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"pile_set_name": "PubMed Central"
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Introduction
============
Primary Sjögren\'s syndrome (pSS) is a systemic autoimmune disease with a population prevalence of approximately 0.5% \[[@B1]\]. The lymphoid infiltrates within the inflamed tissues contain ectopic germinal center-like structures in 20% of patients \[[@B2]\]. These structures consist of T- an... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
In Iran, cancers are considered as the third cause of mortality with cardiovascular diseases and accidents are the first cause. The mortality from myocardial infarction in patients with and without diabetes is high in Iran.\[[@ref1][@ref2]\] Pattern of cancer incidence is different ... | {
"pile_set_name": "PubMed Central"
} |
Premature labor is the major contributor to perinatal mortality and morbidity, with an average rate of 10%-12% in developing and developed countries and accounts for 75%-85% of all neonatal deaths. Preterm labor is defined as delivery occurring before 37 completed weeks of gestation ([@R1],[@R2]). A sensitive method to... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .412}
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"pile_set_name": "PubMed Central"
} |
Introduction
============
Rates of cardiovascular disease (CVD) mortality have decreased in recent years due to a combination of prevention and treatment efforts. Following lifestyle recommendations and meeting standard metrics of cardiovascular health can improve CVD risk factors and decreases CVD‐related mortality r... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction {#s1}
============
The development of neuroscience in the last century and in recent years has been very influential in many fields of knowledge such as economics, politics, law, philosophy, public relations, art, etc. Reciprocally, different disciplines of knowledge have also influenced the development o... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#SEC1}
============
The protein structure-function paradigm is a cornerstone of molecular biology, offering a mechanistic understanding of processes ranging from enzyme catalysis, signal transduction to molecular recognition and allosteric regulation. Underlying this paradigm is the assumption that prote... | {
"pile_set_name": "PubMed Central"
} |
Dengue, a mosquito-borne virus prevalent throughout the tropics and subtropics, infects an estimated 390 million people every year ([@r1]). While the majority of infections are mild or asymptomatic, the more severe forms of dengue infection---dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF)---can result i... | {
"pile_set_name": "PubMed Central"
} |
A 35-year-old woman came to our hospital on November 22, 2010, after the onset of unilateral blurred vision and scotomata, purpuric rash over bilateral lower limbs, and metrorrhagia for four days. She had visited Vietnam for 11 days and fever, chills, and headache subsequently developed one day after returning to Japan... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Globally, the number of episodes of clinical pneumonia in young children decreased by 22% from 178 million in 2000 to 138 million in 2015. Yet in the same year, India, Nigeria, Indonesia, Pakistan, and China contributed to more than 54% of all global pneumonia cases, with 32% of the globa... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Glaucoma is one of the leading causes of blindness with over 70 million people affected worldwide and projected to be 80 million by 2020 ([@B1]). It is as an optic neuropathy characterized by cupping of the optic disk, thinning of the retinal nerve fiber layer, and visual field loss ([@... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies against a variety of self antigens. Kidney involvement is a major concern in SLE and is blamed for a large degree of morbidity and mortality in patients. Unfortunately, the clinical management of nephritis b... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Psoriatic arthritis (PsA) is an immune-mediated inflammatory disease with a wide range of clinical manifestations: synovitis, enthesitis, spondylitis, dactylitis, skin, and nail psoriasis. More rarely, it involves the eye (uveitis) and the bowel (Crohn\'s disease). PsA is included in th... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
Epilepsy is a prevalent neurological disorder characterised by the recurrence of spontaneous seizures. Seizures predominantly arise amidst a backdrop of otherwise healthy brain activity and are often accompanied by salient changes in electrographic activity as measured, for exa... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Human inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a multifactorial and debilitating disease characterized by chronic immune-pathology, disruption of intestinal homeostasis, and altered composition of the gut microbiome (dysbiosis). Several lines ... | {
"pile_set_name": "PubMed Central"
} |
{
"pile_set_name": "PubMed Central"
} | |
Cancer Sci 108 (2017) 1065--1070
**Funding Information**
This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labour and Welfare of Japan.
