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Under natural fluctuations in light environments, green plants and algae fine-tune the light-harvesting system in chloroplast thylakoid membranes to maintain the optimal conditions of photosystems[@b1]. When light absorption in photosystem II (PSII) exceeds that in photosystem I (PSI), the intersystem electron carrier ...
{ "pile_set_name": "PubMed Central" }
![](edinbmedsurgj73248-0238){#sp1 .494} ![](edinbmedsurgj73248-0239){#sp2 .495} ![](edinbmedsurgj73248-0240){#sp3 .496} ![](edinbmedsurgj73248-0241){#sp4 .497} ![](edinbmedsurgj73248-0242){#sp5 .498} ![](edinbmedsurgj73248-0243){#sp6 .499} ![](edinbmedsurgj73248-0244){#sp7 .500} ![](edinbmedsurgj73248-0245){#sp8...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The incidence of post-operative nausea and vomiting (PONV) in patients who undergo operations in which general anesthesia is administered has been reported to range 20-30% \[[@B1]\]. PONV results in some of the most severe discomfort amongst patients, along with post-operative pain. The cause...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files, except for: gene expression data have been deposited in the NCBI's Gene Expression Omnibus (GEO, <http://www.ncbi.nlm.nih.gov/geo>, GEO Series accession number GSE60971), according to the Minimum Information About a Microarray Experiment (MIAM...
{ "pile_set_name": "PubMed Central" }
1. Introduction of Optogenetics {#sec1-mps-02-00034} =============================== If you were seeking information on "optogenetics" in a biology, physiology, or even neuroscience textbook published roughly ten years ago, you would be left wanting. Yet, a *pubmed* search using the same keyword in early 2019 returns ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Alcohol use is the behaviour that has the most significant impact on the mortality and morbidity of young people \[[@CR1]\], and binge drinking is becoming the norm among this population \[[@CR2]\]. Excessive cannabis and/or alcohol use in adolescence has many negative short- and long-ter...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ The vertebrate retina is an excellent model to study the development of the nervous system including the cell differentiation process. Although more than 50 subtypes of retinal neurons have been identified ([@b42]), the vertebrate retina is mainly composed of six major types of neurons ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Primary and secondary focal segmental glomerulosclerosis (FSGS) are a major cause of nephrotic syndrome in the United States and often lead to end-stage renal disease (ESRD) \[[@B1]\]. FSGS is diagnosed and classified from renal biopsies \[[@B2], [@B3]\]. Injury of podocytes ini...
{ "pile_set_name": "PubMed Central" }
Published: February 26, 2019 Introduction {#sec1} ============ The intestinal epithelium is the barrier that mediates interactions between the intestinal lumen and the rest of the body. Proper intestinal function depends on the development and maintenance of organization of epithelial cells into two distinct compartm...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Vulva cancers are very rare and serious tumors \[[@B1]\]. Infection with human papillomavirus (HPV) is the main risk factor in the occurrence of vulva cancers, especially in young women \[[@B2]\]. We report a case of poorly differentiated squamous cell carcinoma of the vulva in ...
{ "pile_set_name": "PubMed Central" }
1. Introduction =============== An appropriate education from an early stage in their life is critical to ensuring the integration of anyone into society. Literacy development is a key factor in this. Literacy starts at home and continues both in school and throughout life. In the case of children with Down syndrome, ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-cells-09-01894} =============== After myocardial infarction (MI), cardiomyocyte death activates cellular and structural remodeling of the heart: Remaining cardiomyocytes take on an additional contractile load, leading to cardiomyocyte hypertrophy, while fibroblasts proliferate, produce extracell...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
Introduction ============ The important role of non-coding elements of the genome, specifically microRNAs (miRNAs), in mediating cellular transformation was first demonstrated in chronic lymphocytic leukemia.^[@b1-1032049]^ Since then, numerous miRNAs have been shown to function as tumor suppressors or oncogenes in bo...
{ "pile_set_name": "PubMed Central" }
Pneumonia has been referred to as captain of men of death in the past. Although the situation is not so grim today, the pneumonia has potential to cause significant problems in terms of morbidity and mortality. The misery has been reduced over the years perhaps because of the nature of disease allowing focused research...
