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RTN1 Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene. This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in ...
MT-TR Mitochondrially encoded tRNA arginine also known as MT-TR is a transfer RNA which in humans is encoded by the mitochondrial MT-TR gene. # Structure The MT-TR gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 65 base pairs. The structure of a tRNA molecule is a distinct...
HAR1F HAR1F is a RNA gene which is part of a human accelerated region of the human genome. HAR1F is found on the long arm of chromosome 20 and the RNA product is expressed in Cajal-Retzius cells, where it colocalizes with the protein reelin. HAR1F was identified in August 2006 when human accelerated regions (HARs) were...
Dimethylarginine dimethylaminohydrolase Dimethylarginine dimethylaminohydrolase (DDAH) is an enzyme found in all mammalian cells. Two isoforms exist, DDAH I and DDAH II, with some differences in tissue distribution of the two isoforms). The enzyme degrades methylarginines, specifically asymmetric dimethylarginine (AD...
Thromboprophylaxis in Patients With COVID-19 BACKGROUND: Patients hospitalized with COVID-19 often exhibit markers of a hypercoagulable state and have an increased incidence of VTE. In response, CHEST issued rapid clinical guidance regarding prevention of VTE. Over the past 18 months the quality of the evidence has im...
GRIA3 Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. # Function Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes wit...
Sandbox/22 # Gas gangrene # CHF # Hypertension - ↑ Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristani FE; et al. (1986). "Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study". N Engl J Med. 314 (24): 1547–52. doi:10...
ProSavin ProSavin is an experimental drug believed to be of use in the treatment of Parkinson's Disease. It is administered to the striatum in the brain, inducing production of dopamine. It is manufactured by Oxford BioMedica, who plan to start European Phase I and Phase II clinical trials in 2007. Animal trials have b...
HLA-B27 Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents microbial antigens to T-cells. HLA-B27 strongly associated with a certain set of autoimmune diseases referred to as the "seronegativ...
Vertical direction In astronomy, geography, geometry and related sciences and contexts, a direction passing by a given point is said to be vertical if it is locally aligned with the gradient of the gravity field, i.e., with the direction of the gravitational force (per unit mass) at that point. # Discussion Although t...
Primula veris Primula veris (Cowslip; syn. Primula officinalis Hill) is a flowering plant in the genus Primula. The species is native throughout most of temperate Europe and Asia, and although absent from more northerly areas including much of north-westScotland, it reappears in northernmost Sutherland and Orkney. It i...
Endometrial polyp An endometrial polyp or uterine polyp is a polyp or lesion in the lining of the uterus (endometrium) that takes up space within the uterine cavity. Commonly occurring, they are experienced by up to 10% of women. They may have a large flat base (sessile) or be attached to the uterus by an elongated ped...
Isocitrate dehydrogenase Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosucci...
Striae (patient information) For the WikiDoc page for this topic, click here # Overview Striae are irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. Striae are commonly called stretch marks. # What are th...
Sp1 gene transcriptions Specificity protein 1 is Sp1. Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level. Withaferin A, a sterodial lacton...
PRDX6 Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of antioxidant enzymes. # Function The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sit...
Measles | Disease Directory | Travelers' Health | CDC ### What is measles? Measles is a disease caused by a highly contagious virus. People with measles spread the virus through the air when they cough, sneeze, or breathe.   [Symptoms](https://www.cdc.gov/measles/symptoms/signs-symptoms.html) of measles include high f...
Vesicular monoamine transporter # Overview The vesicular monoamine transporter is a transport protein located within the presynaptic cell. # Isoforms It comprises the two isoforms: - VMAT1 - VMAT2 # Substrates Substrates for the transporter is mainly noradrenaline, adrenaline and isoprenaline. However, other substra...
Tobacco and health # Overview The effects of tobacco on health are significant, depending on the way the tobacco is used (smoked, snuffed or chewed) and the amount. Major health effects of smoking, the most common use of tobacco, include an increased risk in lung cancer and cardiovascular disease. The World Health Org...
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancer Evidence-based recommendations on pembrolizumab (Keytruda) with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junc...
