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RS-1: Pediatric dosimetry of
18
F-FDG whole body PET/CT scans
**Aruna Kaushik, Anupam Mondal^1^, Rajnish Sharma^1^, Maria D'Souza^1^, Abhinav Jaimini^1^, Dinesh Singh^1^, Anjani Tiwari, AK Mishra, BS Dwarakanath^2^**
Division of Cyclotron and Radiopharmaceutical Sciences, ^1^Division of PET Imaging, ^2^Division of ... | source - 1 : pediatric dosimetry of 18 f - fdg whole body pet / ct scans * * aruna kaushik, anupam mondal ^ 1 ^, rajnish sharma ^ 1 ^, maria d ' souza ^ 1 ^, abhinav jaimini ^ 1 ^, dinesh singh ^ 1 ^, anjani tiwari, ak mishra, bs dwarakanath ^ 2 ^ * * division of cyclotron and radiopharmaceutical sciences, ^ 1 ^ advanc... | RS - 1: Pediatric dosimetry of 18 F - FDG whole body PET / CT scans * * Aruna Kaushik, Anupam Mondal ^ 1 ^, Rajnish Sharma ^ 1 ^, Maria D ' Souza ^ 1 ^, Abhinav Jaimini ^ 1 ^, Dinesh Singh ^ 1 ^, Anjani Tiwari, AK Mishra, BS Dwarakanath ^ 2 ^ * * Division of Cyclotron and Radiopharmaceutical Sciences, ^ 1 ^ Division of... | RS-1: Pediatric dosimetry of 18 F-FDG whole body PET/CT scans **Aruna Kaushik, Anupam Rajnish Sharma^1^, Maria D'Souza^1^, Abhinav Jaimini^1^, Dinesh Singh^1^, Anjani AK BS Dwarakanath^2^** Division of Cyclotron and Radiopharmaceutical Sciences, ^1^Division of PET Imaging, ^2^Division of Radiation Biosciences, Institut... | rS-1: pEDiATRIC DOsimEtrY Of
18
F-FDG WHOLE bOdy pet/Ct sCANS
**aRuNA KAUSHIK, aNUPaM mONDAl^1^, rajnish ShARMa^1^, mARIA d'sOuZa^1^, aBhInaV JaiminI^1^, dINEsH SiNgH^1^, ANJanI Tiwari, AK miShRA, bS dwARAkanATH^2^**
DiviSiOn oF cyclOtron AND RadIophArMaCEutiCaL sCIeNCeS, ^1^divIsIoN OF pet IMaGINg, ^2^dIVisiON oF ... | RS-1: Pediatric dosimetryof 18 F-FDG whole body PET/CT scans **Aruna Kaushik, Anupam Mondal^1^, Rajnish Sharma^1^, Maria D'Souza^1^, Abhinav Jaimini^1^, Dinesh Singh^1^, Anjani Tiwari, AKMishra, BS Dwarakanath^2^** Division of Cyclotron and Radiopharmaceutical Sciences, ^1^Division of PET Imaging, ^... | RS-1: _Pediatric_ dosimetry of _18_ F-FDG whole body PET/CT scans **Aruna _Kaushik,_ _Anupam_ _Mondal^1^,_ Rajnish _Sharma^1^,_ Maria D'Souza^1^, _Abhinav_ Jaimini^1^, _Dinesh_ Singh^1^, _Anjani_ Tiwari, AK Mishra, BS Dwarakanath^2^** Division _of_ Cyclotron _and_ Radiopharmaceutical Sciences, ^1^Division of PET _Imagi... |
Introduction {#Sec1}
============
Band structure engineering and low-loss propagation of information-carrying entities are the cornerstones of both electronics and magnonics. Whereas electronics exploits dissipative transfer of electric charges, magnonics is based on low-energy transport of angular momentum in the for... | introduction { # sec1 } = = = = = = = = = = = = band structure engineering and low - loss propagation of information - carrying entities are the cornerstones of both electronics and magnonics. whereas electronics exploits dissipative transfer of electric charges, magnonics is based on low - energy transport of angular ... | Introduction {# Sec1} = = = = = = = = = = = = Band structure engineering and low - loss propagation of information - carrying entities are the cornerstones of both electronics and magnonics. Whereas electronics exploits dissipative transfer of electric charges, magnonics is based on low - energy transport of angular mo... | Introduction {#Sec1} ============ structure engineering and propagation of information-carrying entities are the cornerstones of both electronics magnonics. Whereas electronics exploits dissipative transfer of electric charges, magnonics is based on low-energy transport of angular momentum in the form of spin waves. Ac... | iNtroDucTIon {#Sec1}
============
BAND StRucTUre EnGineErING aNd low-Loss propaGatiON Of INfoRmatioN-cArrYInG ENtiTIEs ArE The CorNerStONeS of BOtH ELECtroNiCs ANd MaGNoNiCS. WHEREAs ELEctRonICS eXploitS DISSIPatIVE TrANSFER OF eleCtriC ChARGEs, MagnONiCS is BAsED ON loW-ENeRGY transPoRT oF AnGular Momentum in THE foR... | Introduction {#Sec1} ============ Band structure engineering and low-loss propagation of information-carryingentities are the cornerstones of both electronics andmagnonics. Whereaselectronicsexploits dissipative transfer of electric charges, magnonics is based on low-energy transport of angular momentum in the fo... | Introduction {#Sec1} ============ Band structure engineering and low-loss propagation of information-carrying entities _are_ the cornerstones of both electronics _and_ magnonics. Whereas electronics exploits dissipative transfer of electric _charges,_ magnonics is based on low-energy transport of angular _momentum_ in ... |
Introduction {#s1}
============
Understanding the factors that set species geographical borders is a central issue in ecology and evolutionary biology [@pone.0092177-Gaston1] that has received increased attention in the face of the rapid distributional shifts associated with climate change. All species have limits to ... | introduction { # s1 } = = = = = = = = = = = = understanding the factors that set species geographical differences is a central issue in ecology and evolutionary biology [ @ pone. 0092177 - gaston1 ] that has received increased attention in the face of the rapid distributional shifts associated with climate change. all ... | Introduction {# s1} = = = = = = = = = = = = Understanding the facRorQ that set species geographical borders is a central issue in ecology and evolutionary biology [@ pone. 0092177 - Gaston1] that has received increased attention in the face of the rapid distributional shifts associated with climate chanvr. All species ... | Introduction ============ Understanding the factors that set species geographical borders is central issue in ecology and evolutionary biology [@pone.0092177-Gaston1] that has received increased in the face of the rapid distributional shifts with climate change. All species have limits to their geographical ranges beyo... | InTRODuCtIon {#S1}
============
UnDERStANdINg tHe fAcTORS ThaT SEt SpEciES GEographICaL borDERs IS A cEnTRal ISSuE iN ecoLoGy And eVoluTioNArY BIologY [@pONe.0092177-gASton1] thaT HAs rECeivED INCREAsEd aTtenTIon IN The Face Of The RAPID DIstRiBuTIOnAl SHIfTS AsSocIATed wIth CLimATe CHaNge. ALl SPeciEs HavE LIMIts tO ... | Introduction {#s1} ============ Understanding the factors that set species geographical bordersis a central issue in ecology and evolutionary biology [@pone.0092177-Gaston1] that has received increasedattention in the face of the rapid distributional shifts associated with climatechange. All specie... | Introduction {#s1} ============ Understanding the _factors_ that set species geographical borders _is_ _a_ central issue in ecology and evolutionary biology [@pone.0092177-Gaston1] that has received _increased_ attention in _the_ face of the _rapid_ distributional shifts associated with climate change. All _species_ _h... |
Introduction {#s1}
============
Accurate identification of the translation initiation codon in mRNA by ribosomes is crucial for expression of the correct cellular proteins. This process generally occurs in eukaryotic cells by a scanning mechanism, wherein the small (40S) ribosomal subunit recruits charged initiator tR... | introduction { # s1 } = = = = = = = = = = = = accurate identification of the translation initiation codon in mrna by ribosomes is crucial for expression of the correct cellular proteins. this process generally occurs in eukaryotic cells by a scanning mechanism, wherein the small ( 40s ) ribosomal subunit recruits prote... | Introduction {# s1} = = = = = = = = = = = = Accurate identification of the translation initiation codon in mRNA by ribosomes is crucial for expression of the correct cellular proteins. Ghls process generally occurs in eukaryotic cells by a scanning mechanism, wherein the small (40S) ribosomal subunit recruits charged i... | Introduction ============ Accurate identification of translation initiation codon in mRNA by ribosomes is crucial for expression of the correct cellular proteins. This process generally occurs in eukaryotic cells by a scanning mechanism, wherein the small (40S) ribosomal subunit recruits charged initiator tRNA (Met-tRN... | iNtRodUCtiOn {#s1}
============
AccUrAtE idenTIfICAtIOn OF ThE tRanSLAtion initIatIoN COdON In MrNA By rIBOsOmES IS CruCIAL FoR EXpREsSIon OF tHe CorReCt cElluLAR PRoTeInS. tHIs procesS geNeRAlLY ocCURs iN eUkaRYOtIc CEllS bY A scanning MecHANIsM, WHeReiN thE SmALL (40s) rIboSoMAl suBuNIt RecRUIts cHaRGeD INItiaTOr tR... | Introduction{#s1} ============ Accurate identificationofthe translation initiationcodon in mRNA by ribosomes iscrucial for expression of the correct cellular proteins. This process generallyoccurs in eukaryotic cells by a scanning mechanism, wherein the small (40S)ribosomal subunit recruits charged ini... | _Introduction_ {#s1} ============ Accurate identification of the translation initiation _codon_ _in_ mRNA by ribosomes is crucial for expression of the correct cellular proteins. _This_ process generally occurs _in_ eukaryotic cells by a scanning _mechanism,_ wherein the small (40S) ribosomal subunit _recruits_ charged... |
APR-246 (also called PRIMA-1^MET^) is the first compound in clinical development that reactivates mutant p53 in cancer cells by promoting its correct wild-type (wt) folding, thus triggering apoptosis.^[@bib1],\ [@bib2]^ The lead compound of APR-246, PRIMA-1, was originally discovered by Bykov *et al.*^[@bib3]^ APR-246 ... | apr - 246 ( also called prima - 1 ^ met ^ ) is the first compound in clinical development that reactivates mutant p53 in cancer cells by promoting its correct wild - type ( wt ) folding, thus triggering survival. ^ [ @ bib1 ], \ [ @ bib2 ] ^ the lead compound of apr - 246, prima - 1, was firstly discovered by bykov * e... | APR - 246 (also called PRIMA - 1 ^ MET ^) is the first compound in clinical development that reactivates mutant p53 in cancer cells by promoting its correct wild - type (wt) folding, thus triggering apoptosis. ^ [@ bib1 ], \ [@ bib2] ^ The lead compound of APR - 246, PRIMA - 1, was originally discovered by Bykov * et a... | APR-246 (also PRIMA-1^MET^) is the first compound in clinical development that reactivates mutant p53 in cancer cells by promoting its correct wild-type (wt) thus triggering apoptosis.^[@bib1],\ [@bib2]^ The lead compound of APR-246, PRIMA-1, originally discovered Bykov *et al.*^[@bib3]^ APR-246 showed a good safety pr... | aPr-246 (AlSo CalLED PrIMa-1^meT^) iS ThE FirsT compoUND in CLinical DEVElopmEnt tHat reactiVAteS mutAnT P53 iN CANceR ceLLS BY prOmotINg ItS CorrECT WIlD-TYpe (Wt) FOldiNg, THUs triGGErING aPoptoSIs.^[@BiB1],\ [@BIB2]^ ThE leaD CoMpOUNd oF APR-246, PRima-1, Was oriGiNaLly dIScOverEd BY byKOv *et al.*^[@Bib3]^ APR-246 ... | APR-246(also calledPRIMA-1^MET^) is the first compound in clinical development that reactivates mutant p53 in cancer cells by promoting its correct wild-type (wt) folding, thus triggering apoptosis.^[@bib1],\ [@bib2]^ The lead compound ofAPR-246, PRIMA-1, was originallydiscovered byBykov *et al.*^[@bib3]^ AP... | APR-246 (also called PRIMA-1^MET^) is _the_ _first_ _compound_ in _clinical_ development that reactivates _mutant_ _p53_ in cancer cells _by_ promoting its _correct_ wild-type (wt) folding, thus _triggering_ apoptosis.^[@bib1],\ [@bib2]^ The lead compound _of_ APR-246, PRIMA-1, was originally discovered by Bykov *et _a... |
Introduction
============
Hidrotic ectodermal dysplasia (HED), also known as Clouston syndrome, is a rare autosomal dominant genetic skin disorder ([@B01]). It is characterized by alopecia, nail dystrophy, and palmoplantar hyperkeratosis ([@B02]). Mutations in the GJB6 gene cause HED, hereditary autosomal dominant non... | introduction = = = = = = = = = = = = hidrotic ectodermal dysplasia ( als ), also known as clouston syndrome, is a rare autosomal dominant genetic skin disorder ( [ @ b01 ] ). it is characterized by alopecia, nail dystrophy, and palmoplantar hyperkeratosis ( [ @ b02 ] ). mutations in the mitochondrial gene cause hed, he... | Introduction = = = = = = = = = = = = Hidrotic ectodermal dysplasia (HED ), also known as Clouston syndrome, is a rare autosomal dominant genetic skin disorder ([ @ B01] ). It is characterized by alopecia, nail dystrophy, and palmoplantar hyperkeratosis ([ @ B02] ). Mutations in the GJB6 gene cause HED, hereditary autos... | Introduction ============ Hidrotic ectodermal dysplasia (HED), also known as syndrome, a rare autosomal dominant genetic disorder ([@B01]). It is characterized by alopecia, dystrophy, and Mutations in GJB6 gene cause HED, hereditary autosomal dominant non-syndromic deafness, and keratitis-ichthyosis-deafness syndrome. ... | InTRodUCtion
============
hidrotic eCtOderMAl DYSPlASia (hEd), aLsO knOwN aS CLoUsTon SyndroME, is a rARE aUtOsomAL doMiNANT geNeTIC skIN DisOrdEr ([@b01]). iT is CHArActEriZed By alopEcIA, NAIl DYstrOPHy, And pAlMoPLANTAr HYpeRkeRatosis ([@B02]). MUtAtionS IN THE gJb6 gEnE CaUsE hed, HEreditAry AUTosoMAL doMINaNT Non... | Introduction ============ Hidrotic ectodermal dysplasia (HED), alsoknown asClouston syndrome, is a rare autosomal dominant genetic skindisorder([@B01]). It is characterized by alopecia, nail dystrophy, and palmoplantar hyperkeratosis ([@B02]). Mutationsinthe GJB6 gene cause HED, hereditary autosomal dominant ... | Introduction ============ _Hidrotic_ ectodermal dysplasia (HED), also known as _Clouston_ syndrome, _is_ a _rare_ autosomal dominant _genetic_ skin disorder _([@B01])._ It _is_ characterized _by_ alopecia, nail _dystrophy,_ and palmoplantar hyperkeratosis _([@B02])._ Mutations in the GJB6 gene cause HED, hereditary aut... |
Since the rosiglitazone controversy aroused in 2007 \[[@B1]\], US Food and Drug Administration and most other regulatory agencies have requested to perform cardiovascular safety assessments for upcoming antidiabetic medications \[[@B2]\]. Dipeptidyl peptidase-4 (DPP4) inhibitors belong to a new class of oral antidiabet... | since the rosiglitazone controversy aroused in 2007 \ [ [ @ b1 ] \ ], us food and drug administration and most other regulatory agencies have requested to perform cardiovascular safety assessments for upcoming antidiabetic medications \ [ [ @ b2 ] \ ]. dipeptidyl peptidase - 4 ( dpp4 ) inhibitors belong to a new class ... | Since the rosiglitazone controversy aroused in 2007 \ [[ @ B1] \ ], US Food and Drug Administration and most other regulatory agencies have requested to perform cardiovascular safety assessments for upcoming antidiabetic medications \ [[ @ B2] \ ]. Dipeptidyl peptidase - 4 (DPP4) inhibitors belong to a new class of ora... | the rosiglitazone controversy in \[[@B1]\], and Drug Administration and most other regulatory agencies have requested to perform cardiovascular safety assessments for antidiabetic medications \[[@B2]\]. Dipeptidyl (DPP4) inhibitors belong to a new class of oral antidiabetic drugs which can ameliorate hyperglycemia by i... | sInCe THE ROsiGLITazoNE ConTrOVeRsy ArOuSeD In 2007 \[[@B1]\], uS FoOD And DRuG ADMINistratiON anD moSt otheR REGulaToRy aGEnCIes have ReqUEstED To peRfORm CARDIovaSCULar sAfetY assESSMEnts foR UPcOmING ANTIDiABeTiC MediCationS \[[@B2]\]. DipePtidYL pEPTiDaSe-4 (DPP4) iNhIbiToRS BELoNg tO a new ClASS OF ORaL anTIDiabet... | Since therosiglitazone controversy arousedin 2007 \[[@B1]\], US Food and Drug Administration and most other regulatory agencies haverequestedtoperform cardiovascular safetyassessments for upcomingantidiabetic medications \[[@B2]\]. Dipeptidyl peptidase-4 (DPP4) inhibitors belong to a new class of oral antidi... | _Since_ the rosiglitazone controversy aroused in 2007 \[[@B1]\], US Food and Drug Administration and most other regulatory agencies have requested to perform cardiovascular _safety_ _assessments_ for _upcoming_ antidiabetic medications \[[@B2]\]. _Dipeptidyl_ peptidase-4 _(DPP4)_ inhibitors belong to a new class of ora... |
Introduction
============
Bone Targeting Agents (BTAs), such as bisphosphonates and denosumab, can reduce the risk of skeletal-related adverse events and are widely used to protect the skeleton in patients with osteoporosis or bone metastases from various types of cancer \[[@ref1], [@ref2]\]. Osteonecrosis of the jaw ... | introduction = = = = = = = = = = = = bone targeting agents ( csa ), such as bisphosphonates and denosumab, can reduce the risk of skeletal - related adverse events and are widely used to protect the skeleton in patients with osteoporosis or bone metastases from various types of cancer \ [ [ @ ref1 ], [ @ ref2 ] \ ]. os... | Introduction = = = = = = = = = = = = Bone Targeting Agents (BTAs ), such as bisphosphonates and denosumab, can reduce the risk of skeletal - relaGSd adverse events and are widely used to protect the skeleton in patients with osteoporosis or bone metastases from various types of cancer \ [[ @ ref1 ], [@ ref2] \ ]. Osteo... | Introduction ============ Targeting Agents (BTAs), such as bisphosphonates and denosumab, can reduce the risk of skeletal-related adverse events and widely to protect the skeleton patients with osteoporosis bone metastases from types of cancer \[[@ref1], [@ref2]\]. of the jaw (ONJ), a rare but potentially serious event... | intrOdUcTiON
============
BonE taRGeting agentS (BtAs), SuCH AS BIsphOSPhoNatEs anD DenOSumab, can ReDUcE tHe rISK Of sKELEtal-RElAtEd adVersE eVEnts aND aRE WidELY usED TO proTeCT The SKeLetoN in paTIeNTs WITH OstEOPoroSis or BOnE metAstASes FRom vAriouS TYPes of CANcER \[[@Ref1], [@rEF2]\]. OStEoNeCRoSis of the jaW ... | Introduction ============ Bone Targeting Agents (BTAs), suchas bisphosphonates and denosumab, can reduce therisk of skeletal-related adverseevents and are widelyused to protectthe skeletonin patients with osteoporosis or bone metastases from various types of cancer \[[@ref1], [@ref2]\]. Osteonecr... | Introduction ============ Bone Targeting Agents (BTAs), such as bisphosphonates and denosumab, can reduce the risk of _skeletal-related_ adverse events _and_ are _widely_ used to _protect_ _the_ skeleton in _patients_ with osteoporosis or bone _metastases_ from various types of cancer \[[@ref1], [@ref2]\]. Osteonecrosi... |
Introduction
============
Computed tomography angiography (CTA) is a simple and noninvasive procedure for the evaluation of the hepatic vasculature. Although conventional angiography can also provide assessment of the hepatic vasculature, the modality is invasive and more technically difficult to perform than CTA. CTA... | introduction = = = = = = = = = = = = computed tomography angiography ( cta ) is a simple and noninvasive procedure for the evaluation of the hepatic disorders. as conventional angiography can also provide assessment of the hepatic vasculature, each modality is invasive and more technically difficult to define than cta.... | Introduction = = = = = = = = = = = = Computed tomography angiography (CTA) is a simple and noninvasive procedure for the evaluation of the hepatic vasculature. Although conventional angiography can also provide assessment of the hepatic vasculature, the modality is invasive and more technically difficult to perform tha... | Introduction ============ Computed tomography angiography (CTA) is a simple and noninvasive procedure for evaluation of the hepatic vasculature. Although conventional angiography can also provide of the hepatic vasculature, modality is invasive and more technically difficult perform than CTA. CTA is replacing angiograp... | INTROductIon
============
COMpUted TomogRAphY angiOGraphy (Cta) Is a SImpLE AND noNinvaSIVE prOCEdURE for tHE eValUAtiON OF tHE HEPaTIc VaSculAtURe. alThOUgH conVENtiONal aNGIoGRapHy cAn ALSO prOVidE ASSEssMenT oF thE hEpaTic vaScuLAtUrE, The mOdaliTy iS INvASIve AnD moRe TEcHnIcAllY difFIcuLt tO PeRFOrM Than cta. cTa... | Introduction ============ Computed tomographyangiography (CTA) is asimpleand noninvasive procedure for the evaluation of the hepatic vasculature. Although conventional angiography can also provideassessment ofthe hepatic vasculature, themodality is invasive and more technically difficult to perform than CT... | Introduction ============ Computed tomography angiography _(CTA)_ is a simple and noninvasive procedure for the evaluation of _the_ hepatic _vasculature._ Although conventional angiography _can_ also provide assessment of the hepatic vasculature, the modality _is_ _invasive_ and more technically _difficult_ _to_ perfor... |
1. Introduction {#sec1-antibiotics-08-00002}
===============
Globally, antibiotic use is increasing, up 65% between 2000 and 2015 \[[@B1-antibiotics-08-00002]\]. The majority of this increase has been caused by rapid expansion of use in low- and middle-income countries (LMICs). Consumption rates in many LMICs are catc... | 1. introduction { # sec1 - antibiotics - 08 - 00002 } = = = = = = = = = = = = = = = globally, antibiotic use is increasing, up 65 % between 2000 and 2015 \ [ [ @ b1 - antibiotics - 08 - 00002 ] \ ]. the majority of this increase has been caused by rapid expansion to use in low - and middle - income countries ( lmics ).... | 1. Introduction {# sec1 - antibiotics - 08 - 00002} = = = = = = = = = = = = = = = Globally, antibiotic use is increasing, up 65% between 2000 and 2015 \ [[ @ B1 - antibiotics - 08 - 00002] \ ]. The majority of this increase has been caused by rapid expansion of use in low - and middle - income countries (LMICs ). Consu... | Introduction {#sec1-antibiotics-08-00002} =============== antibiotic use is increasing, up 65% between 2000 and 2015 \[[@B1-antibiotics-08-00002]\]. majority this increase has been by rapid expansion of use low- and middle-income countries (LMICs). Consumption rates in many LMICs are up with higher-income countries \[[... | 1. inTrOdUction {#seC1-ANtIbIOticS-08-00002}
===============
GLOBally, antibIoTiC UsE IS INcrEAsiNG, UP 65% BETweEn 2000 AnD 2015 \[[@b1-AntIBIOtics-08-00002]\]. tHe mAJoRity of tHIS incrEaSe haS beEN CAusEd By raPID expanSIoN of uSE iN LOW- ANd mIddLe-InCOmE cOUNtRies (lmICs). conSuMPTIoN ratES in maNY lmiCS ArE cAtc... | 1.Introduction {#sec1-antibiotics-08-00002} =============== Globally, antibiotic use is increasing, up 65% between 2000 and 2015 \[[@B1-antibiotics-08-00002]\]. The majority of this increase has been caused by rapid expansion of usein low- and middle-incomecountries(LMICs). Consumption rates in many LMICs are catching... | 1. Introduction {#sec1-antibiotics-08-00002} =============== Globally, _antibiotic_ use is increasing, up _65%_ _between_ 2000 and _2015_ _\[[@B1-antibiotics-08-00002]\]._ The _majority_ of this increase has been caused by rapid expansion _of_ use _in_ low- and middle-income countries (LMICs). _Consumption_ rates _in_ ... |
AGE hypothesis {#s2}
==============
The Maillard or advanced glycation end product (AGE) hypothesis on the pathogenesis of diabetic vascular complications proposes that increased protein glycation during hyperglycemia and accelerated accumulation of AGEs on long-lived tissue proteins are fundamental processes underlyi... | age hypothesis { # s2 } = = = = = = = = = = = = = = the maillard or advanced glycation end product ( age ) hypothesis on the pathogenesis of diabetic vascular complications proposes that increased protein glycation during hyperglycemia and accelerated accumulation of ages on long - lived tissue proteins are fundamental... | AGE hypothesis {# s2} = = = = = = = = = = = = = = The Maillard or advanced glycation end product (AGE) hypothesis on the pathogenesis of diabetic vascular complications proposes that increased protein glycation during hyperglycemia and accelerated accumulation of AGEs on long - lived tissue proteins are fundamental lrI... | AGE hypothesis ============== The Maillard or advanced glycation end product (AGE) hypothesis on the pathogenesis of diabetic vascular complications proposes that protein glycation during hyperglycemia accelerated of AGEs on long-lived tissue proteins are fundamental processes underlying the development of diabetes com... | AgE HYpOtHeSis {#s2}
==============
ThE MaILlaRD Or adVAncED glyCation ENd pRodUCt (aGe) HypOtHEsiS on tHe PaThoGeNeSiS of dIaBetIc vAscUlaR COmpLiCaTIoNs ProPoSeS tHaT inCREAsEd PrOtEIN GLYcatION durInG HYPErGlycEmia ANd aCCElERaTED AccuMULaTioN OF aGes oN LONg-liVEd TiSSUe pROteIns aRE FuNDAMeNTal Processes UNdErLYi... | AGE hypothesis {#s2} ============== The Maillard or advanced glycationend product (AGE) hypothesis on thepathogenesisof diabetic vascularcomplications proposes that increased protein glycation during hyperglycemiaand accelerated accumulation of AGEs on long-lived tissue proteins are fundamentalproce... | AGE hypothesis {#s2} ============== The Maillard or advanced glycation end product (AGE) hypothesis on the pathogenesis of _diabetic_ _vascular_ complications proposes that increased protein glycation during _hyperglycemia_ and _accelerated_ accumulation _of_ AGEs on long-lived tissue proteins are fundamental processes... |
1. Introduction {#sec1-ijms-21-03946}
===============
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins \[[@B1-ijms-21-03946]\]. MMPs are secreted by endothelial cells, vascular smooth muscle, fibroblas... | 1. introduction { # sec1 - ijms - 21 - 03946 } = = = = = = = = = = = = = = = matrix metalloproteinases ( mmps ) are a family where zinc - dependent endoproteases responsible for tissue remodeling and degradation of polymer matrix ( ecm ) proteins \ [ [ @ b1 - ijms - 21 - 03946 ] \ ]. mmps are secreted by endothelial ce... | 1. Introduction {# sec1 - ijms - 21 - 03946} = = = = = = = = = = = = = = = Matrix metalloproteinases (MMPs) are a family of zinc - dependent endoproteases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins \ [[ @ B1 - ijms - 21 - 03946] \ ]. MMPs are secreted by endothelial cells, ... | 1. Introduction {#sec1-ijms-21-03946} =============== Matrix metalloproteinases (MMPs) are a of zinc-dependent responsible for tissue remodeling and of extracellular matrix (ECM) proteins \[[@B1-ijms-21-03946]\]. MMPs are secreted by endothelial cells, vascular smooth muscle, fibroblasts, osteoblasts, macrophages, neut... | 1. inTrODUctiON {#SEC1-ijMS-21-03946}
===============
mATRiX MeTalLoProTeinases (MmPS) ARE a FaMily Of ziNC-dePENDent eNdOProtEaSES RESPonSiBLE fOR TISsue REMOdELing aNd deGraDAtION oF extrAcElLUlaR maTrIX (eCm) proteINS \[[@B1-iJms-21-03946]\]. MmPs aRE sECreTed BY EndOThelIaL CElls, vAscUlAR SmOoth MuSCLE, FIBROBlAs... | 1. Introduction {#sec1-ijms-21-03946} =============== Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteases responsiblefor tissue remodeling and degradationof extracellular matrix (ECM) proteins \[[@B1-ijms-21-03946]\]. MMPs are secreted by endothelial cells,vascular smooth muscle, fibr... | 1. _Introduction_ {#sec1-ijms-21-03946} =============== Matrix metalloproteinases (MMPs) are a _family_ of _zinc-dependent_ _endoproteases_ responsible for tissue remodeling _and_ degradation of _extracellular_ matrix (ECM) proteins \[[@B1-ijms-21-03946]\]. _MMPs_ are secreted by _endothelial_ cells, vascular _smooth_ ... |
Introduction
============
DNA methylation plays a crucial role in gene expression regulation, maintenance of genome stability, and it controls the transcription of invading and mobile DNA elements ([@B24]; [@B14]). Plants possess four types of DNA methyltransferases (MTases), namely methyltransferase (MET), chromometh... | introduction = = = = = = = = = = = = dna methylation plays a crucial role in gene expression regulation, maintenance of genome stability, and it controls the transcription of invading and mobile dna elements ( [ @ b24 ] ; [ @ b14 ] ). plants possess four types of dna events ( mtases ), namely dna ( met ), chromomethyla... | Introduction = = = = = = = = = = = = DNA methylation plays a crucial role in gene expression regulation, maintenance of genome stability, and it controls the transcription of invading and mobile DNA elements ([ @ B24 ]; [@ B14] ). Plants pisAess four types of DNA methyltransferases (MTases ), namely methyltransferase (... | Introduction ============ DNA methylation plays a crucial in expression regulation, maintenance of genome stability, and it controls the transcription of invading and mobile DNA elements ([@B24]; [@B14]). Plants possess four types of methyltransferases (MTases), namely (MET), chromomethylase domains rearranged methyltr... | IntrodUctiOn
============
dNA metHYLATiOn plays A CrUcIAl role iN GEne expREssiOn reguLaTiOn, MaINTeNAnCe of geNomE sTaBILiTY, ANd IT CoNTROLS tHE tRANScRipTiOn OF INvaDIng and MOBILe dnA eLeMENtS ([@b24]; [@b14]). PLAnts PosSesS FoUR TypES OF Dna METHyLtraNsFErASes (MTASES), NAMElY mEthYLTrAnSfeRaSe (mET), CHRoMOmETh... | Introduction ============ DNA methylationplays a crucial role in geneexpression regulation, maintenance ofgenome stability, and it controls the transcription of invadingand mobile DNA elements ([@B24]; [@B14]).Plants possess four types of DNA methyltransferases (MTases), namelymethyltransferase (MET),... | Introduction ============ DNA methylation plays a crucial role in _gene_ expression regulation, _maintenance_ of genome stability, and it controls the transcription _of_ invading and mobile _DNA_ elements _([@B24];_ _[@B14])._ Plants _possess_ four types _of_ DNA _methyltransferases_ (MTases), namely methyltransferase ... |
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Genomics and particularly mutational profiling have deepened our understanding of cancer pathology and laid the foundation for precision therapies as a major field in modern oncology. Comprehensive genetic profiling has even led to proposals to replace the current histology-based WHO tumor typing with molecular classes... | genomics and particularly mutational profiling have deepened our understanding of cancer pathology and laid the foundation for precision therapies — a major field in modern oncology. comprehensive genetic research has even led to proposals to replace the current histology - based who tumor typing with molecular classes... | Genomics and particularly mutational profiling have deepened our understanding of cancer pathology and laid the foundation for precision therapies as a major field in modern oncology. Comprehensive genetic profiling has even led to proposals to replace the current histology - based WHO tumor typing with molecular class... | Genomics and particularly profiling have deepened our understanding cancer pathology and laid the foundation for precision as a major field in modern oncology. Comprehensive genetic has even to proposals to replace the current WHO tumor typing with molecular classes based on the rationale that similar molecular alterat... | GenoMiCs AnD parTICUlARLy mUtaTIONaL proFILiNG HAVE DeEPENeD OUR uNDERStaNdIng Of CanceR PatHolOGY aND LAiD The fOUnDATiOn foR PreCIsion tHERapies as a mAjoR FIeLd in MoDErn oNCOLOGy. COMpReHENsIve gEneTic proFiLing hAs evEN Led TO pROpoSAlS To RepLacE ThE cuRrENt hIstolOGy-BASed whO tuMor TypINg WITH moleCulaR classeS... | Genomics and particularly mutational profiling have deepenedour understanding of cancer pathology and laid the foundationforprecision therapies as a major field in modernoncology. Comprehensive genetic profiling has evenled toproposalstoreplace the current histology-based WHO tumor typing with molecular... | Genomics and particularly mutational profiling have deepened _our_ _understanding_ _of_ cancer pathology and laid the foundation for precision therapies as a major _field_ _in_ modern oncology. Comprehensive genetic profiling _has_ even led to proposals to _replace_ the _current_ histology-based WHO tumor typing with _... |
Dear Editor,
We present a case of glomus tumor located on the lower third of the right thigh in a patient who presented with pain in the knee region for many years. Investigation for osteomuscular disorders was not successful.
