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Background
==========
Gonorrhoea is a major public health concern globally \[[@B1]\]. In 2011, 39 179 gonorrhoea cases were reported from 28 European Union (EU)/European Economic Area (EEA) Member States, with an overall incidence of 12.6 cases per 100,000 population \[[@B2]\]. In most of the non-EU/EEA countries of t... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-17-02262}
===============
Industrial inspection has to date been an exclusively human task. However, maintaining a group of people detecting surface defects accelerates visual fatigue and misinterpretations. Automatic visual inspection allows for detection of defects by image analysis. T... | {
"pile_set_name": "PubMed Central"
} |
(J Am Heart Assoc. 2015;4:e002626 doi: [10.1161/JAHA.115.002626](10.1161/JAHA.115.002626))
Introduction {#jah31237-sec-0004}
============
Cardiac resynchronization therapy (CRT) is an effective treatment for patients with systolic heart failure and electrical dyssynchrony, resulting in improvements in both symptoms a... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-materials-10-01138}
===============
Scandium is classified along with yttrium and other lanthanides as a rare-earth (RE) element, has an atomic number of 21, an atomic weight of 44.96, and is the 31st most abundant element in the earth's crust, exhibiting a Clarke number of 22 ppm \[[@B1-materia... | {
"pile_set_name": "PubMed Central"
} |
Preradiosurgical embolization of cerebral arteriovenous malformations (AVMs) has been warranted as a signif icant treatment to eliminate the risk of hemorrhage during the latency period after radiosurgical treatment, and to achieve AVM volume reduction to a size amenable to radiosurgical treatment, resulting in earlier... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Peroneal tendon (PT) disorders are common causes of lateral and retromalleolar ankle pain \[[@B1]--[@B3]\]. PT injuries include tenosynovitis, chronic tendinopathy, subluxation and dislocation, longitudinal splits, partial or complete tears, and painful os peroneum syndrome \[[@... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Eye drops account for \~90% of ophthalmic drug delivery systems available ([@b1-etm-0-0-5586]). Traditional eye drops are usually lost from the ocular surface by tear washing or nasolacrimal drainage immediately after administration, with poor ocular bioavailability and numerous adverse react... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
BNP7787 (Tavocept, disodium 2,2′-dithio-*bis*-ethanesulfonate) is an investigational agent that is a novel, water-soluble disulfide that has been evaluated in Phase II and Phase III clinical trials in patients with advanced non-small-cell lung cancer (NSCLC).[@b1-ott-8-375] The American Cance... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Brain tumors are the second most common form of childhood cancer, after acute lymphoblastic leukemia (ALL) \[[@B1]\]. Treatment for both brain tumors and ALL includes cranial RT. Given 5-year survival rates that approach 90% for children treated for ALL and 70% for those treated... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Endometrial cancer is the third most common gynecologic cancer, and its incidence and mortality are increasing in Korea, where more than 1,700 new cases are diagnosed and approximately 250 deaths occur every year from the disease \[[@B1][@B2]\]. The incidence rate increases every year by 6.9%... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
In cancer research, high-throughput profiling has been extensively conducted, searching for genomic signatures with predictive power for traits or clinical outcomes. In this article, we analyze cancer prognosis studies, where the clinical outcomes are metastasis-free, overall, or other types of s... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
In athletics and rehabilitation, functional capacity can be evaluated through different methods; one of them is the vertical jump test. In addition, the vertical jump serves as a predictor of anaerobic capacity, motor development and athletic ability in sports \[[@ref1]-[@ref7]\]. Other studi... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Maternal mortality remains unacceptably high across much of the developing world. An estimated 358, 000 maternal deaths occurred worldwide in 2008. Sub-Saharan Africa (SSA) and South Asia accounted for 87% of the global maternal deaths \[[@B1]\]. In sub-Saharan Africa, a woman's risk of dying fro... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1_115}
============
Heavy metal pollutions are particularly hazardous contaminants in food and the environment. In general, they are not biodegradable and have long biological half-lives. According to the World Health Organization (World Health Organization [@CR21_115]) heavy metals must be controlle... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Phytopathogenic bacteria cause serious economic losses by reducing the yield of marketable quality crops \[[@pone.0181499.ref001]\]. *Ralstonia solanacearum*, which causes vascular wilt disease, is one of ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-25-01442}