{ "pile_set_name": "PubMed Central" }
Citation ======== Yang Y, Su J, Yang X (2014) Description of six new species of *Lycocerus* Gorham (Coleoptera, Cantharidae), with taxonomic note and new distribution data of some other species. ZooKeys 456: 85--107. doi: [10.3897/zookeys.456.8465](10.3897/zookeys.456.8465) Introduction ============ *Lycocerus* Gorh...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== One primary pathology of Alzheimer's disease (AD) is the accumulation of insoluble amyloid-β (Aβ) plaques in the brain. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases \[[@CR1], [@CR2]\]. Alternatively, activity of another type of enzyme...
{ "pile_set_name": "PubMed Central" }
Introduction ============ In recent years several articles have been published on the intestinal microbiota composition of chickens and its associations with production and health ([@B76]; [@B9]; [@B51]; [@B119]; [@B146]). For instance, some studies have described differences in bacterial species abundance for broiler...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Epigenetic regulation, including histone modification, is an important mechanism that mediates gene expression by modifying the chromatin structure without changing the DNA sequences and is also essential for cell differentiation and tissue development. Aberrations of this regulation ca...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Antibody--drug conjugates (ADCs) provide an effective treatment strategy for both hematological malignancies and, increasingly, solid tumors. An ideal ADC combines the unique ability of an antibody to specifically bind a tumor-associated antigen that is minimally or in best case not expressed...
{ "pile_set_name": "PubMed Central" }
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is infecting people throughout the world. It is probable that coronavirus disease (COVID-19) will be transmitted to people experiencing homelessness, which will become a major problem in particular in North America where there are sizable populations of peopl...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The neurotrophin receptor p75 (p75^NTR^)[\*](#fn1){ref-type="fn"} is a membrane glycoprotein that binds to all neurotrophins identified so far. Motor neurons in the spinal cord, most sympathetic and sensory neurons in the peripheral nervous system, and cerebellar Purkinje cells and retinal ga...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Although evolution mostly proceeds by accumulation of differences between groups, numerous examples of convergent evolution exist, where similar solutions are found to similar evolutionary problems. Well-known morphological examples include eyes and wings, but an increasing number of examples...
{ "pile_set_name": "PubMed Central" }
Genetic factors shared among diverse autoimmune disorders ========================================================= Autoimmune disorders (AIDs), which as a group affect approximately 8.5% of individuals worldwide \[[@B1]\], are responsible for a substantial amount of disability and morbidity. Some AIDs are organ speci...
{ "pile_set_name": "PubMed Central" }
**What was known?** Local reactions to BCG vaccine include lymphadenitis (mostly involving ipsilateral axillary nodes, rarely supraclavicular, nuchal, or cervical), abscesses, ulceration, and persistent injection-site reactions. There is no Tunisian series exclusively reporting BCG vaccine adverse reactions. Introduc...
{ "pile_set_name": "PubMed Central" }
COMMON SPECIES KEPT IN CAPTIVITY {#cesec1} ================================ Modern-day crocodilians date back to the Mesozoic era over 65 million years ago, surviving to the present with relatively few evolutionary changes. Their biology, physiology, and anatomy are unlike those of any other reptiles. However, some sp...
{ "pile_set_name": "PubMed Central" }
Cancer Medicine 2016, 5(12):3394--3402 27781400 Introduction {#cam4927-sec-0001} ============ As the third leading cause of cancer death among both men and women and the third most common cancer in the United States, colorectal cancer is associated with substantial morbidity and mortality in the nation\'s population....
{ "pile_set_name": "PubMed Central" }
T. Amano, N. Fujii, G. P. Kenny, Y. Inoue, N. Kondo. Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance‐trained athletes?. Physiol Rep, 5 (17), 2017, e13403, <https://doi.org/10.14814/phy2.13403> 28899912 **Funding Information** This study was supported by ...
{ "pile_set_name": "PubMed Central" }
Introduction {#section5-2382120520947062} ============ The Coronavirus Disease 2019 (COVID-19) pandemic has presented academic medical institutions with a unique set of challenges with respect to ensuring the safety and well-being of resident physicians. The Accreditation Council for Graduate Medical Education (ACGME)...