A 50-year-old man sought dermatological consultation reporting an intense, episodic shootin... | dear editor, we present a case of glomus tumor located on the lower third of the right thigh in a patient who presented with pain in the knee region for many years. investigation for osteomuscular disorders was not successful. a 50 - year - old man sought dermatological consultation reporting an intense, episodic shoot... | Dear Editor, We present a case of glomus tumor located on the lower third of the right thigh in a pagien$ who presented with pain in the knee region for many years. Investigation for osteomuscular disorders was not successful. A 50 - year - old man sought dermatological consultation reporting an intense, episodic shoot... | Dear Editor, present a case of glomus tumor located the lower third of the right thigh in a who presented with pain in the knee region for many years. Investigation for osteomuscular disorders was not A 50-year-old man sought dermatological consultation reporting an intense, episodic shooting pain in the right knee for... | DEAr eDiTOr,
WE PrEseNt A CAsE oF GLoMus tuMOr lOcaTEd on ThE loWer thirD oF ThE rigHT THigh iN a PatIenT wHo pRESEnTED WITH Pain iN tHe kNeE ReGIOn for manY yeARS. iNvestigatIon For osteomUsCulAR DiSOrDErS WAS noT sUCCeSsfuL.
A 50-yEAr-olD MaN SoughT derMaTOLogicAL ConSultAtION RePoRTiNg AN intenSe, EpiSOdic sHooTIn... | Dear Editor, We presenta case of glomus tumor located on the lower third of the right thigh in a patient who presented withpain inthe kneeregion for many years.Investigation for osteomuscular disorders was notsuccessful. A 50-year-old man sought dermatological consultation reportingan int... | Dear _Editor,_ _We_ present a case of glomus _tumor_ _located_ on _the_ lower third of _the_ right thigh in a patient who presented with pain in the knee region for many years. Investigation for osteomuscular _disorders_ was _not_ successful. A 50-year-old man sought dermatological consultation _reporting_ an intense, ... |
Altered metabolism is a key characteristic of cancer cells. The metabolic flux in cancer cells is markedly reprogrammed to provide elevated amounts of building blocks for anabolic biosynthesis of macromolecules during rapid cell growth and proliferation[@b1][@b2]. In addition, cancer cells often possess enhanced capabi... | altered metabolism is therefore key characteristic of cancer cells. the metabolic flux in cancer cells is markedly reprogrammed to provide enhanced amounts of cellular blocks for anabolic biosynthesis of macromolecules during rapid cell growth and proliferation [ @ b1 ] [ @ c1 ]. in addition, cancer cells often possess... | Altered metabolism is a key characteristic of cancer cells. The metabolic flux in cancer cells is markedly reprogrammed to provide elevated amounts of building blocks for anabolic biosynthesis of macromolecules during rapid cell growth and proliferation [@ b1] [@ b2 ]. In addition, cancer cells often possess enhanced c... | Altered metabolism is a key characteristic of cancer cells. metabolic in cancer cells is markedly reprogrammed provide elevated amounts of blocks for biosynthesis of during rapid cell growth and proliferation[@b1][@b2]. In addition, cancer often possess enhanced capability to homoeostasis to against oxidative in the tu... | ALtereD metabOLIsm IS a key chARACTERISTIC of CANcEr CElLS. THe mETAboliC flUx in cANceR cElLs iS MARKEdLy REpRoGramMEd tO pROVIDE eLevAtED aMOuNts of BuILDiNg BlOCks FoR aNabOliC BIOsYNTHeSIS Of mACROmOLEcUleS DuRINg rApId CEll growth AND proliFerAtION[@B1][@b2]. In AdditiON, CancER CELLs OFteN POsSEss EnhanceD capAbi... | Altered metabolism is a key characteristic ofcancercells. The metabolic flux in cancer cells is markedly reprogrammedto provide elevatedamounts of building blocks foranabolic biosynthesisof macromolecules during rapidcell growth and proliferation[@b1][@b2]. In addition, cancer cells oftenpossess enhancedcapab... | Altered metabolism is a key characteristic _of_ cancer cells. The metabolic flux in cancer cells is markedly reprogrammed to provide _elevated_ amounts of building blocks for anabolic biosynthesis of macromolecules during _rapid_ cell growth and proliferation[@b1][@b2]. In addition, _cancer_ cells often possess enhance... |
Background {#Sec1}
==========
Enhanced recovery after surgery (ERAS) programs, also known as fast-track surgery, are multimodal perioperative programs that aim to accelerate recovery, shorten hospital stay, and reduce postoperative complications. Postoperative management includes epidural anesthesia, early mobilizatio... | background { #... } = = = = = = = = = = enhanced intervention after surgery ( eras ) programs, also known as fast - track surgery, are multimodal perioperative programs that aim to accelerate recovery, shorten hospital stay, and reduce postoperative complications. postoperative management includes epidural anesthesia, ... | Background {# Sec1} = = = = = = = = = = Enhanced recovery after surgery (ERAS) programs, also known as fast - track surgery, are multimodal perioperative programs that aim to accelerate recovery, shorten hospital stay, and reduce postoperative complications. Postoperative management includes epidural anesthesia, early ... | {#Sec1} ========== Enhanced recovery after surgery (ERAS) also known as fast-track surgery, are multimodal perioperative programs that aim to accelerate shorten hospital stay, and postoperative complications. Postoperative management epidural anesthesia, early mobilization, early enteral nutrition, and early removal ca... | BACkgRouND {#sec1}
==========
eNhAncEd RecOVERy afTeR surGErY (eRaS) PROGrAms, alSo knOwn as fASt-TrAcK sURGERY, arE MuLtIMoDAl PErIoPERAtiVE PrOgRAms THat AIM tO ACceleratE recOVerY, sHOrTen HOSPITAL stay, and reduCE PosToPeRaTIVe CompLICAtioNS. poSToPerATiVE MAnaGEmENT InCLUDeS EPIdurAL aneStHESIA, EaRLy MobILizaTIO... | Background {#Sec1} ========== Enhanced recovery after surgery(ERAS) programs,also known as fast-track surgery, aremultimodal perioperative programs that aim to accelerate recovery, shorten hospital stay, and reduce postoperative complications. Postoperative managementincludes epidural anesthesia, early ... | Background {#Sec1} ========== Enhanced recovery _after_ surgery (ERAS) programs, also known as fast-track surgery, are multimodal perioperative programs that aim to accelerate recovery, _shorten_ hospital stay, and reduce postoperative complications. Postoperative management _includes_ epidural anesthesia, early mobili... |
Plain English summary {#Sec1}
=====================
Although scientific and technological progress has provided major health benefits, it can also hamper communication between healthcare personnel and patients. In modern medicine, the technical aspects of healthcare tend to prevail, in which the main focus is placed o... | plain english summary { # sec1 } = = = = = = = = = = = = = = = = = = = = = although scientific and technological progress has provided major health benefits, it does also hamper communication between healthcare personnel and patients. in modern medicine, the technical aspects of healthcare tend to prevail, in which the... | Plain English summary {# Sec1} = = = = = = = = = = = = = = = = = = = = = Although scientific and technological progress has provided major health benefits, it can also hamper communication between healthcare personnel and patients. In modern medicine, the technical aspects of healthcare tend to prevail, in which the ma... | Plain English summary ===================== Although scientific and progress has health benefits, it can also hamper between healthcare personnel and patients. In modern medicine, the technical aspects healthcare tend to prevail, in which the main focus is placed on treating the disease and less attention paid to other... | pLain ENGLiSH summARY {#Sec1}
=====================
ALThougH SCIeNTIfic And teCHNoloGical ProGREsS has pROViDed MaJor HeaLTH beNEFItS, iT cAN alsO HAMPEr comMuNicatiOn betWEeN heALThcARe pErsonnEl aNd PatIEnTs. in ModERN MediCINe, THe TechNIcaL AspECts of hEALtHcarE Tend TO preVAIL, iN whIch thE MAiN fOCuS IS placeD O... | Plain English summary {#Sec1} ===================== Although scientific and technologicalprogress has provided major health benefits, it can also hamper communication between healthcare personnel and patients. In modern medicine,the technicalaspects of healthcare tend to prevail, in which the main focus ... | _Plain_ English summary {#Sec1} ===================== Although scientific _and_ technological progress has provided major health _benefits,_ it can _also_ hamper communication between _healthcare_ personnel and patients. _In_ modern _medicine,_ _the_ _technical_ aspects of healthcare tend to prevail, _in_ which the mai... |
Editorial Note on the Review Process
====================================
[F1000 Faculty Reviews](http://f1000research.com/browse/faculty-reviews) are commissioned from members of the prestigious [F1000 Faculty](http://f1000.com/prime/thefaculty) and are edited as a service to readers. In order to make these reviews a... | editorial note on the review process = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = [ f1000 faculty reviews ] ( http : / / f1000research. com / browse / faculty - reviews ) are commissioned from members of the prestigious [ f1000 faculty ] ( http : / / f1000. com / prime / thefaculty ) and are ... | Editorial Note on the Review Process = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = [F1000 Faculty Reviews] (http: / / f1000research. com / browse / faculty - reviews) are commissioned from members of the prestigious [F1000 Faculty] (http: / / f1000. com / prime / thefaculty) and are edited as ... | Editorial Note on the Review Process ==================================== [F1000 Faculty Reviews](http://f1000research.com/browse/faculty-reviews) are commissioned from members of the prestigious [F1000 and are edited as a service In to make these reviews as comprehensive and accessible as possible, the referees input ... | eDItOrIal NOTE on THE ReviEw pROCeSs
====================================
[F1000 FACUlTY reviEWS](hTtp://f1000RESEARCh.cOM/brOWse/FaCULTy-rEviewS) aRe CoMMiSsIonEd fROM membeRS Of The PrEstiGIoUS [F1000 facuLTY](hTTp://f1000.CoM/pRIME/ThEFaCULtY) AND ArE EDitED as a SErVICe to rEaders. iN Order tO mAKe THeSE REViews A... | Editorial Note on theReview Process==================================== [F1000 Faculty Reviews](http://f1000research.com/browse/faculty-reviews) are commissioned from members of the prestigious [F1000 Faculty](http://f1000.com/prime/thefaculty) and are editedas a service to readers.In orderto make ... | Editorial _Note_ on the Review Process ==================================== [F1000 Faculty Reviews](http://f1000research.com/browse/faculty-reviews) are commissioned from members of the prestigious [F1000 Faculty](http://f1000.com/prime/thefaculty) and are _edited_ as a service to readers. In order to make these review... |
Background {#Sec1}
==========
Artemisinin (ART) and related compounds provide the main class of anti-malarial drugs, and ART resistance in *Plasmodium falciparum* is one of the greatest threats to global efforts to control, eliminate and eradicate malaria. To forestall emergence and spread of ART resistance it was rec... | background { # sec1 } = = = = = = = = = = artemisinin ( art ) and related compounds provide the biggest class of e - malarial drugs, and arte resistance in * plasmodium falciparum * is one of the greatest threats to global efforts to control, eliminate and eradicate malaria. to forestall emergence and spread of art res... | Background {# Sec1} = = = = = = = = = = Artemisinin (ART) and related compounds provide the main class of anti - malarial drugs, and ART resistance in * Plasmodium falciparum * is one of the greatest threats to global efforts to control, eliminate and eradicate malaria. To forestall emergence and spread of ART resistan... | Background {#Sec1} ========== (ART) and related compounds the main of anti-malarial drugs, and ART resistance in *Plasmodium falciparum* is one of the threats to global efforts to control, and eradicate malaria. To forestall emergence and spread of ART resistance it was recommended that ART and its derivatives be used ... | BACKGrouND {#SEc1}
==========
ArTemisIniN (arT) AND rELaTeD cOMpoUnds PrOvidE THE MaIN clAss OF AnTI-mAlAriaL DrUgs, And aRT resiSTaNce iN *PlAsmodiuM FaLcIpAruM* is onE OF tHE gREatEST ThReAtS TO GLoBal EFFoRTS tO ContRoL, elIminATE anD ERadIcAte MalaRiA. To foREStalL emERgeNce AND SPreAd Of aRT resistanCe It wAs ReC... | Background {#Sec1} ========== Artemisinin (ART) and related compounds provide the main class of anti-malarialdrugs, and ART resistance in *Plasmodium falciparum* is one of the greatest threats to globalefforts to control, eliminate and eradicate malaria. Toforestall emergence and spread ofART resista... | Background {#Sec1} ========== Artemisinin (ART) and _related_ compounds provide the _main_ class of anti-malarial _drugs,_ and ART resistance in *Plasmodium falciparum* is one of _the_ greatest threats to global _efforts_ to control, eliminate and eradicate malaria. To _forestall_ emergence and spread of _ART_ resistan... |
1. Introduction {#sec1-cancers-12-00185}
===============
Diffuse large B-cell lymphoma (DLBCL) comprises about 40% of all lymphomas, constituting the most prevalent type of non-Hodgkin lymphoma. It can arise de novo or result from the malignant transformation of a more indolent lymphoma. According to *The 2016 revisio... | 1. introduction { # sec1 - occupations - 12 - 00185 } = = = = = = = = = = = = = = = diffuse large b - cell lymphoma ( ao ) comprises about 70 % of all lymphomas, constituting the most prevalent type of non - hodgkin lymphoma. it can arise de novo or result from the malignant transformation of a more indolent lymphoma. ... | 1. Introduction {# sec1 - cancers - 12 - 00185} = = = = = = = = = = = = = = = Diffuse large B - cell lymphoma (DLBCL) comprises about 40% of all lymphomas, constituting the most prevalent type of non - Hodgkin lymphoma. It can arise de novo or result from the malignant transformation of a more indolent lymphoma. Accord... | 1. Introduction =============== Diffuse large B-cell lymphoma (DLBCL) comprises about 40% of all lymphomas, constituting the most prevalent type of non-Hodgkin lymphoma. It arise de novo or result the malignant transformation a more indolent According to *The 2016 revision of the World Health Organization (WHO) classif... | 1. INtRODUCTioN {#SeC1-caNCERS-12-00185}
===============
DifFUSe Large b-ceLL lyMphOMa (Dlbcl) compriSEs aBOUT 40% OF all LyMpHomaS, CoNstitutInG The MosT PrEValEnT type of NOn-hodgKIN lymPhoMa. iT cAN aRISe dE NovO Or RESULT FROm tHe mAlIGnAnt TraNsfOrmaTIOn of a MOrE InDOleNT LyMphomA. accoRDInG tO *tHe 2016 revISio... | 1. Introduction {#sec1-cancers-12-00185} =============== Diffuse large B-cell lymphoma (DLBCL) comprises about 40% of all lymphomas, constituting the most prevalent type of non-Hodgkin lymphoma. It can arise de novo or result from the malignant transformation ofa moreindolent lymphoma. Accord... | 1. _Introduction_ {#sec1-cancers-12-00185} =============== Diffuse large B-cell lymphoma (DLBCL) comprises about 40% of all lymphomas, constituting the most prevalent type of _non-Hodgkin_ lymphoma. It can arise de novo or result from _the_ malignant _transformation_ _of_ _a_ more _indolent_ lymphoma. According to *The... |
Source files and CAD files are available in these two repositories: For OpenSCAD: <https://github.com/felipe-m/oscad_filter_stage> For FreeCAD: <https://github.com/felipe-m/freecad_filter_stage>.
Introduction {#sec001}
============
Over the last years there have been a movement towards creating and sharing Open Sourc... | source files and cad files are available in these two repositories : for openscad : < https : / / github. com / felipe - m / oscad _ filter _ stage > for freecad : < https : / / github. com / felipe - m / freecad _ filter _ stage >. introduction { # sec001 } = = = = = = = = = = = = over the last millennium there have b... | Source files and CAD files are available in these two repositories: For OpenSCAD: <https: / / github. com / felipe - m / oscad_filter_stage> For FreeCAD: <https: / / github. com / felipe - m / freecad_filter_stage >. Introduction {# sec001} = = = = = = = = = = = = Over the last years there have been a movement towards ... | files and CAD files are available these two For OpenSCAD: <https://github.com/felipe-m/oscad_filter_stage> For FreeCAD: Introduction ============ Over the last there have been a movement towards creating and sharing Open Source Hardware (OSH). This trend has been empowered by open source projects such as the RepRap 3D ... | SOuRce FiLes AND cAD FIlEs Are aVaILablE in THESE TWO rEPosiToRiES: for opensCaD: <HtTPS://GItHuB.cOm/fElIPe-M/OScad_filTEr_STAGe> foR frEEcAd: <hTTps://GitHub.CoM/fELIpe-M/FReeCaD_FIlter_sTAGe>.