===============
Genus *Gentiana* is one of the largest groups in Gentianaceae, comprising 360 species that are widespread across Northwest of Africa, Europe, America, East of Australia, and Asia \[[@B1-molecules-25-01442]\]. Many species of this genus have significant economi... | {
"pile_set_name": "PubMed Central"
} |
The authors wish to make the following corrections to this paper:(1)The work described in this paper encompasses part of the European Intelligent Cooperative Sensing for Improved (ICSI) traffic efficiency project. The authors, as partners of the project, want to clarify that its main contribution, which is the central ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Persistently opened sclerotomies after 23-gauge pars plana vitrectomy (PPV) represent a small percentage of the surgical complications associated with the procedure. However, some studies have reported the need for sclerotomy sutures at the end of the surgery after functional testing... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Autoimmune diseases reflect the interplay between environment and genetic factors ([@B1]--[@B3]). The diseases share a substantial degree of immunopathology, including increased secretion of inflammatory cytokines by autoreactive CD4^+^ T cells and a loss of Regulatory T cells (Tregs) f... | {
"pile_set_name": "PubMed Central"
} |
Abbreviations, acronyms & symbols
----------------------------------- ---------------------------------------
BP = Blood pressure
CABG = Coronary artery bypass grafting
CPB = Cardiopulmonary bypass
CTA ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Early debut of sexual activity is associated with greater risk of HIV and other sexually transmitted diseases (STDs) as well as unwanted pregnancy among teens in the United States. While the prevalence of sexual intercourse and pregnancy among teens has declined significantly in the United States... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Macrolide antibiotics were shown to have immunomodulatory and anti-inflammatory, as well as antibacterial effects (Culic et al. [@b13]; Martinez et al. [@b28]; Kanoh and Rubin [@b23]). In vitro azithromycin inhibits the release of the neutrophil chemoattractant interleukin(IL)-8 and of granul... | {
"pile_set_name": "PubMed Central"
} |
ANNOUNCEMENT {#s1}
============
A healthy human feces sample was preenriched in modified peptone yeast (PY) medium ([@B1]) under anaerobic conditions at 37°C for 5 days. After 3 consecutive dilutions, 0.1 ml of the sample (10**^−^**^3^ dilution) was plated on anaerobic agar ([@B2]) and incubated anaerobically at 37°C ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The concept of case management is thought to be an effective and efficient approach to manage patients with chronic illness and complex health care needs \[[@B1]\]. Case management can implement key elements of the chronic care model, such as improved continuity of care by redesigning the deliver... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Proton pump inhibitors (PPIs) are a class of pharmacological agents used to treat acid-related disorders, such as gastroesophageal reflux disease, erosive esophagitis and peptic ulcer.[@CIT0001] Examples of PPI include omeprazole, pantoprazole and esomeprazole, which rank among the t... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
In 2013, there were over 3 million breast cancer survivors in the USA, and with a 5-year relative survival rate of 89.7%, this number will continue to increase \[[@CR1]\]. However, survivors often encounter physiological and psychological problems that may influence long-term prognosis, s... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Tobacco production and consumption have risen dramatically in the developing world \[[@B1]\]. While smoking rates have declined in high-income countries, the public health burden of tobacco is shifting towards the developing world, where by 2030 more than 80% of the world\'s tob... | {
"pile_set_name": "PubMed Central"
} |
GENOME ANNOUNCEMENT {#h0.0}
===================
In the marine environment, the [d]{.smallcaps}-amino acids synthesized by microbes can be released into the seawater ([@B1]). [d]{.smallcaps}-Amino acids ([d]{.smallcaps}-AAs), as the α-carbon enantiomers of [l]{.smallcaps}-amino acids ([l]{.smallcaps}-AAs), are commonly... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Aqueous lithium-air batteries have been considered as a promising electrochemical energy storage system for electric vehicles. The theoretical energy density for the cell reaction of 4Li + 6H~2~O + O~2~ = 4(LiOH·H~2~O) is 1910 Wh·kg^−1^, which is significantly higher than 387 Wh·kg^−1^ ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Heart failure (HF) is a complex clinical syndrome and is often caused by reduced cardiac pump function, affecting approximately 1--2% of people in the Western world^[@CR1]^. The most prevalent cause of HF is an acute myocardial infarction (MI). Despite the significant reduction of ear... | {
"pile_set_name": "PubMed Central"
} |
The views expressed in this Commentary do not necessarily reflect the views of this journal or of ASM.
