title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Use of healthcare services in the residence and workplace neighbourhood: the effect of spatial accessibility to healthcare services. | This study investigated the effect of spatial accessibility to healthcare services (HS) in residential and workplace neighbourhoods on the use of HS. Questionnaire data from the RECORD Study (2007-2008) were merged with administrative healthcare and geographic data. A novel method was developed to assess clustering of ... | 25,262,490 | [
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Lacosamide efficacy in epileptic syndromes with continuous spike and waves during slow sleep (CSWS). | Epileptic syndromes with continuous spikes-waves during sleep (CSWS) represent a wide spectrum of epileptic disorders having CSWS as a common EEG-feature. Defined therapeutic strategies are still lacking. We evaluated the efficacy of lacosamide add-on therapy on the EEG, behavior, and cognition in children with CSWS. E... | 25,262,499 | [
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Research for the influence of telomerase inhibitors on myeloma cell and therapy. | This paper aims to study the effect of telomerase inhibitors zidovudine (AZT) on cell morphology,survival rate and telomerase activity of in-vitro culture myeloma cell line (U266).It has provided experiment basis for applying telomerase inhibitors in multiple myeloma treatment. The myeloma cell line in logarithmic phas... | 25,262,511 | [
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Curative effect research on curing intercostal neuralgia through paravertebral nerve block combined with pregabalin. | This paper aimed to discuss the curative effect and safety of curing intercostal neuralgia through paravertebral nerve block combined with pregabalin. 90 cases of patients diagnosed as intercostal neuralgia were taken as research object. Random number method was used to divide the patients that is conforming to the inc... | 25,262,512 | [
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Simultaneous analysis of cocaine and its metabolites in rat liver microsome s9 fraction by liquid chromatography-mass spectrometry. | A method utilizing liquid chromatography-mass spectrometry for the simultaneous analysis of cocaine and its in-vitro metabolites in rat liver micro some S9 fraction is described. Cocaine was incubated with rat liver micro some S9 fraction firstly, and then the incubation sample mixture was analyzed by liquid chromatogr... | 25,262,520 | [
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Research on recovery function of two drugs combination on rat sciatic nerve injury regeneration model. | This paper aims to study the recovery function of two drugs combination on rat sciatic nerve injury regeneration model. Sixty rats were divided into groups randomly and averagely. All animals after dividing left sciatic nerve were given epineurium-interrupted suture for constructing peripheral nerve injury model. Muscl... | 25,262,521 | [
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Long-term cannabis abuse and early-onset cannabis use increase the severity of cocaine withdrawal during detoxification and rehospitalization rates due to cocaine dependence. | Long-term and early-onset cannabis consumption are implicated in subsequent substance- related problems. The aim of this follow-up study was to investigate whether these patterns of cannabis use could impact cocaine withdrawal severity and cocaine craving intensity during detoxification. In addition, we investigated th... | 25,262,527 | [
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Doppler-guided ligation of hemorrhoidal arteries with mucopexy: A technique for the future. | The transanal hemorrhoidal de-arterialization (THD) procedure is an effective treatment of hemorrhoidal disease. The ligation of hemorrhoidal arteries ("de-arterialization") can provide a significant reduction of arterial blood flow to the hemorrhoidal tissues. Plication of redundant rectal mucosa/submucosa ("mucopexy"... | 25,262,549 | [
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Comparison of toxicities of moxifloxacin, cefuroxime, and levofloxacin to corneal endothelial cells in vitro. | To evaluate and compare the toxic effects of moxifloxacin, cefuroxime, and levofloxacin on human corneal endothelial cells in vitro and determine the safe intracameral concentrations for them. Tottori University, Tottori, Japan. Experimental study. Human corneal endothelial cells in culture were exposed to moxifloxacin... | 25,262,563 | [
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Normosmic idiopathic hypogonadotropic hypogonadism due to a novel homozygous nonsense c.C969A (p.Y323X) mutation in the KISS1R gene in three unrelated families. | The spectrum of genetic alterations in cases of hypogonadotropic hypogonadism continue to expand. However, KISS1R mutations remain rare. The aim of this study was to understand the molecular basis of normosmic idiopathic hypogonadotropic hypogonadism. Clinical characteristics, hormonal studies and genetic analyses of s... | 25,262,569 | [
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Associations between erythrocyte membrane fatty acid compositions and insulin resistance in obese adolescents. | Cytokines released from the adipose tissue and fatty acids (FAs) derived from lipolysis or uptake of fats go in to competition with glucose to be uptaken from the liver leads to insulin resistance (IR). We aimed to show the associations among serum lipid profile, FA compositions and IR. Anthropometrical measurements, b... | 25,262,585 | [
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Insular infarct size but not levosimendan influenced myocardial injury triggered by cerebral ischemia in rats. | Cerebral injuries can trigger stress-related cardiomyopathy. The extent of cerebral injury and the involvement of the insular cortex influence the incidence and extent of myocardial injury (MI), and drugs with proven neuroprotective and cardioprotective properties such as levosimendan might be beneficial. This hypothes... | 25,262,586 | [
