbiologists who study pathogenesis in the context of the human microbiome, understanding the diversity of bacterial metabolism is essential. In this chapter, I briefly describe how and why I became, and remain, interested in metabolism. I then will describe and compare some of the strategies use... | ['Bacteria', 'Fermentation', 'Glycolysis', 'Host-Pathogen Interactions', 'Humans', 'Microbiota', 'Pentose Phosphate Pathway'] | 26,185,089 | [['B03'], ['G02.111.158.249', 'G03.191.249'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['G06.462', 'G16.527.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['G02.111.158.875', 'G03.191.875', 'G03.295.693', 'G03.493.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Potential public health benefits from cat eradications on islands. | Cats (Felis catus) are reservoirs of several pathogens that affect humans, including Toxoplasma gondii. Infection of pregnant women with T. gondii can cause ocular and neurological lesions in newborns, and congenital toxoplasmosis has been associated with schizophrenia, epilepsy, movement disorders, and Alzheimer's dis... | ['Animals', 'Cat Diseases', 'Cats', 'Female', 'Humans', 'Islands', 'Population Control', 'Pregnancy', 'Public Health', 'Toxoplasmosis, Animal', 'Toxoplasmosis, Congenital'] | 30,763,304 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.500.275.505', 'N06.230.295', 'Z01.639'], ['I01.240.600.650', 'N01.224.625.650', 'N06.850.505.400.700.650'], ['G08.686.784.769'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['C01.610.701.688... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Comparison of the antiemetic effects of a 5-HT1A agonist, LY228729, and 5-HT3 antagonists in the pigeon. | Vomiting may be induced by a variety of agents such as drugs, oncolytics, and provocative motion, as well as being conditioned to occur to environmental stimuli. Such emesis has recently been shown to be blocked by agonists at the 5-HT1A subtype of serotonin receptor. The antiemetic effects of LY228729 [(-)-4-(dipropyl... | ['Animals', 'Antiemetics', 'Columbidae', 'Dose-Response Relationship, Drug', 'Emetics', 'Ergolines', 'Male', 'Serotonin Antagonists', 'Serotonin Receptor Agonists', 'Vomiting'] | 8,545,476 | [['B01.050'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['B01.050.150.900.248.165.150'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.696.329', 'D27.505.696.663.050.225', 'D27.505.954.427.270', 'D27.505.954.483.560'], ['D03.132.327.287', 'D03.633.400.439'], ['D27.505.519.625.850.85... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Common risk factors in adolescent suicide attempters revisited. | The principle risk factors for suicide attempts in adolescents discussed in the literature are examined on the basis of data from a study carried out at the Geneva University Hospitals. 148 adolescents aged between 15 and 19 years form the sample. The results concerning mental disorders at the time of the suicide attem... | ['Adolescent', 'Adolescent Behavior', 'Adult', 'Female', 'Humans', 'Male', 'Risk Factors', 'Suicide, Attempted'] | 10,365,501 | [['M01.060.057'], ['F01.145.022'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['F01.145.126.980.875.600', 'I01.880.735.856.600']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Mineralization in vitro of matrix formed by osteoblasts isolated by collagenase digestion. | Osteoblasts from calvaria of 18-day-old fetal Sprague-Dawley rats were isolated using a dissecting procedure followed by collagenase digestion. Freshly isolated or previously frozen cells were cultured for up to 4 weeks in a Dulbecco's modified Eagle's medium supplemented with 10% fetal calf serum and 50 micrograms/ml ... | ['Alkaline Phosphatase', 'Animals', 'Bone Matrix', 'Calcium Phosphates', 'Cell Separation', 'Cells, Cultured', 'Collagen', 'Fibroblasts', 'Fluorescent Antibody Technique', 'Glycerophosphates', 'Microbial Collagenase', 'Microscopy, Electron', 'Microscopy, Electron, Scanning', 'Osteoblasts', 'Osteogenesis', 'Rats', 'Rats... | 2,995,186 | [['D08.811.277.352.650.035'], ['B01.050'], ['A10.165.265.166'], ['D01.029.260.700.675.374.075', 'D01.146.360', 'D01.695.625.675.650.075'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.329.228'], ['E01.370.225.500.607.512.240', 'E01.370.225.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thromboplastic and fibrinolytic activities of cultured human cancer cell lines. | Thromboplastic and fibrinolytic activities of 14 lines of cultured human cancer cells were estimated by modified Astrup's methods. High tissue thromboplastic activity was found in one line of urinary-bladder cancer, 2 lines of gastric cancer and one line of lung cancer, but no activity was found in 6 lines of lung canc... | ['Blood Coagulation', 'Cell Line', 'Factor IX', 'Factor VII', 'Fibrinolysis', 'Humans', 'Lung Neoplasms', 'Neoplasms', 'Stomach Neoplasms', 'Thromboplastin', 'Urinary Bladder Neoplasms'] | 758,928 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health care workers' hand decontamination practices: an Irish study. | The primary purpose of this quasi-experimental research is to observe health care workers' compliance with hand-hygiene guidelines during patient care in an intensive care unit in Ireland before (pretest) and after (posttest) implementation of a multifaceted hand-hygiene program. Health care workers' attitudes, beliefs... | ['Attitude of Health Personnel', 'Audiovisual Aids', 'Chi-Square Distribution', 'Effect Modifier, Epidemiologic', 'Guideline Adherence', 'Hand Disinfection', 'Health Knowledge, Attitudes, Practice', 'Hospitals, University', 'Humans', 'Inservice Training', 'Intensive Care Units', 'Ireland', 'Models, Educational', 'Model... | 16,410,620 | [['F01.100.050', 'N05.300.100'], ['J01.897.280.500', 'L01.178.820.090'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N05.715.350.350', 'N06.850.490.734'], ['N04.761.337', 'N05.715.360.395'], ['N06.850.670.150.500'], ['F01.100.150.500', 'N05.300.150.410'], ['N02.278.02... