pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
25,076,938 | Is stemness Derived from Thyroid Cancer Cells? | {
"contexts": [
"One hypothesis for thyroid cancer development is its derivation from thyroid cancer stem cells (CSCs). Such cells could arise via different paths including from mutated resident stem cells within the thyroid gland or via epithelial to mesenchymal transition (EMT) from malignant cells since EMT is... | Our findings support our earlier hypothesis that stemness in thyroid cancer is derived via EMT rather than from resident thyroid stem cells. In mice with a thyroid-specific knock-in of oncogenic Braf (LSL-Braf((V600E))/TPO-Cre), the neoplastic changes were dependent on thyroid cell differentiation and the onset of stem... | yes |
25,092,576 | Does low RNA translation activit limit the efficacy of hydrodynamic gene transfer to pig liver in vivo? | {
"contexts": [
"Hydrodynamic gene delivery has proved an efficient strategy for nonviral gene therapy in the murine liver but it has been less efficient in pigs. The reason for such inefficiency remains unclear. The present study used a surgical strategy to seal the whole pig liver in vivo.",
"A solution of ... | The results suggest that the low activity of mRNA translation limits the final efficacy of the gene transfer procedure. On the other hand, the gold nanoparticles study suggests that elongated DNA conformation could offer advantages in that the access of 15-nm particles is very limited. | yes |
25,088,002 | Is p300-dependent STAT3 acetylation necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells? | {
"contexts": [
"To explore the signal transducer and activator of transcription 3 (STAT3) signaling pathway, especially STAT3 acetylation, in angiotensin II (Ang II)-induced pro-fibrotic responses in renal tubular epithelial cells.",
"Rat renal tubular epithelial cell line (NRK-52E) was used. STAT3 acetylati... | p300-dependent STAT3 acetylation is necessary for Ang II-induced STAT3 phosphorylation and the consequent pro-fibrotic responses in renal tubular epithelial cells in vitro. | yes |
25,081,727 | Is bevacizumab concomitant with chemotherapy effective in treating Chinese patients with advanced non-squamous non-small cell lung cancer? | {
"contexts": [
"To retrospectively review the safety and clinical efficacy of bevacizumab concomitant with chemotherapy in Chinese patients with advanced non-squamous non-small cell lung cancer (NSNSCLC).",
"Clinical data for 79 patients with NSNSCLC who received bevacizumab concomitant with chemotherapy in ... | Bevacizumab concomitant with chemotherapy is effective and the related toxicity can be well tolerated in Chinese patients with NSNSCLC. | yes |
25,076,606 | Does why TQM work in Iranian healthcare organisations? | {
"contexts": [
"Despite the potential benefits of total quality management (TQM), many healthcare organisations encountered difficulties in its implementation. The purpose of this paper is to explore the barriers to successful implementation of TQM in healthcare organisations of Iran.",
"This study involved ... | Understanding the factors that are likely to obstruct TQM implementation would enable managers to develop more viable strategies for achieving business excellence. | no |
25,071,926 | Do autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits? | {
"contexts": [
"As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of s... | Our findings clearly demonstrate that Dlgap2 plays a vital role in social behaviors and proper synaptic functions of the OFC. Moreover, these results may provide valuable insights into the neuropathology of autism. | yes |
25,081,811 | Does next-generation sequencing reveal large connected networks of intra-host HCV variants? | {
"contexts": [
"Next-generation sequencing (NGS) allows for sampling numerous viral variants from infected patients. This provides a novel opportunity to represent and study the mutational landscape of Hepatitis C Virus (HCV) within a single host.",
"Intra-host variants of the HCV E1/E2 region were extensive... | Most intra-host variants are organized into distinct single-mutation components that are: well separated from each other, represent genetic distances between viral variants, robust to sampling, reproducible and likely seeded during transmission events. Facilitated by NGS, large components offer a novel evolutionary fra... | yes |
25,092,172 | Does stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbate liver injury and fibrosis? | {
"contexts": [
"The role of signal transducer and activator of transcription 3 (Stat3) in liver fibrosis is still controversial. Since hepatic stellate cells (HSCs) and transforming growth factor-β1 (TGF-β1) are central to the fibrogenesis, our goal was to clarify the mechanism of Stat3 crosslinking of TGF-β1 si... | We provide a novel role of Stat3 cooperating TGF-β1 in activation and anti-apoptotic effect of HSCs. Stat3 worsens liver fibrosis through the up-regulation of TGF-β1 and fibrotic product expression. | yes |
25,069,610 | Does astragalin inhibit airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling? | {
"contexts": [
"Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in... | Astragalin ameliorated oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling. Therefore, astragalin may be a potent agent antagonizing endotoxin-induced oxidative stress leading to airway dysfunction and inflammation. | yes |
25,075,988 | Is physical activity associated with elevated arterial stiffness in patients with lumbar disk herniation? | {
"contexts": [
"A cross-sectional study in a general health examination.",
"To investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and lumbar disk herniation (LDH).",
"Lumbar disk herniation (LDH) is a major cause of low back pain and sciatica. Various vascular risk factors su... | The findings showed that LDH patients had higher baPWV levels. In addition, reduced physical activity was a risk factor contributing to increased baPWV. Further studies are warranted to determine the role of baPWV in LDH. | yes |
25,074,566 | Does effective treatment with intravenous immunoglobulins reduce autoreactive T-cell response in patients with CIDP? | {
"contexts": [
"To investigate changes in autoreactive T-cell responses against PMP-22 and P2 antigen as well as a T-cell memory repertoire in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) induced by repeated intravenous immunoglobulin (IVIg) treatment.",
"In an observational trial, ... | Our data demonstrate that immunomodulatory treatment with IVIgs on a long-term basis reduces the autoreactive T-cell response against PMP-22 and P2-antigens, which may be influenced by the altered maintenance of CD8 and CD4 effector/memory T-cell subsets towards a more anti-inflammatory immune status. Elevated PMP-22 a... | yes |
25,098,018 | Does self-controlled practice enhance motor learning in introverts and extroverts? | {
"contexts": [
"The purpose of the present study was to investigate the effects of self-controlled feedback on the learning of a sequential-timing motor task in introverts and extroverts.",
"Fifty-six university students were selected by the Eysenck Personality Questionnaire. They practiced a motor task cons... | We conclude that self-controlled practice enhances motor learning in introverts and extroverts. | yes |
25,089,641 | Does interatrial septum motion but not Doppler assessment predict elevated pulmonary capillary wedge pressure in patients undergoing cardiac surgery? | {
"contexts": [
"Left atrial pressure and its surrogate, pulmonary capillary wedge pressure (PCWP), are important for determining diastolic function. The role of transthoracic echocardiography (TTE) in assessing diastolic function is well established in awake subjects. The objective was to assess the accuracy of ... | Doppler assessment of PCWP was neither sensitive nor specific enough to be clinically useful in anesthetized patients with mechanical ventilation. The fixed curve pattern of the interatrial septum was the best predictor of raised PCWP. | yes |
25,088,672 | Is hashimoto 's disease a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria? | {
"contexts": [
