title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Properties of rat lens phosphofructokinase. | Two interconvertible forms of phosphofructokinase (PFK) have been eluted from a DEAE-cellulose column from the supernatant fraction of rat lens homogenates centrifuged at 96,000 x g for 1 hour at 0 to 4 degrees C. The interconversion can be manipulated by a change in the pH of the extracting and eluting buffers. PFK-I ... | 4,411 | [
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Control of inositol biosynthesis in Saccharomyces cerevisiae: properties of a repressible enzyme system in extracts of wild-type (Ino+) cells. | Inositol biosynthesis was studied in soluble, cell extracts of a wild-type (Ino) strain of Saccharomyces cerevisiae. Two reactions were detected: (i) conversion of D-glucose-6-phosphate to a phosphorylated form of inositol, presumably inositol-1-phosphate (IP synthethase, EC5.5.1.4), and (ii) conversion of phosphoryla... | 4,423 | [
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[Acute amebic abscess of the liver followed by colonic ulcers. Report of 2 cases]. | Two unusual cases of ruptured acute amebic liver abcess are presented one with inferior vena caval compression. Surgical drainage was followed by the development of colonic complications (haemorrhage and perforation) although the patients were under specific therapy. After a new surgical operation both cases were cured... | 4,462 | [
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Glucagon-sensitive adenylate cyclase in human renal medulla. | In cell-free preparations (washed 600 x g pellets) of human renal medulla, glucagon produced a dose-dependent stimulation of adenylate cyclase. The stimulation of renal medullary adenylate cyclase by saturating concentrations of glucagon was additive to the saturating doses of vasopressin. Furthermore, L-isoproterenol ... | 4,466 | [
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A kinetic concepto of lipid transport in ruminants. | Summarization of the literature shows a strong correlation between dietary fatty acid intake and total lipid concentration in plasma in lactating cows whereas total milk fat secreted is related to neither of these. In the process of plasma triglyceride removal, chylomicra and very low density lipoproteins are converted... | 4,477 | [
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Nonimmunologic aspects of caries resistance. | A variety of components provide salivary secretions with an array of potentially effective means of combating cariogenic challenges. These defense factors range from a laissez-faire mechanical cleansing to exquisitely controlled production of highly specific antibodies. In between the two extremes are antibacterial sys... | 4,481 | [
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Morphologic and biochemical changes in autolysing dog heart muscle. | The progressive changes in pH, lactate content, and light and electron microscopic appearances were studied in dog myocardium undergoing a 6-hour period of autolysis in vitro at 37 degrees C. and at room temperature. At 37 degrees C. there was a rapid cumulative fall in pH during the 1st hour after excision of the hear... | 4,649 | [
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The relationship between alcohol dosage and performance decrement in humans. | The effects of alcohol on human perceptual, cognitive and motor performance was assessed in a battery of tests, and the dose-response relationships for alcohol, important for the study of drug-alcohol interactions, established. | 4,663 | [
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[Cerebral palsy--early diagnosis and treatment (author's transl)]. | The main aim of the present Conference has been to debate that early diagnosis and treatment of cerebral palsy. The Conference was attended by specialists taking care of the child with cerebral palsy (C.P.): child neurologists, surgeons--orthopedists, psychologists, rehabilitants, pediatricians. In connection with the ... | 4,786 | [
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A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney. | Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostagland... | 4,794 | [
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Chemical reactivities of tetrapyrrole pigments: a comparison of experimentalbehaviour with the results of s.c.f.-pi-m.o. calculations. | Porphyrins are highly sigma-electron donating bases and very weak pi-acids. Hence they increase the electron density on central metal ions, e.g. iron, which leads to the specific reactivity of haem cytochromes, haemoglobin and oxidizing enzymes. The macrocyclic chlorin ligand behaves similarly but to a lesser degree w... | 4,842 | [
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Assessment of antipsychotic activity of an unique agent: SU-23397. | SU-23397 is a unique new hybrid molecule, the animal profile being characteristic of neuroleptic activity. Although the trial was uncontrolled, there appears to be no doubt that SU-23397 exerts antipsychotic activity between 20 mg and 250 mg daily in severely ill schizophrenic patients. Seven of the ten subjects requir... | 4,858 | [
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The search for the dopamine receptor: tribulations. | In an attempt to identify specific binding to dopamine receptors the binding of 3H-pimozide to preparations of brain and to an artificial cellulose membrane was examined. Binding occurred rapidly, was pH and temperature dependent, and was displaceable by other neuroleptics. Displaceable binding was saturable at 5 X 10(... | 4,861 | [
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Irreversible protein binding of norethisterone (norethindrone) epoxide. | 14,15-3H-Norethisterone-4 beta, 5 beta-epoxide, a metabolite of norethisterone, was incubated with several proteins and nucleic acids. After 30 min incubation 0.19 nmol of the epoxide were irreversibly bound per mg albumin which contains free sulfhydryl groups; proteins without SH-groups, such as concanavalin A, gamma-... | 4,905 | [