W box gene transcriptions "Consistent with its role as a transcriptional repressor, OsWRKY71 binds specifically to functionally defined TGAC-containing W boxes of the Amy32b promoter in electrophoretic mobility shift assays (Zhang et al. 2004)." "Details of auto-regulation or cross-regulation by WRKY factors were provi...
Telaprevir drug interactions # Drug Interactions ## Potential for INCIVEK to Affect Other Drugs INCIVEK is a strong inhibitor of CYP3A. Co-administration of INCIVEK with drugs that are primarily metabolized by CYP3A may result in increased plasma concentrations of such drugs, which could increase adverse reactions (s...
2C-T-15 2C-T-15 or 2,5-dimethoxy-4-(β-cyclopropylthio)phenethylamine is a psychedelic phenethylamine of the 2C family. It was presumably first synthesized by Alexander Shulgin and reported in his book PIHKAL. # Chemistry 2C-T-15 is the 2 carbon homologue of Aleph-15, which has not been synthesized. The full chemical...
Fluconazole dosage and administration # Dosage and Administration ### Dosage in Adults Single Dose - Vaginal candidiasis The recommended dosage of DIFLUCAN for vaginal candidiasis is 150 mg as a single oral dose. Multiple Dose SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF DIFLUCAN (FLUCONAZOLE...
Recovery, Inc. # Processes Recovery's method is essentially cognitive therapy; helping a person to be aware of possible errors or misconceptions in their perception of reality. Because its methods do not conflict with other therapies, it can be used in conjunction with twelve-step programs and is often recommended to ...
Mpemba effect The Mpemba effect is the observation that, in certain specific circumstances, warmer water freezes faster than colder water. New Scientist recommends starting the experiment with containers at 35°C and 5°C to maximise the effect. # Origin The effect is named for the Tanzanian high-school student Erasto B...
AHA 2015 Schedule Here is the page we will use to coordinate the TV events at AHA 2015. Open time slots are indicated below in red. Filming Location: Hyatt Regency Orlando, 9801 International Dr, Orlando, FL 32819, U.S.A. # Click on Date for Detailed Schedule Sunday, November 8, 2015 Monday, November 9, 2015 Tuesday, ...
Amantadine drug interactions # Drug Interactions Careful observation is required when amantadine hydrochloride is administered concurrently with central nervous system stimulants. Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine. Coadministration of thioridazine...
Interest (emotion) # Overview Interest (emotion) is a feeling or emotion that causes attention to focus on an object or an event or a process. In contemporary psychology of interest it is used as a general concept which encompasses other more specific emotion terms, such as curiosity and to a certain degree surprise,...
Summary of the Standards, Options and Recommendations for the management of patients with carcinoma of unknown primary site (2002) Carcinomas of unknown primary site are metastatic malignant epithelial tumours whose primary site cannot be identified during pretreatment assessment. They are characterised by their slow ...
ADAMTS7 A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15. It is ubiquitously expressed in many tissues and cell types. This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. AD...
Amphetamine psychosis # Overview Amphetamine psychosis is a form of psychosis which can result from amphetamine or methamphetamine use. Typically it appears after large doses or chronic use, although in rare cases some people may become psychotic after relatively small doses. Other chemicals or drugs which similarly i...
Enterocolitis Enterocolitis (or "coloenteritis") is an inflammation of the colon and small intestine. However, most conditions are categorfized as one or the other of the following: - Enteritis is the inflammation of the small intestine - Colitis is inflammation of the large intestine, especially the colon # Types Spe...
Transcutaneous electrical stimulation of the trigeminal nerve for ADHD Evidence-based recommendations on transcutaneous electrical stimulation of the trigeminal nerve for ADHD. This involves a single-use electrode patch stuck to the forehead, which sends small electrical pulses through the skin during sleep. # Recomm...
Tildrakizumab for treating moderate to severe plaque psoriasis Evidence-based recommendations on tildrakizumab (Ilumetri) for treating moderate to severe plaque psoriasis in adults. # Recommendations Tildrakizumab is recommended as an option for treating plaque psoriasis in adults, only if: the disease is severe, as ...
