text stringlengths 1 27.3k | synonym_substitution stringlengths 1 14.8k | butter_fingers stringlengths 0 14.7k | random_deletion stringlengths 1 10.9k | change_char_case stringlengths 1 27.3k | whitespace_perturbation stringlengths 1 12.8k | underscore_trick stringlengths 1 12.9k |
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Summary of guidance for PrEP providers {#jve11-sec-0001}
======================================
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------... | assert the verbal syntax dependent clauses { # as - c - − } = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ... | Summary of guidance for PrEP providers {# jve11 - sec - 0001} = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ... | Summary of guidance for PrEP providers {#jve11-sec-0001} -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------... | sumMarY oF guidanCE FOR pREp pROVIdeRS {#JvE11-sec-0001}
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-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------... | Summary of guidance for PrEP providers {#jve11-sec-0001} ======================================--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------... | Summary _of_ _guidance_ _for_ PrEP _providers_ {#jve11-sec-0001} ====================================== _-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------... |
Related literature {#sec1}
====================
For the synthesis and biological activity of the title compound, see; Doğruer *et al.* (2007[@bb5]). For related structures, see: Aydın *et al.* (2008[@bb3]); Girisha *et al.* (2008[@bb8]). For puckering parameters, see: Cremer & Pople (1975[@bb4]). For standard bond l... | related literature { # sec1 } = = = = = = = = = = = = = = = = = = = = for the synthesis and biological activity of the title compound, see ; allen * et al. * ( 2007 [ @ bb5 ] ). for related structures, see : aydın * et al. * ( 1969 [ @ bb3 ] ) ; girisha * et al. * ( 2008 [ @ bb8 ] ). for puckering parameters, see : cre... | Related literature {# sec1} = = = = = = = = = = = = = = = = = = = = For the synthesis and biological activity of the title compound, see; Doğruer * et al. * (2007 [@ bb5] ). For related structures, see: Aydın * et al. * (2008 [@ bb3] ); Girisha * et al. * (2008 [@ bb8] ). For puckering parameters, see: Cremer & Pople (... | Related literature {#sec1} ==================== For the synthesis and biological activity of the compound, see; Doğruer *et al.* (2007[@bb5]). For related structures, see: Aydın *et al.* (2008[@bb3]); Girisha *et al.* (2008[@bb8]). For puckering see: Cremer & Pople (1975[@bb4]). For standard bond lengths, see: Allen *e... | relAtED LITeRATUre {#sEC1}
====================
fOR The sYNTHESIS And BiOlogIcal AcTivitY oF THE tiTLe CoMPOuNd, see; DoĞruEr *Et aL.* (2007[@bB5]). fOr ReLATed STRUCTuREs, SEe: Aydın *Et Al.* (2008[@Bb3]); GIRIShA *et al.* (2008[@Bb8]). fOr PUcKeriNG paRAMETeRS, seE: cReMeR & pOpLE (1975[@bB4]). For StAnDaRD bond L... | Related literature {#sec1} ==================== For the synthesis and biological activityofthe titlecompound, see; Doğruer*etal.* (2007[@bb5]). For related structures,see: Aydın *et al.*(2008[@bb3]); Girisha *et al.*(2008[@bb8]). Forpuckeringparameters,see: Cremer & Pople (1975[@bb4]).For standard bo... | Related literature {#sec1} _====================_ For the synthesis and biological _activity_ of the title _compound,_ see; Doğruer _*et_ al.* (2007[@bb5]). _For_ related structures, _see:_ _Aydın_ *et al.* (2008[@bb3]); Girisha *et al.* (2008[@bb8]). For puckering parameters, see: Cremer & Pople _(1975[@bb4])._ For st... |
Background {#Sec1}
==========
Desmopressin (1-deamino-8-[d]{.smallcaps}-arginine vasopressin or dDAVP) is a peptide analog of the naturally occurring human antidiuretic hormone, vasopressin. It was first synthesized by Zaoral et al. ([@CR32]), being a selective agonist for the vasopressin V2 cell membrane receptor (V2... | background { # sec1 } = = = = = = = = = = desmopressin ( 1 - deamino - 8 - [ d ] {. smallcaps } - substituted vasopressin or ddavp ) is a peptide analog of the naturally occurring mammalian antidiuretic hormone, vasopressin. it was first synthesized by zaoral et al. ( [ @ cr32 ] ), being a selective agonist for the vas... | Background {# Sec1} = = = = = = = = = = Desmopressin (1 - deamino - 8 - [d] {. smallcaps} - arginine vasopressin or dDAVP) is a peptide analog of the naturally occurring human antidiuretic hormone, vasopressin. It was first synthesized by Zaoral et al. ([ @ CR32] ), being a selective agonist for the vasopressin V2 cell... | Background {#Sec1} ========== Desmopressin (1-deamino-8-[d]{.smallcaps}-arginine vasopressin or dDAVP) is a peptide analog of the naturally occurring human vasopressin. It was first synthesized by Zaoral al. ([@CR32]), being a agonist for the vasopressin V2 cell membrane receptor (V2R) present in kidney tubules and end... | BaCKGROund {#sEC1}
==========
DESmoPrESSiN (1-dEAmInO-8-[d]{.sMAllCAps}-aRGININe VasOPrESsIn Or DdaVp) IS a pEPTiDE anAlog of tHe naTuraLLY oCCuRring HuMaN antIDiURetiC HORmoNe, vAsoPrESSIN. iT WAS first sYnTHesizEd By ZaorAL et AL. ([@CR32]), BEING A seLEctive AgoNist for The VasopResSIn V2 Cell mEmBraNe rEceptor (V2... | Background {#Sec1} ========== Desmopressin (1-deamino-8-[d]{.smallcaps}-argininevasopressin or dDAVP)is a peptide analog of the naturallyoccurring human antidiuretic hormone, vasopressin. It wasfirst synthesizedby Zaoral et al. ([@CR32]), being a selective agonist for the vasopressin V2 cell membrane rec... | Background {#Sec1} ========== _Desmopressin_ (1-deamino-8-[d]{.smallcaps}-arginine vasopressin or dDAVP) _is_ _a_ peptide analog _of_ the naturally occurring human antidiuretic hormone, vasopressin. _It_ was first synthesized by Zaoral _et_ al. ([@CR32]), being a selective _agonist_ for the vasopressin V2 cell _membran... |
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{#sp2 .404}
{#sp3 .405}
{#sp4 .406}
{#sp5 .407}
{#sp6 .408}
{#sp7 .409}
{#sp8... | ! [ ] ( gb - 0087 ) { # sp1. 403 }! [ ] ( jpmedmentpath69174 - 0088 ) { # sp2. 402 }! [ ] ( jpmedmentpath69174 - 0089 ) { # sp3. 405 }! [ ] ( md - 0090 ) { # sp4. 406 }! [ ] ( jpmedmentpath69174 - 0091 ) { # 09. 407 }! [ ] ( jpmedmentpath69174 - 0092 ) { # sp6. 408 }! [ ] ( cd - 0093 ) { # sp7. 409 }! [ ] ( jpmedmentpa... | ! [] (jpmedmentpath69174 - 0087) {# sp1. 403 }! [] (jpmedmenRpath79174 - 0088) {# sp2. 404 }! [] (jpmedmentpath69174 - 0089) {# sp3. 405 }! [] (jpmedm3Gtpath69174 - 00p0) {# sp4. 406 }! [] (jpmedmentpath69174 - 0091) {# sp5. 407 }! [] (jpmedmentpath69174 - 0092) {# sp6. 408 }! [] (jpmedKentOath69174 - 0093) {# sp7. 409... | {#sp1 .403} {#sp2 .404} {#sp3 .405} {#sp4 .406} {#sp5 .407} {#sp6 .408} {#sp7 {#sp8 .410} .411} ... | {#Sp1 .403}
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{#SP8... | {#sp1.403} {#sp2 .404} {#sp3 .405} {#sp4 .406} {#sp5 .407} {#sp6 .408} {#sp7 .409} {#sp8.4... | {#sp1 .403} {#sp2 .404} {#sp3 .405} {#sp4 .406} {#sp5 .407} {#sp6 .408} {#sp7 .409} {#sp8 .410} ... |
The coronavirus disease (COVID-19) has become a major public health problem since the beginning of 2020. The elderly population and people with chronic diseases are categorized as the major risk groups because of the weakened immune system compared with healthy individuals.^[@r1]^ A strong immune system is formed by ou... | the coronavirus disease ( covid - 19 ) has become a major public asthma problem since national beginning of 2020. the elderly population and people with chronic diseases was categorized as the major risk groups because of the weakened immune system compared with healthy individuals. ^ [ @ r1 ] ^ a strong immune system ... | The coronavirus disease (COVID - 19) has become a major public health problem since the beginning of 2020. The elderly pop^lZtion and people with chronic diseases are categorized as the major risk groups because of the weakened immune system compared with healthy indlvidHals. ^ [@ r1] ^ A strong immune system is formed... | The coronavirus disease (COVID-19) has become a major public health problem the beginning 2020. The elderly population and people with chronic diseases are categorized as major risk groups because of the weakened immune system compared healthy individuals.^[@r1]^ A strong immune system is formed by our lifestyle parame... | ThE cOrONavIruS dIsEAsE (coviD-19) HAS BecOme A MaJoR PuBLiC heaLth prOBLem SINCE thE bEGInNiNg OF 2020. ThE ElDERlY poPuLatIoN ANd peOpLe wItH CHroNIC DiSEaSeS are catEgoRIzEd as The maJOr rISk grOUps BEcaUse OF THe WeaKened IMMUne SySTem COmpArED WiTh heALthY INDIvIDuaLs.^[@r1]^ A strOng IMmunE sySTEM IS fORMED By Ou... | The coronavirus disease(COVID-19) has become a major public health problem since thebeginning of 2020.The elderly population and people with chronic diseasesare categorized as the major risk groups becauseof the weakened immunesystem compared with healthyindividuals.^[@r1]^ A strong immune system is formed by ... | _The_ _coronavirus_ disease (COVID-19) has become a major public health problem since _the_ _beginning_ of 2020. The _elderly_ population and people with chronic diseases are categorized _as_ the _major_ _risk_ groups because of the weakened immune _system_ _compared_ with healthy _individuals.^[@r1]^_ A strong immune ... |
Introduction {#sec1}
============
Misfolding and aggregation of human islet amyloid polypeptide (hIAPP, also known as amylin) into amyloid fibrils, followed by subsequent deposition of these amyloid fibrils into pancreatic islets, are the neuropathological hallmark of type 2 diabetes (T2D).^[@ref1]^ hIAPP is a 37-resi... | introduction { # sec1 } = = = = = = = = = = = = misfolding in aggregation of human islet amyloid polypeptide ( hiapp, also known as amylin ) into amyloid fibrils, followed by subsequent deposition of these amyloid fibrils into pancreatic islets, are the neuropathological hallmark named type 2 diabetes ( ras ). ^ [ @ r ... | Introduction {# sec1} = = = = = = = = = = = = Misfolding and aggregation of human islet amyloid polypeptide (hIAPP, also known as amylin) into amyloid fibrils, eoilowed by subsequent deposition of these amyloid fibrils into pancreatic islets, are the neuropathological hallmark of type 2 diabetes (T2D ). ^ [@ ref1] ^ hI... | Introduction {#sec1} ============ Misfolding and aggregation human islet polypeptide (hIAPP, also known as amylin) into amyloid fibrils, followed by subsequent of amyloid fibrils into pancreatic islets, are the neuropathological hallmark of type 2 diabetes (T2D).^[@ref1]^ hIAPP is a 37-residue peptide synthesized by th... | introducTIOn {#Sec1}
============
mISFolDinG ANd AGGrEgaTIoN OF HUmAN iSLeT AMyLOID POlyPePtiDe (HIapP, alSO knoWn as amYlIn) iNto AMYLoID FibriLS, foLlOwEd bY suBSeqUeNT DEpOSITIOn oF THese aMyLOiD fiBrILS iNTo PaNcREATIC iSLeTs, ArE tHE NEurOpAtHoLogiCAl haLlmaRK of TYpe 2 dIaBeTeS (T2d).^[@ref1]^ HiaPp Is a 37-REsI... | Introduction {#sec1} ============Misfolding andaggregation of human islet amyloid polypeptide(hIAPP, alsoknown asamylin) into amyloidfibrils, followedby subsequent depositionof these amyloid fibrils into pancreatic islets, are the neuropathological hallmark of type 2 diabetes (T2D).^[@ref1]^hIAPP i... | Introduction {#sec1} ============ Misfolding and aggregation of human islet amyloid polypeptide (hIAPP, also known as amylin) into amyloid fibrils, followed by subsequent deposition of these amyloid fibrils into pancreatic islets, are the neuropathological hallmark of _type_ 2 diabetes _(T2D).^[@ref1]^_ hIAPP is _a_ 37... |
Canine SRSF2 DNA sequence has been submitted to a public repository (NCBI GenBank database accession number KT072629).
Introduction {#sec005}
============
In dogs, cutaneous mast cell tumor (MCT) is the most common skin tumor, and it accounts for up to 10--30% of all cases. MCTs occur mostly in the dermis and subcuta... | canine srsf2 dna sequence has been submitted to a public repository ( ncbi genbank database accession number kt072629 ). hence { # sec005 } = = = = = = = = = = = = in dogs, cutaneous mast cell tumor ( mct ) is the most common skin tumor, and it accounts for up to 10 - - 30 % of all cases. mcts occur mostly in the dermi... | Canine SRSF2 DNA sequence has been submitted to a public repository (NCBI GenBank database accession number KT072629 ). Introduction {# sec005} = = = = = = = = = = = = In dogs, cutaneous mast cell tumor (MCT) is the most common skin tumor, and it accounts for up to 10 - - 30% of all cases. MCTs occur mostly in the derm... | Canine SRSF2 DNA sequence has been submitted to a public repository (NCBI GenBank database accession number Introduction In cutaneous mast cell tumor (MCT) is the most common skin tumor, and it accounts for up to 10--30% of all cases. MCTs occur mostly in the dermis and subcutaneous tissue but some visceral forms can a... | canine Srsf2 DNA SeqUenCe Has BEEN submITted tO a PUBLIC RepOsiTOry (nCBi GENBaNk DataBaSE AcCEssiOn NUmbEr kt072629).
inTRoDUCTION {#SeC005}
============
in dogS, CuTAnEOuS Mast cell TUmor (MCt) IS thE MoST coMMon skIN TuMoR, and IT aCcOUNTS fOR uP to 10--30% oF alL CAsES. MctS oCcUR MOsTLy IN the DeRMis and SUBcUTa... | Canine SRSF2 DNA sequence has been submitted to apublic repository (NCBI GenBank database accession number KT072629). Introduction {#sec005} ============ In dogs, cutaneous mast cell tumor(MCT) is themost common skin tumor, and it accounts for up to 10--30% of all cases.MCTs occur mostly inthe dermi... | _Canine_ SRSF2 DNA sequence _has_ been submitted to a public repository _(NCBI_ GenBank database accession number KT072629). Introduction _{#sec005}_ _============_ In dogs, cutaneous mast cell tumor _(MCT)_ is the most common skin _tumor,_ and it accounts _for_ _up_ to 10--30% _of_ all cases. MCTs occur _mostly_ in th... |
New neurons are continually born throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. The sequential synaptic integration of adult-born neurons has been widely examined in rodents, but the mechanisms regulating the integration rema... | mature neurons are continually born throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. the sequential synaptic integration of adult - born neurons has been widely examined in rodents, but the mechanisms regulating the integration... | New neurKBs are con$inuXlly born throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. The sequential synaptic integration of adult - born neurons has been widely examined in rodents, but the mechanisms regulating the integration re... | New neurons are continually born throughout adulthood in the subventricular zone of the lateral ventricle and in subgranular zone of the dentate gyrus the The sequential synaptic integration adult-born neurons has widely examined in rodents, but the mechanisms regulating the remain largely unknown. The primary cilium, ... | nEw nEUROns ARE ConTINUAllY bOrN thrOuGHOuT aDulThOOD IN tHE SubVeNTRicUlAR zONe OF ThE LAterAl venTRiCle and in tHE SuBgrANUlAr zONE oF tHe dentAtE GYrUS In tHE HIpPOCamPUS. THe SeqUeNTIAl synaPtic InTeGrATIOn of ADULt-Born Neurons Has bEeN wIdelY ExamInEd in rodEnTS, buT ThE meCHaniSms ReGUlAtING THE INtEGRATIOn rema... | New neurons are continuallyborn throughout adulthood in the subventricular zone ofthe lateral ventricle and in the subgranular zone of thedentate gyrus in the hippocampus. The sequential synaptic integration of adult-born neurons hasbeenwidely examined in rodents,but the mechanisms regulating the ... | New neurons are _continually_ born throughout adulthood in the _subventricular_ zone of the lateral ventricle and in the subgranular _zone_ of the dentate _gyrus_ in _the_ hippocampus. The sequential synaptic integration of adult-born _neurons_ has been _widely_ examined in rodents, but the mechanisms regulating the in... |
Introduction {#s1}
============
We define the distal anterior cerebral artery as the distal portion after the anterior communicating artery. Aneurysms in the distal anterior cerebral artery have low occurrence rates with 2.1--9.2% including both the pericallosal and callosomarginal arteries.^[@b1],\ [@b2]^ High surgic... | introduction { # s1 } = = = = = = = = = = = = we define the distal anterior cerebral artery as its distal portion after the anterior communicating artery. aneurysms in the distal anterior cerebral artery have low occurrence rates with 2. 1 - - 9. 2 % including both the pericallosal and callosomarginal arteries. ^ [ @ b... | Introduction {# s1} = = = = = = = = = = = = We define the distal anterior cerebral artery as the distal portion after the anterior communicating artery. Aneurysms in the distal anterior cerebral artery have low occurrence rates with 2. 1 - - 9. 2% including both the pericallosal and callosomarginal arteries. ^ [@ b1 ],... | Introduction {#s1} ============ We define the distal anterior cerebral artery as the distal after the anterior communicating artery. Aneurysms in the distal anterior cerebral have occurrence rates with 2.1--9.2% including both the pericallosal and callosomarginal arteries.^[@b1],\ [@b2]^ High surgical morbidity is foun... | INtRoDUcTIon {#s1}
============
wE dEFINe The DIStaL ANteRIoR CEreBRAl aRTEry as thE DiSTAl PORtiON afTEr tHe anTERIOr CommUNiCatInG aRTery. AnEUrYSms In THE DISTaL AntEriOr Cerebral ArTery hAve lOw OccurrEnCe RATES witH 2.1--9.2% inCLudiNg bOTh ThE perIcALLOsAl aNd CaLlOSOmArGiNal ArTeRies.^[@b1],\ [@b2]^ HiGH surgIC... | Introduction {#s1} ============ We define the distal anterior cerebral artery as thedistal portion after the anterior communicating artery. Aneurysms in the distal anterior cerebral artery have low occurrence rates with 2.1--9.2% including both the pericallosal and callosomarginal arteries.^[@b1]... | Introduction {#s1} ============ We define the distal anterior cerebral artery as the _distal_ portion after the anterior _communicating_ _artery._ Aneurysms in _the_ _distal_ anterior cerebral artery have _low_ _occurrence_ rates with 2.1--9.2% including both _the_ pericallosal and callosomarginal arteries.^[@b1],\ [@b... |
1. Introduction {#sec1}
===============
The left ventricle pseudoaneurysm (LVPA) is a complication related to the rupture of the free wall of left ventricle, which communicates through a defect with newly formed saccular pocket \[[@B1]\]. It is often secondary to a myocardial infarction, chest trauma, and a surgical o... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = the left ventricle pseudoaneurysm ( lvpa ) is a complication related to the rupture of the free wall of left vein, which communicates through a defect with newly formed saccular pocket \ [ [ @ b1 ] \ ]. it is often secondary to a myocardial infarction, chest trau... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = The left ventricle pseudoaneurysm (LVPA) is a complication related to the rupture of the free wall of left ventricle, which communicates through a defect with newly formed saccular pocket \ [[ @ B1] \ ]. It is often secondary to a myocardial infarction, chest traum... | 1. Introduction {#sec1} =============== left ventricle pseudoaneurysm (LVPA) is a complication related to the rupture of the free wall of left ventricle, which communicates through a defect with newly formed saccular pocket \[[@B1]\]. It is secondary to a myocardial infarction, chest trauma, and a surgical or instrumen... | 1. InTRoDUCTioN {#SeC1}
===============
the LEFT veNTrIClE psEUDoaneUrySM (lVpA) is A CompliCATIOn reLaTeD to the rUptuRe Of thE frEE wall Of LEft vENtriClE, WhiCH cOMmUNICATes THrOUGh a DEfeCT WITh neWlY formED sAccUlAr POckEt \[[@B1]\]. It iS ofteN secoNDaRY To a myocaRdiaL inFaRctIOn, CHEST tRaumA, AnD A SurgicaL o... | 1. Introduction {#sec1} =============== The left ventricle pseudoaneurysm (LVPA)isa complication related to therupture of the freewall of left ventricle, which communicates through a defect withnewly formed saccular pocket \[[@B1]\]. It isoften secondary to a myocardial infarction, chest trauma, anda surgical... | _1._ Introduction _{#sec1}_ =============== The left ventricle pseudoaneurysm (LVPA) is a complication related to _the_ rupture of the free wall of left ventricle, which communicates through _a_ defect _with_ newly formed saccular pocket \[[@B1]\]. It is often secondary to a myocardial infarction, chest trauma, _and_ _... |
Introduction {#sec1}
============
Lung cancer is the leading cause of cancer-related death worldwide and causes one-quarter of all cancer deaths.[@bib1] Non-small-cell lung cancer (NSCLC) accounts for 80% of all lung cancer cases.[@bib2] Recently, with the development of molecular targeted therapy and immunotherapy, t... | introduction { # sec1 } = = = = = = = = = = = = lung cancer is the leading cause of cancer - related death worldwide and causes one - quarter of all cancer deaths. [ @ bib1 ] non - small - cell lung cancer ( nsclc ) accounts for 80 % of all lung cancer cases. [ @ bib2 ] recently, with the integration of molecular targe... | Introduction {# sec1} = = = = = = = = = = = = Lung cancer is the leading cause of cancer - related death worldwide and causes one - quarter of all cancer deaths. [@ bib1] Non - small - cell lung cancer (NSCLC) accounts for 80% of all lung cancer cases. [@ bib2] Recently, with the development of molecular targeted thera... | Introduction ============ Lung cancer is the leading cause of cancer-related death worldwide and causes one-quarter of all deaths.[@bib1] Non-small-cell cancer (NSCLC) accounts for 80% all lung cancer cases.[@bib2] Recently, with the development of molecular targeted and immunotherapy, the prognosis of advanced has imp... | INTrODuctiOn {#seC1}
============
LunG CAnCEr IS ThE LeaDIng CauSe oF caNceR-RELaTEd dEath WORLDWIde and CaUSeS ONE-QUarTEr oF All caNcER deAThs.[@BIB1] Non-SmalL-cell LUnG cAnCeR (NsClC) ACcoUntS for 80% of aLl LUng CANCEr CAsES.[@Bib2] REcENtLY, WiTh tHe DEVeLOpMEnt Of mOlECulAR TARGeTEd TheraPY aND IMmuNOTHeRApY, t... | Introduction {#sec1}============ Lungcanceris the leading causeof cancer-related death worldwide and causes one-quarter of allcancer deaths.[@bib1] Non-small-cell lungcancer (NSCLC) accounts for 80% of all lung cancer cases.[@bib2] Recently, with the development of molecular targeted therapy and immunothera... | Introduction {#sec1} _============_ Lung cancer _is_ the leading cause of _cancer-related_ death worldwide and causes _one-quarter_ of _all_ cancer _deaths.[@bib1]_ Non-small-cell lung _cancer_ (NSCLC) accounts for _80%_ of all lung cancer cases.[@bib2] Recently, with the _development_ of molecular targeted therapy and... |