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A comparison of the cardiovascular effects of enflurane, halothane, methoxyflurane and fluroxene during open cardiac surgery. | During open heart surgery hemodynamic changes due to 1.5% enflurane, 0.75% halothane, 0.18% methoxyflurane and 3.4% fluroxene have been compared. The following parameters have been measured: arterial pressure, heart rate, cardiac output, right and left atrial pressure, left ventricular pressure and dp/dt. The strongest... | 4,951 | [
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Internal mammary artery bypass graft in reoperative myocardioal revascularization. | Thirty-two consecutive patients who earlier received indirect or direct myocardial revascularization underwent reoperation with one or more internal mammary artery grafts either alone or in combination with saphenous vein grafts. The main indication for reoperation was graft closure or progression of coronary atheroscl... | 4,970 | [
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Experiments on the role of virus infections in the pathogenesis of bronchial asthma. The role of innate or acquired insufficiency or ergotropic adaptation in the mechanism of genesis of bronchial asthma. | The wide mosaic of congruent clinical and experimental observations led to the postulation that the cause of the pharmacological abnormality of the asthmatic patient, i.e. the immensely increased reactivity of the bronchial smooth muscles, is to be sought in an insufficiency of the beta-adrenergic receptor system. It i... | 4,969 | [
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Cardiovascular effects of cerebroventricular ouabain perfusion in the adult dog. | Cerebroventricular perfusion with artificial cerebrospinal fluid containing 10(-5) M ouabain was performed in adult dogs in order to describe the time course of the cardiovascular effect of intraventricular ouabain and to evaluate treatments to eliminate the cardiovascular effect. The central effect of ouabain caused a... | 4,981 | [
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Biliary secretion in elasmobranchs. I. Bile collection and composition. | Bile composition and secretion were studied in tow elasmobranch species, Squalus acanthias (spiny dogfish shark) and Raja erinacea (small skate), after ligation of the common duct and insertion of cannulas into the gallbladder lumen. Fish were then allowed to swim freely in large pools and bile was collected in balloon... | 4,983 | [
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[The influence of PaCO2 on oxygen consumption during extracorporeal circulation in hypothermia (author's transl)]. | Hypocapnia during extracorporeal circulation in hypothermia increases oxygen consumption. Po2 in mixed venous blood decreases. This probably reflects a decrease in tissue oxygen tension. Hyperventilation will therefore increase the risk of hypoxia in critically perfused tissues. Therefore we recommend to keep PaCO2 (T)... | 4,989 | [
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[Accidental peroperative hypothermia during rapid transfusion]. | Six cases of grave hypothermias are reported, having arisen during surgical interventions which necessitated a rapid and abundant transfusion of badly warmed blood. The role of favouring factors, surrounding cold due to the air-conditioning, anaesthesia, extent of the area of operation, seems important. The symptomatol... | 5,005 | [
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[Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves]. | ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interactions between this product and certain drugs used in anesthesia from the cardiovascular point of view. ISKEDYL does not seem to be a contrai... | 5,007 | [
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[Postoperative circulatory arrest (apropos of 37 cases)]. | Within five years, the authors received 37 patients who had presented a post-operative cardiac arrest. Most of them came from the Bordeaux district (from the hospital as well as the public sector) although they did not represent the totality of such accidents. The study bears first of all upon the data concerning the p... | 5,017 | [
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[Comparative study of nitrogen savings during enteral and parenteral feeding (Trive 1000)]. | Through a study of Nitrogen balances, the authors compare the effectiveness of a proteinic intake carried out per os or by intravenous route. The study involved 22 different carcinoma carriers and lasted for 9 days during which the Nitrogen intake was effected either by the digestive tract or by intravenous route suppl... | 5,021 | [
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[The use of dopamine during postoperative cardiogenic shock in children. Preliminary results]. | Dopamine was used in a dose of 5 mug/kg/min in ten infants with congenital cardiopathy and presenting in the immediate postoperative period a syndrome of low cardiac output. The output was not measured but, based on the evolution of the clinical signs, six favourable results, with correction of the syndrome, can be rep... | 5,030 | [
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Susceptibility of pneumococci and Haemophilus influenzae to antibacterial agents. | Strains of Diplococcus pneumoniae and Haemophilus influenzae were tested for susceptibility to numerous antibiotics by a twofold agar dilution method using an inocula replicator. Undiluted, fully grown broth cultures were used as inocula for both species, and cultures of pneumococci diluted 1:1,000 were also tested. Th... | 5,052 | [