"The precise pathogenesis of chronic spontaneous urticaria (CSU) remains unknown. However, an important association between CSU and autoimmune disorders such as Hashimoto's disease (HD) has been reported. We investigated the frequency of HD as a comorbidity of CSU and the prevalence rate of autore... | The comorbidity rate of HD in CSU patients was high, and such patients tended to have a positive ASST. Thyroid therapy in CSU patients with HD can lead to a considerable remission of urticarial symptoms, which may suggest that HD is possibly involved in the aetiology of CSU, or is at least a potential exacerbating fact... | yes |
25,096,451 | Does gender difference affect the outcomes of eccentric rotational acetabular osteotomy used in hip dysplasia? | {
"contexts": [
"Various types of periacetabular osteotomies have been proposed to treat acetabular dysplasia for young and active patients. Acetabular dysplasia is prevalent in women and rare in men, therefore few reports exist concerning periacetabular osteotomy of male patients. The purpose of this study is to... | The mean operative time and the blood loss were not significantly different between male and female patients. Postoperative CE angle tended to be smaller in male than female patients. The survival rate was not significantly different between males and females. Gender difference did not affect the clinical outcomes of E... | no |
25,099,082 | Is physician preference a major factor in management of vesicoureteral reflux? | {
"contexts": [
"Known factors affecting the management of vesicoureteral reflux (VUR) include reflux grade, infection frequency, age and gender. We hypothesized that provider preference is highly associated with management.",
"Utilizing the national billing database, Faculty Practice Solutions Center, a mult... | A surgeon's historic Deflux utilization was the most important predictor of VUR surgery type. Although data on reflux grade were not available, analysis of patient and surgeon characteristics suggests that surgeon preference is the first or second most critical factor in determining a patient's treatment. | yes |
25,086,748 | Are filaggrin loss-of-function mutations a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate? | {
"contexts": [
"Filaggrin (FLG) is a major protein component of the stratum corneum (SC) layer, and FLG loss-of-function mutations are a predisposing factor for atopic dermatitis (AD). Previous cohort studies of children from northern and western Europe have reported FLG loss-of-function mutation frequencies of ... | The FLG loss-of-function mutation frequency was not significantly different between the AD and non-AD groups in a cohort of children from Ishigaki Island, which has a subtropical climate, suggesting that FLG loss-of-function mutations are not always a predisposing factor for AD prevalence. | no |
25,090,450 | Does administrative Database Research overestimate the Rate of Interval Colon Cancer? | {
"contexts": [
"Our study reexamines the prevalence of interval colorectal cancer (I-CRC) by manually reviewing CRC cases at a single institution.",
"In 2% to 8% of patients with CRC, diagnosis occurs during the interval 6 to 36 months after a cancer-free colonoscopy. Rates are often determined by linking th... | The prevalence of I-CRC at our institution before adjustment was comparable with previously reported rates. This proportion was 47% lower after adjusting for administrative errors placing our figure at the lower end of reported I-CRC incidence. Reported rates of I-CRC may be falsely elevated due to errors unique to mer... | yes |
25,091,012 | Does complement protein C1q promote macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins? | {
"contexts": [
"Innate immune protein C1q plays a dual role in the chronic inflammatory disease of atherosclerosis. Complement activation via C1q exacerbates pathology in the atherosclerotic lesion in later stages of the disease. However, in early stages of disease C1q is protective. We hypothesize that compleme... | C1q-polarization of macrophages toward an anti-inflammatory (M2-like) phenotype may be important in dampening inflammation in the early atherosclerotic lesion. Further investigation of molecular pathways targeted by C1q may provide novel therapeutic targets for this disease. | yes |
25,100,637 | Does virtual planning of complex head and neck reconstruction result in satisfactory match between real outcomes and virtual models? | {
"contexts": [
"The reconstruction of large facial bony defects using microvascular transplants requires extensive surgery to achieve full rehabilitation of form and function. The purpose of this study is to measure the agreement between virtual plans and the actual results of maxillofacial reconstruction.",
... | Virtual plans for mandibular and maxillofacial reconstruction can be realised with excellent match. | yes |
25,086,187 | Does an accelerated infliximab induction regimen reduce the need for early colectomy in patients with acute severe ulcerative colitis? | {
"contexts": [
"Administration of infliximab to patients with acute severe ulcerative colitis (ASUC) (rescue therapy) can reduce the rate of early colectomy (within 12 months), but long-term rates of colectomy are the same as those of the pre-biologic era for these patients. The half-life of infliximab is shorte... | In patients with ASUC, an accelerated infliximab induction strategy reduces the need for early colectomy. An intensified infliximab dosing strategy in response to clinical or laboratory signs of breakthrough inflammation merits consideration in prospective studies. | yes |
25,086,183 | Does combination of dehydroepiandrosterone and orthovanadate administration reduce intestinal leukocyte recruitment in models of experimental sepsis? | {
"contexts": [
"Dehydroepiandrosterone (DHEA) was shown to improve the immune function and survival in experimental sepsis. This study examined the effect of DHEA on intestinal leukocyte recruitment during experimental sepsis, considering factors of gender (male, female and ovariectomized female animals) and com... | Our results indicate that DHEA is able to reduce intestinal leukocyte recruitment induced by experimental sepsis. Combination of DHEA with OV inhibits leukocyte adherence to intestinal endothelium, similar to what is achieved by the single administration of DHEA but with significantly improved FCD. These findings sugge... | yes |
25,080,266 | Does psychological distress negatively affect self-assessment of shoulder function in patients with rotator cuff tears? | {
"contexts": [
"In many areas of orthopaedics, patients with greater levels of psychological distress report inferior self-assessments of pain and function. This effect can lead to lower-than-expected baseline scores on common patient-reported outcome scales, even those not traditionally considered to have a psy... | Higher levels of psychological distress are associated with inferior baseline patient self-assessment of shoulder pain and function using the VAS, the Simple Shoulder Test, and the American Shoulder and Elbow Surgeons score. Longitudinal followup is warranted to clarify the relationship between distress and self-percei... | yes |
25,080,260 | Does drought degree constrain the beneficial effects of a fungal endophyte on Atractylodes lancea? | {
"contexts": [
"Plants, fungal endophytes (FEs) and the changing environment interact with each other forming an interlaced network. This study evaluates nonadditive and interactive effects of the FE Acremonium strictum and drought treatment on Atractylodes lancea plantlets.",
"By applying FEs (meristem cult... | Plant traits plasticity was conferred by dual effects of drought stress and FEs, and these factors are interactive. Although FEs can help plants cope with drought stress, the beneficial effects are strictly constrained by drought degree. | yes |
25,079,219 | Does inhibition of euchromatic histone methyltransferase 1 and 2 sensitize chronic myeloid leukemia cells to interferon treatment? | {
"contexts": [
"H3K9 methylation is one of the essential histone post-translational modifications for heterochromatin formation and transcriptional repression. Recently, several studies have demonstrated that H3K9 methylation negatively regulates the type I interferon response.",
"We report the application o... | Our study sheds light on the role of EHMT1 and EHMT2 as potential targets in improving the efficacy of standard treatments of CML. | yes |