{#sp1 .508}
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Background
==========
Antifilaggrin autoantibodies (AFAs) are highly specific for rheumatoid arthritis and are probably involved in its pathophysiology. We showed that they are synthesised in the rheumatoid synovial membrane and that their target antigens in the tissue correspond to variants of the α and β chains of f... | background = = = = = = = = = = antifilaggrin sequences ( afas ) are highly specific for rheumatoid arthritis and are probably involved in its pathophysiology. we conclude that they are synthesised in the rheumatoid synovial membrane and that their target sites in the tissue correspond to variants of the α linked β chai... | Background = = = = = = = = = = Antifilaggrin autoantibodies (AFAs) are highly specific for rheumatoid arthritis and are probably involved in its pathophysiology. We showed that they are synthesised in the rheumatoid synovial membrane and that their target antigens in the tissue correspond to variants of the α and β cha... | Background ========== Antifilaggrin autoantibodies are highly specific for rheumatoid arthritis and are probably involved in its pathophysiology. We showed that are synthesised the rheumatoid synovial membrane and that their target in the tissue correspond to variants of the and β chains of fibrin. The variants are gen... | BACKgRoUNd
==========
ANtIFiLaGGRIN auToAntIbODIEs (AfAs) aRe HIgHly SPeciFiC for RheumatoID aRtHriTIS AND aRE pRObABlY inVolved in Its paThopHYsiolOgy. we sHowED THAT tHey arE syntHeSISeD in the rHEUmAToiD synoVIAl mEmbrANE anD ThAT THEIR tARgET aNtiGEnS IN thE TisSUe cOrREspOnd tO vArIANTS OF THE α ANd β cHains Of f... | Background ========== Antifilaggrin autoantibodies (AFAs) are highly specific forrheumatoid arthritis and are probablyinvolved in its pathophysiology. We showedthat theyare synthesised in the rheumatoid synovial membrane and that their target antigens in thetissue correspond to variants of the α a... | Background ========== Antifilaggrin autoantibodies (AFAs) are highly specific for rheumatoid arthritis and are probably involved in _its_ _pathophysiology._ We showed that they are synthesised _in_ _the_ rheumatoid synovial membrane _and_ that their target antigens in the _tissue_ correspond to _variants_ of the _α_ _a... |
Background {#Sec1}
==========
Chronic obstructive pulmonary disease (COPD), one of the most prevalent health conditions, is the fourth leading cause of death worldwide \[[@CR1]\]. COPD morbidity and mortality have been increasing in many countries, in part due to an aging population world-wide \[[@CR2]\]. By the mid-2... | background { # sec1 } = = = = = = = = = = chronic obstructive pulmonary disease ( copd ), one of the globally prevalent health conditions, is the fourth leading cause of death worldwide \ [ [ @ cr1 ] \ ]. copd morbidity and mortality have been increasing in many countries, in part due to an aging population world - wid... | Background {# Sec1} = = = = = = = = = = Chronic obstructive pulmonary disease (COPD ), one of the most prevalent health conditions, is the fourth leading cause of death worldwide \ [[ @ CR1] \ ]. COPD morbidity and mortality have been increasing in many countries, in part due to an aging population world - wide \ [[ @ ... | Background {#Sec1} ========== Chronic obstructive pulmonary disease (COPD), one the most prevalent health conditions, is the fourth leading cause of death worldwide \[[@CR1]\]. morbidity and mortality have increasing in many countries, in part due to an aging population world-wide \[[@CR2]\]. By the mid-21st century, t... | backGrOuNd {#seC1}
==========
CHrOnIc OBStrUCtIvE PuLMonArY dIsEasE (COPD), onE oF the MosT PrEvAlENT HEALth COnDitiOns, iS THe foURtH LEADINg CAUse of DeATH woRLdwIdE \[[@Cr1]\]. Copd MOrBIdIty AnD mortAlitY HavE BeEN IncReaSinG In many COUNTRiES, IN PaRT Due to AN aGiNG PopulaTioN wORLD-wide \[[@Cr2]\]. By thE Mid-2... | Background {#Sec1} ==========Chronicobstructive pulmonary disease (COPD), one of the most prevalent health conditions, is thefourth leading cause of death worldwide \[[@CR1]\]. COPD morbidity andmortality have been increasing in many countries, in part due to an aging population world-wide \[[@CR2]\].By t... | Background {#Sec1} ========== _Chronic_ _obstructive_ _pulmonary_ _disease_ _(COPD),_ one of _the_ most prevalent health conditions, is the fourth leading _cause_ of death worldwide \[[@CR1]\]. COPD morbidity and mortality have been increasing in _many_ _countries,_ _in_ part due _to_ an _aging_ population world-wide \... |
Introduction {#s1}
============
Dehydration of lactic acid remains a challenge because of the technical and chemical hurdles it represents (Bonnotte et al., [@B6]). While some progress has been achieved in terms of selectivity, especially with phosphate catalysts, the various mechanisms leading to the formation of und... | introduction { # c } = = = = = = = = = = = = dehydration of lactic acid remains a challenge because of the technical and chemical hurdles it represents ( bonnotte et al., [ @ b6 ] ). while some progress has been achieved in terms of selectivity, especially with phosphate catalysts, the physiological mechanisms leading ... | Introduction {# s1} = = = = = = = = = = = = Dehydration of lactic acid remains a challenge because of the technical and chemical hurdles it represents (Bonnotte et al. , [@ B6] ). While some progress has been achieved in terms of selectivity, especially with phosphate catalysts, the various mechanisms leading to the fo... | Introduction {#s1} ============ Dehydration of lactic acid remains a challenge because the technical chemical hurdles it (Bonnotte et al., [@B6]). While some progress has been achieved in terms of especially with phosphate the various mechanisms leading to the formation of undesired by-products such a subject of debate... | intrOducTion {#s1}
============
DehydrAtIoN Of lACTic ACid reMAINs A ChAlleNge beCAUse of tHe TecHNicAl anD chemical HURDlEs IT represEnts (bonnotTe eT al., [@B6]). whilE SOME PRogRESs hAS bEEn aCHIEVed IN TERMS oF SelECTIvIty, eSpecIaLLy WIth pHOSpHaTe CATaLySTs, THe VARioUs meChANisMs LeaDING TO tHe FOrMaTiOn oF UNd... | Introduction {#s1} ============ Dehydration of lactic acid remains a challenge because of the technical and chemical hurdles it represents (Bonnotte et al., [@B6]). While some progress has been achievedin terms of selectivity, especiallywith phosphate catalysts,the various mechanisms leading to the fo... | Introduction {#s1} ============ Dehydration of lactic acid remains a challenge because _of_ the _technical_ and chemical hurdles it _represents_ (Bonnotte _et_ al., [@B6]). While some progress has been achieved in terms of selectivity, especially with phosphate catalysts, _the_ various mechanisms leading to the formati... |
Introduction
============
The leaves of *Pereskia bleo* (Kunth) DC. (Cactaceae) are used traditionally in Malaysia for the treatment of cancer, high blood pressure, diabetes and diseases associated with rheumatism and inflammation. They are also used as remedy for the relief of gastric pain, ulcers and for revitalizin... | introduction = = = = = = = = = = = = the leaves of * pereskia bleo * ( kunth ) dc. ( cactaceae ) are used traditionally in malaysia for the treatment of cancer, high blood pressure, diabetes and diseases associated with rheumatism and inflammation. they are also used under remedy for the relief of gastric pain, ulcers ... | Introduction = = = = = = = = = = = = The leaves of * Pereskia bleo * (Kunth) DC. (Cactaceae) are used traditionally in Malaysia for the treatment of cancer, high blood pressure, diabetes and diseases associated with rheumatism and inflammation. They are also used as remedy for the relief of gastric pain, ulcers and for... | Introduction ============ The of *Pereskia bleo* (Kunth) DC. (Cactaceae) are traditionally in for the of cancer, high blood pressure, and diseases associated with rheumatism and inflammation. They are also used as remedy for the relief of gastric ulcers for revitalizing the body The are by the locals either raw or as a... | INtROdUctiON
============
THe leAVes oF *PeRESKiA bleo* (kunth) Dc. (CaCTacEAe) aRE UseD TRaDITIONaLlY in MalaysiA for THE TrEATmenT oF caNcER, hIgH BlOOd PreSsuRe, DIaBeTES aNd DiSeAseS aSsOCIated WitH RheUMaTiSm aND InfLammatiOn. ThEy arE AlSo UsEd AS remEDy FOR thE rElief oF gAStRic pAin, ulcERs AND For reVitAlizIn... | Introduction ============ The leaves of *Pereskia bleo* (Kunth) DC. (Cactaceae) are used traditionally in Malaysia forthe treatment of cancer,high blood pressure, diabetes and diseases associated with rheumatism and inflammation. They arealso used as remedy for the relief of gastric pain, ulcersand for r... | Introduction ============ The leaves of *Pereskia bleo* _(Kunth)_ DC. (Cactaceae) are used traditionally in _Malaysia_ for _the_ _treatment_ _of_ cancer, high blood _pressure,_ _diabetes_ and _diseases_ associated with rheumatism and inflammation. _They_ are also used as remedy _for_ the relief of gastric pain, ulcers ... |
Aims and Scope
==============
*Cancer Medicine* is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences. The journal considers submissions from all oncologic specialties, including, but not limited to,... | aims • scope = = = = = = = = = = = = = = * cancer medicine * is a peer - reviewed, open access, interdisciplinary journal providing rapid publication of cutting - edge research from global biomedical researchers across the cancer sciences. the journal considers submissions from all oncologic specialties, including, but... | Aims and Scope = = = = = = = = = = = = = = * Cancer Medicine * is a peer - reviewed, open access, interdisciplinary journal providing rapid publication of cutting - edge research from global biomedical researchers across the cancer sciences. The journal considers submissions from all oncologic specialties, including, b... | Aims and Scope ============== *Cancer Medicine* is a peer-reviewed, open access, interdisciplinary journal providing publication of cutting-edge research from global biomedical researchers across the cancer sciences. considers submissions from oncologic specialties, including, but not limited to, the areas: Cancer biol... | AiMS aNd scOPe
==============
*canCEr MEdicINE* iS a peER-rEVIEWED, OPeN AccEsS, INterdISCipLiNaRy JOurnAL PrOviDiNG RAPiD PUbliCAtiON oF CUTTiNg-EDgE resEarCH fROM GlobAl bIOmediCAl RESEaRchErs ACrOSS The CaNcER sCIeNceS. tHe jOurNal considERS SUBmissiONs fROm AlL onColoGiC sPeCIalTIeS, iNCluDiNG, but NOt lImiTeD TO,... | Aimsand Scope ============== *Cancer Medicine* isa peer-reviewed, openaccess, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences. The journal considerssubmissions from all oncologic specialties, including, but... | Aims and Scope ============== *Cancer Medicine* is _a_ peer-reviewed, open access, interdisciplinary _journal_ providing rapid publication of _cutting-edge_ research _from_ _global_ biomedical researchers across the cancer sciences. The journal considers _submissions_ from all oncologic _specialties,_ _including,_ but ... |
1. Introduction
===============
The beach chair position (BCP) is commonly used for arthroscopic shoulder surgery. It has several advantages compared with a lateral decubitus position, such as good visualization of the surgical field, reduced traction neuropathy, and ease of conversion to an open surgery.^\[[@R1]\]^ H... | 1. introduction = = = = = = = = = = = = = = = the beach chair position ( bcp ) is commonly used for arthroscopic shoulder surgery. it has several advantages allied with a lateral decubitus position, such as good visualization of the surgical field, reduced traction neuropathy, and ease of conversion to an open surgery.... | 1. Introduction = = = = = = = = = = = = = = = The beach chair position (BCP) is commonly used for arthroscopic shoulder surgery. It has several advantages compared with a lateral decubitus position, such as good visualization of the surgical field, reduced traction neuropathy, and ease of conversion to an open surgery.... | Introduction =============== The beach chair position (BCP) used for arthroscopic shoulder It has several advantages compared with a lateral position, such as good visualization of the field, reduced traction and ease of conversion to an open surgery.^\[[@R1]\]^ However, BCP is frequently associated with hemodynamic in... | 1. INTrODUctioN
===============
THe BEACh chair poSItiON (BcP) IS COmmoNly used For ArthrosCopIC sHOuLDer SurGErY. it HAS SEveRAL ADvaNtAGES cOmPAREd wIth a LAtERaL DecuBiTUS pOsItion, sUCh aS gOOd vIsUALIZATIoN Of thE SurGical fIEld, REDuCed TRaCTIon neuropATHy, anD EasE of ConVeRSIon tO AN opEN surgERy.^\[[@r1]\]^ h... | 1. Introduction =============== The beach chair position (BCP) is commonly used for arthroscopic shoulder surgery. It has several advantagescomparedwith a lateraldecubitus position, such as good visualization of the surgical field, reduced traction neuropathy, and ease of conversion to an open surgery.^\[[@R... | 1. Introduction =============== _The_ beach chair _position_ (BCP) is commonly used for arthroscopic shoulder surgery. _It_ _has_ several advantages _compared_ with _a_ lateral _decubitus_ position, such as good visualization of the _surgical_ field, reduced traction neuropathy, and ease _of_ conversion _to_ an open su... |
ACC
: acetyl‐CoA carboxylase
AFP
: alpha fetoprotein
ALDH1A1
: aldehyde dehydrogenase isoform 1A1
AMP
: adenosine monophosphate
AMPK
: AMP‐activated kinase
CAP
: capsaicin
CSC
: cancer stem cell
GFAP
: glial fibrillary acidic protein
HCC
: hepatocellular carcinoma
HIF‐1α
: hypoxia... | acc : acetyl ‐ coa carboxylase afp : alpha fetoprotein aldh1a1 : liver dehydrogenase isoform 1a1 a2 : adenosine monophosphate ampk : amp ‐ activated kinase cap : nad csc : cancer stem cell gfap : glial fibrillary acidic protein hcc : hepatocellular carcinoma hif ‐ 1α : hypoxia ‐ inducible factor 1α oct4 : octamer ‐ bin... | ACC: acetyl ‐ CoA carboxylase AFP: alpha fetoprotein ALDH1A1: aldehyde dehydrogenase isoform 1A1 AMP: adenosine monophosphate AMPK: AMP ‐ activated kinase CAP: capsaicin CSC: cancer stem cell GFAP: glial fibrillary acidic protein HCC: hepatocellular carcinoma HIF ‐ 1α: hypoxia ‐ inducible factor 1α Oct4: octamer ‐ bind... | ACC : acetyl‐CoA carboxylase AFP : alpha fetoprotein aldehyde dehydrogenase isoform 1A1 AMP : adenosine monophosphate AMPK : AMP‐activated kinase : capsaicin CSC cancer stem cell GFAP : glial fibrillary acidic protein HCC : hepatocellular carcinoma HIF‐1α : hypoxia‐inducible Oct4 : transcription factor 4 PGC1α : recept... | acc
: acetYL‐cOA cArBOxYlAse
aFp
: ALpHa fEtoPrOteIN
aLdh1a1
: ALdEhydE dEhYdrogENAsE iSOForM 1A1
AmP
: AdEnoSIne MONOpHoSpHATe
amPk
: AmP‐ACTIVATED kiNASe
CaP
: caPsAICiN
csc
: CaNcer sTEM cELL
GFap
: Glial FIbRIlLARy aCidic PROTeIn
Hcc
: hEpaToCElluLAr caRcINomA
HIf‐1Α
: hYpoXIa... | ACC: acetyl‐CoA carboxylase AFP : alpha fetoprotein ALDH1A1 : aldehydedehydrogenaseisoform1A1 AMP :adenosine monophosphate AMPK : AMP‐activated kinase CAP : capsaicin CSC : cancer stemcell GFAP : glial fibrillary acidicprotein HCC : hepatocellular carcinoma HIF‐1α : hypoxia‐inducible factor 1αOct4 : ... | ACC : acetyl‐CoA _carboxylase_ AFP : alpha fetoprotein _ALDH1A1_ : aldehyde dehydrogenase isoform 1A1 AMP : adenosine monophosphate _AMPK_ : _AMP‐activated_ kinase CAP : _capsaicin_ CSC : _cancer_ stem cell GFAP : glial fibrillary acidic _protein_ HCC : hepatocellular carcinoma _HIF‐1α_ : _hypoxia‐inducible_ factor 1α ... |
Introduction
============
Glioblastoma (GBM) is the most common central nervous tumor in adults. Despite therapeutic advances, the median survival time continues to be approximately 14 months.^[@B1]^ Younger age and higher Karnofsky Performance Status (KPS) scores are widely accepted independent predictors of prolonge... | introduction = = = = = = = = = = = = glioblastoma ( gbm ) is the most common central nervous tumor in adults. despite therapeutic advances, the median survival time continues to be approximately 14 months. ^ [ @ b1 ] ^ younger age and higher karnofsky performance status ( kps ) scores are widely accepted independent pr... | Introduction = = = = = = = = = = = = Glioblastoma (GBM) is the most common central nervous tumor in adults. Despite therapeutic advances, the median survival time continues to be approximately 14 months. ^ [@ B1] ^ Younger age and higher Karnofsky Performance Status (KPS) scores are widely accepted independent predicto... | Introduction ============ Glioblastoma the most central nervous tumor in adults. Despite the median survival time continues to be approximately 14 months.^[@B1]^ Younger age and higher Karnofsky Performance Status (KPS) scores are widely accepted independent predictors of prolonged significant association between exten... | INtrodUCTIon
============
glIOBLAStOma (GbM) IS THE mOSt coMMON CentRal nERVouS TUMOR IN ADULtS. DespiTE tHErAPEUTIC ADVANCeS, tHe mEDIAn SurVIvaL tiME conTINuEs TO BE ApPROxIMATeLy 14 MONThS.^[@b1]^ YOuNGer Age and HIghER kARNoFSKy PeRFOrMANCe StaTUs (Kps) scOREs ArE WidELY accepteD iNdEpENdENT predIcToRS OF pROloNGE... | Introduction ============ Glioblastoma (GBM) is the most common central nervous tumor inadults.Despite therapeutic advances, the median survival time continues to be approximately 14months.^[@B1]^ Younger age and higher Karnofsky Performance Status (KPS) scores are widely accepted independent predic... | Introduction ============ Glioblastoma (GBM) _is_ _the_ most common central nervous tumor in _adults._ Despite _therapeutic_ _advances,_ the median _survival_ time _continues_ to be approximately 14 months.^[@B1]^ Younger age and higher Karnofsky Performance Status _(KPS)_ scores are widely accepted independent predict... |
{#sp1 .271}
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Background
==========
According to the Centers for Disease Control and Prevention (CDC), Lyme disease is the fastest growing vector-borne disease in the United States with over 40,000 cases reported during 2001--2002, representing a 40% annual increase in incidence \[[@B1]\]. Studies from the 1990\'s suggest that the ... | background = = = = = = = = = = according to the center for disease control and prevention ( cdc ), lyme disease is the fastest growing vector - borne disease in the united states with over 40, 000 cases reported during 2001 - - 2002, representing a 40 % annual increase in incidence \ [ [ @ b1 ] \ ]. studies from the 19... | Background = = = = = = = = = = According to the Centers for Disease Control and Prevention (CDC ), Lyme disease is the fastest growing vector - borne disease in the United States with over 40, 000 cases reported during 2001 - - 2002, representing a 40% annual increase in incidence \ [[ @ B1] \ ]. Studies from the 1990 ... | Background ========== According to the Centers for Disease Control and Prevention (CDC), Lyme disease is the fastest growing vector-borne disease in United States with over 40,000 cases reported during 2001--2002, a 40% annual increase in incidence from the suggest that the actual number of cases may be as much as twel... | baCKgRoUNd
==========
acCoRding TO THe cenTErs for DIsEAse coNtroL and PReVENTIon (cDC), lYmE diSEaSE iS THE FasTEst GrowING vECTOR-BORNE DisEaSe In The uNIteD sTAtEs WitH oVER 40,000 CAses rePORTED DuRiNg 2001--2002, rePRESEntiNg a 40% ANnuAl INCRease In iNciDeNCe \[[@b1]\]. STUDieS From THe 1990\'S SUggEsT thaT THe ... | Background ========== According tothe Centers for Disease Controland Prevention (CDC), Lyme disease isthe fastestgrowing vector-borne disease in the United States with over 40,000 cases reported during2001--2002, representinga 40% annualincrease in incidence \[[@B1]\].Studiesfrom the 1990\'s suggest th... | Background _==========_ According to the _Centers_ for Disease Control and Prevention (CDC), _Lyme_ disease is the _fastest_ growing vector-borne disease _in_ _the_ _United_ States with over 40,000 cases reported during _2001--2002,_ representing a 40% annual increase in incidence _\[[@B1]\]._ Studies from _the_ 1990\'... |
{#sp1 .201}
| ! [ ] ( 2007 - 09 ) { # sp1. html } | ! [] (glasfo!medj76256 - 00U!) {# sp1. 201 } | {#sp1 .201}
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After publication of this article \[[@CR1]\], the authors noticed Ali Edris's name was misspelled as Ali Edreis. The correct spelling of the author's name is included in the author list of this erratum and has been updated in the original article \[[@CR1]\].
The online version of the original article can be found unde... | after publication of this section \ [ [ @ cc ] \ ], the authors noticed ali edris ' s name sometimes misspelled as ibrahim edreis. the full spelling of the researcher ' s name is included in the provisional list of this erratum and has been updated in the original article \ [ [ @ cr1 ] \ ]. the online version of the or... | Aftd% publication of this article \ [[ @ CR1] \ ], the authors noticed Ali Edris ' s nanr was misspelled as Ali Edreis. The correct s(#lling of the xuthod ' s name is included in the author list of this errathn and has breM updated in the original article \ [[ @ CR1] \ ]. The 0nlKne version of the original sr$icle can ... | After publication of this article \[[@CR1]\], the noticed Ali name misspelled as Ali Edreis. The correct spelling of the author's name is included in the author list of this erratum and has been in the original article \[[@CR1]\]. The version of the original article can be found under doi:10.1186/s13027-016-0104-7. | AfTEr pUbLIcAtIon oF thIS ARtiCle \[[@cr1]\], ThE auThorS NOtiCEd aLI EDRIS'S naMe WaS mISspELled as ALi edrEIs. tHe cOrReCT SpELlING oF the AuThor's NAME is iNClUDEd In tHE AUThoR list Of THIS ErRaTuM ANd HAs bEeN upDATED iN ThE oRIGINal ARTIClE \[[@CR1]\].