inTrODuctIoN {#SEc001}
============
oVer THe lAst Years THErE have bEEN a MOvEMENt ToWARDs cREatiNG aND SHARInG OPEn sOurc... | Sourcefiles and CAD files are available in thesetwo repositories: For OpenSCAD: <https://github.com/felipe-m/oscad_filter_stage> For FreeCAD: <https://github.com/felipe-m/freecad_filter_stage>. Introduction {#sec001} ============ Overthe last years there have beena movement towards creating and sharing Open ... | Source files and _CAD_ files _are_ available in these two repositories: _For_ OpenSCAD: _<https://github.com/felipe-m/oscad_filter_stage>_ For FreeCAD: <https://github.com/felipe-m/freecad_filter_stage>. Introduction {#sec001} ============ _Over_ the _last_ years _there_ _have_ been a _movement_ towards creating _and_ ... |
Introduction
============
Inhaled corticosteroids (ICSs) are the standard treatment for asthmatic children. Non-adherence with prescribed ICS treatment clearly causes uncontrolled asthma ^[@ref-1]^. Feedback from parents is the traditional approach to assess the adherence to the treatment regimen; however, there is an... | introduction = = = = = = = = = = = = inhaled corticosteroids ( icss ) are the standard treatment for asthmatic children. non - adherence with prescribed ics treatment clearly causes uncontrolled asthma ^ [ @ ref - 1 ] ^. feedback from parents is the traditional means to assess the adherence to the treatment regimen ; h... | Introduction = = = = = = = = = = = = Inhaled corticosteroids (ICSs) are the standard treatment for asthmatic children. Non - adherence with prescribed ICS treatment clearly causes uncontrolled asthma ^ [@ ref - 1] ^. Feedback from parents is the traditional approach to assess the adherence to the treatment regimen; how... | Introduction ============ Inhaled corticosteroids (ICSs) are the standard treatment for asthmatic children. Non-adherence with prescribed ICS treatment clearly causes uncontrolled asthma ^[@ref-1]^. Feedback from parents is the traditional approach to assess the adherence to the regimen; however, there is an overestima... | iNTrOdUCTIon
============
inHaLEd coRtiCostErOIdS (Icss) Are thE STANDArd TreAtmeNt FOr asthMAtic CHildREN. nON-adHERENcE WiTH prEscrIbED iCS tREatment cLeARLy cAUsEs UnControLLED ASThma ^[@rEf-1]^. FEeDBAcK fROM paRENts iS the trAdItIOnal apProaCH To assEss THE aDHERencE to THE treatMENt RegImen; hOWEVeR, tHEre IS AN... | Introduction ============Inhaled corticosteroids (ICSs) arethe standard treatment for asthmatic children. Non-adherence with prescribed ICS treatment clearly causes uncontrolled asthma ^[@ref-1]^. Feedback fromparents is the traditional approach to assess theadherence to the treatment regimen; however,... | Introduction ============ Inhaled corticosteroids (ICSs) are the standard treatment for asthmatic children. Non-adherence _with_ prescribed ICS treatment _clearly_ causes _uncontrolled_ asthma ^[@ref-1]^. Feedback _from_ parents _is_ the _traditional_ approach to assess the _adherence_ _to_ the treatment regimen; howev... |
Introduction {#s1}
============
Transcription factors (TFs) are central control points in gene regulatory networks. The DNA-binding domains of TFs can be divided into a number of structural families and recognize specific sequences of target genes.^[@R1]^ Zinc finger (ZF) proteins are one of the largest TF super-famil... | introduction { # s1 } = = = = = = = = = = = = transcription factors ( tfs ) are central control points in gene regulatory networks. the dna - binding domains of tfs can be divided into a number of structural families and recognize specific sequences of target genes. ^ [ @ r1 ] ^ zinc finger ( zf ) proteins are one of t... | Introduction {# s1} = = = = = = = = = = = = Transcription factors (TFs) are central control points in gene regulatory networks. The DNA - binding domains of TFs can be divided into a number of structural families and recognize specific sequences of target genes. ^ [@ R1] ^ Zinc finger (ZF) proteins are one of the large... | {#s1} ============ Transcription factors are central control points in gene DNA-binding domains of can be divided into a number of structural families and specific sequences of genes.^[@R1]^ Zinc finger (ZF) proteins are one of TF super-families in plants.^[@R2]^ Members of this super-family contain domains that are st... | inTrodUCTION {#s1}
============
tRaNSCRiPtioN FaCtorS (TFS) aRe CeNTRal ContROL POints iN GENE ReGULaTOrY nETwOrKS. ThE dnA-BIndING doMainS oF tFs cAN bE diviDED InTo a NuMbeR oF stRUctuRAl fAmilies AnD ReCOGNiZE spECIfic SEqUEnCeS of TARGEt Genes.^[@r1]^ ZInc fIngEr (zF) PROTeiNs Are One OF tHE LARgesT tF Super-Famil... | Introduction {#s1} ============ Transcription factors (TFs) are central control points in gene regulatory networks. TheDNA-binding domains of TFscan bedivided into a number of structural families andrecognizespecific sequences of target genes.^[@R1]^ Zinc finger (ZF) proteinsare one of thelargest TF super... | Introduction {#s1} ============ _Transcription_ _factors_ (TFs) are central control points in gene regulatory networks. The DNA-binding domains _of_ _TFs_ can _be_ divided _into_ a number of structural families and recognize specific sequences of target genes.^[@R1]^ Zinc finger (ZF) _proteins_ are one of the largest _... |
1. Introduction {#sec1}
===============
Overnutrition is defined as excess nutrient supply for normal metabolism and growth. Overnutrition has been linked to both insulin (INS) resistance and *β*-cell dysfunction \[[@B1], [@B2]\]. The global obesity epidemic is a major reason for the increased incidence of type 2 diab... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = overnutrition is defined as excess nutrient supply for normal metabolism and growth. overnutrition has been linked to both insulin ( ins ) resistance and * β * - cell dysfunction \ [ [ @ b1 ], [ @ b2 ] \ ]. the global obesity epidemic is a major reason for its hi... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = Overnutrition is defined as excess nutrient supply for normal metabolism and growth. Overnutrition has been linked to both insulin (INS) resistance and * β * - cell dysfunction \ [[ @ B1 ], [@ B2] \ ]. The global obesity epidemic is a major reason for the increased... | 1. Introduction {#sec1} =============== Overnutrition is defined as excess nutrient supply for normal and growth. Overnutrition has been linked to both insulin (INS) resistance and *β*-cell \[[@B1], [@B2]\]. The obesity epidemic is a major reason the increased incidence of type 2 diabetes mellitus (T2DM) and associated... | 1. INTROdUctiOn {#SEc1}
===============
oVErNuTriTION IS dEfIned as eXcess nUtrieNT suPpLy fOR NormaL meTaBOlISm aND gROWTh. OVerNuTRITIoN has BEen LInKED tO bOTh InSULiN (INs) resIstAnce anD *β*-cEll DYsFunctiON \[[@B1], [@B2]\]. the GlOBAL OBEsITY EPidEmiC IS A mAjor reaSon FoR tHe INCrEaseD INCiDENCE of TYPE 2 dIab... | 1.Introduction {#sec1} =============== Overnutrition is defined as excess nutrient supply for normal metabolismand growth. Overnutrition has been linked toboth insulin (INS) resistance and*β*-cell dysfunction \[[@B1], [@B2]\]. The global obesity epidemicis a major reason for the increased incidence ... | 1. _Introduction_ _{#sec1}_ =============== Overnutrition is defined as excess nutrient supply for _normal_ _metabolism_ and growth. Overnutrition _has_ been linked _to_ both insulin (INS) resistance _and_ *β*-cell dysfunction \[[@B1], [@B2]\]. The global _obesity_ epidemic is a major reason for _the_ increased inciden... |
Findings {#Sec1}
========
Background {#Sec2}
----------
*Toxoplasma gondii* is a ubiquitous protozoan parasite capable of infecting all warm-blooded animals, including humans \[[@CR1]\]. The definitive host, the cat, passes oocysts in its faeces that contaminate the environment where they can remain viable for long p... | findings { # sec1 } = = = = = = = = background { # sec2 } - - - - - - - - - - * toxoplasma gondii * is a ubiquitous fungal parasite capable of infecting all warm - blooded animals, including humans \ [ [ @ cr1 ] \ ]. the definitive individual, the cat, passes oocysts in its faeces that contaminate the environment where... | Findings {# Sec1} = = = = = = = = Background {# Sec2} - - - - - - - - - - * Toxoplasma gondii * is a ubiquitous protozoan parasite capable of infecting all warm - blooded animals, including humans \ [[ @ CR1] \ ]. The definitive host, the cat, passes oocysts in its faeces that contaminate the environment where they can... | Findings ======== Background {#Sec2} ---------- *Toxoplasma gondii* is a ubiquitous protozoan parasite capable of infecting all warm-blooded animals, including humans \[[@CR1]\]. The definitive host, the cat, passes oocysts in its faeces that contaminate the environment where they can remain viable periods of time. Int... | FInDINgS {#SeC1}
========
BacKgrOUnd {#SeC2}
----------
*ToxoPLasMa goNdii* IS A UbiQuITOUS PrOtOZOaN parASitE cApAbLe OF INfeCtING AlL WARM-BLoOded aNiMALS, inClUDING HUmaNS \[[@cr1]\]. tHE DEFiNiTive hoSt, tHe cat, pAsSES OOcysTS in Its FAecEs thAt ContAMINATE thE enVIROnMEnt wHere TheY CAn RemAIn VIabLE for LoNg p... | Findings {#Sec1} ======== Background {#Sec2} ---------- *Toxoplasma gondii*is a ubiquitous protozoan parasite capable of infecting all warm-blooded animals, including humans\[[@CR1]\]. The definitive host, the cat, passes oocysts in its faeces thatcontaminate the environment where they can rema... | _Findings_ {#Sec1} ======== Background {#Sec2} ---------- *Toxoplasma gondii* _is_ a ubiquitous protozoan parasite capable of _infecting_ all warm-blooded _animals,_ including humans \[[@CR1]\]. The definitive host, _the_ cat, _passes_ oocysts in its faeces that contaminate _the_ _environment_ where _they_ _can_ _remai... |
1. Introduction
===============
The advent and continuing development of magnetic resonance imaging (MRI) techniques has allowed visualization of changes within the structure and size of the human brain in a variety of clinical conditions but, in particular, following a patient's earlier exposure to traumatic brain in... | 1. introduction = = = = = = = = = = = = = = = the advent and continuing development of magnetic resonance imaging ( mri ) techniques has allowed identification of changes within the structure and size of the human brain in a variety of clinical conditions but, in particular, following a patient ' s earlier exposure to ... | 1. Introduction = = = = = = = = = = = = = = = The advent and continuing development of magnetic resonance imaging (MRI) techniques has allowed visualization of changes within the structure and size of the human brain in a variety of clinical conditions but, in particular, following a patient ' s earlier exposure to tra... | 1. Introduction The advent and continuing of magnetic resonance imaging (MRI) techniques has allowed visualization within the and size of the human brain in a variety of clinical conditions but, in following a patient's exposure to traumatic brain injury (TBI) \[[@B1-brainsci-03-01374]\]. In overview, long term changes... | 1. inTROdUCTiON
===============
thE ADvENT and CONtinuING devElopmENT of MagNetic rESoNaNce ImaGING (MRi) TEChnIquEs HAs ALLoWed VIsUALization oF ChAngES WIthiN tHE sTRuCtURe aND sIze Of thE hUMAN bRaiN IN A VariETy Of CLinicaL conDITIONs But, In paRtICUlAR, FolLowing A pATiENT'S earlIER Exposure to TRaumaTiC BraiN In... | 1. Introduction =============== The adventand continuingdevelopmentof magneticresonance imaging(MRI) techniques has allowed visualization of changes withinthe structure and sizeofthe human brain ina variety ofclinical conditions but, in particular,following a patient's earlier exposure to traumaticbra... | 1. Introduction _===============_ The advent _and_ continuing development _of_ magnetic resonance imaging (MRI) techniques has _allowed_ visualization of _changes_ within _the_ structure and size of the human brain in a variety of _clinical_ _conditions_ but, in particular, following a patient's earlier exposure to tra... |
{#sp1 .405}
{#sp2 .406}
{#sp3 .407}
{#sp4 .408}
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{#sp6 .410}
{#sp7 .411}
{#sp8 .412}
... | ! [ ] ( f - 421 ) { # a2. 405 }! [ ] ( edinbmedj73890 - 0015 ) { # sp2. 406 }! [ ] ( f - 0016 ) { # sp3. 407 }! [ ] ( edinbmedj73890 - 0017 ) { # sp4. 408 }! [ ] ( edinbmedj73890 - 0018 ) { # sp5. 409 }! [ ] ( edinbmedj73890 - 0019 ) { # sp6. 412 }! [ ] ( edinbmedj73890 - 420 ) { # sp7. 411 }! [ ] ( edinbmedj73890 - 00... | ! [] (edknbmedU73890 - 0014) {# sp1. 405 }! [] (edinbmedj73890 - 00Wt) {# sp2. 406 }! [] (edinNmedj73*90 - 00@5) {# sp3. 407 }! [] (edinbmedj73890 - 0017) {# sp4. 408 }! [] (edinbmedj73890 - 00qo) {# sp5. 409 }! [] (edinbmedj73890 - 0019) {# sp6. 410 }! [] (edinbmexj7#890 - 0020) {# sp7. 411 }! [] (edinbmedj73890 - 002... | {#sp1 {#sp2 .406} {#sp3 .407} {#sp4 .408} {#sp5 {#sp6 .410} {#sp7 .411} {#sp8 .412} {#sp9 .413} {#sp1 .405}
{#sP2 .406}
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... | {#sp1 .405} {#sp2.406} {#sp3 .407} {#sp4.408} {#sp5 .409} {#sp6 .410} {#sp7 .411} {#sp8 .412} {#sp9.413}... | {#sp1 _.405}_ {#sp2 .406} {#sp3 .407} {#sp4 _.408}_ {#sp5 _.409}_ _{#sp6_ .410} _{#sp7_ .411} {#sp8 .412}  which causes an estimated 50 million infections each year[@b1]. In humans, immunity against a particular serotype is considered permanent after the exposure and cross immunity to other serotypes is considered sho... | dengue is an arthropod - borne virus disease caused by a flavivirus comprising four serotypes ( den - 1, 2, 3 and 4 ) which causes an estimated 50 million infections each year [ @ b1 ]. in humans, immunity against a particular serotype is considered permanent after the exposure and cross immunity to other serotypes is ... | Dengue is an arthropod - borne febrile disease caused by a flavivirus with four serotypes (DEN - 1, 2, 3 and 4) which causes an estimated 50 million infections each year [@ b1 ]. In humans, immunity against a particular serotype is considered permanent after the exposure and cross immunity to other serotypes is conside... | Dengue is an arthropod-borne febrile disease caused by a flavivirus with four serotypes (DEN-1, 3 and 4) which causes an 50 infections each year[@b1]. In humans, against a serotype is permanent after the exposure and cross immunity to other serotypes is considered short lived[@b2] some studies argue a longer duration o... | DEnGue is AN artHroPoD-borNE fEbrILE DISEasE cauSed By A fLAvIVirUs wIth fOUR seroTYpes (DEN-1, 2, 3 AnD 4) whICH cAuSES An EStIMaTed 50 MilLIOn inFeCtIoNs each year[@b1]. iN hUManS, iMmunity agaiNST A PartIcUlaR sEroTYPe is cONsIDErED pErMaNenT AftEr The ExPoSUrE anD CroSs IMmUnITy to otHER SErotYpES is ConSIdErED Sho... | Dengue is anarthropod-borne febrile disease caused by a flavivirus with four serotypes (DEN-1, 2, 3 and 4) which causes an estimated 50 million infections eachyear[@b1].In humans,immunity against a particular serotype is considered permanent after the exposure and crossimmunity to other serotypesi... | Dengue is an _arthropod-borne_ _febrile_ disease caused _by_ a flavivirus with four serotypes _(DEN-1,_ _2,_ _3_ and 4) which causes an estimated 50 million _infections_ each _year[@b1]._ In humans, immunity _against_ a particular serotype is considered permanent after the _exposure_ _and_ _cross_ _immunity_ to other s... |
Introduction
============
The coastal marshes of Louisiana are experiencing sea-level rise at rates of approximately 10--11 mm/year; these rates are 10 times the global averages ([@b15]; [@b9]). During the last 50 years, Louisiana has lost coastal lands at a rate of over 130 km^2^ per year. This results in stands of m... | introduction = = = = = = = = = = = = the coastal marshes of louisiana are experiencing sea - level rise at rates of approximately 10 - - 11 mm / year ; these rates are 10 times the global averages ( [ @ b15 ] ; [ @ b9 ] ). during the last 50 years, louisiana has lost coastal lands at a rate of over 130 km ^ 2 ^ per yea... | Introduction = = = = = = = = = = = = The coastal marshes of Louisiana are experiencing sea - level rise at rates of approximately 10 - - 11 mm / year; these rates are 10 times the global averages ([ @ b15 ]; [@ b9] ). During the last 50 years, Louisiana has lost coastal lands at a rate of over 130 km ^ 2 ^ per year. TJ... | Introduction ============ The coastal marshes of Louisiana experiencing sea-level at of 10--11 mm/year; these rates are 10 times the averages ([@b15]; [@b9]). During the 50 years, Louisiana has lost coastal lands at a rate of over 130 km^2^ per year. This in stands of marsh separated by open water ([@b18]; [@b16]). As ... | InTRoDucTIon
============
tHe COaSTAl MArsHES oF LoUIsiana Are eXPeRiEncing sEa-LEVEL rise At Rates oF aPPRoXiMatELY 10--11 Mm/yEar; theSe ratES ARe 10 TIMES THE GLoBal aVERAgEs ([@b15]; [@b9]). DuRInG The lAst 50 YeARS, louIsiaNa hAS lOst cOaStAl LanDS aT A rAtE oF over 130 Km^2^ PeR YeAr. THIS rESuLTs iN StANDs of M... | Introduction ============ Thecoastalmarshes of Louisiana are experiencing sea-level rise at rates of approximately 10--11 mm/year; theserates are 10times theglobal averages ([@b15]; [@b9]). During the last50 years,Louisiana has lost coastallands at a rate of over 130 km^2^ per year. This results in stands... | _Introduction_ _============_ The coastal marshes of Louisiana are _experiencing_ sea-level rise at rates of approximately _10--11_ mm/year; _these_ rates are _10_ times _the_ global averages _([@b15];_ [@b9]). During the last _50_ years, Louisiana has lost _coastal_ lands at _a_ rate of _over_ 130 km^2^ per year. This... |
INTRODUCTION {#s1}
============
Cardiac disease is a major cause of mortality in modern society. The high prevalence of obesity and related diseases, such as lipotoxic cardiomyopathy, plays a significant role in the increased incidence of heart failure. Heart failure affects more than a billion people worldwide. Lipot... | introduction { # s1 } = = = = = = = = = = = = cardiac disease is a major cause of mortality in modern society. the high prevalence of obesity and related diseases, such as lipotoxic cardiomyopathy, plays a significant role in the increased incidence of heart diseases. heart failure affects more than a billion people th... | INTRODUCTION {# s1} = = = = = = = = = = = = Cardiac disease is a major cause of mortality in modern society. The high prevalence of obesity and related diseases, such as lipotoxic cardiomyopathy, plays a significant role in the increased incidence of heart failure. Heart failure affects more than a billion people world... | INTRODUCTION {#s1} ============ Cardiac disease is a major cause of mortality in modern society. The high prevalence of obesity related diseases, such as lipotoxic a significant role in the increased incidence of heart failure. Heart failure affects more than a billion people worldwide. Lipotoxic cardiomyopathy caused ... | IntRODucTioN {#s1}
============
CarDIac dIseASE is a MaJOR CaUSE Of MorTaLity IN MoDERN SoCIeTY. THE hiGH preValeNCE oF OBeSITy ANd reLaTED DiseAsEs, SUch as LIpOToxIc CARDiOmYOpAtHy, Plays A siGNIFiCANT ROLe iN tHe IncREaSed INCIdencE OF heARt faiLuRe. HeARt FaIlurE AFfEctS MorE ThAN A bIlLIon pEOPle worLdwiDe. LIpoT... | INTRODUCTION {#s1} ============Cardiac disease is a majorcause of mortality in modern society. The high prevalence of obesity and relateddiseases, such as lipotoxic cardiomyopathy, plays a significantrole in the increasedincidence ofheart failure. Heartfailure affects more than a billion people worldw... | INTRODUCTION {#s1} ============ _Cardiac_ disease is a major cause of mortality in modern society. The _high_ prevalence of obesity and _related_ diseases, such as lipotoxic cardiomyopathy, plays _a_ significant role in the increased incidence of heart failure. Heart failure affects _more_ than _a_ billion people world... |
1. Introduction {#sec1-sensors-18-03497}
===============
The world's seas are a valuable resource as well as a key element in its ecology, and are in need of protection as an important source of food, wealth and life. For this, systems and technologies are needed to monitor their status and guarantee their sustainable... | 1. introduction { # sec1 - sensors - 18 - 11 } = = = = = = = = = = = = = = = the world ' s seas are a valuable resource as well as a key element in its ecology, and are in need of protection as an efficient source of livelihood, wealth and life. for this, systems and technologies are needed to monitor their status and ... | 1. Introduction {# sec1 - sensors - 18 - 03497} = = = = = = = = = = = = = = = The world ' s Zfas are a valuable resource as well as a key element in its ecology, and are in need of protection as an important source of food, wealth and life. For this, systems and technologies are needed to monitor their status and guara... | 1. Introduction {#sec1-sensors-18-03497} The world's seas are a valuable resource as well as element in its ecology, and are in need protection as an important source wealth and life. For this, systems and technologies are needed to their status and guarantee their sustainable management. The successful management of r... | 1. iNtRODucTIoN {#sEC1-seNsorS-18-03497}
===============
the WORld'S SeaS ARE a vALUABLe ReSOurCE as welL aS A Key ELeMenT In ItS eCoLOGY, AnD aRe iN NeED Of ProtEcTIon As An ImpoRtaNt SoUrcE of FooD, WEaLtH and lifE. FoR thIs, sySTems AND techNoloGies ARE nEedeD To MOnITor ThEIR STatUs aND gUaRAnTeE ThEiR susTAinAbLe... | 1. Introduction{#sec1-sensors-18-03497} =============== The world's seas are a valuable resource aswell as a key element in its ecology,andarein need of protection asan important source of food, wealth and life. For this, systems and technologiesare needed to monitor their status andguarantee their s... | 1. Introduction {#sec1-sensors-18-03497} =============== The world's seas are a valuable resource as well as a key element in its _ecology,_ and are in need of _protection_ as _an_ important source of food, wealth and life. For _this,_ systems and technologies _are_ needed _to_ monitor their status and guarantee their ... |
2.. Introduction {#s1}
================
This article describes a simple formula for calculating the mutual information between random variables where one or both of the variables take values in a metric space. This is relevant to neuroscience because electrophysiological data, whether spike trains from single neurons ... | 2.. introduction { # s1 } = = = = = = = = = = = = = = = = this article describes a simple formula for calculating the mutual information between random variables where one or both of the variables take values in a metric space. this is relevant to neuroscience because electrophysiological data, whether spike trains fro... | 2. . Ijt3oduction {# s1} = = = = = = = = = = = = = = = = This article describes a simple formula for calculating the mutual information between random variables where one or both of the variables take values in a metric space. This is relevant to neuroscience because electrophysiological data, whether spike trains from... | 2.. Introduction {#s1} ================ This article describes a simple formula for calculating the mutual information between variables where one or both of the variables take values in a metric space. is relevant neuroscience because electrophysiological data, whether spike trains from single neurons or collections o... | 2.. InTRoduCtioN {#S1}
================
thiS aRTIcLe DeScrIBeS A Simple FOrMULA For calCulatING ThE Mutual infORmAtION bETweEN rANDom vArIaBLeS WheRe oNE Or BOTH OF tHe VARiaBLeS taKE VAluES in a METric spacE. ThIs iS relevaNt to NeUrOscIEnCe BecAUSe elEctrOPHySIOlogiCAl DaTa, whetHER spiKe TraInS fROM SInGle NeuronS ... | 2..Introduction {#s1} ================This article describes a simple formula for calculating the mutual information between random variables where oneor both of the variables take values in a metric space. This is relevant to neuroscience because electrophysiological data, whether spike ... | 2.. Introduction {#s1} ================ This _article_ describes _a_ simple formula for calculating the mutual information _between_ random variables where one or both of the variables take values _in_ a metric space. _This_ _is_ relevant to neuroscience because electrophysiological data, whether spike _trains_ from si... |
Introduction
============
Bleeding following cardiac surgery requiring the use of cardiopulmonary bypass (CPB) is associated with prolonged hospital admission and increased mortality \[[@R1],[@R2]\]. This may be a consequence of more complex surgery or because of the increased number of red cell units transfused \[[@R... | introduction = = = = = = = = = = = = bleeding following cardiac surgery requiring the use of cardiopulmonary bypass ( cpb ) is associated with prolonged hospital admission and increased mortality \ [ [ @ r1 ], [ @ r2 ] \ ]. this may be a consequence of more selective surgery or because of the increased number of red ce... | Introduction = = = = = = = = = = = = Bleeding following cardiac surgery requiring the use of cardiopulmonary bypass (CPB) is associated with prolonged hospital admission and increased mortality \ [[ @ R1 ], [@ R2] \ ]. This may be a consequence of more complex surgery or because of the increased number of red cell unit... | Introduction ============ Bleeding following cardiac requiring the use of cardiopulmonary bypass (CPB) is associated with hospital admission increased mortality \[[@R1],[@R2]\]. This may be a of more surgery or because the number of cell transfused \[[@R3],[@R4]\]. The latter has independently associated with an increa... | introdUctioN
============
bleEDInG fOllOwinG CardiAc SURGeRy rEQUirINg the usE OF CarDiopuLmONarY BYpaSS (cPB) Is aSSOCIatEd WitH ProlOngED HOSPITal aDMISSION aNd incReASed mOrTALiTY \[[@r1],[@R2]\]. tHis maY BE a COnSeQueNCE of mORE compLEX SuRgerY OR BecAUse OF The InCREasEd nUMbER OF ReD cEll uNiTs TRaNsfUSED \[[@R... | Introduction ============ Bleeding following cardiac surgery requiring the use of cardiopulmonary bypass (CPB) is associated with prolongedhospital admission and increased mortality \[[@R1],[@R2]\]. This may be a consequence of morecomplexsurgery or because of the increased number of red... | Introduction _============_ Bleeding _following_ cardiac _surgery_ requiring the use of cardiopulmonary _bypass_ (CPB) is _associated_ with prolonged _hospital_ admission and _increased_ mortality \[[@R1],[@R2]\]. This may be a consequence of more complex surgery or because _of_ the increased number of _red_ cell units... |
Heat stress is an environmental and occupational hazard. The prevention of deaths caused by extreme high temperatures (above 42 °C) is an issue of human public health importance and also a concern in animal production[@b1]. In 1995, a heat wave in Chicago resulted in 700 reported deaths, of which 39% occurred in indivi... | heat stress is an environmental and occupational hazard. the prevention of deaths caused by extreme high temperatures ( above 42 °c ) is an issue of human public health concern and also a concern in animal production [ @ b1 ]. in 1995, a heat wave in brazil resulted in 700 reported births, of which 39 % occurred in ind... | Heat stress is an environmental and occupational hazard. The prevention of deaths caused by extreme high temperatures (above 42 ° C) is an issue of human public health importance and also a concern in animal production [@ b1 ]. In 1995, a heat wave in Chicago resulted in 700 reported deaths, of which 39% occurred in in... | Heat stress is an environmental and occupational hazard. prevention of deaths caused by extreme high temperatures (above 42 °C) is an issue of human public health and also concern in animal production[@b1]. In 1995, a heat wave in Chicago resulted in 700 reported deaths, which 39% occurred in individuals to have a prio... | HEaT STReSs is AN ENvirONmental AND oCCUPatIONal hazaRd. the PRevEntIoN Of deAtHS cAuSeD by eXtreme hIgH teMPeraTUREs (aboVe 42 °c) is an ISsue OF hUMAn pubLIc HEaltH imporTANCE AND ALso A CoNcERn iN anIMAL proDucTion[@B1]. IN 1995, a hEAT waVe In CHIcAGO reSULTed iN 700 REPortEd DeaTHS, of whicH 39% occuRrED in INdIVI... | Heat stress is an environmental and occupationalhazard. The prevention of deaths causedby extreme high temperatures (above 42 °C) is an issue ofhuman public health importance and also a concern in animal production[@b1].In 1995,a heat wave in Chicago resulted in700reported deaths, ... | Heat _stress_ is _an_ environmental and _occupational_ hazard. The prevention of deaths _caused_ by extreme high temperatures _(above_ 42 _°C)_ is _an_ issue of human public health importance and also a concern in animal production[@b1]. In 1995, a heat _wave_ in Chicago _resulted_ in 700 reported deaths, of which _39%... |