Colorectal cancer has high incidence and mortality worldwide.[1](#cas13217-bib-0001){ref-type="re... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Endothelial cell damage, probably mediated by polymorphonuclear cells (PMN) and PR3-ANCA, plays the main role in the pathogenesis of Wegener\'s granulomatosis (WG). Elevated soluble thrombomodulin (sTM) is an accepted marker of endothelial damage \[[@B1]\]. Factors reflecting endothelial cell... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Acute corneal edema could be due to a myriad of conditions such as angle closure glaucoma, post-intraocular surgery and trauma \[[@B1]\]. Chemical trauma is very common especially in children with increased risk of vision compromise \[[@B2]\]. Chemical injury derives its bad reputation from i... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .328}
| {
"pile_set_name": "PubMed Central"
} |
Background
==========
Coats\' disease is a non-hereditary ocular disease, with no systemic manifestation, first described by Coats in 1908\[[@B1]\]. It occurs more commonly in children and has a clear male predominance (69%) \[[@B2]\]. Most patients present clinically with unilateral decreased vision, strabismus or le... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the United States, affecting an estimated 10 to 20 percent of infants and young children^[@CR1],\ [@CR2]^. Recent studies suggest that the skin may be an important site for systemic sensitization to allerge... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-jcm-07-00090}
===============
The main forms of treatment for malignant neoplasms are chemotherapy and radiotherapy, which often cause various side effects such as oral mucositis (OM) \[[@B1-jcm-07-00090],[@B2-jcm-07-00090],[@B3-jcm-07-00090],[@B4-jcm-07-00090],[@B5-jcm-07-00090],[@B6-jcm-07-000... | {
"pile_set_name": "PubMed Central"
} |
Background and Significance {#Sec1}
===========================
The Human Resources and Services Administration (HRSA) funded Health Center program provides comprehensive, primary care services for more than 22 million patients, many of whom are un or underinsured and from medically underserved populations. Health Cen... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
\[2\] Over the past 15 years, significant new details of the global-scale morphology of the positive ionospheric storm have been revealed by new imaging techniques. The positive storm is a regional-scale condition of the ionosphere occurring during geomagnetic disturbances during which ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Biliary cystadenomas are a family of rare cystic neoplasms of the biliary ductal system. Comprised of two subvariants---serous (more common) and mucinous (less common)---these tumors are considered benign but premalignant. Biliary mucinous cystadenomas (BMCA) account for less than 5% of... | {
"pile_set_name": "PubMed Central"
} |
######
Supplementary appendix: members of STOP GAP trial team
######
Click here for additional data file.
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Supplementary figure: measurement of pyoderma gangrenosum ulcer using image analysis software
######
Click here for additional data file.
Introduction
============
Pyoderma gangrenosum is a rare... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Community-acquired pneumonia (CAP) is one of the most common infection-associated diseases, and is a major cause of hospitalization and death. In particular, older persons are particularly susceptible to CAP and pneumonia-related complications \[[@CR1]\]. Thus, improvements to the quality... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
Ataxia-telangiectasia (A-T) is an inherited neurodegenerative disorder arising from inactivating mutations in *ATM*, a gene encoding a protein kinase regarded as a key regulator of the DNA damage response (DDR) to double-strand breaks (DSBs) [@bib0005; @bib0010; @bib0015]. Co... | {
"pile_set_name": "PubMed Central"
} |
Background {#sec1-0300060520936972}
==========
Myelolipoma was first reported by the pathologist Edgar von Gierke in 1905.^[@bibr1-0300060520936972]^ It is usually a nonfunctioning benign tumor that is incidentally detected in the adrenal gland during routine computed tomography (CT). The occurrence of myelolipoma in ... | {
"pile_set_name": "PubMed Central"
} |
The structure and functions of bacterial membranes are of vital importance to maintain bacterial homeostasis, especially for Gram-negative bacteria. The accessorial and impermeable outer membrane, consisting of a dominant component (LPS), protects bacteria from antibacterial insults.