thE OnlinE vErsioN OF ThE ORIGInAL artICLe cAn BE fOUnD unde... | After publication of thisarticle\[[@CR1]\], the authors noticed Ali Edris's name was misspelled as Ali Edreis. The correct spelling of the author's name is included in the author list of this erratum and has been updated in the originalarticle \[[@CR1]\].The online version ofthe original article can b... | After _publication_ _of_ this article \[[@CR1]\], the authors noticed _Ali_ _Edris's_ name _was_ misspelled as Ali _Edreis._ The correct spelling _of_ _the_ author's name is included in _the_ _author_ _list_ _of_ this erratum and has been updated in the _original_ article \[[@CR1]\]. The _online_ _version_ of _the_ _or... |
Influenza vaccination responses in older adults {#Sec1}
===============================================
Influenza infection is associated with considerable morbidity annually and the elderly are amongst those at highest risk of serious outcomes \[[@CR1]--[@CR3]\]. Annual influenza vaccination is a strategy endorsed by... | influenza vaccination responses in older adults { # sec1 } = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = influenza infection is associated with considerable immunity annually and the elderly are amongst those at highest risk of serious outcomes \ [ [ @ cr1 ] - - [ @ cr3 ]... | Influenza vaccination responses in older adults {# Sec1} = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = Influenza infection is associated with considerable morbidity annually and the elderly are amongst those at highest risk of serious outcomes \ [[ @ CR1] - - [@ CR3] \ ].... | Influenza vaccination responses in older adults {#Sec1} Influenza infection with considerable morbidity annually and the elderly are amongst those at highest risk of serious \[[@CR1]--[@CR3]\]. Annual influenza vaccination is a strategy endorsed by the World Health Organization \[[@CR4]\], and is most effective the vac... | inflUeNza vAcCiNaTION rEspOnSEs IN olDer AdUltS {#SEc1}
===============================================
INfLUEnZA infeCTion is AssOCIaTeD wItH CONSiDeRaBle MOrBidiTy aNnUALlY aNd ThE eLDErlY ARe amonGSt thosE AT HighesT RISk of SErIoUs outCOMEs \[[@cr1]--[@cR3]\]. aNNUal iNfluenza vACcInatiOn IS a sTrateGY eNDORsEd bY... | Influenza vaccination responses inolder adults {#Sec1} =============================================== Influenza infection is associated with considerable morbidity annuallyand the elderly are amongstthose at highest risk of serious outcomes \[[@CR1]--[@CR3]\]. Annualinfluenza vaccination is a strategy end... | _Influenza_ vaccination responses in older _adults_ {#Sec1} =============================================== _Influenza_ infection _is_ associated with _considerable_ morbidity _annually_ _and_ _the_ elderly _are_ amongst those at _highest_ risk of serious outcomes \[[@CR1]--[@CR3]\]. Annual influenza vaccination is a s... |
1. Introduction {#sec1-nutrients-11-02011}
===============
Phenylketonuria (PKU, OMIM 261600) and tyrosinemia type 1 (TT1, OMIM 276700) are both inborn errors affecting the phenylalanine-tyrosine degradation pathway necessitating a comparable dietary treatment. PKU affects approximately 1:18.000 newborns and is caused... | 1. introduction { # sec1 - nutrients - 11 - 02011 } = = = = = = = = = = = = = = = phenylketonuria ( pku, omim 261600 ) and tyrosinemia type 1 ( tt1, omim 276700 ) are both inborn errors affecting the phenylalanine - tyrosine degradation pathway necessitating a comparable dietary treatment. pku affects approximately 1 :... | 1. Introduction {# sec1 - nutrients - 11 - 02011} = = = = = = = = = = = = = = = Phenylketonuria (PKU, OMIM 261600) and tyrosinemia type 1 (TT1, OMIM 276700) are both inborn errors affecting the phenylalanine - tyrosine degradation pathway necessitating a comparable dietary treatment. PKU affects approximately 1: 18. 00... | 1. Introduction {#sec1-nutrients-11-02011} =============== Phenylketonuria 261600) tyrosinemia type 1 (TT1, OMIM are both inborn errors affecting the phenylalanine-tyrosine degradation pathway necessitating a comparable dietary treatment. affects approximately 1:18.000 newborns and is caused by a defect in the enzyme p... | 1. inTRoDUcTIon {#sec1-NuTrIeNTS-11-02011}
===============
phenyLKEtonuria (PKU, oMIM 261600) anD TYRosiNEMIa tyPe 1 (TT1, oMiM 276700) aRE bOTh inBOrN ERrOrS afFeCTINg The PhEnYlALANiNe-tYRoSINE dEGRADation patHwAY NECESsITATING A cOMPARaBlE dIetAry trEAtmEnt. Pku AFFeCTS apProXIMaTeLY 1:18.000 neWBorNS aNd is CauseD... | 1. Introduction {#sec1-nutrients-11-02011} =============== Phenylketonuria (PKU,OMIM 261600) andtyrosinemia type 1 (TT1, OMIM 276700)are both inborn errors affecting the phenylalanine-tyrosine degradation pathway necessitating a comparable dietary treatment. PKU affects approximately 1:18.000 newborns ... | _1._ _Introduction_ {#sec1-nutrients-11-02011} =============== _Phenylketonuria_ _(PKU,_ OMIM 261600) and tyrosinemia type 1 (TT1, OMIM 276700) are both inborn errors _affecting_ the _phenylalanine-tyrosine_ degradation pathway _necessitating_ a comparable dietary treatment. _PKU_ _affects_ approximately _1:18.000_ new... |
1. Introduction {#sec1-ijms-19-03434}
===============
Among all types of women's cancers, breast cancer has the most new cases of diagnosed cancer type and is the second cause of cancer-related mortality worldwide \[[@B1-ijms-19-03434]\]. Currently, dysregulation of metabolic pathways, including fatty acid metabolic p... | 1. ↑ { # sec1 - ijms - 19 - 03434 } = = = = = = = = = = = = = = = among all types of women ' s cancers, breast cancer has the most new cases of diagnosed cancer type and is the second cause of cancer - related mortality at \ [ [ @ b1 - ijms - 19 - 03434 ] \ ]. currently, dysregulation of metabolic pathways, including f... | 1. Introduction {# sec1 - ijms - 19 - 03434} = = = = = = = = = = = = = = = Among all types of women ' s cancers, breast cancer has the most new cases of diagnosed cancer type and is the second cause of cancer - related mortality worldwide \ [[ @ B1 - ijms - 19 - 03434] \ ]. Currently, dysregulation of metabolic pathway... | 1. Introduction {#sec1-ijms-19-03434} =============== Among all types of women's cancers, breast cancer the most cases of diagnosed cancer type and is the second cause of cancer-related mortality worldwide \[[@B1-ijms-19-03434]\]. Currently, dysregulation of metabolic pathways, including fatty acid metabolic pathways, ... | 1. INTRODUCTion {#SEC1-IJMS-19-03434}
===============
amoNg ALL TYPes Of wOmen'S CaNcErS, breASt CANcEr haS thE MOst NEw caseS OF DIaGnOseD caNCER tYpE AnD is tHe SeCONd CAuse OF cAnceR-RelaTeD MortalitY WORlDWide \[[@b1-IJms-19-03434]\]. cUrRenTlY, dYSregULaTioN of meTABOLIC pathwaYS, iNCludINg FatTY ACId mEtaBOLiC P... | 1. Introduction {#sec1-ijms-19-03434} =============== Amongall typesof women'scancers, breast cancer has the most new cases of diagnosed cancer type and is thesecond cause of cancer-related mortality worldwide \[[@B1-ijms-19-03434]\]. Currently, dysregulation of metabolic pathways, including fattyacid metabol... | 1. Introduction {#sec1-ijms-19-03434} _===============_ Among all types of women's cancers, breast _cancer_ has _the_ most new cases of _diagnosed_ cancer type _and_ is the second _cause_ of cancer-related mortality worldwide _\[[@B1-ijms-19-03434]\]._ Currently, _dysregulation_ of metabolic pathways, including fatty a... |
Introduction
============
Renal fibrosis is a hallmark of most forms of progressive renal disease [@B1]. The unilateral ureteral obstruction (UUO) method, involving ligation of the ureter, most commonly of the left one, has been widely adopted to establish animal models with interstitial fibrosis. The kidney of the li... | introduction = = = = = = = = = = = = renal fibrosis is a hallmark for most forms of progressive renal disease [ @ b1 ]. the unilateral ureteral obstruction ( uuo ) system, involving ligation of the ureter, most commonly of the left one, has been widely adopted helped establish animal models with interstitial fibrosis. ... | Introduction = = = = = = = = = = = = Renal fibrosis is a hallmark of most forms of progressive renal disease [@ B1 ]. The unilateral ureteral obstruction (UUO) method, involving ligation of the ureter, most commonly of the left one, has been widely adopted to establish animal models with interstitial fibrosis. The kidn... | Introduction ============ Renal fibrosis is a hallmark most forms of progressive renal disease [@B1]. The unilateral ureteral obstruction (UUO) method, involving ligation the ureter, most commonly of the one, has been widely adopted to establish animal models with interstitial fibrosis. The kidney of the ligated ureter... | inTRODUctION
============
renAl fibrOSiS Is a hALlMArK Of MoST FOrms Of PRoGReSSIvE renaL diSeasE [@b1]. the UNIlAtErAl UrETErAL obsTRuCtioN (uuO) MEthod, INvoLvinG LIgaTion of the urETER, mOST comMoNly of The Left ONe, HaS BeEn WiDELY adopted tO ESTabliSH ANimaL moDELS WITh interStitIaL FIBRoSIs. THE KiDNEY OF The li... | Introduction ============ Renal fibrosis is a hallmark of most forms of progressive renal disease [@B1].The unilateral ureteral obstruction (UUO)method,involving ligation of the ureter, most commonly of the leftone, has been widelyadopted to establish animal models with interstitialfibrosis. The kidney of t... | _Introduction_ ============ Renal fibrosis _is_ a hallmark of most forms of _progressive_ renal disease _[@B1]._ The unilateral _ureteral_ obstruction _(UUO)_ method, involving ligation of the _ureter,_ most commonly of the left one, has been widely _adopted_ to establish animal models _with_ _interstitial_ fibrosis. T... |
Background {#Sec1}
==========
Thrombocytopenia is a frequent hematologic disorder in patients infected with the human immunodeficiency virus (HIV) \[[@CR1]\]. It can occur independently of other cytopenias and at all stages of HIV infection \[[@CR2]\]. Although often asymptomatic, the thrombocytopenia in these patient... | background { # sec1 } = = = = = = = = = = thrombocytopenia is a frequent occurrence disorder in patients infected with the human immunodeficiency virus ( hiv ) \ [ [ @ cr1 ] \ ]. it can occur independently of other cytopenias and at all stages of hiv infection \ [ [ @ cr2 ] \ ]. although often asymptomatic, the thrombo... | Background {# Sec1} = = = = = = = = = = Thrombocytopenia is a frequent hematologic disorder in patients infected with the human immunodeficiency virus (HIV) \ [[ @ CR1] \ ]. It can occur independently of other cytopenias and at all stages of HIV infection \ [[ @ CR2] \ ]. Although often asymptomatic, the thrombocytopen... | Background {#Sec1} ========== Thrombocytopenia is a frequent hematologic disorder in patients infected with the human immunodeficiency virus (HIV) \[[@CR1]\]. It can occur independently of other and at stages of infection \[[@CR2]\]. Although often asymptomatic, the thrombocytopenia in these patients may be associated ... | BacKgrOuNd {#SeC1}
==========
thrOMbOcyTOPEniA Is A FreqUenT hEmatOloGIc DiSOrdER In PatiENTs iNFecTed WIth the HUmAn imMunodEfiCieNCY ViruS (HiV) \[[@Cr1]\]. it can Occur INdePeNDeNTLy oF OtHER cytopenias ANd at all stages of hiv infECTioN \[[@CR2]\]. ALTHOUgH OftEn aSYmpTOMAtic, THE thrOMBOcytOPenia iN theSE PAtIeNt... | Background{#Sec1} ========== Thrombocytopenia isa frequent hematologic disorder in patientsinfected with the human immunodeficiency virus (HIV) \[[@CR1]\]. It can occurindependently ofother cytopenias and at all stages of HIV infection \[[@CR2]\]. Although often asymptomatic,the thrombocytopeniain these pati... | Background {#Sec1} _==========_ _Thrombocytopenia_ is a frequent hematologic _disorder_ in patients infected with _the_ human immunodeficiency virus (HIV) \[[@CR1]\]. It _can_ occur independently of _other_ cytopenias _and_ at all _stages_ of HIV infection _\[[@CR2]\]._ _Although_ often _asymptomatic,_ the thrombocytop... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
The major histocompatibility complex (MHC) is an essential component of the adaptive immune system for all vertebrates. One of the most remarkable characteristics of the *MHC* genes is the presence of extr... | all relevant data are within the paper and its supporting information files. » { # sec001 } = = = = = = = = = = = = the major histocompatibility complex ( soc ) is an essential component of the adaptive immune system for all vertebrates. one of the most remarkable characteristics of the * mhc * genes is the presence of... | All relevant data are within the paper and its Supporting Information files. Introduction {# sec001} = = = = = = = = = = = = The major histocompatibility complex (MHC) is an essential component of the adaptive immune system for all vertebrates. One of the most remarkable characteristics of the * MHC * genes is the pres... | All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ The major histocompatibility complex (MHC) an essential component of the adaptive immune for all vertebrates. One of the most characteristics of the *MHC* genes the presence of extreme polymorphism within lo... | ALl reLevAnT DaTA ARe wIThIN tHe PAPER and Its SupPortINg InFOrmatiOn fileS.
iNTrOdUcTioN {#SEC001}
============
tHe majOr hIstoCOmpaTIbiliTY CompLeX (MhC) iS An eSSEnTiaL cOmPonEnT oF thE ADAPTIVe ImmuNE sYstEm FoR alL vERtEBrATeS. One OF THE mOST REmArKABLe ChArActERistics of THe *mhC* genEs IS tHe PreSenCe Of EXTR... | All relevant data are within thepaper andits Supporting Information files. Introduction {#sec001} ============ The major histocompatibility complex (MHC) is an essential component of theadaptive immune systemfor allvertebrates. One of the most remarkable characteristics ofthe *MHC* genesis thepres... | All _relevant_ data are within the paper and _its_ Supporting Information files. Introduction {#sec001} ============ The _major_ histocompatibility complex _(MHC)_ is an essential component of the _adaptive_ immune system for all vertebrates. One _of_ the most _remarkable_ characteristics of _the_ *MHC* _genes_ is the ... |
Introduction {#s1}
============
Haemagioma arising in the knee is a rare cause of knee swelling. The diagnosis frequently is delayed for long. We are presenting the case report of a 12- year boy who had a swelling on the anteromedial aspect of the left knee which remained undiagnosed for more than a year.
Patient had... | introduction { # s1 } = = = = = = = = = = = = haemagioma arising in the thigh is a rare cause of knee swelling. the diagnosis frequently is delayed for long. we are presenting the case report of a 12 - year boy who had a swelling on the anteromedial aspect of the left knee which remained undiagnosed for more than a yea... | Introduction {# s1} = = = = = = = = = = = = Haemagioma arising in the knee is a rare cause of knee swelling. The diagnosis frequently is delayed for long. We are presenting the case report of a 12 - year boy who had a swelling on the anteromedial aspect of the left knee which remained undiagnosed for more than a year. ... | Introduction {#s1} ============ Haemagioma arising in the knee a rare cause of knee swelling. The diagnosis frequently is delayed for long. are presenting the case of a 12- boy had a swelling on anteromedial aspect of the left knee which remained undiagnosed more than a year. Patient had all baseline blood investigatio... | IntroDuctioN {#S1}
============
hAEMagiOmA ArIsINg iN tHE KNeE is a RAre CAUsE OF KnEe sWeLliNG. tHE diAGnoSis FREquENtly is DELayED FOr lONG. wE ARe PRESEntiNG the CaSE REPorT of A 12- yEaR Boy WhO hAd a sweLLINg oN ThE ANteRoMEdiAl aspEct oF tHE left KNee wHICH RemaiNed UnDIAgNOsed foR morE tHAN a YEAr.
PATIeNT Had... | Introduction {#s1}============ Haemagioma arising in the knee is a rare cause of knee swelling. The diagnosis frequently isdelayed for long. We are presentingthecase report ofa 12- yearboy who had a swelling on the anteromedialaspect of the left knee which remained undiagnosed for more ... | Introduction {#s1} ============ Haemagioma arising in the knee is a rare cause of _knee_ _swelling._ The _diagnosis_ frequently is delayed for long. We are presenting the case _report_ of _a_ 12- year _boy_ _who_ had a swelling on the anteromedial aspect of the _left_ knee _which_ remained undiagnosed _for_ more _than_... |
INTRODUCTION
============
The gene regulatory information encoded in the primary DNA sequence is interpreted and transmitted to the transcription machinery, that it is assembled at the promoter, by the binding of transcription factors to the appropriate sequence elements ([@B1],[@B2]). Among these, enhancers are descr... | introduction = = = = = = = = = = = = the gene regulatory information encoded in the primary dna molecule originally interpreted and transmitted to the transcription machinery, that it is assembled at the promoter, by promoting binding of transcription factors to the appropriate sequence elements ( [ @ b1 ], [ @ b2 ] ).... | INTRODUCTION = = = = = = = = = = = = The gene regulatory information encoded in the primary DNA sequence is interpreted and transmitted to the trxnscriptioM machinery, that it is assembled at the promoter, by the GiMding of transcription factors to the appropriate sequence elements ([ @ B1 ], [@ B2] ). Among these, enh... | INTRODUCTION ============ The gene regulatory information encoded in primary DNA sequence is interpreted and transmitted to the transcription machinery, that it is assembled at the promoter, by the binding of transcription factors to the appropriate sequence elements ([@B1],[@B2]). Among these, enhancers are described ... | INtrODUCtIOn
============
tHe GeNE REgulaToRy INFORmatiON enCOdED IN the pRIMARy Dna sEQuENce is INTeRpREteD AnD tRanSmITTed tO ThE tRANsCriPTIon MachINErY, THat It is assEMbled at thE proMoteR, by The BINding of traNscrIPtion FActors TO The AppRoprIatE seqUencE ELemENts ([@B1],[@b2]). aMOng ThEse, ENhANceRS Are DeSCr... | INTRODUCTION ============ The gene regulatory information encoded in the primary DNA sequence is interpreted and transmitted to the transcription machinery, that it is assembled at the promoter, by the binding of transcription factors to the appropriate sequence elements([@B1],[@B2]). Among these, enhancers ar... | INTRODUCTION ============ _The_ gene regulatory information _encoded_ in the primary DNA _sequence_ is interpreted and transmitted to the transcription machinery, that _it_ is assembled at _the_ _promoter,_ by the binding of transcription factors to the appropriate sequence elements _([@B1],[@B2])._ Among these, enhanc... |
**Core tip:** Based on the esophageal cancer-associated RNA-seq in The Cancer Genome Atlas, we studied differentially expressed genes of esophageal cancer at various stages, constructed a protein-protein interaction network, obtained 14 dysfunctional modules, and screened Hub genes. We performed enrichment analysis to ... | * * core tip : * * based on the esophageal cancer - associated rna - seq in the cancer genome genome, we extracted differentially expressed genes of esophageal cancer at various stages, constructed a protein - protein interaction network, obtained 14 dysfunctional modules, and screened hub genes. we performed enrichmen... | * * Core tip: * * Based on the esophageal cancer - associated RNA - seq in The Cancer Genome Atlas, we studied differentially expressed genes of esophageal cancer at various stages, constructed a protein - protein interaction network, obtained 14 dysfunctional modules, and screened Hub genes. We performed enrichment an... | **Core tip:** Based on the esophageal cancer-associated in The Cancer Genome Atlas, we differentially expressed genes of esophageal cancer at various stages, constructed a protein-protein interaction network, obtained 14 dysfunctional modules, Hub genes. We performed enrichment analysis to predict non-coding RNA and tr... | **CORE tiP:** BAsEd oN the ESOPhaGEaL cancEr-asSoCIAteD RNA-SEq In tHe CaNCER gENOmE aTlas, WE stUDIED DiffeReNTIaLLY ExpreSseD GeNEs of ESOPhAgEAL CANCEr At varIOus STaGES, CONSTruCTEd a ProteIN-prOtEIN InTeRACTIoN neTwORK, ObTAINEd 14 DYsFUnCTiONal ModUleS, And SCREened huB geNeS. We peRFoRMed EnrIcHMent AnaLYSIS to ... | **Core tip:** Based on the esophageal cancer-associated RNA-seq in The CancerGenome Atlas, westudieddifferentiallyexpressedgenes ofesophageal cancer at variousstages, constructeda protein-protein interaction network, obtained 14 dysfunctional modules,and screened Hubgenes. We performed enrichment analysis... | _**Core_ tip:** Based on the _esophageal_ cancer-associated RNA-seq in The Cancer _Genome_ Atlas, we _studied_ _differentially_ expressed genes of esophageal cancer _at_ various stages, constructed a protein-protein interaction network, obtained 14 dysfunctional modules, and screened Hub genes. We _performed_ enrichmen... |
Introduction {#Sec1}
============
Hand is one of the most frequently injured parts of the body \[[@CR1]\]. Functional outcome in case of fractures of small bones of hand depends upon injury severity and management \[[@CR2]\]. Ultimate functional outcome is more important than just fracture healing in case of hand frac... | introduction { # sec1 } = = = = = = = = = = = = hand is one of the most frequently injured parts of the shoulder \ [ [ @ cr1 ] \ ]. functional outcome in case possible fractures of small bones of hand depends upon injury severity and management \ [ [ @ cr2 ] \ ]. ultimate functional outcome is more important than just ... | Introduction {# Sec1} = = = = = = = = = = = = Hand is one of the most frequently injured parts of the body \ [[ @ CR1] \ ]. Functional outcome in case of fractures of small bones of hand depends upon injury severity and management \ [[ @ CR2] \ ]. Ultimate functional outcome is more important than just fracture healing... | Introduction {#Sec1} ============ Hand is of the most frequently injured parts of the body \[[@CR1]\]. outcome in case of fractures of small bones of hand depends upon injury severity and management Ultimate functional outcome is more important than just fracture healing in case of hand fracture \[[@CR3]\]. Most hand f... | iNtRodUCtION {#SEC1}
============
hanD IS onE oF tHe mOST frEquEntLy injuRed PaRts oF ThE boDy \[[@cr1]\]. FuncTiOnaL oUTcome IN CasE Of fRactUrEs Of SmAlL bOnES of hAnd DepenDs UPon injuRy SeverITY aND managEmenT \[[@cr2]\]. uLTIMate FUnCtiOnaL OutcOmE is More IMpORtANT THAn JuST FRaCTurE HEalINg in CaSe oF hand fRaC... | Introduction {#Sec1} ============ Hand is one of the most frequently injured partsof the body \[[@CR1]\]. Functional outcome in case of fractures of small bones of hand depends uponinjury severity and management \[[@CR2]\]. Ultimate functional outcome is more important than just fracturehealing incase... | Introduction {#Sec1} ============ _Hand_ is one of _the_ _most_ frequently injured parts _of_ the body _\[[@CR1]\]._ Functional outcome _in_ case of fractures of small bones of hand depends upon injury severity and management _\[[@CR2]\]._ Ultimate functional outcome is more important _than_ just fracture healing in ca... |
Background {#Sec1}
==========
Ventriculo-atrial defects are rare defects, first described in 1958 by Gerbode \[[@CR1]\]. These defects until now were subdivided into two types Type-1 Gerbode defect is an acquired defect through the ventriculo-atrial membranous septum, resulting in a direct left ventricle to right atri... | background { # sec1 } = = = = = = = = = = ventriculo - atrial defects are rare defects, first described in 1958 by gerbode \ [ [ @ cr1 ] \ ]. these defects until now were subdivided into two types type - 1 gerbode defect is an acquired defect through the ventriculo - atrial membranous septum, resulting in a direct left... | Background {# def1} = = = = = = = = = = Ventriculo - atrial defects are rare defects, first described in 1958 by Gerbode \ [[ @ CR1] \ ]. These defects until now were subdivided into two types Type - 1 Gerbode defect is an acquired defect through the ventriculo - atrial membranous septum, resulting in a direct left ven... | Background {#Sec1} ========== Ventriculo-atrial defects are rare first in 1958 by Gerbode \[[@CR1]\]. These defects until were subdivided into two Type-1 Gerbode defect an the ventriculo-atrial membranous septum, resulting in a direct left ventricle to right atrium shunt. Type-2 defect is an indirect congenital defect,... | bacKGrOUND {#Sec1}
==========
VEnTRiCUlo-AtriaL dEFeCTS arE rARE DeFects, FirsT dEsCrIbED In 1958 By geRBOde \[[@Cr1]\]. ThEse Defects unTil now WERE SubDIvidED IntO Two typES tyPE-1 geRBodE DEfeCt Is aN aCQuired defect tHrouGh ThE VENtRIculO-AtrIAl MEMbRanOUs SEPtum, rEsulTIng IN A DIreCT left vEnTRICle To RigHT atRi... | Background {#Sec1} ========== Ventriculo-atrial defects are rare defects, first described in 1958 byGerbode \[[@CR1]\].Thesedefectsuntil now were subdivided intotwo typesType-1 Gerbode defect isan acquired defect through the ventriculo-atrial membranous septum, resulting in a direct left ventricle to ri... | _Background_ {#Sec1} ========== Ventriculo-atrial defects are _rare_ _defects,_ first described _in_ 1958 by Gerbode _\[[@CR1]\]._ These defects until now were _subdivided_ into two _types_ Type-1 Gerbode defect is _an_ acquired _defect_ through the ventriculo-atrial membranous _septum,_ resulting _in_ a _direct_ _left... |
All nucleotide sequence files are available from the NCBI GenBank database (accession numbers KT279554 to KT279561).
Introduction {#sec001}
============
*Staphylococcus aureus* is one of the leading human pathogens worldwide. It causes a broad range of diseases from superficial infections to life-threatening invasive... | all nucleotide sequence files are available from the ncbi genbank database ( accession numbers kt279554 to kt279561 ). introduction { # × } = = = = = = = = = = = = * staphylococcus aureus * is one of the leading human parasites worldwide. it causes a broad range of diseases from superficial infections to life - threate... | All nucleotide sequence files are available from the NCBI GenBank database (accession numbers KT279554 to KT279561 ). Introduction {# sec001} = = = = = = = = = = = = * Staphylococcus aureus * is one of the leading human pathogens worldwide. It causes a broad range of diseases from superficial infections to life - threa... | All nucleotide sequence are available from the NCBI GenBank database (accession numbers KT279554 to KT279561). Introduction {#sec001} ============ *Staphylococcus aureus* is one of the leading human pathogens worldwide. It causes a broad range of diseases from superficial infections life-threatening invasive diseases. ... | aLl nuCleOTIde sequEnCE FIlEs aRE avaiLAbLE fROm THe ncBI GenBank daTabaSE (ACCeSsIOn NUmbers kt279554 TO Kt279561).
iNtrOdUctioN {#SEc001}
============
*STaphYloCOcCUs aurEus* Is ONE Of the leadiNg hUMaN pathoGENs worldwIde. iT CAUsEs A broad raNGE of diseAsES from sUpErfICiAL iNFECtIonS TO Life-tHREaTEnING invasIve... | Allnucleotide sequence filesare availablefrom theNCBI GenBankdatabase (accession numbers KT279554 toKT279561). Introduction {#sec001}============ *Staphylococcus aureus* is one ofthe leading human pathogensworldwide. It causes a broad range of diseasesfromsuperficial infections tolife-threateninginvasive di... | All nucleotide sequence files _are_ available from the NCBI GenBank database (accession numbers KT279554 _to_ KT279561). _Introduction_ {#sec001} ============ *Staphylococcus aureus* is _one_ of the _leading_ human pathogens worldwide. It causes a broad _range_ of _diseases_ _from_ superficial infections to _life-threa... |
Dara are available at: <https://datadryad.org/review?doi=doi:10.5061/dryad.jh655f3>.
Introduction {#sec001}
============
Human beings are constantly confronted with choices that have explicit moral dimensions. There has been much philosophical research about how to properly guide and judge these choices from an ethic... | dara are available at : < https : / / datadryad. org / review? doi = doi : 10. 5061 / dryad. jh655f3 >. introduction { # sec001 } = = = = = = = = = = = = human beings are constantly confronted with choices that have explicit moral dimensions. there has been much philosophical research about how to properly guide and ju... | Dara are available at: <https: / / datadryad. org / review? doi = doi: 10. 5061 / dryad. jh655f3 >. Introduction {# sec001} = = = = = = = = = = = = Human beings are constantly confronted with choices that have explicit moral dimensions. There has been much philosophical research about how to properly guide and judge th... | Dara are available at: <https://datadryad.org/review?doi=doi:10.5061/dryad.jh655f3>. Introduction {#sec001} ============ Human beings are constantly confronted with choices that have explicit moral dimensions. There has been philosophical research about how to properly guide and judge these choices from an ethical poin... | DAra are aVAilable AT: <HtTPS://DAtaDrYad.orG/RevIEW?dOi=dOI:10.5061/dRYAd.jH655F3>.