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Acute effect of Snus on physical performance and perceived cognitive load on amateur footballers. | Smokeless tobacco (Snus) is a substance that contains nicotine, which has been placed on World Anti-Doping Agency's 2014 Monitoring Program. A proliferation of nicotine use in sport has been observed in recent years, but little is known regarding its effects, especially on football players' performance. Therefore, the ... | 25,262,592 | [
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A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo. | Cancer is the second leading cause of death by disease in the world. Chemotherapy is one of three major therapeutic methods for cancer treatment, but cancer cells gradually evolve resistance to chemotherapeutic reagents. For centuries, traditional Chinese medicine (TCM) was used to fight against cancer. In recent years... | 25,262,593 | [
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[A comparative study of the laparoscopic appearance and anatomy of the autonomic nervous in normal males]. | To further understand the anatomical basis of pelvic autonomic nerve preservation. Autopsy of five adult male donated cadavers was performed. Meanwhile, ten videos of laparoscopic total mesorectal excision for male mid-low rectal cancer admitted from January to June 2012 were observed and studied. Anatomical features o... | 25,262,605 | [
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Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: applications in secondary structure analyses. | Circular dichroism (CD) spectroscopy is a valuable method for defining canonical secondary structure contents of proteins based on empirically-defined spectroscopic signatures derived from proteins with known three-dimensional structures. Many proteins identified as being "Intrinsically Disordered Proteins" have a sign... | 25,262,612 | [
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Dynamic aspects of spermiogenic chromatin condensation patterning by phase separation during the histone-to-protamine transition in charalean algae and relation to bryophytes. | During early-to-middle spermiogenesis in multicellular, internally fertilizing charalean green algae (Chara fibrosa, Chara vulgaris, Chara tomentosa, Nitella missouriensis), patterning of chromatin/nucleoplasm in developing spermatid nuclei changes from granules → fibers → contorted lamellae → condensed chromatin. Cyto... | 25,262,620 | [
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Structural alterations of brain grey and white matter in early deaf adults. | Functional and structural brain alterations in the absence of the auditory input have been described, but the observed structural brain changes in the deaf are not uniform. Some of the previous researchers focused only on the auditory areas, while others investigated the whole brain or other selected regions of interes... | 25,262,621 | [
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Pore size--a key property for selective toxin removal in blood purification. | Extracorporeal blood purification systems based on combined membrane/adsorption technologies are used in acute liver failure to replace detoxification as well as to remove inflammatory mediators in sepsis patients. In addition to coating and chemical modification of the surface, pore size significantly controls the sel... | 25,262,632 | [
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Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients. | Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings suggest that anhedonia is characterized by reduced reward anticipation and motivation of obtaining reward. However, relatively little is known about reward-based decision-making in depression. We tested the hypothesis that anhedoni... | 25,262,638 | [
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Non-linearity and heterogeneity in modeling of population dynamics. | The study of population growth reveals that the behaviors that follow the power law appear in numerous biological, demographical, ecological, physical and other contexts. Parabolic models appear to be realistic approximations of real-life replicator systems, while hyperbolic models were successfully applied to problems... | 25,262,656 | [
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Prinzmetal angina: ECG changes and clinical considerations: a consensus paper. | We will focus our attention in this article in the ECG changes of classical Prinzmetal angina that occur during occlusive proximal coronary spasm usually in patients with normal or noncritical coronary stenosis. The most important ECG change during a focal proximal coronary spasm is in around 50% of cases the appearanc... | 25,262,663 | [
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[Serum markers in patients with idiopathic pulmonary alveolar proteinosis]. | Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by PAS positive lipoproteinaceous material accumulation in the pulmonary alveoli, of which autoimmune (APAP) or idiopathic type (IPAP) accounts for about 90%. Several serum markers were reported to be valuable in IPAP diagnosis. However, data in ... | 25,262,689 | [
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[Anti-nerve growth factor antibody reduces airway hyperresponsiveness in a mouse model of asthma by down-regulating the level of autophagy in lungs]. | To study the effects of anti-nerve growth factor (NGF) antibody on the level of autophagy in lung tissue antigen presenting cells in a mouse model of asthma. The 24 BALB/c mice aged 6 weeks were divided into control group (PBS sensitization, PBS challenge) , asthma group [ovalbumin (OVA) sensitization, OVA challenge] a... | 25,262,691 | [