TARGETING LPS IS UNIQUE FOR GRAM-N... | {
"pile_set_name": "PubMed Central"
} |
[^1]: **Session:** 238. Diagnostics - Pharyngitis
*Saturday, October 7, 2017: 12:30 PM*
| {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Semiconductor quantum dots (QDs) exhibit tunable atomic-like electronic states^[@CR1]^. For this reason, QDs are referred to as artificial atoms and may serve as hosts for spin quantum bits (qubits), the main building block for spin-based quantum computation^[@CR2]^. One of the core p... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Development of cloning and expression technologies to produce recombinant proteins in prokaryotic and eukaryotic organisms enabled the production of numerous enzymes for diagnostic and industrial applications such as food, leather, textile or detergent industry (Kirk et al. [@B25]; Rai and Pa... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .271}
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"pile_set_name": "PubMed Central"
} |
In 1892, the Irish addiction specialist Conolly Norman penned 'A Note on Cocainism' for the *Journal of Mental Science*. Norman began his article with a warning: '\[Though\] a comparatively new drug \[...\] cocaine is more seductive than morphia; it fastens upon its victim more rapidly, and its hold is at least as tigh... | {
"pile_set_name": "PubMed Central"
} |
Alcohol is a risk factor for leading causes of mortality and morbidity among young people. Globally, the harmful use of alcohol accounts for 2.5 million deaths (4% of total), and 69.4 million (4.5% of total) disability-adjusted life years (DALYs) ([@CIT0001], [@CIT0002]). In the 15--29 age group, 9% of total deaths are... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Globally, the human immunodeficiency virus (HIV) infection and its accompanying sequelae, the acquired immune deficiency syndrome (AIDS), account for over 35 million deaths since the first reported cases in 1983 \[[@B1]\]. Infection with human immunodeficiency virus (HIV) impact... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Although progress has been made in the diagnostics and treatment for chronic lymphocytic leukemia (CLL), this type of neoplasm remains incurable, similarly to other types of cancer at an advanced stage. The primary problem faced by hematologists in the treatment of CLL is the coexistence of q... | {
"pile_set_name": "PubMed Central"
} |
Artemisinin, a sesquiterpene lactone isolated from the Chinese herb *Artemisia annua* L., has profound activity against malaria.^[@bib1]^ Artemisinin contains an endoperoxide moiety that reacts with iron to produce toxic reactive oxygen species (ROS). When malaria parasite (*Plasmodia*) consumes iron-rich haemoglobin w... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Nowadays cardiovascular diseases (CVDs) such as heart failure (HF) and myocardial infarction (MI), are considered the leading causes of death worldwide \[[@bib1],[@bib2]\]. As a matter of fact, pathological changes that occur in cardiac muscle, such as loss of cardiomyocytes, fo... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Diabetes mellitus is a risk factor for development of cataract.[@CIT1] Development of cataract is the second most ocular common complication of diabetic mellitus.[@CIT2] Up to 20% of all cataract surgery in the United Kingdom is performed in diabetics.[@CIT3] Furthermore epidemiolog... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-21-03421}
===============
Since the Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel was cloned in the last years of the 20th century \[[@B1-ijms-21-03421]\], there have been extensive efforts to reveal the structural and functional details of this protein. Thus, nowadays it is ... | {
"pile_set_name": "PubMed Central"
} |
{#Sec1}
The paper presents the first systematic review of the effectiveness of continuous quality improvement (CQI) compared to non-CQI approaches on improving the quality, safety and efficiency in any health care sector;It assesses the importance of the health care setting, the CQI model used and key components of t... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Aligning individual anatomy across brains is a key step in the processing of structural magnetic resonance imaging (MRI) for functional MRI (fMRI) studies. This brain registration process allows for comparison of local brain measures and statistics across subjects. A visual quality cont... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
The perception of mechanical cues is an integral part of cells that influences their performance and adaptation to the surrounding environment ([@R1], [@R2]). Cells are able to perceive forces exerted by substrates or adjacent cells to trigger specific signaling pathways, which, in turn, regu... | {
"pile_set_name": "PubMed Central"
} |
"Creativity that leaves a trace," is a quote cited by the renowned cardiac surgeon Dr. Tirone David at the 2019 Annual American Association for Thoracic Surgery (AATS) Inaugural Sugarbaker Memorial Lecture. This was a truly exceptional talk and will soon be published. AATS president and globally recognized mitral surge... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Novel gene expression technologies (e.g., microarrays, next-generation sequencing, etc.) make it possible to study the simultaneous expression of an ever increasing number of genes \[[@B1], [@B2]\]. As these technologies become more available and affordable, the size and complex... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s1}
===============
During ventricular diastole, the pressure falls below atrial pressure to allow the opening of atrioventricular valves. Blood then begins to flow passively from the atria into the ventricles to about 80% of their final volume. The atria then contract to propel the remaining 20% blo... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-23-01825}
===============