25,086,551 | Does cT substitute derived from MR images reconstructed with parallel imaging? | {
"contexts": [
"Computed tomography (CT) substitute images can be generated from ultrashort echo time (UTE) MRI sequences with radial k-space sampling. These CT substitutes can be used as ordinary CT images for PET attenuation correction and radiotherapy dose calculations. Parallel imaging allows faster acquisit... | SPIRiT marginally improved the CT substitute quality for a given number of radial spokes as compared to gridding. However, the increased reconstruction time of non-Cartesian parallel imaging reconstruction is difficult to motivate from this improvement. Because the CT substitute algorithm was insensitive to moderate su... | yes |
25,077,470 | Does increased nucleated red blood cells count in prolonged rupture of membranes is not erythropoietin driven? | {
"contexts": [
"The aim of this study is to examine the hypothesis that prolonged rupture of membranes (PROM) is associated with increased cord blood erythropoietin (EPO) concentrations, proportional to the duration of ruptured membranes.",
"This study is a prospective, cross-sectional, observational (nonint... | Cord blood concentrations of EPO do not appear to be significantly affected by the duration of ruptured membranes. We speculate that erythropoiesis is upregulated in PROM by mechanisms that involve the production of cytokines and are not EPO driven. | yes |
25,070,454 | Does [ Inflammation promote the development of colitis-associated colorectal cancer ]? | {
"contexts": [
"To confirm that the severity of inflammation can promote the colitis-associated colorectal cancer(CAC) and explore the function of STAT3 signal pathway in CAC.",
"Mutagenic agent azoxymethane(AOM) and pro-inflammatory agent dextran sodium sulfate salt (DSS) were used to develop a mouse model ... | Inflammation can promote the colitis-associated CAC. And the activation of STAT3 signal pathway may promote the development of CAC. | yes |
25,099,548 | Is higher fructose intake inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults? | {
"contexts": [
"High fructose intake has been suggested to be a key factor that induces nonalcoholic fatty liver disease (NAFLD), but the evidence from large epidemiologic studies is lacking.",
"We examined the cross-sectional association between fructose intake and NAFLD by using the Fatty Liver Index (FLI)... | Our cross-sectional results did not support the current hypothesis that high intake of fructose is associated with a higher prevalence of NAFLD as assessed by using the FLI and NAFLD liver fat score. | yes |
25,070,826 | Does formononetin attenuate hydrogen peroxide ( H2O2 ) -induced apoptosis and NF-κB activation in RGC-5 cells? | {
"contexts": [
"Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). Several studies suggest that the oxidative stress plays a role in the pathogenesis of diabetic retinopathy in adults. Formononetin is a flavone with powerful antioxidant properties that exist... | Formononetin may be developed as a antioxidant drug to treat diabetic retinopathy. | yes |
25,085,593 | Does zuo Jin Wan reverse P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway? | {
"contexts": [
"Zuo-Jin-Wan (ZJW), a traditional Chinese medicine formula, has been identified to be effective against drug resistance in cancer. In the present study, we investigated the effect of ZJW on acquired oxaliplatin-resistant and the PI3K/Akt/NF-κB pathway in vitro.",
"We tested the dose-response r... | Our study has provided the first direct evidence that ZJW reverses drug-resistance in human colorectal cancer by blocking the PI3K/Akt/NF-κB signaling pathway, and could be considered as a useful drug for cancer therapy. | yes |
25,100,054 | Do patients with Pathologically Proven Renal Disease Have Similar Declines in Renal Function Following Robot-Assisted Partial Nephrectomy? | {
"contexts": [
"To determine if patients with pathological, medical renal disease, defined as evidence of pathological abnormalities indicative of renal damage in the non-neoplastic partial nephrectomy specimens, have worsened functional outcomes following robot-assisted partial nephrectomy.",
"Sixty patient... | The presence of pathological renal disease in non-neoplastic renal tissue did not place patients at risk for worsened postoperative complications or renal function deterioration following robot-assisted partial nephrectomy. | yes |
25,085,642 | Is neuronal loss an early component of subacute sclerosing panencephalitis? | {
"contexts": [
"We performed diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) studies in a group of patients with subacute sclerosing panencephalitis (SSPE) in order to estimate the pathologic process underlying the phenotypic variability.",
"Patients with SSPE who had MRI including D... | The combination of MRS and diffusion MRI findings suggests neuronal loss can be a primary target in rapidly or subacutely progressing SSPE, and preservation or regeneration of axonal structure may be beneficial in chronic cases. | yes |
25,100,392 | Is osteoprotegerin a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes? | {
"contexts": [
"Coronary artery calcification (CAC) is a prominent feature of atherosclerosis and is associated with cardiovascular events. In vitro studies have suggested that osteoprotegerin (OPG) and osteocalcin (OC) exert anticalcification potential in the vessel wall. The objective of this study was to inve... | Our results suggest that OPG is a more useful serum biomarker than OC or ucOC for identifying those at increased risk of arterial calcification in type 2 diabetes. | yes |
25,100,396 | Does inconsistency in filling in the bottom of the spine bone map affect reported spine bone mineral density? | {
"contexts": [
"We hypothesized that variability from year to year in how much of the bone map was filled in at the bottom of the spine region of interest (ROI) contributes substantially to variability in measurement of spine bone mineral density (BMD).",
"A total of 110 spine BMDs with defects in the bone m... | When there is a noticeable defect in the bottom of the spine bone map, filling this defect in consistently eliminates a significant source of variability in analysis of spine BMDs and might allow us to achieve smaller LSCs. | yes |
25,096,990 | Does chronic intermittent hypobaric hypoxia ameliorate ischemia/reperfusion-induced calcium overload in heart via Na/Ca2+ exchanger in developing rats? | {
"contexts": [
"Chronic intermittent hypobaric hypoxia (CIHH) protects the heart against ischemia/reperfusion (I/R) injury. This study investigated the calcium homeostasis mechanism and the role of Na(+)/Ca(2+) exchanger (NCX) in the cardiac protective effect of CIHH in developing rats.",
"Neonatal male rats... | These data suggest that CIHH protects developing rat hearts during I/R by enhancing the resistance against calcium overload and by preserving normal I(Na/Ca) and NCX1 protein. PKC activation might be involved in this protective process of CIHH. | yes |
25,086,595 | Does diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predict patient outcomes? | {
"contexts": [
"Diffusion-weighted MRI (DWI) has been used in neurosurgical practice mainly to distinguish cerebral metastases from abscess and glioma. There is evidence from other solid organ cancers and metastases that DWI may be used as a biomarker of prognosis and treatment response. We therefore investigate... | DWI demonstrates changes in the tumor, across the tumor edge and in the peritumoral region which may not be visible on conventional MRI and this may be useful in predicting patient outcomes for operated cerebral metastases. | yes |
25,097,219 | Is sumo E2 enzyme UBC9 required for efficient protein quality control in cardiomyocytes? | {
"contexts": [
"Impairment of proteasomal function is pathogenic in several cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for cellular pro... | UBC9 plays a significant role in cardiomyocyte protein quality control, and its activity can be exploited to reduce toxic levels of misfolded or aggregated proteins in cardiomyopathy. | yes |
25,097,217 | Are spinal cord grey matter abnormalities associated with secondary progression and physical disability in multiple sclerosis? | {
