pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
27,496,089 | Does oral citrulline supplementation protect female mice from the development of non-alcoholic fatty liver disease ( NAFLD )? | {
"contexts": [
"Impairments of intestinal barrier function are discussed as risk factors for the development and progression of non-alcoholic fatty liver disease (NAFLD). Studies suggest an association between arginine/citrulline homeostasis and the development of liver damages. Here, the effect of an oral L-cit... | Our data suggest that the protective effects of supplementing Cit on the development of NAFLD in mice are associated with a decreased translocation of endotoxin into the portal vein. | yes |
27,496,164 | Does stress and Coping predict Adjustment and Glycemic Control in Adolescents with Type 1 Diabetes? | {
"contexts": [
"Adolescents with type 1 diabetes are at increased risk for deteriorating glycemic control, poor quality of life, and depressive symptoms. Stress and coping are related to these outcomes in adolescents with diabetes, yet few studies have examined these constructs longitudinally.",
"This study ... | The ways in which adolescents with type 1 diabetes cope with diabetes-related stress predict quality of life and symptoms of depression but not glycemic control. Through the use of screening to identify adolescent's diabetes-related stress and targeted interventions to improve coping strategies, there is potential to i... | yes |
27,502,595 | Does cryptosporidium parvum rhomboid1 have an activity in microneme protein CpGP900 cleavage? | {
"contexts": [
"Apicomplexan parasites actively release transmembrane (TM) adhesive proteins involved in host cell attachment and invasion. Rhomboids, a family of intramembrane serine proteases, cleave these secreted adhesive proteins within their TM domains as an essential step in completing the invasion proces... | Our results showed that CpROM1 is an active protease that is involved in microneme protein CpGP900 cleavage, which lay the foundation for further research on the mechanisms of C. parvum invasion. | yes |
27,495,107 | Does a negative nontreponemal and/or specific antitreponemal IgM test exclude active infectious syphilis : evidence from a rabbit infectivity test : A case report? | {
"contexts": [
"The diagnostic criteria for active infectious syphilis in the clinic are important matter of controversy and debate. So far, clinicians habitually do use the negative results of the nontreponemal and/or the specific antitreponemal IgM as the evidences of disease-free or active infection-free stat... | The definitive differential diagnosis of active infectious syphilis should be reconsidered. Moreover, selecting the appropriate penicillin preparation is important because T pallidum can reside in sequestered sites. It is necessary to treat a patient with known invasion of the central nervous system with aqueous crysta... | no |
27,491,734 | Do use and Outcomes of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients ≥90 Years of Age? | {
"contexts": [
"Intravenous tissue-type plasminogen activator (tPA) is a proven treatment for acute ischemic stroke, but there has been limited evaluation among patients aged ≥90 years.",
"We analyzed data from the Get With The Guidelines-Stroke national quality improvement registry from January 2009 to Apri... | The use of intravenous tPA among those aged ≥90 years is lower than in younger patients. When fibrinolytic therapy is used, the risk of symptomatic hemorrhage is not higher than in 66- to 89-year olds; however, mortality is higher and functional outcomes are lower. | yes |
27,506,777 | Is the transposable element environment of human genes associated with histone and expression changes in cancer? | {
"contexts": [
"Only 2 % of the human genome code for proteins. Among the remaining 98 %, transposable elements (TEs) represent millions of sequences. TEs have an impact on genome evolution by promoting mutations. Especially, TEs possess their own regulatory sequences and can alter the expression pattern of neig... | Taken together, these results suggest that the presence of TEs near genes could favor important variation in gene expression when the cell environment is modified. | yes |
27,495,278 | Does lymph Node Ratio be Less Prognostic in Melanoma When Minimum Node Retrieval Thresholds Are Not Met? | {
"contexts": [
"Lymph node ratio (LNR), positive nodes divided by nodes examined, has been proposed for prognostication in melanoma to mitigate problems with low node counts. However, it is unclear if LNR offers superior prognostication over total counts of positive nodes and nodes examined. Additionally, the pr... | LNR provides no prognostic superiority versus counts of examined and positive nodes. Moreover, the prognostic value of LNR diminishes when minimum node retrieval thresholds are not met. | yes |
27,514,759 | Does weight loss induced by bariatric surgery restore adipose tissue PNPLA3 expression? | {
"contexts": [
"Obesity and its related co-morbidities such as non-alcoholic fatty liver disease (NAFLD) are increasing dramatically worldwide. The genetic variation in Patatin-like phospholipase domain-containing protein 3 (PNPLA3), which is also called adiponutrin (ADPN), in residue 148 (I148M, rs738409) has b... | Weight loss induced by LAGB restored adipose tissue PNPLA3 expression which is suppressed by TNFα. Further studies will be required to determine the functional impact of PNPLA3 and its related genetic variation on adipose tissue inflammation and NAFLD. | yes |
27,518,439 | Does cystathionine-Gamma-Lyase Gene Deletion protect Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis? | {
"contexts": [
"Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis. The aim of this study was to investigate the role of CSE-derived H2S on inf... | Mice with CSE (an H2S synthesising enzyme) gene deletion are less susceptible to CLP-induced sepsis and associated inflammatory response through ERK1/2-NF-κB p65 pathway as evidenced by reduced inflammation, tissue damage, and LSECs defenestration and gaps formation. | yes |
27,497,459 | Does inosine enhance recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey? | {
"contexts": [
"Inosine, a naturally occurring purine nucleoside, has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.",
"To explore the effects of inosine on the recovery of mo... | These findings demonstrate that inosine can enhance recovery of function following cortical injury in monkeys. | yes |
27,491,472 | Is serum gamma-glutamyltransferase associated with subclinical atherosclerosis in patients with type 2 diabetes? | {
"contexts": [
"This study investigated the association between serum gamma-glutamyltransferase (GGT) level and subclinical atherosclerosis in patients with type 2 diabetes.",
"This cross-sectional study involved 1024 patients with type 2 diabetes mellitus. Measurement of brachial-ankle pulse wave velocity (... | Serum GGT levels were significantly associated with obesity, atherogenic dyslipidaemia, and metabolic syndrome, but not with the early and late stages of atherosclerotic vascular changes, in patients with type 2 diabetes. Serum GGT level may not be a reliable marker of subclinical atherosclerosis in type 2 diabetes. | no |
27,502,089 | Does molecular characterisation of parvoviruses from domestic cats reveal emergence of newer variants in India? | {
"contexts": [
"The present study was undertaken to characterise the viral polypeptide 2 (VP2) gene of parvovirus from domestic cats in India.",
"The faecal samples from diarrhoeic/healthy domestic cats were collected from different geographical regions of India for screening by PCR assay followed by sequenc... | Detection of CPV in both diarrhoeic/healthy cats and the occurrence of FPV infection in a vaccinated cat provide new insights into parvovirus infections in cats in India. | yes |
27,507,402 | Do patients With Short Bowel on Narcotics During 2 Randomized Trials Have Abdominal Complaints Independent of Teduglutide? | {
"contexts": [