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographic... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Venous thromboembolism risk and postpartum lying-in: Acculturation of Indian and Chinese women. | OBJECTIVE: many cultures have a set time of traditional rest in the postpartum period. There is limited information on how this activity may potentially increase the risk of venous thromboembolism (VTE). We aimed to investigate VTE risk by determining the prevalence of the cultural practice of postpartum "lying-in", qu... | ['Acculturation', 'Adolescent', 'Adult', 'Australia', 'China', 'Cohort Studies', 'Female', 'Humans', 'Immobilization', 'India', 'Middle Aged', 'Postnatal Care', 'Pregnancy', 'Prevalence', 'Prospective Studies', 'Risk Factors', 'Surveys and Questionnaires', 'Tertiary Care Centers', 'Venous Thromboembolism'] | 29,275,264 | [['I01.076.201.450.050', 'I01.880.853.100.079'], ['M01.060.057'], ['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['Z01.252.474.164'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.472'], ['Z01.252.245.393'], ['M01.060.116.630'... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons. | The neurokinin-1 receptor and its tachykinin neuropeptide ligand substance P are associated with the mediation of nociception. Substance P released from primary afferent sensory neurons activates neurokinin receptors on both central and peripheral targets that mediate specific aspects of central sensitization and infla... | ['Animals', 'Central Nervous System', 'Formaldehyde', 'In Situ Hybridization', 'Male', 'Neuritis', 'Neurons, Afferent', 'Peripheral Nervous System', 'Plasmids', 'RNA Probes', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Neurokinin-1', 'Receptors, Neurokinin-3', 'Ribonucleases', 'Substance P', 'Tissue D... | 10,430,499 | [['B01.050'], ['A08.186'], ['D02.047.407'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['C10.668.829.650'], ['A08.675.650', 'A11.671.650'], ['A08.800'], ['G05.360.600'], ['D13.444.600.723', 'D27.505.259.750.600.825', 'D27.720.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding. | Diosgenin is a steroidal sapogenin with antitumor properties. We previously showed that diosgenin induced apoptosis in human erythroleukemia (HEL) cells. In order to elucidate the mechanism of its apoptotic activity, we investigated the effect of diosgenin on nuclear factor-kappaB (NF-kappaB) binding and on three group... | ['Apoptosis', 'Caspase 3', 'Caspases', 'Cell Line, Tumor', 'Cyclooxygenase 2', 'DNA Fragmentation', 'Diosgenin', 'Enzyme Activation', 'Humans', 'Imidazoles', 'K562 Cells', 'MAP Kinase Signaling System', 'NF-kappa B', 'Phytosterols', 'Poly(ADP-ribose) Polymerases', 'Pyridines', 'p38 Mitogen-Activated Protein Kinases'] | 16,273,292 | [['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.251.210.190', 'A11.251.860.180'], ['D08.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anatomic and sexual outcomes after vaginoplasty using tissue-engineered biomaterial graft in patients with Mayer-Rokitansky-K?ster-Hauser syndrome: a new minimally invasive and effective surgery. | INTRODUCTION: Recent years have seen continuous reports about the successful reconstruction of numerous organs with the application of tissue-engineering techniques. Thus, we assess the outcomes for vagina reconstruction using tissue-engineered biological material, which we suggested previously as an ideal graft for va... | ['46, XX Disorders of Sex Development', 'Acellular Dermis', 'Adult', 'Biocompatible Materials', 'Body Image', 'Case-Control Studies', 'China', 'Congenital Abnormalities', 'Female', 'Gynecologic Surgical Procedures', 'Humans', 'Mullerian Ducts', 'Patient Satisfaction', 'Prospective Studies', 'Reconstructive Surgical Pro... | 23,510,210 | [['C12.706.316.064', 'C13.351.875.253.064', 'C16.131.939.316.064', 'C19.391.119.064'], ['A17.815.180.040'], ['M01.060.116'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['F01.752.747.792.110', 'F02.463.593.112'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474.164'], ... | ['Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells. | BACKGROUND: Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most lethal cancers and often associated with a high accumulation of ROS. Recent studies identified gold... | ['Apoptosis', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Proliferation', 'Densitometry', 'Deoxycytidine', 'Drug Resistance, Neoplasm', 'Free Radical Scavengers', 'Homeostasis', 'Humans', 'Inhibitory Concentration 50', 'MAP Kinase Kinase Kinase 5', 'MAP Kinase Signaling System', 'Organogold Compounds', 'Oxidati... | 25,253,202 | [['G04.146.954.035'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.196.712.224'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['G07.690.773.984.395'], ['D27.505.519.217.500'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of extrusion of peas (Pisum sativum) on the intestinal flow of nitrogen in cows]. | Six Friesian heifers fed a 40% pea diet were used in a cross-over design. Ground and extruded peas were compared. Decreased nitrogen (N) solubility produced by extrusion was associated with an increase in non-ammonia-N flow (+ 36%; P less than 0.001) resulting from improvements in bacterial N flow (+ 53%; P less than 0... | ['Animals', 'Cattle', 'Duodenum', 