"contexts": [
"In multiple sclerosis (MS), pathological studies have identified substantial demyelination and neuronal loss in the spinal cord grey matter (GM). However, there has been limited in vivo investigation of cord GM abnormalities and their possible functional effects using MRI combined with clinical e... | The study findings suggest that pathological involvement of the spinal cord GM contributes significantly to physical disability in relapse-onset MS and SPMS in particular. | yes |
25,075,074 | Does age worsen the efficacy nor tolerance to combined induction therapies in locally advanced non-small cell lung cancer? | {
"contexts": [
"One third of non-small cell lung cancer (NSCLC) affects elderly patients in a locally advanced (LA) stage. Induction therapy followed by a curative approach is becoming the standard-of-care for LA-NSCLC.",
"We compared the efficacy and tolerance to induction chemotherapy or chemo-radiation fo... | Age by itself did not significantly worsen either the efficacy or tolerance to combined induction and definitive treatment in patients with LA-NSCLC and Eastern Cooperative Oncology Group performance status 0-2. | no |
25,081,971 | Do parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells? | {
"contexts": [
"Successful cancer treatments still require more compounds to be isolated from natural sources. Thus, we have investigated anti-proliferative/apoptotic effects of methanolic extracts of lichen species Parmelia sulcata Taylor and Usnea filipendula Stirt on human lung cancer (A549, PC3), liver cance... | In this study, methanolic extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells. | yes |
25,095,827 | Is parathyroid hormone associated with the LV mass after aortic valve replacement? | {
"contexts": [
"LV hypertrophy (LVH) is frequent after aortic valve replacement (AVR) and is often associated with comorbidities, including hypertension, obesity, renal failure and prosthesis-patient mismatch (PPM). However, whether other biological mechanism(s) may participate to LVH after AVR is still unknown.... | After AVR, the level of PTH is independently associated with LVH. In turn, the level of PTH is related with the renal function and the level of 25-OHD. | yes |
25,088,559 | Does the conserved discs-large binding partner Banderuola regulate asymmetric cell division in Drosophila? | {
"contexts": [
"Asymmetric cell division (ACD) is a key process that allows different cell types to be generated at precisely defined times and positions. In Drosophila, neural precursor cells rely heavily on ACD to generate the different cell types in the nervous system. A conserved protein machinery that regul... | Bnd is a novel regulator of ACD in different types of cells. Our data place Bnd at the top of the hierarchy of the factors involved in ACD, suggesting that its main function is to mediate the localization and function of the Dlg tumor suppressor. Bnd has an antioncogenic function that is redundant with Dlg, and the phy... | yes |
25,088,558 | Does pINK1 trigger autocatalytic activation of Parkin to specify cell fate decisions? | {
"contexts": [
"The PINK1-Parkin pathway is known to play important roles in regulating mitochondria dynamics, motility, and quality control. Activation of this pathway can be triggered by a variety of cellular stress signals that cause mitochondrial damage. How this pathway senses different levels of mitochondr... | Autocatalytic activation of Parkin bolsters its accumulation on mitochondria and apoptotic response to valinomycin. Our results suggest that PINK1-Parkin constitutes a damage-gated molecular switch that governs cellular-context-specific cell fate decisions in response to variable stress stimuli. | yes |
25,088,556 | Do integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions? | {
"contexts": [
"A complex network of putative molecular interactions underlies the architecture and function of cell-matrix adhesions. Most of these interactions are implicated from coimmunoprecipitation studies using expressed components, but few have been demonstrated or characterized functionally in living ce... | These observations suggest a working model for NA assembly whereby transient α-actinin-integrin complexes help nucleate NAs within the lamellipodium. Subsequently, integrin complexes containing kindlin, but not talin, emerge. Once NAs have formed, myosin II activity promotes talin association with the integrin-kindlin ... | yes |
25,077,942 | Does short-term glucocorticoid treatment cause spinal osteoporosis in ovariectomized rats? | {
"contexts": [
"In humans, glucocorticoid-induced osteoporosis is the most common cause of medication-induced osteoporosis. Recent clinical data suggest that glucocorticoid therapy increases the risk of vertebral fractures within a short treatment period. Therefore, this study aimed at investigating vertebral bo... | Short-term glucocorticoid treatment of ovariectomized rats indicates according to DEXA standards a severe osteoporotic bone status in vertebral bone. Nonetheless, dysfunctional bone anabolism and enhanced bone catabolism are observed. Alterations of bone extracellular matrix proteins that correlate to inferior mechanic... | yes |
25,082,964 | Does graft shape affect midfoot correction and forefoot loading mechanics in lateral column lengthening osteotomies? | {
"contexts": [
"Adult acquired flatfoot deformity is characterized by midfoot abduction and collapse of the medial longitudinal arch. Lateral column lengthening osteotomies primarily correct the abduction deformity, but the effects of graft shape on deformity correction and forefoot loading are unclear. Therefor... | Graft shape had no effect on the correction of talonavicular abduction or dorsiflexion but did influence coronal plane motion and forefoot loading mechanics. Also, overcorrecting the abduction deformity was predictive of increased lateral plantar pressures. | yes |
25,090,267 | Are iGF2 expression and β-catenin levels increased in Frozen Shoulder Syndrome? | {
"contexts": [
"Frozen Shoulder Syndrome is a fibrosis of the shoulder joint capsule that is clinically associated with Dupuytren's disease, a fibrosis of the palmar fascia. Little is known about any commonalities in the pathophysiology of these connective tissue fibroses. β-catenin, a protein that transactivate... | As in Dupuytren's disease, β-catenin levels and IGF2 expression are elevated in Frozen Shoulder Syndrome. These findings support the hypothesis that these connective tissue fibroses share a common pathophysiology. | yes |
25,096,633 | Does comparative genomics of 274 Vibrio cholerae genomes reveal mobile functions structuring three niche dimensions? | {
"contexts": [
"Vibrio cholerae is a globally dispersed pathogen that has evolved with humans for centuries, but also includes non-pathogenic environmental strains. Here, we identify the genomic variability underlying this remarkable persistence across the three major niche dimensions space, time, and habitat.",... | Our analysis revealed that genomic variations, in particular mobile functions including phages, prophages, transposable elements, and plasmids underlie the metadata structuring in each of the three niche dimensions. This underscores the role of phages and mobile elements as the most rapidly evolving elements in bacteri... | yes |
25,100,892 | Does caffeine modify blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes? | {
"contexts": [
"The study investigated the effect of supplementation with maltodextrin (CHO) alone or associated to caffeine during exercise in T2DM subjects.",
"Pilot study, using eight subjects with T2DM, aged 55±10 years, received CHO (1 g/kg) or caffeine (1.5 mg/kg) alone or associated before exercise pr... | Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients. | yes |
25,093,233 | Is decrease in daytime sleeping associated with improvement in cognition after hospital discharge in older adults? | {
"contexts": [
"To examine the relationship between changes in objectively assessed sleep and global cognitive functioning from inpatient postacute rehabilitation to 6-month follow-up.",
"Secondary analysis of two prospective, longitudinal studies.",