MicroRNAs (miRNAs) are endogenous short noncoding RNAs that cause post-transcriptional gene silencing in healthy cells. Knocking down first requires the binding of miRNA guide strands, complexed with silencing proteins, to complementary sequences in 3′-untrans... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction: {#sec1-jcm-08-01997}
================
Sickle cell disease (SCD) was first described by James Herrick, MD, in 1910 \[[@B1-jcm-08-01997]\]. He described the "peculiar elongated and sickle-shaped red blood corpuscles" that characterize this disorder. The missense mutation results from a single nucleotide... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-pharmaceuticals-09-00009}
===============
Cognitive dysfunction is a common feature of major depressive disorder (MDD), contributing to the serious decline in patients' quality of life. Described in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V, \[[@B1-pharm... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Although cancer begins as a single cell and initially develops as a clone, by the time a tumour is clinically detectable, it is no longer a mass of isolated, identical, neoplastic cells \[[@B1]\]. It has been realized that tumours are composed of an assemblage of cell types that communicate and c... | {
"pile_set_name": "PubMed Central"
} |
Most of the Earth's biosphere is cold (85% is permanently exposed to temperatures below 5 °C), with 14% being polar. Polar regions are areas of the globe surrounding the poles. They are different in that the Arctic is a frozen ocean surrounded by continental landmasses and open oceans, whereas Antarctica is a frozen co... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-jfb-10-00018}
===============
Calcium orthophosphates such as carbonated-apatites, calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU) are three main types of crystals associated with rheumatic diseases, responsible for hydroxyapatite rheumatism, CPP deposition disease and gout, re... | {
"pile_set_name": "PubMed Central"
} |
B. C. Baker, F. L. Mackie, S. C. Lean, S. L. Greenwood, A. E. P. Heazell, K. Forbes, R. L. Jones, Mol. Nutr. Food Res. 2017, 61, 1600646 <https://doi.org/10.1002/mnfr.201600646>
CDK6
: cyclin‐dependent kinase 6
FGR
: fetal growth restriction
hCG
: human chorionic gonadotropin
hPL
: human placental lacto... | {
"pile_set_name": "PubMed Central"
} |
Background {#s1}
==========
Extracellular vesicles (EVs) are double-layered membrane vesicles that may be released by cells in response to activation or during apoptosis ([@B1], [@B2]). Accumulating evidence shows that EVs are not inert, but usually carry an orchestrated cargo of proteins and nucleic acids with divers... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-17-01910}
===============
For more than a century, *Salmonella* has been recognized as the most frequently occurring pathogen in food affecting human's health. Salmonellosis has traditionally been linked to the consumption of food products of animal origin (e.g., meat, milk, and eggs) bu... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Although the cellular neuroanatomy of the SC is well established, we have little understanding of the distinct molecular expression patterns that underpin the functional heterogeneity of its constituent cells. This is particularly true for SC progenitors and neural stem cells (NSCs). Th... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
In 1936, mathematician Alan Turing put forward the first concept of a device for abstract computing, now called the Turing machine.[@cit1] Although a hypothetical device, it could manipulate sets of operations according to a table of prescribed rules to compute anything with a written a... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Health research studies aim to develop new treatments, improve the outcomes of treatment, allow public health and pharmaceutical surveillance, monitor health crises, increase the understanding of diseases and develop guidelines for best clinical practices \[[@CR1]\].
These studies can be... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Visceral leishmaniasis (VL) caused by protozoa of the genus *Leishmania* (Kinetoplastida: Trypanosomatidae) is a vector-borne neglected disease transmitted by phlebotomine sand flies (Diptera: Psychodidae) \[[@CR1]\]. *Leishmania infantum* (syn. *Leishmania chagasi*) is the most widesprea... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Maintenance of tissue barriers requires the ability to cope with diverse biomechanical strains. The vascular endothelium serves as the critical partition between the blood circulation and the interstitium, and failure of this barrier has devastating consequences ([@bib1]). Endothelia function... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Severe mental illnesses (SMI) or psychotic disorders, referring to bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia and schizoaffective disorder, cause long-duration and severe disability at different ages. Among them, schizophrenia and BD affect 2-4% of the wor... | {
"pile_set_name": "PubMed Central"
} |
The treatment of breast cancer is guided by risk factors. Approximately 70% of all node-negative breast cancer patients can be cured by locoregional therapy alone. This automatically implies that the remaining 30% of these patients will develop a recurrence despite adequate locoregional therapy. Currently, treatment st... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Cerebral microhemorrhages are tiny deposits of blood degradation products in the brain and are the pathological substrate of cerebral microbleeds (CMB). CMB are associated with increasing age, cerebrovascular diseases, hypertension, and chronic kidney disease (Lau et al., [@B19]). Mecha... | {
"pile_set_name": "PubMed Central"
} |
In the article titled "Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway" \[[@B1]\], the name of the first author was given incorrectly as Chu-Kung Chou. The author\'s name should have been written as Chu-Kuang Chou. The revised authors\' list is shown above.