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Developing communicative competence: a longitudinal study of the acquisition of mental state terms and indirect requests. | This longitudinal study involving 101 Dutch four- and five-year-olds charts indirect request (IR) and mental state term (MST) understanding and investigates the role that Theory of Mind (ToM) and general linguistic ability (vocabulary, syntax, and spatial language) play in this development. The results showed basic und... | 25,262,752 | [
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Energy Expenditure during Functional Daily Life Performances in Patients with Fibromyalgia. | The objective of this study was to evaluate whether patients with fibromyalgia FM need more oxygen and more time to complete a walking and stair-climbing task than healthy volunteers and perceive the performance of these tasks as more strenuous. Furthermore, it was evaluated whether a less efficient performance is more... | 25,262,764 | [
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Mycobacterial DNA gyrB inhibitors: Ligand based pharmacophore modelling and in vitro enzyme inhibition studies. | Among the topoisomerases, DNA gyrase belongs to the type II classes that catalysing DNA supercoiling or relaxation, catenation or decatenation, knotting or unknotting. It is one of the validated targets for anti-tubercular drug discovery and inhibitors from this group are also active against non-replicating, persistent... | 25,262,795 | [
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Multiple independent IgE epitopes on the highly allergenic grass pollen allergen Phl p 5. | Group 5 allergens are small proteins that consist of two domains. They belong to the most potent respiratory allergens. To determine the binding sites and to study allergic patients' IgE recognition of the group 5 allergen (Phl p 5) from timothy grass pollen using human monoclonal IgE antibodies that have been isolated... | 25,262,820 | [
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0.5514068,
0.005839103... |
Knockdown of tumor protein D52-like 2 induces cell growth inhibition and apoptosis in oral squamous cell carcinoma. | Tumor protein D52-like 2 (TPD52L2) and its family members form homo- and hetero-meric complexes essential for cell proliferation in multiple human cancers. TPD52L2 is involved in cell migration and attachment in oral squamous cell carcinoma (OSCC). To confirm the role of TPD52L2 in OSCC, we employed the lentivirus-deli... | 25,262,828 | [
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Light-responsive smart surface with controllable wettability and excellent stability. | Novel fluorinated gradient copolymer was designed for smart surface with light-responsive controllable wettability and excellent stability. The switchable mechanism and physicochemical characteristics of the as-prepared surface decorated by designed polymeric material were investigated by ultraviolet-visible (UV-vis) s... | 25,262,829 | [
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Primary biliary cirrhosis in the era of liver transplantation. | Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by the presence of antimitochondrial antibodies (AMA) and progressive immune-mediated destruction of biliary ductules, which lead to cirrhosis. Theories of the PBC etiopathogenesis assume that the disease develops secondarily as an imp... | 25,262,831 | [
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Spotted fever group rickettsiae in ixodid ticks in Oromia, Ethiopia. | In Ethiopia, information on the transmission of human zoonotic pathogens through ixodid ticks remains scarce. To address the occurrence and molecular identity of spotted fever group rickettsiae using molecular tools, a total of 767 ixodid ticks belonging to thirteen different species were collected from domestic animal... | 25,262,832 | [
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Radiographic assessment of posterior malleolar ankle fractures. | The anatomy of the posterior tibial malleolus plays an important role in the structure and function of the ankle mortise. With specific respect to ankle fractures, the presence, size, and displacement of posterior malleolar fractures (Volkmann's fracture) helps determine which will be amendable to operative fixation. T... | 25,262,838 | [
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0.06228507,
0.02381528,
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Canadian Heart Rhythm Society and Canadian Association of Radiologists consensus statement on magnetic resonance imaging with cardiac implantable electronic devices. | Magnetic resonance imaging (MRI) has historically been considered contraindicated for individuals with cardiac implantable electronic devices (CIEDs) such as pacemakers and implantable defibrillators. Magnetic resonance scanners produce magnetic fields that can interact negatively with the metallic components of CIEDs.... | 25,262,858 | [
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Ablation of the epicardial substrate in the right ventricular outflow tract in a patient with Brugada syndrome refusing implantable cardioverter defibrillator therapy. | Brugada syndrome is associated with a high risk of sudden cardiac death. Currently, the cornerstone of therapy is implantation of an implantable cardioverter defibrillator (ICD). Recently, a novel approach to preventively ablate the substrate located in the anterior epicardial region of the right ventricular outflow tr... | 25,262,866 | [
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Hemodynamic study of overlapping bare-metal stents intervention to aortic aneurysm. | To investigate the hemodynamic performance of overlapping bare-metal stents intervention treatment to thoracic aortic aneurysms (TAA), three simplified TAA models, representing, no stent, with a single stent and 2 overlapped stents deployed in the aneurismal sac, were studied and compared in terms of flow velocity, wal... | 25,262,876 | [
