pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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27,497,671 | Does n-Acetylcysteine Amide exert Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia? | {
"contexts": [
"Perinatal asphyxia and ensuing reoxygenation change the antioxidant capacity of cells and organs.",
"To analyze the neuroprotective effect of the antioxidant N-acetylcysteine amide (NACA) after perinatal hypoxia-reoxygenation with an emphasis on proinflammatory cytokines and the transcription... | The reduced levels of the pivotal inflammatory markers IL-1β and TNFα and the transcription factor NF-x03BA;B may indicate that NACA has possible neuroprotective effects after perinatal asphyxia. | yes |
27,496,986 | Does coaching of patients with an isolated minimally displaced fracture of the radial head immediately increase range of motion? | {
"contexts": [
"Prospective cohort.",
"Elbow stiffness is the most common adverse event after isolated radial head fractures.",
"To assess the effect of coaching on elbow motion during the same office visit in patients with such fractures.",
"We enrolled 49 adult patients with minimally displaced rad... | Instruction that stretching exercises are healthy even when painful resulted in immediate improvements in motion. Prospective studies comparing different strategies for coaching patients regarding painful stretches might help clarify the optimal approach. | yes |
27,513,384 | Do higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human Papillomavirus Clearance in Uncircumcised Kenyan Men? | {
"contexts": [
"Whether higher penile human papillomavirus (HPV) viral load is associated with a lower rate of HPV clearance remains unknown.",
"We examined the association between penile HPV16 and HPV18 viral load and subsequent HPV clearance in uncircumcised Kenyan men.",
"Participants were human immun... | High versus low HPV viral load was associated with a reduced HPV clearance for HPV16 infections in the glans and shaft, and for HPV18 infections in the glans, among young uncircumcised men. Reduced clearance of high viral load HPV16 and HPV18 infections in men may increase HPV transmission to their female partners as w... | yes |
27,489,205 | Is aRT an alternative for restoring occlusoproximal cavities in primary teeth - evidence from an updated systematic review and meta-analysis? | {
"contexts": [
"A previous systematic review showed that atraumatic restorative treatment (ART) can be an option to restore the occlusoproximal cavities in primary teeth; however, few studies fulfilled the criteria of inclusion to generate a high level of evidence.",
"To update the existing systematic review... | ART restorations have similar survival rate compared to conventional treatment and can be considered an option to restore occlusoproximal cavities in primary molars. | yes |
27,493,271 | Does tERT promoter mutation predict radioiodine refractory in distant metastatic differentiated thyroid cancer? | {
"contexts": [
"Telomerase Reverse Transcriptase (TERT) promoter mutation has been reported to be associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study examined the status of TERT promoter mutation in distant metastatic DTC (DM-DTC), and evaluated the correlation between T... | TERT promoter mutation closely associates with non-RAI-avidity in DM-DTC, and when comparing with BRAF mutation, TERT mutation manifested a worse negative influence on RAI uptake. It could also be used as a predictive marker to early identify refractory to RAI. | yes |
27,493,886 | Does serum Thyroglobulin Concentration be a Weak Marker of Iodine Status in a Pregnant Population with Iodine Deficiency? | {
"contexts": [
"To assess the reliability of thyroglobulin (Tg) as a marker of iodine status during pregnancy.",
"299 women aged 30.5 ± 4.8 years (mean ± SD) were studied.",
"In every subject, we measured urinary iodine concentration (UIC), serum thyrotropin (TSH), Tg, free thyroxine (fT4), Tg autoantibo... | Tg cannot be considered as a valid marker of iodine deficiency in pregnancy, at least in a mildly iodine-deficient environment. Further studies in a larger patient cohort with differences in iodine status, as well as studies on Tg changes after improving iodine status in pregnant women, are needed in order to corrobora... | yes |
27,493,882 | Is familiar Papillary Thyroid Carcinoma in a Large Brazilian Family Associated with Succinate Dehydrogenase Defects? | {
"contexts": [
"Thyroid cancer is the most common endocrine gland malignancy. Advances in understanding the genetic basis for thyroid cancer revealed the potential involvement of several genes in the formation of thyroid tumors. Mutations in the gene coding for succinate dehydrogenase subtype B (SDHB) have been ... | Familiar PTC and a GIST were not associated with SDHx mutations; additional genetic defects, yet unknown, may be responsible for the development of tumor. | no |
27,497,058 | Does valve interstitial cell tensional homeostasis direct calcification and extracellular matrix remodeling processes via RhoA signaling? | {
"contexts": [
"Valve interstitial cells are active and aggressive players in aortic valve calcification, but their dynamic mediation of mechanically-induced calcific remodeling is not well understood. The goal of this study was to elucidate the feedback loop between valve interstitial cell and calcification mec... | Interstitial cell contractility mediates internal stress state and organization of the aortic valve extracellular matrix. Osteogenesis disrupts interstitial cell mechanical phenotype and drives disorganization, nodule formation, and pro-calcific signaling via a RhoA-dependent mechanism. | yes |
27,512,726 | Does 2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibit LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways? | {
"contexts": [
"To verify the effects of several 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) derivatives on LPS-induced NO production, cellular ROS levels and cytokine expression in BV-2 microglial cells.",
"An MTT assay and FACS flow cytometry were performed to assess the cellular viability and apoptosis and ce... | Our findings demonstrate that our newly synthesized compound derived from DMNQ, 2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone (R6), might be a therapeutic agent for the treatment of glia-mediated neuroinflammatory diseases. | yes |
27,491,044 | Does cLOSING MACULAR hole WITH `` MACULAR PLUG '' WITHOUT GAS TAMPONADE AND POSTOPERATIVE POSTURING? | {
"contexts": [
"To investigate the surgical results of macular hole surgery without gas tamponade or postoperative posturing in patients with Stage 3 and Stage 4 macular holes with ≥500 μm mean base diameter.",
"Retrospective interventional case series.",
"Twenty-six patients with Stage 3 and Stage 4 mac... | Twenty-three-gauge pars plana vitrectomy combined with broad ILM peeling, use of ILMR and autologous gluconated blood clumps as a macular plug is effective in achieving satisfactory hole closure with statically significant functional improvement for large Stage 3 and Stage 4 macular holes. | yes |
27,497,609 | Is palmitate-Induced MMP-9 Expression in the Human Monocytic Cells Mediated through the TLR4-MyD88 Dependent Mechanism? | {
"contexts": [
"Obese individuals are known to have increased Matrix metalloproteinase (MMP)-9 plasma levels and MMP-9 is reported to play an important role in obesity-associated adipose tissue inflammation. Since in obesity, the levels of circulatory saturated free fatty acid (FFA) palmitate (palimitic acid) ar... | Altogether, these results show that palmitate induces TLR4-dependent activation of MMP-9 gene expression, which requires the recruitment of MyD88 leading to activation of NF-kB/AP-1 transcription factors. Thus, our findings suggest that the palmitate-induced MMP-9 secretion might be an underlying mechanism of its incre... | yes |
27,504,496 | Does trans-pQTL study identify immune crosstalk between Parkinson and Alzheimer loci? | {
"contexts": [
"Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility variants influenced protein expression of well-established AD-associated myeloid genes in... | We find that the rs12456492 PD risk variant affects expression of AD-associated protein CD33 in peripheral monocytes, which suggests that genetic factors for these 2 diseases may converge to influence overlapping innate immune-mediated mechanisms that contribute to neurodegeneration. Furthermore, the effect of the rs12... | yes |