"Narcotic agents are frequently administered to manage increased intestinal motility in patients with short bowel syndrome, but long-term use is associated with gastrointestinal (GI) complaints. This analysis evaluated the incidence of narcotic use and abdominal adverse events among patients with ... | These results suggest that patients with short bowel syndrome receiving narcotics have chronic GI complaints independent of teduglutide treatment. Data included in this analysis were derived from ClinicalTrials.gov NCT00081458 and NCT00798967 (EudraCT 2004-000438-35 and 2008-006193-15). | yes |
27,513,835 | Is urine NGAL useful in the clinical evaluation of renal function in the early course of acute pancreatitis? | {
"contexts": [
"Acute Kidney Injury (AKI) is a serious early complications in patients with acute pancreatitis (AP) that signifcantly increases mortality rates compared to patients without AKI. The early diagnosis of AKI during its treatable phases and implementation of appropriate treatment protocols can improv... | The measurement of NGAL levels, particularly in urine, is simple, easy to interpret, routinely available, and clinically useful in the assessment of dynamic changes in kidney function for patients with AP. | yes |
27,515,135 | Does haptoglobin or Hemopexin Therapy prevent Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells? | {
"contexts": [
"Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins haptoglobin and hemopexin, which bind extracellular hemoglobin and heme, respectively. Transfusion of packed red blood cells is a lifesaving therapy for pa... | In mice, the adverse effects of transfusion with SRBCs after hemorrhagic shock are ameliorated by treatment with either haptoglobin or hemopexin. Haptoglobin infusion prevents kidney injury associated with high plasma hemoglobin concentrations after resuscitation with SRBCs. Treatment with the naturally occurring human... | yes |
27,505,125 | Does decreased Soluble Guanylate Cyclase contribute to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice? | {
"contexts": [
"The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity.",
"Doxorubicin administration (20 mg/kg, intrape... | These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target. Various pharmacological sGC agonists are in clinical development or use and may represent a promising approach to limit doxorubicin-associated cardiotoxi... | yes |
27,499,508 | Does changes in lung sound during asthma progression in a guinea pig model? | {
"contexts": [
"Lung sound analysis is useful for objectively evaluating airways even in children with asymptomatic asthma. However, the relationship between lung sounds and morphological changes in the airways has not been elucidated. We examined the relationship between lung sounds and chronic morphological ch... | Lung sound intensity in the middle frequency range from 501 to 1000 Hz correlated with peripheral airway wall thickness. Inspiratory sound intensity appeared to be an indicator of morphological changes in small airways in asthma. | yes |
27,501,501 | Does the Urtica dioica extract enhance sensitivity of paclitaxel drug to MDA-MB-468 breast cancer cells? | {
"contexts": [
"Due to the chemo resistant nature of cancer cells and adverse effects of current therapies, researchers are looking for the most efficient therapeutic approach which has the lowest side effects and the highest toxicity on cancer cells. The aim of the present study was to investigate the synergic ... | Our results demonstrated that the dichloromethane extract of Urtica dioica inhibit cell growth and migration. Also, Urtica dioica extract substantially increased sensitivity of breast cancer cells to paclitaxel. Therefore, it can be used as a potential candidate for treatment of breast cancer with paclitaxel. | yes |
27,501,502 | Does miR-622 functions as a tumor suppressor and directly target E2F1 in human esophageal squamous cell carcinoma? | {
"contexts": [
"MicroRNA-622 has been proven down-regulated in many human malignancies and correlated with tumor progression. However, its role in esophageal squamous cell carcinoma (ESCC) is still unclear. The aim of this study was to explore the expression and function of miR-622 in ESCC.",
"Using quantita... | These findings indicate that miR-622 may act as a tumor suppressor in ESCC and would serve as a potential therapy target for this disease. | yes |
27,510,437 | Does melatonin prevent radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis? | {
"contexts": [
"The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis.",
"Sixty male Sprague Dawley rats were divided into six groups, as follows: control; expe... | It was found that radiotherapy increased oxidative stress, the periodontal attachment level and alveolar bone loss, and protective melatonin administration significantly reduced the oxidative parameters and prevented periodontal damage in irradiated rats with experimental periodontitis. Further research is needed regar... | yes |
27,515,912 | Is transient receptor potential ankyrin 1 ( TRPA1 ) functionally expressed in primary human osteoarthritic chondrocytes? | {
"contexts": [
"Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and neurogenic inflammation. We showed recently that TRPA1 mediates cartilage degradation and joint pain in the MIA-model of osteoarthritis (OA) s... | The TRPA1 cation channel was found to be functionally expressed in primary human OA chondrocytes, which is an original finding. The presence and inflammatory and catabolic effects of TRPA1 in human OA chondrocytes propose a highly intriguing role for TRPA1 as a pathogenic factor and drug target in OA. | yes |
27,489,360 | Does amplification of TLK2 induce Genomic Instability via Impairing the G2-M Checkpoint? | {
"contexts": [
"Managing aggressive breast cancers with enhanced chromosomal instability (CIN) is a significant challenge in clinics. Previously, we described that a cell cycle-associated kinase called Tousled-like kinase 2 (TLK2) is frequently deregulated by genomic amplifications in aggressive estrogen recepto... | Targeting TLK2 presents an attractive therapeutic strategy for the TLK2-amplified breast cancers that possess enhanced genomic instability and aggressiveness. Mol Cancer Res; 14(10); 920-7. ©2016 AACR. | yes |
27,497,986 | Does a Blockade of IGF Signaling sensitize Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities? | {
"contexts": [
"Ovarian cancer is the most lethal gynecologic malignancy, and there is an unmet clinical need to develop new therapies. Although showing promising anticancer activity, Niclosamide may not be used as a monotherapy. We seek to investigate whether inhibiting IGF signaling potentiates Niclosamide's a... | Niclosamide as a repurposed anticancer agent may be more efficacious when combined with agents that target other signaling pathways such as IGF signaling in the treatment of human cancers including ovarian cancer. | yes |
27,503,326 | Does inhibition of ADAM10 promote the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding? | {
"contexts": [
"Transport across the blood-brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer's disease (AD). One of the receptors responsible for the transport of Aβ in the BBB is the low density lipoprotein rece... | These studies demonstrate a role for ADAM10 in the ectodomain shedding of LRP1 in the brain and the clearance of Aβ across the BBB, which may provide a novel strategy for attenuating Aβ accumulation in the AD brain. | yes |
27,502,059 | Does moderate Physical Activity in Healthy Adults be Associated With Cardiac Remodeling? | {
"contexts": [
"Cardiac mass and volumes are often elevated in athletes, but it is not known whether moderate physical activity is also associated with cardiac dilatation and hypertrophy in a healthy adult population.",
"In total, 1096 adults (54% female, median age 39 years) without cardiovascular disease o... | Exercise-related cardiac remodeling is not confined to athletes, and there is a risk of overdiagnosing cardiac dilatation or hypertrophy in a proportion of active, healthy adults. | yes |
27,502,058 | Do anthracycline-Associated T1 Mapping Characteristics Are Elevated Independent of the Presence of Cardiovascular Comorbidities in Cancer Survivors? | {
"contexts": [