'Fabaceae', 'Female', 'Food Handling', 'Nitrogen', 'Plants, Medicinal'] | 2,206,311 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A03.556.124.684.124', 'A03.556.875.249'], ['B01.650.940.800.575.912.250.401'], ['J01.576.423.200'], ['D01.268.604', 'D01.362.625'], ['B01.650.560']] | ['Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Presynaptic nigro-striatal function in a group of Alzheimer's disease patients with parkinsonism: evidence from a dopamine transporter imaging study. | The occurrence of parkinsonism in Alzheimer's disease (AD) is quite common, however the molecular and neurochemical changes underlying such extrapyramidal features in AD have been not fully understood. Post-mortem as well as in vivo imaging study have produced conflicting results as regards the existence of dopaminergi... | ['Aged', 'Alzheimer Disease', 'Basal Ganglia Diseases', 'Diagnosis, Differential', 'Dopamine Plasma Membrane Transport Proteins', 'Female', 'Humans', 'Lewy Body Disease', 'Male', 'Membrane Glycoproteins', 'Membrane Transport Proteins', 'Neostriatum', 'Nerve Tissue Proteins', 'Parkinson Disease', 'Radiopharmaceuticals',... | 15,254,794 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['C10.228.140.079'], ['E01.171'], ['D12.776.157.530.450.625.124', 'D12.776.157.530.562.374.500.500', 'D12.776.157.530.937.500', 'D12.776.543.585.450.625.124', 'D12.776.543.585.562.374.500.500', 'D12.776.543.585.937.500'], ['B01.050.150... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Somatostatin co-localizes with tyrosine hydroxylase in the nerve cells of discrete hypothalamic regions in rats. | The co-expression of somatostatin (SOM)- and tyrosine hydroxylase (TH)-like immunoreactivities in nerve cells of the rat hypothalamus was investigated by the simultaneous application to the same sections of immuno-beta-galactosidase staining and the peroxidase-antiperoxidase (PAP) method. SOM-like immunoreactive cells ... | ['Animals', 'Hypothalamus', 'Immunohistochemistry', 'Male', 'Rats', 'Rats, Inbred Strains', 'Somatostatin', 'Staining and Labeling', 'Tyrosine 3-Monooxygenase', 'beta-Galactosidase'] | 1,694,711 | [['B01.050'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['B01.050.150.900.... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease. | PURPOSE: We have shown previously that oral feeding of green tea polyphenols (GTP) to transgenic adenocarcinoma of the mouse prostate mice in a purely chemopreventive setting significantly inhibits prostate cancer development. To translate this to a human situation, the present study was designed to identify the stage ... | ['Adenocarcinoma', 'Animals', 'Anticarcinogenic Agents', 'Disease Models, Animal', 'Female', 'Flavonoids', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Magnetic Resonance Imaging', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Neoplasm Staging', 'Phenols', 'Polyphenols', 'Prostatic Intraepi... | 19,276,266 | [['C04.557.470.200.025'], ['B01.050'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D12.776.157.420.270'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Propofol causes neurite retraction in neurones. | BACKGROUND: The mechanism by which anaesthetic agents produce general anaesthesia is not yet fully understood. Retraction of neurites is an important function of individual neurones and neural plexuses during normal and pathological conditions, and it has been shown that such a retraction pathway exists in developing a... | ['Anesthetics, Intravenous', 'Animals', 'Bicuculline', 'Cells, Cultured', 'Cerebral Cortex', 'Dose-Response Relationship, Drug', 'GABA Antagonists', 'Heterocyclic Compounds, 4 or More Rings', 'Neurites', 'Phalloidine', 'Propofol', 'Rats', 'Rats, Sprague-Dawley'] | 18,587,139 | [['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['B01.050'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.625.240.300', 'D27.505.696.577.240.300'], ['D03.633.400'], ['A08.675.256.500', 'A08.675.54... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Symptomatic hyperparathyroidism. | In view of our last 100 patients operated on for hyperparathyroidism we found the following: 1. The operation is safe, with no mortality and a 2 per cent morbidity from transient hypoparathyroidism. 2. The operation is effective (99 per cent in our series) with removal of only clinically enlarged glands. 3. Most patien... | ['Age Factors', 'Aged', 'Arteriosclerosis', 'Calcium', 'Diabetes Complications', 'Female', 'Humans', 'Hypercalcemia', 'Hyperparathyroidism', 'Hypertension', 'Male', 'Middle Aged', 'Obesity', 'Parathyroid Glands', 'Sex Factors'] | 7,071,690 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C14.907.137.126'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C19.246.099'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.174.451', 'C18.452.950.340'], ['C19.642.355'], ['C14.907.489'], ['M01.060.116.630'], ['C18.654.726.500', '... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Do Latin American scientific journals follow dual-use review policies? | During the past decade, a number of journals have implemented dual-use policies in order to analyze whether the papers submitted for publication could raise concern because of the potential for misuse of their content. In this context, an analysis was performed on Latin American scientific journals to examine whether t... | ['Biological Science Disciplines', 'Bioterrorism', 'Editorial Policies', 'Latin America', 'Peer Review, Research', 'Periodicals as Topic'] | 24,693,885 | [['H01.158'], ['I01.198.240.856.800.100', 'I01.880.735.900.800.100', 'I01.880.735.950.500.226.100'], ['L01.737.484'], ['Z01.107.424'], ['F01.829.316.549.700', 'H01.770.644.487', 'I01.880.604.640.700', 'L01.143.865.750', 'L01.737.640', 'N03.706.700.700'], ['L01.178.682.829.678']] | ['Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