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Impact of long-term cryopreservation on single umbilical cord blood transplantation outcomes. | Umbilical cord blood (UCB) may be collected and cryopreserved for years before use. In vitro and murine models suggest that the duration of storage does not affect UCB progenitor cell performance; however, the impact of UCB age on clinical outcomes has not been definitely defined. This study sought to determine the eff... | 25,262,882 | [
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A single surgeon's experience and surgical outcomes of 300 robotic thyroid surgeries using a bilateral axillo-breast approach. | We introduce surgical outcomes regarding 300 cases of robotic thyroidectomy using a bilateral axillo-breast approach (BABA). From April 2010 to October 2013, 300 patients who underwent robotic thyroidectomy were analyzed and compared with 300 cases of open total thyroidectomy. Robotic surgery was performed with a snake... | 25,262,911 | [
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Selective targeting of the stress chaperome as a therapeutic strategy. | Normal cellular function is maintained by coordinated proteome machinery that performs a vast array of activities. Helping the proteome in such roles is the chaperome, a network of molecular chaperones and folding enzymes. The stressed cell contains, at any time, a complex mixture of chaperome complexes; a majority per... | 25,262,919 | [
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Characterization of a biopharmaceutical protein and evaluation of its purification process using automated capillary Western blot. | This paper describes the application of an automated size-based capillary Western blot system (Sally instrument) from ProteinSimple, Inc., for biopharmaceutical fusion-Fc protein characterization and evaluation of its purification process. The fusion-Fc protein column purification from an excess of single chain Fc poly... | 25,262,923 | [
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A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures. | A significant challenge when investigating autonomic neuroanatomy is being able to reliably obtain tissue that contains neuronal structures of interest. Currently, histochemical staining for acetylcholinesterase (AChE) remains the most feasible and reliable method to visualize intrinsic nerves and ganglia in whole orga... | 25,262,932 | [
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Optimization-based methodology for the development of wastewater facilities for energy and nutrient recovery. | A paradigm shift is currently underway from an attitude that considers wastewater streams as a waste to be treated, to a proactive interest in recovering materials and energy from these streams. This paper is concerned with the development and application of a systematic, model-based methodology for the development of ... | 25,262,948 | [
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Comparison of two surgical techniques for resection of uncomplicated sigmoid volvulus: laparoscopy or open surgical approach? | The optimal treatment for acute sigmoid volvulus has not been defined. Our aim was to compare the results of two techniques for the management of uncomplicated sigmoid volvulus coming from two separate surgical services, which had each chosen a different technique: open surgical versus laparoscopic. Patients with sigmo... | 25,262,965 | [
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The Clp protease system is required for copper ion-dependent turnover of the PAA2/HMA8 copper transporter in chloroplasts. | The distribution of essential metal ions over subcellular compartments for use as cofactors requires control of membrane transporters. PAA2/HMA8 is a copper-transporting P1B -type ATPase in the thylakoid membrane, required for the maturation of plastocyanin. When copper is highly available to the plant this transporter... | 25,262,970 | [
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Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics? | Balanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive risk of these carriers varies, they generally have a lower chance to produce normal or balanced gametes. Preimplantation genetic diagnosis (PGD) is offered to these patients to increase their chances of becoming preg... | 25,262,973 | [
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Improving the safety of blood transfusion by using a combination of two screening assays for hepatitis C virus. | To illustrate that the combination of a single nucleic acid amplification test (NAT) with a single immunoassay for hepatitis C virus (HCV) detection, as proposed internationally, may lead to the omission of anti-HCV reactive sera with non-reactive NAT results. In total, 822 of 519, 299 serum samples from 11 blood centr... | 25,262,976 | [
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Polybivalency and disordered proteins in ordering macromolecular assemblies. | Intrinsically disordered proteins (IDPs) are prevalent in macromolecular assemblies and are thought to mediate protein recognition in complex regulatory processes and signaling pathways. The formation of a polybivalent scaffold is a key process by which IDPs drive early steps in macromolecular assemblies. Three intrins... | 25,263,009 | [
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The ever-evolving role of mTOR in translation. | Control of translation allows for the production of stoichiometric levels of each protein in the cell. Attaining such a level of fine-tuned regulation of protein production requires the coordinated temporal and spatial control of numerous cellular signalling cascades impinging on the various components of the translati... | 25,263,010 | [