"Cardiovascular magnetic resonance T1 mapping characteristics are elevated in adult cancer survivors; however, it remains unknown whether these elevations are related to age or presence of coincident cardiovascular comorbidities.",
"We performed blinded cardiovascular magnetic resonance analys... | Three years after anthracycline-based chemotherapy, elevations in myocardial T1 and ECV occur independent of underlying cancer or cardiovascular comorbidities, suggesting that imaging biomarkers of interstitial fibrosis in cancer survivors are related to prior receipt of a potentially cardiotoxic cancer treatment regim... | yes |
27,495,189 | Is high salt intake associated with a higher risk of cardiovascular events : a 7.2-year evaluation of a cohort of hypertensive patients? | {
"contexts": [
"It is controversial whether high salt intake is directly associated with cardiovascular (CV) events and how far this relation is independent of blood pressure (BP). As Portugal has higher salt consumption and higher mortality by stroke than other European countries, we examined whether salt intak... | In a cohort of hypertensive patients, high salt intake independently predicts the occurrence of CV events, particularly of stroke. | yes |
27,507,635 | Is palliative homecare associated with reduced high- and low-acuity emergency department visits at the end of life : A population-based cohort study of cancer decedents? | {
"contexts": [
"Prior work shows that palliative homecare services reduce the subsequent need for hospitalizations and emergency services; however, no study has investigated whether this association is present for emergency department visits of high acuity or whether it only applies to low-acuity emergency depar... | Receiving homecare nursing with palliative intent may decrease the need for dying cancer patients to visit the emergency department, for both high and low-acuity visits, compared to receiving general homecare nursing. Policy implications include building support for additional training in palliative care to generalist ... | yes |
27,489,082 | Is actual lowering effect of metabolic syndrome on serum prostate-specific antigen levels partly concealed by enlarged prostate : results from a large-scale population-based study? | {
"contexts": [
"To clarify the lowering effect of metabolic syndrome (MetS) on serum prostate-specific antigen (PSA) levels in a Chinese screened population.",
"A total of 45 540 ostensibly healthy men aged 55-69 years who underwent routine health check-ups at Beijing Shijitan Hospital between 2008 and 2015 ... | The actual lowering effect of MetS on serum PSA levels was partly concealed by the enlarged prostate in men with MetS, and the presence of MetS was independently associated with lower serum PSA levels. Urologists need to be aware of the effect of MetS on serum PSA levels and should discuss this subject with their patie... | yes |
27,498,442 | Does leucocyte count indicate carotid plaque instability in stroke patients? | {
"contexts": [
"Increasing evidence points to the inflammatory character of atherosclerosis and several parameters of inflammation have been proposed as cerebrovascular risk markers. The objective of the research was to examine the connection of serum inflammatory parameters and ultrasound (US) characteristics o... | The number of Le is associated with the phenomenon of carotid plaque instability and may be a useful additional marker of increased risk for developing acute cerebral infarction. | yes |
27,496,871 | Does c-type natriuretic peptide and natriuretic peptide receptor B signalling inhibit cardiac sympathetic neurotransmission and autonomic function? | {
"contexts": [
"B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized... | C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation... | yes |
27,496,870 | Does comparative DNA methylation and gene expression analysis identify novel genes for structural congenital heart diseases? | {
"contexts": [
"For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expres... | By interrogating DNA methylation and gene expression data, we identify two novel mechanism contributing to the phenotypic expression of CHDs: aberrant methylation of promoter CpG islands and methylation alterations leading to differential splicing. | yes |
27,502,369 | Does postnatal Loss of Kindlin-2 lead to Progressive Heart Failure? | {
"contexts": [
"The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated muscle structure and function. Multiple costamere-associated proteins, such as integrins and integrin-interacting proteins, have been iden... | Kindlin-2 is required to maintain integrin β1D protein stability. Postnatal loss of Kindlin-2 from cardiac myocytes leads to progressive heart failure, showing the importance of costameric proteins like Kindlin-2 for homeostasis of normal heart function. | yes |
27,517,689 | Do residency program trainee-satisfaction correlate with results of the European board examination in neurosurgery? | {
"contexts": [
"Substantial country differences in neurosurgical training throughout Europe have recently been described, ranging from subjective rating of training quality to objective working hours per week. The aim of this study was to analyse whether these differences translate into the results of the writte... | With every one-step improvement on the country-specific satisfaction score for theoretical training, the score in the EBE-NS Part 1 increased by 3.8 %. With every one-step improvement on the country-specific satisfaction score for practical training, the score in the EBE-NS Part 2 increased by 9.47 %. Improving trainin... | yes |
27,495,970 | Is esophageal Mucosal Impedance Pattern Distinct in Patients With Extraesophageal Reflux Symptoms and Pathologic Acid Reflux? | {
"contexts": [
"Current diagnostic tests for gastroesophageal reflux disease (GERD) do not consistently measure chronicity of reflux. Mucosal impedance (MI) is a minimally invasive measurement to assess esophageal conductivity changes due to GERD. We aimed to investigate MI pattern in patients with symptoms of e... | Patients with symptoms of EER and evidence of acid reflux have an MI lower than those without at 2 cm above the SCJ, with a trend at 5 cm and 10 cm as well. MI may be a tool to assess presence of GERD in patients presenting with EER symptoms. | yes |
27,493,268 | Does in vivo imaging of antileukemic drug asparaginase reveal a rapid macrophage mediated clearance from the bone marrow? | {
"contexts": [
"The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic leukemia, acts by depleting asparagine from the blood. However, little is known about its pharmacokinetics and mechanisms of therapy resistance are poorly understood. Here, we explored the in vivo biodistr... | We show that asparaginase is rapidly cleared from the serum by liver, spleen and bone marrow-resident phagocytic cells. As a consequence of this efficient uptake and protease mediated degradation, particularly bone marrow resident macrophages may provide a protective niche to leukemic cells. | yes |
27,520,407 | Does sodium Hypochlorite inactivate Lipoteichoic Acid of Enterococcus faecalis by Deacylation? | {
"contexts": [
"Enterococcus faecalis is a pathogenic gram-positive bacterium closely associated with apical periodontitis. Although sodium hypochlorite (NaOCl) has been used as a common endodontic irrigant to eradicate bacteria in the root canal, it has not been elucidated whether NaOCl attenuates the inflammat... | NaOCl deacylates the glycolipid moiety of EfLTA, which fails to activate TLR2, leading to the reduced production of inflammatory mediators. | yes |
27,515,722 | Does trends and correlate of substance use disorders among probationers and parolees in the United States 2002-2014? | {
"contexts": [
"Substance use and crime/recidivism are irrevocably linked. We explore the nuances of this association by highlighting the prevalence, trends, and correlates of substance use dsorders in a large group of probationers/parolees.",