COMMENTARY {#h0.0}
==========
The remarkable achievements made by filariasis control programs testify to the success possible with focused effort and investment in tropical health interventions. Human infections wit... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .94}
| {
"pile_set_name": "PubMed Central"
} |
Background
==========
Extralobar pulmonary sequestration is a congenital anomaly resulting in the formation of ectopic lung tissue outside the normal lung with its own pleural investment, but no communication with the normal tracheobronchial tree. Without associated malformations, symptomatic cases are rare, and are u... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer death in the United States. In 2010, approximately 142,000 people were diagnosed with CRC, and about 40% of these patients presented with advanced disease [@pone.0038422-Mnejja1]. Treatment fo... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-16-00419}
===============
Polarization-maintaining fiber (PMF) is a crucial component of integrated optical sensors and fiber-optic interferometers \[[@B1-sensors-16-00419],[@B2-sensors-16-00419]\]. Called polarization mode coupling (PMC), the optical power coupling between two orthogona... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
Gene expression is often regulated by transcription factors (TFs). TFs bind to specific DNA-binding sites and modulate the expression of genes. Therefore, to understand transcriptional regulations, gi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
Nitrobenzene (\"nitrobenzol\" or \"oil/essence of mirbane\") is a pale yellow aromatic nitro compound frequently used in synthetic rubber, dye and paint industries \[[@bib0005]\]. It is a potent oxidizer of the iron moiety of haemoglobin causing methaemoglobinemia leading to ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Nucleotide sequences diverge over time due to the combined effects of point mutation and homologous recombination. Recombination events cause changes to regions of contiguous bases in single events and were generally assumed to be rare in bacteria. However, there is growing evidence that homo... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
Optic neuritis (ON) is an inflammation of the optic nerve and has various causes such as demyelinating, infective, vasculitis, sarcoidosis, toxic, metabolic, and hereditary neuropathy.