The revised ACGME laparoscopic operative requirements: how have they impacted resident education? | BACKGROUND: Laparoscopic surgery has been an essential component of surgical education for the last two decades. The Accreditation Council for Graduate Medical Education (ACGME) changed the requirements for laparoscopic cases beginning with graduates in 2008, and the Fundamentals of Laparoscopic Surgery program was int... | ['Clinical Competence', 'General Surgery', 'Humans', 'Internship and Residency', 'Laparoscopy', 'Practice Guidelines as Topic', 'Surveys and Questionnaires', 'United States'] | 22,234,586 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.810.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['E01.370.388.250.520', 'E04.502.250.520'], ['N04.761.700.350.650', 'N05.700.350.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.98... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Assessing the role of presuturing on wound closure. | The efficacy of presuturing was tested by quantitating the tissue gains for standardized wounds in a white swine piglet (9 to 11-kg) model. Also measured were the changes in wound closure tension for the wounds. Measurements were carried out at 1, 4, 17, 24, 48, and 72 hours in a total of 20 piglets. Presuturing was ca... | ['Animals', 'Evaluation Studies as Topic', 'Skin Physiological Phenomena', 'Stress, Mechanical', 'Suture Techniques', 'Swine', 'Tissue Expansion', 'Wounds and Injuries'] | 8,628,776 | [['B01.050'], ['E05.337', 'N05.715.360.335'], ['G13.750'], ['G01.374.835'], ['E04.987.775'], ['B01.050.150.900.649.313.500.880'], ['E04.680.800'], ['C26']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Multiple skull metastases from hepatocellular carcinoma successfully treated with radiotherapy. | We report a Japanese man who presented with multiple cranial nerve palsies with hepatitis B virus-related multiple hepatocellular carcinoma (HCC). He presented with right III, IV, VI, IX, X, and XII cranial nerve palsies. Metastases involving the clivus and the right occipital bone from HCC were diagnosed by the findin... | ['Aged', 'Carcinoma, Hepatocellular', 'Humans', 'Liver Neoplasms', 'Male', 'Skull Neoplasms', 'Treatment Outcome'] | 21,139,306 | [['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['C04.588.149.721', 'C05.116.231.754'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Liver microsomal bilirubin UDP-glucuronyltransferase disturbances in bile duct ligated rats. | The activity of bilirubin UDP-Glucuronyltransferase was determined in microsomes from normal and bile duct ligated rats. It was measured after 2 and 8 days following bile duct ligation and compared with normal rats. A decrease of 33% in the total enzyme activity was observed on day 2; a fall of 70% was founded on day 8... | ['Animals', 'Bilirubin', 'Cholestasis, Extrahepatic', 'Glucuronosyltransferase', 'Male', 'Microsomes, Liver', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 3,927,901 | [['B01.050'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['C06.130.120.135.150'], ['D08.811.913.400.450.480'], ['A11.284.835.540.541'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. | Abstract An interdisciplinary and international group of clinicians and scientists gathered in Philadelphia, PA, to attend the fourth International Research Conference on Multiple Hereditary Exostoses (MHE), a rare and severe skeletal disorder. MHE is largely caused by autosomal dominant mutations in EXT1 or EXT2, gene... | ['Animals', 'Biomedical Research', 'Bone Neoplasms', 'Chondrosarcoma', 'Congresses as Topic', 'Exostoses, Multiple Hereditary', 'Growth Disorders', 'Humans', 'N-Acetylglucosaminyltransferases', 'Neoplasm Proteins', 'Philadelphia'] | 24,409,815 | [['B01.050'], ['H01.770.644.145'], ['C04.588.149', 'C05.116.231'], ['C04.557.450.565.280', 'C04.557.450.795.300'], ['N03.540.199'], ['C04.557.450.565.575.610.615.325', 'C04.700.330', 'C05.116.099.708.670.615.325', 'C05.116.540.310.500', 'C16.320.700.330'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
[Towards a new Tunisian Medical Code of Deontology]. | The Medical Code of Deontology is a legal text including the physician's duties towards his patients, colleagues, auxiliaries and the community. Considering the scientific, legal and social changes, the deontology code should be revised periodically. The first Tunisian Medical Code of Deontology (TMCD) was promulgated ... | ['Codes of Ethics', 'Ethics, Medical', 'Tunisia'] | 20,517,844 | [['K01.752.566.479.068', 'K01.752.566.479.171.066', 'N04.761.700.350.324', 'N05.350.213', 'N05.350.340.080', 'N05.700.350.324'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['Z01.058.266.887']] | ['Humanities [K]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Thyroid-stimulating hormone and thyroglobulin levels decrease with chronological age in children and adolescents. | TSH, thyroglobulin (Tg), and the free T4 index were determined and related to chronological age in 24 normal boys (aged 7.6-17.6 yr; mean, 12.6 +/- 1.5 yr) and 20 normal girls (aged 7.8-17.0 yr; mean, 12.2 +/- 1.4 yr). There was no significant (P greater than 0.1) difference in mean serum TSH (3.06 +/- 2.07 vs. 2.97 +/... | ['Adolescent', 'Aging', 'Child', 'Female', 'Humans', 'Male', 'Thyroglobulin', 'Thyrotropin', 'Thyroxine'] | 6,847,868 | [['M01.060.057'], ['G07.345.124'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.377.856', 'D12.776.395.768', 'D12.776.486.706'], ['D06.472.699.631.525.883', 