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Presenting symptoms of glioma in adults. | Studies on the presenting symptoms of glioma in adults in the age of readily available MRI imaging are scarce. This study investigates presenting symptoms of glioma and assesses the correlations of the presenting symptoms with patient age and histopathological class of the tumor. A retrospective review of the medical r... | 25,263,022 | [
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Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. | Depression is a disease that is particularly frequent, affecting up to 20% of the population in Western countries. The origins of this pathology involve multiple genes as well as environmental and developmental factors leading to a disorder that remains difficult to treat. Several therapies for depression have been dev... | 25,263,033 | [
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Prognostic value of enzymatic liver function for the estimation of short-term survival of liver transplant candidates: a prospective study with the LiMAx test. | LiMAx has been recently proposed as a new quantitative liver function test. Thus, we aimed to evaluate the diagnostic ability of LiMAx to assess short-term survival in liver transplant candidates and compare its performance to the model for end-stage liver disease (MELD) and indocyanine green plasma disappearance rate ... | 25,263,095 | [
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Amino-functionalized mesoporous silica modified glassy carbon electrode for ultra-trace copper(II) determination. | This paper described a facile and direct electrochemical method for the determination of ultra-trace Cu(2+) by employing amino-functionalized mesoporous silica (NH2-MCM-41) as enhanced sensing platform. NH2-MCM-41 was prepared by using a post-grafting process and characterized by X-ray diffraction (XRD), transmission e... | 25,263,113 | [
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... |
High angular-resolution automated visible-wavelength scanning angle Raman microscopy. | A scanning angle (SA) Raman microscope with 532-nm excitation is reported for probing chemical content perpendicular to a sample interface. The instrument is fully automated to collect Raman spectra across a range of incident angles from 20.50 to 79.50° with an angular spread of 0.4±0.2° and an angular uncertainty of 0... | 25,263,117 | [
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Do dental esthetics have any influence on finding a job? | Our objective was to determine whether dental esthetics have any influence on finding a new job. Ten patients with orthodontic treatment needs for various types of malocclusions were selected. Smiling facial photographs of all patients were obtained and digitally altered (orthodontic correction of teeth). After the ima... | 25,263,144 | [
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[Carriers of haemophilia: Experience of a French university hospital]. | To report the management of carriers of haemophilia in a French university hospital and assess different issues of these patients. Retrospective study of the carriers of haemophilia who consulted at the university hospital of Montpellier, France, between 1995 and 2011. Information were obtained from medical records and... | 25,263,159 | [
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Genetic and environmental etiologies of the longitudinal relations between prereading skills and reading. | The present study explored the environmental and genetic etiologies of the longitudinal relations between prereading skills and reading and spelling. Twin pairs (n = 489) were assessed before kindergarten (M = 4.9 years), post-first grade (M = 7.4 years), and post-fourth grade (M = 10.4 years). Genetic influences on fi... | 25,263,167 | [
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Colorectal serrated pathway cancers and precursors. | The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from those of the conventional adenoma-carcinoma sequence (APC-pathway). In this review we focus at the outset on the clinical impact, p... | 25,263,173 | [
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A critical analysis of codon optimization in human therapeutics. | Codon optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. Applications for codon optimization include recombinant protein drugs and nucleic acid therapies, including gene therapy, mRNA therapy, and DNA/RNA vaccines. However, recent reports indicate that c... | 25,263,172 | [
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Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice. | A metabolizing enzyme arginase can decrease nitric oxide (NO) production by competing with NO synthase for arginine as a substrate, but its pathophysiological role in heart failure remains unknown. We aimed to investigate the effect of pharmacological inhibition of arginase on left ventricular function in doxorubicin-i... | 25,263,201 | [
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Hierarchical self-assembly of gold nanoparticles into patterned plasmonic nanostructures. | The integration of nanoparticle superstructures into daily life applications faces major challenges including the simplification of the self-assembly process, reduced cost, and scalability. It is, however, often difficult to improve on one aspect without losing on another. We present in this paper a benchtop method tha... | 25,263,238 | [
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Identification of novel homologous series of polyhydroxylated theasinensins and theanaphthoquinones in the SII fraction of black tea thearubigins using ESI/HPLC tandem mass spectrometry. | Thearubigins are the most abundant phenolic pigments found in black tea, produced by enzymatic oxidation of green tea flavan-3-ols in tea fermentation of until recently unknown composition. In this study electrospray ionization tandem LC-MS(n) experiments have been applied for the characterization of crude thearubigins... | 25,263,270 | [