"We examined SUDs among probationers and parolees in the United S... | This study indicates that SUDs are higher among probationer/parolees as compared to their non-supervised counterparts - between four and nine times higher - and these levels have changed little in recent years. Effectively responding to SUDs in this population may enhance adherence to supervision requirements, prevent ... | yes |
27,510,618 | Does post-exercise heart-rate recovery correlate to resting heart-rate variability in healthy men? | {
"contexts": [
"The relationship between post-exercise heart-rate recovery (HRR) and resting cardiac autonomic modulation is an incompletely explored issue.",
"To correlate HRR with resting supine and orthostatic autonomic status.",
"HRR at the 1st, 3th, and 5th min following maximal treadmill exercise w... | HRR from the 1st to 5th min post-exercise negatively correlated with parasympathetic modulation in resting orthostatic, but showed no correlation in supine position. At the 3rd and 5th min, a positive correlation with combined sympathetic-parasympathetic modulation in both positions was observed. | yes |
27,519,268 | Does low dose dietary nitrate improve endothelial dysfunction and plaque stability in the? | {
"contexts": [
"Nitric oxide (NO) is an important vascular signalling molecule. NO is synthesised endogenously by endothelial nitric oxide synthase (eNOS). An alternate pathway is exogenous dietary nitrate, which can be converted to nitrite and then stored or further converted to NO and used immediately. Atheros... | Low and moderate dose nitrate significantly improved endothelial function and atherosclerotic plaque composition in ApoE | yes |
27,500,956 | Does uropathogenic Escherichia coli release Extracellular Vesicles That Are Associated with RNA? | {
"contexts": [
"Bacterium-to-host signalling during infection is a complex process involving proteins, lipids and other diffusible signals that manipulate host cell biology for pathogen survival. Bacteria also release membrane vesicles (MV) that can carry a cargo of effector molecules directly into host cells. S... | These data add to the growing evidence of pathogenic bacterial MV being associated a wide range of RNAs. It further raises the plausibility for MV-RNA-mediated cross-kingdom communication whereby they influence host cell function during the infection process. | yes |
27,520,290 | Are older patients still under-represented in clinical trials of Alzheimer 's disease? | {
"contexts": [
"The age gap between participants in trials and patients who could benefit from the drugs studied has been widely documented across different clinical areas. Patients with dementia included in clinical research are systematically younger than those in the general population. We examined the age ga... | Patients enrolled in clinical trials on Alzheimer's disease are far from being representative of actual distribution of the patients in the general population. Clinical research should not be designed and conducted overlooking the fact that the majority of individuals with Alzheimer's disease are likely to be 80 or old... | yes |
27,516,129 | Does encoding of speech sound at auditory brainstem level in good and poor hearing aid performers? | {
"contexts": [
"Hearing aids are prescribed to alleviate loss of audibility. It has been reported that about 31% of hearing aid users reject their own hearing aid because of annoyance towards background noise. The reason for dissatisfaction can be located anywhere from the hearing aid microphone till the integri... | The result of the present study suggests that neural encoding of speech sound at the brainstem level might be mediated distinctly in good hearing aid performers from that of poor hearing aid performers. Thus, it can be inferred that subtle physiological changes are evident at the auditory brainstem in a person who is w... | yes |
27,516,122 | Is preoperative Statin Use at the Time of Radical Prostatectomy Associated With Biochemical Recurrence or Pathologic Upgrading? | {
"contexts": [
"To determine the association of statin use with oncological outcomes and risk of pathologic upgrading following radical prostatectomy.",
"Using a prospectively populated database of 3042 men who underwent open radical prostatectomy, patients were grouped according to reported statin use at th... | Preoperative statin use at the time of radical prostatectomy was not associated with biochemical recurrence or risk of pathologic upgrading in this cohort. These data add to the existing body of literature suggesting that statin use is not associated with more favorable clinical outcomes following radical prostatectomy... | no |
27,489,723 | Does dietary beet pulp decrease taurine status in dogs fed low protein diet? | {
"contexts": [
"It is known that large dogs who are fed lamb and rice diets are at increased risk to develop taurine-deficiency-induced dilated cardiomyopathy. Since dogs obligatorily conjugate bile acids (BA) with taurine, we determined whether rice bran (RB) or other fibers (cellulose; CL, beet pulp; BP) would... | These results do not support the hypothesis that RB is likely to be a primary cause of lamb meal and rice diets, increasing the risk of taurine deficiency in large dogs. However these indicate that BP may contribute to a decrease taurine status in dogs by increasing excretion of fecal BA and decreasing protein digestib... | yes |
27,494,447 | Is dietary counseling associated with an improved lipid profile in children with familial hypercholesterolemia? | {
"contexts": [
"Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). Guidelines recommend cholesterol-lowering medication from 8 to 10 years of age and dietary recommendations. Little is known about th... | FH children had a higher intake of SFA than recommended and the SFA intake was positively correlated with plasma TC, LDL-C and apo B levels in FH children not using statins. Importantly, the plasma lipid profile was improved in FH children after dietary counseling where focus was on reducing intake of SFA and dietary c... | yes |
27,506,200 | Does a tissue-specific protein purification approach in Caenorhabditis elegans identify novel interaction partners of DLG-1/Discs large? | {
"contexts": [
"Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissu... | The method we present here is able to purify protein complexes from specific tissues. We uncovered a series of DLG-1 interactors, and conclude that ATAD-3 is a biologically relevant interaction partner of DLG-1. Finally, we conclude that MAPH-1.1 is a microtubule-associated protein of the MAP1 family and a candidate ne... | yes |
27,497,368 | Does invasive aortic pulse wave velocity as a marker for arterial stiffness predict outcome of renal sympathetic denervation? | {
"contexts": [
"A recurrent finding of trials on renal sympathetic denervation is a certain percentage of non-responders. The aim of this study was to examine the influence of arterial stiffness to predict response.",
"Eighty-eight patients were included in the study. Arterial stiffness was measured by invas... | Patients with lower pulse wave velocity showed a significantly better response to denervation. These findings emphasise that pulse wave velocity might be used as a selection criterion for renal denervation. | yes |
27,520,310 | Is dCLK1 up-regulated and associated with metastasis and prognosis in colorectal cancer? | {
"contexts": [
"Metastasis is a primary cause of colorectal cancer (CRC)-related death, and cancer stem cells (CSCs) are thought to be majorly responsible for initiating metastatic behaviors. Doublecortin-like kinase 1 (DCLK1) was recently discovered to be a marker for gastrointestinal CSCs. Here, we aimed to ex... | DCLK1 up-regulation may play a contributory role in CRC metastasis and poor prognosis via activation of EMT. DCLK1 may serve as an independent predictor for CRC prognosis. | yes |
27,520,319 | Is metastasectomy for metastatic renal cell carcinoma in the era of modern systemic treatment : C-reactive protein an independent predictor of overall survival? | {
"contexts": [
"To define the predictive capability of serum C-reactive protein for a contemporary patient collective undergoing metastasectomy for metastatic renal cell carcinoma with access to modern targeted therapies.",