"Inpatient rehabilitation units at a Veterans Affairs ... | Older adults whose daytime sleeping decreased after hospital discharge also experienced improvements in cognitive functioning at 6 month follow-up. As such, daytime sleep may represent a promising candidate for targeted interventions aimed at promoting cognitive recovery after hospital discharge. | yes |
25,083,175 | Does co-Administration of Metformin and N-Acetyl Cysteine fail to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI? | {
"contexts": [
"Studies have demonstrated the efficacy of metformin (MTF ) in reducing insulin resistance and N-acetyl cysteine (NAC) in inhibiting oxidative stress which are involved in the pathogenesis of polycystic ovarian syndrome (PCOS). We aimed to compare the effects of MTF and NAC combination on serum me... | CONSIDERING THE ADVERSE EFFECT OF COMBINATION THERAPY, WE PROPOSED THE CONADMINISTRATION MIGHT HAVE NO BENEFICIAL EFFECT FOR PCOS PATIENT DURING COURSE OF OVULATION INDUCTION OF ICSI (REGISTRATION NUMBER: IRCT201204159476N1). | yes |
25,070,319 | Is bone mineral content in patients with congenital generalized lipodystrophy unaffected by metreleptin replacement therapy? | {
"contexts": [
"Leptin alters bone and mineral metabolism in rodents, but this has not been verified in humans. PATIENTS with congenital generalized lipodystrophy (CGL) have low leptin due to deficient adipose mass and serve as models of leptin deficiency and replacement.",
"To study the effects of recombina... | In contrast to rodent models, CGL patients have increased BMC in the leptin-deficient state, which does not change with leptin replacement. The high BMC in these patients is partially explained by high lean mass and tall stature. | yes |
25,069,600 | Is p16 ( INK4a ) overexpression linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells? | {
"contexts": [
"p16(INK4a) Is overexpressed in almost all precancerous and carcinomatous lesions of the uterine cervix, secondary to interference between high-risk human papillomaviruses (hr-HPVs) and the retinoblastoma gene product. Overexpression of p16(INK4a) has also been identified in patients with high-gra... | Our study shows a low prevalence of hr-HPVs in the urine of patients with high-grade urothelial malignancy. In those, p16(INK4a) overexpression occurs in the absence of demonstrable HPV DNA in the tissue sections, contrary to what is noted in gynecopathology. | no |
25,099,262 | Does the PROMIS physical function correlate with the QuickDASH in patients with upper extremity illness? | {
"contexts": [
"To assess disability more efficiently with less burden on the patient, the National Institutes of Health has developed the Patient Reported Outcomes Measurement Information System (PROMIS) Physical Function-an instrument based on item response theory and using computer adaptive testing (CAT). Ini... | The PROMIS Physical Function instrument may be used as an upper extremity disability measure, as it correlates with the QuickDASH questionnaire, and both instruments are influenced most strongly by the degree to which pain interferes with achieving goals. | yes |
25,073,577 | Does multidisciplinary care improve amputation-free survival in patients with chronic critical limb ischemia? | {
"contexts": [
"This study was conducted to quantify the effect of multidisciplinary care (MDC) on amputation-free survival (AFS) and wound healing within a chronic critical limb ischemia (CLI) population.",
"We performed a retrospective, single-center cohort study of consecutive CLI patients presenting to t... | MDC pathways for the management of a population of CLI patients improved AFS by greater than twofold and should be the standard of care for the CLI population. Baseline nonambulatory status and unrevascularized patients also predict worse AFS. Wound healing remains prolonged regardless of preoperative or postoperative ... | yes |
25,081,604 | Is unilateral hearing loss associated with a negative effect on language scores in adolescents? | {
"contexts": [
"To determine if adolescents with unilateral hearing loss (UHL) demonstrate worse language skills than their siblings with normal hearing (NH).",
"Case-control study of 12-17-year-old adolescents with UHL (20 cases) compared with sibling controls with NH (13 controls).",
"Scores on the ora... | These findings suggest that UHL in adolescents is associated with a negative effect on standardized language scores and IQ. They also demonstrate that the developmental gap between children with UHL and children with NH does not resolve as the children progress into adolescence and may even widen as the children grow o... | yes |
25,080,456 | Is initiation of nutritional support delayed in critically ill obese patients : a multicenter cohort study? | {
"contexts": [
"A high catabolic rate characterizes the acute phase of critical illness. Guidelines recommend an early nutritional support, regardless of the previous nutritional status.",
"We aimed to assess whether the nutritional status of patients, which was defined by the body mass index (BMI) at admiss... | The initiation of nutritional support was delayed in obese ICU patients. Randomized controlled trials that address consequences of early compared with delayed beginnings of nutritional support in critically ill obese patients are needed. | yes |
25,090,714 | Does [ Gambogenic acid induce mitochondria-dependent apoptosis in human gastric carcinoma cell line ]? | {
"contexts": [
"To study the effects of Gambogenic acid (GNA) on the growth of human gastric carcinoma cell line MGC-803 and its underlying mechanisms.",
"MTT assay was used to measure the cell viability. Apoptosis, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) were detected using flo... | GNA induces mitochondria-dependent apoptosis and increases P53 expression in human gastric carcinoma cell line. | yes |
25,086,327 | Is cigarette smoking associated with a reduction in the risk of incident gout : results from the Framingham Heart Study original cohort? | {
"contexts": [
"Cigarette smoking is correlated with other risk factors for gout such as adiposity and alcohol intake. The goal of this study was to study the direction and magnitude of association between cigarette smoking and risk for gout.",
"We analysed 54-year follow-up data (1948-2002) for 2279 men and... | Cigarette smoking is associated with lower incidence of gout and this is not explained by differences in the prevalence of risk factors. The mechanistic underpinnings of this epidemiological finding merits further study. | yes |
25,077,799 | Does relative influence of genetics and shared environment on child mental health symptoms depend on comorbidity? | {
"contexts": [
"Comorbidity among childhood mental health symptoms is common in clinical and community samples and should be accounted for when investigating etiology. We therefore aimed to uncover latent classes of mental health symptoms in middle childhood in a community sample, and to determine the latent gen... | We conclude that symptom classes are largely similar across sexes in middle childhood. Heritability was moderate for all classes, but shared environment played a greater role for classes in which no one type of symptom predominated. | yes |
25,099,226 | Are prepregnancy body mass index and prenatal fasting glucose effective predictors of early postpartum metabolic syndrome in Spanish mothers with gestational diabetes? | {
"contexts": [
"Gestational diabetes mellitus (GDM) may be an expression of early metabolic syndrome. It is unknown whether weight and/or glucose parameters assessed at GDM pregnancies predict the risk of metabolic syndrome at the early postpartum period.",
"A group of women with GDM (N=1512) was evaluated a... | Women having GDM are at threat of early postpartum metabolic syndrome. This risk can be easily identified by assessing prepregnancy BMI and antenatal fasting glycemia in the first pregnancy visit. | yes |
25,072,259 | Does glutamine depletion by crisantaspase hinder the growth of human hepatocellular carcinoma xenografts? | {
"contexts": [
"A subset of human hepatocellular carcinomas (HCC) exhibit mutations of β-catenin gene CTNNB1 and overexpress Glutamine synthetase (GS). The CTNNB1-mutated HCC cell line HepG2 is sensitive to glutamine starvation induced in vitro with the antileukemic drug Crisantaspase and the GS inhibitor methio... | The combination of Crisantaspase and MSO reduces glutamine supply to CTNNB1-mutated HCC xenografts and hinders their growth. | yes |