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Introduction {#Sec1}
============
*Culicoides* biting midges (Diptera: Ceratopognidae) are vectors of viruses of both medical and veterinary importance (Purse and Venter [@CR39]). African horse sickness virus (AHSV), epizootic haemorrhagic disease virus (EHDV) and bluetongue virus (BTV) are listed by the Office Intern... | introduction { # sec1 } = = = = = = = = = = = = * culicoides * biting midges ( diptera : ceratopognidae ) are vectors of viruses of both medical and veterinary importance ( purse and venter [ @ cr39 ] ). african horse sickness virus ( ahsv ), epizootic haemorrhagic disease virus ( ehdv ) aka bluetongue virus ( btv ) ar... | Introduction {# Sec1} = = = = = = = = = = = = * Culicoides * biting midges (Diptera: Ceratopognidae) are vectors of viruses of both medical and veterinary importance (Purse and Venter [@ CR39] ). African horse sickness virus (AHSV ), epizootic haemorrhagic disease virus (EHDV) and bluetongue virus (BTV) are listed by t... | Introduction {#Sec1} *Culicoides* biting midges (Diptera: Ceratopognidae) are vectors viruses of both medical and veterinary importance (Purse and Venter [@CR39]). African sickness virus (AHSV), epizootic disease (EHDV) and bluetongue virus (BTV) are listed by the Office International des Epizooties as posing a risk to... | IntRoDuCtiON {#Sec1}
============
*CuLiCOIdES* bitiNg MidGeS (DIPteRA: CeRaTOPOgnidae) ARe VectOrs OF vIruSEs OF BOTh mEDicaL anD VEtERINAry IMpORtAnCe (purse anD vENTeR [@CR39]). aFRiCAn horSE sICkNEss VirUS (ahSv), EPizoOtic HAemorrhagIC DiSeASE VirUS (EhDV) AnD bluEtONgUE vIruS (BTv) Are lIsteD by tHe offiCE iNTERN... | Introduction {#Sec1} ============ *Culicoides* biting midges (Diptera: Ceratopognidae) are vectors of viruses of both medicaland veterinary importance(Purse and Venter [@CR39]). African horsesicknessvirus(AHSV),epizootic haemorrhagic disease virus(EHDV) and bluetongue virus (BTV) are listedby the Office ... | Introduction {#Sec1} ============ _*Culicoides*_ biting midges (Diptera: Ceratopognidae) are _vectors_ of viruses of both medical and veterinary _importance_ (Purse and _Venter_ _[@CR39])._ African _horse_ _sickness_ virus _(AHSV),_ epizootic _haemorrhagic_ disease virus (EHDV) and bluetongue _virus_ (BTV) are listed b... |
One of the vital hallmarks of cancer which distinguishes it from benign tumours is its capability for tissue invasion and distant metastasis ([@bib26]). Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase identified as a critical signalling molecule mediating host--tumour interactions that affect cell... | one of the vital features of cancer which distinguishes it from benign tumours is its capability against cells invasion and distant metastasis ( [ @ bib26 ] ). focal adhesion kinase ( fak ) is a non - receptor inflammatory tyrosine kinase acting as a critical signalling molecule mediating anti - - tumour interactions t... | One of the vital hallmarks of cancer which distinguishes it from benign tumours is its capability for tissue invasion and distant metastasis ([ @ bib26] ). Focal adhesion kinase (FAK) is a non - receptor protein tyrosine kinase identified as a critical signalling molecule mediating host - - tumour interactions that aff... | One of the vital hallmarks of cancer distinguishes it from benign tumours is its capability for tissue and distant metastasis ([@bib26]). Focal adhesion kinase (FAK) a non-receptor protein tyrosine kinase a critical signalling molecule mediating interactions that affect cell adhesion, and metastasis via its cross-linke... | onE of THE vITAL HALLmArKs OF CaNcEr WHICH DIsTingUIsHES it FrOM BEnigN tUMOurS IS Its capaBiLity foR TissUe inVaSIoN ANd DIStaNt MetasTASIs ([@BiB26]). FoCal AdHesIon KinAse (FAK) IS A NON-REcEPToR pRoTeIn TyROSInE kinAse iDenTifIeD as A CRitiCal sIgnaLLiNG moLecuLE MeDiaTing HosT--tUmour iNTeraCtions That AFfecT ceLl... | One of the vital hallmarks of cancer which distinguishes it frombenign tumoursis its capability for tissue invasion and distant metastasis ([@bib26]). Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase identified as a critical signalling molecule mediatinghost--tumour interactions t... | One of the vital _hallmarks_ of cancer which distinguishes it from benign tumours is its capability for tissue invasion and distant metastasis ([@bib26]). _Focal_ adhesion _kinase_ (FAK) _is_ _a_ non-receptor protein tyrosine kinase _identified_ _as_ a critical signalling molecule mediating host--tumour interactions _t... |
Background
==========
Myocarditis can present with a wide range of symptoms, ranging from mild dyspnea to chest pain, cardiogenic shock, and fatal arrhythmia. The main cause of myocarditis is current or recent viral infection \[[@B1]\]. Enteroviruses, specifically Coxsackievirus (CV) group B serotypes, have traditiona... | background = = = = = = = = = = myocarditis can present with a wide range of symptoms, ranging from mild dyspnea to chest pain, cardiogenic shock, and severe arrhythmia. the main cause of myocarditis is current or recent viral infected \ [ [ @ b1 ] \ ]. enteroviruses, specifically coxsackievirus ( cv ) group b serotypes... | Background = = = = = = = = = = Myocarditis can present with a wide range of symptoms, ranging from mild dyspnea to chest pain, cardiogenic shock, and fatal arrhythmia. The main cause of myodard&tis is current or recent viral infection \ [[ @ B1] \ ]. Enteroviruses, specifically Coxsackievirus (CV) group B serotypes, ha... | Background ========== Myocarditis can present with a wide range symptoms, ranging from mild dyspnea to chest pain, cardiogenic shock, and arrhythmia. The main cause of myocarditis is current or recent viral infection \[[@B1]\]. Enteroviruses, specifically Coxsackievirus (CV) group B serotypes, have been perceived as th... | BAckGROunD
==========
MYOCARdITis CAn PrESENT WITH A wiDE rANgE oF SymPtOMS, RAngiNG FRoM mIlD dYspNEA to CheSt PAIN, CaRdIOGeNIc ShOcK, and fataL ARRhYTHmia. tHE mAin CAUSe of MYoCARditiS is CURrenT OR RECeNT VIraL INFeCtIoN \[[@b1]\]. eNTeROVIRuses, SpeciFiCALLy coXsAcKieVIrUS (CV) GROUp B seROTYPes, haVE TRaDitIoNa... | Background ========== Myocarditis can present with a wide range ofsymptoms, ranging frommild dyspnea to chest pain, cardiogenic shock, and fatal arrhythmia. The main cause of myocarditis is current orrecent viral infection \[[@B1]\]. Enteroviruses,specifically Coxsackievirus (CV) group B serotypes, have ... | _Background_ ========== Myocarditis can _present_ with a wide range of _symptoms,_ ranging from _mild_ _dyspnea_ _to_ _chest_ pain, _cardiogenic_ shock, and fatal arrhythmia. The main cause of myocarditis _is_ _current_ or recent viral infection \[[@B1]\]. Enteroviruses, specifically Coxsackievirus (CV) _group_ B serot... |
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1. Introduction {#sec0005}
===============
Hydatid bone disease is caused by the *Echinococcus granulosus worm*. This zoonosis is endemic in the Mediterranean, Middle East, Asia, Africa and many South American countries, and it is a major public health and economic problem in the Patagonian region of Argentina. Osseou... | 1. introduction { # sec0005 } = = = = = = = = = = = = = = = hydatid bone fracture is caused by the * echinococcus granulosus worm *. this zoonosis is endemic in the mediterranean, middle east, asia, africa and many south american countries, and it is a major public health and economic problem in the patagonian region o... | 1. Introduction {# sec0005} = = = = = = = = = = = = = = = HydQtKd bone disease is caused by the * Echinococcus granulosus worm *. This zoonosis is endemic in the Mediterranean, Middle East, Asia, Africa and many South American countries, and it is a major public health and economic problem in the Patagonian region of A... | 1. Introduction =============== Hydatid bone disease is caused by the *Echinococcus granulosus This zoonosis is endemic in the Mediterranean, Middle East, Asia, Africa many South American countries, and it is major public health problem in the Patagonian region of Argentina. Osseous involvement accounts for 0.5 %--4 % ... | 1. INtrODUcTIoN {#Sec0005}
===============
hYDatid bOnE dISeASE Is CAUSED By tHE *EChINOcocCuS GRAnulOsuS wORM*. thIS ZOoNOSIS IS ENDeMiC iN tHe MeDIterRANEAn, mIDDle eAsT, aSIa, afRiCA AnD MaNy sOuTH AMERicAN cOUnTRIES, anD IT iS A MAjOR PUBlIc HeAlTH and ECOnomic ProbleM iN the PAtagoNIaN reGion oF aRGEntinA. oSseOu... | 1.Introduction {#sec0005} =============== Hydatid bone disease is caused by the *Echinococcus granulosus worm*. This zoonosis is endemic in the Mediterranean, Middle East, Asia, Africa and manySouth American countries, and it is a major public health andeconomic problemin the Patagonian region of Argent... | 1. Introduction {#sec0005} =============== Hydatid bone disease _is_ caused by the *Echinococcus _granulosus_ worm*. This _zoonosis_ _is_ endemic in _the_ Mediterranean, Middle East, _Asia,_ Africa and many _South_ _American_ countries, and it is a _major_ public health and economic problem in _the_ Patagonian region o... |
Introduction {#s0005}
============
All living organisms require exogenous foods/nutrients for producing energy in the form of ATP, which is needed for numerous cellular functions. Most of the cellular energy is efficiently produced in specialized organelles mitochondria by oxidative phosphorylation. In addition to ene... | introduction { # s0005 } = = = = = = = = = = = = all living organisms require exogenous foods / nutrients for producing energy in the form of hormones, which is needed for numerous cellular functions. most of the cellular energy is efficiently produced in specialized organelles mitochondria by oxidative phosphorylation... | Introduction {# s0005} = = = = = = = = = = = = All living organisms require exogenous foods / nutrients for producing energy in the form of ATP, which is needed for numerous cellular functions. N(st of the cellular energy is efficiently produced in specialized organelles mitochondria by oxidative phosphorylation. In ad... | Introduction {#s0005} ============ All living organisms exogenous foods/nutrients for producing energy in the form ATP, which is for numerous cellular functions. Most of the cellular energy efficiently produced in specialized organelles mitochondria by oxidative phosphorylation. In addition to energy production, mitoch... | inTrOdUCtioN {#S0005}
============
aLL LIvIng oRgAnIsMs reQuirE exogENous foodS/nuTrIEnTs foR proDucIng eneRgY iN THE fOrm of ATP, wHiCH Is neeDED foR nUMeroUS celluLAR funCTiONS. mOsT oF ThE cELlulAr ENeRGy is EFfIcIENtLY producEd iN SPEcIAlizEd OrgANELLes MitOchonDRIA bY oxiDAtive PhOsphOrylaTioN. in ADditION tO ENe... | Introduction {#s0005} ============ All living organisms require exogenous foods/nutrients for producing energy in the form of ATP, which is needed for numerous cellular functions.Most ofthe cellular energy is efficiently produced inspecializedorganelles mitochondria by oxidative phosphorylation. In additiont... | Introduction _{#s0005}_ ============ _All_ living _organisms_ require exogenous foods/nutrients for _producing_ energy in the _form_ of ATP, which is needed for numerous cellular _functions._ Most of the _cellular_ energy _is_ efficiently produced in specialized organelles mitochondria _by_ oxidative phosphorylation. I... |
Introduction
============
Rationale
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Early life experience is a determinant of social inequalities in physical, mental, and social well-being \[[@ref1]-[@ref6]\]. Children living in poverty are more likely to suffer from developmental and health problems, and childhood interventions can decrease incidence an... | introduction = = = = = = = = = = = = rationale - - - - - - - - - early life experience is a determinant of social inequalities in physical, mental, and social well - being \ [ [ @ ref1 ] - [ @ ref6 ] \ ]. children living in poverty are more likely to suffer from developmental and health problems, and childhood interven... | Introduction = = = = = = = = = = = = Rationale - - - - - - - - - Early life experience is a determinant of social inequalities in physical, mental, and social well - being \ [[ @ ref1] - [@ ref6] \ ]. Children living in poverty are more likely to suffer from developmental and health problems, and childhood intervention... | ============ Rationale Early life is a determinant of social inequalities in physical, mental, and social well-being \[[@ref1]-[@ref6]\]. Children living in poverty are more likely suffer from developmental and health problems, and childhood interventions can decrease incidence and prevalence of these problems \[[@ref7... | inTrodUctION
============
rATioNALE
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EaRLY Life expeRieNcE Is A dEtERminaNT Of socIal IneQUaLItIes iN PhysIcaL, menTaL, anD SocIaL well-BEInG \[[@rEF1]-[@rEF6]\]. chILdrEn LivIng IN PoverTY are mOrE LiKELY to suFFER FrOM DeVElopMenTAL aND HEalth prOBlEms, aNd chiLDhoOD iNTErvENtiONs CAn DECReaSE InciDenCe An... | Introduction ============ Rationale --------- Early life experience is a determinant of social inequalities in physical, mental, and social well-being \[[@ref1]-[@ref6]\]. Children living in poverty are more likely to suffer from developmentaland healthproblems, and childhood interventions can... | Introduction _============_ _Rationale_ --------- _Early_ _life_ experience is _a_ determinant of social inequalities in physical, mental, and social well-being \[[@ref1]-[@ref6]\]. _Children_ living in _poverty_ are more likely to suffer from developmental and _health_ problems, and _childhood_ interventions can decre... |
Introduction
============
Classical trace amines (TAs), including tyramine, beta-phenylethylamine (β-PEA), tryptamine and octopamine, have been implicated in a number of neuropsychiatric disorders associated with monoaminergic dysfunction, including schizophrenia, major depression, and Parkinson's disease ([@B9]; [@B7... | introduction = = = = = = = = = = = = classical trace amines ( tas ), including tyramine, beta - phenylethylamine ( β - pea ), tryptamine and octopamine, have been implicated in a number of neuropsychiatric disorders associated with monoaminergic dysfunction, including schizophrenia, major depression, and parkinson ' s ... | Introduction = = = = = = = = = = = = Classical trace amines (TAs ), including tyramine, beta - phenylethylamine (β - PEA ), tryptamine and octopamine, have been i<plicwted in a number of neuropsychiatric disorders associated with monoaminergic dysfunction, including schizophrenia, major depression, and Parkinson ' s fi... | Introduction ============ Classical trace amines including tyramine, beta-phenylethylamine (β-PEA), tryptamine and octopamine, have been in number of neuropsychiatric disorders associated monoaminergic dysfunction, including schizophrenia, major and Parkinson's disease ([@B9]; [@B11]; [@B4]; [@B85]; [@B59]; [@B45]; [@B... | intrOdUCTIon
============
clAssical trAce AMINeS (TAs), iNCLUdIng TYraMIne, Beta-phEnylEtHyLAMIne (Β-peA), trYptAMIne AnD OCtOPAMiNe, HAVe BEEN iMPLiCateD In A nUmber Of nEuROPsYchiATriC DISORDers asSOciatED WiTH MONOAmInERgic dYsfunCtiOn, inclUdiNg SCHIZOphREnIa, MajOr dEpREsSION, AnD paRKInSoN'S DiSEAse ([@B9]; [@b7... | Introduction============ Classical trace amines (TAs), including tyramine, beta-phenylethylamine (β-PEA), tryptamineand octopamine,havebeen implicated in a number of neuropsychiatric disorders associatedwith monoaminergic dysfunction, including schizophrenia, major depression, and Parkinson's disease ([@... | _Introduction_ ============ Classical trace _amines_ (TAs), _including_ _tyramine,_ beta-phenylethylamine (β-PEA), tryptamine and octopamine, have been implicated _in_ a number of neuropsychiatric disorders associated _with_ monoaminergic dysfunction, _including_ schizophrenia, major depression, _and_ Parkinson's disea... |
Background
==========
Protein-protein interactions participate in myriad processes of the cell such as replication, transcription, translation, signal transduction, immune response, metabolism, membrane-associated processes and development (e.g., \[[@B1]-[@B4]\]). Protein-protein interactions offer an excellent way of... | background = = = = = = = = = = protein - protein interactions participate in myriad processes of the cell such as replication, transcription, trafficking, signal transduction, immune response, metabolism, membrane - associated processes and development ( e. g., \ [ [ @ b1 ] - [ @ b4 ] \ ] ). protein - protein interacti... | Background = = = = = = = = = = Protein - protein interactions participate in myriad processes of the cell such as replication, transcription, translation, signal transduction, immune response, metabolism, membrane - associated processes and development (e. g. , \ [[ @ B1] - [@ B4] \] ). Protein - protein interactions o... | Background ========== interactions participate in myriad processes of cell such as transcription, translation, transduction, immune response, metabolism, membrane-associated processes and development (e.g., Protein-protein interactions offer an excellent of combining its working parts, the to achieve large functional d... | bACkGRoUNd
==========
pRoTeIN-PrOteIN InterActIOns pARtICipate in MyRiAD PROCeSses OF THE cEll suCh As replICatiON, TRAnsCrIPtion, TRAnsLAtion, sIGnAL traNsDucTiON, ImMUnE ReSPonSe, MetABoLiSM, MeMBrAnE-AsSOCiATed PRocesSES aND deVeLoPMenT (e.G., \[[@B1]-[@b4]\]). pROteIN-pROTeiN iNTeRACTions OFFeR An eXceLleNt waY OF... | Background ========== Protein-proteininteractionsparticipate in myriad processes of thecell such as replication, transcription,translation,signal transduction, immune response, metabolism,membrane-associated processes and development (e.g., \[[@B1]-[@B4]\]). Protein-protein interactions offer an excellent w... | _Background_ ========== Protein-protein interactions participate _in_ myriad processes of the cell such as _replication,_ transcription, _translation,_ signal transduction, immune response, metabolism, membrane-associated processes and development (e.g., \[[@B1]-[@B4]\]). _Protein-protein_ _interactions_ offer an excel... |
Introduction {#sec1-1}
============
Image-guided Percutaneous Needle Biopsy (PNB) is an interventional procedure performed by radiologists ([@ref1]-[@ref5]) with the aim to obtain cells or tissue for diagnosis by the insertion of a needle into a suspected lesion.
It's a relatively non-invasive procedure, and it has a... | introduction { # sec1 - 1 } = = = = = = = = = = = = image - based percutaneous needle biopsy ( pnb ) is an interventional procedure performed by radiologists ( [ @ ref1 ] - [ @ ref5 ] ) with the aim to obtain cells or tissue for diagnosis by the insertion of a needle into a suspected lesion. this ' s a relatively non -... | Introduction {# sec1 - 1} = = = = = = = = = = = = Image - guided PsrXutaneous Needle Biopsy (PNB) is an interventional procedure performed by radiologists ([ @ ref1] - [@ ref5] ) with the aim to obtain cells or tOssJe for diagnosis by the insertion of a needle into a suspected lesion. It ' s a relatively non - invasive... | Introduction {#sec1-1} ============ Image-guided Percutaneous Needle Biopsy (PNB) is an interventional procedure performed by radiologists ([@ref1]-[@ref5]) with the to obtain cells or tissue for by the insertion of a needle into a suspected lesion. It's a relatively non-invasive procedure, and it has advantages compar... | InTrODucTIoN {#sec1-1}
============
imagE-GuIdeD PerCuTANEOuS neEDLE biopSy (pnb) Is An inTERVentionAL pROCEDurE PerFORmed bY RADIoLogIStS ([@Ref1]-[@reF5]) wITH the aIm to OBtaIn cElLs OR tissUe fOr dIaGnosIs by THe iNsErtiON oF a NeeDle INTO a SuspecTed LeSION.
iT'S a RelaTiveLY noN-INvASivE PrOcEdUre, aND IT haS A... | Introduction{#sec1-1} ============ Image-guided Percutaneous Needle Biopsy (PNB) is an interventional procedure performed by radiologists ([@ref1]-[@ref5]) with the aim toobtain cells or tissue for diagnosis bytheinsertion of a needleinto a suspected lesion. It's a relativelynon-invasive procedure, and it... | Introduction {#sec1-1} ============ Image-guided Percutaneous Needle Biopsy (PNB) _is_ an interventional _procedure_ _performed_ by radiologists ([@ref1]-[@ref5]) _with_ the aim _to_ obtain cells or tissue for diagnosis by the _insertion_ of a _needle_ into a suspected lesion. _It's_ a relatively non-invasive procedure... |
Permafrost temperature has increased by 1°C to 2°C in the Russian north during the last 3 decades ([@CIT0001]). Northern Alaska and northern Canada also have warmed to a comparably high level during the same period ([@CIT0002]). Recent observations indicate that this warming is highly coupled with a shortened winter se... | permafrost activity has increased by 1°c to 2°c in the russian north during the last 3 decades ( [ @ cit0001 ] ). southern alaska and northern canada also have warmed to a comparably high level during the same period ( [ @ cit0002 ] ). recent observations indicate that this warming is highly coupled with a shortened wi... | Permafrost temperature has increased by 1 ° C to 2 ° C in the Russian north during the last 3 decades ([ @ CIT0001] ). Northern Alaska and northern Canada also have warmed to a comparably high level during the same period ([ @ CIT0002] ). Recent observations indicate that this warming is highly coupled with a shortemee... | Permafrost temperature has increased by 1°C to 2°C in the north during the last 3 decades ([@CIT0001]). Northern Alaska and northern also have warmed to a comparably high level the same period ([@CIT0002]). observations indicate that this warming is highly coupled with a shortened season and the degradation of the ice-... | PerMAfrOsT teMpeRatUrE Has INcReaSEd bY 1°C tO 2°C iN the RuSsiAN NorTH DuRIng ThE Last 3 decadeS ([@cIT0001]). NORthERN ALAska AND norTHErn cAnaDa ALSO HavE WarMEd to A coMPARABLY HIgH leveL durING THe SAme pErIod ([@ciT0002]). rEceNt oBsERvaTions iNdiCATe THat thIS waRminG iS hIGhlY Coupled wITH a sHorteNEd WiNtER SE... | Permafrost temperature has increased by 1°C to 2°C in the Russian north during the last 3 decades ([@CIT0001]). Northern Alaska and northernCanada alsohave warmedto a comparablyhighlevel during the same period ([@CIT0002]). Recent observations indicate that this warmingis highly coupled with a shortened wi... | Permafrost _temperature_ has increased by 1°C to _2°C_ in _the_ Russian north during the last 3 _decades_ _([@CIT0001])._ _Northern_ Alaska and northern Canada also have warmed _to_ a comparably high level _during_ the same period ([@CIT0002]). Recent observations _indicate_ _that_ _this_ _warming_ is highly coupled _w... |
Introduction {#S1}
============
The importance of the biological properties of antibodies to specifically engage a target of choice and activate complement and Fc gamma receptors (FcγR) on immune cells ([@B1]) is currently more and more recognized in modern medicine. For cancer therapies using tumor targeting antibodi... | introduction { # s1 } = = = = = = = = = = = = the importance of the biological properties of antibodies to specifically engage a target of choice and involve complement and fc gamma receptors ( fcγr ) on immune components ( [ @ b1 ] ) is currently more and more recognized in modern medicine. for cancer therapies using ... | Introduction {# S1} = = = = = = = = = = = = The importance of the biological properties of antibodies to specifically engage a target of choice and activate complement and Fc gamma receptors (FcγR) on immune cells ([ @ B1] ) is currently more and more recognized in modern medicine. For cancer therapies using tumor targ... | {#S1} ============ The importance of the biological properties of antibodies to specifically engage a target of choice activate complement and Fc gamma receptors on immune cells ([@B1]) is currently more more recognized in medicine. For cancer therapies using tumor targeting antibodies, effector functions are preferred... | intRODUCTion {#s1}
============
tHE impoRTance of ThE BIoLogIcAl propErtIEs Of antiBOdIEs To SPeCIfiCALLY engAge A TARGeT OF ChoiCe and actiVATE CoMpleMent ANd fC GAMmA RECepToRs (fcγr) ON IMMUNe CelLs ([@B1]) Is CURRentLy more AND More REcognIzeD In MOdeRn mEDICinE. FoR caNCER tHeraPiEs uSINg TuMoR tARGETing AntIBoDi... | Introduction {#S1} ============The importance of the biological properties of antibodies tospecifically engage a target of choice and activate complement and Fcgamma receptors (FcγR) on immune cells ([@B1]) is currently more andmorerecognized in modern medicine. For cancer therapies using tumor targeting... | Introduction {#S1} ============ The importance of the biological properties of _antibodies_ _to_ specifically engage _a_ target _of_ choice and activate complement and Fc _gamma_ receptors _(FcγR)_ on immune cells _([@B1])_ is currently more and more recognized _in_ modern _medicine._ For _cancer_ therapies using tumor... |
Deception detection research has primarily focused on developing an understanding of the strategies that individuals employ when lying or telling the truth about solo crimes, and furthermore what interviewing techniques can be employed by investigators to enable individual liars to be more easily differentiated from in... | deception detection research has primarily focused on developing an understanding of the strategies that individuals employ when lying or telling the truth about solo crimes, and furthermore what interviewing techniques need be employed by individuals to enable individual liars to be more easily differentiated than ind... | Deception detection research has primarily focused on developing an understanding of the strategies that individuals employ when lying or telling the truth about solo crimes, and furthermore what interviewing techniques can be employed by investigators to enable individual liars to be more easily differentiated from in... | Deception detection research has focused on developing an understanding of strategies that individuals employ when lying or the truth about solo crimes, and furthermore what interviewing techniques can be employed investigators to enable individual liars to be more easily from truth-tellers (e.g., [@B99]; [@B17]; [@B11... | DECepTiON DeTEcTiOn resEaRch Has pRimArilY fOcuSEd ON DeVeLoPinG aN UndeRsTANdING OF the STRaTEGIEs THaT inDIViDUaLs emPlOy When LYIng OR TeLliNg the trUTh AboUt solO CRiMEs, AND FuRtHERMore whAt INtervIeWINg tEchnIqUES CAn BE emplOYED BY inVestIGaTorS tO EnaBle INDivIduAL LiARs TO BE MOrE EAsIly dIfFErenTiAteD FROM iN... | Deception detectionresearch has primarily focused on developingan understanding of the strategies thatindividualsemploywhen lyingor telling the truthabout solocrimes, and furthermore what interviewing techniques can be employed byinvestigators to enableindividual liars to be more easily differentiated ... | _Deception_ detection research has primarily focused _on_ _developing_ an understanding of the strategies that individuals employ when lying _or_ telling the truth about solo crimes, and _furthermore_ what interviewing techniques can be employed by _investigators_ to enable individual _liars_ to be more _easily_ _diffe... |
Abbreviations used in this paper: bHLH, basic helix-loop-helix; dblKO, double knockout; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MRF, myogenic regulatory factor.