"A total of 88 patients treated with metastasectomy for metastatic renal cell carcino... | Elevated C-reactive protein >5 mg/L was identified as an independent predictor of survival in a contemporary patient collective undergoing metastasectomy for metastatic renal cell carcinoma. Future analyses and risk stratification tools for patients undergoing metastasectomy for metastatic renal cell carcinoma should a... | yes |
27,509,845 | Does a pilot study of parent education intervention improve early childhood development among toddlers with sickle cell disease? | {
"contexts": [
"Young children with sickle cell disease (SCD) are at risk for cognitive delay. In addition to biologic risk factors associated with SCD, environmental factors contribute to cognitive dysfunction within this cohort.",
"We completed a single-arm, prospective cohort study. Children with SCD betw... | We report longitudinal results of the first home visitation program within the early childhood SCD population and show significant improvement in cognitive and EL development. Additionally, home environment was a significant predictor of cognitive development. Randomized controlled trials to test the impact of interven... | yes |
27,519,875 | Does stomal maturation increase the rate of tracheocutaneous fistulas? | {
"contexts": [
"To determine the rate of persistent tracheocutaneous fistula (TCF) in pediatric patients managed with stomal maturation at the time of the tracheostomy.",
"Retrospective chart analysis of all cases of tracheostomy performed at a tertiary pediatric care center between 2001 and 2011.",
"The... | Comparable rates of persistent TCF with stomal maturation (27%) and without maturation (22%) were found in this single institution's 10-year experience. | no |
27,506,680 | Is high T2-weighted signal intensity associated with elevated troponin T in hypertrophic cardiomyopathy? | {
"contexts": [
"Areas of high signal intensity (HighT2) on T2-weighted cardiovascular magnetic resonance (CMR) imaging have been demonstrated in hypertrophic cardiomyopathy (HCM). It has been hypothesised that HighT2 may indicate active tissue injury in HCM. In this context, we studied HighT2 in relation to card... | In this CMR study of patients with HCM, we observed HighT2 in a quarter of patients, and demonstrated that HighT2 was associated with an elevated hs-cTnT. This observation, combined with the very high negative predictive value of an undetectable hs-cTnT for HighT2, provides supportive evidence for the hypothesis that H... | yes |
27,519,933 | Is combination of 5 % phenylephrine and 0.5 % tropicamide eyedrops for pupil dilation in neonates twice as effective as 0.5 % tropicamide eyedrops alone? | {
"contexts": [
"Comparison of the efficacy of tropicamide eyedrops to the combination of 0.5% tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity.",
"A prospective, randomized, double-blind study was conducte... | The dilated pupil surface area for the combination of 5% phenylephrine and 0.5% tropicamide was almost twice that for 0.5% tropicamide eyedrops alone and provided significantly superior quality of the eye fundus examination. | yes |
27,511,354 | Do apitherapy products enhance the recovery of CCL4-induced hepatic damages in rats? | {
"contexts": [
"Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats.",
"Animals were fed with honeybee products for 7 days following CCl4 i... | Our results suggest that honey, propolis, pollen, and royal jelly significantly enhanced the healing of CCl4-induced liver damage, partially due to their antioxidant properties and bioavailability. | yes |
27,511,352 | Does intrabone marrow injection enhance placental mesenchymal stem cellmediated support of hematopoiesis in mice? | {
"contexts": [
"In order to determine the synergistic effects of human placental mesenchymal stem cells (PMSCs) on hematopoiesis in vivo, we compared the intrabone marrow injection (IBMI) with the conventional intravenous injection (IVI).",
"C57BL/6 recipient mice conditioned with lethal doses of irradiation... | Our results not only elucidated the role of PMSCs in promoting hematopoiesis, but also revealed the therapeutic potential of the combination of PMSCs and IBMI in transplantation. | yes |
27,492,980 | Does complement C3a predict outcome in cardiac resynchronization therapy of heart failure? | {
"contexts": [
"The chronic inflammation plays an important role in heart failure and complement components might be useful markers of the prognosis. We set out to evaluate their predictive value in the clinical outcomes of patients with cardiac resynchronization therapy (CRT).",
"We determined the complemen... | In patients with CRT, elevated C3a levels increase the risk of mortality independent of the NT-proBNP levels or other factors. CRT exerts anti-inflammatory effect by reducing the complement activation. | yes |
27,514,530 | Does over-expression of long noncoding RNA BANCR inhibit malignant phenotypes of human bladder cancer? | {
"contexts": [
"Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) ... | These data suggested that BANCR represents a tumor suppressor player in bladder cancer, contributes to tumor proliferation, apoptosis and migration, and may serve as a new candidate biomarker and a potential therapeutic target for patients with BC. | yes |
27,495,002 | Does whole genome sequencing reveal mycobacterial microevolution among concurrent isolates from sputum and blood in HIV infected TB patients? | {
"contexts": [
"In the context of advanced immunosuppression, M. tuberculosis is known to cause detectable mycobacteremia. However, little is known about the intra-patient mycobacterial microevolution and the direction of seeding between the sputum and blood compartments.",
"From a diagnostic study of HIV-in... | Among HIV-infected patients with poor cellular immunity, infection with multiple strains of M. tuberculosis was found in half of the patients. In those patients with identical strains, whole genome sequencing indicated that M. tuberculosis intra-patient microevolution does occur in a few patients, yet did not reveal a ... | yes |
27,502,312 | Does imaging mass spectrometry assist in the classification of diagnostically challenging atypical Spitzoid neoplasms? | {
"contexts": [
"Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas.",
"We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate th... | IMS diagnosis of ASN better predicted clinical outcome than histopathology. Diagnosis of Spitzoid melanoma by IMS was strongly associated with aggressive clinical behavior. IMS analysis using a proteomic signature may improve the diagnosis and prediction of outcome/risk stratification for patients with ASN. | yes |
27,493,871 | Does degenerin channel activation cause caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle? | {
"contexts": [
"Declines in skeletal muscle structure and function are found in various clinical populations, but the intramuscular proteolytic pathways that govern declines in these individuals remain relatively poorly understood. The nematode Caenorhabditis elegans has been developed into a model for identifyi... | Constitutive cationic influx into muscle appears to cause caspase degradation of cytosolic proteins as the result of mitochondrial dysfunction, which may be relevant to ageing and sarcopenia. | yes |
27,493,873 | Is p62/SQSTM1 but not LC3 accumulated in sarcopenic muscle of mice? | {
"contexts": [
"We investigated the pathway of autophagy signaling linked to sarcopenia of mice.",
"Young adult (3-month) and aged (24- month) C57BL/6J mice were used. Using real-time PCR, Western blotting, and immunohistochemical microscopy, we evaluated the amounts of p62/SQSTM1, LC3, and Beclin-1 in the q... | Sarcopenia in mice appears to include a marked defect of autophagy signaling. | yes |
27,493,875 | Does salidroside alleviate cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling? | {
"contexts": [