27,501,951 | Does cytosolic phospholipase A2 contribute to innate immune defense against Candida albicans lung infection? | {
"contexts": [
"The lung is exposed to airborne fungal spores, and fungi that colonize the oral cavity such as Candida albicans, but does not develop disease to opportunistic fungal pathogens unless the immune system is compromised. The Group IVA cytosolic phospholipase A2 (cPLA2α) is activated in response to Ca... | The results demonstrate that cPLA2α contributes to immune surveillance and host defense in the lung to prevent infection by the commensal fungus C. albicans and to dampen inflammation. | yes |
27,501,956 | Is the leishmanicidal activity of oleuropein selectively regulated through inflammation- and oxidative stress-related genes? | {
"contexts": [
"Much research effort has been focused on investigating new compounds derived from low-cost sources, such as natural products, for treating leishmaniasis. Oleuropein derived from numerous plants, particularly from the olive tree, Olea europaea L. (Oleaceae), is a biophenol with many biological act... | The ability of Oleuropein to promote a Th1 type immune response in L. donovani-infected BALB/c mice points towards the candidacy of this bioactive compound as an immunomodulatory agent that may complement therapeutic approaches to leishmaniasis. | yes |
27,493,455 | Does addition of Dexamethasone alter the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes? | {
"contexts": [
"Primary human hepatocytes offer the best human in vitro model for studies on human liver cell metabolism. Investigators use a variety of different media supplements and matrix biocoatings and the type of culture system used may influence the outcome.",
"To optimize in vitro conditions for pri... | Primary human hepatocytes have an increased bile acid synthesis rate when cultured on matrigel as compared to collagen. Exposure to glucocorticoid hormones stimulates the expression of CYP8B1, leading to an increased formation of CA and alteration of the bile acid composition. The effect is most likely mediated through... | yes |
27,492,328 | Does benzoate fraction from Gentiana rigescens Franch alleviate scopolamine-induced impaired memory in mice model in vivo? | {
"contexts": [
"G. rigescens Franch (Long Dan Cao in Chinese) is a well-known TCM herb. It is clinically used with other drugs for the treatment of brain diseases such as epilepsy, postherpetic neuralgia in China.",
"In our previous study, the 11 dihydroxybenzoates compounds with NGF mimicking activity from ... | n-GS could alleviate impaired memory of the SCO-induced mice model by inhibiting AChE activity and oxidative stress, and regulating the IGF-1R/ERK signaling pathway. | yes |
27,495,873 | Does silencing Drp1 inhibit glioma cells proliferation and invasion by RHOA/ ROCK1 pathway? | {
"contexts": [
"Dynamin-related protein 1 (Drp1) is a newly discovered therapeutic target for tumor initiation, migration, proliferation, and chemosensitivity. In the present study, we aimed to examine the level of expression and distribution of DRP1 in glioma tissues and explore the concrete mechanism of DRP1 p... | Our results demonstrated that silencing DRP1 regulated the cytoskeleton remodeling through inhibiting RHOA/ROCK1 pathway, and thus decreased the proliferation and invasion of glioma cells. | yes |
27,492,993 | Does specific locations of linear furrow in patients with esophageal eosinophilia? | {
"contexts": [
"Linear furrows are the most frequently found endoscopic abnormality in patients with esophageal eosinophilia (EE); however, the precise endoscopic features remain to be fully elucidated. Here, we aimed to clarify the endoscopic features of EE, essential for the diagnosis of eosinophilic esophagit... | Investigation of these endoscopic characteristics, especially by focusing on linear furrows in esophageal mucosal fold valleys, may provide important clues for more accurate diagnosis of EoE. | yes |
27,494,777 | Does early remission status predict long-term outcomes in patients with Crohn 's disease treated with certolizumab pegol? | {
"contexts": [
"In Crohn's disease (CD), rapid response to anti-tumor necrosis factor therapy improves short- and medium-term outcomes, but the relationship between early remission (ER) and long-term remission is unclear.",
"This exploratory analysis of PRECiSE 3 (NCT00160524) assessed whether ER after initi... | In certolizumab pegol-treated patients with CD, ER appears to be an important predictor of long-term clinical remission. Prospective trials are needed to determine whether ER improves other long-term outcomes. | yes |
27,497,085 | Do distinct resting-state perfusion patterns underlie psychomotor retardation in unipolar vs. bipolar depression? | {
"contexts": [
"Psychomotor abnormalities characterize both unipolar (UP) depression and bipolar (BP) depression. We aimed to assess their neurobiological correlates in terms of motor activity (AL) and resting-state cerebral blood flow (rCBF) and investigate their association in BP, UP, and healthy controls (HC)... | The differences in rCBF and in the localization of the clusters of positive AL/rCBF correlations between BP and UP suggest that different neural impairments may underlie motor symptoms in the two disorders, but finally converge in phenotypically similar manifestations. | yes |
27,507,241 | Do cpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells? | {
"contexts": [
"Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression in the le... | The evidence presented suggests that the methylation of the CpG sites of the CRYAA promotor directly affect Sp1 binding, leading to down expression of CRYAA in human lens epithelial cells. Zebularine treatment could restore CRYAA expression in a dose- dependent and time- dependent pattern. | yes |
27,514,646 | Does microRNA-34b mediate hippocampal astrocyte apoptosis in a rat model of recurrent seizures? | {
"contexts": [
"Recurrent convulsions can cause irreversible astrocyte death, impede neuron regeneration, and further aggravate brain damage. MicroRNAs have been revealed as players in the progression of numerous diseases including cancer and Alzheimer's disease. Particularly, microRNA has been found linked to s... | Our findings prove microRNAs play a role in mediating recurrent convulsions-induced astrocyte death and further indicate that miR-34b-5p could acts as a regulator for astrocyte apoptosis induced by recurrent seizures. | yes |
27,498,776 | Is the POR rs1057868-rs2868177 GC-GT diplotype associated with high tacrolimus concentrations in early post-renal transplant recipients? | {
"contexts": [
"Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes (CYP), and several POR SNPs have been shown to be important contributors to altered CYP activity or CYP-mediated drug metabolism. In this study we examined the association between 6... | The CYP3A5*3 and POR rs1057868-rs2868177 GC-GT diplotype accounted for the inter-individual variation of tacrolimus C0D7/D. Genotyping of POR rs1057868-rs2868177 diplotypes would help to differentiate initial tacrolimus dose requirements and to achieve early target C0 ranges in Chinese renal transplant recipients. | yes |
27,498,779 | Does sweroside ameliorate α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses? | {
"contexts": [
"Sweroside is an iridoid glycoside with diverse biological activities. In the present study we investigated the effects of sweroside on α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury in mice.",
"Mice received sweroside (120 mg·kg(-1)·d(-1), ig) or a positive control INT-747 (... | Sweroside attenuates ANIT-induced cholestatic liver injury in mice by restoring bile acid synthesis and transport to their normal levels, as well as suppressing pro-inflammatory responses. | yes |
27,505,217 | Is snack intake reduced using an implicit , high-level construal cue? | {
"contexts": [