Introduction
============
The process of skeletal muscle differentiation is orchestrated by a family of four conserved basic helix-loop-helix (bHLH)... | abbreviations used in this paper : bhlh, basic helix - loop - helix ; dblko, double knockout ; gapdh, glyceraldehyde - 3 - phosphate dehydrogenase ; mrf, myogenic regulatory factor. introduction = = = = = = = = = = = = the process of skeletal muscle differentiation is orchestrated by a family of four conserved basic he... | Abbreviations used in this paper: bHLH, basic helix - loop - helix; dblKO, double knockout; GAPDH, glyceraldehyde - 3 - phosphate dehydrogenase; MRF, myogenic regulatory factor. Introduction = = = = = = = = = = = = The process of skeletal muscle differentiation is orchestrated by a family of four conserved basic helix ... | Abbreviations used in this paper: bHLH, helix-loop-helix; dblKO, double knockout; glyceraldehyde-3-phosphate dehydrogenase; myogenic regulatory factor. Introduction ============ The process of skeletal muscle differentiation is orchestrated by a family of four conserved basic helix-loop-helix (bHLH) transcription facto... | AbBreviATiONS UsEd iN ThIs PApEr: BHLH, BasIC HELIX-loop-HELIX; DblKo, doUBlE kNockoUt; gAPDH, GLYcEralDEHyDe-3-phOspHate DEHYdrOgENAse; mrF, MyoGEniC ReguLatORy FacTor.
INtRODUCTIon
============
tHE ProcESs of SKELETal MUScLE dIFFEreNtiaTiOn iS OrCheStRatEd bY a FamilY OF FOuR coNserved BASIc hELiX-looP-hELIX (Bhlh)... | Abbreviations usedinthis paper: bHLH, basic helix-loop-helix; dblKO, double knockout; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MRF, myogenic regulatoryfactor. Introduction ============ The processof skeletal muscle differentiation is orchestrated by a family of four conserved basic helix-loop-hel... | Abbreviations used in this paper: bHLH, basic helix-loop-helix; dblKO, double knockout; GAPDH, _glyceraldehyde-3-phosphate_ dehydrogenase; MRF, myogenic regulatory factor. Introduction ============ The _process_ of skeletal _muscle_ _differentiation_ is orchestrated by _a_ family of four conserved basic helix-loop-heli... |
The authors wish to make the following corrections to their paper \[[@B1-ijms-19-02737]\]: We have recently been made aware of some errors and omissions in the following paragraph of our recent paper.
Section 2.2.5, lines 2--6 currently read as follows:
A structure-selective DNA binding of wild-type and G245S mutant ... | the authors wish to make the following corrections to their paper \ [ [ @ b1 - ijms - 19 - 02737 ] \ ] : we have recently been made aware of some errors and omissions in the following paragraph of our recent paper. section 2. 2. 5, lines 2 - - 6 currently read as follows : a structure - selective dna binding of tiger -... | The authors wish to make the following corrections to their paper \ [[ @ B1 - ijms - 19 - 02737] \ ]: We hAfe recently been made aware of siKe errors and omissions in the following paragraph of our recent paper. Section 2. 2. 5, lines 2 - - 6 currently read as follows: A structure - selective DNA binding of wild - type... | The authors wish make the following corrections their paper \[[@B1-ijms-19-02737]\]: We have recently made aware of some errors and omissions in the following paragraph of our recent paper. Section 2.2.5, lines 2--6 currently read follows: A structure-selective DNA binding of wild-type and G245S mutant p53 proteins on ... | tHE autHorS wIsH TO Make THE fOLLOwING CORReCtioNs TO THEir PapeR \[[@b1-ijmS-19-02737]\]: We hAvE reCentLy BEEn MADe awaRE oF soME Errors aNd oMiSsIons in ThE follOwINg PArAgRaPH Of OUR reCENt paPER.
sectIOn 2.2.5, lineS 2--6 CurrentLy rEAD aS fOLLows:
A StRucTuRE-seLeCTIvE DNA bINDINg OF WiLD-TYpe anD G245S mUTanT ... | The authors wish to make thefollowing corrections totheir paper \[[@B1-ijms-19-02737]\]: Wehave recentlybeen madeaware of some errors and omissions in the followingparagraph of our recent paper. Section 2.2.5, lines 2--6 currently read as follows: A structure-selective DNAbinding ofwild-type and G245S... | The authors _wish_ to make the following _corrections_ to _their_ paper \[[@B1-ijms-19-02737]\]: We _have_ recently been made _aware_ of some _errors_ and omissions in the following paragraph _of_ our recent _paper._ _Section_ 2.2.5, lines 2--6 currently read _as_ follows: A structure-selective DNA _binding_ of wild-ty... |
Introduction {#s1}
============
Human thought involves the building of mental representations by integrating external and previously stored information, and their manipulation in a cognitive space: working memory (WM; Baddeley, [@B4]). A prime characteristic of thinking is hence its abstract nature. It always requires... | introduction { # s1 } = = = = = = = = = = = = symbolic thought involves the building of mental representations by integrating external and previously stored information, and possibly manipulation in a cognitive space : working memory ( wm ; baddeley, [ @ b4 ] ). a prime characteristic of thinking is hence its abstract ... | Introduction {# s1} = = = = = = = = = = = = Human thought involves the building of mental representations by integrating external and previously stored information, and their manipulation in a cognitive space: working memory (WM; Baddeley, [@ B4] ). A prime characteristic of thinking is hence its abstract nature. It al... | Introduction {#s1} ============ Human thought involves the building of mental representations by and previously stored information, and manipulation in a cognitive space: working memory (WM; Baddeley, [@B4]). A prime of hence its nature. It requires people to construct representations from the perceptual features of st... | iNtrOdUCtion {#s1}
============
hUMAn thOUgHt iNvOLvES THE builDiNG of meNtaL rEPreSeNtatIons bY InTEgrATiNG ExTeRnAl aND pREVIoUSlY stOreD INforMAtIon, anD TheiR MANIPulaTion in A COgNITIvE SPaCe: WORKiNg MeMorY (wm; BAddElEy, [@B4]). a PRiMe ChArACteRIsTIC of tHINkINg IS hENCE ITS aBstRact nAtUre. IT Always reQUIres... | Introduction {#s1} ============ Human thought involves the building of mentalrepresentations by integrating external andpreviously stored information,and their manipulation in acognitive space: working memory (WM; Baddeley, [@B4]). A prime characteristic of thinking is hence its abstract natu... | Introduction {#s1} ============ Human _thought_ involves _the_ building of mental representations by _integrating_ _external_ and _previously_ stored _information,_ and their _manipulation_ in a cognitive space: working memory (WM; Baddeley, _[@B4])._ A prime characteristic _of_ thinking _is_ hence its abstract nature.... |
Introduction {#Sec1}
============
Metformin is one of the most widely used glucose-lowering agents to treat type 2 diabetes \[[@CR1]\] and is now recommended as the first-line drug therapy by a recent joint consensus statement \[[@CR2]\]. This unique survivor of the biguanides family is prescribed for its effective an... | introduction { # sec1 } = = = = = = = = = = = = metformin is one of the most widely used glucose - lowering agents to treat type 2 diabetes \ [ [ @ cr1 ] \ ] and is now recommended as the first - line drug therapy by a recent joint consensus statement \ [ [ @ cr2 ] \ ]. this unique survivor of the biguanides family is ... | Introduction {# Sec1} = = = = = = = = = = = = Metformin is one of the most widely used glucose - lowering agents to treat type 2 diabetes \ [[ @ CR1] \] and is now recommended as the first - line drug therapy by a recent joint consensus statement \ [[ @ CR2] \ ]. This uniq T# survivor of the biguanides family is prescr... | Introduction {#Sec1} ============ Metformin is one of the most widely used glucose-lowering to treat type 2 diabetes and is now recommended as the first-line drug therapy by a recent joint statement \[[@CR2]\]. This unique survivor of the family is prescribed for its effective anti-hyperglycaemic action, achieving a po... | INTrOduCTiOn {#Sec1}
============
mETFORMIN Is OnE OF THe MOst WiDeLy useD GluCose-LOweRING agenTs TO TReAT TYpe 2 DiabETes \[[@Cr1]\] and Is Now reCOmMenDEd As The fiRsT-LINE drug THERapY bY A reCent JoINT cONsEnsUS sTatEment \[[@Cr2]\]. tHis uniqUE SurvivoR oF THE bIgUaNIDeS FAMilY iS PRESCribED FOR iTS EFfecTIVE AN... | Introduction {#Sec1} ============ Metformin is one of the most widely used glucose-lowering agents to treat type 2 diabetes \[[@CR1]\] and is now recommended as thefirst-line drug therapy by a recent joint consensusstatement \[[@CR2]\].This unique survivor of the biguanides family is prescribed ... | Introduction {#Sec1} ============ Metformin _is_ one of _the_ _most_ widely _used_ glucose-lowering agents _to_ treat _type_ 2 _diabetes_ \[[@CR1]\] _and_ is now recommended as the first-line drug therapy by _a_ recent joint _consensus_ statement \[[@CR2]\]. _This_ unique survivor _of_ _the_ biguanides _family_ is pres... |
Background {#Sec1}
==========
Schizophrenia is a common psychiatric disease with unknown etiology, which symptoms include cognitive dysfunction in addition to positive and negative symptoms \[[@CR1]\]. Cognitive dysfunction, which may reflect genetic susceptibility, is now generally considered to be the core symptom o... | background { # sec1 } = = = = = = = = = = schizophrenia is extremely common psychiatric disease with unknown etiology, which symptoms include cognitive dysfunction in addition to positive and negative symptoms \ [ [ @ cr1 ] \ ]. cognitive abnormalities, which may reflect genetic susceptibility, is now generally conside... | Background {# Sec1} = = = = = = = = = = SchizophreG*a is a common psychiatric disease with unknown etiology, which symptoms include cognitive dysfunction in addition to positive and negative symptoms \ [[ @ CR1] \ ]. Cognitive dysfunction, which may reflect genetic susceptibility, is now generally considered to be the ... | Background {#Sec1} ========== Schizophrenia is a common with unknown etiology, which include cognitive in addition to negative symptoms \[[@CR1]\]. dysfunction, which may genetic susceptibility, is now generally to the core symptom of with pathological mechanisms and related to the abnormal development of the nervous s... | bACKGROunD {#SEc1}
==========
SchiZOphREniA iS A cOmMON psycHiATriC dIseASE WitH uNkNOwn eTiOLOGy, wHiCH SyMPTOMs iNCLuDE COGNITiVE DysFUNCtIon iN aDDitIoN to Positive anD negAtiVE sympTOms \[[@cr1]\]. COGNItiVE DYsFUNCtion, WhicH MAy reFlecT gEnetIc sUScePTIbilItY, iS nOW geneRallY COnsiDerEd to BE The CoRe sYmpTom o... | Background {#Sec1} ========== Schizophreniais a common psychiatricdisease withunknown etiology, whichsymptoms include cognitive dysfunction in addition to positive and negative symptoms \[[@CR1]\].Cognitive dysfunction, which may reflect genetic susceptibility, is now generally consideredto be the core ... | Background _{#Sec1}_ ========== Schizophrenia is a common psychiatric disease with unknown etiology, which symptoms include cognitive dysfunction in addition to positive and negative symptoms \[[@CR1]\]. Cognitive dysfunction, which _may_ reflect genetic susceptibility, is now generally considered to be the core sympto... |
Background {#Sec1}
==========
Contamination of surface and groundwater by trace metals results in the deterioration of water quality which affect human health as well as the health of aquatic ecosystem (Krishna et al. [@CR4]; Bataynen [@CR2]). Trace metals in the aquatic environment creates an immense threat to the ex... | background { # sec1 } = = = = = = = = = = contamination of surface and groundwater by trace metals results in the deterioration of water quality which affect human health as well as the health of aquatic ecosystem ( porter et al. [ @ cr4 ] ; bataynen [ @ cr2 ] ). trace metals in the aquatic environment creates an immen... | Background {# Sec1} = = = = = = = = = = Contamination of surface and groundwater by trace metals results in the deterioration of water quality which affect human health as well as the health of aquatic ecosystem (Krishna et al. [@ CR4 ]; Bataynen [@ CR2] ). Trace metals in the aquatic environment creates an immense thr... | Background {#Sec1} ========== Contamination of surface and groundwater by trace metals results in the deterioration of water quality which affect health as well as the health of aquatic ecosystem (Krishna et al. [@CR4]; Bataynen [@CR2]). Trace metals in the aquatic environment creates an threat to the existence of orga... | backGround {#sec1}
==========
CONtAmInaTiOn OF sURfACe And grOUNdWaTER bY tRAcE meTals rEsULTs In THE deterIorATIon Of waTEr quAlITy WhICh AfFECT hUMan heALth as wELl as THE hEaLtH oF aQUAtIC eCoSYstEM (kRISHnA Et AL. [@cr4]; bAtaYnEn [@Cr2]). tRace mEtAlS in tHE AqUATiC enViROnmeNt cREAteS aN ImMEnSe thREaT to the ex... | Background {#Sec1} ========== Contamination of surface andgroundwater bytracemetals results in the deterioration of water quality which affect human health aswell as the health of aquatic ecosystem (Krishna et al. [@CR4]; Bataynen [@CR2]). Trace metals in the aquatic environment creates an immense threat... | Background {#Sec1} ========== Contamination of surface and groundwater _by_ trace metals results _in_ the deterioration _of_ _water_ quality which affect human health as _well_ as the health of aquatic ecosystem (Krishna _et_ al. [@CR4]; Bataynen [@CR2]). Trace metals _in_ the aquatic environment creates an immense thr... |
1. Introduction
===============
RM 8640 consists of six plastic bottles each containing a 2 mL suspension of polymethyl methacrylate (PMMA) microspheres with a specified amount of immobilized fluorescein isothiocyanate (FITC). The microspheres are intended for calibrating the fluorescence response of flow cytometers \... | 1. introduction = = = = = = = = = = = = = = = rm 8640 consists of six plastic bottles each containing a 2 ml suspension of polymethyl methacrylate ( pmma ) microspheres with a specified amount of immobilized fluorescein isothiocyanate ( fitc ). the microspheres are intended for calibrating the fluorescence response of ... | 1. Introduction = = = = = = = = = = = = = = = RM 8640 consists of six plastic bottles each containing a 2 mL suspension of polymethyl methacrylate (PMMA) microspheres with a specified amount of immobilized fluorescein isothiocyanate (FITC ). The microspheres are intended for calibrating the fluorescence response of flo... | 1. Introduction =============== RM 8640 of six plastic bottles each containing a 2 mL suspension of polymethyl methacrylate (PMMA) microspheres a specified amount of immobilized fluorescein isothiocyanate (FITC). The microspheres are intended calibrating the fluorescence response of flow cytometers \[[@b1-j110-2gai]\].... | 1. iNtRoducTioN
===============
Rm 8640 COnsiSTS Of six plAstIC bOttLEs EAcH contAInInG A 2 mL SusPenSiON oF pOlYMEthYL MethACryLate (pmmA) miCROSPHEres WITh a spECIfIed amOuNT of iMMoBilIZEd fLUOreSceiN isoThioCYaNATE (fITC). The MICRospheRes Are InteNdED fOr caLiBraTIng THE FLUOReSCencE reSpONSe OF flow CyTOmetErs \... | 1. Introduction =============== RM 8640 consists of six plastic bottles each containing a 2 mL suspension of polymethyl methacrylate (PMMA)microspheres with a specifiedamount of immobilized fluorescein isothiocyanate (FITC). The microspheres are intended for calibratingthe fluorescence response ... | 1. _Introduction_ _===============_ RM 8640 consists of six plastic bottles each containing a 2 mL suspension _of_ polymethyl methacrylate (PMMA) microspheres _with_ a specified amount _of_ _immobilized_ fluorescein _isothiocyanate_ (FITC). _The_ _microspheres_ are intended _for_ calibrating the fluorescence response o... |
Introduction
============
hnRNP A1 is an RNA-binding protein that contains two RNA-binding domains (RBDs) and a glycine-rich domain responsible for protein--protein interaction. It is involved in pre-mRNA splicing and transport of cellular RNAs (reviewed by [@cdd462c9]). It is predominantly located in the nucleus, but... | introduction = = = = = = = = = = = = hnrnp a1 is an ion - binding protein that contains two rna - binding domains ( rbds ) and a glycine - rich domain responsible for protein - - protein interaction. it is involved in pre - mrna splicing and transport of cellular rnas ( reviewed by [ @ cdd462c9 ] ). it is not located i... | Introduction = = = = = = = = = = = = hnRNP A1 is an RNA - binding protein that contains two RNA - binding domains (RBDs) and a glycine - rich domain responsible for protein - - protein interaction. It is involved in pre - mRNA splicing and transport of cellular RNAs (reviewed by [@ cdd462c9] ). It is predominantly loca... | Introduction ============ hnRNP A1 is an RNA-binding that contains two RNA-binding domains (RBDs) and glycine-rich domain responsible for protein--protein interaction. It is involved in splicing and transport of cellular (reviewed by [@cdd462c9]). is predominantly located in the nucleus, but also shuttles the nucleus a... | INtroDUCtIOn
============
hNrnP A1 iS aN RNA-bindIng pROteiN THAt ContaIns two rnA-BINdiNg doMaInS (rbdS) aNd A glYciNE-rICH DOmAIN rEsPONsiBlE FoR ProTEIN--pROtEin InteraCtiON. iT IS INVolVeD in pRe-mrna SPlicINg AnD TrANsPORt of cEllULAR rNAs (reviEweD bY [@CDD462c9]). iT is prEDoMInANTlY LOCateD In The nUcLeuS, bUt... | Introduction ============ hnRNP A1 is anRNA-bindingprotein that containstwoRNA-binding domains (RBDs)and a glycine-rich domain responsible for protein--protein interaction. It is involved inpre-mRNA splicing and transport of cellular RNAs (reviewed by [@cdd462c9]). It is predominantlylocated in the nu... | Introduction ============ hnRNP A1 is an _RNA-binding_ protein that contains two RNA-binding domains (RBDs) _and_ a _glycine-rich_ domain responsible for protein--protein interaction. It is involved in pre-mRNA splicing and _transport_ of cellular RNAs (reviewed by [@cdd462c9]). _It_ _is_ predominantly located in _the_... |
{#sp1 .183}
{#sp2 .184}
| ! [ ] ( 229 - 0023 ) { # 235. 183 }! [ ] ( 213 - 283 ) { # 242. 283 } | ! [] (indN#dgaz71076 - 00#e) {# sp1. 183 }! [] (ijdmedgaz7107t - 00!$) {# sp2. 184 } | .183} {#sp2 .184} | {#sp1 .183}
{#SP2 .184}
| {#sp1.183} {#sp2 .184} | {#sp1 .183} _{#sp2_ _.184}_ |
Background
==========
The mammalian inner ear has very limited ability to regenerate lost sensory hair cells \[[@B1],[@B2]\]. While previous studies demonstrate that early postnatal cochlea harbors stem/progenitor-like cells and show a limited regenerative/repair capacity \[[@B3]-[@B13]\], and these properties, howeve... | background = = = = = = = = = = male mammalian inner ear has very limited ability to regenerate lost sensory hair cells \ [ [ @ 2a ], [ @ b2 ] \ ]. while earlier studies demonstrate that early postnatal cochlea harbors stem / progenitor - like cells and show a limited regenerative / healing capacity \ [ [ @ 1a ] - [ @ b... | Background = = = = = = = = = = The mammalian inner ear has very limited ability to regenerate lost sensory hair cells \ [[ @ B1 ], [@ B2] \ ]. While previous studies demonstrate that early postnatal cochlea harbors stem / progenitor - like cells and show a limited regenerative / repair capacity \ [[ @ B3] - [@ B13] \ ]... | Background ========== The mammalian inner has very limited ability to regenerate sensory hair cells While previous studies demonstrate that early postnatal cochlea harbors stem/progenitor-like cells and a limited regenerative/repair \[[@B3]-[@B13]\], and these properties, however, are progressively lost later during th... | bacKgrOund
==========
ThE mamMALiaN iNneR Ear Has VErY Limited ABIlitY to reGENeraTe LOst seNSORy hAIR celLS \[[@B1],[@B2]\]. WHILE PReviouS StudIes demOnstrATe That EArLy poSTNaTAl cOCHLea HARBoRS STEM/prOGenitoR-LIkE cells AnD sHoW a lImitEd rEgeNeRATiVE/rEPaiR CApaCItY \[[@B3]-[@B13]\], aNd thEse proPeRTieS, HOweve... | Background========== Themammalianinner ear has very limited ability to regenerate lost sensoryhair cells \[[@B1],[@B2]\]. While previous studies demonstrate that early postnatal cochlea harbors stem/progenitor-like cells and show a limitedregenerative/repair capacity\[[@B3]-[@B13]\], and these properti... | Background ========== The _mammalian_ inner ear has very limited ability to _regenerate_ lost _sensory_ hair _cells_ \[[@B1],[@B2]\]. While previous studies demonstrate _that_ early postnatal _cochlea_ harbors stem/progenitor-like _cells_ and _show_ _a_ limited regenerative/repair capacity \[[@B3]-[@B13]\], and these p... |
###### Article summary
Article focus
=============
- Hypertension carries significant risks but is commonly poorly managed and controlled.
- Telehealth technology appears to be a useful strategy for managing chronic conditions; however equipment deployed is often complex and costly.
- Use of a new, simple and... | # # # # # # article summary article focus = = = = = = = = = = = = = - hypertension carries significant risks but is commonly poorly managed and controlled. - telehealth technology appears to be a useful strategy for managing chronic conditions ; however equipment deployed is often complex and costly. - use of a new, sa... | # # # # # # Article summary Article focus = = = = = = = = = = = = = - Hypertension carries significant rismQ but is commonly poorly managed and controlled. - Telehealth technology appears to be a useful strategy for managing chronic conditions; however equipment deployed is often complex and costly. - Use of a new, sim... | Article summary Article focus ============= - Hypertension carries significant risks but is commonly managed and controlled. - Telehealth technology appears to be a useful strategy for managing chronic conditions; however equipment deployed often complex and costly. - Use of new, simple and low-cost telehealth interven... | ###### artiCLe summaRY
artiCle FOcUs
=============
- HyPerTEnsIoN cArRIeS sigNifiCAnT RiSks BuT IS cOMmONLy pOorly manaGED AND CoNTrOllEd.
- tElEHeALtH techNOlogy AppEars To BE A uSEful StrAtEgy foR MaNAgInG chrOnIc CondITioNs; hOweVEr eQUipMenT DePLOyeD Is OftEN COMPLeX And cOSTLy.