25,088,035 | Is high expression of GTPase regulator associated with the focal adhesion kinase ( GRAF ) a favorable prognostic factor in acute myeloid leukemia? | {
"contexts": [
"GRAF is a recognized tumor suppressor gene that was found inactivated in AML. However, the prognostic role of a GRAF transcript has not been studied in patients with AML.",
"In this study, we investigated the expression of the GRAF transcript by real time quantitative PCR in 60 AML patients a... | We provide evidence that high GRAF expression is a favorable prognostic marker in patients with AML. | yes |
25,070,676 | Does progression rates and sample size estimate for PPMS based on the CLIMB study population? | {
"contexts": [
"The clinical trial design for primary progressive multiple sclerosis (PPMS) requires understanding of disability progression in modern patient cohorts.",
"The objective of this paper is to characterize demographic and clinical characteristics of PPMS and assess rate of disability progression.... | Our modern PPMS cohort is demographically similar to previously studied cohorts. PPMS is associated with faster disability accrual than ROMS. Current real-world observations of time to sustained progression will inform design of new clinical trials for PPMS. | yes |
25,085,297 | Does microelectronic wear-time documentation of removable orthodontic devices detect heterogeneous wear behavior and individualizes treatment planning? | {
"contexts": [
"The aim of this study was to investigate whether microelectronic wear-time documentation can contribute to individualized orthodontic management.",
"The wear times and behaviors of 281 patients undergoing orthodontic treatment with removable appliances were quantified and analyzed using the T... | Both the duration of daily wear time and the wear behavior need to be considered to individualize the prescription for wear time; this is made possible with microelectronic wear-time documentation. Individual prescription changes based on the wear-time documentation can be arranged with patients in a shared decision-ma... | yes |
25,082,749 | Does protease-mediated human smooth muscle cell proliferation by urokinase require epidermal growth factor receptor transactivation by triple membrane signaling? | {
"contexts": [
"Urokinase (uPA) modulates cellular and extracellular matrix responses within the microenvironment of the vessel wall and has been shown to activate the epidermal growth factor receptor (EGFR). This study examines the role of the protease domain of uPA during EGFR activation in human vascular smoo... | In human coronary VSMC, uPA induces uPAR-independent, domain-dependent smooth muscle cell proliferation through transactivation of EGFR by a plasmin-mediated, ADAM-induced, and HB-EGF-dependent process, which is mediated by the intracellular pathways involving Gαi, Gβγ, src, and NAD(P)H oxidase. | yes |
25,083,033 | Does evaluation and comparison of high-level microwave oven disinfection with chemical disinfection of dental gypsum cast? | {
"contexts": [
"The aim of this study was to evaluate and compare microwave disinfection with chemical disinfection of dental gypsum casts.",
"A total of 120 casts were prepared from a silicone mold using Type III dental stone. Of the 120 casts, 60 casts were contaminated with 1 ml suspension of Staphylococc... | Within the limitation of this in vitro study, it was found that microwave disinfection of casts for 5 min at 900 W gives high-level disinfection that complies with the current infection control guidelines for the dental laboratory and microwave disinfection method is an effective and validated method as chemical disinf... | yes |
25,077,520 | Do neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro? | {
"contexts": [
"Neural crest stem cells derived from the boundary cap (bNCSCs), markedly promote survival, proliferation and function of insulin producing β-cells in vitro and in vivo after coculture/transplantation with pancreatic islets [ 1, 2 ]. Recently, we have shown that beneficial effects on β-cells requi... | These observations indicate that HF-NCSCs do not confer the same positive effect on β-cells as demonstrated for bNCSCs. Furthermore, these data suggest that induction of cadherin expression by HF-NCSCs may be useful for their ability to support β-cells in coculture and after transplantation. | yes |
25,097,000 | Is exclusive breastfeeding duration during the first 6 months of life positively associated with length-for-age among infants 6-12 months old , in Mangochi district , Malawi? | {
"contexts": [
"To examine the association between breastfeeding pattern and growth in the first year of life.",
"A cross-sectional survey was carried out on 349 mothers with infants <12 months in a rural and a semi-urban community in Mangochi district, Malawi. Data on socio-demographic characteristics, infa... | EBF in the first 6 months of life was associated with increased linear growth, but not weight gain, in later infancy. Promotion of EBF could reduce the prevalence of chronic child undernutrition in the study area. | yes |
25,073,972 | Does the transcription factor Ap-1 regulate monkey 20α-hydroxysteroid dehydrogenase promoter activity in CHO cells? | {
"contexts": [
"Monkey 20α-hydroxysteroid dehydrogenase (20α-HSD) is a catabolic enzyme responsible for converting progesterone into biologically inactive 20α-hydroxyprogesterone, thereby playing a key role in the estrous cycle or pregnancy and allowing ovulation and parturition to occur in most mammalian animal... | Our results indicate that the Ap-1 site (-281 → -274) (5'-TGTCTCAT-3') plays a crucial role in the activation of the monkey 20α-HSD gene. Thus, we demonstrated that monkey 20α-HSD promoter activity is regulated by the transcription factor Ap-1 in CHO-K1 cells. | yes |
25,071,612 | Are anxiety Disorders Associated with Reduced Heart Rate Variability : A Meta-Analysis? | {
"contexts": [
"Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history of medical disorders. While impaired vagal function, indicated by reductions in heart ra... | Anxiety disorders are associated with reduced HRV, findings associated with a small-to-moderate effect size. Findings have important implications for future physical health and well-being of patients, highlighting a need for comprehensive cardiovascular risk reduction. | yes |
25,089,279 | Do early results of a new rotating hinge knee implant? | {
"contexts": [
"Indication for rotating hinge (RH) total knee arthroplasty (TKA) includes primary and revision cases, with contradictory results. The aim of this study was to report prospective early results of a new modular rotating hinge TKA (EnduRo). For this implant several new design features and a new bear... | Our study shows excellent clinical results of the EnduRo TKA. Furthermore, no premature material failure or unusual biological response to the new bearing material could be detected. | yes |
25,090,687 | Does [ Essential oil from Artemisia lavandulaefolia induce apoptosis and necrosis of HeLa cells ]? | {
"contexts": [
"To investigate the effects of Artemisia lavandulaefolia essential oil on apoptosis and necrosis of HeLa cells.",
"Cell viability was assayed using MTT method. The morphological and structure alterations in HeLa cells were observed by microscopy. Furthermore, cell apoptosis was measured by DNA... | Essential oil from Artemisia lavadulaefolia can inhibit the proliferation of HeLa cells in vitro. Low concentration of essential oil from Artemisia lavadulaefolia can induce apoptosis, whereas high concentration of the compounds result in necrosis of HeLa cells. And,the mechanism may be related to the caspase-3-mediate... | yes |
25,070,815 | Does targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induce apoptosis of osteosarcoma cells in vitro? | {
"contexts": [
"To investigate the effect of targeted antiosteosarcoma methotrexate-bisphosphonate conjugate on growth inhibition and apoptosis in human osteosarcoma MG-63 cells.",
"MG-63 cells were treated with various concentrations of methotrexate-bisphosphonate conjugate and apoptosis was monitored via a... | A targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induces apoptosis in human osteosarcoma MG-63 cells. This new conjugate is a valuable experimental tool for the therapy of osteosarcoma. | yes |