Interleukin 7 Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by normal lymph...
2-Hydroxyglutaric aciduria 2-hydroxyglutaric aciduria is a rare, autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid. # Forms 2-hydroxyglutaric aciduria is an organic aciduria, and has two distinct isometric variants: ## L-2-hydroxyglutaric ...
Anatomy Anatomy (from the Greek Template:Polytonic anatomia, from Template:Polytonic ana: separate, apart from, and temnein, to cut up, cut open) is a branch of biology that is the consideration of the structure of living things. It is a general term that includes human anatomy, animal anatomy (zootomy) and plant anat...
Rimantadine warnings and precautions # Warnings And Precautions GENERAL: An increased incidence of seizures has been reported in patients with a history of epilepsy who received the related drug amantadine In clinical trials of Flumadine, the occurrence of seizure-like activity was observed in a small number of patien...
# Summary: Lead exposure is a continuing urgent health problem for Roma in Kosovo. The Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO) and the United Nations International Children's' Emergency Fund (UNICEF) have collaborated in blood lead surveillance of the Roma children living i...
Niacin/lovastatin contraindications # Contraindications ADVICOR is contraindicated in patients with a known hypersensitivity to niacin, lovastatin or any component of this medication, active liver disease or unexplained persistent elevations in serum transaminases (see WARNINGS), active peptic ulcer disease, or arteri...
Hemoglobin # Overview Hemoglobin, also spelled haemoglobin and abbreviated Hb, is the iron-containing oxygen-transport metalloprotein in the red blood cells of the blood in vertebrates and other animals. In mammals the protein makes up about 97% of the red cell’s dry content, and around 35% of the total content (inclu...
Bursitis overview # Overview Bursitis is characterized by the inflammation of a bursa and the buildup of the fluid in the bursal sac. A bursa is a small, fluid-filled sac that acts as a cushion between a bone and other moving parts: muscles, tendons, or skin. Over 160 bursa are found throughout the body but relatively...
# Table of Contents I # I. Introduction Multidrug-resistant organisms (MDROs), including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and certain gram-negative bacilli (GNB) have important infection control implications that either have not been addressed or received only ...
Embryology of the gallbladder and the biliary tract Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3 Please help WikiDoc by adding content here. It's easy! Click here to learn about editing. # Overview # Historical Perspective - was first discovered by , a , in during/following . - In , mutations were first ...
Laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birth Evidence-based recommendations on laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birth. This involves placing a stitch around the upper part of the cervix to keep it closed. # Recommend...
FOXRED1 FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1), also known as H17, or FP634 is an enzyme that in humans is encoded by the FOXRED1 gene. FOXRED1 is an oxidoreductase and complex I-specific molecular chaperone involved in the assembly and stabilization of NADH dehydrogenase (ubiquinone) also ...
Growth hormone Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type of mitogen which is specific o...
Adaptive behavior # Overview Adaptive behavior is a type of behavior that is used to adapt to another type of behavior or situation. This is often characterized by a kind of behavior that allows an individual to substitute an unconstructive or disruptive behavior to something more constructive. These behaviors are mos...
Butorphanol Injection (patient information) # About your treatment Your doctor has ordered butorphanol, an analgesic (painkiller), to relieve your pain. The drug will be injected into a large muscle (such as your buttock or hip) or a vein. You will probably receive butorphanol every 3 to 4 hours as needed for pain. Yo...
Chiropractic - Economics Chiropractic Main Article Chiropractic is the largest alternative medical profession in the U.S. and is the 3rd largest doctoral profession behind only medicine and dentistry in North America. # Utilization and satisfaction rates The percentage of population that utilize chiropractic care at ...
Irreversible electroporation for primary liver cancer Evidence-based recommendations on irreversible electroporation for primary liver cancer in adults. This involves passing short electrical pulses of high-voltage current into the cancer cells. # Recommendations Evidence on the safety of irreversible electroporation...