{ "pile_set_name": "PubMed Central" }
Millions of people worldwide have survived an admission to the intensive care unit (ICU), and the number of survivors is growing \[[@C1]\]. While these patients have survived a life-threatening illness, most survivors suffer important long-term complications \[[@C2]\]. Post-intensive care syndrome (PICS) is a term that...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the manuscript and its Supporting Information files. Introduction {#sec001} ============ Emerging viral infections pose a constant threat to humans and animals. Viral emergence causing an epidemic of disease in a new host is a rare event, despite the wide diversity of viruses that are kno...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== MicroRNAs (miRNAs) are short (typically 20--26 nucleotides), non-coding RNAs generated from genomic DNA, and they generally exert negative post-transcriptional regulation (including translational repression, mRNA destabilization, and/or mRNA cleavage) by binding to target mRNAs via the RN...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ The branching patterns of reconstructed molecular phylogenies contain information about the tempo and mode of evolution [@pone.0043348-Raup1], [@pone.0043348-Nee1]. This insight has been invaluable to our understanding of many evolutionary processes and patterns. Recent studies have ide...
{ "pile_set_name": "PubMed Central" }
Central glucose level can modify neural activity through sodium‐glucose co‐transporter 1 (SGLT1) as well as glucose transporters. A recent publication from Fan *et al*.[1](#jdi12527-bib-0001){ref-type="ref"} revealed a new glucose‐sensing mechanism in the central nervous system (CNS). Many previous studies have pointe...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Sport-related concussion or mild traumatic brain injury (TBI) is a perilous trauma that could impair the brain function of an injured athlete both acutely and in a long-term perspective. Up to 3.8 million sport-related concussions occur in the United States annually ^[@ref-1]^, with contact s...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Acquired Immune Deficiency Syndrome (AIDS) has been an epidemic worldwide since the 1980s. The Joint United Nations Programme on HIV and AIDS (UNAIDS) proposed a global goal: end the AIDS epidemic as a public health threat by 2030. However, 37.9 million people were living with h...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Despite the global prevalence of obesity a high proportion of parents continue to misclassify their child's weight status \[[@CR35], [@CR40]\]. The majority of studies demonstrate parental underestimation of child weight status \[[@CR12], [@CR16], [@CR32]\]. Considerable research has been...
{ "pile_set_name": "PubMed Central" }
Background {#S1} ========== Major depressive disorder (MDD) is a leading cause of disability and disease affecting millions of individuals worldwide ([@B1], [@B2]). MDD includes alterations in mood, neurovegetative functions, cognition, and psychomotor activity, and it represents a major public health concern because ...
{ "pile_set_name": "PubMed Central" }
Introduction {#section1-1536012117723256} ============ Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third most common cause of cancer-related deaths.^[@bibr1-1536012117723256]^ Asymptomatic progression and thus difficult early detection, as well as underdeveloped therapeutic strategie...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Recurrent miscarriage (RM) has been defined as two or more consecutive pregnancy losses prior to the 20th week of gestation in human, and occurs in 1--2 % of pregnant women at reproductive age \[[@CR1], [@CR2]\], and the etiology of 68 % RM cases are unexplained \[[@CR3]\]. Although the f...
{ "pile_set_name": "PubMed Central" }
Antibiotic resistance has become one of the forefront issues in global health because of the emergence of multidrug-resistant (MDR) bacteria. According to the Centers for Disease Control and Prevention (CDC), an estimated two million people each year acquire MDR bacterial infections, of which 23,000 are fatal.^[@ref1]^...
{ "pile_set_name": "PubMed Central" }
Stones/Endourology Introduction {#s0005} ============ The introduction of shockwave lithotripsy (SWL) treatment for renal and ureteric calculi in 1983 changed the treatment of smaller stones. Over time the indications and techniques have been constantly redefined in the pursuit of better outcomes. With the advent of ...
{ "pile_set_name": "PubMed Central" }
When bacteria invade, the immune system reacts violently to bacterial endotoxin (or lipopolysaccharide \[LPS\])--a component of gram-negative bacterial cell walls. Why then does the immune system slowly stop reacting to LPS after repeated exposure? Perhaps this process allows the body to prevent excessive inflammation;...
{ "pile_set_name": "PubMed Central" }
Introduction ============ The International Council for Control of Iodine Deficiency Disorders (ICCIDD) estimated recently that 28.5% of the world's population have insufficient dietary iodine intake as indicated by a urinary iodine concentration less than 100 µg/L.[@R1] Proportions of the population with iodine defic...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Type 2 diabetic osteoporosis (T2DOP) is a severe chronic complication that affects the skeletal system and is caused by diabetes ([@b1-etm-0-0-8943]). T2DOP has become a common secondary cause of osteoporosis that accelerates bone loss and leads to bone fractures ([@b1-etm-0-0-8943]). The inc...