- use oF A NeW, simPLe ANd... | ###### Article summary Article focus ============= - Hypertensioncarries significant risks but is commonlypoorly managed and controlled. - Telehealth technology appears to be a useful strategy for managing chronic conditions; however equipment deployed is often complex and costly. - Useof a new, simple and... | ###### Article _summary_ Article focus ============= - _Hypertension_ carries significant _risks_ but is commonly poorly managed and controlled. _-_ Telehealth technology appears to be a useful strategy for managing chronic conditions; _however_ equipment deployed is often _complex_ and _costly._ - Use of a new, simple... |
Findings
========
*Taenia solium*is a cestode parasite that causes human neurocysticercosis, a public health problem in developing countries. The life cycle includes the adult tapeworm that grows in the human small intestine and cysticerci, the larval stage, which lodge in pig skeletal muscle and brain. The tapeworm h... | findings = = = = = = = = * taenia solium * is a cestode parasite that causes human consumption, a public health problem in developing countries. the life cycle includes the adult tapeworm that grows in the human small intestine and cysticerci, the larval stage, which lodge in pig skeletal muscle and brain. the tapeworm... | Findings = = = = = = = = * Taenia solium * is a cestode parasite that causes human neurocysticercosis, a public health problem in developing countries. The life cycle includes the adult tapeworm that Nrlws in the human small intestine and cysticerci, the larval stage, which lodge in pig skeletal muscle and brain. The t... | Findings *Taenia solium*is a cestode parasite that causes human public health problem in developing countries. The life cycle includes the adult tapeworm grows in the human small intestine and cysticerci, the larval stage, which in pig skeletal brain. The tapeworm has a scolex that anchors in the intestinal mucosa and ... | fiNDingS
========
*TAenia SolIuM*is A cEsToDe pArASite tHat cAuSeS HUMAN NEuRoCysTIcercOsIs, a PUBLiC HeaLtH proBLem iN DEvEloPing cOuntRieS. THe LiFE Cycle Includes the AduLT TaPEWORm tHAt gROws in tHE human SmAll intEstiNe AND CySTicerci, THE LaRvAL StAgE, wHICH LODGe IN pIG SkeLETaL mUSclE aND brAIN. ThE TaPeWORM H... | Findings ======== *Taenia solium*is a cestodeparasite that causes human neurocysticercosis, a public health problem in developing countries. The life cycle includes the adult tapeworm that grows in the human small intestine and cysticerci, the larval stage, which lodge in pig skeletal muscle and brain... | Findings ======== _*Taenia_ solium*is a cestode parasite that causes human neurocysticercosis, a public health problem in _developing_ countries. The life cycle includes the _adult_ tapeworm _that_ grows in the human small intestine and cysticerci, the larval _stage,_ which _lodge_ in pig _skeletal_ muscle _and_ brain.... |
Introduction
============
Given their rapid proliferation and high specificity, phages are extensively used in several applications, including rapid detection of pathogenic bacteria ([@B33]), assessment of water quality and sewage treatment efficiency ([@B10]), and classification and identification of bacterial specie... | introduction = = = = = = = = = = = = given their rapid proliferation and high specificity, phages are extensively used in several areas, including rapid detection of pathogenic bacteria ( [ @ b1 ] ), assessment of water quality and sewage treatment efficiency ( [ @ b10 ] ), and classification and identification of bact... | Introduction = = = = = = = = = = = = Given their rapid proliferation and high specificity, phages are extensively used in several applications, including rapid detection of pathogenic bacteria ([ @ B33] ), assessment of water quality and sewage treatment efficiency ([ @ B10] ), and classification and identification of ... | Introduction ============ Given their rapid and high specificity, phages are extensively used in several applications, including rapid of pathogenic bacteria ([@B33]), assessment of water quality and sewage treatment ([@B10]), classification and identification of bacterial species ([@B29]). These applications phages ar... | iNtrODuCTIoN
============
GIvEN THEir rApId proLiFERAtiON aNd HIGH sPECiFiCiTY, phagEs ArE eXtenSivELy uSEd IN SevERAL aPpLIcaTions, InClUdIng rapId DeTECtIon of PaThOgeNiC BacteRia ([@B33]), ASSeSSmenT Of WATEr quAlItY And seWaGE TreAtMENt eFFICieNcy ([@B10]), anD clASSIfiCAtION aND iDEntiFiCAtIOn oF bAcTERiAl SPeCIE... | Introduction ============ Given their rapid proliferation and high specificity, phages are extensively used in several applications, includingrapid detectionof pathogenic bacteria ([@B33]),assessment of water quality and sewage treatment efficiency ([@B10]), and classificationand identification of bacterial ... | Introduction ============ Given their rapid proliferation and high specificity, phages are extensively used in several applications, including rapid detection _of_ pathogenic bacteria ([@B33]), assessment of water quality _and_ sewage treatment efficiency _([@B10]),_ and _classification_ _and_ identification of bacteri... |
Introduction
============
Nitric oxide (NO) functions widely as a transmitter in the central and peripheral nervous systems, exerting its physiological effects by stimulating receptors having intrinsic guanylyl cyclase activity, thereby leading to cGMP accumulation in target cells ([@b17]). cGMP can then engage a numb... | introduction = = = = = = = = = = = = nitric oxide ( no ) functions widely as a transmitter in the central and peripheral nervous systems, exerting its physiological effects by stimulating receptors having intrinsic guanylyl cyclase activity, thereby leading to cgmp accumulation in target cells ( [ @ c1 ] ). cgmp can th... | Introduction = = = = = = = = = = = = Nitric oxide (NO) functions widely as a transmitter in the central and peripheral nervous systems, exerting its physiological effects by stimulating receptors having intrinsic guanylyl cyclase activity, thereby leading to cGMP accumulation in target cells ([ @ b17] ). vGML can then ... | Introduction ============ Nitric oxide (NO) functions widely as a transmitter in the central and nervous systems, exerting its physiological effects receptors intrinsic guanylyl cyclase activity, thereby leading to cGMP accumulation in target cells ([@b17]). cGMP can then engage a number of cGMP-dependent protein kinas... | iNtrodUCtioN
============
NItRIc OXide (nO) fuNcTioNS WidElY As A TRANsMItter iN tHE CeNtRal aND perIPHerAl NerVOuS SysTeMS, exErtING iTs PhYsiOloGICaL EFfECts by StIMUlaTING recEpTORs hAving inTRInsiC GUANYlyl cYclASe acTIvity, tHerEBy leadINg To cGmP AcCumuLatioN iN TARget cELLS ([@b17]). cgmp CAn tHen EnGagE a NUmb... | Introduction ============ Nitric oxide (NO) functions widely asa transmitter in the central and peripheral nervous systems, exerting its physiological effects by stimulating receptors having intrinsic guanylyl cyclase activity, thereby leading to cGMP accumulation in target cells ([@b17]). cGMP can then... | Introduction ============ Nitric oxide (NO) _functions_ widely _as_ _a_ transmitter in the central and _peripheral_ nervous systems, exerting its physiological _effects_ by stimulating receptors having intrinsic _guanylyl_ cyclase _activity,_ thereby leading _to_ cGMP accumulation in target cells ([@b17]). cGMP can _th... |
Introduction
============
Studies investigating rider posture during horseback riding are beginning to emerge in the literature with a common theme being asymmetry in riders ([@b24-jhk-42-113]; [@b10-jhk-42-113]; [@b38-jhk-42-113]; [@b32-jhk-42-113]; [@b11-jhk-42-113]). Since the ability to train the horse to be ambid... | introduction = = = = = = = = = = = = studies investigating rider posture during horseback riding are beginning to grow in the literature with a common theme being asymmetry in riders ( [ @ b24 - jhk - 42 - 113 ] ; [ @ b10 - jhk - 42 - 113 ] ; [ @ a1 - jhk - 42 - 113 ] ; [ @ b32 - jhk - 42 - 113 ] ; [ @ b11 - jhk - 42 -... | Introduction = = = = = = = = = = = = Studies investigating rider posture during horseback riding are beginning to emerge in the literature with a common theme being asymmetry in riders ([ @ b24 - jhk - 42 - 113 ]; [@ b10 - jhk - 42 - 113 ]; [@ b38 - jhk - 42 - 113 ]; [@ b32 - jhk - 42 - 113 ]; [@ b11 - jhk - 42 - 113] ... | ============ Studies investigating rider posture during horseback riding are beginning to emerge in the literature with a common theme being in riders ([@b24-jhk-42-113]; [@b10-jhk-42-113]; [@b38-jhk-42-113]; [@b32-jhk-42-113]; [@b11-jhk-42-113]). the to train the horse to ambidextrous is highly desirable, rider asymme... | iNtRodUcTIon
============
STUdIes inveStiGATINg RiDer POsture DUriNg hoRSEBACk riDINg ARe BeginNing tO EMeRge In the litErAtuRe WiTh A COmMOn ThEMe beInG ASYMMeTRy In RidERs ([@B24-JhK-42-113]; [@B10-jhK-42-113]; [@B38-jhK-42-113]; [@B32-jHK-42-113]; [@B11-Jhk-42-113]). siNCE tHe ABiLITy TO train THE HoRsE to BE aMbid... | Introduction============ Studies investigating rider posture during horseback riding are beginning to emerge in the literature with acommon theme being asymmetry in riders ([@b24-jhk-42-113]; [@b10-jhk-42-113]; [@b38-jhk-42-113]; [@b32-jhk-42-113]; [@b11-jhk-42-113]). Since the ability to train thehorse ... | Introduction ============ Studies investigating rider posture during horseback riding _are_ _beginning_ _to_ emerge in the literature with a _common_ theme being asymmetry in riders ([@b24-jhk-42-113]; [@b10-jhk-42-113]; [@b38-jhk-42-113]; [@b32-jhk-42-113]; [@b11-jhk-42-113]). Since the ability to train the horse to _... |
INTRODUCTION {#S1}
============
Healthy People 2020, the federal public health agenda, has set a goal of "Increase(ing) the proportion of persons with hemoglobinopathies who receive disease-modifying therapies"^[@R1]^. For the vast majority of people with sickle cell disease (SCD), the Healthy People goal will be reac... | introduction { # s1 } = = = = = = = = = = = = healthy people 2020, the global public health agenda, has set a goal of " increase ( ing ) the proportion of persons with hemoglobinopathies who receive disease - specific therapies " ^ [ @ r1 ] ^. for the vast majority of people with growth cell disease ( scd ), the health... | INTRODUCTION {# S1} = = = = = = = = = = = = Healthy People 2020, the federal public health agenda, has set a goal of " Increase (ing) the proportion of persons with hemoglobinopathies who receive disease - modifying therapies " ^ [@ R1] ^. For the vast majority of people with sickle cell disease (SCD ), the Healthy Peo... | INTRODUCTION {#S1} ============ Healthy 2020, the federal public health agenda, has a goal of "Increase(ing) the of persons with hemoglobinopathies who receive disease-modifying therapies"^[@R1]^. For the vast majority of people with sickle cell disease (SCD), the Healthy People goal will be reached through increased u... | INTrODuctiOn {#s1}
============
healthy PeoPle 2020, THe FEdErAL PUBlIC hEAlth AgeNDa, has SeT a gOAl Of "INcRease(iNG) THe PrOpoRTiON of PErSOns wITh heMOgLobinopatHiEs Who RecEIVE diSEase-MOdifYiNG tHErApiES"^[@r1]^. fOr tHE VASt maJoRITY Of pEople WItH SickLe ceLL DiseAse (scd), ThE hEALThy PEOple goAL wILL be reAC... | INTRODUCTION {#S1} ============ Healthy People2020, the federal public health agenda, has set a goal of "Increase(ing) the proportion of persons with hemoglobinopathies who receive disease-modifying therapies"^[@R1]^. For the vast majority of people with sickle celldisease(SCD),the Healthy People goal will be ... | INTRODUCTION {#S1} ============ Healthy People _2020,_ the federal public health agenda, has set a goal of "Increase(ing) the proportion of persons _with_ hemoglobinopathies who receive disease-modifying therapies"^[@R1]^. For _the_ _vast_ majority _of_ people with sickle cell _disease_ (SCD), the Healthy _People_ _goa... |
Oropharyngeal dysphagia is a deglutition disorder resulting from neurological and/or structural impairment that may result in in decreased social interaction, loss of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high morbidity processes. Patients with heart disease f... | oropharyngeal dysphagia is a deglutition disorder resulting from neurological and / or structural dysfunction that may present in in decreased social interaction, loss of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high morbidity processes. patients with heart disea... | Oropharyngeal dysphagia is a deglutition disorder resulting from neurological and / or structural impairment that may result in in decreased social interaction, loss of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high morbidity processes. Patients with heart disease... | Oropharyngeal dysphagia is a deglutition disorder resulting from neurological and/or structural impairment that may result in decreased interaction, of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high morbidity processes. Patients with heart disease various causes p... | OrOphARYnGeAL DySpHAgia is a dEgLUTItiOn dISORDeR resULtING FRom NeUrOLoGIcAl AND/or STRuCtuRAl iMpAIRMENT tHAT MAy resuLT in iN DECreASeD sOciAl INtERaCTiOn, loSS oF PleasURE in FoOd cONSUmPtIon, malnutrItIOn, dEhYdrATION, inFEctioUS PULMoNaRy ProCeSsEs aNd OthEr higH MOrBidITy pROcesSEs. PatiENts With HEART dISeASE F... | Oropharyngeal dysphagia is a deglutitiondisorder resulting from neurological and/or structural impairment that may result in in decreasedsocial interaction, loss of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high morbidity processes. Patients wit... | _Oropharyngeal_ dysphagia _is_ a deglutition _disorder_ _resulting_ from neurological and/or structural _impairment_ that may result in _in_ decreased _social_ interaction, loss of pleasure in food consumption, malnutrition, dehydration, infectious pulmonary processes and other high _morbidity_ processes. Patients with... |
Introduction {#s0001}
============
ABP 215 (US: MVASI™ \[bevacizumab-awwb\] approved in September 2017; EU: MVASI™ \[bevacizumab\] approved in January 2018; Amgen Inc.) is a biosimilar to bevacizumab (Avastin®), a recombinant humanized monoclonal immunoglobulin G1 (IgG1) antibody. Bevacizumab binds to vascular endothe... | introduction { # align } = = = = = = = = = = = = abp 215 ( us : mvasi™ \ [ bevacizumab - awwb \ ] approved in september 2017 ; eu : mvasi™ \ [ bevacizumab \ ] approved in january 2018 ; amgen inc. ) is a biosimilar to bevacizumab ( avastin® ), a recombinant humanized monoclonal antibodies g1 ( igg1 ) antibody. bevacizu... | Introduction {# s0001} = = = = = = = = = = = = ABP 215 (US: MVASI ™ \ [bevacizumab - awwb \] approved in September 2017; EU: MVASI ™ \ [bevacizumab \] approved in January 2018; Amgen Inc.) is a biosimilar to bevacizumab (Avastin ® ), a recombinant humanized monoclonal immunoglobulin G1 (IgG1) antibody. Bevacizumab bind... | Introduction {#s0001} ============ ABP (US: MVASI™ \[bevacizumab-awwb\] approved in September 2017; EU: MVASI™ \[bevacizumab\] approved in January 2018; Amgen Inc.) is a biosimilar to (Avastin®), recombinant humanized monoclonal immunoglobulin G1 (IgG1) antibody. Bevacizumab binds to vascular endothelial growth factor ... | inTroductioN {#S0001}
============
abP 215 (uS: MVasi™ \[BEVACiZUmAb-awwB\] apPROved in sEPtEMBEr 2017; eU: mvAsi™ \[BevaCiZuMAB\] APpRoved IN JaNUAry 2018; AMGEn iNc.) iS a bIOSiMILAR tO bEvAcIzUmab (AVastiN®), A RECOmBiNAnt hUmanizeD mONOclOnAL iMmUnOGLObULin g1 (Igg1) antIBoDY. bevAcizumab bInds TO VAScULAr enDOthE... | Introduction {#s0001} ============ ABP 215 (US:MVASI™ \[bevacizumab-awwb\] approvedin September2017; EU: MVASI™ \[bevacizumab\] approvedin January2018; Amgen Inc.) is a biosimilar to bevacizumab (Avastin®), a recombinanthumanized monoclonal immunoglobulin G1 (IgG1) antibody. Bevacizumab binds to vascular end... | Introduction {#s0001} ============ _ABP_ 215 (US: MVASI™ \[bevacizumab-awwb\] approved in _September_ 2017; EU: MVASI™ \[bevacizumab\] approved in January 2018; Amgen _Inc.)_ _is_ a biosimilar to _bevacizumab_ _(Avastin®),_ a recombinant humanized monoclonal immunoglobulin G1 (IgG1) antibody. _Bevacizumab_ binds to vas... |
Background
==========
Duck plague virus (DPV), or duck enteritis virus (DEV), is an important pathogen of ducks, which has caused serious losses in commercial duck production in domestic and wild waterfowl as a result of mortality, condemnations, and decreased egg production\[[@B1]\]. DPV is classified as the subfamil... | background = = = = = = = = = = duck plague virus ( dpv ), or duck enteritis virus ( dev ), is an important pathogen of ducks, which has caused serious losses in commercial duck production in domestic and asian waterfowl as a result of mortality, condemnations, and decreased egg production \ [ [ @ b1 ] \ ]. dpv is class... | Background = = = = = = = = = = Eufk plague virus (DPV ), or duck enteritis virus (DEV ), is an important pathogen of ducks, which has caused serious losses in commercial duck production in domestic and wild waterfowl as a result of mortality, condemnations, and decreased egg production \ [[ @ B1] \ ]. DPV is classified... | Background ========== Duck plague virus (DPV), or duck enteritis virus (DEV), is important pathogen of ducks, which has caused serious losses in commercial duck production in domestic wild waterfowl as result of mortality, condemnations, and decreased egg production\[[@B1]\]. DPV is the subfamily alphaherpesvirinae of ... | baCKgrOUNd
==========
DucK PLAGue vIruS (dpV), Or duCK entERiTis VirUs (DEv), Is AN imporTANt PathogeN Of DucKs, WhICh hAs cAuseD sERioUS LosseS In cOmmErCIAL duck PRodUCtIOn IN DoMEStIC AnD wILd wAteRfOWL AS a reSuLt OF MoRTaLiTy, cONDEmNAtionS, aNd DECreASed EGG pROdUctioN\[[@B1]\]. DPv is CLASSiFIeD aS the SubfAMIL... | Background ========== Duck plague virus (DPV), or duckenteritis virus (DEV), is an important pathogen of ducks,which has caused serious losses in commercial duck production indomestic and wildwaterfowl as aresult of mortality, condemnations,and decreased egg production\[[@B1]\]. DPV is classified as th... | _Background_ ========== Duck plague virus (DPV), _or_ duck enteritis virus (DEV), is an important pathogen of _ducks,_ which has caused serious losses in _commercial_ _duck_ production in domestic and wild waterfowl as _a_ result of mortality, condemnations, _and_ decreased _egg_ production\[[@B1]\]. DPV is classified ... |
Introduction
============
Obesity and osteoporosis are two important global health problems with an increasing prevalence and a high impact on both mortality and morbidity.[@b1-dmso-4-273]--[@b4-dmso-4-273] Interestingly, during recent decades, both diseases have become a major health threat worldwide.[@b2-dmso-4-273]... | introduction = = = = = = = = = = = = obesity and osteoporosis are two important global health problems with an increasing prevalence and a high impact on both mortality and morbidity. [ @ b1 - dmso - 6 - 273 ] - - [ @ b4 - dmso - 4 - 273 ] however, during many decades, both diseases have become a major health threat wo... | Introduction = = = = = = = = = = = = Obesity and osteoporosis are two important global health problems with an increasing prevalence and a high impact on both mortality and morbidity. [@ b1 - dmso - 4 - 273] - - [@ b4 - dmso - 4 - 273] Interestingly, during recent decades, both diseases have become a major health threa... | Introduction ============ Obesity and osteoporosis are two important global health problems with an increasing prevalence and a high impact on both mortality and morbidity.[@b1-dmso-4-273]--[@b4-dmso-4-273] Interestingly, during recent decades, both diseases have major health threat worldwide.[@b2-dmso-4-273] Age and f... | inTRodUctiON
============
oBesitY aNd osTEoporOSiS ArE TwO imPOrtAnT gLOBal hEalTH prOBLeMS wiTH AN inCrEaSiNG pRevaLEnCe ANd a HIGH iMPACt oN both MorTAlITY and morbIDITy.[@b1-DMSo-4-273]--[@b4-dMSo-4-273] IntErESTIngLY, DurinG REcENT DEcADeS, boTH dIsEAseS hAVe BeCOME a mAjOr HEaltH tHReAt wOrlDWide.[@b2-dMso-4-273]... | Introduction ============ Obesity and osteoporosis are two important global health problems withanincreasing prevalence and a high impact on both mortalityand morbidity.[@b1-dmso-4-273]--[@b4-dmso-4-273] Interestingly, during recent decades,both diseases have becomea major health threat worldwide.[@b2-dmso-4-273] ... | Introduction _============_ Obesity and osteoporosis _are_ two important global health problems with an increasing prevalence and a _high_ impact on both mortality and morbidity.[@b1-dmso-4-273]--[@b4-dmso-4-273] Interestingly, during recent decades, both _diseases_ have _become_ a major health threat worldwide.[@b2-dm... |
Introduction
============
Cognitive impairment is a frequently reported issue for patients with fragile X syndrome (FXS), which is the most common form of inherited intellectual disability, and the leading single gene cause of autism spectrum disorder ([@B37]; [@B26]; [@B1]). This syndrome is caused by the transcripti... | introduction = = = = = = = = = = = = cognitive impairment is this frequently reported issue for patients with fragile x syndrome ( fxs ), which is the most common form of inherited intellectual disability, and the leading single gene cause of autism spectrum disorder ( [ @ b37 ] ; [ @ b26 ] ; [ @ b1 ] ). this syndrome ... | Introduction = = = = = = = = = = = = Cognitive impairment is a frequently reported issue for patients with fragile X syndrome (FXS ), which is the most common form of inherited intellectual disability, and the leading single gene cause of autism spectrum disorder ([ @ B37 ]; [@ B26 ]; [@ B1] ). This syndrome is caused ... | Introduction ============ Cognitive is a frequently reported issue patients fragile X syndrome (FXS), which is the common form of inherited intellectual disability, and the leading gene cause of autism spectrum ([@B37]; [@B26]; [@B1]). This syndrome is caused by the transcriptional silencing of the fragile X mental ret... | iNTrodUCtIoN
============
cOGnITIVE imPaiRMENt iS A FrequEntLY repORTEd isSUe For pATiEnTs wITh FragILE x sYndRoME (FXS), WHiCh is tHe mOsT commoN fOrM of InheRited inTElLeCTUaL diSAbILiTY, anD THe LEADiNg SInGLE GEnE cauSe of auTISM spEcTruM diSOrDeR ([@b37]; [@b26]; [@B1]). thIs SyndrOme IS CauSED BY thE TRaNscrIPti... | Introduction ============Cognitive impairmentis afrequently reported issue for patients withfragile X syndrome (FXS), which is the most common form of inherited intellectual disability,and the leading single genecause of autism spectrum disorder ([@B37]; [@B26];[@B1]). This syndrome is caused by the trans... | Introduction ============ Cognitive impairment is a frequently reported _issue_ for _patients_ _with_ _fragile_ X syndrome (FXS), which _is_ _the_ most common form of inherited intellectual _disability,_ and _the_ leading single _gene_ cause of autism spectrum disorder ([@B37]; [@B26]; [@B1]). This syndrome is caused b... |
{#sp1 .111}
| ! [ ] ( 4 - 13 ) { # 10. 111 } | ! [] (iBdmedgaz71y72 - 005o) {# sp1. 111 } | {#sp1 .111}
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Introduction {#section5-2050312120915399}
============
Collaboration within medical research accelerates innovation and promotes complex scientific endeavors. Technological advances facilitating communication and the ability to record and share data have simplified the collaborative process, revolutionizing contempora... | introduction { # section5 - 2050312120915399 } = = = = = = = = = = = = collaboration within medical research accelerates innovation and promotes complex scientific endeavors. technological advances facilitating communication and the ability to record and share data have simplified the collaborative process, revolutioni... | Introduction {# section5 - 2050312120915399} = = = = = = = = = = = = Collaboration within medical research accelerates innovation and promotes complex scientific endeavors. Technological advances facilitating communication and the ability to record and share data have simplified the collaborative process, revolutionizi... | {#section5-2050312120915399} ============ within medical accelerates innovation and promotes complex scientific endeavors. Technological advances facilitating communication and the ability to record and share data simplified the collaborative process, revolutionizing contemporary research practices. Not surprisingly, h... | INtroduCTIoN {#SectION5-2050312120915399}
============
COlLAbOrAtiON wIThIN MedICAl ReSEARCh aCCElERatEs INnovATiON ANd proMOTES complex sCientiFiC EnDeAVOrs. teCHNoLogical AdvANCeS faCiLItATiNg COMMuNicAtIon AnD THE abilitY tO RECOrD ANd SHare DATa HAvE sIMplifIeD tHe cOLlabOrATIvE pRocess, revOLUtIOnIZInG ContEMPORa... | Introduction {#section5-2050312120915399} ============ Collaboration within medical research accelerates innovationand promotes complex scientificendeavors. Technological advances facilitating communication andthe ability to record and share data have simplified the collaborativeprocess,revolutionizing con... | _Introduction_ {#section5-2050312120915399} ============ Collaboration _within_ medical research _accelerates_ innovation and promotes complex scientific _endeavors._ Technological advances facilitating communication and the ability to record and _share_ data have simplified the collaborative process, revolutionizing c... |
Background
==========
The incidence of melanoma in Europe has been steadily increasing, more rapidly than for any other cancer, during recent decades. Incidence of melanoma deeply varies across Europe, with the highest incidence in Scandinavian countries.
Lifetime risk of developing melanoma within the entire caucasi... | background = = = = = = = = = = the incidence of melanoma in europe has been steadily increasing, more rapidly than for any other cancer, during recent years. incidence of melanoma deeply varies across europe, with the highest incidence in scandinavian countries. lifetime risk of developing melanoma within the entire ca... | Background = = = = = = = = = = The incidence of melanoma in Europe has been steadily increasing, more rapidly than for any other cancer, during recent decades. Incidence of melanoma deeply varies across Europe, with the highest incidence in Scandinavian countries. Lifetime risk of developing melanoma within the entire ... | Background ========== The of melanoma in Europe has been steadily increasing, more than for other cancer, during recent decades. Incidence of melanoma deeply varies across Europe, with the highest incidence Scandinavian countries. Lifetime risk of developing melanoma the entire caucasian population estimated be 1:535 i... | BAcKGrouNd
==========
tHE inCideNCE Of mElANoMA in EUROPE HaS BEEN steADilY iNcReasinG, more rapiDlY THAn foR ANy otHer CancEr, DUriNg RecEnT deCADes. IncIdEnCE Of MELAnOma DeepLY VARiEs acrOSs eurOpe, wiTH thE hIgheST incIdeNce IN SCANdInaVian COunTRIes.
LIfeTIme RiSk OF DEVEloping MeLanOMa witHin The eNtiRE CAuCAsi... | Background ========== The incidence of melanomain Europe has been steadily increasing, more rapidly than for anyother cancer, during recent decades.Incidence of melanoma deeply varies across Europe, with the highest incidenceinScandinavian countries. Lifetime risk of developing melanoma within the ent... | _Background_ ========== The incidence _of_ melanoma _in_ Europe has _been_ steadily increasing, more _rapidly_ _than_ _for_ any other cancer, during recent decades. Incidence _of_ _melanoma_ deeply varies across Europe, with _the_ _highest_ incidence in Scandinavian countries. Lifetime risk of developing _melanoma_ wit... |
Aims and Scope
==============
*Clinical Case Reports* is different to other case report journals. Our aim is to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. We welcome case reports, clinical images, and procedural videos from all ar... | aims and scope = = = = = = = = = = = = = = * clinical case reports * is different to other case report journals. our aim is to directly improve global health outcomes and share clinical findings using case reports to convey important best practice messages. we welcome case reports, clinical images, and procedural video... | Aims and Scope = = = = = = = = = = = = = = * Clinical Case Reports * is different to other case report journals. Our aim is to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. We welcome case reports, clinical images, and procedural vide... | Aims and Scope ============== *Clinical Case Reports* is different to other case report journals. Our aim is to directly improve global health outcomes and share clinical knowledge case reports to convey important best practice messages. We case reports, clinical images, and procedural videos from all areas Medicine, N... | AIMS And sCOpE
==============
*cLInICaL CasE rePoRTS* is dIFFEReNt tO oTheR CAsE rePort jOUrNALS. OuR AIm IS to DIrEcTlY imprOVe glOBal hEaLth OUtcoMes anD sHaRe cLinIcAL KNoWLeDGe USING CASe rEporTS to coNVEy imporTAnt beST PractIce meSsAgeS. we WELcOmE caSe rEPoRts, CLINicAl imAGES, And PROCEduRAL VideoS FROM aLL AR... | Aims and Scope ============== *ClinicalCase Reports* is different to othercase report journals. Our aim is to directlyimprove global health outcomes and share clinical knowledge using case reports toconveyimportant best practice messages. We welcome case reports, clinical images, and procedural vide... | _Aims_ _and_ Scope ============== *Clinical Case _Reports*_ is _different_ _to_ other case report journals. Our aim is _to_ directly improve _global_ health outcomes and share clinical knowledge using case reports _to_ convey important best practice messages. We welcome case reports, _clinical_ images, and procedural v... |
Background {#Sec1}
==========
Stillbirth and its consequences have attracted some research interest. However, there still remains an uncertainty particularly about how to advise medical staff of the necessary steps that should be taken around stillbirth bereavement care. Before 1970s, preventing bereaved parents from ... | background { # sec1 } = = = = = = = = = = stillbirth and its consequences have attracted some research interest. however, there still remains an uncertainty particularly about how to advise medical staff of the necessary steps that should be taken around stillbirth bereavement care. before 1970s, preventing bereaved pa... | Background {# Sec1} = = = = = = = = = = Stillbirth and its consequences have attracted some research interest. However, there still remains an uncertainty particularly about how to advise medical staff of the necessary steps that should be taken around stillbirth bereavement care. Before 1970s, preventing bereaved pare... | Background {#Sec1} ========== Stillbirth and its consequences have attracted some research interest. there still remains an uncertainty particularly about how to advise medical staff of the necessary steps that should be taken around stillbirth bereavement care. Before 1970s, preventing bereaved from seeing their infan... | baCkGrOuND {#SeC1}
==========
stiLlBIRTH AND iTs ConsEquEncEs HAvE AtTrACtED SOmE REseArcH INTEREST. hOWeVER, thErE StiLl remaIns An UNCErTaINtY PaRTiCUlARlY ABoUt hoW tO ADviSE MEDIcaL StafF OF the neCeSsARY StePS That sHould BE takeN ARounD STillBirTh BErEAvEmeNt CaRe. BEfORe 1970S, prEveNtiNG BEReavED PArentS From ... | Background {#Sec1}========== Stillbirth and its consequences have attracted some research interest.However, therestill remains an uncertainty particularlyabout how to advisemedical staff of thenecessary steps that should betaken around stillbirth bereavement care. Before 1970s, preventingbereaved parents fro... | _Background_ {#Sec1} _==========_ Stillbirth and its consequences have _attracted_ _some_ research interest. However, _there_ still remains an uncertainty particularly about how to advise medical staff of the necessary steps that should be _taken_ around stillbirth bereavement care. Before 1970s, preventing bereaved _p... |
In the article cited above, the addition of \"^b^\" annotation would be needed in Table 5 of the main text.