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Acute toxicity of selenium dioxide to freshwater fishes. | Acute toxicity tests of selenium dioxide were conducted for 96 to 336 hr in intermittent-flow bioassay systems using six species of freshwater fish. The decreasing order of species sensitivity was: fathead minnow, flagfish, brook trout, channel catfish, goldfish, and bluegil. Curves relating median lethal concentration... | 5,060 | [
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Effect of alpha and beta adrenergic blockade on epinephrine induced pulmonary insufficiency. | Recent studies demonstrated that epinephrine causes significant pulmonary A-V shunting. This study reports the effect of alpha and beta adrenergic blockade on this shunting. Sixty-three anesthetized mongrel dogs were ventilated with a mechanical respirator. Measurements of (1) the pulmonary shunt, (2) cardiac output, (... | 5,061 | [
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0.1053237,
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0.04404627,
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0.2821237,
0.06089895,
0.1436698,
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0.07341909,
-0.07877743,
... |
Mechanistic studies of glutamine synthetase from Escherichia coli: kinetics of ADP and orthophosphate binding to the unadenylylated enzyme. | The kinetics of protein fluorescence change exhibited by ADP or orthophosphate addition to the Mg2+-or Mn2+-activated unadenylylated glutamine synthetase from Escherichia coli were studied. The kinetic patterns of these reactions are incompatible with a simple bimolecular binding process and a mechanism which required ... | 5,113 | [
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... |
Isolation and partial characterization of a protease from Agave americana variegata. | A new protease was isolated from an extract of leaves of Agave americana variegata. The protease (EC 3.4.-) was purified 565-fold with a yield of 39.5%. The 43.8 mg enzyme had a specific activity of 0.44 units/mg. According to electrophoretic, ultracentrifugal and other physical characterizations the enzyme was homogen... | 5,146 | [
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... |
Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases. | Four cultured mammalian cell lines, differing in intrinsic resistance to methotrexate over a 70-fold range, have been compared with respect to several biochemical factors that might influence response to the drug. Cellular activity of the enzymes dihydrofolate reductase and thymidylate synthetase and the total levels o... | 5,189 | [
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0... |
Binding of radioactivity from (14C)thiourea to rat lung protein. | Binding of radioactivity from [14C]thiourea (TU) to rat lung protein was found to occur in vitro. Two binding sites are present. One possesses low affinity/high capacity while the other is characterized by high affinity/low capacity. In vitro binding of [14C]TU to lung protein can be antagonized by the presence of eith... | 5,255 | [
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Oxisuran metabolism in pigs. | The fate of oxisuran in the pig was studied with 14C-labeled drug to quantify its biotransformation and disposition. Despite interanimal differences, it was clear that the compound absorbed rapidly and biotransformed extensively to metabolites which were excreted principally in urine rather than in feces. Direct attack... | 5,259 | [
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... |
Differential dependence on NADPH concentrations of two microsomal corticosteroid 21-hydroxylation reactions. | The dependency on NADPH concentrations of the bovine adrenal cortex microsomal 21-hydroxylation of progesterone and of 17-hydroxyprogesterone was investigated. The average Km for NADPH in the 21-hydroxylation of progesterone is 10.4 muM while that for the 21-hydroxylation of 17-hydroxyprogesterone is 0.6 muM. The optim... | 5,267 | [
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0.01394533,... |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IX. The formation of a 455-nm metabolite-cytochrome P-450 complex. | The reconstituted liver microsomal hydroxylation system was used to study the formation of a metabolite-cytochrome P-450 complex absorbing maximally at 455 nm, with benzphetamine and N-hydroxyamphetamine as substrates. Complex formation required the presence of NADPH, substrate, NADPH-cytochrome c reductase, lipid, and... | 5,265 | [
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0.25... |
Isolation, purification and properties of aortic elastase. | An elastase from pig aorta has been partially purified and characterised; it exhibits immunological cross reaction with pig pancreatic elastase. Its proteolytic (k-elastin gel and polymeric elastin substrates) and esterolytic (N-succinoyl-trialanine paranitroanilide) activities as well as its degree of inhibition by se... | 5,303 | [
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0.08077363,
-0.027514... |
Oral lesions caused by habits. | Oral lesions caused by habits can be of teeth only, of teeth and the soft tissues of the mouth or may be only of the soft tissues. Lesions of teeth are permanent and may remain even when there has been total destruction of soft tissues. Recognition of lesions due to habits such as betel chewing, snuff dipping, pipe smo... | 5,345 | [
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-0.... |
Partial purification and properties of Enterobacter cloacae heat-stable enterotoxin. | Cell free preparations of the whole-cell lysate and ultrafiltration (UF) fractions of broth cultures of a strain of Enterobacter cloacae, isolated from a Puerto Rican with tropical sprue, were assayed for their ability to induce in vivo net water secretion in the rat jejunum. The whole-cell lysate and UM-10 retentate o... | 5,376 | [
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... |