25,097,127 | Does activation of microbubbles by low-level therapeutic ultrasound enhance the antitumor effects of doxorubicin? | {
"contexts": [
"To prove that DNA damage, intracellular reactive oxygen species (ROS) generation and loss of mitochondrial membrane potential (MMP) are contributing factors for the inhibition of cell proliferation induced by doxorubicin (DOX) administration combined with microbubble-assisted low-level therapeuti... | MB-US could increase the susceptibility of tumours to antineoplastic drugs, suggesting a potential clinical method for US-mediated tumour chemotherapy. | yes |
25,069,535 | Do dPP4 inhibitors increase differentially the expression of surfactant proteins in Fischer 344 rats? | {
"contexts": [
"Intact surface active agent (surfactant) composed of surfactant-associated proteins (SPs) and lipids is necessary for respiration and prevents alveoli from collapsing. CD26, a transmembrane glycoprotein exerting dipeptidyl peptidase activity (DPP4), highly expressed in lung parenchyma, is involve... | DPP4 inhibition influence differently the expression of surfactant proteins in healthy rats and may be suitable to elevate surfactant synthesis in different diseases accompanied with surfactant deficiencies. | yes |
25,074,374 | Is desert dust a risk factor for the incidence of acute myocardial infarction in Western Japan? | {
"contexts": [
"Recently, there has been increasing concern about adverse health effects of exposure to desert dust events. However, the association between dust and the incidence of ischemic heart diseases is unknown. The aim of the present study was to elucidate whether Asian dust (AD), a windblown sand dust o... | These data suggest that exposure to AD a few days before symptom onset is associated with the incidence of AMI. | yes |
25,071,310 | Is photodynamic Therapy with 5 % δ-Aminolevulinic Acid Safe and Effective Treatment of Acne Vulgaris in Japanese Patients? | {
"contexts": [
"Photodynamic therapy with aminolevulinic acid (ALA-PDT) is effective therapy for acne vulgaris; however, relatively strong side effects limit its wide usage. We have previously demonstrated that ALA-induced protoporphyrin IX distribution with lower concentrations and shorter contact time of ALA r... | Our protocol was effective for acne in Japanese and did not exhibit severe side effects. | yes |
25,098,104 | Is [ `` Second look '' after laparoscopic myomectomy -- that a prevention of postoperative adhesions ]? | {
"contexts": [
"To investigate the risk of adhesions after laparoscopic myomectomy (LM). To establish the percentage of adhesions, their kind, situation and magnitude.",
"For the period form June 2011 to November 2013 totally 81 patients were operated by LM. In the study only patients with intramural leymyom... | The factors, responsible for the formation of postoperative adhesions are: the location of the myoma in the posterior uterine wall, excessive accumulation of suturing materials and additional operative interventions. For patients underwent LM and willing pregnancy we recommend second look laparoscopy. | yes |
25,069,927 | Do evaluation of triple antibiotic paste removal by different irrigation procedures? | {
"contexts": [
"Regenerative endodontics aims to re-establish a functional pulp-dentin complex. First, the root canal system is disinfected primarily by irrigants and medicaments. Triple antibiotic paste (TAP), a commonly used intracanal medicament, has been shown to be directly toxic to stem cells at concentrat... | Current irrigation techniques do not effectively remove TAP from root canal systems, possibly because of its penetration and binding into dentin. However, calcium hydroxide is effectively removed with significant less residual presence. | yes |
25,088,216 | Does equisetum arvense ( common horsetail ) modulate the function of inflammatory immunocompetent cells? | {
"contexts": [
"In Europe, extracts of Equisetum arvense (common horsetail) have a long tradition in the treatment of inflammatory disorders. To understand the molecular basis for its use, we investigated the immunomodulatory capacity of a standardized commercially available common horsetail extract on human pri... | The data indicate that the used extract of Equisetum arvense interferes with the polyfunctionality of immunocompetent cells thereby providing an anti-inflammatory mode-of-action. | yes |
25,071,347 | Does remote ischemic postconditioning protect against gastric mucosal lesions in rats? | {
"contexts": [
"To investigate the protective effects of remote ischemic postconditioning (RIP) against limb ischemia-reperfusion (IR)-induced gastric mucosal injury.",
"Gastric IR was established in male Wistar rats by placing an elastic rubber band under a pressure of 290-310 mmHg on the proximal part of b... | RIP provides effective functional protection and prevents cell injury to gastric tissue induced by limb IR via anti-inflammatory and antioxidant actions. | yes |
25,080,158 | Is increased risk of radiographic emphysema in HIV associated with elevated soluble CD14 and nadir CD4? | {
"contexts": [
"The association between HIV and emphysema remains incompletely understood. We sought to determine whether HIV is an independent risk factor for emphysema severity and whether markers of HIV severity and systemic biomarkers of inflammation (IL-6), altered coagulation (D-dimer), and immune activati... | HIV is an independent risk factor for radiographic emphysema. Emphysema severity was significantly greater among participants with HIV infection. Among those with HIV, nadir CD4 < 200 cells/μL and elevated soluble CD14 level were associated with emphysema, highlighting potential mechanisms linking HIV with emphysema. | yes |
25,081,900 | Does prevalence and correlate of unmet supportive care needs in patients with resected invasive cutaneous melanoma? | {
"contexts": [
"Knowledge about supportive care needs in patients with cutaneous invasive melanoma is scarce. We examined the unmet needs of melanoma patients treated with surgery and factors associated with these needs to assist health professionals identify areas needing clinical attention.",
"Cross-sectio... | Around a quarter of melanoma patients may have unmet support needs in the mid to long term after primary treatment. In particular, patients who are younger, less educated, distressed or socially isolated could benefit from more support. | yes |
25,084,611 | Does dosimetric Inhomogeneity predict for Long-Term Breast Pain After Breast-Conserving Therapy? | {
"contexts": [
"The objective of this cross-sectional study was to characterize long-term breast pain in patients undergoing breast-conserving surgery and radiation (BCT) and to identify predictors of this pain.",
"We identified 355 eligible patients with Tis-T2N0M0 breast cancer who underwent BCT in 2007 to... | Long-term breast pain was common after BCT. Although nearly half of patients had pain, most considered it tolerable. Dosimetric inhomogeneity independently predicted for pain and should be minimized to the greatest extent possible. | yes |
25,069,814 | Does short-term venous stasis induce fibrinolytic activation but not thrombin formation? | {
"contexts": [
"Venous stasis is a well-known risk factor for the development of venous thromboembolism. It is likely that stasis increases the risk of thrombosis by inducing hypercoagulability via the hypoxic procoagulant activation of endothelial and mononuclear cells and the accumulation of activated clotting... | We conclude that short-term venous stasis induces a profibrinolytic response due to the activation of endothelial cells, but not a prothrombotic response, even in the presence of additional thrombophilic risk factors. Furthermore, our results support the hypothesis that the stasis-induced profibrinolytic activation of ... | yes |
25,069,812 | Is carotid artery stenosis exacerbated in spontaneously obese model rats with diabetes? | {
"contexts": [
"Population studies have shown obesity and diabetes to be risk factors for atherosclerosis. We assessed changes in the common carotid arteries in rat models of obesity and diabetes without hypertension.",