Semantic memory # Overview Semantic memory refers to the memory of meanings, understandings, and other concept-based knowledge unrelated to specific experiences. The conscious recollection of factual information and general knowledge about the world, generally thought to be independent of context and personal relevanc...
Standing gradient osmosis # Overview Water absorption at the colon typically proceeds against a transmucosal osmotic pressure gradient. The standing gradient osmosis is a term used to describe the reabsorption of water against the osmotic gradiet at the colon. This hypertonic fluid creates an osmotic pressure that dri...
Dolutegravir # Disclaimer WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc ...
General guidelines on creating chapters and microchapters # Overview The following is a guide to creating your chapters and microchapters. A chapter is a collection of smaller chapters called microchapters. For instance, the disease pericarditis is a chapter composed of multiple microchapters such as pericarditis ov...
Sandbox:Parul This page is for your practice! Keywords and synonyms: Cerebral herniation, cerebellar herniation, uncal herniation, central herniation, supratentorial herniation, infratentorial herniation, transtentorial herniation, tonsillar herniation, cingulate herniation, transcalvarial herniation # Overview Hernia...
Multiple endocrine neoplasia (patient information) For the WikiDoc page for this topic, click here # Overview Multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of endocrine glands, each with its own characteristic pattern. Multiple endocrine neoplasia may be classified accordin...
Diffuse esophageal spasm overview # Overview Diffuse or Distal esophageal spasm (DES) is an uncommon esophageal motility disorder causing chest pain and/or dysphagia. DES was first described by Osgood, in 1889 in 6 patients presenting with chest pain and dysphagia. Creamer et al. (1958) made the first manometric descr...
Metallic hydrogen Metallic hydrogen results when hydrogen is sufficiently compressed and undergoes a phase change; it is an example of degenerate matter. Solid metallic hydrogen consists of a crystal lattice of atomic nuclei (namely, protons), with a spacing which is significantly smaller than a Bohr radius. Indeed, th...
Siponimod for treating secondary progressive multiple sclerosis Evidence-based recommendations on siponimod (Mayzent) for treating secondary progressive multiple sclerosis in adults. # Recommendations Siponimod is recommended, within its marketing authorisation, as an option for treating secondary progressive multipl...
INSIDE: Continuing Education Examination depar depar depar depar department of health and human ser tment of health and human ser tment of health and human ser tment of health and human ser tment of health and human services vices vices vices vices# Introduction Improving preconception health can result in improved rep...
The Living Guidelines: Prevention of thromboembolism in patients with atrial fibrillation undergoing cardioversion: Polling Results for CLASS IIa Guidelines # Class IIa Guidelines 1. During the first 48 h after onset of AF, the need for anticoagulation before and after cardioversion may be based on the patient’s risk ...
Eutherian fetoembryonic defense system (eu-FEDS) hypothesis The Eutherian Fetoembryonic Defense System (eu-FEDS) is a hypothetical model describing a method by which immune systems are capable of recognizing additional states of relatedness like "own species" such as is observed in maternal tolerance of a related fetus...
Valsartan - When pregnancy is detected, discontinue valsartan as soon as possible. - Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. ## Hypertension - Dosing information - Recommended starting dosage: 80 mg or 160 mg PO qd when used as monotherapy in patients...
Blunt trauma Synonyms and keywords: Blunt injury; non-penetrating trauma; blunt force trauma. # Overview In medical terminology, blunt trauma refers to a type of physical trauma caused to a body part, either by impact, injury or physical attack; the latter usually being referred to as blunt force trauma. The term itse...
Genetic fingerprinting # Overview Genetic Fingerprinting (also called DNA testing, DNA typing, or DNA profiling) is a technique used to distinguish between individuals of the same species using only samples of their DNA. Although two individuals will have the vast majority of their DNA sequence in common, DNA profili...
Hydrolysis constant A hydrolysis constant is an equilibrium constant for a hydrolysis reaction. For example, if a metal salt such as AlCl3 dissolves in an aqueous solution, the metal cation behaves as a Lewis acid and hydrolyzes the water molecules in the solvent. The hydrolysis constant for this reaction is: In a more...