Further studies of the physical and metabolic properties of foot-and-mouth disease virus temperature-sensitive mutants. | Three temperature-sensitive (ts) mutants of foot-and-mouth disease virus were classified as ribonucleic acid negative and as belonging to the same complementation group when measured by virus yields and [3H] uridine incorporation in paired, mixed infections at the nonpermissive temperature (38.5C). Mutant ts-22, the on... | 5,377 | [
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Luminescence and respiratory activities of Photobacterium phosphoreum. Competition for cellular reducing power. | Changes in the in vivo luminescence, respiratory activities, contents of cytochromes, extractable luciferase and NAD(P)H-FMN reductase during growth of the wild (bright) strain of Photobacterium phosphoreum and its dim mutant were determined. The intensity of the in vivo luminescence per cell increased 10 times in the ... | 5,397 | [
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... |
Purification and properties of two ribonucleases in different intracellular compartments in pea root tissue. | Two RNases in bound forms associated with the microsomal membrane and with the ribosomes or unknown particles in pea root tissue were solubilized by subjecting the membrane to sonic oscillation in the presence of EDTA and KC1 and by treating the particles with EDTA, respectively. The RNases were than purified by DEAE-c... | 5,408 | [
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... |
Purification and properties of an exo-cellulase component of novel type from Trichoderma miride. | An enzyme extract from Cellulase-Onozuka, a commercial product of Trichoderma viride, was fractionated by Amberlite CG-50 column chromatography into three cellulase [EC 3.2.1.4] groups, peaks I to III. A noval enzyme, which has both beta-glucosidase [EC 3.2.1.21] and exo-carboxymethyl-cellulase (exo-CMCase) properties ... | 5,409 | [
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0... |
Titration study of acetylated lysozyme. | To study the interaction between carboxyl groups and amino groups in native lysozyme [EC 3.2.1.17], and to identify the positions and the pK values of the abnormal carboxyl groups, N-acetylated lysozyme was prepared. The acetylation did not affect the molecular shape of the enzyme, but changed six amino groups to a non... | 5,421 | [
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0.04740255,
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Isolation of a low molecular weight active fragment of potato proteinase inhibitor IIb. | A low molecular weight active fragment of potato proteinase inhibitor IIPB was obtained by incubating the inhibitor with an equimolar amount of trypsin [EC 3.4.21.4] at pH 8 and 30 degrees for 16 hr, followed by gel filtration through Sephadex G-50, treatment with trichloroacetic acid, and CM-cellulose chromatography. ... | 5,422 | [
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0.03... |
Regulation of steady state level of phosphoenzyme and ATP synthesis in sarcoplasmic reticulum vesicles during reversal of the Ca2+ pump. | The role of the Ca2+ concentration gradient in ATP synthesis and membrane phosphorylation by Pi was investigated in sarcoplasmic reticulum vesicles isolated from rabbit skeletal muscle. The Pi concentration required to attain 50% of the maximal membrane phosphorylation varies significantly in the pH range of 5.5 to 4.5... | 5,437 | [
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Studies on tyrosine residues in porcine muscle adenylate kinase. Circular dichroism spectra and chemical modification with tetranitromethane. | Substrate-induced conformational change of porcine muscle adenylate kinase (EC 2.7.4.3) is evidenced by a change in circular dichroism spectra in the near ultraviolet. In the absence of tryptophan in porcine muscle adenylate kinase, the spectral change may be assigned to a perturbation of tyrosine chromophore(s). The s... | 5,449 | [
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... |
Association of gylcogenolysis with cardiac sarcoplasmic reticulum. | Sarcoplasmic reticulum fragments isolated from dog cardiac muscle possess a calcium-accumulating system associated with a series of enzymes linked to glycogenolysis. These enzymes include: adenylate cyclase, cyclic AMP-dependent protein kinase, phosphorylase b kinase, phosphorylase (b/a, 30/1),"debrancher" enzyme, and ... | 5,455 | [
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0.4013488,
-0.04659... |
A reversed-phase thin-layer chromotographic method for the determination of relative partition coefficients of very lipophilic compounds. | A reversed-phase thin-layer chromatographic method has been developed for the determination of partition coefficients. A support phase has been chosen, following investigation of the lack of adsorptive properties, which has a minimal effect on the pH of the buffer system. A stationary phase has been chosen to give delt... | 5,460 | [
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Purification of canine prolactin by preparative isotachophoresis. | Preparative isotachophoresis in polyacrylamide gel using carrier ampholytes as 'spacers' has been used to purify prolactin from canine pituitary extracts. Using Ampholine pH 5-8 as spacers, a prolactin fraction was obtained which was essentially homogeneous as judged by the criteria of disc electrophoresis and isoelect... | 5,569 | [
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-0.19021... |
Mannosidosis: phenotype of a severely affected child and characterization of alpha-mannosidase activity in cultured fibroblasts from the patient and his parents. | A three-year-old boy has coarse facial features, upper respiratory congestion, profound mental retardation, hepatosplenomegaly, increased height and head circumference, cataracts, a gibbus deformity, radiographic changes of dysostosis multiplex, and vacuolized peripheral lymphocytes. These findings are the most commonl... | 5,584 | [
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0.4259831,
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Rapid GLC determination of fusaric acid in biological fluids. | A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatogra... | 5,590 | [