"Twenty 30-week-old male spontaneously diabetic and obese model Otsuka Long-Evans Tokushi... | The OLETF rats were obese, and diabetes worsened the degree of carotid artery stenosis. These results indicate the possibility of new therapies for carotid artery stenosis in obese and diabetic patients. | yes |
25,084,811 | Do silent polymorphisms in the RYR1 gene modify the phenotype of the p.4898 I > T pathogenic mutation in central core disease : a case report? | {
"contexts": [
"Central core disease is a congenital myopathy, characterized by presence of central core-like areas in muscle fibers. Patients have mild or moderate weakness, hypotonia and motor developmental delay. The disease is caused by mutations in the human ryanodine receptor gene (RYR1), which encodes a c... | Considering that patient's relatives showed no pathologic phenotype, and the phenotype presented by the patient is within the range observed in other central core disease patients with the same mutation, it was concluded that the c.14256 A > C polymorphism alone is not responsible for disease, and the associated additi... | no |
25,096,710 | Are flavones from Erythrina falcata modulators of fear memory? | {
"contexts": [
"Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide such beneficial effects on memory. The aim of this study was to identify the flavonoid... | Our results demonstrate that vitexin, isovitexin and diosmetin-6-C-glucoside and flavonoidic fractions resulted in a significant retention of fear memory but did not prevent the extinction of fear memory. These results further substantiate that the treatment with pure flavonoids or flavanoid-rich fractions might repres... | yes |
25,093,290 | Is wee1 a novel independent prognostic marker of poor survival in post-chemotherapy ovarian carcinoma effusions? | {
"contexts": [
"Wee1-like kinase (Wee1) is a tyrosine kinase which negatively regulates entry into mitosis at the G2 to M-phase transition and has a role in inhibition of unscheduled DNA replication in S-phase. The present study investigated the clinical role of Wee1 in advanced-stage (FIGO III-IV) ovarian serou... | Wee1 is frequently expressed in ovarian serous carcinoma effusions, and its expression is significantly higher following exposure to chemotherapy. The present study is the first to report that Wee1 is an independent prognostic marker in serous ovarian carcinoma. | yes |
25,083,879 | Does carvacrol alleviate ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats? | {
"contexts": [
"Liver ischemia reperfusion (I/R) injury is a common pathophysiological process in many clinical settings. Carvacrol, a food additive commonly used in essential oils, has displayed antimicrobials, antitumor and antidepressant-like activities. In the present study, we investigated the protective ef... | The results suggest that carvacrol could alleviate I/R-induced liver injury by its anti-oxidative and anti-apoptotic activities, and warrant a further investigation for using carvacrol to protect I/R injury in clinic. | yes |
25,083,878 | Does chikungunya virus exploit miR-146a to regulate NF-κB pathway in human synovial fibroblasts? | {
"contexts": [
"Chikungunya virus causes chronic infection with manifestations of joint pain. Human synovial fibroblasts get infected with CHIKV and could lead to pro-inflammatory responses. MicroRNAs have potentials to regulate the gene expression of various anti-viral and pro-inflammatory genes. The study aims... | This study demonstrated the mechanism of exploitation of cellular miR-146a by CHIKV in modulating the host antiviral immune response in primary human synovial fibroblasts. | yes |
25,076,913 | Do functional crosstalk between the mitochondrial PTP and KATP channels determine arrhythmic vulnerability to oxidative stress? | {
"contexts": [
"Mitochondrial permeability transition pore (mPTP) opening is a terminal event leading to mitochondrial dysfunction and cell death under conditions of oxidative stress (OS). However, mPTP blockade with cyclosporine A (CsA) has shown variable efficacy in limiting post-ischemic dysfunction and arrhy... | Cardioprotection by CsA requires mKATP channel activation through a PKC-dependent pathway. Increasing mKATP activity during CsA administration is required for limiting OS-induced electrical dysfunction. | yes |
25,098,205 | Are proliferation and differentiation of human adipose-derived mesenchymal stem cells ( ASCs ) into osteoblastic lineage passage dependent? | {
"contexts": [
"The effect of in vitro expansion of human adipose-derived stem cells (ASCs) on stem cell properties is controversial. We examined serial subcultivation with expansion on the ability of ASCs to grow and differentiate into osteoblastic lineages.",
"Flow cytometric analysis, growth kinetics, cel... | Osteogenic potential of ASCs is impaired by successive passaging and may not serve as a useful clinical source of osteogenic ASCs past P2. | yes |
25,072,499 | Is serotonin 5-HT7 receptor critically involved in acute and chronic inflammation of the gastrointestinal tract? | {
"contexts": [
"Intestinal inflammation is often associated with an increased level of serotonin (5-HT), an important gastrointestinal signaling molecule involved in gut homeostasis through stimulation of specific receptors. In this study, we investigated the role of 5-HT7 receptor (5-HT7R) in the induction and ... | The 5-HT7R expressed on CD11c/CD86-positive myeloid cells modulates the severity of intestinal inflammation in an acute and chronic colitis and thus represents a potential therapeutic target for the treatment of inflammatory disorders such as CD. | yes |
25,080,971 | Does integration of proteomic and transcriptomic profiles identify a novel PDGF-MYC network in human smooth muscle cells? | {
"contexts": [
"Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cells that characterize physiologic and pathologic tissue remodeling in hollow organs. However, neither the molecular basis of PDGFR-regulated signaling webs, ... | These findings provide the first systems-level analysis of the PDGF-regulated transcriptome and proteome in normal smooth muscle cells. The analyses revealed an extensive cohort of PDGF-dependent biological processes and connected key transcriptional effectors to their regulation, significantly expanding current knowle... | yes |
25,078,873 | Is optimal dairy intake predicated on total , cardiovascular , and stroke mortalities in a Taiwanese cohort? | {
"contexts": [
"Dairy foods help achieve essential nutrient adequacy. This role may be conflicted where so-called chronic diseases prevail. We have examined associations between dairy intake and mortality where dairy foods have not been traditional.",
"A representative Taiwanese cohort of 3810 subjects, aged... | In a Chinese food culture, a dairy foods intake in adults up to 7 times a week does not increase mortality and may have favorable effects on stroke. | yes |
25,077,931 | Does intraoperative 3-D imaging improve sentinel lymph node biopsy in oral cancer? | {
"contexts": [
"The aim of this study was to prospectively evaluate the feasibility and potential advantages of freehand single-photon emission computed tomography (fhSPECT) compared with conventional intraoperative localization techniques for sentinel lymph node biopsy (SLNB) in oral cancer.",
"Between Nove... | FhSPECT is a feasible technology that allows the accurate identification of SLNs in oral cancer. FhSPECT overcomes the shine-through phenomenon, one of the most important limitations of SLNB, thereby confirming the importance of SLNB in patients with cN0 oral cancer. | yes |
25,082,957 | Is robot-assisted gait training superior to balance training for improving postural instability in patients with mild to moderate Parkinson 's disease : a single-blind randomized controlled trial? | {
"contexts": [
"The main aim was to compare robotic gait training vs. balance training for reducing postural instability in patients with Parkinson's disease. The secondary aim was to compare their effects on the level of confidence during activities of daily living requiring balance, functional mobility and sev... | Our findings indicate that robotic gait training is not superior to balance training for improving postural instability in patients with mild to moderate Parkinson's disease. | no |
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