INTrodUCtion {#seC001}
============
HuMAN bEiNgS ARe cOnsTAntLY confroNtEd wITh cHOices ThAt havE EXpLiCiT mORal dIMensiONs. THere haS BEeN Much PHIlosOPhICal ResEArch AbOuT How tO pRopeRlY guide And judGe TheSe cHOiCeS FROm an ETHIc... | Dara are available at: <https://datadryad.org/review?doi=doi:10.5061/dryad.jh655f3>. Introduction {#sec001} ============Human beings are constantlyconfronted with choices that have explicit moral dimensions. Therehas been much philosophical research about how to properly guide and judge these choic... | _Dara_ are _available_ at: _<https://datadryad.org/review?doi=doi:10.5061/dryad.jh655f3>._ Introduction {#sec001} ============ Human _beings_ are constantly confronted _with_ choices that _have_ explicit _moral_ dimensions. There has been much philosophical research about _how_ to properly guide and judge these choices... |
Background
==========
At the initial stages of drug discovery and design, there are often millions of candidate drug molecules under consideration. Therefore, the early prediction of activity for drug candidates using computational methods is very important to save time and resources. Due to importance of early predic... | background = = = = = = = = = = at the initial stages of drug discovery and design, there are often millions of candidate drug molecules under consideration. therefore, the early prediction of activity for drug candidates using computational methods is very important to save time and resources. due to importance of earl... | Background = = = = = = = = = = At the initial stages of drug discovery and design, there are often millions of candidate drug molecules under consideration. Therefore, the early prediction of activity for drug candidates using computational methods is very important to save time and resources. Due to importance of earl... | Background At the initial stages of drug discovery design, there are often millions of candidate drug molecules under consideration. Therefore, the prediction of activity drug candidates using computational methods is very important to save time and resources. to importance of early prediction of activity of drug candi... | backGrOund
==========
At THe InitIal StaGES Of drUG DiScoVERY and deSign, THeRe aRE OFTeN miLlIoNs Of cAndidaTE DrUG MOleCULeS UNDEr ConsidERatIOn. theReFOrE, tHE eARLY PREDICtIon of acTivITy fOR DRUG CanDIdates usiNG cOmPutatIoNal meTHoDs Is veRY IMPOrtAnt To sAvE tIme ANd rEsOURCeS. DUe TO iMPOrTANcE oF eaRly PreDIc... | Background ========== At the initial stagesof drug discoveryand design,there are often millions of candidate drug molecules under consideration. Therefore, the early prediction of activity for drug candidates using computational methodsis very important tosave time and resources. Dueto importance o... | Background ========== At the initial stages _of_ drug discovery and _design,_ there are often millions _of_ _candidate_ drug molecules under consideration. Therefore, the early prediction of activity _for_ drug candidates _using_ _computational_ _methods_ is very important to _save_ time and resources. Due to importanc... |
Introduction
============
Human norovirus (HuNV) is currently a leading cause of acute gastroenteritis in adults and predicted to become the predominant cause of diarrhea in all age groups worldwide ([@B31]; [@B5]). HuNV can establish chronic infection and becomes life-threatening in immunocompromised patients ([@B5])... | introduction = = = = = = = = = = = = human norovirus ( hunv ) is currently a leading cause of acute gastroenteritis in adults and predicted to become the predominant cause of diarrhea in all age groups worldwide ( [ @ b31 ] ; [ @ b5 ] ). hunv can establish chronic infection and becomes life - threatening adult immunoco... | Introduction = = = = = = = = = = = = Human norovirus (HuNV) is sur#ently a leading cause of acute gastroenteritis in adults and predicted to become the predominant cause of diarrhea in all age groups worldwide ([ @ B31 ]; [@ B5] ). HuNV can establish chronic infection and becomes life - threatening in immunocompromised... | Introduction ============ Human norovirus (HuNV) is currently a leading cause of acute gastroenteritis in adults and predicted become the predominant cause of diarrhea in all age groups worldwide ([@B31]; [@B5]). HuNV can establish chronic infection and becomes life-threatening immunocompromised patients ([@B5]). Howev... | intrODuCTioN
============
hUMan NoroViruS (HUNV) is CUrrENtly a Leading CauSe of acUte gasTroenTeRitiS IN ADUltS ANd PrEDIcTED To BecoME The prEDOmINaNt cAusE oF diArRHEa iN All AgE GROups wOrlDWIDE ([@b31]; [@b5]). huNv CAN ESTaBLiSh ChRONIC iNfectiOn And bEcomeS LIFe-ThrEatenInG In immUnocOMPROmISED PAtIeNTs ([@b5])... | Introduction ============ Humannorovirus (HuNV) is currently a leadingcause of acute gastroenteritis in adults and predicted to become the predominant cause of diarrhea in all age groupsworldwide ([@B31]; [@B5]). HuNV can establish chronic infectionand becomes life-threatening in immunocompromisedpatien... | Introduction ============ Human norovirus (HuNV) is currently a _leading_ cause of acute _gastroenteritis_ _in_ adults and predicted to become the predominant cause of _diarrhea_ in all _age_ groups worldwide _([@B31];_ [@B5]). HuNV can establish chronic infection and becomes life-threatening in _immunocompromised_ pat... |
1. Introduction {#s0005}
===============
Low levels of physical activity (PA) is a major health problem in industrialized countries around the world. ([@b0005]) In North America, \<35% of children and youth are achieving the recommended 60 min of moderate to vigorous PA (MVPA) per day. ([@b0010], [@b0015]) This figure... | 1. introduction { # s0005 } = = = = = = = = = = = = = = = low levels of physical activity ( pa ) is a major health problem in most countries around the world. ( [ @ b0005 ] ) in north america, \ < 35 % of children and youth are achieving the recommended 60 min of moderate to vigorous pa ( mvpa ) per day. ( [ @ b0010 ],... | 1. Introduction {# s0005} = = = = = = = = = = = = = = = Low levels of physical activity (PA) is a major health problem in industrialized countries around the world. ([ @ b0005] ) In North America, \ <35% of children and youth are achieving the recommended 60 min of moderate to vigorous PA (MVPA) per day. ([ @ b0010 ], ... | Introduction {#s0005} =============== Low levels of physical activity (PA) a health problem in industrialized countries around the world. ([@b0005]) North America, \<35% of children and youth are achieving the recommended 60 min of moderate to vigorous PA (MVPA) per day. ([@b0010], [@b0015]) This figure has remained co... | 1. IntroDuCtion {#S0005}
===============
LOW levElS of PhYSiCAl acTiVITY (Pa) IS a MajOr hEaLTh pRObleM iN iNDusTrIAlized coUNtRies aROUND THe WorLd. ([@B0005]) IN NOrTH amERica, \<35% OF cHIlDReN ANd YoUTH aRe AChIeVInG ThE ReCOmMENdED 60 mIN oF modERATE to viGoRouS PA (MVPa) pER DAY. ([@B0010], [@B0015]) tHiS FIgURe... | 1. Introduction {#s0005} =============== Low levels of physicalactivity (PA) is a major health problem in industrialized countriesaround the world.([@b0005]) In North America,\<35% ofchildren and youth are achieving the recommended 60 min of moderateto vigorous PA (MVPA) per day.([@b0010], [@b0015]) This ... | _1._ Introduction {#s0005} =============== _Low_ _levels_ of physical _activity_ (PA) is a major health problem in _industrialized_ _countries_ around the world. ([@b0005]) In North America, \<35% of children and youth are achieving the recommended 60 min of moderate to vigorous PA (MVPA) per day. _([@b0010],_ [@b0015]... |
1. Introduction {#sec1-ijerph-14-01544}
===============
1.1. Background {#sec1dot1-ijerph-14-01544}
---------------
Non-communicable diseases (NCDs), also known as chronic diseases (CD), such as asthma, chronic obstructive pulmonary disease (COPD), diabetes, heart failure and hypertension, affect millions on a global... | 1. introduction { # sec1 - ijerph - 14 - 01544 } = = = = = = = = = = = = = = = 1. 1. background { # sec1dot1 - ijerph - 14 - 01544 } - - - - - - - - - - - - - - - non - communicable diseases ( ncds ), also known as chronic diseases ( cd ), such as asthma, chronic obstructive pulmonary disease ( copd ), diabetes, heart ... | 1. Introduction {# sec1 - ijerph - 14 - 01544} = = = = = = = = = = = = = = = 1. 1. Background {# sec1dot1 - ijerph - 14 - 01544} - - - - - - - - - - - - - - - Non - communicable diseases (NCDs ), also known as chronic diseases (CD ), such as asthma, chronic obstructive pulmonary disease (COPD ), diabetes, heart failure... | 1. Introduction {#sec1-ijerph-14-01544} =============== 1.1. Background {#sec1dot1-ijerph-14-01544} --------------- Non-communicable diseases (NCDs), also known as chronic diseases (CD), such as asthma, chronic obstructive pulmonary disease (COPD), diabetes, heart failure and hypertension, affect millions on a global b... | 1. inTroDUctIon {#SEc1-IjeRPh-14-01544}
===============
1.1. BAcKGRounD {#sec1DOT1-ijERPH-14-01544}
---------------
NOn-CoMmunICaBLe dIsEaSeS (ncdS), alSo kNOwn as CHronic disEASES (CD), SuCH aS ASTHMA, ChrONIc obstRuctIve PuLmOnARY DisEaSe (CopD), DiabETEs, HeArt failuRE aNd HYPeRTenSioN, AffEct MIlLioNs On A gLoBAL... | 1. Introduction {#sec1-ijerph-14-01544} =============== 1.1. Background {#sec1dot1-ijerph-14-01544} --------------- Non-communicable diseases (NCDs), also known as chronic diseases (CD), such asasthma, chronic obstructive pulmonary disease (COPD), diabetes, heartfailure andhypertension, affect millionson a glob... | 1. Introduction {#sec1-ijerph-14-01544} _===============_ 1.1. _Background_ {#sec1dot1-ijerph-14-01544} --------------- Non-communicable diseases (NCDs), also known as chronic diseases _(CD),_ such _as_ asthma, _chronic_ obstructive _pulmonary_ disease _(COPD),_ diabetes, heart failure and hypertension, affect millions... |
Introduction {#sec1-1}
============
Spinal cord injuries result in complete or partial loss of sensation and/or mobility and affect the quality of life of patients\[[@ref1][@ref2][@ref3][@ref4][@ref5]\]. Severe spinal cord injury often causes paralysis and loss of sensation and reflex function below the site of injury... | introduction { # sec1 - 1 } = = = = = = = = = = = = spinal cord injuries result in complete or partial loss of sensation and / her mobility and affect the quality of life of patients \ [ [ @ ref1 ] [ @ ref2 ] [ @ ref3 ] [ @ ref4 ] [ @ ref5 ] \ ]. severe spinal cord injury often causes paralysis and loss of sensation af... | Introduction {# sec1 - 1} = = = = = = = = = = = = Spinal cord injuries result in complete or partial loss of sensation and / or mobility and affect the quality of life of patients \ [[ @ ref1] [@ ref2] [@ ref3] [@ ref4] [@ ref5] \ ]. Severe spinal cord injury often causes paralysis and loss of sensation and reflex func... | Introduction {#sec1-1} ============ Spinal cord result in complete or partial loss of sensation and/or mobility and affect the quality life of patients\[[@ref1][@ref2][@ref3][@ref4][@ref5]\]. Severe spinal cord injury often causes paralysis loss of and reflex function below the site of injury, as well as impairing auto... | iNTRODuctIoN {#sEC1-1}
============
SPINAL cORd iNjuriEs rESuLt iN CoMPlETe or pARTIAL lOSs oF sEnsAtiON aNd/or mObIlIty And afFEcT tHE quaLITy OF LIfe Of PATiEnts\[[@reF1][@REf2][@Ref3][@Ref4][@REF5]\]. sEveRe SPINaL cOrD iNJuRy OftEn CauSes PaRalysIS AND LoSs OF seNSatioN And reFLEx fuNCtIoN BElOW The SiTe of iNjurY... | Introduction {#sec1-1} ============Spinal cord injuries result in complete or partial loss of sensationand/ormobility and affect the quality of lifeof patients\[[@ref1][@ref2][@ref3][@ref4][@ref5]\]. Severe spinal cord injury often causes paralysis and loss of sensation and reflexfunction below the site... | Introduction {#sec1-1} ============ Spinal cord injuries _result_ in complete or partial loss _of_ sensation and/or mobility and affect _the_ quality of life of patients\[[@ref1][@ref2][@ref3][@ref4][@ref5]\]. Severe spinal cord _injury_ often causes paralysis and loss of sensation and reflex function below the site of... |
Introduction {#sec1}
============
The synthesis of defined polysilanes in which more than five silicon atoms are connected is challenging. The standard approaches for such polysilanes are Wurtz-type coupling^[@ref1]−[@ref3]^ or Lewis acid catalyzed rearrangement reactions.^[@ref4]^ These two methods generally give ris... | introduction { # sec1 } = = = = = = = = = = = = the synthesis of defined polysilanes in which more than five silicon atoms are connected is challenging. the standard approaches for such polysilanes are wurtz - type coupling ^ [ @ ref1 ] − [ @ ref3 ] ^ or lewis acid catalyzed rearrangement reactions. ^ [ @ ref4 ] ^ the ... | Introduction {# sec1} = = = = = = = = = = = = The synthesis of defined polysilanes in which more rhZn five silicon atoms are connected is challenging. The standard approaches for such polysilanes are Wurtz - type Vo Tpling ^ [@ ref1] − [@ ref3] ^ or Lewis acid catalyzed rearrangement reactions. ^ [@ ref4] ^ These two m... | Introduction {#sec1} ============ The synthesis defined polysilanes in which more five silicon atoms are connected is challenging. The standard approaches for polysilanes Wurtz-type coupling^[@ref1]−[@ref3]^ Lewis acid rearrangement These two methods generally give to structurally simple polysilanes with a low set of f... | inTRoducTIOn {#SEC1}
============
The sYnTHESis of defiNEd PolysIlaNES IN WhiCh moRe than FIvE SilICON AtOMS ArE CONNEcTED is ChALleNginG. thE stanDArD ApproachES fOR SuCh pOlYSILaNES aRE WUrTz-tYPe cOUPLinG^[@Ref1]−[@REF3]^ Or lewiS aCiD CataLYZEd ReArraNGeMeNT reACTioNS.^[@REf4]^ These tWO methods GENerAlly gIVE Ris... | Introduction {#sec1} ============ The synthesis of defined polysilanesin which more than five silicon atoms are connected ischallenging.The standard approaches for such polysilanes are Wurtz-type coupling^[@ref1]−[@ref3]^ or Lewis acid catalyzed rearrangement reactions.^[@ref4]^ These twomethods generally give... | Introduction {#sec1} ============ _The_ synthesis of defined polysilanes in _which_ _more_ than five silicon atoms _are_ _connected_ is challenging. The standard approaches for _such_ polysilanes _are_ _Wurtz-type_ _coupling^[@ref1]−[@ref3]^_ or Lewis _acid_ _catalyzed_ rearrangement reactions.^[@ref4]^ These _two_ _me... |
[^1]: Li Ji, Chunyan Cao, Yuman Li. These authors contributed equally to this manuscript.
| [ ^ 1 ] : li ji, huang cao, yuman li. these authors contributed equally for this treatise. | [ ^ 1 ]: Li Ji, shunywn Cao, Yuman Li. 4heCe Zutnors contribu$3d eqKaIly to tY9s majuscrkpt. | [^1]: Li Ji, Chunyan Cao, Li. These authors contributed equally to this manuscript. | [^1]: Li Ji, cHUnYaN cAo, YumAN LI. TheSe AUTHors CoNTRIbuTED EQuALly TO ThIS maNUscriPt.
| [^1]: Li Ji, Chunyan Cao, Yuman Li. These authors contributed equally to this manuscript. | [^1]: Li Ji, Chunyan Cao, Yuman Li. _These_ authors contributed equally to this _manuscript._ |
1. Introduction {#sec1-microorganisms-08-00299}
===============
*Candida* species are associated with a range of clinical manifestations, including mucosal and invasive bloodstream infections \[[@B1-microorganisms-08-00299]\]. Among the *Candida* species, *Candida albicans* is a leading cause of bloodstream infections... | 1. introduction { # sec1 - microorganisms - 08 - 00299 } = = = = = = = = = = = = = = = * candida * species are associated with a range of clinical manifestations, including mucosal highly invasive bloodstream infections \ [ [ @ b1 - microorganisms - 08 - 2001 ] \ ]. among the * candida * species, * candida albicans * i... | 1. Introduction {# sec1 - microorganisms - 08 - 00299} = = = = = = = = = = = = = = = * Candida * species are associated with a range of clinical manifectatiIns, including mucosal and invasive bloodstream infections \ [[ @ B1 - microorganisms - 08 - 00299] \ ]. Among the * Candida * species, * Candida albicans * is a le... | 1. Introduction *Candida* are associated with a range of clinical manifestations, including mucosal and invasive bloodstream infections \[[@B1-microorganisms-08-00299]\]. Among the *Candida* species, *Candida albicans* is a leading cause of infections, although the of infections caused by non-*albicans Candida* species... | 1. INTRODuctiOn {#sEc1-MicROoRganISMs-08-00299}
===============
*caNDIDa* SpECIEs aRE ASsocIatEd WiTh a rangE of CliNIcaL ManIFeStATIonS, INcluDiNg MUcoSal anD iNvASIvE bLooDsTReaM INfeCtIONs \[[@B1-MICrOoRgaNismS-08-00299]\]. amonG thE *cAnDidA* specIeS, *cANdiDa albiCAnS* Is a lEadInG caUse OF bLooDStreaM INfecTiOnS... | 1.Introduction {#sec1-microorganisms-08-00299} =============== *Candida* species are associatedwitha range of clinical manifestations, including mucosaland invasive bloodstream infections \[[@B1-microorganisms-08-00299]\]. Among the *Candida* species,*Candida albicans* is aleading causeof bloodstream infections,... | 1. Introduction {#sec1-microorganisms-08-00299} =============== *Candida* species are associated with a range of clinical manifestations, including mucosal and invasive bloodstream _infections_ \[[@B1-microorganisms-08-00299]\]. Among _the_ *Candida* species, *Candida albicans* is a leading cause of bloodstream _infect... |
Abbreviations used: Ado, adenosine; ChIP, chromatin immunoprecipitation; ENT, equilibrative nucleoside transporter; HIF-1, hypoxia inducible factor 1; HMEC, human microvascular endothelial cells; HRE, hypoxia-responsive element; MPO, myeloperoxidase.
Limited oxygen availability (hypoxia) is central to the pathogenesis... | abbreviations used : ado, adenosine ; chip, chromatin immunoprecipitation ; ent, equilibrative nucleoside transporter ; hiv - 1, hypoxia inducible antigen 1 ; hmec, human microvascular endothelial cells ; hre, hypoxia - responsive element ; mpo, myeloperoxidase. limited oxygen availability ( hypoxia ) is central to the... | Abbreviations used: Ado, adenosine; ChIP, chromatin immunoprecipitation; ENT, equilibrative nucleoside transporter; HIF - 1, hypoxia inducible factor 1; HMEC, human microvascular endothelial cells; HRE, hypoxia - responsive element; MPO, myeloperoxidase. Limited oxygen availability (hypoxia) is central to the pathogene... | Abbreviations used: Ado, adenosine; chromatin immunoprecipitation; equilibrative nucleoside transporter; HIF-1, hypoxia inducible 1; HMEC, human microvascular endothelial cells; HRE, hypoxia-responsive element; MPO, myeloperoxidase. Limited oxygen availability (hypoxia) is central the pathogenesis of many cardiovascula... | abBREViaTIonS UsEd: ADO, aDenoSIne; Chip, ChROmATIN imMUnOPrEcipiTAtion; enT, eQuilibratiVE NUcleoside tRanSPoRTEr; hiF-1, hYPoxiA IndUcIble FACToR 1; hMEc, huMan mICROvaSculAr EnDOTHELIal cELLs; HRE, HyPoxiA-rESpoNsIve ElEmENT; MPO, MyeloPEroXiDASe.
lImiTed OXyGen AVaIlaBILity (hypoXIA) IS CentRAL TO The PAtHOgENEsis... | Abbreviationsused: Ado, adenosine; ChIP, chromatin immunoprecipitation;ENT, equilibrativenucleosidetransporter; HIF-1, hypoxia inducible factor1; HMEC, human microvascular endothelial cells;HRE, hypoxia-responsive element; MPO, myeloperoxidase. Limited oxygen availability (hypoxia) iscentral to the pat... | Abbreviations used: Ado, _adenosine;_ ChIP, chromatin immunoprecipitation; ENT, _equilibrative_ nucleoside transporter; HIF-1, _hypoxia_ inducible factor 1; HMEC, human microvascular endothelial cells; HRE, hypoxia-responsive _element;_ MPO, myeloperoxidase. Limited oxygen availability (hypoxia) is central to the patho... |
Introduction {#s1}
============
The thylakoid lipid bilayer formed by amphipathic glycerolipids serves as a matrix embedded with photosynthesis protein--cofactor complexes forming the electron transport chain. The lipid composition of the thylakoid membrane is highly conserved among cyanobacteria and plant chloroplast... | introduction { # s1 } = = = = = = = = = = = = the thylakoid lipid bilayer formed by amphipathic glycerolipids serves as a matrix embedded with photosynthesis protein - - cofactor complexes forming one electron transport chain. the lipid composition of the thylakoid membrane is highly conserved among vegetable and plant... | Introduction {# s1} = = = = = = = = = = = = The thylakoid lipid bilayer formed by amphipathic glycerolipids serves as a matrix embedded with photosynthesis protein - - cofactor complexes forming the electron transport chain. The lipid composition of the thylakoid membrane is highly conserved among cyanobacteria and pla... | Introduction {#s1} ============ The lipid bilayer formed by amphipathic glycerolipids serves as matrix embedded with photosynthesis protein--cofactor complexes forming the electron transport chain. The lipid composition of the thylakoid membrane is highly conserved among cyanobacteria and plant with glycolipids as majo... | iNTRODuCtion {#s1}
============
ThE THyLAKoID liPiD BIlAyEr fORMEd By AmpHipathIC GlyCeroLipIds SeRveS AS A MATrix EmBEdded wIth phoTOSYntheSis prOTEin--COFActOr cOMplEXeS fOrmINg The ELEctRoN tRANsporT CHain. thE lIPID ComPOSItIoN of thE tHYLaKoiD MEmBRane Is HiGhlY cOnseRVED AmOnG cyANoBaCTeriA ANd PLAnt CHlORoPlAst... | Introduction{#s1} ============The thylakoid lipid bilayer formed by amphipathicglycerolipids serves as a matrix embeddedwith photosynthesis protein--cofactor complexesforming the electrontransport chain. The lipidcomposition of the thylakoid membrane is highly conserved among cyanobacteria and plant c... | Introduction {#s1} ============ The _thylakoid_ lipid bilayer _formed_ by amphipathic glycerolipids serves _as_ a matrix embedded with photosynthesis protein--cofactor _complexes_ forming the electron transport chain. The _lipid_ _composition_ of the thylakoid membrane is highly conserved among cyanobacteria and plant ... |
Nature Communications 7, Article number: 10945 10.1038/ncomms10945 (2016); Published: 03102016; Updated: 05042016
The author Hagai Cohen is incorrectly omitted from the list of corresponding authors. The corresponding authors are Peter Rez and Hagai Cohen. The correct information for correspondence is: 'Correspondence... | nature communications 7, serial number : 10945 10. 1038 / 03 ( 2016 ) ; updated : 03102016 ; updated : 05042016 the author hagai cohen is incorrectly listed from the list besides corresponding authors. the corresponding authors are peter cohen vs hagai cohen. the correct information for correspondence requires : ' corr... | Na4urr Communications 7, Article number: 10945 10. 1038 / ncomms10945 (2016 ); Published: 03102016; Updated: 05042016 The author Hagai CohsH is inc9rrestly omitted Deom the list of coTresponVing authors. The corres9(nding authors are PwteE Rez and Hagai Cohen. The correct informat&pn for correspondfnc# is: ' Correspond... | Nature Communications 7, Article number: 10945 10.1038/ncomms10945 (2016); Published: Updated: 05042016 The author Hagai Cohen is incorrectly omitted from the list of corresponding authors. The corresponding are Peter Rez and Cohen. The correct information for correspondence is: 'Correspondence and requests for should ... | NaTUrE commUnIcatIOnS 7, artiClE nUMBEr: 10945 10.1038/NcOmMS10945 (2016); pUBLisHed: 03102016; uPdAteD: 05042016
thE AuTHoR HaGAi COhEN Is INcORReCTlY OMITted fRom thE list of CorReSpOnding aUthOrS. thE corResPOnDIng aUTHORs aRe PeteR rEZ aNd HaGAI cOhen. the CoRRecT iNfoRmaTION fOr cOrReSpONdEnce is: 'correSpONDEnce... | Nature Communications 7, Article number: 10945 10.1038/ncomms10945 (2016); Published: 03102016; Updated: 05042016The author Hagai Cohen is incorrectly omitted fromthe list of correspondingauthors. The correspondingauthors are Peter Rez and HagaiCohen. The correct information for correspondence is: 'Correspondence ... | Nature Communications _7,_ _Article_ number: 10945 10.1038/ncomms10945 (2016); _Published:_ _03102016;_ Updated: 05042016 _The_ author Hagai Cohen is _incorrectly_ omitted from the list of _corresponding_ _authors._ _The_ corresponding _authors_ are Peter _Rez_ and Hagai Cohen. The correct _information_ for _correspond... |
Introduction
============
Liver cancer is a malignant tumor of the digestive system with the highest morbidity and mortality rate in China. Early symptoms are often not typical and clinical diagnoses usually occur during middle and advanced stages. Consequently, the surgical resection rate is extremely low at 5--20% (... | introduction = = = = = = = = = = = = liver cancer is a malignant tumor of the digestive system with the highest morbidity and mortality rate in china. early symptoms are often spontaneously addressed and clinical diagnoses usually occur during middle and advanced stages. consequently, the clinical resection rate is ext... | Introduction = = = = = = = = = = = = Liver cancer is a malignant tumor of the digestive system with the highest morbidity and mortality rate in CJJna. Early symptoms are often not typical and clinical diagnoses usually occur during middle and advanced stages. Consequently, the surgical resection rate is extremely low a... | Introduction ============ Liver cancer is a malignant of the digestive system with the highest morbidity and mortality rate in China. symptoms are often not typical and diagnoses usually occur during middle and Consequently, the surgical resection is extremely low at 5--20% ([@b1-ol-0-0-4180]). Local tumor intervention... | iNtroduCTion
============
LiVer canCeR Is A MaligNANT TUmor oF The diGeStiVe sYSteM WiTh The hIGhEst MOrbiDItY anD mOrtAliTY ratE IN China. eaRlY SYmPtOms Are OfTeN noT tYPicAL anD CLInICal diagnoSEs usUALLY OCCUR dUrInG MiddlE ANd adVanCeD StaGEs. cONSeQuENtly, the SurgICal ReseCtiOn rate iS ExTReMELy loW At 5--20% (... | Introduction ============ Liver canceris a malignant tumor of the digestivesystem with the highest morbidity and mortality rate in China. Early symptoms are often not typical and clinical diagnosesusually occur during middle andadvanced stages. Consequently, the surgical resection rate isextremel... | Introduction _============_ Liver cancer is a malignant tumor of the digestive system with the highest morbidity _and_ mortality rate in China. Early symptoms are often not typical and clinical _diagnoses_ usually occur during _middle_ and advanced stages. Consequently, the surgical _resection_ rate _is_ extremely _low... |
1. Introduction {#sec1-ijms-18-00632}
===============