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0.07325421,
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-0.26... |
Conformational populations for antihistamines and antihypertensives in solution. | The conformations in aqueous solution were determined for the XCH2CH2N systems of some antihistamines (H1-receptor antagonists) and some adrenergic neuron blocking agents, including the antihypertensive drugs guanethidine and guanoclor. The rotameric species thought to be the pharmacologically active one is often not t... | 5,591 | [
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0.1324019,
0.000135445... |
Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction. | The effects of the compounds 2-, 3- and 4-aminopyridine and sparteine on membrane conductance changes were examined using both voltage-clamped Myxicola axons and the lobster neuromuscular junction. In Myxicola axons, the aminopyridines very specifically inhibited the potassium conductance when applied at concentrations... | 5,600 | [
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0.005070317,
0.4072959,
-0.08920842,
0.1508084... |
Changes in contractility and calcium binding of guinea pig taenia coli by treatment with enzymes which hydrolyze sialic acid. | The effects of neuraminidase and phospholipase C on the contractility and the Ca++ -binding of guinea pig taenia coli were investigated. Potassium contracture or histamine-induced contracture of taenia coli was inhibited by treatment with neuraminidase, though acetylcholine-induced contracture was not. Treatment with p... | 5,622 | [
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The effects of nalorphine and naloxone on maternal and fetal blood gas and pH. | In the control trials on near-term pregnant women before the onset of labour, nalorphine was found to cause a mild respiratory acidosis in the mother and metabolic acidosis in the fetus. These effects were not apparent when naloxone was administered. | 5,649 | [
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0.247323,
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[Investigations of the lipase activity of a pancreatin compound (author's transl)]. | In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excretory function. Digestive potency is regarded as a suitable gauge for comparing of re... | 5,651 | [
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[Interaction between proteins and acid polysaccharides]. | The intereaction between proteins and acid polysaccharides is electrostatic in nature and leads to the formation of soluble charged and insoluble neutral complexes. The complex formation in the system casein-dextran sulphate is followed by means of turbidimetric titration. It depends on the pH value and the electrolyte... | 5,677 | [
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[Mass transfer in production of milk protein coprecipitates]. | During the last twenty years heat coagulation has become a more important technical procedure for the isolation of milk proteins because of its very efficient utilization of raw material. Experiments are reported to get approximation equations for the mass transfer in the production of milk protein coprecipitates from ... | 5,680 | [
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Oxygen transport in congenital heart disease: influence of fetal hemoglobin, red cell pH, and 2,3-diphosphoglycerate. | In 48 individuals (age 1 day to 13 years) with congenital heart disease, blood oxygen transport function was studied in order to evaluate adaptive changes in shunt hypoxemia and to investigate the in vivo regulation of erythrocyte 2, 3-diphosphoglycerate concentration (RBC 2, 3-DPG) in the presence of fetal hemoglobin ... | 5,699 | [
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Effect of excision of the Y-base on the interaction of tRNAPhe (yeast) with phenylalanyl-tRNA synthetase (yeast). | The interaction between tRNAPhe (yeast), from which the Y-base has been removed by acid treatment, and phenylalanyl-tRNA synthetase (yeast) has been investigated by fluorescence competition titrations and sedimentation velocity runs. The binding parameters are given under various ionic conditions. The tRNAPhe-Y still c... | 5,707 | [
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Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. | Incubation of purified frog erythrocyte membranes with beta-adrenergic agonists at 25 degrees produces relatively rapid (half-time about 10 min) desensitization (inactivation) of about 60% of the beta-adrenergic receptor binding sites. The desensitized receptors no longer bind the specific beta-adrenergic ligand (-)[3H... | 5,723 | [
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A comparison of beating parameters in larval and post-larval locomotor systems of the lobster Homarus gammarus (L.). | A study has been made of the interrelations between rhythmical exopodite beating in different larval stages and swimmeret beating in poast-larval stages of the lobster Homarus gammarus. Data on exopodite beat cycle durations have been used for statistical comparisons of exopodite performance within one larva, and also ... | 5,739 | [
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Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate. | Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely affects oxygen release from the red blood cell, thereby leading to myocardial cellular hypoxi... | 5,754 | [
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Muscarinic stimulation of cardiac guanylate cyclase. | Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (db-cAMP) at varying concentrations from 1 X 10(-4) M to 1 X 10(-3) M. A positive inotropic effect was observed with all concentrations of db-cAMP. Concomitant administration of 5 X 10(-4) M monobutyryl guanosine 3',5... | 5,759 | [