'D12.644.548.691.525.883'], ['D06.472.931.812', 'D12.125.072.050.767']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Unjailing of the septal perforator using a rotational atherectomy device prior to alcohol septal ablation in a patient with symptomatic hypertrophic obstructive cardiomyopathy. | We report a novel approach in which successful unjailing of the septal perforator was performed through the side branch of a coronary stent using a rotational atherectomy device for the purpose of alcohol septal ablation in a patient with symptomatic hypertrophic obstructive cardiomyopathy. | ['Aged, 80 and over', 'Atherectomy, Coronary', 'Cardiac Catheterization', 'Cardiomyopathy, Hypertrophic', 'Echocardiography', 'Equipment Design', 'Ethanol', 'Female', 'Heart Septum', 'Humans'] | 24,740,801 | [['M01.060.116.100.080'], ['E02.148.050.120.125', 'E04.100.376.719.125', 'E04.100.814.529.124.120.125', 'E04.100.814.529.968.060', 'E04.502.382.124.120.125', 'E04.502.382.968.060', 'E04.928.220.520.110', 'E05.157.016.120.125'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['C14.280.238.100', 'C14.280.484.048.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of hydroxyapatite nanoparticles on MII-stage porcine oocytes vitrification and the study of its mechanism]. | Nano-cryopreservation may become a new way in the next generation of cryopreservation technology. However, research using nanoparticles in oocytes vitrification has not been reported in the literature. In this study, HA nanoparticles with different diameters were added into cryoprotectant and M II-stage porcine oocytes... | ['Animals', 'Cell Survival', 'Cryopreservation', 'Cryoprotective Agents', 'Durapatite', 'Female', 'Fertilization in Vitro', 'Metaphase', 'Nanoparticles', 'Oocytes', 'Swine', 'Vitrification'] | 24,059,057 | [['B01.050'], ['G04.346'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D27.505.696.706.320', 'D27.720.799.180'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.69... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 2). Testicular toxicity in rats treated orally with ethinylestradiol for 2 weeks. | Parameters of ethinylestradiol-induced testicular toxicity were evaluated with organ weight determination, histopathological examination and quantitative morphometry. Male Sprague-Dawley rats were administered ethinylestradiol orally at 3 or 10 mg/kg/day for 2 weeks and 3 mg/kg/day for 4 weeks. Final body weights in al... | ['Administration, Oral', 'Animals', 'Apoptosis', 'Body Weight', 'DNA', 'Estradiol Congeners', 'Ethinyl Estradiol', 'Immunoenzyme Techniques', 'In Situ Nick-End Labeling', 'Male', 'Organ Size', 'Proliferating Cell Nuclear Antigen', 'Prostate', 'Rats', 'Rats, Sprague-Dawley', 'Seminal Vesicles', 'Testis', 'Toxicity Tests... | 11,349,453 | [['E02.319.267.100'], ['B01.050'], ['G04.146.954.035'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D13.444.308'], ['D06.472.334.851.437'], ['D04.210.500.668.651.568.291', 'D06.472.334.851.437.968.500'], ['E05.478.566.350', 'E05.478.583.400', 'E... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Doppler hemodynamic characteristics of four widely used aortic valve prostheses. | Fifty-one patients with normofunctioning aortic prosthetic heart valves were evaluated by Doppler-Echocardiography to determine type-related flow characteristics. The four mechanical valves tested were: Starr-Edwards (1200-1260 aortic), Bjork-Shiley (60 degrees-60 degrees cc aortic), Medtronic-Hall (aortic) and St. Jud... | ['Adolescent', 'Adult', 'Aged', 'Aortic Valve', 'Echocardiography, Doppler', 'Evaluation Studies as Topic', 'Female', 'Heart Valve Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Design', 'Regional Blood Flow', 'Regression Analysis'] | 2,093,848 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A07.541.510.110'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['E05.337', 'N05.715.360.335'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.320.550'... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): quantity, frequency, and timing of drinking. | BACKGROUND: Concise, accurate measures of maternal prenatal alcohol use are needed to better understand fetal alcohol spectrum disorders (FASD).METHODS: Measures of drinking by mothers of children with specific FASD diagnoses and mothers of randomly-selected controls are compared and also correlated with physical and c... | ['Adult', 'Alcohol Drinking', 'Anthropometry', 'Binge Drinking', 'Central Nervous System Depressants', 'Data Interpretation, Statistical', 'Ethanol', 'Executive Function', 'Female', 'Fetal Alcohol Spectrum Disorders', 'Humans', 'Infant, Newborn', 'Intelligence Tests', 'Mothers', 'Neuropsychological Tests', 'Pregnancy',... | 23,932,841 | [['M01.060.116'], ['F01.145.317.269'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['C25.775.100.437', 'F01.145.317.269.500', 'F03.900.100.550'], ['D27.505.696.277', 'D27.505.954.427.210'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['D02.033.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Choanal atresia: an unusual serious complication of complementary and alternative medical treatment. | The use of complementary and alternative medicine (CAM) is common among patients with chronic, long-standing nasal disease. Complications resulting from inappropriate CAM practices are sometimes reported, but serious complications such as choanal atresia and stenosis are rare. We report a case of choanal atresia and st... | ['Adult', 'Cautery', 'Choanal Atresia', 'Complementary Therapies', 'Constriction, Pathologic', 'Endoscopy', 'Humans', 'Male', 'Nasal Obstruction', 'Postoperative Complications', 'Tomography, X-Ray Computed'] | 12,707,198 | [['M01.060.116'], ['E02.154', 'E04.014.170'], ['C08.460.171', 'C08.695.271', 'C09.603.171', 'C16.131.740.271'], ['E02.190'], ['C23.300.287'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.460.525', 'C08.618.846.185.525', 'C09.603.525'], ['C23.550.767'], ['E01.370.350.350.810... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Differential effects of tumor necrosis factor-alpha and interleukin-1 on 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase expression in mouse Leydig cells. | Immune-endocrine interactions are important to the regulation of Leydig cell steroidogenesis. We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells. TNF and IL-1 both inhibit cAMP-st... | ['8-Bromo Cyclic Adenosine Monophosphate', 'Animals', 'Blotting, Northern', 'Cells, Cultured', 'Interleukin-1', 'Leydig Cells', 'Male', 'Mice', 'Multienzyme Complexes', 'Progesterone Reductase', 'RNA, Messenger', 'Radioimmunoassay', 'Steroid Isomerases', 'Testosterone', 'Tumor Necrosis Factor-alpha'] | 9,657,065 | [['D03.633.100.759.646.138.395.225', 'D13.695.462.200.225', 'D13.695.667.138.395.225', 'D13.695.827.068.395.225'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A11.251'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.46... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of revised Ionising Radiations Regulations. | New standards in ICRP60 led to the revision of the 1980 European Basic Safety Standards Directive, which in turn has created the necessity to revise the Ionising Radiations Regulations 1985. Proposals from the Health and Safety Commission (HSC) for revised regulations are currently out for public consultation in a form... | ['Europe', 'Humans', 'Maximum Allowable Concentration', 'Occupational Diseases', 'Occupational Exposure', 'Radiation Protection'] | 9,656,193 | [['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.210', 'N06.850.460.350.600.615'], ['C24'], ['N06.850.460.350.600'], ['N06.850.810.425']] | ['Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
T-cell receptor Vâ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. | Chronic idiopathic neutropenia (CIN) is a bone marrow (BM) disorder characterized by presence of activated T-lymphocytes in peripheral blood (PB) and BM. We investigated the pattern of T-cell responses in CIN by analyzing the T-cell receptor â-chain variable (Vâ) gene repertoire. Compared to controls, CIN patients disp... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Marrow', 'CD3 Complex', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Chronic Disease', 'Female', 'Flow Cytometry', 'Gene Rearrangement, beta-Chain T-Cell Antigen Receptor', 'Humans', 'Male', 'Middle Aged', 'Neutropenia', 'Receptors, Antigen, T-Cell, alpha-bet... | 20,864,416 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A15.382.216'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Suprapubic catheterisation with urethral closure (the Feneley procedure) in spinal cord injured men. | Three male spinal cord injured patients who underwent suprapubic catheterisation with urethral closure are reported. Although the procedure is well established in women, and has been mainly used in patients with multiple sclerosis, this simple procedure is also possible in men, and worth considering in difficult situat... | ['Adult', 'Catheters, Indwelling', 'Humans', 'Male', 'Middle Aged', 'Spinal Cord Injuries', 'Urethra', 'Urinary Catheterization'] | 8,835,033 | [['M01.060.116'], ['E07.132.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['A05.360.444.492.726', 'A05.810.876'], ['E01.370.390.820', 'E02.148.947', 'E05.157.500']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intracellular "activated" two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer. | The application of photodynamic therapy (PDT) for the diagnosis and treatment of cancer is hindered by the intrinsic defects of the currently available photosensitizers (PSs), such as poor water solubility and limited light-penetration depth. In this study, pH-responsive polymeric micelles that co-encapsulate therapeut... | ['Animals', 'Breast Neoplasms', 'Cell Line, Tumor', 'Chlorophyll', 'Drug Carriers', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Mice, Inbred BALB C', 'Micelles', 'Photochemotherapy', 'Photons', 'Photosensitizing Agents', 'Polymers', 'Reactive Oxygen Species', 'Tissue Distribution', 'Xenograft Model Antitumor Ass... | 28,860,747 | [['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D26.255.260', 'E02.319.300.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Carvedilol modifies antioxidant status of patients with stable angina. | The aim of this study was to evaluate the effect of carvedilol on the enzymatic antioxidative defence and plasma antioxidative activity in patients with stable angina. The study comprised 30 patients, aged 37-49 years with stable angina. Patients received carvedilol in escalating doses of 12.5 mg/24 h, 25 mg/24 h, and ... | ['Adult', 'Angina Pectoris', 'Antioxidants', 'Carbazoles', 'Carvedilol', 'Catalase', 'Erythrocytes', 'Female', 'Glutathione Peroxidase', 'Humans', 'Male', 'Middle Aged', 'Propanolamines', 'Superoxide Dismutase'] | 18,026,857 | [['M01.060.116'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D03.633.100.473.144', 'D03.633.300.148'], ['D02.033.100.624.151', 'D02.033.755.624.151', 'D02.092.063.624.151', 'D03.633.100.473.144.125', 'D03.633.300.148.125'], ['D08.8... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between dental state and dietary intake in 70-year-old males and females in G?teborg, Sweden: a population study. | A representative sample of 368 70-year-old males and females in G?teborg, Sweden, participated in an odontological examination and a dietary interview. The aim of the study was to relate dental state to dietary habits and, furthermore, to study the possible influence of some social factors on these relations. The degre... | ['Aged', 'Feeding Behavior', 'Female', 'Humans', 'Jaw, Edentulous, Partially', 'Male', 'Mastication', 'Oral Health', 'Sex Factors', 'Socioeconomic Factors', 'Sweden'] | 6,960,162 | [['M01.060.116.100'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.480.450', 'C07.320.550.450', 'C07.465.550.425.450', 'C07.793.597.425.450'], ['G07.203.650.283.500', 'G10.261.330.500'], ['N01.400.535'], ['N05.715.350.675', 'N06.850.490.875'], ['I01.8... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gene silencing of selected calcium-signalling molecules in a Drosophila cell line using double-stranded RNA interference. | Using the Drosophila melanogaster S2 cell line, stably expressing a cloned muscarinic acetylcholine receptor (AChR), DM1, we have applied gene silencing by double-stranded RNA interference (RNAi) to knock down gene products involved in DM1-mediated calcium signalling. We have shown that RNAi knock down of either the in... | ['Animals', 'Calcium Signaling', 'Calcium-Transporting ATPases', 'Cell Line', 'Drosophila melanogaster', 'Gene Silencing', 'RNA Interference', 'RNA, Double-Stranded', 'Sarcoplasmic Reticulum Calcium-Transporting ATPases'] | 14,706,287 | [['B01.050'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D08.811.277.040.025.314.250', 'D12.776.157.530.450.250.500', 'D12.776.157.530.813.250', 'D12.776.543.585.450.250.500', 'D12.776.543.585.813.250'], ['A11.251.210'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.308.203.374'], ['G... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of Wearable Technology in Remote Evaluation of Acute Stroke Patients: Feasibility and Reliability of a Google Glass-Based Device. | BACKGROUND: Telestroke is an efficient, cost-effective way to standardize care and improve access to immediate neurologic expertise for rural hospitals and other underserved areas. Hands-free wearable technology potentially allows for faster evaluations that fit easily within prehospital workflows and could improve pre... | ['Adult', 'Aged', 'Disability Evaluation', 'Feasibility Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Observer Variation', 'Predictive Value of Tests', 'Prognosis', 'Remote Consultation', 'Reproducibility of Results', 'Smart Glasses', 'Stroke', 'Videoconferencing', 'Workflow'] | 31,296,476 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.400'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.318.370.800.650', 'N05.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice. | While it has become clear that X-inactivation in the female soma is complete in mouse (in contrast to being "patchy" in man), the degree of X-inactivation in the testes has not been ascertained. We have compared autosomal and X-linked zinc finger homolog expression and X-linked and Y-linked zinc finger homolog methylat... | ['Animals', 'Base Sequence', 'DNA', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA-Binding Proteins', 'Dosage Compensation, Genetic', 'Gene Expression Regulation', 'Humans', 'Kruppel-Like Transcription Factors', 'Male', 'Methylation', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Polymerase Chain Reaction', '... | 8,318,216 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['D08.811.913.555.500.350.100.500'], ['D12.776.260'], ['G05.308.203.249'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.260.522', 'D12.776.930.375'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil. | We have previously purified and characterized two different S. cerevisiae enzymes that produce pseudouridine specifically in nucleotide positions 13 and 55, respectively, in their tRNA substrates. The interactions of these enzymes with fluorinated tRNAs have now been studied. Such RNAs were produced by in vitro transcr... | ['Base Sequence', 'Chromatography, Liquid', 'Cross-Linking Reagents', 'Fluorouracil', 'Intramolecular Transferases', 'Isomerases', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'RNA, Transfer', 'Saccharomyces cerevisiae', 'Substrate Specificity'] | 1,956,773 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.181.400'], ['D27.720.470.410.210'], ['D03.383.742.698.875.404'], ['D08.811.399.520'], ['D08.811.399'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.444.735.757'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['G02.111.835... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation. | Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of fungal growth and contribute to serious health problems in the developing world because of their toxicity and mutagenicity. Although relatively resistant to biotic degradation, aflatoxins can be metabolized by certain species o... | ['Aflatoxins', 'Bacterial Proteins', 'Catalysis', 'Kinetics', 'Models, Molecular', 'Molecular Sequence Data', 'Multigene Family', 'Mycobacterium', 'Oxidoreductases', 'Phylogeny', 'Protein Binding', 'Riboflavin'] | 20,807,200 | [['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['D12.776.097'], ['G02.130'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['B03.510.024.962.500', 'B03.510.460.400.410.552.552'], ['D08.811.682'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G02.