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DNA-based biosensors for Hg(2+) determination by polythymine-methylene blue modified electrodes. | In this work we have developed a new electrochemical DNA-based biosensor for the selective determination of the Hg(2+) ion by the use of different electrodes modified with polythymine, bearing methylene blue, as redox probe, in 3' position. The determination of Hg(2+) can be employed with an excellent degree of selecti... | 25,263,314 | [
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[Shenkang pill down-regulates AOPP-induced expression of inflammatory factor MCP-1 via a p38MAPK/NF-κB-dependent mechanism]. | To investigate the effect of the serum of rats fed with Shenkang pill in regulating monocyte chemoattractant protein 1 (MCP-1) expression induced by advanced oxidation protein products (AOPP) in mouse podocyte clone 5 (MPC5) and explore the underlying mechanism. MPC5 cultured in vitro were incubated for different time ... | 25,263,356 | [
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[Pelvic floor muscle strength screening and analysis of its related factors among migrant women in the Pearl River Delta]. | To investigate the prevalence and related factors of abnormal pelvic floor muscle strength and provide theoretical evidence for the prevention and treatment of pelvic floor dysfunction. A total of 1008 migrant women in hospitals of Guangzhou and Foshan were screened for pelvic floor strength at 42 days postpartum from ... | 25,263,380 | [
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The development of scientific thinking in elementary school: a comprehensive inventory. | The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experim... | 25,263,396 | [
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Sexual and reproductive health for young adults in Colombia: teleconsultation using mobile devices. | Sexual risk behaviors associated with poor information on sexuality have contributed to major public health problems in the area of sexual and reproductive health in teenagers and young adults in Colombia. To report our experience with the use of DoctorChat Mobile to provide sexual education and information among unive... | 25,263,432 | [
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Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. | Tissue inhibitor of metalloproteinases-1 (TIMP-1) recently emerged as a pro-metastatic factor highly associated with poor prognosis in a number of cancers. This correlation seemed paradox as TIMP-1 is best described as an inhibitor of pro-tumourigenic matrix metalloproteinases. Only recently, TIMP-1 has been revealed a... | 25,263,437 | [
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LKB1 reduces ROS-mediated cell damage via activation of p38. | Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutated in Peutz-Jeghers syndrome and in a variety of sporadic cancers. Herein, we demonstrate that LKB1 controls the levels of intracellular reactive oxygen species (ROS) and protects the genome from oxidative damage. Cells l... | 25,263,448 | [
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Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2. | Evasion of cell death is fundamental to the development of cancer and its metastasis. The role of the BCL-2-mediated (intrinsic) apoptotic program in these processes remains poorly understood. Here we have investigated the relevance of the pro-apoptotic protein BIM to breast cancer progression using the MMTV-Polyoma mi... | 25,263,453 | [
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A new class of cancer-associated PTEN mutations defined by membrane translocation defects. | Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling, is a commonly mutated tumor suppressor. The majority of cancer-associated PTEN mutations block its essential PIP3 phosphatase activity. However, there is a group of clinically ident... | 25,263,454 | [
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Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP. | Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. The nuclear receptor small heterodimer partner (SHP) mediates the deleteriou... | 25,263,461 | [
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Selective insulin resistance in hepatocyte senescence. | Insulin resistance has been described in association with chronic liver disease for decades. Hepatocyte senescence has been demonstrated in chronic liver disease and as many as 80% of hepatocytes show a senescent phenotype in advanced liver disease. The aim of this study was to understand the role of hepatocyte senesce... | 25,263,463 | [
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FGF and Notch signaling in sensory neuron formation: a multifactorial approach to understanding signaling pathway hierarchy. | The ophthalmic trigeminal (opV) placode exclusively gives rise to sensory neurons, making it a good model to study the molecular regulation of sensory neurogenesis. A number of signaling pathways including Wnt, PDGF, FGF, and Notch have been shown to be involved in the process of opV placode cell development. However, ... | 25,263,465 | [
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Quantitative phosphoproteomics reveals crosstalk between phosphorylation and O-GlcNAc in the DNA damage response pathway. | The modification of intracellular proteins by monosaccharides of O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential and dynamic PTM of metazoans. The addition and removal of O-GlcNAc is catalyzed by the O-GlcNAc transferase (OGT) and O-GlcNAcase, respectively. One mechanism by which O-GlcNAc is thought to mediat... | 25,263,469 | [