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Some properties of rat myocardial ornithine decarboxylase and the in vitro effects of nucleotides. | Myocardial ornithine decarboxylase appears to have characteristics similar to those of enzymes isolated from other tissues. Ornithine decarboxylase activity decreased very rapidly after the death of the animal. Storage of the cell sap fraction at 0 degrees C or -15 degrees C, however, led to only a small decrease in th... | 5,762 | [
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Response to jejunal acidification in man. I. Changes in composition of perfusate. | The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium b... | 5,770 | [
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[Bacteriological examinations of bronchial secretion in children with non-specific bronchopulmonary disease (author's transl)]. | One thousand specimens of bronchial secretion from children with non-specific respiratory diseases have been examined bacteriologically. In spite of the complex nature of acute and especially of chronic respiratory disease the role of bacterial infection should not be underestimated. Thirty per cent of the specimens we... | 5,823 | [
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Some factors influencing the haemolysis of Bordetella bronchiseptica. | Strain-dependent variations in the ability of Bordetella bronchiseptica to produce haemolysis on solid media exist. Haemolysis is strongest at an acid reaction and will not take place if the reaction is too alkaline. Peptone and glutamine inhibit haemolysis and favour growth. The vigorous growth rapidly produced an alk... | 5,844 | [
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Oxygen uptake and tissue oxygen tension during adrenergic stimulation in canine subcutaneous adipose tissue. | The effect of sympathetic nerve stimulation (NS) and injected noradenaline (NA) or isoprenaline (Iso) on PVO2, VO2 and PtO2 was studied in isolated canine subcutaneous adipose tissue. These effects were compared to those produced by mechanical blood flow reduction (clamping). Resting VO2 measured 13.0+/- 2.3 mumol X mi... | 5,850 | [
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Properties of hydroxysteroid oxidoreductase isolated from yeast. | Yeasts can advantageously be utilized for the production of the 17beta-hydroxy-derivative, from 3-methoxy-8,14-seco-1,3,5(10),9(11)-estratetraene-14,17-dione (14,17-dione) while 14alpha-hydroxy and 14alpha,17beta-dihydroxy-derivatives are also formed. The biochemical properties of yeasts' enzymes responsible for the fo... | 5,855 | [
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Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives. | Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) replication. With the exception of deoxyadenosine and cyclic AMP all natural adenine derivatives exerted a synergic effect with A... | 5,863 | [
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Levels of immunoglobulins and antibodies to haemaglutinin and neuraminidase of influenza virus in nasal secretions after natural infection. | Nasal washings (NW) from 16 influenza patients in the course of an epidemic in November and December, 1974 were examined for the presence of influenza virus, immunoglobulins (Ig) and titres of haemagglutination inhibiting (HI) and neuraminidase inhibiting (NI) antibodies. Influenza virus identical with A/Port Chalmers/... | 5,867 | [
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Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys. | Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by benzene. These data thus indicate that renal glomeruli contain the histidine-specifi... | 5,898 | [
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Premedicant drugs and gastric juice pH and volume in pediatric patients. | The effects of premedication on gastric juice volume and pH were evaluated in five groups of 206 pediatric patients undergoing elective surgical procedures: Group 1 (Control) received no premedication; Group 2 was given morphine sulfate and pentobarbital as premedicants. The other groups received, in addition to morphi... | 5,924 | [
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Arterial hypoxemia caused by intravenous ketamine. | Ketamine given IV in a dose of 2 mg/kg caused a significant reduction in Pao2 in 7 patients spontaneously breathing with an unassisted airway. Under the same conditions, in 7 patients, ketamine (2 mg/kg IV) preceded by diazepam (0.2 mg/kg IV) also caused a reduction in Pao2 not significantly different from that caused ... | 5,920 | [
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Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). | Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and lid reflexes, remained active. Systolic, diastolic, and pulse pressure were slightly increased, with as... | 5,921 | [
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[Study of the penicillin amidase from E. coli. An ultrasonic method of studying the ph- and temperature-conformational transitions in the active center of the enzyme]. | pH and temperature conformation transitions in the active center of penicillin amidase i.e. penicillinamidohydrolase E.C. 3.5.I.II were investigated by means of the kinetic method and a new ultrasonic method. It was shown that the catalytic activity of the enzyme was controlled by 2 ionogenic groups with pK 6.1 and 10.... | 5,943 | [
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Nitrogen fixation by hydrogen-utilizing bacteria. | Seventeen strains of nitrogen-fixing bacteria, isolated from different habitats on hydrogen and carbon dioxide as well as on other substrates, morphologically resembled each other. All strains, including Mycobacterium flavum 301, grew autotrophically with hydrogen. The isolate strain 6 was sensitive to oxygen when depe... | 5,978 | [
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0.5624816,