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Eye movement abnormalities after a ruptured intracranial aneurysm. | OBJECTIVE: Overlooking eye movement abnormalities associated with aneurysmal subarachnoid hemorrhage (aSAH) is common, although these abnormalities may greatly affect quality of life. Their prevalence remains undetermined. The aim of the study was to assess preoperative and postoperative eye movement abnormalities and ... | ['Adult', 'Age Factors', 'Aged', 'Aneurysm, Ruptured', 'Cranial Nerve Diseases', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Aneurysm', 'Male', 'Middle Aged', 'Neurologic Examination', 'Ocular Motility Disorders', 'Prevalence', 'Prospective Studies', 'Sex Factors', 'Treatment Outcome'] | 24,755,465 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C14.907.055.185'], ['C10.292'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600', 'C14.907.055.635', 'C14.907.253.560.300... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanisms for accessing insoluble Fe(III) oxide during dissimilatory Fe(III) reduction by Geothrix fermentans. | Mechanisms for Fe(III) oxide reduction were investigated in Geothrix fermentans, a dissimilatory Fe(III)-reducing microorganism found within the Fe(III) reduction zone of subsurface environments. Culture filtrates of G. fermentans stimulated the reduction of poorly crystalline Fe(III) oxide by washed cell suspensions, ... | ['Bacteria', 'Electrons', 'Ferric Compounds', 'Iron Chelating Agents', 'Oxidation-Reduction', 'Solubility'] | 11,976,100 | [['B03'], ['G01.249.335', 'G01.358.500.750'], ['D01.490.100'], ['D27.505.519.914.500.410', 'D27.720.832.500.410'], ['G02.700', 'G03.295.531'], ['G02.805']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Allometric growth of the proglottids and strobila of the tapeworm, Hymenolepis diminuta. | HYMENOLEPIS DIMINUTA: adults were killed and fixed in fully extended positions, and the total lengths of the strobilae, numbers of proglottids, and distances of proglottids along the strobilae were determined. The relationship of proglottid number to distance along the strobila was exponential. Beginning at proglottid ... | ['Animals', 'Hymenolepis'] | 10,953,227 | [['B01.050'], ['B01.050.500.500.736.215.454']] | ['Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Resolving complex tandem repeats with long reads. | MOTIVATION: Resolving tandemly repeated genomic sequences is a necessary step in improving our understanding of the human genome. Short tandem repeats (TRs), or microsatellites, are often used as molecular markers in genetics, and clinically, variation in microsatellites can lead to genetic disorders like Huntington's ... | ['Genome, Human', 'Humans', 'Markov Chains', 'Microsatellite Repeats', 'Sequence Alignment', 'Sequence Analysis, DNA', 'Software'] | 25,028,725 | [['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500', 'N06.850.520.830.996.500'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.85... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation. | The X gene product of the human hepatitis B virus (HBx), a major factor responsible for hepatitis and hepatocellular carcinoma, modulates transactivation by a variety of transcription factors. Herein, expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene was found to be regulated transcriptionally by HBx thr... | ['Activating Transcription Factor 2', 'Alitretinoin', 'Binding Sites', 'CCAAT-Enhancer-Binding Proteins', 'Cyclic AMP Response Element-Binding Protein', 'HeLa Cells', 'Humans', 'Phosphoenolpyruvate Carboxykinase (GTP)', 'Promoter Regions, Genetic', 'Protein Binding', 'Receptors, Retinoic Acid', 'Retinoid X Receptors', ... | 11,042,264 | [['D12.776.260.108.061.750', 'D12.776.930.127.061.750'], ['D02.455.326.271.665.202.495.818.500.500', 'D02.455.426.392.368.367.379.249.700.860.500.500', 'D02.455.849.131.495.818.800.500', 'D02.455.849.291.925.500.500', 'D23.767.261.700.780.500'], ['G02.111.570.120'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.9... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of adrenomedullin on the isolated heart. | A novel peptide found in human blood, adrenomedullin (ADM), has been shown to have systemic vasodepressor activity in the rat. However, the direct effects of ADM on cardiac function are unknown. Results of the present study demonstrate that ADM13-52 possesses marked systemic vasodepressor activity in the anesthetized r... | ['Adrenomedullin', 'Anesthesia', 'Animals', 'Antihypertensive Agents', 'Blood Pressure', 'Female', 'Heart', 'In Vitro Techniques', 'Male', 'Peptides', 'Perfusion', 'Rats'] | 8,231,646 | [['D06.472.699.077', 'D12.644.548.017'], ['E03.155'], ['B01.050'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.541'], ['E05.481'], ['D12.644'], ['E05.680'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular dynamics simulations of chlorambucil/DNA adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen mustards. | The alkylation of DNA by chlorambucil has been studied using a computational approach. Molecular dynamics simulations were performed on the fully solvated non-covalent complex, two monoadducts and a crosslinked diadduct of chlorambucil with the d(CGG3G2CGC).-d(GCG1CCCG) duplex, in which the N7 atoms of G1, G2 and G3 ar... | ['Alkylation', 'Base Sequence', 'Chlorambucil', 'Computer Simulation', 'Cross-Linking Reagents', 'DNA', 'DNA Adducts', 'Mechlorethamine', 'Models, Chemical', 'Molecular Sequence Data', 'Molecular Structure', 'Nucleic Acid Conformation'] | 7,779,307 | [['G02.111.035', 'G02.607.094', 'G03.059'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D02.455.526.728.650.156'], ['L01.224.160'], ['D27.720.470.410.210'], ['D13.444.308'], ['D13.444.308.135', 'G05.200.104'], ['D02.455.526.728.650.529'], ['E05.599.495'], ['L01.453.245.667'], ['G02.111.570', 'G02.466']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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