Most commonly it is a demyelinating inflammation of the optic nerve and typically, initially occu... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Claudins are a family of tight junctional proteins which are highly expressed in both benign and malignant ovarian tumors \[[@b1-ijms-14-10412]\]. Normal epithelial cells are held together by tight junctions (TJs), adherens junctions (AJs), and gap junctions. TJs are the apical cell-cel... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Apc loss causes progenitor expansion in development and disease
---------------------------------------------------------------
The Wnt/ß-catenin signaling pathway acts to maintain the undifferentiated progenitor state in multiple epithelial tissues, and overactivation of this pathway is a major... | {
"pile_set_name": "PubMed Central"
} |
Findings
========
NPC is a distinct type of head and neck cancer which is consistently associated with Epstein-Barr virus (EBV). Detection of clonal EBV genome in both precancerous lesions and invasive cancers indicates that EBV latent infection is an early event in the tumorigenesis of NPC. Since we established the E... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Psychosis is a complex brain disorder that typically emerges in late adolescence or early adulthood ^[@R1]^, enormously impacts functioning, and results in large costs to public health ^[@R2]^. There are significant brain abnormalities in psychosis, including progressive brain tissue lo... | {
"pile_set_name": "PubMed Central"
} |
The authors wish to make the following correction to their paper \[[@B1-antioxidants-09-00508]\]:
The number corresponding to the affiliation of Lucian Hritcu had been changed from:
**Lucian Hritcu ^1,^\***
to
**Lucian Hritcu ^2,^\***
The authors would like to apologize for any inconvenience caused to the readers ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
There are two forms of sphingosine kinase (SphK), SphK1 and SphK2. SphK1 has an established role in malignant biology with overexpression being associated with poor survival in patients with solid tumors \[[@CR1]--[@CR10]\] and resistance to therapy \[[@CR11]--[@CR14]\]. Furthermore, inhi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Spinal cord injury (SCI) usually causes unreversible motor and sensory impairments. The incidence of SCI is 40 to 80 new cases per million people per year from all causes, depending on the country. For traumatic SCI, the ratio of male-to-female is around 2 : 1 \[[@B1]\]. SCI res... | {
"pile_set_name": "PubMed Central"
} |
All original data from this study have been uploaded to Figshare, and can be found using the following links: Study 1: <https://doi.org/10.6084/m9.figshare.5692852>; Study 2: <https://doi.org/10.6084/m9.figshare.5692933>.
Introduction {#sec001}
============
In quiet standing the ankles play a crucial role in connecti... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Chronic hepatitis C virus (HCV) infection, with a worldwide prevalence of 2%-3% \[[@CR1]\], causes substantial loss of life and reduces quality of life in those who are infected \[[@CR2]\]. Although the screening of blood products has reduced the incidence of HCV infection in developed co... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Focal epilepsies, in which the seizures originate from a region limited to a part of one cerebral hemisphere ([@B1]), are common and account for more than 50% of all epilepsies ([@B2]). Despite the great improvement in pharmacological research, approximately 30% of patients with focal e... | {
"pile_set_name": "PubMed Central"
} |
This study funded by AHRQ examines the implementation and scale-up of Lean methodology for enhancing value in a large, ambulatory care delivery system. While evidence indicates that Lean techniques can lead to higher quality care at lower cost, its success or failure is inextricably tied to the views and activities of ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Exercise practice is a non-pharmacological treatment for a series of diseases \[[@CR1]\]. Along with dietary control, appropriate exercise programs are proposed to treat and attenuate obesity \[[@CR2]\] and its associated cardiovascular disorders such as hypertension \[[@CR3]\]. It is kno... | {
"pile_set_name": "PubMed Central"
} |
Biopolymers are polymers that are biodegradable. The input materials for the production of these polymers may be either renewable (based on agricultural plant or animal products) or synthetic. Current and future developments in biodegradable polymers and renewable input materials focus relate mainly to the scaling-up o... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .4}
{#sp2 .5}
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"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Epidemiology studies from mainland China spanning 2000--2014 have shown that the prevalence of hyperuricemia is 13.7% in urban Chinese and 12.3% in rural Chinese individuals (Liu et al., [@B11]). Hyperuricemia causes gouty arthritis (Zamudio-Cuevas et al., [@B34]), kidney stones (Mirhey... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The exponential increase in data traffic requires high-capacity optical links. A fast, compact, energy-efficient, broadband optical modulator is a vital part of such a system. Modulators integrated with silicon (Si) or silicon nitride (SiN) platforms are especially promising, as they ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Stroke is the leading cause of death and permanent disability in adults worldwide, especially in low-and middle-income countries, with important clinical and socio-economic implications.[@CIT0001] Among them, ischemic stroke accounts for about 87% of stroke cases.[@CIT0002] In the ac... | {
"pile_set_name": "PubMed Central"
} |
Although laparoscopic treatment for appendicitis has been documented as a feasible and safe alternative to conventional open appendectomy with minimal complications and short hospital stay,[@b1-asm-2-100],[@b2-asm-2-100] there remains skepticism in the surgical community with respect to its increased technical difficul... | {
"pile_set_name": "PubMed Central"
} |
Background {#s1}
==========
As the Covid-19 pandemic evolves, acute care surgeons, intensivists and other surgical specialists increasingly may be asked to perform a tracheostomy in patients with known or suspected coronavirus-19 infection. Practitioners must be prepared for this inevitability while taking measures to... | {
"pile_set_name": "PubMed Central"
} |
Morelli F, Benedetti Y, Møller AP, Fuller RA. Measuring avian specialization. Ecol Evol. 2019;9:8378--8386. 10.1002/ece3.5419
**Data Availability Statement:** The datasets generated during and/or analyzed during the current study is provided in the Appendix.