"Priming a high level construal has been shown to enhance self-control and reduce preference for indulgent food. Subtle visual cues have been shown to enhance the effects of a priming procedure. The current study therefore examined the combined impact of construal level and a visual cue reminder o... | Priming high construal level thinking reduces consumption of high energy dense snacks in the presence of a visual cue-reminder. This may be a practical technique for reducing overeating and has the potential to be extended to other unhealthy behaviors. (PsycINFO Database Record | yes |
27,517,839 | Is pTEN loss associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma? | {
"contexts": [
"Although trastuzumab improves the outcome of patients with human epidermal growth factor receptor 2 (HER2)-overexpressing gastric or gastroesophageal junction adenocarcinoma (collectively referred to as \"gastroesophageal adenocarcinoma\"; GEA), no clinical response is observed in a substantial p... | PTEN loss was frequently found in HER2-overexpressing tumors, and was associated with a poor response to trastuzumab-based therapy in patients with GEA. | yes |
27,501,701 | Does orthogeriatric co-management improve the outcome of long-term care residents with fragility fractures? | {
"contexts": [
"Fragility fractures are a major health care problem worldwide. Both hip and non-hip fractures are associated with excess mortality in the years following the fracture. Residents of long-term nursing homes represent a special high-risk group for poor outcomes. Orthogeriatric co-management models o... | Despite the generally poor outcomes for fragility fracture patients residing in long-term care facilities, orthogeriatric co-management appears to improve the outcome of high-risk fragility fracture patients. One-year mortality was 29.4 % in this cohort, significantly lower than in comparable trials. Orthogeriatric co-... | yes |
27,495,286 | Does lipid Emulsion Formulation of Parenteral Nutrition affect Intestinal Microbiota and Host Responses in Neonatal Piglets? | {
"contexts": [
"Total parenteral nutrition (TPN) is a cause of intestinal microbial dysbiosis and impaired gut barrier function. This may contribute to life-threatening parenteral nutrition-associated liver disease and sepsis in infants. We compared the effects of a lipid emulsion containing long-chain ω-3 polyu... | The formulation of parenteral lipid is associated with differences in the gut microbiota and host response of TPN-fed neonatal piglets. Inclusion of ω-3 long-chain PUFAs appears to improve host-microbial interactions at the mucosal surface, although mechanisms are yet to be defined. | yes |
27,513,882 | Does thrombomodulin enhance complement regulation through strong affinity interactions with factor H and C3b-Factor H complex? | {
"contexts": [
"Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b. Thrombomodulin (TM) is a cell-bound regulator of thrombin activation, but can also enhance the regulatory activity of complement factor H (FH), thus... | TM exhibits significant binding affinity for complement protein FH and C3b-FH complex and its soluble form is capable at physiologically relevant concentrations of inhibiting complement activation in serum. | yes |
27,503,167 | Do development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican? | {
"contexts": [
"There are many patients that exhibit connective tissue related cardiac malformations but do not have mutations in collagen genes. The Small Leucine Rich Proteoglycans (SLRP) fibromodulin (FMOD) and lumican (LUM) bind collagen and regulate fibril assembly in other biological contexts.",
"FMOD ... | The postnatal assembly of the collagen-rich ECM in regions where cardiac valves anchor, that we have designated 'myotendinous-like junctions' (MTLJ) requires the SLRPs FMOD and LUM. Moreover, FMOD and LUM may facilitate mesenchymal cell differentiation in late stages of cardiac valve development. Developmental Dynamics... | yes |
27,504,739 | Is methylglyoxal associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus? | {
"contexts": [
"The glycolysis-derived metabolite methylglyoxal has been linked to clinical microvascular complications, including diabetic nephropathy. We aimed to further investigate the hypothesis that methylglyoxal is involved in decline in renal function by assessing the associations between measures of ren... | In a population of people with screen-detected Type 2 diabetes, we observed associations between methylglyoxal and markers of renal function: 6-year change in methylglyoxal was inversely associated with 6-year change in eGFR. Also, methylglyoxal at baseline was positively associated with ACR at baseline. Our study lend... | yes |
27,504,737 | Is the induction of CXCR4 expression in human osteoblast-like cells ( MG63 ) by CoCr particles regulated by the PLC-DAG-PKC pathway? | {
"contexts": [
"Osteolysis which leads to aseptic loosening of implants is a fundamental problem in joint replacement surgery (arthroplasty) and the leading cause for implant failure and revision surgery. Metal (CoCr) particles separated from implants by wear cause osteolysis and the failure of orthopedic implan... | The induction of CXCR4-specific mRNA expression in MG63 cells after stimulation with CoCr particles is regulated by the PLC-DAG-PKC pathway and not by the MAPK/ERK pathway. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016. | yes |
27,518,593 | Does histological examination confirm clinical clearance of actinic keratoses following treatment with ingenol mebutate 0·05 % gel? | {
"contexts": [
"To date, studies with ingenol mebutate gel have used clinical clearance, not histological clearance, as a primary efficacy endpoint.",
"This phase I, multicentre, single-arm, open-label study sought to confirm histologically the clinical clearance of actinic keratoses (AKs) to support a treat... | Ingenol mebutate achieves histopathological clearance of AKs that correlates with observed clinical clearance. Clinical clearance is a good predictor for histological clearance. | yes |
27,512,981 | Is acid Sphingomyelinase ( ASM ) a Negative Regulator of Regulatory T Cell ( Treg ) Development? | {
"contexts": [
"Regulatory T cell (Treg) is required for the maintenance of tolerance to various tissue antigens and to protect the host from autoimmune disorders. However, Treg may, indirectly, support cancer progression and bacterial infections. Therefore, a balance of Treg function is pivotal for adequate imm... | ASM is a negative regulator of natural and iTreg. | yes |
27,506,670 | Does selective use of the intra-aortic filter in high-risk cardiac surgical patients lead to better postoperative outcomes? | {
"contexts": [
"The objective of this study was to evaluate the effect of an intra-aortic filter on postoperative outcomes in high-risk cardiac surgical patients.",
"An intra-aortic filter was used in 316 (4.9%) of 6442 cardiac surgical cases from 2003 to 2013. A retrospective analysis of the Society of Thor... | The use of the intra-aortic filter reduces postoperative complications after cardiac surgery and should be considered for use in high-risk cases. | yes |
27,495,374 | Do cUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment? | {
"contexts": [
"While localized malignancies often respond to available therapies, most disseminated cancers are refractory. Novel approaches, therefore, are needed for the treatment of metastatic disease. CUB domain-containing protein1 (CDCP1) plays an important role in metastasis and drug resistance; the mecha... | Together, these results suggest that CDCP1 may facilitate loss of adhesion by promoting activation of EGFR and Src at sites of cell-cell and cell-substratum contact. | yes |
27,493,725 | Do essential amino acid ratios and mTOR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells? | {
"contexts": [
"The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells.",
"Triplicate cultures with the respective \"optimal\" amino acid (AA) ratio (OPAA = Lys... | The observed up-regulation of lipogenic gene networks and the changes in expression of key miRNA involved in the control of lipogenic balance are indicative of a potentially important role of EAA ratios and mTOR signaling in the regulation of milk fat synthesis. | yes |
27,514,407 | Does transcription Factor KLF5 bound a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk? | {
"contexts": [