"Cachexia has a devastating impact on survival and quality of life for many cancer patients and contributes to nearly one-third of all cancer deaths; also, it is associated with poor responses to chemotherapy and survival. A better understanding of the underlying mechanisms of cancer-associated ca... | In the current study, the exciting effect of salidroside on CAC suggested that salidroside supplementation might be a promising approach for a multi-targeted therapy for the treatment of CAC. | yes |
27,513,455 | Does rAMP1 suppress mucosal injury from dextran sodium sulfate-induced colitis in mice? | {
"contexts": [
"Calcitonin gene-related peptide (CGRP) is thought be involved in the modulation of intestinal motility. CGRP receptor is composed of receptor activity-modifying protein (RAMP) 1 combined with calcitonin receptor-like receptor (CRLR) for CGRP. We investigated the role of CGRP in mice with experime... | The findings of this study suggest that RAMP1 exerted mucosal protection in DSS-induced colitis via attenuation of recruitment of inflammatory cells and of pro-inflammatory cytokines. This article is protected by copyright. All rights reserved. | yes |
27,501,343 | Do biomechanical comparison of sinus floor elevation and alternative treatment methods for dental implant placement? | {
"contexts": [
"In this study, we compared the success of sinus lifting and alternative treatment methods in applying dental implants in cases lacking adequate bone due to pneumatization of the maxillary sinus.",
"In a computer environment, 3D models were created using computerized tomography data from a pat... | Based on the results of this study, the LSL method should be the first choice among treatment options. Considering its successful results under conditions of oblique forces, the SIP method may be preferable to the TIP method. In contrast, every effort should be made to avoid the use of DCs. | yes |
27,515,502 | Does lipopolysaccharide-induced preconditioning protect against traumatic spinal cord injury by upregulating Nrf2 expression in rats? | {
"contexts": [
"Lipopolysaccharide (LPS)-induced preconditioning protects neurons against traumatic spinal cord injury (TSCI) in rats. This study sought to test whether Nrf2, a transcription factor, mediated LPS-induced preconditioning.",
"The TSCI model was established using a standardized NYU impactor on a... | LPS preconditioning effectively alleviates TSCI-induced impairment and preserves nervous function in a Nrf2-dependent manner. | yes |
27,498,047 | Does rACK1 overexpression associate with pancreatic ductal adenocarcinoma growth and poor prognosis? | {
"contexts": [
"The receptor for activated protein kinase C (RACK1) is a scaffold protein involved in multiple intracellular signal pathways. Previous studies have shown that RACK1 is associated with the progression of multiple cancer types, including hepatocellular carcinoma and gastric cancer. However, the rol... | Our results suggest that RACK1 could play an important role in the tumorigenesis of PDAC and serve as a potential therapeutical target in PDAC treatment. | yes |
27,502,180 | Does imaging-genomics reveal driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma? | {
"contexts": [
"Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic association... | GBM volumetric features extracted from MRI are significantly enriched for information about the biological state of a tumor that impacts patient outcomes. Clinical decision-support systems could exploit this information to develop personalized treatment strategies on the basis of noninvasive imaging. | yes |
27,517,645 | Does exposure of Stored Packed Erythrocytes to Nitric Oxide prevent Transfusion-associated Pulmonary Hypertension? | {
"contexts": [
"Transfusion of packed erythrocytes stored for a long duration is associated with increased pulmonary arterial pressure and vascular resistance. Prolonged storage decreases erythrocyte deformability, and older erythrocytes are rapidly removed from the circulation after transfusion. The authors stu... | NO treatment of stored packed erythrocytes before transfusion oxidizes cell-free oxyhemoglobin to methemoglobin, prevents subsequent NO scavenging in the pulmonary vasculature, and limits pulmonary hypertension. NO treatment increases erythrocyte deformability and erythrocyte survival after transfusion. NO treatment mi... | yes |
27,493,792 | Is fatigue in primary Sjögren 's syndrome associated with lower levels of proinflammatory cytokines? | {
"contexts": [
"This article reports relationships between serum cytokine levels and patient-reported levels of fatigue, in the chronic immunological condition primary Sjögren's syndrome (pSS).",
"Blood levels of 24 cytokines were measured in 159 patients with pSS from the United Kingdom Primary Sjögren's Sy... | Cytokines, pain and depression appear to be the most powerful predictors of fatigue in pSS. Our data challenge the notion that proinflammatory cytokines directly mediate fatigue in chronic immunological conditions. Instead, we hypothesise that mechanisms regulating inflammatory responses may be important. | yes |
27,520,057 | Is compliance with the current recommendations for prescribing antibiotics for paediatric community-acquired pneumonia improving : data from a prospective study in a French network? | {
"contexts": [
"Lower respiratory tract infection is a common cause of consultation and antibiotic prescription in paediatric practice. The misuse of antibiotics is a major cause of the emergence of multidrug-resistant bacteria. The aim of this study was to evaluate the frequency, changes over time, and determin... | We observed a significant increase in the compliance with recommendations, with a reduction in the prescription of broad-spectrum antibiotics, efforts to improve antibiotic prescriptions must continue. | yes |
27,514,748 | Is bnPME progressively induced after microspore reprogramming to embryogenesis , correlating with pectin de-esterification and cell differentiation in Brassica napus? | {
"contexts": [
"Pectins are one of the main components of plant cell walls. They are secreted to the wall as highly methylesterified forms that can be de-esterified by pectin methylesterases (PMEs). The degree of methylesterification of pectins changes during development, PMEs are involved in the cell wall remod... | The results show that the change of developmental programme of the microspore involves changes in pectin esterification associated with proliferation and differentiation events, which may cause the cell wall remodeling during the process. The findings indicate pectin-related modifications in the cell wall during micros... | yes |
27,505,854 | Does n-pentyl-nitrofurantoin induce apoptosis in HL-60 leukemia cell line by upregulating BAX and downregulating BCL-xL gene expression? | {
"contexts": [
"Nitrofurantoin is a nitroderivative antibiotic that has bactericidal activity against pathogens causing urinary tract infection. A few studies have reported that nitrofurantoin has cytotoxic activity against cancer cells; however, nitrofurans remain a poorly explored class of compounds with respe... | The results indicate that NFP induces apoptosis in HL-60 cells by upregulating BAX and downregulating BCL-xL. | yes |
27,505,855 | Does puerarin inhibit the inflammatory response in atherosclerosis via modulation of the NF-κB pathway in a rabbit model? | {
"contexts": [
"The isoflavone puerarin [7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one 8-(β-D-glucopyranoside)] possesses many biological activities. In this study, we investigated the effects of puerarin on adhesion molecules (AMs), including serum levels of intercellular adhesion molecule-1 (ICAM-1), vascul... | This study indicates that the effect of puerarin on the suppression of atherosclerosis was connected with an inhibited inflammatory response and reduced NF-κB activation. | yes |
27,519,651 | Does comprehensive repeatome annotation reveal strong potential impact of repetitive elements on tomato ripening? | {
"contexts": [
"Plant genomes are populated by different types of repetitive elements including transposable elements (TEs) and simple sequence repeats (SSRs) that can have a strong impact on genome size and dynamic as well as on the regulation of gene transcription. At least two-thirds of the tomato genome is c... | Altogether, our study emphasizes the fractionation as defined by repeat content in the tomato genome and enables to further characterize the specificities of each genomic compartment. Additionally, our results present strong associations between differentially regulated genes, differentially methylated regions and repe... | yes |