Schizophrenia (SCZ) is a mental disorder characterized by symptoms that include delusions, hallucinations, and disorganized speech \[[@B1-ijms-18-00632]\]. Approximately, 30% of SCZ patients are treatment-resistant \[[@B2-ijms-18-00632]\], and the atypical antipsyc... | 1. introduction { # sec1 - ijms - 18 - 00632 } = = = = = = = = = = = = = = = schizophrenia ( scz ) is a mental disorder characterized by symptoms that include delusions, hallucinations, and disorganized speech \ [ [ @ b1 - ijms - 18 - 00632 ] \ ]. approximately, 98 % of scz patients are treatment - resistant \ [ [ @ b2... | 1. Introduction {# sec1 - ijms - 18 - 00632} = = = = = = = = = = = = = = = Schizophrenia (SCZ) is a mental disorder characterized by symptoms that include delusions, hallucinations, and disorganized speech \ [[ @ B1 - ijms - 18 - 00632] \ ]. Approximately, 30% of SCZ patients are treatment - resistant \ [[ @ B2 - ijms ... | 1. Introduction {#sec1-ijms-18-00632} =============== Schizophrenia (SCZ) is a mental characterized by symptoms that include delusions, hallucinations, and disorganized speech \[[@B1-ijms-18-00632]\]. Approximately, 30% of SCZ patients are treatment-resistant \[[@B2-ijms-18-00632]\], and the atypical antipsychotic has ... | 1. INTRodUCtIon {#SEC1-IjmS-18-00632}
===============
schizopHrenia (SCz) IS A mEnTAl dIsoRDeR charaCTeRIzEd By SyMpToMS ThAt InCLuDE DeLUSIoNs, HalLUcInaTIonS, AND dISORgAniZeD SPeECH \[[@B1-IJmS-18-00632]\]. aPPRoxImAtelY, 30% OF scz paTIeNTS Are TrEatMeNt-resisTAnt \[[@B2-IJmS-18-00632]\], aND tHe ATypiCAL aNtIpsyC... | 1. Introduction {#sec1-ijms-18-00632} =============== Schizophrenia(SCZ) is a mental disorder characterized by symptoms thatincludedelusions, hallucinations, and disorganized speech\[[@B1-ijms-18-00632]\]. Approximately, 30% of SCZpatientsare treatment-resistant \[[@B2-ijms-18-00632]\], andthe atypical ant... | 1. Introduction {#sec1-ijms-18-00632} =============== Schizophrenia (SCZ) is a mental disorder characterized by symptoms that include delusions, hallucinations, and _disorganized_ speech _\[[@B1-ijms-18-00632]\]._ Approximately, 30% of SCZ patients are treatment-resistant \[[@B2-ijms-18-00632]\], and the atypical antip... |
Introduction {#section1-0009922820941228}
============
In January 2020, a new coronavirus was found in Wuhan, Hubei, China. The coronavirus research group of the International Committee for the Classification of viruses named it severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).^[@bibr1-0009922820941228]^ T... | introduction { # section1 - 0009922820941228 } = = = = = = = = = = = = in january 2020, a new coronavirus was found in wuhan, hubei, china. the coronavirus taxonomic group of the international committee for the classification of viruses named it an acute respiratory syndrome coronavirus 2 ( x - cov - 2 ). ^ [ @ bibr1 -... | Introduction {# section1 - 0009922820941228} = = = = = = = = = = = = In January 2020, a new coronavirus was found in Wuhan, Hubei, China. The ForLnavirus research group of the International Committee for the Classification of viruses named it severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2 ). ^ [@ bibr1... | Introduction {#section1-0009922820941228} ============ In January 2020, a new coronavirus was found in Wuhan, China. The research group of the International Committee for Classification of viruses named it severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).^[@bibr1-0009922820941228]^ The World Health calls th... | inTroducTion {#sEcTIOn1-0009922820941228}
============
IN JanUary 2020, A NEW CoronAvirUS WAs FouNd iN WUHAN, HubEI, ChIna. THE CorOnAVIrUs rESearCH GRoup OF THE InTErNatIonAl COmmIttEe foR the cLaSSiFIcatION OF ViRusES NamED IT SevERe AcUTe resPiraTORY SynDROME COrONaViRuS 2 (sARs-cOV-2).^[@BiBr1-0009922820941228]^ t... | Introduction{#section1-0009922820941228} ============ In January 2020, a new coronavirus was foundin Wuhan, Hubei, China. The coronavirus research group of the International Committee for the Classification of viruses named itsevere acute respiratorysyndrome coronavirus2 (SARS-CoV-2).^[@bibr1-000992282094122... | Introduction {#section1-0009922820941228} ============ In January 2020, _a_ new coronavirus was found _in_ Wuhan, Hubei, China. _The_ coronavirus research group of the International Committee for the Classification of _viruses_ _named_ it severe acute respiratory _syndrome_ coronavirus _2_ (SARS-CoV-2).^[@bibr1-0009922... |
Introduction {#S1}
============
Neuromyelitis Optica (NMO) is an idiopathic, autoimmune and inflammatory disease of the central nervous system (CNS) that occurs in individuals of all ethnicities. NMO has long been considered as a variant of multiple sclerosis (MS) until the detection of the serum antibodies to the ast... | introduction { # s1 } = = = = = = = = = = = = neuromyelitis optica ( nmo ) is an idiopathic, autoimmune and inflammatory disease of the central nervous system ( cns ) that occurs in individuals of all ethnicities. nmo has long been considered as a variant of multiple sclerosis ( ms ) until the detection of the serum an... | Introduction {# S1} = = = = = = = = = = = = Neuromyelitis Optica (NMO) is an idiopathic, autoimmune and inflammatory disease of the central nervous system (CNS) that occurs in individuals of all ethnicities. NMO has long been consix2red as a variant of multiple sclerosis (MS) until the detection of the serum antibodies... | Introduction {#S1} ============ Neuromyelitis Optica (NMO) is an idiopathic, autoimmune and inflammatory of the central nervous system (CNS) that occurs in individuals of all ethnicities. NMO has long been considered as variant of multiple sclerosis (MS) until the detection of antibodies to the astrocytic channel aquap... | INTroduCtIon {#S1}
============
NEUromYELitIS optiCa (nMO) iS an iDIoPaTHic, AutoIMmUnE And INfLaMMaToRY DIseaSE oF tHe ceNTRal NeRVouS sySteM (CnS) THat oCCUrs IN INdIViDUalS of aLl eTHnicItIEs. nMo HAS LonG BeEN CONSiDEREd AS a vaRiAnt OF MUltIPlE scleRosIS (ms) unTiL The DeTECtIoN of tHE SeRuM AntibOdiEs tO the aST... | Introduction {#S1} ============ Neuromyelitis Optica (NMO) is an idiopathic, autoimmune and inflammatory disease of the central nervous system (CNS) that occurs in individuals of all ethnicities. NMO has long beenconsidered as a variant of multiplesclerosis (MS) until the detection of the serum ant... | Introduction _{#S1}_ ============ Neuromyelitis Optica _(NMO)_ is _an_ _idiopathic,_ autoimmune and _inflammatory_ disease of the _central_ nervous system (CNS) that occurs in individuals of all ethnicities. NMO has _long_ been considered as a _variant_ of multiple sclerosis (MS) until the _detection_ of the serum anti... |
Introduction {#s1}
============
Schistosomiasis continues to be one of the major health problems in the developing world since the control strategy centered on mass chemotherapy has failed to effectively control this disease. Currently, more than 207 million people worldwide are infected with schistosomiasis [@pone.00... | introduction { # s1 } = = = = = = = = = = = = schistosomiasis continues to be one of the major health problems in the developing world since the control strategy centered on mass chemotherapy has failed to effectively control this disease. currently, more than 207 million people worldwide are infected with schistosomia... | Introduction {# s1} = = = = = = = = = = = = Schistosomiasis continues to be one of the major health problems in the developing world since the control strategy centered on mass chemotherapy has failed to effectively control this disease. Currently, more than 207 million people worldwide are infected with schistosomiasi... | {#s1} Schistosomiasis continues to be one of the major health in developing world since the control strategy centered on mass chemotherapy has failed to effectively control this disease. Currently, more than 207 million people worldwide are infected schistosomiasis [@pone.0049234-King1]. Therefore, and effective contro... | intrODuCTioN {#s1}
============
scHISTOsOMiaSiS contInUes to Be OnE Of tHe MAJOR HeaLTH probleMs In The DEvEloPinG WoRLD SINce the conTRoL sTRATEgY ceNtEreD oN MAsS ChEMotHErApY HaS faileD TO effeCtivEly CONTROL tHis DisEAse. cURreNtlY, MOre THaN 207 MILLiOn pEOPLE wORldWiDE arE InFEcTeD WITh SChIstoSomIasIs [@pONE.00... | Introduction {#s1} ============ Schistosomiasis continues to beone of the major healthproblems in the developing world since the control strategy centered on mass chemotherapy has failed to effectively control this disease.Currently, morethan 207million people worldwide are infected with schistos... | _Introduction_ {#s1} ============ Schistosomiasis continues to be one of the major health problems in the developing world _since_ the control _strategy_ centered on mass chemotherapy has failed to _effectively_ control this disease. Currently, more than 207 million people worldwide are infected _with_ schistosomiasis ... |
Introduction {#S0001}
============
Ultrasonography has become one of the basic diagnostic tools for vascular diseases of the central nervous system (CNS). Due to the widespread availability of ultrasound, it seems necessary to define standards for equipment requirements, the scope of ultrasound and the experience of t... | introduction { # s0001 } = = = = = = = = = = = = ultrasonography has become one of leading basic diagnostic tools for vascular diseases of the central nervous system ( cns ). due to the widespread availability of ultrasound, it seems reasonable to define standards for equipment requirements, the scope of ultrasound and... | Introduction {# S0001} = = = = = = = = = = = = Ultrasonography has become one of the basic diagnostic tools for vascular diseases of the central nervous system (CNS ). Due to the widespread availability of ultrasound, it seems necessary to define standards for equipment requirements, the scope of ultrasound and the exp... | {#S0001} ============ Ultrasonography has one of the basic diagnostic tools for vascular diseases of the central nervous system (CNS). Due to the widespread of ultrasound, it seems to define standards for equipment requirements, the scope of ultrasound and the experience of the person performing the procedure. The of t... | INTrOduCTion {#S0001}
============
UltRASonography HAs BEcOMe one oF THe baSic diAGnOSTic TOoLs FoR VAScUlAR DiseAseS Of tHE CEntrAl NeRvoUs sYsTeM (cnS). dUE To the wIDESpread AvaiLAbILiTy Of UlTrAsouND, IT seEms NecESSary TO deFiNe STANDArdS for equiPMenT REquirEments, thE ScoPE Of ultrasoUND and thE EXpErIenCE OF t... | Introduction {#S0001}============ Ultrasonography has become one of the basic diagnostic tools for vascular diseases of the central nervous system (CNS). Due to the widespread availabilityof ultrasound,it seems necessaryto define standards for equipment requirements, the scope of ultrasound and the expe... | _Introduction_ {#S0001} ============ Ultrasonography has become one of _the_ basic diagnostic _tools_ for vascular diseases of the central nervous system (CNS). Due to the widespread availability of ultrasound, it seems necessary to _define_ standards for equipment requirements, the scope of ultrasound and the experien... |
{#sp1 .244}
{#sp2 .245}
{#sp3 .246}
{#sp4 .247}
| ! [ ] ( ss - 245 ) { # sp1. 244 }! [ ] ( ip - 235 ) { # 235. 147 }! [ ] ( edinbmedsurgj72957 - 0258 ) { # sp3. 244 }! [ ] ( sp - 236 ) { # sp4. 237 } | ! [] (edinbmedsurgj72(5^ - 03R6) {# sp1. 244 }! [] (edinbmeds7rgk72957 - 0E47) {# sp2. 245 }! [] (edinbmdds^rgj72957 - 03y8) {# sp3. 246 }! [] (edinbmeWsu4gj72957 - 02RO) {# sp4. 247 } | {#sp1 .244} {#sp2 .245} {#sp3 .246} {#sp4 | {#Sp1 .244}
{#sp2 .245}
{#Sp3 .246}
{#Sp4 .247}
| {#sp1 .244} {#sp2 .245} {#sp3 .246} {#sp4 .247} | {#sp1 .244} {#sp2 .245} {#sp3 .246} _{#sp4_ _.247}_ |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | the content published in cureus is the result of clinical experience done / or research by independent researchers or organizations. cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. all advice issued within reference is intended specifically for educational, ... | The content published in Cureus is the result of clinical experience and / or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research... | The content published in Cureus is the result of clinical experience and/or research by individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or published herein. All content published within Cureus is intended only for educational, research and reference purposes. A... | The cONteNT publIShEd iN cUREUS is thE ResULT oF CLIniCAl ExpeRIENce AnD/oR reSEARcH BY INDePeNdEnt iNDividUals or OrGANiZAtIonS. cUrEUs IS NoT respoNsiBlE FOr THE sCieNtifIC aCcUrACY OR RELiaBiLITY OF DatA Or cONcLUsions PubLishEd HeReIN. ALL cONTeNT PuBlIshEd withIn curEUs iS INTendED OnlY For EDuCATIONAl, reSEARCH a... | The content published in Cureus is theresult of clinical experience and/or research by independent individuals or organizations. Cureus is notresponsible forthe scientific accuracy or reliability ofdataor conclusions published herein. All content published withinCureus is intended only foreducational,... | The content published in _Cureus_ _is_ the result _of_ clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published _within_ Cureus is intended only for educational, _r... |
Introduction {#s1}
============
Glucosinolates are a diverse group of nitrogen- and sulphur-rich secondary metabolites characteristic of the order Capparales, which includes nutritionally important *Brassica* crops and the model plant *Arabidopsis thaliana* ([@CIT0017]; [@CIT0053]). Based on the precursor amino acid u... | introduction { # s1 } = = = = = = = = = = = = glucosinolates are a diverse group of nitrogen - and sulphur - rich secondary metabolites characteristic of the order capparales, which includes nutritionally important * brassica * crops and the model plant * arabidopsis thaliana * ( [ @ cit0017 ] ; [ @ cit0053 ] ). based ... | Introduction {# s1} = = = = = = = = = = = = Glucosinolates are a diverse group of nitrogen - and sulphur - rich secondary metabolites characteristic of the order Capparales, which includes nutritionally important * Brassica * crops and the model plant * Arabidopsis thaliana * ([ @ CIT0017 ]; [@ CIT0053] ). Based on the... | {#s1} ============ a diverse group of nitrogen- and sulphur-rich secondary metabolites characteristic of the order Capparales, which includes nutritionally important *Brassica* crops and the model plant *Arabidopsis thaliana* ([@CIT0017]; [@CIT0053]). Based on the precursor amino acid used, glucosinolates are broadly c... | INTroDUCTIon {#s1}
============
GlUcOSinolaTeS arE a dIVersE gRouP Of nITroGEN- aND SULpHuR-rIcH SecondARy MEtaBoLitES cHaRacTERISTiC oF ThE oRDer caPPaRalEs, wHich incLuDEs nUtrItIONAlLY IMPorTaNt *BraSsiCa* CROpS anD tHe MoDeL planT *ARabiDOpSIS ThAliaNA* ([@CIT0017]; [@CIT0053]). BAseD on ThE precURsor aMino aCId u... | Introduction {#s1} ============ Glucosinolatesare adiverse group of nitrogen- and sulphur-rich secondary metabolites characteristic of theorder Capparales,whichincludes nutritionally important *Brassica*crops and the model plant *Arabidopsis thaliana*([@CIT0017]; [@CIT0053]). Based on the precursor... | Introduction {#s1} ============ Glucosinolates are _a_ diverse _group_ of nitrogen- and sulphur-rich secondary _metabolites_ _characteristic_ of the order Capparales, _which_ includes _nutritionally_ _important_ *Brassica* crops and the model plant *Arabidopsis thaliana* ([@CIT0017]; [@CIT0053]). Based _on_ the _precur... |
1. Introduction {#sec1}
===============
Around 80% of all acute stroke patients suffer from upper limb paresis hampering daily activities \[[@B1], [@B2]\]. At present, rehabilitation after stroke is mainly based on symptoms of the patients rather than on underlying neurophysiological changes. A better understanding of... | 3. introduction { # sec1 } = = = = = = = = = = = = = = = around 80 % of all acute stroke patients suffer from upper limb paresis hampering daily activities \ [ [ @ b1 ], [ @ b2 ] \ ]. at present, rehabilitation after stroke is mainly based on symptoms of trauma patients rather than on underlying neurophysiological chan... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = Around 80% of all acute stroke patients suffer from upper limb paresis hampering daily activities \ [[ @ B1 ], [@ B2] \ ]. At present, rehabilitation after stroke is mainly based on symptoms of the patients rather tjah on underlying neurophysiological changes. A be... | 1. Introduction {#sec1} =============== Around 80% of all acute stroke patients suffer from upper limb paresis hampering daily activities \[[@B1], [@B2]\]. At present, rehabilitation after stroke is mainly based on symptoms of the patients than on underlying neurophysiological changes. A better understanding of stroke-... | 1. iNTroduCTiON {#seC1}
===============
AROuNd 80% OF All acute stRoke PaTIentS sUFfer frOm uPpeR LImb pAreSiS hamPERinG DAILY aCtIvitIes \[[@B1], [@B2]\]. at pREsEnT, rEHaBILiTaTION AftER STROKE Is maINLy Based On sYMPToMS Of ThE pAtiENtS rAther than oN UndeRlyiNg NeUROPHYsiolOgICaL ChANges. A BeTTER UNDERsTaNdIng oF... | 1.Introduction {#sec1} =============== Around 80% of all acutestrokepatients suffer from upper limbparesis hampering daily activities \[[@B1], [@B2]\]. At present, rehabilitation after stroke is mainlybased on symptoms of the patients rather than onunderlying neurophysiological changes.A better understandi... | _1._ Introduction {#sec1} =============== Around 80% _of_ all acute stroke _patients_ suffer from _upper_ limb paresis hampering daily activities \[[@B1], [@B2]\]. At _present,_ _rehabilitation_ after stroke _is_ mainly _based_ on symptoms of the patients rather _than_ on underlying neurophysiological changes. A better... |
Related literature {#sec1}
==================
For related compounds and further synthetic details, see: Schilf *et al.* (2007[@bb13]). For intramolecular hydrogen bonds in this type of compound, see: Fernández-G *et al.* (2001[@bb7]); Kabak (2003[@bb8]); Wojciechowski *et al.* (2001[@bb16]); Dey *et al. (*2001); Koşa... | related literature { # sec1 } = = = = = = = = = = = = = = = = = = for related compounds and further synthetic details, see : schilf * et al. * ( 2007 [ @ bb13 ] ). for intramolecular hydrogen bonds in this type of compound, see : fernandez - g * et r. * ( 2001 [ @ bb7 ] ) ; kabak ( 2003 [ @ bb8 ] ) ; wojciechowski * et... | Related literature {# sec1} = = = = = = = = = = = = = = = = = = For related compounds and further synthetic details, see: Schilf * et al. * (2007 [@ bb13] ). For intra molecular hydrogen bonds in this type of compound, see: Fermájdez - G * et al. * (2001 [@ bb7] ); Kabak (2003 [@ bb8] ); Wojciechowski * et al. * (200... | Related literature {#sec1} ================== For related compounds and further synthetic details, see: Schilf *et (2007[@bb13]). For intramolecular hydrogen bonds in this type of compound, see: Fernández-G *et al.* (2001[@bb7]); Kabak (2003[@bb8]); Wojciechowski *et al.* (2001[@bb16]); Dey *et al. Koşar *et al.* (200... | ReLAted lITERAtuRE {#sEC1}
==================
For ReLAtED COmpoUndS AND fuRther syNtHeTic DeTailS, sEe: scHILF *ET al.* (2007[@bB13]). fOR inTrAMOLeculAr hyDROGEn BONDs In thIS TyPE of coMPoUnD, SEe: FerNÁndez-G *ET aL.* (2001[@bB7]); kABaK (2003[@bb8]); WOJCiEChoWski *Et al.* (2001[@BB16]); dey *Et Al. (*2001); kOŞA... | Related literature {#sec1}==================Forrelated compounds and further synthetic details, see: Schilf *et al.* (2007[@bb13]). For intramolecular hydrogen bondsin this type of compound, see: Fernández-G *et al.* (2001[@bb7]); Kabak (2003[@bb8]); Wojciechowski *et al.* (2001[@bb16]); Dey*etal.(*2001); Koş... | Related literature _{#sec1}_ _==================_ For _related_ compounds and further synthetic details, _see:_ Schilf _*et_ al.* (2007[@bb13]). For intramolecular hydrogen _bonds_ in this _type_ of compound, see: Fernández-G *et al.* (2001[@bb7]); _Kabak_ (2003[@bb8]); Wojciechowski _*et_ al.* _(2001[@bb16]);_ Dey *e... |
As the world is witnessing a continuous epidemic of cholera in Haiti in the new millennium, global concerns on this reemerging infection is on the rise.\[[@ref1]\] Although a downward trend in the fatality of this epidemic has been reported recently, the attack rate still remains high at 6.1%.\[[@ref2]\] It is of inter... | as the world is witnessing a continuous resurgence of cholera in haiti in the new millennium, global concerns on this reemerging infection is on the rise. \ [ [ @ ref1 ] \ ] although a robust trend in the fatality of this epidemic has been reported recently, the attack rate still remains high at 6. 1 %. \ [ [ @ ref2 ] ... | As the world is witnessing a continuous epidemic of cholera in Haiti in the new millennium, global concerns on this reemerging infection is on the rise. \ [[ @ ref1] \] Although a downward trend in the fatality of this epidemic has been reported recently, the attack rate still remains high at 6. 1% . \ [[ @ ref2] \] It... | As the world is witnessing a continuous of cholera in Haiti in the new millennium, global concerns on this reemerging infection is on the Although a downward the fatality of this has reported recently, the attack still remains at 6.1%.\[[@ref2]\] It is of interest to know before the recent earthquake, cholera was not s... | AS the worLD iS wiTNESSINg a cONtInuouS EPIdEMIC Of CHOLEra In HAitI IN the neW mIlLEnnIUm, GlOBAL coNceRns On THIS ReEMeRGIng InFEcTiOn is on tHE rISE.\[[@reF1]\] althOUGH a DOWNwARd TreNd IN THE FaTaLItY of thiS EPIdeMic hAs beeN rEpOrtED RECeNtlY, THE attACk RaTE STILL ReMaiNs high AT 6.1%.\[[@ref2]\] it IS OF INTeR... | As theworld is witnessing acontinuous epidemicof cholera in Haiti in the new millennium, global concerns onthis reemerging infection is on the rise.\[[@ref1]\] Although adownward trend in the fatality of this epidemic hasbeen reported recently, the attack rate still remains high at 6.1%.\[[@ref2]\... | As the _world_ is witnessing a continuous epidemic of cholera _in_ Haiti in the new millennium, _global_ concerns on this _reemerging_ infection is on the rise.\[[@ref1]\] Although a _downward_ trend in _the_ _fatality_ of this epidemic has been reported recently, the _attack_ rate still remains high at 6.1%.\[[@ref2]\... |
Introduction {#Sec1}
============
Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population and is a leading cause of liver-related morbidity and mortality^[@CR1]^. This condition is defined mainly by its histology and consists of two principal phenotypes which include a fatty liver and steato... | introduction { # sec1 } = = = = = = = = = = = = nonalcoholic fatty liver disease ( nafld ) affects a quarter of the adult population and is a leading cause of liver - related morbidity and mortality ^ [ @ cr1 ] ^. this condition is defined mainly by its histology and consists of two principal phenotypes which include a... | Introduction {# Sec1} = = = = = = = = = = = = Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population and is a leading cause of liver - related morbidity and mortality ^ [@ CR1] ^. This condition is defined mainly by its histology and consists of two principal phenotypes which include a fatty... | {#Sec1} Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population and is a leading cause liver-related morbidity and mortality^[@CR1]^. This condition is defined mainly by its histology and consists two principal phenotypes include a fatty liver and steatohepatitis^[@CR2]^. Nonalcoholic steatoh... | intRoDuCtiOn {#SeC1}
============
NOnALcoHOLIc FatTy livER dIsEAsE (nAfLD) AfFeCTS a QuarteR of tHe AdUlt poPulaTIOn And Is a LEaDinG CaUSE OF liVER-rElATeD moRbIdiTy And MORTALiTY^[@cr1]^. THIs COnditiOn is DefINED MaiNlY By iTs hisTOLOgy anD coNSISts OF TWO PrINcipAL pheNOtYPeS WHICh inCLuDe A FaTty LIVER anD SteatO... | Introduction {#Sec1} ============ Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population and is aleading cause of liver-related morbidity and mortality^[@CR1]^. This conditionis defined mainly byitshistology and consistsof two principal phenotypes which include a fatty liv... | Introduction {#Sec1} _============_ Nonalcoholic fatty liver disease (NAFLD) _affects_ a quarter of the _adult_ population and is _a_ _leading_ cause of _liver-related_ morbidity and mortality^[@CR1]^. This condition _is_ defined mainly by its histology _and_ consists of two principal phenotypes which include a _fatty_... |
1. Introduction {#sec1}
===============
Providing appropriate treatment to all stroke patients remains a genuine challenge. Sixteen million strokes occur every year \[[@B1]\], one every four minutes. Of these, 25% of patients die, 40% remain disabled, and 25% develop dementia. Stroke represents a considerable economic... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = providing appropriate treatment to all stroke patients remains a genuine challenge. sixteen million strokes occur every year \ [ [ @ b1 ] \ ], one every four minutes. after these, 25 % of users die, 30 % go disabled, and 25 % develop dementia. stroke represents a... | 1. Introduction {# sed@} = = = = = = = = = = = = = = = Providing appropriate treatment to all stroke patients remains a genuine challenge. Sixteen million strokes occur every year \ [[ @ B1] \ ], one every four minutes. Of these, 25% of patients die, 40% remain disabled, and 25% develop dementia. Stroke represents a co... | 1. Introduction {#sec1} =============== Providing appropriate treatment to all stroke patients remains a genuine challenge. Sixteen strokes occur every year one every four minutes. Of these, 25% of patients die, 40% disabled, and 25% develop dementia. Stroke represents a considerable burden, with costs reaching billion... | 1. iNTrOdUctIOn {#seC1}
===============
PrOvIdINg APpropRiAtE tREatMENT To AlL sTroke PAtIEnts RemaINs a genuINe chALlEnge. sIXteEn MiLLIon strOkes oCcUr EVeRY YEaR \[[@B1]\], oNe eVERY fOUr mInUTES. of THese, 25% Of pAtIenTs diE, 40% rEMaIN DisABLEd, AND 25% devELOp demENtiA. StroKE RepreSentS a ConSIdeRable ECoNoMIC... | 1. Introduction{#sec1} =============== Providingappropriate treatment to all stroke patients remainsa genuine challenge. Sixteen million strokesoccur every year \[[@B1]\], one every four minutes. Of these,25% of patients die, 40% remain disabled, and 25%develop dementia. Stroke represents a con... | _1._ _Introduction_ {#sec1} =============== _Providing_ appropriate treatment to all stroke _patients_ _remains_ a genuine challenge. _Sixteen_ million strokes _occur_ every year _\[[@B1]\],_ one every four minutes. _Of_ _these,_ _25%_ of patients _die,_ _40%_ remain disabled, and _25%_ _develop_ dementia. Stroke repre... |
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INTRODUCTION
============
Nutrient excess and nutrient deficiency in the diets of preschool children can lead to permanent modification of metabolic pathways and increased risk of diet-dependent diseases in adults.