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Pancreatic leakage and acute postoperative pancreatitis after proximal pancreatoduodenectomy. | Acute postoperative pancreatitis (APP) after proximal pancreatoduodenectomy (PDE) is a major and serious complication. The purpose of the the study is early diagnosis of APP, differentiation from pancreatic stump leak and possibilities of surgical treatment. Of all patients who underwent PDE for ductal adenocarcinoma o... | 25,263,473 | [
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NADPH oxidases: an overview from structure to innate immunity-associated pathologies. | Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to cells, and the overproduction of these molecules leads to a myriad of devastating diseases. The key producers of ROS in many cells are... | 25,263,488 | [
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The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin. | To investigate the changes of serum anti-aging protein Klotho and neutrophil gelatinase-associated lipocalin (NGAL) levels and their correlation in type 2 diabetes mellitus (T2DM) patients at different stages of diabetic kidney disease (DKD) determined by urinary albuminuria. 462 cases with T2DM were divided into three... | 25,263,500 | [
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Risk perceptions and trust following the 2010 and 2011 Icelandic volcanic ash crises. | Eruptions at the Icelandic volcanoes of Eyjafjallajökull (2010) and Grimsvötn (2011) produced plumes of ash posing hazards to air traffic over northern Europe. In imposing restrictions on air traffic, regulators needed to balance the dangers of accidents or aircraft damage against the cost and inconvenience to traveler... | 25,263,505 | [
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Serosal abrasion of bowel ends does not enhance anastomotic healing. | Anastomotic leakage rates remain unacceptably high, warranting reconsideration of current anastomotic technique. Anastomotic healing may improve by abrading the serosal surface of bowel ends that are invertedly anastomosed, based on the concept that serosal damage evokes inflammatory adherent processes. It is studied i... | 25,263,509 | [
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Hemodynamic improvement of a LUCAS 2 automated device by addition of an impedance threshold device in a pig model of cardiac arrest. | The combination of the LUCAS 2 (L-CPR) automated CPR device and an impedance threshold device (ITD) has been widely implemented in the clinical field. This animal study tested the hypothesis that the addition of an ITD on L-CPR would enhance cerebral and coronary perfusion pressures. Ten female pigs (39.0 ± 2.0 kg) wer... | 25,263,510 | [
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Human recombinant cementum attachment protein (hrPTPLa/CAP) promotes hydroxyapatite crystal formation in vitro and bone healing in vivo. | Cementum extracellular matrix is similar to other mineralized tissues; however, this unique tissue contains molecules only present in cementum. A cDNA of these molecules, cementum attachment protein (hrPTPLa/CAP) was cloned and expressed in a prokaryotic system. This molecule is an alternative splicing of protein tyros... | 25,263,524 | [
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Changes in maternal blood inflammatory markers as a predictor of chorioamnionitis: a prospective multicenter study. | To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes (PPROM) considering the occurrence of histologically confirmed chorioamnionitis (HCA). A prospective study was conducted in 121 women with PPROM between 24 and 34 + 0 weeks of gestation. Association betwe... | 25,263,526 | [
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... |
High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest. | Cells challenged with DNA damage activate checkpoints to arrest the cell cycle and allow time for repair. Successful repair coupled to subsequent checkpoint inactivation is referred to as recovery. When DNA damage cannot be repaired, a choice between permanent arrest and cycling in the presence of damage (checkpoint ad... | 25,263,563 | [
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0.07305001,
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0.08893377,
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0.1080413,
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0.212765,
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0.3512646,
0.04182686,... |
Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae. | Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported... | 25,263,578 | [
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0.4231133,
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Two-year results of vertebral body stenting for the treatment of traumatic incomplete burst fractures. | Vertebral body stenting (VBS) was developed to prevent loss of reduction after balloon deflation during kyphoplasty. The aim of this study is the radiological and clinical mid-term evaluation of traumatic incomplete burst fractures treated by vertebral body stenting. This retrospective study included patients with trau... | 25,263,584 | [
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Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation. | Connexin 26 (Cx26), a protein involved in gap junctional intercellular communication, has an essential function during organ and tissue development. Its deregulation, in part due to inherent mutations, is associated with pathological conditions including congenital deafness. Regulation of Cx26 protein level is critical... | 25,263,585 | [
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0.2407444,
0.09600956,
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Enhancer RNA facilitates NELF release from immediate early genes. | Enhancer RNAs (eRNAs) are a class of long noncoding RNAs (lncRNA) expressed from active enhancers, whose function and action mechanism are yet to be firmly established. Here we show that eRNAs facilitate the transition of paused RNA polymerase II (RNAPII) into productive elongation by acting as a decoy for the negative... | 25,263,592 | [