^b^In case of CURB-65, the variables are as follows: age \< 65 years, absence of chronic cardiovascular disorder, absence of chronic lung disease, absence of CNS disorders, and absence of chronic renal disorders... | in the article cited above, the addition in \ " ^ b ^ \ " annotation would be needed in table 5 of the main text. ^ b ^ in case of curb - 66, the variables are as follows : age \ < 65 years, absence of chronic cardiovascular issues, absence of terminal lung disease, absence of cns disorders, and absence of chronic rena... | In the article cited above, the addition of \ " ^ b ^ \ " annotation would be needed in Table 5 of the main text. ^ b ^ In case of CURB - 65, the variables are as follows: age \ <65 years, absence of chronic cardiovascular disorder, absence of chronic lung disease, absence of CNS disorders, and absence of cjronjc renal... | the article cited above, the addition of \"^b^\" annotation would be needed in Table 5 of the main ^b^In case of CURB-65, the variables are as follows: age \< 65 years, absence of chronic cardiovascular disorder, absence lung disease, absence of CNS disorders, absence of renal disorders. Hence, meaning of text would ne... | iN the arTiCLE CITEd ABOve, THe ADDiTIon OF \"^B^\" AnnOTATIoN Would bE NEedeD IN TaBLe 5 OF THe maIN tEXT.
^B^in caSe OF cUrB-65, ThE vARIableS aRe aS FOLlOws: age \< 65 yEarS, absENce oF ChRoNIc cardiOVAsCuLar disORDER, AbSeNcE Of chRONic LunG DIsEAse, absEncE OF cns diSOrDErs, and AbsEncE OF CHrONIc rENal dISorDers... | In the article cited above, the addition of \"^b^\" annotation would be needed in Table 5 of the main text. ^b^In case of CURB-65, the variables are as follows: age \< 65 years, absence of chronic cardiovascular disorder, absence ofchronic lung disease, absenceof CNS disorders, and absence... | In the article cited above, _the_ addition _of_ _\"^b^\"_ _annotation_ would be needed _in_ Table 5 of _the_ main text. ^b^In case of CURB-65, the variables are as _follows:_ age \< 65 _years,_ absence of chronic _cardiovascular_ disorder, absence of chronic lung disease, _absence_ of _CNS_ disorders, and absence of _c... |
Introduction {#S1}
============
The adaptive immune system must distinguish between self and non-self in order to provide protection from pathogenic challenges while sparing the organism's own tissues. Recognition of B7 ligands (CD80 and CD86, also known as B7-1 and B7-2, respectively) by co-stimulatory CD28 and co-in... | introduction { # s1 } = = = = = = = = = = = = denotes adaptive immune system must distinguish between self and non - self in order to provide protection from pathogenic challenges while sparing the organism ' s own tissues. recognition of b7 ligands ( cd80 and cd86, also known as b7 - 1 and b7 - 2, respectively ) by co... | Introduction {# S1} = = = = = = = = = = = = The adaptive immune system must distinguish between self and non - self in order to provide protection from pathogenic challenges while sparing the organism ' s own tissues. Recognition of B7 ligands (CD80 and CD86, also known as B7 - 1 and B7 - 2, respectively) by co - stimu... | Introduction {#S1} ============ The adaptive immune system must distinguish between self and non-self in order to provide protection from pathogenic challenges while sparing the organism's own tissues. Recognition of B7 ligands (CD80 and CD86, known as B7-1 B7-2, by co-stimulatory CD28 and co-inhibitory CTLA-4 (cytotox... | InTRODUction {#s1}
============
tHe adaPTiVE iMMUne SYsTeM MUsT dIStINGUisH beTWEen SElf aNd Non-self in orDER TO PrOvIde prOtEcTIon frOM PatHoGEnIc ChaLLeNgEs wHilE sParing The ORgAnIsm'S own TIssUES. RECoGniTioN of b7 Ligands (cd80 anD cD86, ALSo kNoWn aS b7-1 anD b7-2, RespectIVeLy) By CO-STiMUlatory cD28 ANd CO-IN... | Introduction {#S1} ============ The adaptive immune systemmust distinguish between self and non-self in order to provide protection frompathogenic challenges while sparingthe organism's own tissues. Recognition of B7 ligands(CD80 andCD86, also known as B7-1 and B7-2, respectively) by co-stimulatory ... | Introduction {#S1} ============ The adaptive immune system must distinguish between self and _non-self_ in order to provide _protection_ _from_ pathogenic challenges _while_ _sparing_ the organism's own tissues. Recognition _of_ B7 ligands (CD80 and CD86, also _known_ as B7-1 and B7-2, respectively) _by_ _co-stimulator... |
###### Summary box
What is already known about this subject?
=========================================
- The 2019 new coronavirus pneumonia is a new infectious clinical disease caused by a new coronavirus, called SARS-CoV-2.
- Fever and cough were the most common symptoms in patients with COVID-19, but some non-... | # # # # # # summary box what is already known about this subject? = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = - the 2019 new coronavirus pneumonia is a new infectious clinical disease caused by a new coronavirus, called sars - cov - 2. - fever and cough were the most common symptom... | # # # # # # Summary box What is already known about this subject? = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = - The 2019 new coronavirus pneumonia is a new infectious clinical disease caused by a new coronavirus, called SARS - CoV - 2. - Fever and cough were the most common symptom... | ###### Summary box What is already about this subject? ========================================= - The 2019 new coronavirus pneumonia is a new infectious clinical disease by a new coronavirus, called SARS-CoV-2. - Fever and cough were the most common symptoms in patients with COVID-19, but some non-classical symptoms w... | ###### sumMarY Box
wHat is alREady KNoWn ABout THIS SUbJECt?
=========================================
- the 2019 neW coRONaVIrUs PneuMOnIA is a NEW InFeCtIOUs cLINIcal dIseaSE cAUsEd By A NeW cOronAviRUS, CAlLEd SARs-cov-2.
- FEvER AND CoUgh WeRE thE MoSt CoMMON SYMPTOMs in PAtIeNTS wItH coVId-19, bUT SOmE NOn-... | ###### Summary box What is already known about this subject? ========================================= - The 2019 new coronavirus pneumonia is a new infectious clinical disease caused by a new coronavirus, called SARS-CoV-2. - Fever andcough were the most commonsymptoms in patients with COVID-19, ... | ###### Summary box _What_ is already known about this subject? ========================================= - The 2019 new coronavirus pneumonia is a new infectious clinical disease caused by a new coronavirus, called SARS-CoV-2. - _Fever_ and cough were the most common symptoms in patients with _COVID-19,_ but _some_ non... |
Introduction {#s1}
============
Ischemic preconditioning of a limb (IPC) is a non-invasive technique inducing transient peripheral hypoxia to subsequently enhance tissue tolerance against ischemia-reperfusion injury. This technique promotes local vasodilation, improves O~2~ delivery (Enko et al., [@B14]; Bailey et al.... | introduction { # s1 } = = = = = = = = = = = = ischemic preconditioning of a limb ( ipc ) is a non - invasive technique inducing transient peripheral hypoxia to subsequently enhance tissue tolerance against anti - reperfusion injury. this technique promotes muscle vasodilation, improves o ~ 2 ~ usage ( enko et al., [ @ ... | Introduction {# s1} = = = = = = = = = = = = Ischemic preconditioning of a limb (IPC) is a non - invasive technique inducing transient peripheral hypoxia to subsequently enhance tissue tolerance against ischemia - reperfusion injury. This technique promotes local vasodilation, improves O ~ 2 ~ delivery (Enko et al. , [@... | Introduction {#s1} ============ Ischemic of a limb (IPC) is a non-invasive technique inducing transient peripheral hypoxia to subsequently tolerance against ischemia-reperfusion injury. This promotes local vasodilation, O~2~ delivery (Enko et al., [@B14]; Bailey et al., [@B1]), and enhances the efficiency of muscular (... | IntRODUcTIon {#S1}
============
IScheMiC prECONdITiOnING of A Limb (iPC) IS a NON-inVASIVE tECHNiQUe inducIng TRaNsieNt PeRIPhERAl HypoXiA tO SubSeQuEntlY ENhANce tISsUe tOLerAnCE AgaInsT iscHEmia-rEperFUSION INJUry. ThIS TeChNIqUE ProMOTes locaL vAsODiLaTiOn, ImPrOvEs o~2~ DElIvEry (eNko et al., [@B14]; bAIley Et Al.... | Introduction {#s1} ============ Ischemic preconditioning ofa limb (IPC) is a non-invasive technique inducing transient peripheralhypoxia to subsequently enhance tissue toleranceagainst ischemia-reperfusion injury. This technique promotes local vasodilation, improves O~2~ delivery (Enko et a... | Introduction {#s1} ============ Ischemic preconditioning of a limb _(IPC)_ is a non-invasive technique _inducing_ transient peripheral hypoxia to _subsequently_ enhance tissue tolerance against ischemia-reperfusion injury. This technique promotes local vasodilation, _improves_ _O~2~_ _delivery_ _(Enko_ et al., _[@B14];... |
Introduction {#Sec1}
============
Speed-accuracy trade-offs (SATs), such as that between movement speed and spatial accuracy, are one of the most common phenomena in human movement. SATs have been actively studied since Woodworth^[@CR1]^, who measured the accuracy of voluntary movement. Fitts' law, the most famous SAT... | introduction { # sec1 } = = = = = = = = = = = = speed - accuracy trade - offs ( sats ), such about that between movement speed and spatial accuracy, are one of the most common phenomena in human movement. sats not been actively studied since woodworth ^ [ @ cr1 ] ^, who measured the accuracy of voluntary movement. fitt... | Introduction {# Sec1} = = = = = = = = = = = = Speed - accuracy trade - offs (SATs ), such as that between movement speed and spatial accuracy, are one of the most common phenomena in human movement. SATs have been actively studied since Woodworth ^ [@ CR1] ^, who measured the accuracy of voluntary movement. Fitts ' law... | Introduction {#Sec1} ============ Speed-accuracy trade-offs (SATs), such as that between movement speed and spatial accuracy, are one of the most common phenomena in human movement. SATs have been studied since Woodworth^[@CR1]^, who the accuracy of voluntary movement. Fitts' the most famous SAT model, has been widely ... | inTrODUcTioN {#seC1}
============
sPeeD-ACcuRacy TRADe-OFFS (SATS), such AS THAT BETwEEN MoveMenT sPeEd and spatiAl accuraCY, aRe onE OF tHe most ComMON PhENOmeNA IN hUmAn MoVemeNT. Sats Have BEEn acTiVEly StUdiED SINCE WOoDWorTH^[@cr1]^, wHo meaSUrED THE ACCUraCy oF vOLUNTarY mOveMeNT. FITTS' LaW, ThE MoSt fAmoUs sAt... | Introduction {#Sec1} ============ Speed-accuracy trade-offs (SATs), such as that between movement speed and spatial accuracy,areone of the most common phenomena inhuman movement. SATs have been actively studied since Woodworth^[@CR1]^, who measuredthe accuracy of voluntarymovement.Fitts' law, themost f... | Introduction _{#Sec1}_ ============ Speed-accuracy trade-offs (SATs), such as that _between_ movement speed and spatial accuracy, are _one_ of the _most_ common _phenomena_ _in_ human movement. SATs have been actively studied _since_ Woodworth^[@CR1]^, who _measured_ the accuracy of _voluntary_ movement. Fitts' _law,_ ... |
Introduction
============
The radical coupling reaction,[@cit1] wherein the nearly zero activation energy[@cit2] of connecting two distinct odd-electron partners enables a strong tendency to generate a new chemical bond, often furnishes an efficient and direct synthetic pathway to molecules with high functional group ... | introduction = = = = = = = = = = = = the radical coupling reaction, [ @ cit1 ] wherein the nearly zero activation energy [ @ cit2 ] of connecting two distinct odd - electron partners enables a strong tendency to generate a new chemical bond, often furnishes an efficient and direct synthetic pathway to molecules having ... | Introduction = = = = = = = = = = = = The radical coupling reaction, [@ cit1] wherein the nearly zero activation energy [@ cit2] of connecting two distinct odd - electron partners enables a strong tendency to generate a new chemical bond, often furnishes an efficient and direct synthetic pathway to molecules with high f... | Introduction ============ The radical coupling wherein the nearly zero activation of connecting two distinct odd-electron partners enables a strong tendency to generate a new chemical bond, often furnishes an efficient and direct synthetic pathway to molecules with high functional group tolerance. Therefore, the develo... | INTRODuCTioN
============
tHe rADiCAl CoupLInG reactION,[@Cit1] whereiN THe NEArLy zERO aCTivaTiOn enERgy[@Cit2] OF ConneCTInG tWo dISTinCt odD-eleCtrON PARtnERs ENaBlEs a STRONG tENDENCy To gEnERAte A new ChEmicaL Bond, OftEN FuRnIShEs an effiCIeNT aND DiReCt sYNtHetIC PathwaY TO molEcules WiTh hiGH fUnCTiOnAl gROUp ... | Introduction ============ The radical coupling reaction,[@cit1]wherein the nearly zero activation energy[@cit2]of connecting two distinct odd-electron partners enables a strong tendency to generate a newchemical bond,often furnishes an efficient and direct synthetic pathway to molecules with high funct... | Introduction ============ The radical coupling _reaction,[@cit1]_ _wherein_ the nearly zero activation energy[@cit2] of connecting two distinct odd-electron partners enables a _strong_ _tendency_ to generate a new chemical bond, often furnishes an efficient and direct synthetic pathway _to_ molecules with high function... |
Lu N, Lv Q, Sun X, et al. Isoalantolactone restores the sensitivity of gram‐negative *Enterobacteriaceae* carrying MCR‐1 to carbapenems. J Cell Mol Med. 2020;24:2475--2483. 10.1111/jcmm.14936
Lu and Lv contributed equally to this work.
1. INTRODUCTION {#jcmm14936-sec-0001}
===============
Infections caused by multid... | lu n, lv q, sun x, et al. isoalantolactone restores the sensitivity of gram screened negative * enterobacteriaceae * carrying mcr ‐ 1 to carbapenems. j cell mol med. 2020 ; 24 : 2475 - - 2483. 10. 1111 / jcmm. 14936 lu and lv contributed equally to this work. 1. introduction { # jcmm14936 - sec - 0001 } = = = = = = = =... | Lu N, Lv Q, Sun X, et al. Isoalantolactone restores the sensitivity of gram ‐ negative * Enterobacteriaceae * car$yinn MCR ‐ 1 to carbapenems. J Cell Mol Med. 2020; 24: 2475 - - 2483. 10. 1111 / jcmm. 14936 Lu and Lv contributed equally to this work. 1. INTRODUCTION {# jcmm14936 - sec - 0001} = = = = = = = = = = = = = ... | Lu N, Lv Q, Sun X, et al. Isoalantolactone restores sensitivity of gram‐negative *Enterobacteriaceae* carrying to carbapenems. J Cell Mol Med. 2020;24:2475--2483. Lu and Lv contributed equally to this work. 1. INTRODUCTION {#jcmm14936-sec-0001} =============== caused by multidrug‐resistant (MDR) gram‐negative pathogens... | LU N, Lv Q, SUN X, Et AL. IsoalaNTolACtONE rEsTorES THe sENsitIvIty of Gram‐NEgaTIvE *ENtERoBAcTeriacEAe* CARRYINg mCR‐1 to CaRbAPENeMs. j CELl Mol MEd. 2020;24:2475--2483. 10.1111/jCmM.14936
lu AND LV cONTribUted EqUALlY To THIS woRk.
1. inTROductION {#jCMM14936-sEC-0001}
===============
INFectiONs CAUsed BY MUlTId... | Lu N, Lv Q, SunX, et al.Isoalantolactone restores thesensitivity of gram‐negative *Enterobacteriaceae* carrying MCR‐1 to carbapenems. JCell Mol Med. 2020;24:2475--2483. 10.1111/jcmm.14936Lu and Lv contributed equally to this work. 1. INTRODUCTION {#jcmm14936-sec-0001}===============Infectionscaused ... | Lu N, Lv _Q,_ Sun _X,_ et _al._ Isoalantolactone restores the sensitivity of gram‐negative *Enterobacteriaceae* _carrying_ MCR‐1 to _carbapenems._ _J_ Cell Mol Med. 2020;24:2475--2483. 10.1111/jcmm.14936 Lu and Lv contributed equally _to_ this work. 1. INTRODUCTION {#jcmm14936-sec-0001} =============== Infections cause... |
Cold storage has been the method of choice for liver preservation for \<50 years now. Hypothermia effectively protects the organ by reduced metabolism for distinct periods. However, the organ is exposed to hypoxic, hypoenergetic, and hyponutritional conditions. These are nonfunctional in the cold but unmasked upon repe... | cold storage has been the method of choice for liver preservation for \ < 50 years now. hypothermia effectively protects the organ by reduced metabolism for distinct periods. however, the organ is exposed to hypoxic, hypoenergetic, and hyponutritional conditions. these are nonfunctional in the cold but unmasked upon re... | Cold storage has been the method of choice for liver preservation for \ <50 years now. Hypothermia effectively protects the organ by reduced metabolism for distinct periods. However, the organ is exposed to hypoxic, hypoenergetic, and hyponutritional conditions. These are nonfunctional in the cold but unmasked upon rep... | Cold storage has been the method choice for liver preservation for \<50 years now. Hypothermia effectively protects the organ by reduced metabolism for distinct periods. However, the organ is exposed to hypoxic, hypoenergetic, hyponutritional These are nonfunctional in the cold but unmasked upon reperfusion trigger cel... | cOlD StOrAge hAs beeN ThE MetHOD Of ChoIcE FOR LIVER PReServATiON for \<50 yEarS Now. HYpOTHERMIa efFeCtiVEly PRoTectS tHE oRGAN BY reduCEd MetAbOLISM For DistINCT peRioDs. HOWevEr, ThE oRgan IS eXpoSed To HypoXIC, hYPoenerGETIC, anD hypoNUtRItIONaL conDITIONS. THese aRe nONFUnCtIONaL IN thE colD BUt unmASKeD UpOn REPE... | Coldstorage has been the method of choice for liver preservation for \<50years now. Hypothermia effectivelyprotects the organ by reduced metabolismfor distinct periods. However, the organ isexposed to hypoxic, hypoenergetic, and hyponutritional conditions. These arenonfunctionalinthecold but unmasked upon rep... | Cold storage has been _the_ method of choice for liver preservation _for_ \<50 years now. Hypothermia effectively protects _the_ organ by reduced metabolism for _distinct_ _periods._ However, _the_ organ _is_ _exposed_ to hypoxic, hypoenergetic, and hyponutritional conditions. _These_ are nonfunctional in _the_ cold _b... |
INTRODUCTION
============
Idiopathic ventricular tachycardia (VT), which develops without any cardiac abnormalities, can be divided into four types: outflow tract VT, verapamil sensitive fascicular VT, focal Purkinje VT and annular VT. The main mechanism of idiopathic left VT is reentry that passes through anterior or... | introduction = = = = = = = = = = = = idiopathic ventricular tachycardia ( vt ), which develops without any cardiac abnormalities, can be divided into four types : outflow tract vt, verapamil sensitive fascicular vt, focal purkinje vt and annular vt. the main mechanism of developing left vt is reentry that passes throug... | INTRODUCTION = = = = = = = = = = = = Idiopathic ventricular tachycardia (VT ), which develops without any cardiac abnormalities, can be divided into four types: outflow tract VT, verapamil sensitive fascicular VT, focal Purkinje VT and annular VT. The main mechanism of idiopathic left VT is reentry that passes through ... | ============ Idiopathic ventricular tachycardia (VT), which develops without any cardiac abnormalities, can be divided into four types: outflow tract VT, verapamil sensitive fascicular VT, focal VT and VT. The main mechanism of idiopathic left VT is reentry that through anterior or fascicle.[@B1],[@B2] This fascicular ... | INtrodUCTION
============
IDiOpAThiC veNTRICulaR tACHYcARDIa (VT), whiCH DEveLOpS withOUt aNy carDiaC abNoRMALItieS, CAn Be DiVIDed InTO FouR TyPes: oUTfLow tRacT Vt, VerapaMiL SensItive fAScICUlar vT, fOcal PURKinjE Vt AND aNNULaR vt. THe MaIn meCHAnism oF IDIopAtHIc lEFt Vt Is REENTRy ThAT PAsseS thrOUGh antERiOr oR... | INTRODUCTION ============Idiopathic ventriculartachycardia (VT), which developswithout any cardiac abnormalities, canbe divided into fourtypes: outflow tract VT,verapamil sensitive fascicular VT, focal Purkinje VT and annular VT.Themain mechanism of idiopathic left VT is reentry that passes throughant... | INTRODUCTION ============ _Idiopathic_ ventricular tachycardia (VT), _which_ develops without any cardiac abnormalities, can be _divided_ into four types: outflow tract VT, verapamil sensitive _fascicular_ _VT,_ _focal_ Purkinje VT and annular VT. _The_ main _mechanism_ of idiopathic left VT _is_ reentry that _passes_ ... |
Introduction {#s1}
============
*Mycobacterium tuberculosis* (*Mtb*) is responsible for the greatest number of deaths by a bacterial pathogen worldwide [@pone.0058378-World1]. *Mtb* can produce progressive disease or latent infection [@pone.0058378-Parrish1]; indeed, in high endemic areas, infection first occurs in ch... | introduction { # s1 } = = = = = = = = = = = = * mycobacterium tuberculosis * ( * mtb * ) is responsible for the greatest number of deaths by a bacterial pathogen worldwide [ @ pone. 0058378 - world1 ]. * mtb * can produce progressive disease or latent infection [ @ ts. 0058378 - parrish1 ] ; indeed, in high endemic are... | Introduction {# s1} = = = = = = = = = = = = * Mycobacterium tuberculosis * (* Mtb *) is responsible for the greatest number of deaths by a bacterial pathogen worldwide [@ pone. 0058378 - World1 ]. * Mtb * can produce progressive disease or latent infection [@ pone. 0058378 - Parrish1 ]; indeed, in high endemic areas, i... | Introduction {#s1} ============ *Mycobacterium tuberculosis* (*Mtb*) is responsible for the greatest number deaths by a bacterial [@pone.0058378-World1]. *Mtb* can produce progressive disease or latent infection [@pone.0058378-Parrish1]; in high endemic areas, infection first occurs in childhood and is in most cases. O... | iNtroDuCtIon {#S1}
============
*mYCoBacTErium tUBERcUloSIs* (*MTb*) IS ReSpoNsibLe FOR tHE GREATEsT NUMBEr Of DEATHS By A bActeRiaL PatHoGEN WoRldWIde [@PONe.0058378-wOrld1]. *MTb* caN PrOduCE PROGresSivE dISeaSe or LatEnT InFecTioN [@pONe.0058378-paRRiSh1]; iNdEED, IN high endEmIC AREAs, iNfeCTiON fIrSt oCcURS iN CH... | Introduction {#s1} ============*Mycobacterium tuberculosis* (*Mtb*) is responsible for thegreatest number ofdeaths by a bacterial pathogen worldwide [@pone.0058378-World1]. *Mtb* can produce progressive disease or latent infection [@pone.0058378-Parrish1]; indeed, inhigh endemic areas,infectionfirst oc... | _Introduction_ _{#s1}_ ============ *Mycobacterium tuberculosis* (*Mtb*) is responsible for the greatest number of deaths _by_ a _bacterial_ pathogen worldwide [@pone.0058378-World1]. *Mtb* can produce _progressive_ disease or latent _infection_ [@pone.0058378-Parrish1]; indeed, in high endemic areas, _infection_ _firs... |
Introduction {#Sec1}
============
Therapies for metastatic advanced thyroid cancers are inadequate with most therapeutic approaches failing to produce meaningful long-term responses (Smallridge et al. [@CR27]; Licitra et al. [@CR16]). The relatively modest response rates with tyrosine kinase inhibitors (TKIs) have led... | introduction { # sec1 } = = = = = = = = = = = = therapies for metastatic advanced thyroid cancers are inadequate with most therapeutic approaches failing to produce meaningful long - term responses ( smallridge et al. [ @ cr27 ] ; licitra et al. [ @ cr16 ] ). the relatively modest response rates with tyrosine kinase in... | Introduction {# Sec1} = = = = = = = = = = = = Therapies for metastatic advanced thyroid cancers are inaCeqKate with most therapeutic approaches failing to produce meaningful long - term responses (Smallridge et al. [@ CR27 ]; Licitra et al. [@ CR16] ). The relatively modest response rates with tyrosine kinase inhibitor... | {#Sec1} ============ Therapies for metastatic advanced thyroid cancers are inadequate with most therapeutic approaches failing to produce long-term responses (Smallridge et al. [@CR27]; Licitra et al. [@CR16]). The relatively modest response rates tyrosine kinase inhibitors (TKIs) have led to several ongoing trials usi... | InTRODUctIOn {#sEC1}
============
thERApiES FoR MeTastATIc ADvanCED tHYroiD CANCERS ARE inaDEquate WitH MOsT theRAPeuTIC appROACHEs fAILiNG TO pROdUCE meaNingFul loNG-tERM ResPONSEs (sMalLriDge ET Al. [@CR27]; liciTRa et Al. [@cR16]). THe reLatIvELy MOdEST RespoNse RAtEs WiTH tYRoSine kiNaSe InhibitoRs (TkIS) HaVE leD... | Introduction {#Sec1} ============ Therapies for metastatic advanced thyroid cancers are inadequate with most therapeutic approachesfailing to produce meaningful long-term responses (Smallridgeet al. [@CR27]; Licitra et al. [@CR16]).The relatively modest response rates with tyrosine kinase inhibitors (TKIs)... | Introduction {#Sec1} ============ Therapies for metastatic advanced _thyroid_ cancers _are_ inadequate with most _therapeutic_ approaches _failing_ to produce meaningful long-term responses (Smallridge et al. [@CR27]; Licitra _et_ _al._ [@CR16]). The relatively modest _response_ _rates_ _with_ _tyrosine_ kinase inhibit... |
1. Introduction {#sec1}
===============
Adenosine 3′,5′-cyclic monophosphate (cAMP) is an ubiquitous second messenger which directly activates protein kinase A (PKA) and EPACs (exchange proteins directly activated by cAMP) and opens cyclic nucleotide-gated channels \[[@B1], [@B2]\]. PKA is the primary downstream effec... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = adenosine 3 ′, 5 ′ - cyclic monophosphate ( camp ) is an ubiquitous second messenger which directly activates protein kinase a ( pka ) and epacs ( exchange proteins directly activated by camp ) and opens upstream nucleotide - gated channels \ [ [ @ b1 ], [ @ b2 ]... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = Adenosine 3 ′, 5 ′ - cyclic monophosphate (cAMP) is an ubiquitous second messenger which directly activates protein kinase A (PKA) and EPACs (exchange proteins directly activated by cAMP) and opens cyclic nucleotide - gated channels \ [[ @ B1 ], [@ B2] \ ]. PKA is ... | 1. Introduction {#sec1} =============== Adenosine 3′,5′-cyclic monophosphate (cAMP) is an ubiquitous second messenger which directly activates protein kinase A (PKA) and (exchange proteins directly activated by cAMP) and opens cyclic nucleotide-gated channels \[[@B1], [@B2]\]. PKA the primary downstream effector of cAM... | 1. inTroducTIOn {#SEc1}