Also, there was a... | {
"pile_set_name": "PubMed Central"
} |
J Diabetes Investig 2020; 11: 400--404
**Clinical Trial Registry**
*University Hospital Medical Information Network*
UMIN000018344
Introduction {#jdi13122-sec-0001}
============
Heart failure (HF) is a common and serious comorbidity in patients with type 2 diabetes, and its prevention is crucial[1](#jdi13122-bib-0... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Envenoming resulting from snake bites remains the most neglected public health issues in many countries, particularly in poor rural communities living in the tropics. *E. c. sochureki* causes numerous deadly bites especially in Asia \[[@B1], [@B2]\]. Generally envenoming by *Ech... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
==================
For the original monoclinic polymorph, see: Srivastava *et al.* (1967[@bb9]); Mereiter (2002[@bb4]). For background to direct synthesis, see: Nesterov *et al.* (2004[@bb6], 2006[@bb5]); Kovbasyuk *et al.* (1998[@bb3]); Vassilyeva *et al.* (1997[@bb10]). For bond-length dat... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Water column contains a mixture of microscopic particles of various sizes from colloidal non-living material to living microorganisms ranging from viruses, free-living and attached prokaryotes and unicellular eukaryotes ([@ref-11]). Mussels are efficient non-selective filter-feeders. They can... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Carbon nanoparticles suspension injection (CNSI) has been widely studied and applied in biomedical areas.[@b1-ijn-12-4891]--[@b3-ijn-12-4891] CNSI migrates fast in lymphatic vessel and accumulates in lymph nodes, thus shows high performance in tumor drainage lymph node (TDLN) imaging. Such at... | {
"pile_set_name": "PubMed Central"
} |
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{#sp9 .38... | {
"pile_set_name": "PubMed Central"
} |
I have always been curious about arthropods and the diseases they transmit to humans. Growing up in a malaria-endemic area (Benue, Nigeria) exposed my family members and me to the revulsions of malaria disease. Children were the worst hit. We had all sorts of symptoms (headaches, vomiting, joint pains, high fever, conv... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
The present case is compliant with the SCARE guidelines [@bib0005].
Post traumatic venous lesions are dominated by injuries and aneurysms. Another entity, not well described through the medical literature, is post traumatic venous thrombosis which can affect various location... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Linseed (*Linum usitatissimum* L.) is important for the oil and nutraceutical industries ([@b27]). Its oil, characterized by a high concentration of omega-3 alpha linolenic acid (∼55%), is widely recognized for its health benefits ([@b58]). A unique feature of linseed resides in the prospect ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Radical-based dynamic covalent chemistry (DCC) has continued to attract considerable attention in recent years due to its intriguing nature to form stable molecular self-assemblies *via* a clean radical--radical coupling process.[@cit1]--[@cit3] In particular, the stimuli-responsive nature of... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#j_hukin-2019-0047_s_001}
============
Biomechanics is the main field of objective research into the technical rules and methods of various kinetic skills. This is effected through precise measurements that are processed quantitatively by the laws of physics. There is no doubt that the objective study of... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
*Staphylococcus aureus* is a successful human pathogen, causing a large variety of diseases that range from minor skin infections to life-threatening bloodstream infections and endocarditis \[[@CR1]\]. Many of the virulence factors encoded by *S. aureus* are located within mobile genetic ... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
The APETALA2/Ethylene-Responsive Factor (AP2/ERF) gene family is one of largest gene families, encoding plant-specific transcription factors. The AP2/ERF superfamily is defined by the AP2/ERF domain, which... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Behavior is primarily an output of the nervous system in response to internal or external stimuli. It is hierarchical, dynamic, and high dimensional, and is generally simplified for analysis^[@CR1],[@CR2]^. For instance, the rich locomotor movement performed by a mouse that is capture... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Two-photon excitation is a phenomenon in which two photons are simultaneously absorbed by a molecule, causing excitation. Because visible fluorophores are used for bioimaging, near-infrared (NIR) laser light pulses are used to induce two-photon excitation processes. The excitation ind... | {
"pile_set_name": "PubMed Central"
} |
Lauren Abrey
Switzerland
Mario Airoldi
Italy
Ichiro Akagi
Japan
David Allan
Canada
Filippo Alongi
Italy
Michelle Alonso-Basanta
United States of America
Dante Amelio