"It is well established that environmental toxins, such as exposure to arsenic, are risk factors in the development of urinary bladder cancer, yet recent genome-wide association studies (GWAS) provide compelling evidence that there is a strong genetic component associated with disease predispositi... | A polymorphic KLF5 binding site near the CCNE1 gene explains genetic risk identified through GWAS. Mol Cancer Res; 14(11); 1078-86. ©2016 AACR. | yes |
27,509,223 | Does cXCL13 inhibit microRNA-23a through PI3K/AKT signaling pathway in adipose tissue derived-mesenchymal stem cells? | {
"contexts": [
"Adipose tissue derived-mesenchymal stem cells (AMSCs) are one of the most widely used MSCs in the cell therapy for regenerative medicine. In the current study, the role of CXCL13 in AMSCs and its potential signaling pathway were investigated.",
"AMSCs were isolated from adipose tissue of heal... | CXCL13 inhibits miR-23a expression through modulating PI3K/AKT pathway in AMSCs. | yes |
27,502,515 | Does a Selective Cell Population From Dermis strengthen Bone Regeneration? | {
"contexts": [
": Finding appropriate seed cells for bone tissue engineering remains a significant challenge. Considering that skin is the largest organ, we hypothesized that human bone morphogenetic protein receptor type IB (BmprIB)+ dermal cells could have enhanced osteogenic capacity in the healing of critica... | Dermal cells are a promising cell population for bone regeneration; unfortunately, the osteogenic potential of unsorted cells was quite low. This study demonstrated that a specific cell population in human dermis-bone morphogenetic protein receptor IB (BmprIB)+ cells-exhibited significantly higher osteogenic potential ... | yes |
27,505,209 | Do smokers exhibit biased neural processing of smoking and affective images? | {
"contexts": [
"There has been growing interest in the role that implicit processing of drug cues can play in motivating drug use behavior. However, the extent to which drug cue processing biases relate to the processing biases exhibited to other types of evocative stimuli is largely unknown. The goal of the pre... | Results suggest that cognitive biases may extend across classes of stimuli among smokers. This raises important questions about the fundamental meaning of cognitive biases, and suggests the need to consider generalized cognitive biases in theories of drug use behavior and interventions based on cognitive bias modificat... | yes |
27,505,202 | Are self-reported and automatic cognitions associated with exercise behavior in cancer survivors? | {
"contexts": [
"Physical activity is beneficial for cancer survivors, but exercise participation is low in this population. It is therefore important to understand the psychological factors underlying exercise uptake so that more effective interventions can be developed. Social-cognitive theory constructs such a... | Both self-reported cognitions and implicit cognitions may be useful to identify individuals at risk of failing to exercise. Individuals so identified might be provided with a different or more intensive intervention. The data also suggest cognitive targets for intervention. (PsycINFO Database Record | yes |
27,514,986 | Does global transcriptional analysis suggest Lasiodiplodia theobromae pathogenicity factors involved in modulation of grapevine defensive response? | {
"contexts": [
"Lasiodiplodia theobromae is a fungus of the Botryosphaeriaceae that causes grapevine vascular disease, especially in regions with hot climates. Fungi in this group often remain latent within their host and become virulent under abiotic stress. Transcriptional regulation analysis of L. theobromae ... | L. theobromae transcriptome was established and validated. Its usefulness was demonstrated through the identification of genes expressed during the infection process. Our results support the hypothesis that heat stress facilitates fungal colonization, because of the fungus ability to use the phenylpropanoid precursors ... | yes |
27,506,406 | Are differences in dural penetration of clival chordomas associated with different prognosis and expression of platelet-derived growth factor receptor-β? | {
"contexts": [
"To compare prognosis of clival chordomas with different dural penetration, and establish the relationship between dural penetration and platelet-derived growth factor receptor (PDGFR)-β signaling pathway.",
"Tumors in Type I (33 cases) showed limited dural penetration, while those in Type II ... | Clival chordomas have different degrees of dural penetration. Patients with chordomas with serious dural penetration have poorer prognosis. Higher expression of PDGFR-β is related to more serious dural penetration of clival chordomas. | yes |
27,489,308 | Are copy-number variations enriched for neurodevelopmental genes in children with developmental coordination disorder? | {
"contexts": [
"Developmental coordination disorder is a common neurodevelopment disorder that frequently co-occurs with other neurodevelopmental disorders including attention-deficit hyperactivity disorder (ADHD). Copy-number variations (CNVs) have been implicated in a number of neurodevelopmental and psychiatr... | These findings suggest that there may be shared susceptibility genes for DCD and other neurodevelopmental disorders and highlight the need for thorough phenotyping when investigating the genetics of neurodevelopmental disorders. Furthermore, these data provide compelling evidence supporting a genetic basis for DCD, and... | yes |
27,517,349 | Do spontaneous ripples in the hippocampus correlate with epileptogenicity and not memory function in patients with refractory epilepsy? | {
"contexts": [
"High-frequency oscillations (HFOs, 80-500Hz) are newly-described EEG markers of epileptogenicity. The proportion of physiological and pathological HFOs is unclear, as frequency analysis is insufficient for separating the two types of events. For instance, ripples (80-250Hz) also occur physiologic... | Our results suggest that the majority of spontaneous hippocampal ripples, as defined in the present study, may reflect pathological activity, taking into account the association with memory impairment. The absence of negative correlation between memory performance and HFO rates in seizure onset areas could be explained... | yes |
27,497,962 | Does mineralocorticoid Receptor Blockade improve Insulin Sensitivity in the Rat Heart and a Possible Molecular Mechanism? | {
"contexts": [
"Extensive research has explored the role of aldosterone in insulin resistance. Recent evidence suggests that the mineralocorticoid receptor (MR) mediates aldosterone-induced dysregulation of cytokines, and most of this research has focused on adjustments in fat tissue and adipocytes. However, the... | The above results suggested that aldosterone promoted insulin resistance in the heart and that this effect could be partly reversed by MR blockade through signal transduction in the P38 MAPK pathway and PPARα. | yes |
27,507,659 | Do birth order and hospitalization for alcohol and narcotics use in Sweden? | {
"contexts": [
"Previous studies have shown that birth order is an important predictor of later life health as well as socioeconomic attainment. In this study, we examine the relationship between birth order and hospitalization for alcohol and narcotics use in Sweden.",
"We study the relationship between bir... | Later born siblings are more likely to be hospitalized for both alcohol and narcotics use in Sweden. These birth order effects are substantial in size, and larger than the estimated sex differences for the risk of hospitalization related to alcohol and drug use before age 20, and previous estimates for socioeconomic st... | yes |
27,517,064 | Is discrete Pathophysiology Uncommon in Patients with Nonspecific Arm Pain? | {
"contexts": [
"Nonspecific symptoms are common in all areas of medicine. Patients and caregivers can be frustrated when an illness cannot be reduced to a discrete pathophysiological process that corresponds with the symptoms. We therefore asked the following questions: 1) Which demographic factors and psycholog... | Nonspecific diagnoses are not harmful. Prospective randomized research is merited to determine if nonspecific, descriptive diagnoses are better for patients than specific diagnoses that imply pathophysiology in the absence of discrete verifiable pathophysiology. | yes |