1. INTRODUCTION {#ece35419-sec-0001}
===============
Measu... | {
"pile_set_name": "PubMed Central"
} |
A 78-year-old man with a history of type 2 diabetes mellitus and arterial hypertension presented to the emergency department with right groin pain and fever. Just two days before, he had undergone laparoscopic transperitoneal inguinal hernia repair (TAPP) of a right-sided indirect inguinal hernia with fixation of mesh.... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-20-00193}
===============
Metformin is a biguande class compound that is the most widely prescribed and well-tolerated drug for type II diabetes. In recent years, it has also received attention as a potential anticancer agent. A retrospective study done by Evan et. al. was the first to show... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
NOTCH proteins are trans-membrane receptors that transduce signals from cell-bound JAGGED (JAG) and Delta-like (DLL) families of ligands to mediate cell-cell interactions in processes as diverse as fetal development, heart disease and cancer^[@CR1],[@CR2]^. Upon interaction with ligan... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Oligodendrocytes are myelin-producing cells of the CNS (central nervous system) essential for the health and proper function of neural circuitry. Alterations in oligodendrocyte numbers and in myelination are associated with a number of neurological and psychiatric disorders that include multi... | {
"pile_set_name": "PubMed Central"
} |
{.958}
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{.960}
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"pile_set_name": "PubMed Central"
} |
Introduction
============
Medical therapy is the initial treatment option for the vast majority of cases of the open angle glaucomas. The use of the topical medications exposes the patient to the side effects of the active components of the drops as well as those of the preservatives. Monotherapy with a single drop is... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .600}
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![](edinbme... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
The family of 14-3-3 proteins plays a pivotal role in integrating cellular survival signaling and thereby are key players in determining the cell fate \[[@R1], [@R2]\]. Through their role in binding multiple phospho-client proteins within the cell, 14-3-3 proteins regulate many importan... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Due to rapid changes in climate and demography, vector-transmitted arboviral diseases pose an increasing threat to global health and welfare [@ppat.1004319-Mackenzie1]--[@ppat.1004319-Wilson1]. Among the most severe arboviral infections known to affect the human race are those caused by... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s0005}
============
Kupffer cells (KCs), the resident tissue macrophages of the liver have a crucial role in both the pathogenesis and the resolution of various liver diseases and inflammatory states including alcohol-induced liver injury [@b0005], non-alcoholic fatty liver disease associated with obesi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Recently, an increasing number of patients with critical limb ischemia (CLI) have been undergoing medical care at clinical practice sites. Improving the outcome of treatment for these patients is an important and urgent issue. Since 2013, the Japanese Society for Vascular Surgery (JSVS)... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Cellular compartmentalization is a hallmark of eukaryotic cells and transport between compartments is required to maintain cellular homeostasis and energy production^[@CR1]^. This cellular organization is based on the interaction between actin filaments, microtubules and intermediate ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Livestock farming is considered a major contributor to anthropogenic methane (CH~4~) emissions, which is mainly attributed to ruminants \[[@CR1]\]. Methane production is also energetically wasteful for ruminants resulting in a loss of 2--12% of the ingested feed energy \[[@CR2]\]. Several... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Alzheimer\'s disease (AD) is an age-related progressive neurodegenerative disorder that causes impairments in memory and thinking. The strongest genetic risk factor for AD is apolipoprotein E (*APOE*) genotype \[[@B1]\]. In comparison to people who are homozygous for the common ε3 allele, people ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Breast cancer (BC) is the most common cancer in women and the 5-year survival rate in Europe is 82% suggesting a considerable residual risk \[[@CR1]\]. BC is associated also with other chronic conditions including type two diabetes which may increase the risk of BC recurrence \[[@CR2]--[@... | {
"pile_set_name": "PubMed Central"
} |
[Fig. 5](#F5){ref-type="fig"} inadvertently appeared in black and white. The correct color version appears below.