Italy
Richard Amos
United States of America
Franc Anderluh
Slovenia
Fundagul Andic
Turkey
Nicolaus Andratschke
Germany
Carmen Ares
... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Large-conductance Ca^2+^- and voltage-dependent K^+^ (BK) channels display diverse biological functions in different cells and tissues. The functional diversity arises mainly from the channel pore-forming α subunits assembling with up to four tissue-enriched auxiliary β subunits (β1-β... | {
"pile_set_name": "PubMed Central"
} |
CD81 is a member of the tetraspanin family, which encompasses membrane proteins characterized by four transmembrane domains ([@bib2]). CD81 is expressed by many cells of the hematopoietic system, including B cells, T cells, monocytes, and dendritic cells. The functions of CD81 are multifaceted, including roles in immun... | {
"pile_set_name": "PubMed Central"
} |
Therapeutic hypothermia (TH) is one of the most robust neuroprotectants in ischemic stroke and has been proved to reduce infarct size, protect the blood brain barrier (BBB) from breakdown and alleviate edema formation in animal models \[[@b1-ad-9-4-685]\]. The potential mechanisms may include the inhibition of post-isc... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Left main coronary artery (LMCA) disease is largely dominated by atheromatous stenosis with variable scale of severity. The total occlusion of LMCA is still a surprising discovery in a cardiac catheterization laboratory with a very low incidence ranging from 0.04 to 0.43% in a reporte... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#section1-2192568219858302}
============
Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in patients older than 55 years.^[@bibr1-2192568219858302],[@bibr2-2192568219858302]^ Cervical laminectomy is a well-established surgical treatment option for multilevel CSM,... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
In early genome-wide association studies (GWAS), massive amounts of results have been reported on the associations between single-nucleotide polymorphisms (SNPs) and diseases. By now, 2,051 studies and 14, 836 causal variants (*p* value ≤5.0 × 10^−8^) have been added to catalogu... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Bacterial-incited plant diseases account for significant production losses to agricultural crops. Disease control is a major challenge as a result of various factors including pathogen variation, ability to overcome plant genetic resistance, lack of effective bactericides as a result of strai... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Thermostability is a basic biophysical property of a protein. It connects tightly to protein expression, folding, activities and functions. Therefore, thermostability is one of the most important criteria ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Four species of ragweed (from the genus *Ambrosia*) have been introduced to Europe from North America. The foremost of these is common ragweed (*Ambrosia artemisiifolia L.*), which is an important weed in agriculture and a source of highly allergenic pollen. It poses a threat to human... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#S1}
============
SARS-CoV-2, the etiologic agent of COVID-19, has spread globally reaching all continents^[@R1],[@R2]^. Ecuador was the second country in South America, after Brazil, to report its first case on 29 February 2020^[@R3]^. The number has grown since, reaching 39,098 laboratory-confirmed cas... | {
"pile_set_name": "PubMed Central"
} |
Cellulosic biofuel production in the United States has fallen behind federally mandated levels and, at the current trajectory, is not on track to meet the 16 billion gallons per year target by 2022 ([@r1]). This lag is due to several factors, including the recent global economic recession in the late 2000s and the dram... | {
"pile_set_name": "PubMed Central"
} |
PRESENTATION {#sec1-1}
============
A 23-year-old male presented with a history of sudden onset painless diminution of vision in the left eye (LE) following bouts of vomiting 4 months ago. His vision had gradually improved over the previous 2 months. There was no history of steroid use. Visual acuity was 20/20 in both... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .562}
| {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Being still lack of effective treatments for Alzheimer\'s disease (AD), current research efforts have focused on finding the relationships between amyloid-β peptide (Aβ) functions and toxic mechanisms to understand the development of AD (Huang and Mucke, [@B27]). Memory deficits and dis... | {
"pile_set_name": "PubMed Central"
} |
Bridgman discovered van der Waals bonded black phosphorus crystals in 1914 during high-pressure experiments[@b1]. While much of its bulk semiconducting properties have been investigated for one hundred years[@b2], it is only recently that few-layer black phosphorus or phosphorene, an elemental two-dimensional (2D) laye... | {
"pile_set_name": "PubMed Central"
} |
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