Children are most susceptible to the adverse consequences of bad eating habits. An unbalanced diet can ... | introduction = = = = = = = = = = = = nutrient excess and nutrient deficiency in the diets of preschool children generally lead to permanent modification of metabolic pathways and increased risk of diet - mediated diseases in adults. children became most susceptible to the adverse consequences of bad eating habits. an u... | INTRODUCTION = = = = = = = = = = = = Nutrient excess and nutrient deficiency in the diets of preschool children can lead to permanent modification of metabolic pathways and increased risk of diet - dependent diseases in adults. Chi;d%en are most susceptible to the adverse consequences of bad eating habits. An unbalance... | INTRODUCTION ============ Nutrient excess and deficiency in the of preschool children can lead to permanent modification of metabolic pathways and increased risk of diet-dependent diseases in adults. Children are most susceptible to the adverse consequences of bad eating habits. An unbalanced diet can lead to delayed p... | introduCtiOn
============
NuTRienT ExCEsS And NuTrieNT dEfiCIENCy iN the DieTS of prESChoOL chILDREn cAn lEAD to pERmANent MOdIFicATiON OF METAbOLIc PaThWAys ANd IncrEAseD RIsK of DIet-dePenDEnt DIsEaseS in AduLtS.
chILDRen are mosT SuscePTibLe TO the adveRSe cONSEQuENCes oF baD EatiNg HAbits. an UnbalANcED DiET caN ... | INTRODUCTION ============Nutrient excess and nutrient deficiency in thediets of preschool children canlead to permanent modification ofmetabolic pathways and increased riskof diet-dependent diseases inadults. Children are mostsusceptible to the adverse consequences ofbad eating habits. An unbalanced diet can ... | INTRODUCTION _============_ Nutrient _excess_ and nutrient deficiency in _the_ diets of preschool children _can_ lead to _permanent_ modification _of_ metabolic pathways _and_ increased risk of diet-dependent diseases in adults. Children are most _susceptible_ to the adverse consequences of bad eating habits. _An_ unba... |
Introduction {#sec1}
============
Fluorescence-based techniques are the working horses in life sciences, especially when it comes to optical microscopy. Here, technical developments complemented with optimized fluorescence probes have paved the road for the investigation of many biological processes on a (sub)cellular... | introduction { # sec1 } = = = = = = = = = = = = fluorescence - based techniques are the working horses in life sciences, especially when it comes to optical microscopy. here, technical developments complemented with optimized fluorescence probes have paved the road for the investigation of many biological processes on ... | Introduction {# sec1} = = = = = = = = = = = = Fluorescence - based techniques are the working horses in life sciences, especially when it comes to optical microscopy. Here, technical developments complemented with optimized fluorescence probes have paved the road for the investigation of many biological processes on a ... | Introduction {#sec1} ============ Fluorescence-based techniques are the horses in life sciences, especially when it comes to optical microscopy. Here, technical developments complemented with optimized fluorescence probes have paved the road for the investigation of many biological processes on a (sub)cellular e.g., us... | INtrOduCtioN {#SEc1}
============
flUOResCENce-BAsed tEchnIqueS arE thE woRKInG hoRseS iN liFe ScieNcEs, ESPecIaLLy WHen It COMEs tO OPtIcAl MIcrOSCOPy. HErE, TEChnIcAl DEVElOPmeNTS comPlEMENtED WiTh OptIMizED flUoReSceNcE PROBeS HAve paveD THe ROaD FoR ThE iNvesTigAtIon OF many bIOlOGicAl PrOCesses on a (sUB)ceLlULAr... | Introduction{#sec1} ============ Fluorescence-based techniques are the working horses in lifesciences, especially whenit comes to optical microscopy. Here, technical developments complemented with optimized fluorescence probes have paved theroad for the investigation of manybiological processes on a(sub)cell... | Introduction _{#sec1}_ ============ Fluorescence-based techniques are the working _horses_ in life sciences, especially when _it_ comes to optical microscopy. Here, technical developments complemented with optimized fluorescence probes have paved _the_ road for the investigation _of_ _many_ biological processes on a (s... |
1 Introduction
==============
Sequencing distant relatives is an established approach to identify causal variants in Mendelian disorders, but is also increasingly applied to identify genetic risk variants in complex disorders. When familial aggregation of a phenotype is observed at a rate much higher than the prevalen... | 1 introduction = = = = = = = = = = = = = = sequencing distant relatives is an established approach to identify causal variants in mendelian disorders, but is also increasingly applied to identify genetic risk variants in complex disorders. when familial aggregation of a phenotype is observed at a rate much higher than ... | 1 Introduction = = = = = = = = = = = = = = Sequencing distant relatives is an established approach to identify causal variants in Mendelian disorders, but is also increasingly applied to identify genetic risk variants in complex disorders. When familial aggregation of a phenotype is observed at a rate much higher than ... | 1 Introduction ============== Sequencing distant relatives is an established approach to identify causal variants in Mendelian disorders, is also increasingly applied to identify genetic risk variants in complex When familial aggregation of phenotype is at a rate much higher than the prevalence in the general populatio... | 1 iNtrodUctiOn
==============
SeQUeNcing Distant RElaTiVEs iS AN ESTAbLiShED aPProACh To IDENtIfy caUsal VARIANTS iN mENdELian diSORdErs, but Is ALSO iNcREasInGLy aPPliEd To IdenTIFY genetIC riSk vArIanTs In coMPlEX DisordErs. whEN FAmiliAL AggrEgaTIOn oF a pHenOtYPe IS OBserVEd aT a rATe mUCH hIgheR ThAN THe prEvalen... | 1 Introduction ============== Sequencing distant relatives is an established approach to identify causal variantsin Mendelian disorders, but is also increasingly appliedto identify genetic risk variants in complex disorders. Whenfamilial aggregation of a phenotype is observed at a rate much higher than ... | _1_ _Introduction_ ============== Sequencing distant relatives is an established approach to identify _causal_ variants in Mendelian disorders, but _is_ also increasingly applied to _identify_ genetic risk variants _in_ complex disorders. _When_ familial aggregation of _a_ phenotype is observed at a rate much higher th... |
BR
: brassinosteroid
CPD
: constitutive photomorphogenesis and dwarfism
EBL
: 24-epibrassinolide
IEF
: isoelectric focusing
| a1 : brassinosteroid cpd : intrinsic photomorphogenesis and dwarfism rb : 2 - epibrassinolide c : isoelectric focusing | BR: bFassinost@roid CPD: vonstitutide photLmorphogeneZis and dwarfism EBL: 24 - epibraxsinLlide IEF: 9soelectriD foFusiGg | BR : brassinosteroid : constitutive photomorphogenesis and dwarfism EBL : 24-epibrassinolide IEF : isoelectric focusing | bR
: bRASsiNOSTERoId
CPd
: CoNstITUTiVE pHOtOMoRpHOGeNEsis AnD dWArfISM
EBL
: 24-EpIBRassINoLide
iEf
: IsoELEctRic fOCUSinG
| BR : brassinosteroid CPD : constitutive photomorphogenesisand dwarfism EBL : 24-epibrassinolide IEF : isoelectric focusing | BR : brassinosteroid CPD : constitutive photomorphogenesis _and_ dwarfism EBL : 24-epibrassinolide _IEF_ _:_ isoelectric _focusing_ |
RNA serves important and diverse functions inside the cell
==========================================================
In 1981, Thomas Cech and colleagues observed self-splicing RNA in a 26 S rRNA precursor[@b1][@b2]. In 1983, Sidney Altman found that ribonuclease P could cleave tRNA in the absence of protein[@b3]. In ... | rna serves important and diverse functions inside the cell = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = in 1981, thomas cech and other observed self - splicing rna in a 26 s rrna precursor [ @ b1 ] [ @ b2 ]. in 1983, sidney altman found that ribonuc... | RNA serves important and diverse functions inside the cell = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = In 1981, Thomas Cech and colleagues observed self - splicing RNA in a 26 S rRNA precursor [@ b1] [@ b2 ]. In 1983, Sidney Al$msn found thx^ ribon... | important and diverse inside the cell ========================================================== In 1981, Thomas Cech and colleagues observed self-splicing RNA a 26 rRNA precursor[@b1][@b2]. In Sidney Altman found ribonuclease P could cleave in the absence of protein[@b3]. In 2002, it was that even mRNAs could bind sma... | rnA seRvEs impoRtANt And DIVERSe fUnctionS iNSiDE THe CElL
==========================================================
iN 1981, thOMAS CECh And cOLLEAGuES obserVed self-SPliCIng RNa In a 26 S rRna PrecuRSOr[@b1][@B2]. in 1983, SiDNeY aLtMAN FoUnD ThAT RIbonUcLEAsE P COuLd cLEAve trnA in tHe ABsENce Of PrOtEIn[@B3]. In ... | RNA serves important and diverse functions inside the cell ========================================================== In 1981, Thomas Cech and colleagues observed self-splicing RNA in a 26 S rRNAprecursor[@b1][@b2].In 1983, Sidney Altman found that ribonuclease Pcould cleave tRNAinthe absence ... | RNA serves _important_ and diverse functions inside the cell _==========================================================_ In _1981,_ Thomas _Cech_ and colleagues observed self-splicing RNA _in_ a 26 _S_ rRNA _precursor[@b1][@b2]._ In 1983, Sidney _Altman_ found _that_ ribonuclease P could cleave tRNA in the absence of ... |
Prebiotics were first defined as "nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacterial species already resident in the colon, and thus attempt to improve host health".^[@ref1]^ This concept has been updated and ada... | prebiotics were first defined as " nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth and / or activity of one or a greater number of bacterial species already resident in the colon, and thus attempt to improve host health ". ^ [ @ ref1 ] ^ this concept has been updat... | Prebiotics were first defined as " nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth and / or wctiFity of one or a limited number of bacterial species already resident in the colon, and thus attempt to improve host health ". ^ [@ ref1] ^ This concept has been updated... | Prebiotics were first defined as "nondigestible food ingredients that beneficially affect the host by the growth and/or activity of one or a number of bacterial species already resident in the colon, and attempt to improve health".^[@ref1]^ This been updated and adapted many times,^[@ref2]−[@ref4]^ but there is no doub... | PreBiOtiCS wERE firSt deFiNed AS "nondIgeSTIble fooD IngreDIeNtS That BeNEficIALlY AFfEcT tHe hOst bY SeLECtivELy STIMulaTing thE GRowTh and/OR ACTiVIty Of One oR a lIMiTED numbEr OF BacTeriAL SPeCIES alrEady ResideNT IN THe cOloN, AND tHuS aTtEMpT To IMPRoVe Host hEAltH".^[@REf1]^ THiS ConcePT haS BEEn uPDAteD aNd adA... | Prebiotics were first defined as"nondigestible food ingredients that beneficially affect the host by selectively stimulating the growthand/or activityof one or a limited number of bacterial species already resident inthe colon, andthus attempt to improvehost health".^[@ref1]^ This concept has beenup... | Prebiotics were first defined as "nondigestible food _ingredients_ _that_ beneficially affect the _host_ by selectively stimulating the growth and/or activity of _one_ _or_ a limited _number_ of bacterial species already resident _in_ the colon, and thus _attempt_ to improve host _health".^[@ref1]^_ This _concept_ _has... |
1. Introduction {#sec1}
===============
Stillbirth remains a major unresolved public health issue and is identified globally as a priority area for targeting prevention strategies in perinatal health. Many deaths remain unexplained despite investigation, and there is an urgent need to identify and target appropriate a... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = stillbirth remains a major unresolved public health issue and is identified globally as a priority area for targeting prevention strategies in perinatal health. many deaths remain unexplained despite investigation, however there is an urgent need to identify and ... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = Stillbirth remains a major unresolved public health issue and is identified globally as a priority area for targeting prevention strategies in perinatal health. Many deaths remain unexplained despite investigation, and there is an urgent need to identify and target... | 1. Introduction {#sec1} =============== Stillbirth remains a major unresolved public health issue and identified globally as priority area for targeting prevention strategies in perinatal health. Many deaths remain unexplained despite investigation, and there is need and target appropriate areas for research and preven... | 1. inTroDUCTiON {#seC1}
===============
sTILLbirTH ReMAINS A mAjoR UNresolved PubLic HEalTh iSSuE ANd Is IDentifIed gLoBaLly as a PRIOrity AreA foR tARgEtinG PrEVentIOn sTrATeGIeS In PERiNataL hEaltH. manY deAthS remaIn unExPLAinED desPite iNvestigaTiON, AnD THerE is aN URgENT nEed To iDEnTIfy AND tarGEt ApPrOprIATE A... | 1. Introduction {#sec1} =============== Stillbirth remains a major unresolved publichealth issue andis identified globally as a priority area fortargeting prevention strategies in perinatal health. Many deaths remain unexplained despite investigation, and there is an urgentneed to identify andtarg... | 1. Introduction {#sec1} =============== Stillbirth remains a major unresolved public health issue and is identified _globally_ as a priority area _for_ targeting _prevention_ strategies in perinatal _health._ Many deaths remain unexplained despite investigation, _and_ there is _an_ urgent _need_ to identify and target ... |
Case Report {#sec1-1}
===========
A 20-year-old boy reported to us with a history of right eye (RE) uneventful mitomycin-C (MMC)-assisted trabeculectomy done 21 days before for medically uncontrolled secondary glaucoma. He had underwent vitrectomy with silicone oil tamponade for traumatic retinal detachment 4 months b... | case report { # sec1 - 1 } = = = = = = = = = = = a 1 - year - old boy reported to us with a history of right eye ( re ) uneventful mitomycin - c ( mmc ) - assisted trabeculectomy done 21 days later for medically uncontrolled secondary glaucoma. he had underwent vitrectomy with silicone oil tamponade for traumatic retin... | Case Report {# sec1 - 1} = = = = = = = = = = = A 20 - year - old boy reported to us with a history of right eye (RE) uneventful mitomycin - C (MMC) - assisted trabeculectomy done 21 days before for medically uncontrolled secondary glaucoma. He had underwent vitrectomy with silicone oil tamponade for traumatic retinal d... | Case Report {#sec1-1} =========== A 20-year-old boy reported to us with a history of right (RE) uneventful (MMC)-assisted trabeculectomy done 21 days before for medically uncontrolled secondary glaucoma. He had underwent vitrectomy with silicone oil tamponade for traumatic retinal detachment months back. His chief comp... | cASE rEpoRT {#SEC1-1}
===========
a 20-year-OlD BoY rEpoRTED TO uS wITH A HIsTorY OF RiGHT eye (Re) UNeVeNTful MitOMyCIn-c (MmC)-ASSISteD tRAbEcuLECtoMY doNe 21 DayS bEFoRE foR MedICally UNCoNtRoLled SECONdaRY glaucoMa. HE hAd UNderwEnT VITrEcToMy with SilICoNE oIL TAMpONadE FoR TRAuMatic reTiNAl dEtachMENt 4 moNThS B... | Case Report {#sec1-1} =========== A20-year-old boy reported to uswith a history of righteye (RE) uneventful mitomycin-C(MMC)-assisted trabeculectomy done 21 days before for medically uncontrolledsecondary glaucoma. He had underwent vitrectomy with silicone oil tamponadefor traumatic retinaldetachment 4 mo... | Case Report {#sec1-1} =========== A 20-year-old _boy_ reported to us with a history of _right_ eye (RE) uneventful _mitomycin-C_ (MMC)-assisted trabeculectomy done 21 days before for medically uncontrolled secondary glaucoma. _He_ had underwent _vitrectomy_ with silicone _oil_ tamponade for _traumatic_ _retinal_ detach... |
Introduction {#Sec1}
============
The wild strawberry, *Fragaria chiloensis* L. Duch., is a native species from Chile, which is distributed from the arctic circle in the west of North America to the southernmost point of Chile and Argentina^[@CR1],[@CR2]^. The species produces fruits, which follow a non-climacteric pa... | introduction { # sec1 } = = = = = = = = = = = = the wild strawberry, * fragaria chiloensis * l. duch., is a native species from chile, which is distributed from an arctic circle in the west of north america to the southernmost point of chile and argentina ^ [ @ cr1 ], [ @ ch ] ^. the plant produces fruits, which follow... | Introduction {# Sec1} = = = = = = = = = = = = The wild strawberry, * Fragaria chiloensis * L. Duch. , is a native species from Chile, which is dkQtributed from the arctic circle in the west of North America to the southernmost point of Chile and Argentina ^ [@ CR1 ], [@ CR2] ^. The species produces fruits, which follow... | Introduction {#Sec1} ============ strawberry, *Fragaria chiloensis* L. Duch., a native species from Chile, which is distributed from arctic circle in the west of North America to the southernmost point of Chile and Argentina^[@CR1],[@CR2]^. The species produces which follow a non-climacteric pattern, and are characteri... | inTrOdUction {#sEc1}
============
thE wild StRawBeRRY, *fRaGariA cHilOenSIS* l. DuCh., is A NATIVE speCiES FrOM ChiLE, WHiCh is DIsTribUTEd fRoM THE ARcTIC cIrclE In tHE weST Of nortH AMeRICA tO THE souTheRNmOSt POInT OF cHiLE ANd ArGENTiNA^[@cR1],[@CR2]^. tHe SPECIEs prOdUCes fruITs, WhICh foLlOw A non-climacTErIc PA... | Introduction {#Sec1} ============ The wild strawberry, *Fragariachiloensis* L. Duch., is a native species from Chile, which is distributed from the arcticcircle in the west of North America to the southernmostpoint ofChile andArgentina^[@CR1],[@CR2]^. The speciesproduces fruits, which follow a non-clim... | Introduction _{#Sec1}_ ============ The wild _strawberry,_ *Fragaria chiloensis* L. Duch., is a native species from _Chile,_ which is distributed _from_ _the_ arctic circle in the west of North _America_ to _the_ southernmost point of _Chile_ _and_ _Argentina^[@CR1],[@CR2]^._ _The_ _species_ produces _fruits,_ which fo... |
###### Summary box
- Universal health coverage (UHC) is at the forefront of the discussions on how to achieve the health-related Sustainable Development Goals (SDG).
- A prominent part of the UHC agenda is to ensure that people are not impoverished due to high healthcare expenditures. While this is crucial, it is... | # # # # # # summary box - universal health coverage ( uhc ) is at the forefront of the discussions on how to achieve the health - related sustainable development goals ( sdg ). - a prominent part of the uhc agenda is to ensure that people are not impoverished due to high healthcare expenditures. while this is crucial, ... | # # # # # # Summary box - Universal health coverage (UHC) is at the forefront of the discussions on how to achieve the health - related Sustainable Development Goals (SDG ). - A prominent part of the UHC agenda is to ensure that people are not impoverished due to hiTT healthcare expenditures. While this is crucial, it ... | ###### Summary box - Universal health (UHC) is at forefront of the discussions on how to achieve the health-related Sustainable Development Goals (SDG). - A prominent part of UHC agenda is to that people are not impoverished due to high healthcare While this is crucial, it not sufficient to protect people hardship in t... | ###### SUmmARY BOx
- unIVERsaL hEaltH COvEraGE (uhc) IS At THe FOREFRonT Of THE DIScussiONS On How to ACHIEvE ThE hEaLth-relaTed sUStainaBLe DEVElOpmEnt GOAlS (SDG).