{#F5}
| {
"pile_set_name": "PubMed Central"
} |
DNA double-strand break (DSB) repair is critical for chromosomal maintenance. There are several proposed pathways for homology-directed DSB repair including single-strand annealing, synthesis-dependent strand annealing, break-induced replication and Holliday junction pathways[@b1]. All recombinational DSB repair pathwa... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Among the different forms of endometrial cancer, endometrioid endometrial adenocarcinoma (EEA) is the most common type (85%) ([@b1-ol-0-0-10504]). Although the prognosis of EEA is good, extensive heterogeneity has been reported in a number of studies, particularly in patients with an early st... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .34}
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"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
MicroRNAs are small, single-stranded RNAs that have been highly conserved during evolution and function by repressing target gene expression. miRNAs have recently emerged as critical modulators of gene expression networks in mammals, and their impaired expression or function has been li... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Sepsis is a major health challenge. Despite improved treatment options, sepsis remains a leading cause of death in intensive care units \[[@B1]\]. Lipopolysaccharide (LPS), or endotoxin, the major outer membrane component of gram-negative bacteria, is a potent inflammatory response stimulator \[[... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Worm infection, particularly helminthiasis is one of the most common chronic infections of humans. Worldwide more than 200 million people harbor these infections.\[[@ref1]\] It is major global health problem mainly in tropical countries. These infections are common risk factor to co... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-18-01711}
===============
The burden of major depressive disorders (MDD) and schizophrenia (SCZ) is on the rise globally, reflecting ongoing population aging and demographic growth. In 2015, ≈300 million people were affected by MDD; this corresponds to 4.4% of the global population and an i... | {
"pile_set_name": "PubMed Central"
} |
Sabidi S, Koh SP, Abd Shukor S, Adzni Sharifudin S, Sew YS. Safety assessment of fermented jackfruit (*Artocarpus heterophyllus*) pulp and leaves in Sprague‐Dawley rats. Food Sci Nutr. 2020;8:4370--4378. 10.1002/fsn3.1734
1. INTRODUCTION {#fsn31734-sec-0001}
===============
The increase of health awareness due to cha... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-nanomaterials-06-00144}
===============
The depletion of fossil fuels and the effects of global warming and pollution caused by their combustion is a major challenge of modern societies. In recent times, hydrogen (H~2~) production and storage has been investigated as a potential renewable energy... | {
"pile_set_name": "PubMed Central"
} |
Findings {#Sec1}
========
Background {#Sec2}
----------
*Angiostrongylus vasorum* (Baillet, 1866) Kamensky, 1905, is a protostrongylidae parasite nematode of domestic dogs and wild canids, which causes angiostrongylosis, disease important in public health. In this aspect, stands out the presence of free larvae in the... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-20-01174}
===============
Chemerin, a novel adipokine highly expressed in the white adipose tissue, is associated with inflammation and adipogenesis, and also known as retinoic acid receptor responder protein 2 (*RARRES2*) \[[@B1-ijms-20-01174],[@B2-ijms-20-01174],[@B3-ijms-20-01174],[@B4-i... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
In 2016, there were approximately 36.7 million people living with HIV (PLHIV), 1.8 million new HIV infections, and 1 million AIDS-related deaths \[[@CR1]\]. In 2014, the Joint United Nations Programme on HIV/AIDS (UNAIDS) established the 90-90-90 goals for the HIV care cascade. The HIV ca... | {
"pile_set_name": "PubMed Central"
} |