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Glycogenolysis in the heart and skeletal muscle during stimulation and blocking of cholinergic receptors. III. Action of acetylcholine under conditions of sympathicolysis. | Changes in enzymatic activities in phosphorolytic and hydrolytic glycogenolysis in the working heart and in resting skeletal muscle after intravenous injection of sympathicolytic compounds were studied in vitro. Reserpine, alderline and ligation of the adrenals inhibited the influence of acetylcholine on phosphorylase,... | 5,985 | [
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Biomedical aspects of oxygen regulator performance: I. Static characteristics. | Static performance characteristics of current-inventory USAF oxygen regulators were evaluated with the use of a specialized regulator test stand. Outlet suction pressures, flows, positive pressures, and delivered oxygen dilutions were monitored and recorded as functions of operational altitudes. General findings indica... | 5,993 | [
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Gamma-glutamyltransferase of rat kidney. Simultaneous assay of the hydrolysis and transfer reactions with (glutamate-14C)glutathione. | 1. The hydrolytic and transfer reactions catalysed by rat kidney-gamma-glutamyltransferase (EC 2.3.2.2) were studied in vitro with substrates [U-14C]glutamic acid-labelled glutathione and methionine. Initial-velocity patterns, isotope-exchange and binding studies were consistent with a branched non-sequential mechanism... | 6,004 | [
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Light-induced membrane potential and pH gradient in Halobacterium halobium envelope vesicles. | Illumination of envelope vesicles prepared from Halobacterium halobium cells causes translocation of protons from inside to outside, due to the light-induced cycling of bacteriorhodopsin. This process results in a pH gradient across the membranes, an electrical potential, and the movements of K+ and Na+. The electrical... | 6,040 | [
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... |
[Immobilized phospholipase D]. | Conditions of phospholipase D adsorption on silica gels have been studied. The immobilized phospholipase D is shown to differ from the soluble form in thermostability, pH optima and activation conditions. A question is discussed as to the connection of the use of activators and the adsorption immobilization. It is assu... | 6,081 | [
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0.1983742,
-0... |
Regulation of acetyl-CoA synthetase of Saccharomyces cerevisiae. | Acetyl-coenzyme A synthetase (EC 6.2.1.1) activity of Saccharomyces cerevisiae was determined by a radioactive assay procedure. The activity in vitro was inhibited significantly by NADPH, NADH, or AMP and to a lesser extent by NADP, NAD, or ADP. Glutamic acid and alpha-ketoglutaric acid were not inhibitory. The enzyme ... | 6,141 | [
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0.07868285,
0.5956525,
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0.1778772,
0.1... |
Transient inhibition of cell proliferation in rat glioma monolayer cultures by cortisol. | The effect of 3 muM cortisol on cell proliferation in rat glioma (strain C6) monolayer cultures was investigated. Cell density measurements showed that cortisol-treated C6 cells continued to proliferate at maximum log phase rates for 1 to 2 days. Then cell proliferation ceased as growth in control cultures continued in... | 6,144 | [
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0.03595632,
0.4854187,
0.3332913,
0.04360957,
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... |
Diazepam abuse: incidence, rapid screening, and confirming methods. | We studied 2500 patients suspected to be drug-overdose victims. Blood samples were quantitatively screened for the most commonly abused drugs, including diazepam. Of these, 61% had positive findings, including diazepam in about one of every four. A new rapid, simple, and quantitative gas-chromatographic method for simu... | 6,164 | [
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0.... |
Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. | I studied the kinetics and sensitivity toward inhibition by levamisole and R 8231 of the most important human alkaline phosphatase isoenzymes. N-Ethylaminoethanol proved superior to the now widely used diethanolamine buffer, especially for the enzymes from the intestine and placenta, behaving as an uncompetitive activa... | 6,169 | [
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0.09025253,
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Determination of erythrocyte folate by competitive protein binding assay preceded by extraction. | Determination of the concentration of erythrocyte folate by means of competitive protein binding assay critically depends on the extraction procedure applied. Results will be influenced by variable factors such as the in vitro age of the blood samples, the degree of hemolysis, the presence of ascorbic acid, and the pH ... | 6,170 | [
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0.476188,
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0.3311569,
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0.... |
Central nervous system salicylate. | The poor correlation between clinical salicylate toxicity and serum blood levels is reapproached in light of recent evidence linking clinical severity with initial volume of distribution (Vd). It is recognized that two variables alter salicylate Vd in such manner that serum salicylate levels are misleading (thus, the c... | 6,188 | [
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0.1742122,
0.3484318,
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0.135696,
-0.008068311,
... |
Mirex kinetics in the rhesus monkey. II. Pharmacokinetic model. | 14C-Mirex was given iv and po to female rhesus monkeys (Macaca mulatta) and radioactivity was measured in plasma, urine, and feces at intervals after dosing and in tissues when animals were killed. Graphical analysis of plots of the logarithm of plasma concentration vs. time was used to provide estimates of the values ... | 6,235 | [