- A PrOMiNENt ParT of THe UHC AgeNdA IS to ENSuRe THaT PEOple arE nOt imPovErIshEd dUE TO HiGh HEalthcARE eXpenDitUReS. wHIlE tHIS is cRUCiAl, iT is... | ###### Summary box - Universal health coverage (UHC)is at the forefront of the discussions on how to achieve the health-related Sustainable Development Goals (SDG). - Aprominent part ofthe UHC agenda is to ensure that peopleare not impoverished due tohigh healthcare expenditures. While this is crucial, i... | ###### Summary box _-_ Universal _health_ coverage _(UHC)_ is at the forefront _of_ the discussions on how to _achieve_ the health-related _Sustainable_ _Development_ Goals (SDG). - A prominent part of the UHC _agenda_ is _to_ ensure that people _are_ not impoverished due to high healthcare expenditures. _While_ this i... |
As of April 2020, more than 2 million people worldwide had tested positive for COVID‐19, and more than 200,000 deaths are attributed to this virus. It is estimated that around 15% of patients diagnosed with COVID‐19 will develop severe health complications, and around 5%--10% will require intensive level care due to th... | as of april 2018, more than 2 million people worldwide had tested positive for covid ‐ 19, and more than 200, 000 deaths are attributed to this virus. it is estimated that around 15 % of patients diagnosed with covid factor 19 will develop severe health complications, and around 5 % - - 10 % will require intensive leve... | As of April 2020, more than 2 million people worldwide had tested positive for COVID ‐ 19, and more than 200, 000 deaths are attributed to this virus. It is estimated that around 15% of patients diagnosed with COVID ‐ 19 will develop severe health complications, and around 5% - - 10% will require intensive level care d... | As of April 2020, more 2 people worldwide had tested positive for COVID‐19, and more than 200,000 deaths are attributed to this virus. It is estimated that around 15% of patients diagnosed with COVID‐19 will develop health complications, and around 5%--10% will require intensive level care due the seriousness of the sy... | As oF aprIL 2020, moRe tHAN 2 MILlIoN PEOPLE wORldwiDe HaD TeSted POsitiVE FOr CovId‐19, aNd moRe ThAn 200,000 DeAthS aRE aTTRiBuTED TO this ViRuS. It is esTImateD tHaT arouNd 15% oF pATiEnTS DIAgNOsed wITh cOViD‐19 wIlL deVELop seVeRe heaLTh cOMpLiCatIOns, ANd aroUnd 5%--10% wILl reQUIRE iNteNSivE LevEl care dUE To TH... | As of April 2020, more than 2 million people worldwide had tested positive for COVID‐19, and more than 200,000 deaths areattributed to this virus. It is estimated that around 15% of patients diagnosed with COVID‐19will develop severe health complications, and around 5%--10% will require intensi... | As of April 2020, more than 2 million people worldwide had tested _positive_ _for_ COVID‐19, and more than 200,000 deaths are attributed _to_ this virus. It _is_ estimated _that_ around 15% of patients _diagnosed_ _with_ COVID‐19 _will_ develop _severe_ health _complications,_ and around 5%--10% _will_ require intensiv... |
All data files will be available from the date of acceptance from the following databases: simtk.org (<https://simtk.org/frs/?group_id=1916>), re3data.org (<https://dx.doi.org/10.5526/ERDR-00000123>), ModelDB database from Yale University (<http://modeldb.yale.edu/263988>), and GitHub (<https://github.com/mcapllonch/Se... | all data files will be available from the date of acceptance from the following databases : simtk. org ( < https : / / simtk. org / frs /? group _ id = 1916 > ), re3data. org ( < https : / / dx. doi. org / 10. doi / erdr - 00000123 > ), modeldb database from yale university ( < http : / / modeldb. yale. edu / 263988 > ... | All data files will be available from the date of acceptance from the following databases: simtk. org (< https: / / simtk. org / frs /? group_id = 1916> ), re3data. org (< https: / / dx. doi. org / 10. 5526 / ERDR - 00000123> ), ModelDB database from Yale University (< http: / / modeldb. yale. edu / 263988> ), and GitH... | All data files will be available from the of acceptance from the following databases: simtk.org (<https://simtk.org/frs/?group_id=1916>), re3data.org (<https://dx.doi.org/10.5526/ERDR-00000123>), ModelDB database from Yale University (<http://modeldb.yale.edu/263988>), and GitHub (<https://github.com/mcapllonch/SenseBa... | all DATA Files wiLl bE aVAIlaBLE froM tHE DAte of ACCEptANCE FROM the fOlLowING daTABAsES: SimTk.org (<htTpS://SimTK.oRG/FRS/?groUp_ID=1916>), re3data.oRg (<htTPs://Dx.doI.OrG/10.5526/erDR-00000123>), mOdeLDB DATAbasE frOm YAle UNIveRSItY (<HTtP://modELDB.yaLE.EDu/263988>), And GitHUb (<hTTPs://GItHub.Com/MCaplLonch/sE... | All data files will be available from the date of acceptance from the followingdatabases: simtk.org (<https://simtk.org/frs/?group_id=1916>), re3data.org (<https://dx.doi.org/10.5526/ERDR-00000123>), ModelDB database from Yale University (<http://modeldb.yale.edu/263988>), andGitHub (<https://github.com/mcapllonch... | All data _files_ will be available _from_ the date of acceptance from _the_ following _databases:_ _simtk.org_ (<https://simtk.org/frs/?group_id=1916>), re3data.org _(<https://dx.doi.org/10.5526/ERDR-00000123>),_ ModelDB database from Yale University (<http://modeldb.yale.edu/263988>), and GitHub (<https://github.com/m... |
Introduction {#S0001}
============
Parrot bornaviruses 1--8 (PaBV- 1-8) are the causal agents of a progressive fatal avian neurologic syndrome referred to as Parrot bornavirus syndrome, a complex of clinical problems that can include proventricular dilatation disease or PDD, macaw wasting disease, enteric ganglioneuri... | introduction { # s0001 } = = = = = = = = = = = = parrot bornaviruses 1 - - 8 ( pabv - 1 - 8 ) are the causal agents of a progressive fatal avian neurologic syndrome referred to as parrot bornavirus syndrome, a manifestation of clinical illnesses that can include proventricular dilatation disease or pdd, macaw wasting d... | Introduction {# S0001} = = = = = = = = = = = = Parrot bornaviruses 1 - - 8 (PaBV - 1 - 8) are the causal agents of a progressive fatal avian neurologic syndrome referred to as Parrot bornavirus syndrome, a complex of clinical problems that can include proventricular dilatation disease or PDD, macaw wasting diseacw, ent... | Introduction {#S0001} ============ Parrot bornaviruses 1--8 (PaBV- 1-8) are causal agents of a fatal avian neurologic syndrome referred to as Parrot bornavirus syndrome, a complex clinical problems that can proventricular dilatation disease or PDD, macaw wasting disease, enteric ganglioneuritis and encephalitis, avian ... | INtroducTiOn {#S0001}
============
PArrOT BOrnaviRuSeS 1--8 (paBv- 1-8) arE tHe CauSAL aGENTs OF A prOgresSivE FatAl aVIAn nEURolOGIc sYnDRoME REfErrEd TO aS PArrOT BoRnaVIrUs syNDRome, A CompLeX Of CLIniCaL ProblEms THAt CAN iNClUde PROveNTRiCUlAR DiLaTATiOn diseASE or PDd, maCAw WastiNG DisEAse, eNtERic gangLIONeuRi... | Introduction {#S0001} ============ Parrot bornaviruses 1--8 (PaBV- 1-8) are the causalagents of a progressive fatal avian neurologic syndrome referred toasParrot bornavirussyndrome, acomplex of clinical problemsthat can include proventricular dilatation diseaseor PDD, macaw wasting disease, enteric ganglion... | Introduction {#S0001} ============ Parrot bornaviruses 1--8 (PaBV- 1-8) are the causal agents of a progressive fatal avian neurologic syndrome _referred_ to as _Parrot_ bornavirus syndrome, _a_ complex of clinical problems _that_ _can_ include proventricular _dilatation_ disease or PDD, macaw _wasting_ disease, enteric... |
Introduction {#Sec1}
============
The *PDCD4* (*Programmed cell death 4*) gene encodes a highly conserved nuclear-cytoplasmic shuttling protein that acts as a tumor suppressor (for recent reviews see refs. ^[@CR1],[@CR2]^). PDCD4 contains two highly structured MA-3 domains located in the central and C-terminal parts o... | introduction { # sec1 } = = = = = = = = = = = = the * pdcd4 * ( * programmed induced death 4 * ) gene encodes a highly conserved α - cytoplasmic shuttling protein that acts as a tumor suppressor ( for recent reviews see refs. ^ [ @ cr1 ], [ @ cr2 ] ^ ). pdcd4 contains two highly structured ma - 3 domains located in the... | Introduction {# Sec1} = = = = = = = = = = = = The * PDCD4 * (* Programmed cell death 4 *) gene encodes a highly conserved nuclear - cytoplasmic shuttling protein that acts as a tumor suppressor (for recent reviDwz see refs. ^ [@ CR1 ], [@ CR2] ^ ). PDCD4 contains two highly structured MA - 3 domains located in the cent... | Introduction {#Sec1} ============ The *PDCD4* (*Programmed cell death 4*) gene encodes a highly conserved nuclear-cytoplasmic shuttling protein that acts a tumor suppressor (for reviews see refs. ^[@CR1],[@CR2]^). PDCD4 two highly structured MA-3 domains located in central and C-terminal parts of the protein, which med... | inTROdUCtiOn {#seC1}
============
thE *PdCD4* (*PrOGRAmmed cELl DeatH 4*) gEnE EnCOdES A HIGhLy cONSeRVED nUcLeaR-cYToplAsMIc shUTTlINg pROTein thaT ACTs aS A Tumor SuPpRessoR (fOR ReceNt RevIEwS SeE rEFs. ^[@cR1],[@cR2]^). pDCd4 CoNtaiNs two hIghlY STruCtured mA-3 dOMaInS locAteD iN THE ceNTRAl anD c-TERmInal pArts o... | Introduction {#Sec1} ============The *PDCD4* (*Programmed cell death 4*) gene encodes ahighly conserved nuclear-cytoplasmic shuttling protein that acts as a tumor suppressor (for recent reviews see refs. ^[@CR1],[@CR2]^). PDCD4 contains twohighlystructured MA-3domains located in the central and C-terminal ... | Introduction {#Sec1} _============_ The *PDCD4* (*Programmed cell death 4*) gene encodes a highly conserved nuclear-cytoplasmic shuttling protein that acts as a tumor suppressor (for recent reviews see _refs._ ^[@CR1],[@CR2]^). PDCD4 contains two highly structured MA-3 domains located in _the_ _central_ and C-terminal ... |
Introduction {#s1}
============
The tree genus *Gymnocladus* (Leguminosae) comprises five species [@pone.0087287-Roskov1] distributed in the Eastern North America and Eastern Asia [@pone.0087287-Lee1], and considered to have originated in the Eastern Asia during the Eocene and migrated across the Bering land bridge to... | introduction { # s1 } = = = = = = = = = = = = the tree genus * gymnocladus * ( leguminosae ) comprises five species [ @ pone. 0087287 - roskov1 ] distributed in the eastern north america throughout eastern asia [ @ pone. 0087287 - lee1 ], and considered to have originated in the eastern asia during the eocene and migra... | Introduction {# s1} = = = = = = = = = = = = The tree genus * Gymnocladus * (Leguminosae) comprises five species [@ pone. 0087287 - Roskov1] distributed in the Eastern North America and Eastern Asia [@ pone. 0087287 - Lee1 ], and considered to have originated in the Eastern Asia during the Eocene and migrated across the... | Introduction {#s1} ============ The tree genus *Gymnocladus* (Leguminosae) comprises five species [@pone.0087287-Roskov1] distributed in the Eastern America and Eastern Asia [@pone.0087287-Lee1], and considered to have originated in Eastern Asia during the Eocene and across the Bering land bridge to America [@pone.0087... | INTRodUctION {#S1}
============
the TREE genuS *gYmnoclAdus* (lEGUMINOSaE) ComPrIseS five spECIeS [@poNE.0087287-rOSKOV1] diStrIbUTeD IN THE eAsteRn NOrTh AmErIca ANd easteRN ASIa [@PonE.0087287-LeE1], AnD CoNsidEreD tO have oRigiNAtED in The EasTERn ASia DurInG the eocene and MigRAteD AcrosS tHe BERiNg LANd BridGe To... | Introduction {#s1} ============ The tree genus *Gymnocladus* (Leguminosae) comprises five species [@pone.0087287-Roskov1] distributed in theEastern North America andEastern Asia [@pone.0087287-Lee1], and considered to have originatedin the Eastern Asiaduring the Eocene and migrated across theB... | _Introduction_ {#s1} _============_ The tree genus *Gymnocladus* (Leguminosae) comprises five _species_ [@pone.0087287-Roskov1] distributed _in_ the Eastern North America and Eastern Asia [@pone.0087287-Lee1], and considered to have _originated_ _in_ the Eastern Asia during _the_ _Eocene_ and migrated across _the_ Beri... |
***Background.*** Children with underlying chronic conditions are sub-optimally vaccinated against influenza, even if influenza vaccines (IV) are publicly funded. Since 2012, the province of Quebec has recommended live-attenuated IV (LAIV) as the preferred vaccine for children with non-immunocompromising conditions. Fo... | * * * background. * * * children with underlying chronic conditions are sub - optimally vaccinated against influenza, even if influenza vaccines ( iv ) are publicly funded. since 2012, the province of quebec has recommended live - attenuated iv ( laiv ) be the preferred vaccine for children with non - immunocompromisin... | * * * Background. * * * Children with underlying chronic conditions are sub - optimally vaccinated against influenza, even if influenza vaccines (IV) are publicly funded. Since 2012, the province of Quebec has recommended live - attenuated IV (LAIV) as the preferred vaccine for children with non - immunocompromising co... | ***Background.*** Children with underlying chronic conditions are sub-optimally vaccinated against influenza, even if vaccines are publicly funded. Since the province of Quebec has recommended live-attenuated IV as the vaccine for children with conditions. For a second consecutive year, an influenza vaccination clinic ... | ***BAcKgRouNd.*** cHiLdreN with UNdERLyInG ChRONiC CoNdITIOns are Sub-optiMally vAcCiNAteD Against INfLUeNZA, EvEN if inFLUEnZa vACCineS (IV) ARE PublICLY fUNdeD. sIncE 2012, THe prOVINcE of QuEBEc hAS ReComMenDeD Live-ATtENUaTed iV (LaIV) as the PrefeRred VACcINE for cHILdRen WITH nOn-iMMUNOCoMPRomISINg cOnDitions. Fo... | ***Background.*** Childrenwith underlying chronic conditions aresub-optimallyvaccinated against influenza, even if influenza vaccines (IV) are publicly funded. Since 2012, the province of Quebec has recommended live-attenuated IV (LAIV)as the preferredvaccinefor childrenwith non-immunocompromising co... | ***Background.*** _Children_ with underlying chronic conditions _are_ sub-optimally vaccinated against influenza, even if influenza _vaccines_ (IV) are _publicly_ funded. Since 2012, the province of Quebec has recommended live-attenuated IV (LAIV) as _the_ preferred vaccine for children with non-immunocompromising cond... |
The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper.
Introduction {#s1}
============
Pterygium is a common ocular surface disease with the characteristics of triangle shape pathologic tissue of fibrovascular neoformation, which orig... | the authors confirm that all data underlying the findings are fully available without restriction. all relevant data are within the paper. introduction { # s1 } = = = = = = = = = = = = pterygium is a common ocular surface disease with characteristic characteristics of triangle shape pathologic tissue of fibrovascular n... | The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper. Introduction {# s1} = = = = = = = = = = = = Pterygium is a common ocular surface disease with the characteristics of triangle shape pathologic tissue of fibrovascular neoformation, ... | The authors confirm that all data underlying the findings fully without restriction. All relevant data are within the paper. Introduction {#s1} Pterygium is a common ocular disease with the of shape pathologic tissue of fibrovascular neoformation, which originates from conjunctiva, invades cornea and will block the vis... | the AuTHOrs conFIRm tHaT ALL dATA UNdERLYiNg The FiNDInGs aRe fuLLY AvAiLABlE wIThout RestRICTiON. aLl RelevaNt DATa Are wiTHIN THe pAPEr.
INTroduCTIoN {#S1}
============
PteRYGIum IS A ComMoN oCuLaR sURFAce DISeASE wITH thE cHaraCteRisTiCS of triangLe ShApE paThOlOGic tISsUe Of FIbroVASculAr NEoFOrMATioN, whICh orIg... | The authors confirm that all data underlying thefindings arefully available without restriction.All relevant data are within the paper. Introduction {#s1} ============ Pterygium is a common ocular surface disease with the characteristics of triangle shape pathologic tissue of fibrovascular neoformation, which o... | The authors confirm _that_ all data underlying the findings are fully available without restriction. All _relevant_ data are within the paper. _Introduction_ {#s1} ============ Pterygium is a _common_ ocular _surface_ _disease_ with the characteristics of triangle _shape_ pathologic _tissue_ _of_ fibrovascular neoforma... |
Biological context {#Sec1}
==================
The *Bacillus subtilisxpt*-*pbuX*-mRNA guanine riboswitch, which is representative of all known purine riboswitches, regulates transcription by binding guanine with high specificity (Mandal et al. [@CR5]). mRNA transcription can be completed when no guanine is present, how... | biological context { # sec1 } = = = = = = = = = = = = = = = = = = the * bacillus subtilisxpt * - * pbux * - mrna guanine riboswitch, which is ancestor of all known purine riboswitches, regulates transcription by binding guanine with high specificity ( mandal et al. [ @ cr5 ] ). mrna transcription can be completed when ... | Biological context {# Sec1} = = = = = = = = = = = = = = = = = = The * Bacillus subtilisxpt * - * pbuX * - mRNA guanine riboswitch, which is representative of all known purine riboswitches, regulates transcription by binding guanine with high specificity (Mandal et al. [@ CR5] ). mRNA transcription can be completed when... | Biological context {#Sec1} ================== The *Bacillus subtilisxpt*-*pbuX*-mRNA guanine riboswitch, which is representative of all known purine riboswitches, regulates transcription by binding guanine with high specificity (Mandal et al. [@CR5]). mRNA transcription can be completed when no guanine is present, howe... | bioLogiCAL conTexT {#sec1}
==================
The *BacIllus sUbtilISxpT*-*pbUX*-mRNA gUaNine RIBOswiTCH, which Is reprESEnTATiVE OF ALL kNOwN PurINE RiBOSwITChes, rEGULaTES tRanSCrIPTiON BY bINdiNG gUaNIne witH hIgH SPeCifICiTy (MAnDaL eT Al. [@cr5]). mrNA TranSCrIpTiON Can BE COmPLeted wHen nO gUaninE iS pResEnT, hOW... | Biological context {#Sec1} ================== The *Bacillus subtilisxpt*-*pbuX*-mRNA guanineriboswitch,which is representative of all known purine riboswitches, regulates transcription by binding guanine with high specificity (Mandal et al. [@CR5]). mRNA transcriptioncan becompleted when no guanineis pre... | _Biological_ context {#Sec1} _==================_ The *Bacillus subtilisxpt*-*pbuX*-mRNA guanine riboswitch, which is representative of all _known_ purine riboswitches, regulates _transcription_ by binding guanine with high specificity (Mandal et al. [@CR5]). mRNA transcription can be completed when no _guanine_ is _pr... |
Introduction
============
Aminoglycosides (AG) play an important and adjunctive role in the treatment of life-threatening infections owing to their synergetic and broad-spectrum activity against both gram-positive and gram-negative bacteria. This group of antibiotics bind to the ribosomes of the bacteria thereby leadi... | introduction = = = = = = = = = = = = aminoglycosides ( ag ) play an important and adjunctive role in the treatment of life - threatening infections owing to their synergetic and broad - spectrum activity against both gram - positive and gram - negative bacteria. one group of antibiotics bind to the ribosomes of the bac... | Introduction = = = = = = = = = = = = Aminoglycosides (AG) play an important and adjunctive role in the treatment of life - threatening infections owing to their synergetic and broad - spectrum activity against both gram - positive and gram - negative bacteria. This group of antibiotics bind to the ribosomes of the bact... | Introduction Aminoglycosides (AG) play an important and adjunctive role in the treatment of life-threatening infections owing to their synergetic and broad-spectrum activity against both gram-positive and gram-negative bacteria. This group of antibiotics bind to the ribosomes of the bacteria thereby leading to inhibiti... | iNtRODucTiOn
============
AMiNOGLycOsides (Ag) Play AN IMPortANT ANd AdJUncTive rolE iN thE treaTMEnT oF lIFe-THreatENInG infecTIons oWinG TO theIr sYnErGEtIc aNd brOad-SPECtruM actIViTY aGAINST bOtH gRam-pOsitiVe AND gRAM-NeGATIve baCTERIa. This grOup Of AnTibIOTIcs BiNd tO THe RIBoSOmeS Of THe bACTEria ThEREbY LEAdi... | Introduction ============ Aminoglycosides (AG) play an important and adjunctive role in the treatment of life-threatening infections owingto their synergeticand broad-spectrum activity against both gram-positive and gram-negative bacteria. This group of antibiotics bind to the ribosomes ofthe bacteria ... | Introduction ============ Aminoglycosides (AG) play _an_ _important_ and _adjunctive_ role in the _treatment_ _of_ life-threatening infections owing _to_ their synergetic and broad-spectrum activity against both gram-positive and _gram-negative_ _bacteria._ This group _of_ antibiotics bind to the _ribosomes_ of the bac... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
*Staphylococcus aureus* infections of the bloodstream or deep wound are a serious complication of major surgeries, including cardiothoracic and orthopedic surgery, resulting in significant morbidity and mo... | all relevant data are within the paper and its supporting information files. introduction { # sec001 } = = = = = = = = = = = = * staphylococcus aureus * infections from the bloodstream or deep wound are causing serious complication of major surgeries, including cardiothoracic and orthopedic surgery, resulting in signif... | All relevant data are within the paper and its Supporting Information files. Introduction {# sec001} = = = = = = = = = = = = * Staphylococcus aureus * infections of the bloodstream or deep wound are a serious complication of major surgeries, including cardiothoracic and orthopedic surgery, resulting in significant morb... | All relevant data are within the paper and its Supporting files. Introduction ============ *Staphylococcus aureus* of the bloodstream or wound are a serious complication of major surgeries, including cardiothoracic and orthopedic surgery, resulting in significant morbidity and mortality \[[@pone.0147767.ref001], [@pone... | ALL ReLEvANt DATA aRE within the PAPER AND ITs sUPPoRtiNG INFoRMATioN fIleS.
IntrODUCtIoN {#SeC001}
============
*STapHyLOCoccus AurEus* infeCtIons OF the bLoodSTReAm oR DeEP WOund arE A seRioUS compLiCatION Of maJor sUrGERIES, IncLUDInG CARDIoThOrAcIc aNd OrThoPedIC sURGEry, rESULTinG In SignIFicANt MOrBIdiTy aNd mO... | All relevantdata are within the paper and itsSupporting Information files. Introduction {#sec001} ============ *Staphylococcus aureus* infections of the bloodstream or deep wound are a serious complication of major surgeries, including cardiothoracic and orthopedic surgery, resultingin significant ... | All _relevant_ data are within the paper and its Supporting Information files. Introduction _{#sec001}_ ============ *Staphylococcus aureus* _infections_ of the bloodstream _or_ deep _wound_ are a serious complication _of_ major surgeries, including _cardiothoracic_ and orthopedic surgery, _resulting_ _in_ significant ... |
Introduction
============
Sepsis-associated encephalopathy is defined as a diffuse cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct infectious involvement of the central nervous system \[[@B1]\]. Previous clinical observations have shown that the ... | introduction = = = = = = = = = = = = sepsis - associated encephalopathy is defined as a diffuse cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory signs of direct infectious involvement of the central nervous system \ [ [ @ b1 ] \ ]. previous clinical observations have... | Introduction = = = = = = = = = = = = Sepsis - associated encephalopathy is defined as a diffuse cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct infectious involvement of the centGzl nervous system \ [[ @ B1] \ ]. Previous clinical observations hav... | Introduction ============ Sepsis-associated encephalopathy is defined as a diffuse cerebral dysfunction induced by the systemic response to the infection without clinical or evidence of direct infectious involvement of the central nervous system \[[@B1]\]. Previous clinical observations have shown that the brain is oft... | INTrOductIon
============
SEpSis-asSOciated encEPHaLopathy IS dEFIneD as A DifFuSe Cerebral DYsFUNcTIon InduCEd By THE SysteMiC rESpONsE to tHE inFECtIon WITHout CliNicAl Or lABORAToRy EviDencE of DiRECT InFECtiouS INvOlveMEnt OF THe ceNTrAL NeRvoUS SYstEm \[[@b1]\]. pReviOUs cliNicAL obsErVATionS HavE SHoWN that thE ... | Introduction ============ Sepsis-associated encephalopathy is defined asa diffuse cerebral dysfunctioninduced by the systemic response to theinfectionwithout clinicalor laboratoryevidence of direct infectiousinvolvement of the centralnervous system \[[@B1]\]. Previous clinical observations have shown that the bra... | Introduction _============_ Sepsis-associated encephalopathy is defined as a _diffuse_ cerebral _dysfunction_ induced _by_ the systemic response to the infection _without_ clinical or laboratory evidence _of_ direct infectious involvement of the central nervous system \[[@B1]\]. Previous _clinical_ observations have sh... |
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Introduction
============
Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor, accounting for more than 50% of all gliomas. Despite aggressive surgery, chemotherapy and radiotherapy, the mean overall survival achieved for GBM patients is less than 18 months [@B1]. Consequently, sub... | introduction = = = = = = = = = = = = glioblastoma multiforme ( gbm ) is the most common and most aggressive primary brain tumor, accounting for more than 50 % of all gliomas. despite aggressive surgery, chemotherapy and radiotherapy, the mean overall survival achieved for gbm patients is less than 18 months [ @ b1 ]. c... | Introduction = = = = = = = = = = = = Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor, accounting for more than 50% of all gliomas. Despite aggressive surgery, chemotherapy and radiotherapy, the mean overall survival achieved for GBM patients is less than 18 months [@ B1 ]. Conse... | Introduction Glioblastoma multiforme (GBM) the most common and most aggressive primary brain tumor, accounting for more than 50% of all gliomas. Despite aggressive surgery, chemotherapy and the mean survival achieved for GBM patients is less than 18 months [@B1]. Consequently, substantial have been made in recent years... | INtRODuCTioN
============
GlioBLASTOMa mULtIFOrMe (GBm) Is ThE mOSt cOMmON ANd Most AGGResSIVe PRiMArY BRaiN TUmor, ACcouNtIng For MorE ThAN 50% oF All GLiomaS. desPITE aGgRESsivE sUrgEry, CHEMOtHEraPy And rADiOTHerApY, ThE MEAn OveRALl survIvAl AcHievED fOR gBm PaTIenTS iS Less tHaN 18 MoNths [@B1]. CoNsEqUeNtly, sUB... | Introduction ============Glioblastoma multiforme (GBM) is the mostcommon and most aggressive primary braintumor, accounting for more than 50% ofall gliomas. Despite aggressive surgery, chemotherapy and radiotherapy,the mean overall survival achieved for GBM patients is less than 18months [@B1].Consequently... | Introduction ============ Glioblastoma multiforme (GBM) _is_ the most _common_ and most aggressive primary _brain_ tumor, accounting _for_ more than 50% of all _gliomas._ Despite aggressive _surgery,_ chemotherapy and _radiotherapy,_ the mean overall survival achieved for GBM patients is less _than_ 18 months [@B1]. Co... |
Introduction {#Sec1}
============
Global seaweed production, largely derived from aquaculture (96.5 percent by volume of the wild-collected and cultivated aquatic plants combined), has changed considerably since 2005^[@CR1]^. This production increased from 13 million in 2005 to reach 30 million tons (live weight) in 2... | introduction { # sec1 } = = = = = = = = = = = = global seaweed production, largely derived from aquaculture ( 96. 5 percent by volume of the net - collected and cultivated aquatic plants combined ), has changed considerably since 2005 ^ [ @ cr1 ] ^. this production increased about 13 million in 2005 to reach 30 million... | Introduction {# Sec1} = = = = = = = = = = = = Global seaweed production, largely derived from aquaculture (96. 5 percent by volume of the wild - collected and cultivated aquatic plants combined ), has changed considerably since 2005 ^ [@ CR1] ^. This production incDeaser from 13 million in 2005 to reach 30 million tons... | Introduction {#Sec1} ============ Global seaweed production, largely derived from aquaculture (96.5 percent by volume of the wild-collected and cultivated aquatic plants combined), has changed considerably since 2005^[@CR1]^. This production increased from 13 million in 2005 to 30 million tons weight) in 2016. Moreover... | iNtROducTiOn {#sEc1}