Parvalbumin Parvalbumin is a calcium-binding albumin protein with low molecular weight (typically 9-11 kDa). It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine ti...
Gero-Informatics Gero-informatics (sometimes termed Geroinformatics) is the development, application, and study of health informatics in geriatrics. Whereas gerontechnology refers to "matching technological environments to health, housing, mobility, communication, leisure and work of older people", gero-informatics co...
Division of ankyloglossia (tongue-tie) for breastfeeding # Guidance Current evidence suggests that there are no major safety concerns about division of ankyloglossia (tongue-tie) and limited evidence suggests that this procedure can improve breastfeeding. This evidence is adequate to support the use of the procedure p...
Cannabinoids # Overview Cannabinoids are a group of terpenophenolic compounds present in Cannabis (Cannabis sativa L). The broader definition of cannabinoids refer to a group of substances that are structurally related to tetrahydrocannabinol (THC) or that bind to cannabinoid receptors. The chemical definition encompa...
The World Health Organization (WHO) convened a Guideline Development Group (GDG) meeting from to 31 July 2019 to review global guidance on contraceptive eligibility for women at high risk of HIV acquisition to and determine whether revisions to the fifth edition of the Medical eligibility criteria for contraceptive use...
SEOM clinical guidelines for anaemia treatment in cancer patients (2020) Anaemia is defined by the presence of haemoglobin (Hb) levels < 13 g/dL in men and 12 g/dL in women. Up to 39% of cancer patients present it at the time of diagnosis and up to 40% have iron deficiency. Anaemia causes fatigue, functional deteriora...
Recommendations for accurate CT diagnosis of suspected acute aortic syndrome (AAS)—on behalf of the British Society of Cardiovascular Imaging (BSCI)/British Society of Cardiovascular CT (BSCCT) # Introduction Timely and accurate assessment of suspected acute aortic syndrome (AAS) is vital in this potentially life-th...
COVID19 and acute lymphoblastic leukemias of children and adolescents: Updated recommendations (Version 2) of the Leukemia Committee of the French Society for the fight against Cancers and leukemias in children and adolescents (SFCE) d'hémato-immunologie pédiatrique, hôpital universitaire Robert-Debré (APHP), boulevar...
Raltegravir how supplied # How Supplied ## ISENTRESS tablets 400 mg ISENTRESS tablets 400 mg are pink, oval-shaped, film-coated tablets with "227" on one side. They are supplied as follows: NDC 0006-0227-61 unit-of-use bottles of 60. No. 3894 ## ISENTRESS tablets 100 mg ISENTRESS tablets 100 mg are pale orange, oval...
Data dredging Data dredging (data fishing, data snooping) is the inappropriate (sometimes deliberately so) search for 'statistically significant' relationships in large quantities of data. This activity was formerly known in the statistical community as data mining, but that term is now in widespread use with an essent...
Divalproex sodium contraindications # Contraindications Depakote should not be administered to patients with hepatic disease or significant hepatic dysfunction . Depakote is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG; e.g., Alpers-Hutte...
Spinal cord injury # Overview Spinal cord injury causes myelopathy or damage to white matter or myelinated fiber tracts that carry sensation and motor signals to and from the brain. It also damages gray matter in the central part of the spinal, causing segmental losses of interneurons and motorneurons. Spinal cord i...
miR-296 miR-296 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-296 has been named an "angiomiR" due to being characteris...
Drospirnone # Overview Drospirenone (INN, USAN), also known as 1,2-dihydrospirorenone, is synthetic, steroidal progestin with additional antimineralocorticoid and weak antiandrogen properties which is used as a hormonal contraceptive. It is sold under the brand names Yasmin, Yasminelle, Yaz, Beyaz, Ocella, Zarah, and ...
Triamcinolone Nasal Inhalation (patient information) # Why is this medication prescribed Triamcinolone, a corticosteroid, is used to prevent allergy symptoms including sneezing, itching, and runny or stuffed nose. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more informatio...