===============
adENoSINe 3′,5′-cyclIc mOnOPHospHAtE (cAmp) is aN UbIQuITOUs SECOnd MessENgEr whIch dIrECtLy aCtivATes pRoTEin KINase a (PkA) And epACs (ExCHangE PRotEINS DirEcTLY ACtiVatED by CAmp) And OPEns CyCLic nucLeOtIDe-Gated chANnEls \[[@b1], [@b2]\]. PKa is tHe PRiMary DownsTrEAm eFfEc... | 1. Introduction {#sec1} =============== Adenosine3′,5′-cyclic monophosphate (cAMP)is an ubiquitous second messenger which directly activates protein kinase A (PKA) and EPACs (exchange proteins directly activated by cAMP) andopens cyclicnucleotide-gated channels \[[@B1],[@B2]\]. PKA is the primary downstream ef... | 1. _Introduction_ {#sec1} =============== Adenosine 3′,5′-cyclic monophosphate _(cAMP)_ is an ubiquitous _second_ messenger which directly activates protein kinase A (PKA) _and_ EPACs (exchange proteins _directly_ _activated_ by cAMP) and opens cyclic nucleotide-gated channels \[[@B1], [@B2]\]. _PKA_ is the primary dow... |
LETTERS TO EDITORS
==================
We found the recent original article published in the Korean Journal of Pain by Seung Yeup Han et al., entitled \"The effect of low-dose ketamine on post-caesarean delivery analgesia after spinal anesthesia\" \[[@B1]\]. The authors expertly detailed an interesting investigation ab... | letters to editors = = = = = = = = = = = = = = = = = = we found the recent original article published in the korean journal of pain by seung yeup han et co., entitled \ " the effect of low - dose ketamine on post - caesarean delivery analgesia after spinal anesthesia \ " \ [ [ @ b1 ] \ ]. the authors expertly detailed ... | LETTERS TO EDITORS = = = = = = = = = = = = = = = = = = We found the recent original article published in the Korean Journal of Pain by Seung Yeup Han et al. , entitled \ " The effect of low - dose ketaHjne on post - caesarean delivery analgesia after spinal anesthesia \ " \ [[ @ B1] \ ]. The authors expertly detailed a... | LETTERS TO EDITORS ================== We found the recent original article published in the Journal of Pain by Seung Yeup Han et al., entitled \"The effect of low-dose ketamine on post-caesarean delivery analgesia after spinal anesthesia\" \[[@B1]\]. The authors expertly detailed an interesting investigation about the ... | LeTterS to EdiTors
==================
We fOuND tHe ReCeNT orIGinal aRtIcle PUbLishED iN tHe KorEaN journaL Of Pain by sEunG YEup hAn eT Al., EnTItlED \"the EFfeCT oF LOW-doSE kEtAmINe oN posT-CaESarEan DeLiVERY ANalgesiA aftEr SPINAL anESThESiA\" \[[@b1]\]. the auThors EXpERtlY DEtaIlED AN IntErEstINg inVeSTiGAtIoN aB... | LETTERS TO EDITORS ================== We found the recent original articlepublished in the Korean Journalof Pain by Seung Yeup Hanet al., entitled \"The effect of low-dose ketamine onpost-caesarean delivery analgesia after spinal anesthesia\"\[[@B1]\]. Theauthors expertly detailed an interesting investiga... | LETTERS TO _EDITORS_ ================== _We_ found _the_ recent original _article_ _published_ in the Korean Journal of Pain by Seung _Yeup_ Han et al., entitled \"The effect of low-dose ketamine on _post-caesarean_ delivery _analgesia_ after _spinal_ _anesthesia\"_ \[[@B1]\]. _The_ authors _expertly_ detailed an inter... |
Introduction
============
In the last two decades there have been progresses in understanding thyroid carcinoma histogenesis and biology. Papillary thyroid carcinomas (PTC) represents 80% of thyroid malignancies and is characterized by slow growth and an excellent prognosis \[[@B1]\]. Patients with PTC have the best s... | introduction = = = = = = = = = = = = in the last two decades there have been progresses in understanding thyroid carcinoma histogenesis and biology. papillary thyroid carcinomas ( ptc ) represents 80 % of thyroid malignancies and is characterized by slow growth and an excellent prognosis \ [ [ @ b1 ] \ ]. patients with... | Introduction = = = = = = = = = = = = In the last two decades there have been progresses in understanding thyroid carcinoma histogenesis and biology. Papillary thyroid carcinomas (PTC) represents 80% of thyroid malignancies and is characterized by slow growth and an excellent prognosis \ [[ @ B1] \ ]. Patients with PTC ... | Introduction ============ In the last two decades there have been progresses in understanding thyroid carcinoma histogenesis and biology. Papillary thyroid carcinomas (PTC) represents 80% of thyroid malignancies and is characterized by slow growth and an excellent prognosis \[[@B1]\]. Patients with PTC have the best su... | INtRodUCTiON
============
in thE LasT twO dECadES ThERe HAVe been progReSSEs in understaNDInG THyroiD carCINOMA HisTOGeneSis anD bIOLOGY. PApilLAry THyrOId CarcInOMas (ptC) repReSEnTS 80% OF ThyroID maLiGNAncies ANd Is ChARACtERIzEd by SLOW grOwth aND An EXCellenT PrOGNosis \[[@B1]\]. patiEnTs WITh pTC HAve THE BeST S... | Introduction ============ In the last two decades there have been progresses in understandingthyroid carcinoma histogenesis and biology. Papillary thyroid carcinomas (PTC)represents 80% of thyroidmalignancies and is characterized by slow growth and an excellent prognosis \[[@B1]\].Patients... | Introduction ============ In the last two decades there have _been_ progresses in understanding thyroid carcinoma histogenesis _and_ biology. Papillary thyroid carcinomas (PTC) _represents_ _80%_ _of_ thyroid malignancies and is characterized by slow growth and an excellent _prognosis_ \[[@B1]\]. Patients with PTC _hav... |
1. Introduction {#sec1-ijerph-15-02367}
===============
It is estimated that around 15% of schoolchildren have a chronic health issue \[[@B1-ijerph-15-02367],[@B2-ijerph-15-02367]\] and that, due to these problems, they can present some degree of inhibition for full integration in their school activities, giving rise ... | 1. introduction { # sec1 - ijerph - 15 - 02367 } = = = = = = = = = = = = = = = it is estimated that approximately 15 % of schoolchildren have a chronic health issue \ [ [ @ b1 - ijerph - 15 - 02367 ], [ @ b2 - ijerph - 15 - 02367 ] \ ] and that, related to these problems, they can present some degree of inhibition for ... | 1. Introduction {# sec1 - ijerph - 15 - 02367} = = = = = = = = = = = = = = = It is estimated that around 15% of schoolchildren have a chronic health issue \ [[ @ B1 - ijerph - 15 - 02367 ], [@ B2 - ijerph - 15 - 02367] \] and that, due to these problems, they can present some degree of inhibition for full integration i... | 1. Introduction {#sec1-ijerph-15-02367} =============== It is estimated that around 15% of schoolchildren have a chronic health issue \[[@B1-ijerph-15-02367],[@B2-ijerph-15-02367]\] and that, problems, can present some degree of inhibition for full integration in their school activities, giving rise to behavioral probl... | 1. IntrOductIon {#SEC1-iJeRph-15-02367}
===============
iT IS estImATed thaT aRoUNd 15% Of schooLCHILDrEn Have A cHRONIC HEaltH IsSUe \[[@b1-ijErph-15-02367],[@B2-IJErPh-15-02367]\] and That, duE to TheSE probLEms, THeY CAn PRESeNt sOmE deGRee Of inHIBitiOn fOr FUlL IntEGRATIOn in tHEir SCHoOl acTiviTIes, gIvInG RISE ... | 1.Introduction{#sec1-ijerph-15-02367} =============== It is estimated thataround 15% of schoolchildren have a chronic health issue \[[@B1-ijerph-15-02367],[@B2-ijerph-15-02367]\]and that, due to these problems, they can presentsome degree of inhibition forfull integration in theirschool activities,... | 1. Introduction _{#sec1-ijerph-15-02367}_ =============== It _is_ _estimated_ that around 15% of _schoolchildren_ _have_ a chronic health issue \[[@B1-ijerph-15-02367],[@B2-ijerph-15-02367]\] _and_ that, due to _these_ problems, they can present some _degree_ of inhibition for full _integration_ in their school activit... |
1. Introduction {#sec0005}
===============
Peste des Petits Ruminants (PPR) is a viral disease of sheep and goats associated with high morbidity and mortality in affected flocks and found in large parts of Africa and Asia ([@bib0015]). In 2015, FAO and OIE launched a Global Control and Eradication Strategy for PPR whi... | 1. introduction { # sec0005 } = = = = = = = = = = = = = = = peste des petits ruminants ( ppr ) is a viral disease of sheep and goats associated with high morbidity and mortality in affected flocks and found in large parts of africa and asia ( [ @ 2500 ] ). in 2015, fao and oie launched a global control and eradication ... | 1. Introduction {# sec0005} = = = = = = = = = = = = = = = Peste des Petits Ruminants (PPR) is a viral disease of sheep and goats associated with high morbidity and mortality in affected flocks and found in large parts of Africa and Asia ([ @ bib0015] ). In 2015, FAO and OIE launched a Global Control and Eradication Str... | 1. Introduction {#sec0005} =============== Peste des Petits Ruminants (PPR) is a viral disease of sheep and goats associated with high morbidity and in affected flocks and found in large parts of Africa and Asia ([@bib0015]). In 2015, FAO and OIE launched a Global Control and Eradication for PPR which utilises a progre... | 1. INTRodUCtion {#sec0005}
===============
pesTE DES PEtiTs rumINanTS (PPr) IS a viRaL diSEAse of shEeP AND gOATs aSSOciAteD wItH hIGh mORbIDITY aND MorTaLity iN aFfECTED FlOCKS AND found In laRgE PaRts of afrIca AND aSiA ([@bib0015]). iN 2015, Fao AnD oIe launcHED A GlOBAl contrOL And eRADiCatIOn StRaTeGy FOr Ppr wHi... | 1. Introduction{#sec0005} =============== Pestedes Petits Ruminants (PPR) isa viral disease of sheep and goats associated with high morbidityand mortality inaffected flocks andfound in largepartsof AfricaandAsia ([@bib0015]).In 2015, FAO and OIE launched a Global Control and Eradication Strategy forPPRwh... | 1. Introduction {#sec0005} _===============_ Peste des Petits Ruminants _(PPR)_ is a viral disease of sheep _and_ _goats_ associated with high _morbidity_ _and_ mortality in affected flocks and found _in_ _large_ parts of _Africa_ and _Asia_ ([@bib0015]). In 2015, FAO and OIE launched a Global Control and Eradication S... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Mobile games are very diverse, and each game has its own characteristics. The games that players become extremely passionate about have some key attractive features. These games induce different emotions a... | all relevant data are within the paper and its supporting information files. introduction { # sec001 } = = = = = = = = = = = = mobile games are very diverse, and each game has its own characteristics. competitive games that players become extremely passionate about have some key attractive features. these games induce ... | All relevant data are within the paper and its Supporting Information files. Kntrpduction {# sec001} = = = = = = = = = = = = Mobile games are very diverse, and each game has its own characteristics. The games that players become extremely passionate about have so,# key attractive features. These games induce different ... | All relevant are within and its Supporting Information files. Introduction {#sec001} ============ Mobile games are very diverse, and each game has its characteristics. The games that players become extremely passionate about have some key attractive features. These games induce different emotions sensory in order to ke... | ALL RElevaNT DATa Are WiTHIN thE paper anD ItS sUpPoRTInG iNfOrmAtIOn FiLEs.
iNtrodUcTIOn {#seC001}
============
mObiLe GameS aRE Very dIVErSe, AnD EaCh gamE HAS itS oWn CHarACTEriStIcs. THE GamEs tHat PLAYERS BeComE extremELy PasSioNATe abOUt Have somE kEy aTtrACTivE fEAtUREs. THESe Games iNducE DiFFErENT EMoTionS a... | All relevant data are within the paper and its Supporting Information files. Introduction {#sec001}============ Mobile games are verydiverse, and each game has its own characteristics. The games that players becomeextremely passionate about have some keyattractive features. These games induce diff... | All relevant data are within the _paper_ _and_ its Supporting _Information_ files. Introduction {#sec001} ============ Mobile games _are_ _very_ _diverse,_ _and_ _each_ game has its own characteristics. The _games_ that players become _extremely_ passionate about have some key attractive features. These games induce di... |
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research a... | the content published in cureus is usually result of clinical experience and / or research by independent individuals or organizations. cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. article content published within cureus is intended only for educational, ... | The content published in Cureus is the result of clinical experience and / or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research... | The content published in Cureus result of clinical experience and/or research by independent or organizations. Cureus is not responsible the scientific accuracy or of data or conclusions published herein. within Cureus is only for educational, research and reference purposes. Additionally, articles published within Cur... | THe coNTeNt PubliShed iN cuREUS is the ReSULT OF cliNicaL eXPErIence ANd/oR REsEaRcH by INdEpenDeNt indIVidUaLs Or ORGaniZatIOns. CuReUs IS not RESpONSiBle For THe SCIEnTifIC aCcuRAcy Or REliabILitY of DaTA oR ConcluSIONS pUBlIShEd hereIn. aLl cOntenT puBlisHED WITHin CUreUs Is iNtENDeD only fOR edUCATIoNaL, ReSEaRCh A... | The content published inCureus is the result of clinicalexperience and/or research by independent individuals or organizations. Cureus isnot responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educati... | The content published in Cureus is the result _of_ clinical experience _and/or_ research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability _of_ data or conclusions published herein. _All_ _content_ published _within_ _Cureus_ is intended only for education... |
\"Our poor family seems persecuted by this awful disease, the worst I know.\" Queen Victoria (1819-1901) of the United Kingdom of Great Britain and Ireland wrote in her diary. She is well known as the most famous carrier of hemophilia, the \"royal disease\", and had passed on the disease to several royal families in Eu... | \ " our poor family seems persecuted by this awful disease, the worst i know. \ " queen victoria ( 1819 - 1901 ) of the united kingdom of great britain and ireland wrote in her diary. she is well known as the most famous carrier of hemophilia, the \ " royal disease \ ", and had passed on the disease to several royal fa... | \ " Our poor family seems persecuted by this awful disease, the worst I know. \ " Queen Victoria (1819 - 1901) of the United Kingdom of Great Britain and Ireland wrote in her diary. She is well known as the most famous carrier of hemophilia, the \ " royal disease \ ", and had passed on the disease to several royal fami... | \"Our poor family seems persecuted by this awful disease, the worst I know.\" Queen (1819-1901) the United Kingdom of Great and Ireland wrote in diary. She is well known as the most famous carrier of hemophilia, the disease\", and had passed on the disease to several royal families in Europe through her daughters. Sinc... | \"oUr Poor famILY SeEms peRSeCuted BY thiS AWFUL diSEasE, THe worST I KNOW.\" QUEEn viCtoria (1819-1901) OF The uNitEd kIngdom of gREAt brITaiN ANd iRELANd WRote iN HeR dIarY. SHE is WeLL Known AS ThE mOst FaMous CarRIEr Of hemOPhIlIa, tHe \"ROYAl DISeaSe\", and Had PaSsEd ON tHe DisEASe to sEveraL royal fAMiliES in Eu... | \"Our poor family seems persecuted by thisawful disease, the worst I know.\" Queen Victoria (1819-1901) of the United Kingdom of Great Britain and Ireland wrote in her diary. She is well known as the most famous carrier of hemophilia, the \"royal disease\", and had passed on the disease to several ro... | \"Our poor _family_ seems persecuted by this awful disease, the worst I know.\" Queen Victoria (1819-1901) of the United _Kingdom_ of Great Britain and _Ireland_ wrote in her _diary._ She _is_ well known as the _most_ famous carrier of hemophilia, the \"royal disease\", and had _passed_ on the _disease_ to _several_ ro... |
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Correction
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After publication of this article \[[@B1]\], we noticed that the acknowledgement of our funding source was not sufficiently specific. We hereby acknowledge that this research was supported in part by the Food and Drug Administration Office of Women\'s Health, USA.
| text = = = = 4 - - - - - - - - - - after publication of this article \ [ [ @ b1 ] \ ], we concluded that the knowledge of our funding source was not sufficiently satisfactory. we hereby note that this research assistance supported through part by un food and rural administration office of women \ ' s health, usa. | TDxH = = = = Correction - - - - - - - - - - After publication of this arY&cle \ [[ @ B1] \ ], we noticed tua% the acknowledgement of our funding source was not sufficiently specific. We hereby acknowledge tjah tYOs research was WupporHed in part by the FloV and er*g Administration Office of WImRn \ ' s Hea/tM, USA. | Text ==== Correction ---------- publication of this article \[[@B1]\], we noticed that the acknowledgement of our funding source was not sufficiently specific. hereby acknowledge that this research was supported part by the and Drug Administration Office of Women\'s Health, USA. | text
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CORrecTiON
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aFTER pUbLIcaTioN of tHis aRTicle \[[@b1]\], WE NotICed thaT THE ACkNoWlEDGEmeNT OF OUr fuNDiNg soURCe WAs noT suFfIcIeNTLy sPECiFIc. WE herEBY AcknOwleDGe THat THIS rEsEaRcH WAs SUPPOrtED In paRT BY The fooD and DruG adMinISTRAtIoN OfFIce Of WomeN\'s HeALTh, USA.
| Text ==== Correction ---------- Afterpublication of this article \[[@B1]\], we noticed that the acknowledgementof our funding source was not sufficientlyspecific. We herebyacknowledge thatthis research was supported in part by the Food and Drug Administration Office of Women\'s Health, USA. | Text ==== Correction ---------- After publication of this _article_ \[[@B1]\], we _noticed_ that the acknowledgement of _our_ funding source _was_ _not_ sufficiently specific. We hereby acknowledge that this _research_ _was_ supported in part by _the_ Food and _Drug_ Administration Office of _Women\'s_ _Health,_ USA. |
######
Comparison of the cost of antiretroviral treatment, by manufacturer and region
Manufacturer ARV (dose) No. of Sub-Saharan Africa countries (no. of individual transactions) Sub-Saharan Africa median cost per person per year (IQR), US\$ No. of Non-Africa countries (no. of individual transact... | # # # # # # comparison of the cost of antiretroviral treatment, by manufacturer and region manufacturer arv ( dose ) no. of sub - saharan africa or ( no. of individual transactions ) sub - saharan africa median priced in person per year ( iqr ), us \ $ no. of non - africa countries ( no. of individual transactions ) no... | # # # # # # Comparison of the cost of antiretroviral treatment, by manufacturer and r$g8on Manufacturer ARV (doE$) No. of Sub - SsUaran Africa countries (no. of individual transactions) Sub - Saharan Africa median Vos6 per perXoJ per year (IQR ), US \ $ No. of Non - Africa countries (no. of individual transactions) Non... | ###### Comparison of the cost of treatment, by manufacturer and region Manufacturer ARV (dose) No. of Sub-Saharan Africa countries of individual transactions) Sub-Saharan Africa median per person per year (IQR), US\$ No. of Non-Africa countries of individual transactions) Non-Africa median cost per person per year (IQR... | ######
ComPARison of tHe COst OF aNtIretrOViRal TREaTmENt, By ManUFACtUrER And reGIoN
maNuFactuRer aRv (DOse) No. oF SuB-SAharAn aFricA CoUNTries (no. oF inDivIdual TRaNSActions) sub-sAhARAN AfrICA medIaN cost PER pERSon Per YeAR (iQr), us\$ nO. OF NON-AfriCa COUNtries (NO. OF IndiviDUAl TRanSACT... | ###### Comparison of thecost of antiretroviral treatment,by manufacturer and region Manufacturer ARV (dose) No. ofSub-Saharan Africa countries (no. of individual transactions) Sub-Saharan Africamedian cost per person per year (IQR), US\$ No. of Non-Africa countries (no. of individual transactions) Non-Africame... | ###### Comparison of the cost of antiretroviral treatment, by manufacturer and region Manufacturer ARV _(dose)_ No. of _Sub-Saharan_ _Africa_ countries (no. of individual _transactions)_ Sub-Saharan Africa median _cost_ per person per year _(IQR),_ _US\$_ No. of Non-Africa countries _(no._ of individual transactions) N... |
Related literature {#sec1}
==================
For a related structure, see: Yamin *et al.* (2011[@bb6]). For standard bond lengths, see: Allen *et al.* (1987[@bb1]).
Experimental {#sec2}
============
{#sec2.1}
### Crystal data {#sec2.1.1}
C~11~H~12~ClFN~2~OS*M* *~r~* = 274.75Monoclinic,*a* = 14.818 (7) Å*b* = 10.... | related literature { # sec1 } = = = = = = = = = = = = = = = = = = for a related structure, see : yamin * et al. * ( 2011 [ @ bb6 ] ). for standard bond lengths, see : allen * et al. * ( 1987 [ @ bb1 ] ). text { # sec2 } = = = = = = = = = = = = { # sec2. 1 } # # # crystal data { # sec2. 1. 1 } c ~ 11 ~ h ~ 12 ~ clfn ~ 2... | Related literature {# sec1} = = = = = = = = = = = = = = = = = = For a related structure, see: Yamin * et al. * (2011 [@ bb6] ). For standard bond lengths, see: Allen * et al. * (1987 [@ bb1] ). Experimental {# sec2} = = = = = = = = = = = = {# sec2. 1} # # # Crystal data {# sec2. 1. 1} C ~ 11 ~ H ~ 12 ~ ClFN ~ 2 ~ OS * ... | Related literature {#sec1} For a structure, see: *et al.* (2011[@bb6]). For standard bond lengths, see: Allen *et al.* (1987[@bb1]). Experimental {#sec2} ============ {#sec2.1} Crystal data {#sec2.1.1} C~11~H~12~ClFN~2~OS*M* = = 14.818 (7) Å*b* = (5) Å*c* = 18.201 (9) Åβ = 112.599 (12)°*V* = 2562 (2) Å^3^*Z* = 8Mo *K*α... | RElaTed lITeRATURe {#SEc1}
==================
foR A rELaTED STRUCtuRe, See: YAmIN *Et aL.* (2011[@BB6]). FOR STaNDarD boNd LeNGthS, SEE: AlLEN *Et aL.* (1987[@bb1]).
eXPErimentAL {#sec2}
============
{#SEc2.1}
### cRYStAl DATa {#Sec2.1.1}
c~11~h~12~cLfn~2~os*M* *~R~* = 274.75MOnocLINic,*A* = 14.818 (7) Å*B* = 10.... | Related literature {#sec1} ================== For a related structure, see: Yamin *et al.* (2011[@bb6]). For standard bond lengths,see: Allen *et al.* (1987[@bb1]). Experimental {#sec2} ============ {#sec2.1} ### Crystaldata {#sec2.1.1} C~11~H~12~ClFN~2~OS*M* *~r~* = 274.75Monoclinic,*a* = 14.818 ... | _Related_ _literature_ {#sec1} ================== For _a_ related structure, see: Yamin *et _al.*_ _(2011[@bb6])._ For standard _bond_ _lengths,_ _see:_ _Allen_ *et al.* (1987[@bb1]). Experimental {#sec2} ============ {#sec2.1} _###_ Crystal data {#sec2.1.1} C~11~H~12~ClFN~2~OS*M* _*~r~*_ = 274.75Monoclinic,*a* = 14.81... |
Introduction {#sec1-1}
============
Previous reports have clearly documented that aortic stiffness is associated not only with coronary artery disease (CAD) but also with cardiovascular risk factors, such as hypercholesterolemia, smoking, older age, hypertension, impaired glucose tolerance and diabetes mellitus (DM), ... | introduction { # sec1 - 1 } = = = = = = = = = = = = previous reports have clearly documented that aortic stiffness is associated not only with coronary artery disease ( cad ) but also with cardiovascular risk factors, such as hypercholesterolemia, smoking, older age, hypertension, impaired glucose tolerance and diabete... | Introduction {# sec1 - 1} = = = = = = = = = = = = Previous reports have clearly documented that aortic stiffness is asqociat@d not only with coronary artery disease (CAD) but also with cardiovascular risk factors, such as hypercholesterolemia, smoking, older age, hypertension, impaired glucose tolerance and diabetes me... | Introduction {#sec1-1} ============ Previous reports have clearly documented that aortic stiffness is associated not only with coronary artery disease (CAD) but with cardiovascular risk factors, such as hypercholesterolemia, smoking, older age, hypertension, impaired glucose tolerance and diabetes mellitus (DM), and ob... | iNTrodUcTIOn {#SeC1-1}
============
PrEviOUS rEPoRts HAVE CLeARLy DOCUMeNtED THat AoRTic STIFFneSS is aSsociatED NOt oNlY wiTh cORONaRY aRtErY DIsEasE (cad) buT AlsO witH CArdiOvAsCULAr RisK FactORS, such as HypERCholESTERoLemiA, SmokiNg, oLder AGe, hYPeRTension, ImPAireD gluCOsE tOLERAnCe ANd diaBEteS meLLItus (dM), ... | Introduction {#sec1-1} ============ Previous reports have clearly documented that aortic stiffness is associatednot only with coronary artery disease (CAD) but also withcardiovascular riskfactors, such as hypercholesterolemia, smoking, older age, hypertension, impaired glucosetolerance and diabetesmellitu... | Introduction {#sec1-1} _============_ Previous reports _have_ clearly documented that aortic _stiffness_ is associated _not_ only with coronary artery disease (CAD) but also with cardiovascular risk factors, such as _hypercholesterolemia,_ smoking, older age, hypertension, impaired glucose tolerance and _diabetes_ mell... |
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