0.2127603,
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0.1838596,
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mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues. | MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at steady state in the few contexts examined globally. Here, we extend the global steady-state measurements to additional mammalian contexts and find that regardless ... | 25,263,593 | [
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0.06976119,
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0.0806974,
0.3135122,
0.1744728,
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Can botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniques. | Botulinum toxin type A is a first-line treatment for post-stroke focal spasticity, and the accuracy in delivering the toxin to the target muscles may influence the treatment outcome. Our aim was to compare the reduction of spasticity and the related finger position at rest improvement in post-stroke patients treated wi... | 25,263,601 | [
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0.2725624,
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... |
Sample size allocation for food item radiation monitoring and safety inspection. | The objective of this study is to identify a procedure for determining sample size allocation for food radiation inspections of more than one food item to minimize the potential risk to consumers of internal radiation exposure. We consider a simplified case of food radiation monitoring and safety inspection in which a ... | 25,263,608 | [
-0.1612062,
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0.1601193,
0.06792498,
... |
Development of moyamoya disease in pregnancy and puerperium: case report. | Progressive moyamoya disease in pregnancy and puerperium has not been reported previously. Here, we present a 39-year-old woman who had been found to have moderate stenosis of right middle cerebral artery (MCA) 4 years prior to her pregnancy, finally suffering minor completed stroke due to progressive moyamoya disease ... | 25,263,620 | [
-0.1607726,
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0.3760081,
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-0.100312,
0.352257,
0.2225389,
0.37... |
Patients' Perception of Information and Health-Related Quality of Life 1 Month After Discharge for Colorectal Cancer Surgery. | The aim of this study was to investigate how patients perceive information and their health-related quality of life 1 month after discharge for colorectal cancer surgery. The aim was also to compare these results with the first 2 weeks at home and to identify factors related to the perception of information. One hundre... | 25,263,626 | [
0.1459147,
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0.1463269,
0.04122694,
0.2680275,
-0.01824362,
0.2190907,
-0.111554... |
Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta-analysis. | We aimed to assess the effects of childhood obesity prevention programmes on blood lipids in high-income countries. We searched MEDLINE®, Embase, PsychInfo, CINAHL®, clinicaltrials.gov, and the Cochrane Library up to 22 April 2013 for relevant randomized controlled trials, quasi-experimental studies and natural experim... | 25,263,653 | [
0.1394806,
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0.262236,
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0.2920226,
-0.2139482,
... |
1α,25(OH)2D3 differentially regulates miRNA expression in human bladder cancer cells. | Bladder cancer is the fourth most commonly diagnosed cancer in men and eighth leading cause of cancer-related death in the US. Epidemiological and experimental studies strongly suggest a role for 1α,25(OH)2D3 in cancer prevention and treatment. The antitumor activities of 1α,25(OH)2D3 are mediated by the induction of c... | 25,263,658 | [
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0.4410864,
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0.224646,
0.4805697,
0.6949409,
-0.2616784,
0.39... |
Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cells. | 1α,25(OH)2D3 regulates osteoblasts and chondrocytes via its membrane-associated receptor, protein disulfide isomerase A3 (Pdia3) in caveolae. 1α,25(OH)2D3 binding to Pdia3 leads to phospholipase-A2 (PLA2)-activating protein (PLAA) activation, stimulating cytosolic PLA2 and resulting in prostaglandin E2 (PGE2) release a... | 25,263,660 | [
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0.3163912,
0.4162478,
0.1403849,
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0.3... |
Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery. | The Polo-like kinase 1 (Plk1) plays a key role in regulating a broad spectrum of critical cell cycle events. Plk1 is a marker of cellular proliferation and has prognostic potential in different types of human tumors. In a series of preclinical studies, Plk1 has been validated as a cancer target. This prompted many phar... | 25,263,688 | [
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0.08200313,
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0.008658335,
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0.158575,
0.4503549,
0.2839347,
-0.2928374,
0.3... |
Maternal and perinatal mortality by place of delivery in sub-Saharan Africa: a meta-analysis of population-based cohort studies. | Facility-based delivery has gained traction as a key strategy for reducing maternal and perinatal mortality in developing countries. However, robust evidence of impact of place of delivery on maternal and perinatal mortality is lacking. We aimed to estimate the risk of maternal and perinatal mortality by place of deliv... | 25,263,746 | [
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0.2621274,
-0.246666,
-0.05066186,
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0.387893,
-0.04763... |
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