Reticular fiber # Overview Reticular fibers or reticulin is a histological term used to describe a type of structural fiber composed of type III collagen. Reticular fibers crosslink to form a fine meshwork (reticulum). This network acts as a supporting mesh in soft tissues such as liver, bone marrow, and the tissues a...
Ergogenic aid Ergogenic aids are any external influences which can positively affect physical or mental performance. These include mechanical aids, pharmacological aids, physiological aids, nutritional aids, and psychological aids. Ergogenic aids may directly influence the physiological capacity of a particular body sy...
CRABP2 Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. CRABP2 is structurally similar to CRABP1, but CRABP2 has a lower affinity for retinoic acid (RA). CRABP2 is associated with cells that produce large amounts of retinoic acid and may play a role...
Settled insanity Settled insanity is defined as a permanent or "settled" condition caused by long-term substance abuse and differs from the temporary state of intoxication. In some United States jurisdictions "settled insanity" can be used as a basis for an insanity defense, even though voluntary intoxication cannot, i...
Pentose # Overview A pentose is a monosaccharide with five carbon atoms. They either have an aldehyde functional group in position 1 (aldopentoses), or a ketone functional group in position 2 (ketopentoses). The aldopentoses have three chiral centres ("asymmetric carbon atoms") and so 8 different stereoisomers are p...
Evidence and recommendation on antenatal multiple micronutrient supplements 7 # Dissemination and implementation of the recommendation 20
Prostaglandin DP2 receptor Prostaglandin D2 receptor 2 (DP2 or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44. DP2 has also been designated as CD294 (cluster of differentiation 294). It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins. DP2 along w...
Chick slaughtering Chick slaughtering is the culling of newly hatched male chickens for which breeders have no use. In an industrial egg-producing facility, about half of the newly hatched chicks will be male and would grow up to be roosters, which do not lay eggs and therefore there is no incentive for the breeder to ...
Psilocybe azurescens Psilocybe azurescens is a psychedelic mushroom whose main active compounds are psilocybin and psilocin. It is among the most potent of the tryptamine-bearing mushrooms, containing up to 1.8% psilocybin, 0.5% psilocin, and 0.4% baeocystin by dry weight, averaging to about 1.1% psilocybin and 0.15% ...
Calponin 3, acidic Calponin 3. acidic is a protein that in humans is encoded by the CNN3 gene. The CNN3 gene is located at 1p22-p21 in the human chromosomal genome. CNN3 gene contains 7 exons and encodes calponin 3, a 36.4-kDa protein consisting of 329 amino acids with isoelectric point (pI) of 5.84. Calponin 3 is know...
Rifampin isoniazid indications and usage # Indications And Usage For pulmonary tuberculosis in which organisms are susceptible, and when the patient has been titrated on the individual components and it has therefore been established that this fixed dosage is therapeutically effective. This fixed-dosage combination dr...
Water model In computational chemistry, classical water models are used for the simulation of water clusters, liquid water, and aqueous solutions with explicit solvent. These models use the approximations of molecular mechanics. Many different models have been proposed; they can be classified by the number of points us...
Home remedy # Overview A home remedy is a treatment to cure a disease or ailment that employs certain spices, vegetables, or other common items from the kitchen. Home remedies may or may not have actual medicinal properties that serve to treat or cure the disease or ailment in question, as they are typically passed al...
Medieval demography Medieval demography is the study of human demography in Europe during the Middle Ages. It is an estimate of the number of people who were alive during the Medieval period, population trends and movements. In many ways, demography was one of the most crucial factors of historical change throughout th...
Complement component 3 Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3. # Function C3 plays a central role in the activation of complement...
Anatomical pathology Anatomical pathology (Commonwealth) or Anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the gross, microscopic, and molecular examination of organs, tissues, and cells. In many countries, physicians who practice pathology are trained in both ...
Laparoscopic surgery for inguinal hernia repair Evidence-based recommendations on laparoscopic surgery for treating inguinal hernia. # Guidance This guidance replaces 'Laparoscopic surgery for hernia' (NICE Technology Appraisal Guidance 18) issued in January 2001. For details, see 'About this guidance'. Laparoscopic ...