27,504,157 | Do cAMP-Epac Pathway Stimulation Modulate Connexin-43 and MicroRNA-21 Expression in Glioma Cells? | {
"contexts": [
"Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. Connexin 43 (Cx43) and micro ribonucleic acid-21(miR-21) are among molecules ... | These findings demonstrate that low grade astrocytoma cells have better response to our pharmacological interventions. | yes |
27,503,506 | Does natal habitat imprinting counteract the diversifying effects of phenotype-dependent dispersal in a spatially structured population? | {
"contexts": [
"Habitat selection may have profound evolutionary consequences, but they strongly depend on the underlying preference mechanism, including genetically-determined, natal habitat and phenotype-dependent preferences. It is known that different mechanisms may operate at the same time, yet their relati... | Taken together, the current and previous findings that pied flycatchers do not always settle in the habitat to which they are best suited suggest that their strong tendency to return to the natal patch regardless of their body size might lead to maladaptive settlement decisions and thus constrain the potential of pheno... | yes |
27,496,872 | Does endothelial Jag1-RBPJ signalling promote inflammatory leucocyte recruitment and atherosclerosis? | {
"contexts": [
"To determine the role of NOTCH during the arterial injury response and the subsequent chronic arterial-wall inflammation underlying atherosclerosis.",
"We have generated a mouse model of endothelial-specific (Cdh5-driven) depletion of the Notch effector recombination signal binding protein fo... | Notch signalling pathway inactivation decreases leucocyte rolling, thereby preventing endothelial dysfunction and vascular inflammation. Attenuation of Notch signalling might provide a treatment strategy for atherosclerosis. | yes |
27,491,446 | Does damage Patterns at the Head-Stem Taper Junction help Understand the Mechanisms of Material Loss? | {
"contexts": [
"Material loss at the taper junction of metal-on-metal total hip arthroplasties has been implicated in their early failure. The mechanisms of material loss are not fully understood; analysis of the patterns of damage at the taper can help us better understand why material loss occurs at this junct... | These material loss maps allow us to suggest different mechanisms that dominate the cause of the material loss in each pattern: (1) corrosion, (2) mechanically assisted corrosion, or (3) intraoperative damage or poor size tolerances leading to toggling of trunnion in taper. | yes |
27,490,714 | Does posttraumatic stress disorder influence the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans? | {
"contexts": [
"Although posttraumatic stress disorder (PTSD) and chronic pain frequently occur in tandem, the pathophysiological mechanisms mediating this comorbidity are poorly understood. Because excessive inflammation occurs in both conditions, we examined the cerebrospinal fluid (CSF) concentrations of infl... | These findings show significant central nervous system (CNS) differences in the inflammatory response to a deep pain stimulus in combat veterans with and without PTSD. They support the concept that abnormally elevated neuroinflammatory response to pain stimuli may be one CNS mechanism accounting for the high co-occurre... | yes |
27,495,386 | Do [ EuroSCORE underestimate the mortality risk in cardiac valve surgery of Mexican population ]? | {
"contexts": [
"The EuroSCORE (European System for cardiac operative risk evaluation) stratifies cardiac risk surgery in easy and accessible manner; it was validated in North America with good results but in many countries of Latin America is used routinely without prior validation. Our objective was to validate... | In the INCICh 88.7% of patients with cardiac valve surgery had intermediate to high risk and EuroSCORE underestimated the risk of mortality. | yes |
27,494,037 | Is methadone superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer? | {
"contexts": [
"Cancer pain is still inadequately treated in up to 60% of cancer patients. Based on the additional effect on the N-Methyl-d-Aspartate receptor, we expected that methadone (Met) could provide better pain relief than fentanyl (Fen) in cancer pain with a neuropathic pain component.",
"A randomis... | This is the first study to compare the effects of Met to Fen in cancer patients with a neuropathic pain component. Based on the results of this study, Met should be considered in the treatment of oncological pain with a neuropathic component. | yes |
27,496,751 | Does targeting factor VIII expression to platelets for hemophilia A gene therapy induce an apparent thrombotic risk in mice? | {
"contexts": [
"Essentials Platelet-Factor (F) VIII gene therapy is a promising treatment in hemophilia A. This study aims to evaluate if platelet-FVIII expression would increase the risk for thrombosis. Targeting FVIII expression to platelets does not induce or elevate thrombosis risk. Platelets expressing FVII... | Background Targeting factor (F) VIII expression to platelets is a promising gene therapy approach for hemophilia A, and is successful even in the presence of inhibitors. It is well known that platelets play important roles not only in hemostasis, but also in thrombosis and inflammation. Objective To evaluate whether pl... | no |
27,491,833 | Is aNGPTL2 associated with an increased risk of cardiovascular events and death in diabetic patients? | {
"contexts": [
"A high serum angiopoietin-like 2 (ANGPTL2) concentration is an independent risk factor for developing diabetes and is associated with insulin resistance and atherosclerosis. In this work, we have examined the impact of serum ANGPTL2 on improving cardiovascular (CV) risk stratification in patients... | In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE. Therefore, ANGPTL2 is a promising candidate biomarker for improving risk stratification in type 2 diabetes patients, and may prove to be a valuable therapeutic target. | yes |
27,513,822 | Do aRDS Subphenotypes Respond Differently to Randomized Fluid Management Strategy? | {
"contexts": [
"We previously identified two ARDS subphenotypes in two separate randomized controlled trials, with differential response to positive end-expiratory pressure. The current analysis sought to identify these subphenotypes in a third ARDS cohort, to test whether subphenotypes respond differently to fl... | This analysis confirms the presence of two ARDS subphenotypes that can be accurately identified with a limited number of variables and that responded differently to randomly-assigned fluid management. These findings support the presence of ARDS subtypes that may require different treatment approaches. | yes |
27,492,617 | Does a Pleiotropic Missense Variant in SLC39A8 be Associated With Crohn 's Disease and Human Gut Microbiome Composition? | {
"contexts": [
"Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the I... | Our results suggest that an SLC39A8-dependent shift in the gut microbiome could explain its pleiotropic effects on multiple complex diseases including CD. | yes |
27,499,935 | Is prognostic value of preoperative neutrophil-lymphocyte ratio superior to platelet-lymphocyte ratio for survival in patients who underwent complete resection of thymic carcinoma? | {
"contexts": [
"Preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have prognostic value in patients with various operable tumors. The aim of our study was to determine whether NLR and PLR are predictive of survival in thymic carcinoma patients after complete resection.",
"A t... | The preoperative NLR of >4.1 was significantly associated with larger tumor size, more advanced Masaoka stages and reduced DFS and OS, but was not an independent predictor of survival in thymic carcinoma patients after complete resection. | yes |