27,514,245 | States diet quality , risk factors and access to care among low-income uninsured American adults in states expanding Medicaid vs. expanding under the affordable care act? | {
"contexts": [
"The Affordable Care Act (ACA) Medicaid expansion varies in availability across states.",
"We compared characteristics of low-income uninsured residents in both Medicaid nonexpanding and expanding states with respect to their dietary quality, health risk factors, and access to care.",
"Dat... | Differences across states in Medicaid coverage under the ACA may lead to widening disparities in health outcomes between expanding and non-expanding states. | no |
27,499,636 | Does jAK2 inhibitor combined with DC-activated AFP-specific T-cells enhance antitumor function in a Fas/FasL signal-independent pathway? | {
"contexts": [
"Combination therapy for cancer is more effective than using only standard chemo- or radiotherapy. Our previous results showed that dendritic cell-activated α-fetoprotein (AFP)-specific T-cells inhibit tumor in vitro and in vivo. In this study, we focused on antitumor function of CD8(+) T-cells co... | These results indicate a Fas/FasL-independent pathway for cellular apoptosis in cancer therapies with the treatment of AFP-specific CD8(+) T-cells combined with JAK2 inhibitor. | yes |
27,515,847 | Does intrathecal synthesis of anti-Hu antibodies distinguish patients with paraneoplastic peripheral neuropathy and encephalitis? | {
"contexts": [
"Paraneoplastic syndromes are serious immune caused diseases of the peripheral and/or central nervous system associated with malignant neoplasm. Symptoms develop when antibodies against antigens expressed by tumor cells cross-react with neuronal proteins. Antineuronal antibodies are usually examin... | In conclusion, our results indicate that patients even with one defined antineuronal antibody need to be regarded separately depending on the involved location of the nervous system. We recommend incorporation of anti-Hu analyses in the CSF and calculating the intrathecal synthesis in patients with anti-Hu syndrome. | yes |
27,494,729 | Is an anterior left ventricular lead position associated with increased mortality and non-response in cardiac resynchronization therapy? | {
"contexts": [
"Non-response to cardiac resynchronization therapy (CRT) might be due to insufficient resynchronization as a result of a sub-optimal left ventricular lead positon (LV-LP).",
"To evaluate the impact of different LV-LPs on mortality and symptomatic improvement in a large cohort of patients treat... | An anterior left ventricular lead position is associated with increased all-cause mortality and lower clinical response rate in patients treated with CRT and should be avoided. | yes |
27,489,875 | Are white matter hyperintensities more highly associated with preclinical Alzheimer 's disease than imaging and cognitive markers of neurodegeneration? | {
"contexts": [
"Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and... | WMH volume is more highly associated with preclinical AD than other AD biomarkers. | yes |
27,513,401 | Are plasma lipoprotein ( a ) levels associated with the severity of coronaryheart disease in Han Chinese people? | {
"contexts": [
"The aim of this study was to investigate the association of lipoprotein(a) [Lp(a)] with the severity of coronary heart disease (CHD) in Han Chinese people.",
"Six hundred and seventy-nine patients with angiographically defined CHD were enrolled in this cross-sectional study. Fasting lipids we... | Our data indicate that Lp(a) might be a useful marker in predicting the severity of coronary heart disease. | yes |
27,513,404 | Does rectal or intramuscular diclofenac reduce the incidence of pancreatitis afterendoscopic retrograde cholangiopancreatography? | {
"contexts": [
"Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form.",
"One hundred and fifty consecu... | Prophylaxis with diclofenac given rectally or intramuscularly is an effective option for the management of post-ERCP pancreatitis. | yes |
27,498,289 | Is overexpression of β-Catenin and Cyclin D1 Associated with Poor Overall Survival in Patients with Stage IA-IIA Squamous Cell Lung Cancer Irrespective of Adjuvant Chemotherapy? | {
"contexts": [
"This study was aimed at understanding the effect of β-catenin and cyclin D1 on overall survival in patients with early-stage NSCLC and at evaluating if the prognostic effect can be modified by adjuvant chemotherapy.",
"We retrospectively analyzed the expression of β-catenin and cyclin D1 usin... | The present study suggests that simultaneous overexpression of β-catenin and cyclin D1 may be associated with poor overall survival irrespective of platinum-based adjuvant chemotherapy in stage IA-IIA squamous cell carcinoma of the lung. | yes |
27,515,700 | Does dNA hypomethylation of Synapsin II CpG islands associate with increased gene expression in bipolar disorder and major depression? | {
"contexts": [
"The Synapsins (SYN1, SYN2, and SYN3) are important players in the adult brain, given their involvement in synaptic transmission and plasticity, as well as in the developing brain through roles in axon outgrowth and synaptogenesis. We and others previously reported gene expression dysregulation, b... | These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. | yes |
27,494,342 | Does upright posture improve affect and fatigue in people with depressive symptoms? | {
"contexts": [
"Slumped posture is a diagnostic feature of depression. While research shows upright posture improves self-esteem and mood in healthy samples, little research has investigated this in depressed samples. This study aimed to investigate whether changing posture could reduce negative affect and fatig... | The experiment was only brief and a non-clinical sample was used. | yes |
27,513,084 | Does simvastatin attenuate Acute Lung Injury Via Regulating Cdc42-PAK4 and Endothelial Microparticles? | {
"contexts": [
"Simvastatin has lung vascular-protective effects via augmentation of endothelial barrier function. Accordingly, on the basis of our previous study, we hypothesized that endothelial cell (EC) protection by simvastatin is dependent on the stabilization on cytoskeletons.",
"Sixty C57BL/6 mice we... | An increased serous EMP level associated with Cdc42-PAK4 can be deemed as a useful pulmonary injury marker in LPS-treated mice, and our results might be more relevant in guiding the clinical treatment of ALI by intervening Cdc42-PAK4 or EMPs. | yes |
27,492,279 | Does rpoE promote invasion and intracellular survival by regulating SPI-1 and SPI-2 in Salmonella enterica serovar Typhi? | {
"contexts": [
"To demonstrate the role of RpoE during the later stage of hyperosmotic stress in Salmonella.",
"Expressions of SPI-1 and SPI-2 under hyperosmotic stress for 120 min were investigated by a microarray, and the invasion and intracellular survival of wild-type and ΔrpoE strains were compared. The... | RpoE may promote invasion and intracellular survival by regulating the expression of SPI-1 and SPI-2. | yes |
27,513,713 | Is minor neurological dysfunction in five year old very preterm children associated with lower processing speed? | {
"contexts": [
"Minor neurological dysfunction (MND) is present in one quarter to one third of children born very preterm (VP). The more severe form, complex (c)-MND has been associated with learning disabilities, behavioural and motor problems.",
"To study the association between c-MND and neurocognitive an... | Five year old VP children with c-MND have lower PSQ, slower reaction time, and poorer motor skills, than those without c-MND. Neurological examination should include identification of MND to help identify children at risk for neurocognitive disabilities. | yes |
27,519,859 | Does engineering high Zn in tomato shoot through expression of AtHMA4 involves tissue-specific modification of endogenous genes? | {
"contexts": [
"To increase the Zn level in shoots, AtHMA4 was ectopically expressed in tomato under the constitutive CaMV 35S promoter. However, the Zn concentration in the shoots of transgenic plants failed to increase at all tested Zn levels in the medium. Modification of Zn root/shoot distribution in tomato ... | In transgenic tomato plants, the export activity of ectopically expressed AtHMA4 changes the cellular Zn status, which induces coordinated tissue-specific responses of endogenous ethylene-related genes and metal transporters. These changes constitute an important mechanism involved in the generation of the metal-relate... | yes |