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0.2550772,
0.5319793,
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-0.01... |
Some aspects of the pharmacology of beta-adrenorecptor blockers. | The pharmacodynamic properties of a beta-blocker are mainly determined by its affinity to beta1 and beta2-receptors respectively and by its intrinsic activity. It is suggested that there is no absolute organ separation of the two receptor sub-types. Instead both beta1 and beta2-receptors are involved in the mediation o... | 6,242 | [
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0.04771751,
0.02992302,
0.1997144,
0.2565929,
0.1978487,
0.0662441,
... |
Experience with beta-adrenoreceptor blockers in hypertension. | At the Dunedin Hypertension Clinic beta-blockers are the drugs of choice for most hypertensive patients, usually in combination with diuretics (especially in older subjects) and often with other drugs in the more severe cases. All beta-blockers have an antihypertensive effect, regardless of other characteristics (e.g. ... | 6,249 | [
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0.1833455,
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0.3095538,
0.2390044,
0.1032986,
0.03697689,
... |
Uptake of bromosulfophthalein by isolated liver cells. | Uptake of the hepatodiagnostic dye bromosulfophthalein into isolated hepatocytes was studied with special regard to the kinetics of transport. The following results were obtained. 1. The uptake of bromosulfophthalein follows Michaelis-Menten kinetics only at low substrate concentrations with an apparent Km=7 +/- 2 muM ... | 6,268 | [
-0.3330978,
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0.2401785,
0.1589349,
0.03472363,
-0.... |
Purification and properties of D-glyceraldehyde-3-phosphate dehydrogenase from an extreme thermophile, Thermus thermophilus strain HB 8. | 1. D-Glyceraldehyde-3-phosphate dehydrogenase from an extreme thermophile, T. thermophilus strain HB8, was purified and crystallized. 2. The enzyme was found to possess remarkable heat stability, being slowly inactivated at 90 degrees C. 3. Basic kinetic constants and pH profile are reported. The enzyme was activated 2... | 6,270 | [
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0.07267068,
0.2736861,
0.3009304,
-0.0951186,
0.23... |
Some adrenergic beta-blocking agents affecting lipolysis in human adipose tissue in vitro. | Antagonistic actions of beta-blocking drugs on isoproterenol-induced lipolysis were studied in human omental adipose tissue. Competitive interaciton characterized by the following pA2 values was found: propranolol 8.7; trimepranol 8.7; practolol 7.1; H 35/25 6.0. The plot of pA2 values of these drugs for human versus r... | 6,293 | [
0.06556997,
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0.09031636,
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0.248158,
0.03257019,
0.2548415,
-0.0536018,
... |
Role of fat maldigestion in pathogenesis of steatorrhea in ileal resection. Fat digestion after two sequential test meals with and without cholestyramine. | To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 p... | 6,360 | [
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-0.3061339,
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0.2874303,
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-0.03041168,
0.1430429,
0.2438385,
0.1105334,... |
Kinetic studies of the alkaline mesentericopeptidase. Study on the active centre topography of alkaline mesentericopeptidase by means of bifunctional reversible inhibition. | The inhibitory effect of alkylboronic acids H(CH2)nB(OH)2(n=2-8) and Ph(CH2)n-B(OH)2, (n=0-4), on the alkaline mesentericopeptidase-catalysed hydrolysis of synthetic substrates was studied. It was shown that alkylboronic acids act as bifunctional reversible inhibitors. The borate group interacts with an ionogenic group... | 6,394 | [
-0.1355943,
-0.157543,
-0.1884049,
-0.1203341,
0.1578353,
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0.1528416,
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0.242341,
0.3396764,
0.1700581,
-0.2024315,
0... |
pH-dependent temperature sensitivity of rat lens phosphofructokinase. | Rat lens phosphofructokinase (PFK) has been found to be cold-labile at acidic pH, even in the presence of sulfate and inorganic phosphate, two known positive effectors. The inactivation appears to be an irreversible process, but can be prevented by including ATP in the incubating media. The enzyme is relatively stable ... | 6,404 | [
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0.03097306,
0.1796512,
0.2951677,
0.1900751,
-0.07395998... |
The fetal renin-angiotensin system in normal and hypertensive pregnancy. | Plasma angiotensin II was measured in the umbilical cord arterial and/or venous blood of 54 babies delivered vaginally and in 12 delivered by elective lower segment cesarean section. Angiotensin II was also measured in the peripheral venous blood of 51 of the mothers. Mean angiotensin II levels at delivery were higher ... | 6,405 | [
0.09724082,
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0.1782752,
0.08273219,
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0... |
Role of polyadenylic acid in a deoxyribonucleic acid-membrane fraction extracted from pneumococci. | After the addition of radioactive polyadenylic acid to cell suspensions of pneumocci, part of the radioactivity becomes associated with a deoxyribonucleic acid (DNA)-membrane fraction extracted from the cells. A variety of techniques show that a portion of this associated radioactivity may represent oligoadenylates com... | 6,428 | [
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0.2346871,
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0.1025294,
0.5120595,
0.7645481,
0.01844731,
-0.1945457,
... |
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