27,502,441 | Does microRNA-21 mediate Angiotensin II-Induced Liver Fibrosis by Activating NLRP3 Inflammasome/IL-1β Axis via Targeting Smad7 and Spry1? | {
"contexts": [
"Angiotensin II (AngII), a vasoconstrictive peptide of the renin-angiotensin system (RAS), promotes hepatic fibrogenesis and induces microRNA-21(mir-21) expression. Angiotensin-(1-7) [Ang-(1-7)] is a peptide of the RAS, which attenuates liver fibrosis. Recently, it was reported that the NOD-like r... | Mir-21 mediates AngII-activated NLRP3 inflammasome and resultant HSC activation via targeting Spry1 and Smad7. Ang-(1-7) protected against BDL or AngII infusion-induced hepatic fibrosis and inhibited mir-21 expression. Antioxid. Redox Signal. 00, 000-000. | yes |
27,503,185 | Does leukocyte concentration and composition in platelet-rich plasma ( PRP ) influence the growth factor and protease concentrations? | {
"contexts": [
"Platelet-rich plasma (PRP) therapy has become an increasingly popular treatment for orthopaedics and sports-related injuries, and various clinically available PRP preparation methods exist. However, the differences in PRP quality among numerous preparation methods remain unclear. Specifically, th... | These findings demonstrate that leukocytes strongly influence the quality of PRPs. Therefore, modifying the PRP preparation method according to the pathology is essential to achieve better clinical results with PRP therapy. | yes |
27,492,790 | Is reduction of methicillin-resistant Staphylococcus aureus infection in long-term care possible while maintaining patient socialization : A prospective randomized clinical trial? | {
"contexts": [
"Antibiotic resistance is a challenge in long-term care facilities (LTCFs). The objective of this study was to demonstrate that a novel, minimally invasive program not interfering with activities of daily living or socialization could lower methicillin-resistant Staphylococcus aureus (MRSA) diseas... | On-site MRSA surveillance with targeted decolonization resulted in a significant decrease in clinical MRSA infection among LTCF residents. | yes |
27,497,320 | Does hIV Distal Neuropathic Pain be Associated with Smaller Ventral Posterior Cingulate Cortex? | {
"contexts": [
"Despite modern antiretroviral therapy, HIV-associated neuropathy is one of the most prevalent, disabling and treatment-resistant complications of HIV disease. The presence and intensity of distal neuropathic pain is not fully explained by the degree of peripheral nerve damage. A better understand... | The posterior cingulate is thought to be involved in inhibiting the perception of painful stimuli. Mechanistically a smaller posterior cingulate cortex structure may be related to reduced anti-nociception contributing to increased distal neuropathic pain. | yes |
27,493,870 | Do muscle RING-finger 2 and 3 maintain striated-muscle structure and function? | {
"contexts": [
"The Muscle-specific RING-finger (MuRF) protein family of E3 ubiquitin ligases is important for maintenance of muscular structure and function. MuRF proteins mediate adaptation of striated muscles to stress. MuRF2 and MuRF3 bind to microtubules and are implicated in sarcomere formation with notice... | The redundant function of MuRF2 and MuRF3 is important for maintenance of skeletal muscle and cardiac structure and function in vivo. | yes |
27,516,377 | Does activation of Serotonin 2C Receptors in Dopamine Neurons inhibit Binge-like Eating in Mice? | {
"contexts": [
"Neural networks that regulate binge eating remain to be identified, and effective treatments for binge eating are limited.",
"We combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, and chemogenetic approaches to investigate the functions of 5-hydroxytryptamine (5-HT) 2C rece... | We identified the 5-HT | yes |
27,496,626 | Does systemic-Pulmonary Shunt facilitate the Growth of the Pulmonary Valve Annulus in Patients With Tetralogy of Fallot? | {
"contexts": [
"Transannular patching (TAP) frequently accompanies primary repairs (PRs) in symptomatic neonates with tetralogy of Fallot (TOF). If a systemic-pulmonary shunt (SPS) facilitates the growth of the pulmonary valve annulus (PVA), patients with a marginally small PVA could benefit from a staged repair... | SPS facilitates outgrowth of the PVA over somatic growth in patients with TOF. However, preservation of the PVA may not be achieved on staged repair if the initial PVA is too small. | yes |
27,509,369 | Is diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma Independently Associated with Intravesical Recurrence after Radical Nephroureterectomy? | {
"contexts": [
"To determine the effect of diagnostic ureteroscopy on intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterec¬tomy (RNU).",
"We conducted a retrospective analysis of 664 patients who were treated with RNU for UTUC from June 2000 to Decembe... | Diagnostic ureteroscopy is independently associated with intravesical re¬currence after radical nephroureterectomy. | yes |
27,496,865 | Is progression of EGFR mutant lung adenocarcinoma driven by alveolar macrophages? | {
"contexts": [
"Lung adenocarcinomas with mutations in the epidermal growth factor receptor (EGFR) have unprecedented initial responses to targeted therapy against the EGFR. Over time, however, these tumors invariably develop resistance to these drugs. We set out to investigate alternative treatment approaches f... | Because of the inevitability of failure of targeted therapy in EGFR mutant NSCLC, these data suggest that therapeutic strategies targeting alveolar macrophages in EGFR mutant NSCLC have the potential to mitigate progression and survival in this disease. | yes |
27,508,345 | Is hyperglycemia associated with increased risk of patient delay in pulmonary tuberculosis in rural areas? | {
"contexts": [
"Excessive time between the first presentation of symptoms of pulmonary tuberculosis (PTB) and diagnosis contributes to ongoing transmission and increased risk of infection in the community, as well as to increased disease severity and higher mortality. People with type 2 diabetes mellitus (T2DM) ... | Patient delay appears to be a serious problem in this rural area with a high prevalence of tuberculosis. Hyperglycemia is independently associated with an increased probability of patient delay, which, in turn, may result in more serious clinical manifestations. | yes |
27,494,911 | Is oral decontamination with aminoglycosides associated with lower risk of mortality and infections in high-risk patients colonized with colistin-resistant , KPC-producing Klebsiella pneumoniae? | {
"contexts": [
"Invasive infections caused by KPC-producing Klebsiella pneumoniae (KPCKP) are associated with very high mortality. Because infection is usually preceded by rectal colonization, we investigated if decolonization therapy (DT) with aminoglycosides had a protective effect in selected patients.",
... | Intestinal decolonization with aminoglycosides is associated with a reduction in crude mortality and KPCKP infections at 180 days after initiating treatment. | yes |
27,510,910 | Does mST1 coordinately regulate autophagy and apoptosis in diabetic cardiomyopathy in mice? | {
"contexts": [
"Diabetic cardiomyopathy (DCM) is associated with suppressed autophagy and augmented apoptosis in the heart although the interplay between the two remains elusive. The ability of mammalian sterile 20-like kinase 1 to regulate both autophagy and apoptosis prompted us to investigate it as a possible... | Mst1 knockout restores autophagy and protects against apoptosis in cardiomyocytes, en route to the rescue against DCM. | yes |
27,497,670 | Does sulforaphane prevent Neuronal Apoptosis and Memory Impairment in Diabetic Rats? | {
"contexts": [
"To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment in diabetic rats.",
"Thirty male rats were randomly divided into normal control, diabetic model and SFN treatment groups (N = 10 in each group). Streptozotocin (STZ) was applied to establis... | SFN could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat. The possible mechanism was related to the regulation of neurotropic factors and Akt/GSK3β pathway. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.