27,511,338 | Is recurrent dilatation in resistant benign esophageal strictures : timing significant? | {
"contexts": [
"Benign esophageal strictures are frequently encountered pathologies occurring due to various reasons. Repeated dilatations may be needed, particularly in resistant strictures. This study aimed to evaluate patients who underwent repeated dilatations in our clinic due to resistant esophageal strict... | Dilatations performed at frequent intervals without waiting for the symptoms of dysphagia can contribute to safer and more effective results in resistant benign esophageal strictures. | yes |
27,511,332 | Is a persistently low HBV DNA level a predictor of spontaneous HBsAg clearance in patients with chronic hepatitis B? | {
"contexts": [
"The incidence and predictors of spontaneous hepatitis B surface-antigen (HBsAg) seroclearance in patients with chronic hepatitis B virus (HBV) were evaluated.",
"A total of 1427 patients with chronic HBV infection, who were followed between 1994 and 2013, were investigated in this retrospecti... | These results suggest that a continuously low viral load is the most important factor affecting spontaneous HBsAg seroclearance. | yes |
27,498,153 | Are verbal memory and search speed in early midlife associated with mortality over 25 years ' follow-up , independently of health status and early life factors : a British birth cohort study? | {
"contexts": [
"Cognitive capabilities in childhood and in late life are inversely associated with mortality rates. However, it is unclear if adult cognition, at a time still relatively free from comorbidity, is associated with subsequent mortality, and whether this explains the associations of early life factor... | Cognitive capability in early midlife was inversely associated with mortality rates over 25 years and accounted for the associations of family background, childhood cognitive ability and educational attainment with mortality. These findings, in a nationally representative cohort with long-term follow-up, suggest that b... | yes |
27,492,962 | Is vonoprazan superior to proton pump inhibitors in healing artificial ulcers of the stomach post-endoscopic submucosal dissection : A propensity score-matching analysis? | {
"contexts": [
"Proton pump inhibitors (PPI) are effective at healing artificial ulcers after endoscopic submucosal dissection (ESD) for gastric neoplasms; however, the efficacy of vonoprazan is not completely understood. The aim of the present study was to determine the healing effect of vonoprazan on artificia... | Vonoprazan has a faster post-gastric ESD artificial ulcer contraction rate than esomeprazole. Vonoprazan may supersede PPI in treating post-ESD artificial ulcers of the stomach. | yes |
27,490,118 | Does hIF-2α Expression regulate Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells? | {
"contexts": [
"During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) regulate the expression of many genes including the potent angiogenesis stimulator VEGF. However, in some pathological conditions chronic hypoxia occurs and is accompanied by reduced angiogenesis.",... | Prolonged culturing of hMVECs at 1% oxygen inhibited endothelial sprouting into fibrin. Two independent mechanisms contribute. Silencing of HIF-2α with si-RNA partially restored the inhibition of endothelial sprouting pointing to a HIF-2α-dependent mechanism. In addition, reduction of uPA contributed to reduced endothe... | yes |
27,490,115 | Is nR5A1 a novel disease gene for 46 , XX testicular and ovotesticular disorders of sex development? | {
"contexts": [
"We aimed to identify the genetic cause in a cohort of 11 unrelated cases and two sisters with 46,XX SRY-negative (ovo)testicular disorders of sex development (DSD).",
"Whole-exome sequencing (n = 9), targeted resequencing (n = 4), and haplotyping were performed. Immunohistochemistry of sex-sp... | We propose NR5A1, previously associated with 46,XY DSD and 46,XX primary ovarian insufficiency, as a novel gene for 46,XX (ovo)testicular DSD. We hypothesize that p.(Arg92Trp) results in decreased inhibition of the male developmental pathway through downregulation of female antitestis genes, thereby tipping the balance... | yes |
27,497,462 | Does the QuickLine IL-6 lateral flow immunoassay improve the rapid intraoperative diagnosis of suspected periprosthetic joint infections? | {
"contexts": [
"When deciding upon the best treatment strategy in revision arthroplasty, it is absolutely crucial to use the best possible preoperative detection whether a periprosthetic joint infection (PJI) is present or not. New molecular markers investigated in serum samples and synovial fluid can help to im... | Taking the limitations of the low sample size as a given this relatively simple point of care (POC) assay showed promising results in our pilot trial and may help diagnosing PJI. It may help physicians and surgeons to choose the best and least invasive treatment strategy for patients presenting with painful arthroplast... | yes |
27,510,741 | Does a Randomized Trial of Expanding Choice set to Motivate Advance Directive Completion? | {
"contexts": [
"Evidence suggests that advance directives may improve end-of-life care among seriously ill patients, but improving completion rates remains a challenge.",
"This study tested the influence of increasing the number of options for completing an advance directive among seriously ill patients.",
... | These results suggest that although an expanded choice set may initially nudge patients toward completing advance directives without restricting choice, increasing actual completion requires additional interventions that overcome downstream barriers. | yes |
27,505,036 | Does race predict the development of metastases in men with nonmetastatic castration-resistant prostate cancer? | {
"contexts": [
"Although race is associated with prostate cancer progression in early stage disease, once men have advanced disease, it is unclear whether race continues to predict a poor outcome. The authors hypothesized that, in an equal-access setting among patients with castration-resistant prostate cancer (... | The lack of racial differences in the development of metastases and scanning practices observed in this study suggests that, once men have a diagnosis of M0/Mx CRPC, race may not be a prognostic factor. Efforts to understand prostate cancer racial disparities may derive greater benefit by focusing on the risk of develo... | no |
27,490,461 | Does dyschloremia be a Risk Factor for the Development of Acute Kidney Injury in Critically Ill Patients? | {
"contexts": [
"Dyschloremia is common in critically ill patients, although its impact has not been well studied. We investigated the epidemiology of dyschloremia and its associations with the incidence of acute kidney injury and other intensive care unit outcomes.",
"This is a single-center, retrospective c... | Dyschloremia is common in critically ill patients, and severe hypochloremia is independently associated with an increased risk of development of acute kidney injury. | yes |
27,503,022 | Does ginsenoside Rd attenuate DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia? | {
"contexts": [
"Ginsenoside Rd (GSRd), one of the main active ingredients in traditional Chinese herbal Panax ginseng, has been found to have therapeutic effects on ischemic stroke. However, the molecular mechanisms of GSRd's neuroprotective function remain unclear. Ischemic stroke-induced oxidative stress resul... | Our results indicated that the neuroprotective function of GSRd for acute ischemic stroke might be partially explained by the up-regulation of NEIL1 and NEIL3 expressions. | yes |
27,515,482 | Is miR-103a targeting Piezo1 involved in acute myocardial infarction through regulating endothelium function? | {
"contexts": [
"Acute myocardial infarction (AMI) is commonly known as the heart attack. The molecular events involved in the development of AMI remain unclear. This study was to investigate the expression of miR-103a in patients with high blood pressure (HBP) and AMI patients with and without HBP, as well as it... | MiR-103a might be a potential biomarker of myocardium infarction and could be used as an index for the diagnosis of AMI. It may be involved in the development of high blood pressure and onset of AMI through regulating the Piezo1 expression. | yes |