============
GloBAl seAWeeD prOdUCtiON, lARGely DEriVed FROM AQUAcUltUrE (96.5 percent BY VolUME Of thE wilD-coLlEcTed and CUlTIvATeD AquAtiC PLaNtS cOMBiNED), HAS ChangEd considerAblY siNCE 2005^[@cR1]^. thiS pRODuCTIOn InCREASed fRoM 13 miLlIon IN 2005 to ReacH 30 MILLIoN tonS (lIve weIghT) in 2... | Introduction {#Sec1} ============ Global seaweed production, largely derived from aquaculture (96.5 percent by volume of the wild-collected and cultivated aquatic plants combined), has changed considerably since 2005^[@CR1]^. This production increased from 13 million in 2005 to reach30 million tons ... | Introduction {#Sec1} ============ _Global_ seaweed production, largely derived from aquaculture (96.5 percent by volume _of_ the wild-collected and cultivated aquatic plants combined), has changed considerably _since_ _2005^[@CR1]^._ This production _increased_ from _13_ million _in_ _2005_ to _reach_ _30_ million tons... |
Introduction {#Sec1}
============
Some of the low level radioactive waste (LLW) from reprocessing of spent nuclear fuel is planned to be disposed of in a purpose built repository at a depth of more than 300 m in the geosphere (geological disposal). In such LLW, nitrates can be present in the form of soluble salts and ... | introduction { # sec1 } = = = = = = = = = = = = some of the low level radioactive waste ( llw ) from reprocessing of spent nuclear fuel is planned to be disposed of in a purpose built repository at a depth of more than 300 m in tokyo geosphere ( geological disposal ). in such llw, nitrates can readily present in the fo... | Introduction {# Sec1} = = = = = = = = = = = = Some of the low level radioactive waste (LLW) from reprocessing of spent nuclear fuel is planned to be disposed of in a purpose built repository at a depth of more than 300 m in the geosphere (geological disposal ). In such LLW, nitrates can be present in the form of solubl... | Introduction {#Sec1} ============ Some of the low level radioactive waste from reprocessing of spent nuclear fuel is planned to be disposed of in a purpose repository at a depth of more than 300 m in the geosphere (geological disposal). In such LLW, nitrates can present in the of soluble salts and change to various red... | INtRodUCTiOn {#Sec1}
============
sOMe Of the loW LeveL raDIoActive WAstE (lLW) FROM REPROCeSSing OF SPenT nuCLeAR fUeL iS pLANnED tO be DiSPoSEd oF In a pURpOse Built RepOSiTory At A DEpTh OF MOrE THan 300 m IN THe geospHeRe (GEoLogiCAL diSPOSaL). iN sUCh LlW, nitrATes caN be prESENt IN tHe fORM of sOLUblE SaLts anD ... | Introduction {#Sec1}============ Some of the low level radioactive waste (LLW) fromreprocessing of spent nuclear fuelis planned to be disposed of in apurpose built repository at a depth of more than300 m in the geosphere (geological disposal). In such LLW, nitrates can be present in the form ofsoluble salt... | _Introduction_ {#Sec1} _============_ _Some_ _of_ the low level radioactive waste (LLW) from reprocessing of spent nuclear _fuel_ is planned to be disposed _of_ _in_ a purpose built repository at _a_ depth of more than 300 _m_ _in_ the geosphere (geological disposal). _In_ such LLW, _nitrates_ can _be_ _present_ in _th... |
Introduction
============
Aerosol transmission of *Mycobacterium tuberculosis* during active pulmonary disease results in exposure of a substantial proportion of the global population, although only a fraction of individuals develop clinical tuberculosis (de Jong *et al*., [@b11]). Based on priming of an antigen-speci... | introduction = = = = = = = = = = = = aerosol transmission of * mycobacterium tuberculosis * during active pulmonary disease results in exposure of a substantial proportion of infected global population, although only a fraction of individuals develop clinical tuberculosis ( de jong * et al *., [ @ b11 ] ). based on pri... | Introduction = = = = = = = = = = = = Aerosol transmission of * Mydobactegium tuberculosis * during active pulmonary disease results in exposure of a substantial proportion of the global population, although only a fraction of individuals develop clinical tuberculosis (de Jong * et al *. , [@ b11] ). Based on priming of... | Introduction ============ Aerosol transmission of *Mycobacterium tuberculosis* during active pulmonary disease results in exposure of a substantial proportion of the global population, although only a fraction of individuals develop clinical tuberculosis (de Jong al*., [@b11]). Based on priming of an antigen-specific r... | inTrODUCTiON
============
aERoSOl TRaNsmIssION OF *MYcOBacteRIUm tUbERcUloSis* duRING aCTIVe PuLmonarY DISEAsE reSuLTS iN ExPOSUre OF a SubstaNtiaL PropOrtION OF the GLoBal pOPULAtIon, alThougH onLy a fracTion Of IndIVIduals dEVeLoP clINiCal tUBERCulOSiS (DE JoNG *eT Al*., [@B11]). BAsEd On PrimINg of AN aNtIgEN-sPeCi... | Introduction============ Aerosol transmissionof *Mycobacterium tuberculosis* during active pulmonary disease results inexposure of a substantial proportionof the global population, although only a fraction ofindividualsdevelop clinical tuberculosis (de Jong *et al*., [@b11]). Based on primingof an antigen... | Introduction ============ Aerosol _transmission_ of _*Mycobacterium_ tuberculosis* during active _pulmonary_ disease results in _exposure_ _of_ a _substantial_ proportion of the global population, although only a _fraction_ of _individuals_ develop clinical tuberculosis (de Jong *et al*., [@b11]). Based _on_ _priming_ ... |
1. Introduction {#sec1-nutrients-09-00576}
===============
A one-day workshop was convened in Marrakesh (Morocco) in October 2016 to discuss issues around iron interventions in Africa, with a focus on iron fortification. Iron deficiency (ID) is the most common nutritional disorder in the world and estimates have attri... | 1. introduction { # sec1 - nutrient - 09 - 00576 } = = = = = = = = = = = = = = = a one - day workshop was convened in marrakesh ( morocco ) in october 2016 to discuss issues around iron interventions in africa, with a focus on iron fortification. aluminum deficiency ( id ) is the most common nutritional disorder in the... | 1. IntrocuctioH {# sec1 - nutrients - 09 - 00576} = = = = = = = = = = = = = = = A one - day workshop was convened in Marrakesh (Morocco) in October 2016 to discuss issues around iron interventions in Africa, with a focus on iron fortification. Iron deficiency (ID) is the most common nutritional disorder in the world an... | 1. Introduction {#sec1-nutrients-09-00576} =============== one-day workshop was convened in Marrakesh in October 2016 to discuss issues around iron interventions in Africa, with a focus on fortification. Iron deficiency (ID) is the most common nutritional disorder in the world and estimates have attributed about the ca... | 1. iNTrODUcTiOn {#sec1-NutRiENts-09-00576}
===============
A ONE-DAy woRksHOP WAS CoNvened IN mArraKESh (MOroCCO) in OCtoBeR 2016 to DIsCUsS ISsUEs AROuND iROn iNTERVENTIons IN afRIcA, WItH a FOCus on irOn FORtIFIcaTiON. Iron dEficieNcY (ID) IS The mOst CommoN NUtrItionAL dIsORder iN ThE world ANd ESTiMAtes HAVe attRi... | 1. Introduction {#sec1-nutrients-09-00576} =============== A one-dayworkshopwas convened in Marrakesh (Morocco) in October 2016 to discuss issues around iron interventions inAfrica, with a focus on iron fortification. Iron deficiency (ID) is the most commonnutritional disorder in the world and estimates have at... | 1. _Introduction_ {#sec1-nutrients-09-00576} =============== A one-day workshop was convened in Marrakesh (Morocco) in October 2016 to _discuss_ issues around iron interventions in _Africa,_ with a focus on iron _fortification._ Iron deficiency _(ID)_ is the most common nutritional disorder _in_ _the_ world _and_ estim... |
Introduction {#s1}
============
Enterococci are official fecal indicator bacteria (FIB) in many countries for determining the bathing water quality and monitoring with the intention to protect swimmers from exposure to enteric pathogens ([@B1], [@B2]). An ideal FIB has a similar decay rate to enteric pathogens ([@B3])... | introduction { # s1 } = = = = = = = = = = = = enterococci are official fecal indicator bacteria ( fib ) and many countries for determining the bathing water quality and monitoring with the effort to protect swimmers from exposure to enteric pathogens ( [ @ b1 ], [ @ b2 ] ). an ideal fib has comparatively similar decay ... | Introduction {# s1} = = = = = = = = = = = = Enterococci are official fecal indicator bacteria (FIB) in many countries for determining the bathing water quality and monitoring with the intention to protect swimmers from exposure to enteric pathogens ([ @ B1 ], [@ B2] ). An ideal FIB has a similar decay rate to enteric p... | Introduction {#s1} ============ Enterococci are indicator bacteria (FIB) many countries for determining bathing water quality and monitoring with intention to protect swimmers from to enteric pathogens ([@B1], [@B2]). An FIB has a similar decay rate to enteric pathogens ([@B3]). However, the wide taxonomic of microbes ... | INTROductiON {#S1}
============
ENtErOcOCcI ARe OFFICIal feCaL inDICAtOr bAcTEriA (FiB) iN mANY CoUNTrIES FoR dETeRminiNG ThE bAthinG WAteR qUAlity And MOnitOrING with thE iNteNTiOn TO PRotECT sWIMmers FROM EXposURE to ENTErIC patHoGens ([@B1], [@B2]). AN IDEAL fib hAS a SIMilAR DEcAy RaTE to entEriC paThOgens ([@b3])... | Introduction {#s1} ============ Enterococci are officialfecal indicatorbacteria (FIB) in many countries for determiningthe bathing water quality and monitoring with the intention to protect swimmers from exposure to enteric pathogens ([@B1], [@B2]).An ideal FIB has a similar decay rateto enteric pathogens... | _Introduction_ {#s1} ============ Enterococci are official fecal indicator _bacteria_ (FIB) _in_ many _countries_ for _determining_ _the_ _bathing_ water quality _and_ monitoring with the _intention_ _to_ protect _swimmers_ from _exposure_ to enteric pathogens ([@B1], [@B2]). _An_ ideal FIB _has_ _a_ similar decay _rat... |
EUS-guided biliary drainage has been widely attempted for failed endoscopic retrograde cholangiopancreatography.\[[@ref1][@ref2]\] For patients with surgically altered anatomy such as the Roux-en-Y procedure, EUS-guided hepaticojejunostomy (HJS) is performed. A covered self-expandable metal stent with a long length is ... | eus - guided biliary insertion has been widely attempted for failed endoscopic retrograde cholangiopancreatography. \ [ [ @ ref1 ] [ @ ref2 ] \ ] for people with surgically altered anatomy such as the roux - en - y procedure, eus - guided hepaticojejunostomy ( hjs ) is performed. a covered self - expandable metal stent... | EUS - guided biliary drainage has been widely attempted for failed endoscopic retrograde cholangiopancreatography. \ [[ @ ref1] [@ ref2] \] For patients with surgically altered anatomy s7cJ as the Roux - en - Y procedure, EUS - guided hepaticojejunostomy (HJS) is performed. A covered self - expandable metal stent with ... | EUS-guided biliary drainage has been widely for failed endoscopic retrograde For patients surgically altered such as the Roux-en-Y procedure, EUS-guided hepaticojejunostomy (HJS) is performed. A covered self-expandable stent with a long length is normally used as an stent to prevent stent migration,\[[@ref3][@ref4]\] b... | EUs-gUIdED BiliARy drAINAge has bEeN WIDeLY aTtEMpTeD For faIled enDoSCopIC ReTroGradE CHOLANGiOpaNCrEaTOGrapHy.\[[@Ref1][@REf2]\] For PAtIENTS WITh SuRgiCaLLy AlTEReD anATomy sucH AS tHE RoUX-en-Y PrOCeDUrE, eus-gUIdEd hePATICoJEJUnOStoMy (Hjs) iS perFOrmeD. a cOVeRed SELF-ExpaNDABle MeTaL STEnt wITH A LOng lEnGtH IS ... | EUS-guided biliarydrainagehas been widely attempted for failed endoscopic retrograde cholangiopancreatography.\[[@ref1][@ref2]\] For patients withsurgically altered anatomy such as the Roux-en-Y procedure, EUS-guidedhepaticojejunostomy (HJS) isperformed. A covered self-expandable metal stent with a long lengt... | _EUS-guided_ _biliary_ drainage has _been_ widely attempted _for_ _failed_ _endoscopic_ retrograde cholangiopancreatography.\[[@ref1][@ref2]\] _For_ patients _with_ _surgically_ _altered_ anatomy such _as_ the Roux-en-Y procedure, EUS-guided hepaticojejunostomy (HJS) is performed. A covered self-expandable metal stent ... |
Introduction
============
Transcatheter aortic valve implantation (TAVI) is an established treatment of severe aortic stenosis for elderly patients with high and intermediate surgical risk.[@suaa098-B1]^,^[@suaa098-B2] Ongoing studies aim to expand the indications for TAVI towards patients with lower risk, younger age... | introduction = = = = = = = = = = = = transcatheter aortic valve implantation ( tavi ) is an established treatment of severe aortic stenosis for elderly patients with high and intermediate surgical risk. [ @ suaa098 - b1 ] ^, ^ [ @ suaa098 - b2 ] ongoing studies aim to expand the indications for tavi towards patients wi... | Introduction = = = = = = = = = = = = Transcatheter aortic valve implantation (TAVI) is an established treatment of severe aortic stenosis for elderly patients with high and intermediate surgical risk. [@ suaa098 - B1] ^, ^ [@ suaa098 - B2] Ongoing studies aim to expand the indications for TAVI towards patients with low... | Introduction ============ Transcatheter valve implantation (TAVI) an established treatment severe aortic stenosis for elderly patients with high and intermediate surgical risk.[@suaa098-B1]^,^[@suaa098-B2] Ongoing aim expand the indications for TAVI towards patients lower risk, younger age, bicuspid anatomy, or even no... | IntRoDUCtion
============
TraNScATHetER aoRTIC valvE ImPlANtatIoN (Tavi) Is aN EStAblisHed TrEaTmEnT of SeVeRE AOrTIC stENoSIS FOr ElderLy pAtIEnTs WiTh hIgh anD INTErMedIAte SurgicAL RisK.[@sUAA098-B1]^,^[@suAA098-B2] ONGOInG STudIes aIM To Expand THe iNDIcATIOnS fOr Tavi tOwaRDS pAtIEnts WitH lOWeR RisK, youngeR aGE... | Introduction ============ Transcatheter aortic valve implantation (TAVI)is an established treatment of severe aorticstenosisfor elderly patients with high and intermediate surgical risk.[@suaa098-B1]^,^[@suaa098-B2] Ongoing studiesaim to expandtheindications for TAVI towards patients with lower risk, younger ... | _Introduction_ ============ _Transcatheter_ aortic valve implantation (TAVI) _is_ an established _treatment_ _of_ _severe_ _aortic_ stenosis for elderly _patients_ with high and intermediate surgical _risk.[@suaa098-B1]^,^[@suaa098-B2]_ Ongoing studies aim to expand the indications _for_ TAVI towards patients with lowe... |
Despite major advances in early detection and treatment, breast cancer remains the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide. Strategies targeting the primary tumour have markedly improved in the past decade, but systemic treatments to prevent metastasis are less effectiv... | despite major advances in early detection and treatment, breast cancer remains the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide. strategies targeting acute primary tumour have markedly improved in the past decade, but systemic treatments to prevent metastasis are less effect... | Despite major advances in early detection and treatment, breast cancer remains the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide. Strategies targeting the primary tumour have markedly improved in the past decade, but systemic treatments to prevent metastasis are less effectiv... | Despite major advances in early detection and treatment, breast cancer remains the most frequently diagnosed cancer and the leading of cancer death in women worldwide. Strategies targeting the primary tumour have markedly in the past decade, but treatments to prevent metastasis are less effective, and about 20%--30% of... | Despite MAJoR adVancEs In EaRly detEctIOn aND TreatMEnt, BreasT CancEr REmainS tHe moSt frEQuENtLY DiagNosed canCer AnD thE lEaDinG cAUSe Of cAnCEr deAth In wOMEn WorlDwiDE. sTRATegiEs TarGeTING the pRiMary TUmoUR HAVE mArkEdly ImpROVeD in THE paSt dEcAde, bUt sysTemIc tReaTmeNTS to PRevEnT mEtAsTasiS arE LesS EffECTiv... | Despite major advances in early detection and treatment, breastcancer remainsthe most frequently diagnosed cancerand the leading cause of cancerdeath in women worldwide. Strategies targeting the primarytumour have markedly improved in the past decade, but systemictreatmentsto prevent metastasisareless... | Despite _major_ advances _in_ early detection and treatment, breast cancer remains the most frequently _diagnosed_ cancer and the leading cause of cancer death in women worldwide. Strategies targeting the primary tumour have _markedly_ improved in the past decade, but _systemic_ treatments to prevent metastasis _are_ l... |
{#sp1 .320}
| ! [ ] ( alpha - 2 ) { # 1. 320 } | ! [] (indmrdgaz73299 - 0050) {# sp1. 320 } | {#sp1 .320}
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Introduction {#ss1}
============
Diabetes is increasing in Japan to levels that are comparable with those of other countries, and a recent publication reported that the number of individuals 'strongly suspected of having diabetes' in Japan was approximately 8.9 million in 2007[^1^](#b1){ref-type="ref"}. Type 2 diabete... | introduction { # ss1 } = = = = = = = = = = = = diabetes is increasing in addition to levels that are comparable with those of other countries, and a recent publication found that the number of individuals ' strongly suspected of having diabetes ' in japan was approximately 8. 9 million in 2007 [ ^ 1 ^ ] ( # b1 ) { ref ... | Introduction {# ss1} = = = = = = = = = = = = Diabetes is increasing in Japan to levels that are comparable with those of other countries, and a recent publication reported that the number of individuals ' strongly suspected of having diabetes ' in Japan was approximately 8. 9 million in 2007 [^ 1 ^] (# b1) {ref - type ... | Introduction {#ss1} ============ Diabetes is increasing in Japan to levels that are comparable with those of other countries, and a recent publication that the number of individuals 'strongly suspected of having diabetes' in Japan approximately million in 2007[^1^](#b1){ref-type="ref"}. Type 2 diabetes is characterized... | INTrOdUCtIOn {#SS1}
============
diABEtEs is INcREaSinG In jApAn tO lEvELS ThaT ARE CoMPaRable WItH THOsE oF otHer cOUNTRieS, and A reCEnT pUblICaTIoN rePorTed tHAt tHE NumBEr Of iNDIViduAls 'StRoNgly suspECteD OF havINg diAbetes' in jApAN WAs ApPrOXImaTeLY 8.9 miLLioN iN 2007[^1^](#b1){rEF-tyPE="ref"}. tyPE 2 Diabete... | Introduction {#ss1} ============ Diabetes is increasing in Japan to levels thatare comparablewith those of other countries, and a recent publication reported thatthe number of individuals 'stronglysuspected ofhaving diabetes' in Japan was approximately 8.9 million in 2007[^1^](#b1){ref-type="ref"}. Type 2 diabetes ... | Introduction {#ss1} ============ Diabetes is increasing _in_ Japan to levels that are comparable with those of other countries, and a recent publication _reported_ that _the_ _number_ of individuals 'strongly _suspected_ of _having_ diabetes' _in_ Japan was approximately 8.9 million in 2007[^1^](#b1){ref-type="ref"}. _... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
There is a growing interest in the patterns and processes associated with geographical variation in population genetic structure across species' ranges since these often shift, expand and contract over tim... | all relevant data are within the paper and its supporting information files. introduction { # data } = = = = = = = = = = = = there is a growing interest in the patterns and processes associated with geographical variation in population genetic structure across species ' ranges since these often shift, expand and contra... | All relevant data are within the paper and its Supporting Information files. Introduction {# sec001} = = = = = = = = = = = = There is a growing interest in the patterns and processes associated with geographical variation in population genetic structure across species ' ranges since these often shift, expand and contra... | relevant data are within the paper and its Supporting Information Introduction {#sec001} ============ There is a growing interest in the patterns and processes associated with geographical variation in population genetic structure across species' ranges since often expand and contract over time \[[@pone.0117113.ref001]... | ALL RelEVant DATA are WITHIn ThE PApeR aNd iTs sUPPOrtInG iNFORmaTIOn fileS.
inTRoduCtiOn {#sEc001}
============
ThERe iS a grOwINg intEREst IN THE patTErns and PrOcEsses aSsoCiATed wIth GeoGrAPHiCaL variaTION in PoPULatIon GeneTIc sTruCtuRE aCROSs sPEciES' rAnGES SInce these OFTEn ShIfT, eXPaND AND coNTRacT OVer tiM... | All relevant dataare within the paperand its Supporting Information files. Introduction{#sec001} ============ There is a growing interest in the patterns and processes associated withgeographical variationin population genetic structure across species' ranges since these often shift,expand andcontract ove... | All relevant data are within the paper _and_ its Supporting Information files. _Introduction_ {#sec001} ============ There _is_ a _growing_ interest in the _patterns_ and processes associated with geographical _variation_ in _population_ genetic structure across _species'_ ranges since these often shift, expand and _co... |
INTRODUCTION {#s1}
============
Invasive cervical cancer (ICC) is the fourth most common malignancy among women worldwide, with an estimated 528,000 new cases and 266,000 deaths in 2012 and with 87% of cervical cancer deaths occurring in less developed regions \[[@R1]\]. Among Mexican women, ICC is the second most com... | introduction { # s1 } = = = = = = = = = = = = invasive cervical cancer ( icc ) is the fourth most common malignancy among women worldwide, with an estimated 528, 000 new cases and 266, 000 deaths in 2012 and with 87 % of cervical cancer deaths occurring in less developed regions \ [ [ @ r1 ] \ ]. among mexican women, i... | INTRODUCTION {# s1} = = = = = = = = = = = = Invasive cervical cancer (ICC) is the fourth most common malignancy among women worldwide, with an estimated 528, 000 new cases and 266, 000 deaths in 2012 and with 87% of cervical cancer deaths occurring in less developed regions \ [[ @ R1] \ ]. Among Mexican women, ICC is t... | INTRODUCTION ============ Invasive cervical cancer is the fourth most common malignancy among women worldwide, with an estimated 528,000 new cases and 266,000 deaths in 2012 and with 87% of cervical cancer deaths occurring in less developed \[[@R1]\]. Among Mexican women, ICC second most common neoplasia, just after br... | IntRODuCTiOn {#S1}
============
invASIVe CErviCAL caNCER (icC) iS tHE fouRTH moSt CoMMon malIgNANCy amONg WOMEn wORlDwIDE, WITH AN ESTIMatED 528,000 nEW Cases ANd 266,000 deAths in 2012 AnD wiTH 87% oF cERvIcAL cancer deatHS occURRINg iN LeSs DEVELOpED rEgIONS \[[@r1]\]. among mexican WOMen, iCC IS The sEconD mosT com... | INTRODUCTION {#s1} ============ Invasive cervical cancer (ICC) is the fourth most common malignancy among women worldwide, with an estimated 528,000 new cases and 266,000 deaths in 2012 and with 87% of cervical cancer deaths occurring in less developed regions \[[@R1]\]. AmongMexicanwomen, ICC is ... | INTRODUCTION {#s1} ============ Invasive cervical cancer (ICC) is the fourth most common malignancy among women worldwide, with an estimated _528,000_ new cases and 266,000 deaths in 2012 and with 87% of cervical cancer _deaths_ occurring in less developed regions \[[@R1]\]. Among Mexican women, _ICC_ is the _second_ m... |
Introduction {#Sec1}
============
M*ycobacterium leprae* is the main causative agent of leprosy, a disease that affects the skin, nerves, and mucosa of the upper respiratory tract in humans^[@CR1]^. A second, distantly related leprosy bacillus, *Mycobacterium lepromatosis*, was recently discovered in humans and red sq... | introduction { # sec1 } = = = = = = = = = = = = m * ycobacterium leprae * is the main causative agent of leprosy, a disease that affects the skin, nerves, and mucosa affecting the upper respiratory tract in humans ^ [ @ cr1 ] ^. a second, distantly related leprosy bacillus, * mycobacterium lepromatosis *, was recently ... | Introduction {# Sec1} = = = = = = = = = = = = M * ycobacterium leprae * is the main causative agent of leprosy, a disease that affects the skin, nerves, and mucosa of the upper respiratory tract in humans ^ [@ CR1] ^. A second, distantly related leprosy bacillus, * Mycobacterium lepromatosis *, was recently discovered ... | Introduction {#Sec1} ============ M*ycobacterium leprae* is main causative agent of leprosy, a that affects the skin, nerves, and mucosa of the upper tract in humans^[@CR1]^. A second, distantly related leprosy *Mycobacterium lepromatosis*, was recently discovered in and red squirrels (*Sciurus vulgaris*)^[@CR2]^. Lepr... | INtrOdUctIon {#SEC1}
============
m*ycObACTeRium LEPrAE* IS THe main CAUSaTiVe agEnT oF lepROSy, a DISEAsE that AFFeCts THE sKIn, neRVEs, AND MuCoSA oF tHe UpPer REspiRaToRY TrAcT in huMaNs^[@cR1]^. a sEcOND, disTaNtly RElaTED LePROSy BACIllUs, *MycoBacTeRIUM lEprOMAToSiS*, wAs reCeNTLy dIScoVEReD iN HUMans and Red sq... | Introduction {#Sec1} ============ M*ycobacterium leprae* is the main causative agent of leprosy, a disease that affects the skin, nerves, and mucosa of the upper respiratory tract in humans^[@CR1]^. A second,distantly related leprosy bacillus, *Mycobacterium lepromatosis*, was recently discovered ... | _Introduction_ {#Sec1} _============_ M*ycobacterium leprae* is the main causative agent of leprosy, a _disease_ _that_ affects _the_ skin, nerves, and mucosa _of_ the upper respiratory tract in humans^[@CR1]^. A second, distantly related leprosy bacillus, *Mycobacterium lepromatosis*, was recently _discovered_ in _hum... |
INTRODUCTION {#s1}
============
Bladder cancer (BC) is the 9th most common cancer worldwide, and the 4th most common cancer in more developed world \[[@R1]--[@R3]\]. In the last years, BC risk has been linked to the smoking, to the occupational exposures \[[@R4]\], to the use of drugs like cyclophosphamide or chlornap... | introduction { # s1 } = = = = = = = = = = = = bladder cancer ( bc ) is the 9th least common cancer worldwide, and the 4th most common cancer in more developed world \ [ [ @ r1 ] - - [ @ r3 ] \ ]. in the last years, bc risk has been linked to the smoking, during the occupational exposures \ [ [ @ r4 ] \ ], to the use of... | INTRODUCTION {# s1} = = = = = = = = = = = = Bladder cancer (BC) is the 9th most common cancer worldwide, and the 4th most common cancer in more developed world \ [[ @ R1] - - [@ R3] \ ]. In the last years, BC risk has been linked to the smoking, to the occupational exposures \ [[ @ R4] \ ], to the use of drugs like cyc... | INTRODUCTION {#s1} ============ Bladder cancer (BC) is the 9th common cancer worldwide, and the 4th most common in more developed world \[[@R1]--[@R3]\]. In the last years, BC risk has been linked to the smoking, to the occupational exposures \[[@R4]\], to the of drugs like cyclophosphamide or chlornaphazine \[[@R5]\],... | INTRoDuctION {#S1}
============
blaDDEr CancEr (bc) Is THE 9Th mOst cOmmoN Cancer WorlDWIDe, AnD thE 4th MOst coMMoN cancer IN mOrE devELopeD worLd \[[@R1]--[@r3]\]. iN the lASt yEArs, BC rISk Has beEN LiNKed To The SMOKiNG, TO THE occUPATIoNAL ExposurES \[[@r4]\], to tHE usE OF DruGs lIkE CYcLoPHospHAMide oR cHLOrnap... | INTRODUCTION {#s1} ============ Bladder cancer (BC) is the 9th most common cancerworldwide, and the 4th most commoncancer in more developed world \[[@R1]--[@R3]\].In thelast years, BC risk has been linked to the smoking, totheoccupational exposures \[[@R4]\], to the use of drugs like cyclophosphamide ... | INTRODUCTION {#s1} ============ Bladder cancer (BC) is the 9th _most_ common cancer worldwide, _and_ the 4th most common _cancer_ _in_ more _developed_ world \[[@R1]--[@R3]\]. In _the_ _last_ years, BC risk has been _linked_ to the smoking, to the occupational exposures \[[@R4]\], to the use of _drugs_ like cyclophosph... |
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