The first author's name is incorrect in the citation. The first author in the citation should be Nordlund LM. The correct citation is: Nordlund LM, Koch EW, Barbier EB, Creed JC (2016) Seagrass Ecosystem Services and Their Variability across Genera and Geographical Regions. PLoS ONE 11(10): e0163091. doi:[10.1371/journ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Comorbid depression in patients with type 2 diabetes (DM2) and/ or coronary heart disease (CHD) is a major health issue. The risk of depression in these patients is approximately double compared to the general population \[[@CR1], [@CR2]\]. This comorbidity is associated with diminished s... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The increasing incidence of skin cancer is a global trend. Skin cancer, which was previously known to be a common disease in Western countries, is occurring more frequently in South Korea. According to the Korean Statistical Information Service[^1^](#fn0001){ref-type="fn"}, the number o... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Renal cell carcinoma (RCC) is the most common malignancy of the kidneys, with clear cell (ccRCC) subtype identified in 85% of these cases; one-third of these patients experience synchronous metastatic disease and 20--30% of the remaining patients have metachronous metastatic RCC \[[@b1-amjcaserep... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
The resting-state network (RSN) is a term referring to functional networks of brain regions that are active when an individual is not focused on the outside world. The RSN is characterized by coherent oscillations at a rate lower than 0.1 Hz among brain regions. Generally, the default mode ne... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
Splenic cystic lesions are uncommon entity with an incidence rate of 0.07% reported in a review of 42,327 autopsies \[[@bib0005]\]. They are classified into true and false cysts based on the presence of cellular epithelial lining \[[@bib0010]\].True or primary cysts are epith... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Articular cartilage injury is increasing in incidence year by year, which is an important healthcare problem. Cell-based tissue engineering holds promise for restoring cartilage defects ([@b1-etm-0-0-4474]). To date, the most widely used cell sources in cartilage regeneration are mesenchymal ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Despite the advances in medical care, bacterial infections remain very common in patients with liver cirrhosis and account for significant morbidity and mortality in them \[[@b1-cm-91-356],[@b2-cm-91-356]\]. Infections are more frequent in patients with decompensated cirrhosis than in those w... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Exercise therapy has long been considered a promising strategy to ameliorate physical disability after stroke (Saposnik et al., [@B58]). However, neurological outcomes of post-stroke rehabilitation appear to differ according to the intensity of the exercise regimen that is used (Bell et... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Hepatitis C virus (HCV) is a major cause of chronic liver disease that can potentially progress to cirrhosis and hepatocellular carcinoma (HCC) \[[@CR1]--[@CR3]\]. It has been estimated that about 130 million to 150 million people worldwide have HCV infection and that HCV causes about 500... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The non-ambiguous perceptual organization of planar visual images into figure and ground requires the visual system to be able to generate a three-dimensional (3D) representation from a two-dimensional (2D) stimulus input. During viewing of a natural 3D scene, objects that are closer to the v... | {
"pile_set_name": "PubMed Central"
} |
This article is part of the Thematic Series \"Organic free radical chemistry\".
Introduction
============
Radical-trapping (chain-breaking) antioxidants are arguably the most important class of compounds used to protect organic materials from oxidative degradation from autoxidation ([Scheme 1](#C1){ref-type="fig"}) \... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .609}
| {
"pile_set_name": "PubMed Central"
} |
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