27,501,360 | Does high-Speed Cycling Intervention improve Rate-Dependent Mobility in Older Adults? | {
"contexts": [
"The aim was to determine the feasibility of a six-week speed-based exercise program that could be used to initiate new exercise behaviors and improve rapid movement in older adults approaching frailty.",
"The intervention group included 14 older adults (3 males, 11 females, mean (SD) age: 70 ... | These results demonstrate that a relatively low dose of speed-based exercise can improve neuromuscular function and tests of mobility in older adults. Such a program serves as a sensible precursor to subsequent, more vigorous training or as an adjunct to a program where a velocity emphasis is lacking. | yes |
27,499,378 | Does suPAR predict Cardiovascular Events and Mortality in Patients With Asymptomatic Aortic Stenosis? | {
"contexts": [
"Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with subclinical cardiovascular damage and cardiovascular events. Whether suPAR is of prognostic value in asymptomatic patients with aortic stenosis (AS) remains unknown.",
"Plasma suPAR levels were ... | In patients with mild-moderate AS, suPAR is independently associated with the incidence of ICEs, cardiovascular mortality, and all-cause mortality. | yes |
27,496,053 | Is tobacco smoking associated with decreased semen quality? | {
"contexts": [
"Tobacco smoking is a public health issue and has been implicated in adverse reproductive outcomes including semen quality. Available data however provides conflicting findings. The objective of this study was to evaluate the effect of tobacco smoking on semen quality among men in Ghana.",
"In... | Results demonstrated a decline in semen quality in a dose dependent tobacco smoking manner. | yes |
27,506,892 | Does bmal1 induce osteoblast differentiation via regulation of BMP2 expression in MC3T3-E1 cells? | {
"contexts": [
"Mammalian circadian rhythms regulate many metabolic processes. Recent studies suggest that brain and muscle Arnt-like 1 (BMAL1), an important component of mammalian circadian rhythm, is associated with insulin signaling. Several studies have shown that insulin is associated with bone metabolism; ... | Taken together, these results demonstrate that Bmal1 promotes osteoblast differentiation by regulating BMP2 expression in MC3T3-E1 cells. | yes |
27,511,940 | Does adherence to Dietary Recommendations for Food Group Intakes be Low in the Mexican Population? | {
"contexts": [
"Given the high prevalence of obesity and noncommunicable diseases in Mexico and the key role of dietary quality in these conditions, it is important to determine Mexicans' adherence to dietary recommendations.",
"Our aim was to estimate the percentage of the Mexican population who adhere to d... | These results reveal the poor dietary quality of the Mexican population and the urgent need to shift these habits. If current intakes continue, the burden of disease due to obesity and noncommunicable chronic diseases will likely remain elevated in the Mexican population. | yes |
27,503,114 | Is simultaneous CT angiography and whole-body CT an effective imaging approach before multiorgan retrieval? | {
"contexts": [
"To assess the role of whole-body computed tomography (CT) for determining morphological suitability before multiorgan retrieval (MOR) in brain dead patients.",
"Fifty-one clinically brain dead patients (21 women, 30 men; mean age 61 year±15) were included in this prospective, single center st... | Selection of potential graft donors using whole-body CT is reliable and improves graft selection during MOR. | yes |
27,496,586 | Does comparative study of the failure rates among 3 implantable defibrillator lead? | {
"contexts": [
"After the introduction of the Biotronik Linox S/SD high-voltage lead, several cases of early failure have been observed.",
"The purpose of this article was to assess the performance of the Linox S/SD lead in comparison to 2 other contemporary leads.",
"We used the prospective Erasmus MC I... | This study demonstrates a higher failure rate of Linox S/SD high-voltage leads compared to contemporary leads. Although the mechanism of lead failure is unclear, the majority presents with abnormal electrical parameters. Comprehensive monitoring of Linox S/SD high-voltage leads includes remote monitoring to facilitate ... | yes |
27,514,729 | Does environment shape the fecal microbiome of invasive carp species? | {
"contexts": [
"Although the common, silver, and bighead carps are native and sparsely distributed in Eurasia, these fish have become abundant and invasive in North America. An understanding of the biology of these species may provide insights into sustainable control methods. The animal-associated microbiome pl... | The environment is a dominant factor shaping the fecal bacterial communities of invasive carps. Captivity alters the microbiome community structure relative to wild fish, while species differences are pronounced within habitats. Despite the absence of a true stomach, invasive carp species exhibited a core microbiota th... | yes |
27,518,469 | Does the Decline of Amylase Level of Pancreatic Juice After Pancreaticoduodenectomy predict Postoperative Pancreatic Fistula? | {
"contexts": [
"Postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreaticoduodenectomy (PD). The aim of this study is to evaluate the significance of pancreatic amylase level of pancreatic juice for PF after PD.",
"The subjects were 46 patients who underwent PD between Janua... | Decline of pancreatic amylase level of pancreatic juice can predict POPF after PD. | yes |
27,506,669 | Is pretreatment quality-of-life score a better discriminator of oesophageal cancer survival than performance status? | {
"contexts": [
"Performance status [Eastern Cooperative Oncology Group (ECOG)] is a physician-assigned score indicating a patient's fitness for treatment. Functional assessment of cancer therapy-esophagus (FACT-E) is a patient-reported, health-related quality-of-life (HRQOL) instrument containing an oesophageal ... | In patients with Stage II-III oesophageal cancer being considered for curative therapy, pretreatment FACT-E and ECS have better discrimination for survival than does ECOG. The majority of patients were ECOG 0/1. Thus, these patient-derived scores were able to discriminate survivors from non-survivors even within this c... | yes |
27,510,715 | Does algorithmic Approach With Clinical Pathology Consultation improve Access to Specialty Care for Patients With Systemic Lupus Erythematosus? | {
"contexts": [
"Harris Health System (HHS) is a safety net system providing health care to the underserved of Harris County, Texas. There was a 6-month waiting period for a rheumatologist consult for patients with suspected systemic lupus erythematosus (SLE). The objective of the intervention was to improve acce... | Clinical pathology intervention and case triaging can improve access to care in a county health care system. | yes |
27,490,916 | Does use of Estrogen-Containing Contraception be Associated With Increased Concentrations of 25-Hydroxy Vitamin D? | {
"contexts": [
"Small studies suggest exogenous estrogen may improve vitamin D status, but the etiology is unclear because women who use hormones may make lifestyle choices that differentially affect vitamin D status.",
"Our objective was to investigate the association between use of hormonal contraception a... | The increase in 25(OH)D with use of estrogen-containing contraceptives raise mechanistic questions regarding the biological pathways involved, and highlights the need for studies that examine possible endogenous estrogen effects on vitamin D. | yes |
27,509,230 | Does blood transfusion in preterm infants improve intestinal tissue oxygenation without alteration in blood flow? | {
"contexts": [
"The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age.",
"Preterm infants receiving blood transfusion were recruited to three groups: 1-7 (group 1; n = 20), 8-28 (group 2; n = 2... | Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages. | yes |
27,496,937 | Do older people remain on blood pressure agents despite being hypotensive resulting in increased mortality and hospital admission? | {
"contexts": [
"the use of antihypertensive medication in older people in order to prevent cardiovascular events is well established. The use of such agents has been encouraged by incentive schemes in the United Kingdom including the Quality and Outcomes Framework. In addition, many guidelines recommend good blo... | the results demonstrate that low SBP is associated with adverse events, it is possible that the pursuit of BP control at a population level may lead to over-treatment in certain groups of patients. This may result in an increased incidence of adverse events particularly in older people. | yes |
27,501,892 | Is decrease of pulmonary blood flow detected by phase contrast MRI correlated with a decrease in lung volume and increase of lung fibrosis area determined by computed tomography in interstitial lung disease? | {
"contexts": [
"Lung volume and pulmonary blood flow decrease in patients with interstitial lung disease (ILD). The purpose of this study was to assess the relationship between pulmonary blood flow and lung volume in ILD patients.",
"This research was approved by the institutional review board. Twenty-seven ... | In ILD, reduced pulmonary blood flow is associated with reduced lung volume and increased abnormal lung area. | yes |
27,511,201 | Does one-stage Revision With Catheter Infusion of Intraarticular Antibiotics Successfully treat Infected THA? | {
"contexts": [
"Two-stage revision surgery for infected total hip arthroplasty (THA) is commonly advocated, but substantial morbidity and expense are associated with this technique. In certain cases of infected THA, treatment with one-stage revision surgery and intraarticular infusion of antibiotics may offer a ... | Single-stage revision for chronically infected cemented THA and débridement of bone-ingrown cementless THA with late-onset acute infection followed with indwelling catheter antibiotic infusion can result in infection eradication even when resistant organisms are involved. Larger study groups would better assess this te... | yes |
27,502,743 | Is breslow density a novel prognostic feature in cutaneous malignant melanoma? | {
"contexts": [
"In 1970, Breslow described his eponymously named thickness measurement. No-one has sought to enhance the Breslow thickness (BT). The aim of this study was to demonstrate a proof of concept that the density of melanoma cells at the position where the BT is measured is a morphological prognostic bi... | We show a proof of concept that the BD represents a novel morphological prognostic biomarker that is independent of the BT, and that there is potential to combine these into a Breslow score. Larger studies are needed to validate the BD, but the simplicity of this biomarker makes it a strong candidate for translation to... | yes |
27,495,815 | Is survival associated with complete response on MRI after neoadjuvant chemotherapy in ER-positive HER2-negative breast cancer? | {
"contexts": [
"Pathological complete remission (pCR) of estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer is rarely achieved after neoadjuvant chemotherapy (NAC). In addition, the prognostic value of pCR for this breast cancer subtype is limited. We explored ... | MRI after NAC in ER-positive/HER2-negative tumors may be predictive of recurrence-free survival. A radiological complete response at MRI after NAC is associated with an excellent prognosis. | yes |
27,492,089 | Does early identification of sepsis in hospital inpatients by ward nurses increase 30-day survival? | {
"contexts": [
"Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less focus on the effect on patient outcome with better observation and treatment at the war... | In a cohort with stable mortality rates, early sepsis recognition by ward nurses may have reduced progression of disease and improved survival for patients in hospital with sepsis. | yes |
27,506,476 | Does casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorate high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling? | {
"contexts": [
"Recently, casein glycomacropeptide (GMP)-derived peptide was found to possess potent antioxidant and anti-inflammatory activities. In this study, the improvement effects and underlying molecular mechanisms of GMP-derived peptide on hepatic insulin resistance were investigated.",
"The peptide ... | IPPKKNQDKTE prevents high glucose-induced insulin resistance in HepG2 cells by modulating the IRS-1/PI3K/Akt signaling pathway through AMPK activation, indicating that IPPKKNQDKTE plays a potential role in the prevention and treatment of hepatic insulin resistance and type 2 diabetes. | yes |
27,503,374 | Does the early infant gut microbiome vary in association with a maternal high-fat diet? | {
"contexts": [
"Emerging evidence suggests that the in utero environment is not sterile as once presumed. Work in the mouse demonstrated transmission of commensal bacteria from mother to fetus during gestation, though it is unclear what modulates this process. We have previously shown in the nonhuman primate tha... | Similar to the primate, independent of maternal body mass index, a maternal high-fat diet is associated with distinct changes in the neonatal gut microbiome at birth which persist through 4-6 weeks of age. Our findings underscore the importance of counseling pregnant mothers on macronutrient consumption during pregnanc... | yes |
27,498,384 | Does cholesterol efflux capacity of high-density lipoprotein correlate with survival and allograft vasculopathy in cardiac transplant recipients? | {
"contexts": [
"Cardiac allograft vasculopathy (CAV) is a major cause of mortality after cardiac transplantation. High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) is inversely associated with coronary artery disease. In 2 independent studies, we tested the hypothesis that reduced CEC is associate... | Reduced CEC is associated with disease progression and mortality in CAV patients. These findings suggest the hypothesis that interventions to increase CEC may be useful in cardiac transplant patients for prevention or treatment of CAV. | yes |
27,518,464 | Does exenatide induce Impairment of Autophagy Flux to Damage Rat Pancreas? | {
"contexts": [
"The study aimed to explore the alteration of autophagy in rat pancreas treated with exenatide.",
"Normal Sprague-Dawley rats and diabetes-model rats induced by 2-month high-sugar and high-fat diet and streptozotocin injection were subcutaneously injected with exenatide, respectively, for 10 w... | Exenatide can activate and upregulate its receptor, GLP-1R, then impair autophagy flux and activate apoptosis in the pancreatic acinar cell, thus damaging rat pancreas.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), w... | yes |
27,510,244 | Does an integrated community TB-HIV adherence model provide an alternative to DOT for tuberculosis patients in Cape Town? | {
"contexts": [
"Cape Town, South Africa.",
"To evaluate anti-tuberculosis treatment outcomes and rate of antiretroviral therapy (ART) initiation using weekly community-based adherence support compared to daily directly observed therapy (DOT).",
"This was a retrospective analysis comparing two cohorts tre... | Weekly community-based adherence support was a viable alternative to daily DOT, with no deterioration in anti-tuberculosis treatment outcomes and an increase in ART initiation. | yes |
27,495,988 | Does next-generation sequencing survey of biliary tract cancer reveal the association between tumor somatic variants and chemotherapy resistance? | {
"contexts": [
"Biliary tract cancers (BTCs) are uncommon and are associated with a dismal prognosis. Combinations of gemcitabine and platinum chemotherapy (gemcitabine and platinum-based therapy [GP]) form the standard approach for treating advanced BTC. To characterize the spectrum of mutations and to identify... | In the largest exploratory analysis of this kind for BTC, 3 prevalent, mutually exclusive mutations represent distinct patient cohorts. These mutations are prognostic and may represent a predictive biomarker for a GP response. Prospective studies to validate these findings are needed, and they should include the incorp... | yes |
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