{ "pile_set_name": "PubMed Central" }
T.P. Salazar-Mather and L. Malmgaard contributed equally to this work. Introduction ============ Type I IFN-α/β and IL-12 are innate cytokines which can be induced early during certain viral infections. They play critical roles in defense against viruses through antimicrobial as well as immunoregulatory effects ([@bi...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ It is commonly assumed that tactile sensory processing is transmitted from the periphery to the cortex through parallel feedforward pathways, which ran through well-defined neuronal aggregates, grouped into rows and arcs, in the brainstem (barrelets), thalamus (barreloids), and somato...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Access to healthcare in prison is an increasing public health concern that should be included in the public health agenda. All over the world, the prevalence of sexually transmitted infections (STIs) and blood-borne infections is higher among the imprisoned population than in the general popu...
{ "pile_set_name": "PubMed Central" }
Corrigendum {#sec1} =========== Le Dr Farih Moulay Hassan n'avait pas été ajouté dans la première liste d'auteur de l'article original \[[@cit0001]\]. Pourtant, il devait y figurer en tant que dernier auteur de la liste, son affiliation étant "Service d\'Urologie, CHU Hassan II, Fèz, Maroc". Il a contribué au même tit...
{ "pile_set_name": "PubMed Central" }
ANNOUNCEMENT {#s1} ============ Many species of phytophagous stink bugs belonging to the superfamilies Coreoidea and Lygaeoidea, and members of the family Largidae in the superfamily Pyrrhocoroidea, develop specialized crypts at the posterior region of the midgut, the lumen of which is densely colonized by beneficial ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Several chemotherapeutic drugs are known to be neurotoxic and can lead to chemotherapy-induced peripheral neuropathy (CIPN). It is one of the main dose-limiting toxicities in oncologic treatments and a potential reason to terminate or suspend chemotherapy, in some cases leading ...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Pre-eclampsia (PE) is a malignant syndrome of pregnancy mediated by abnormal placentation and subsequent dysfunction. It affects 2--8% of all pregnancies ([@B1]) and occurs most commonly in the third trimester but may also develop intrapartum or early postpartum ([@B2]). Pre-eclampsia i...
{ "pile_set_name": "PubMed Central" }
Data are available within the manuscript and its Supporting Information files. The raw data of the RNA-seq study are deposited at the NCBI sequence read archive (SRA) with the accession number PRJNA638422. Introduction {#sec001} ============ *Drosophila* blood cells, also called hemocytes, contribute to the cellular ...
{ "pile_set_name": "PubMed Central" }
###### Strengths and limitations of this study - This study adds to a limited body of literature evaluating implementation, effects and costs of multicomponent, community-based campaigns to prevent HIV in men who have sex with men (MSM). - The study is interdisciplinary and uses data on campaign implementation an...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ Despite commendable advancements in the prevention, detection and treatment of cancer, oral squamous cell carcinoma (OSCC) still remains a significant global health burden, accounting for over 260,000 diag...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ The roots of most plants form intimate mutualistic associations with soil fungi known as "mycorrhizae." The mycorrhizal symbiosis is both ancient (among early land plants 410 ma) and pervasive (\>80% of plants participate; [@B67]), and thus underpins most terrestrial ecosystems, the soil port...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Influenza A virus is an orthomyxovirus with eight negative sense RNA segments. Emergence of influenza pandemics in the human population occurs when gene segments of at least two viruses reassort, creating a novel virus that expresses a hemagglutinin (HA) and or neuraminidase (NA) gene t...
{ "pile_set_name": "PubMed Central" }
The challenges and responses {#s1} ============================ The COVID-19 pandemic is placing extraordinary and sustained demands on health systems and providers of essential community services (Emanuel *et al.* [@r10]). The media focus on the number of cases, intensive care unit capacity and ventilator numbers ref...
{ "pile_set_name": "PubMed Central" }
Related literature {#sec1} ================== For other 3,5-substituted-1*H*-pyrazolate complexes, see: Driessen *et al.* (2003[@bb2]); Eisenwiener *et al.* (2007[@bb3]); King *et al.* (2004[@bb5]); Li (2005[@bb6]); Penkova *et al.* (2008[@bb9]); Tretyakov *et al.* (2008[@bb12]). Experimental {#sec2} ============ {...
{ "pile_set_name": "PubMed Central" }
Despite extensive evidence that environmental tobacco smoke (ETS) is associated with an increased risk of detrimental health effects, \> 40% of U.S. children are exposed to ETS in their homes ([@b41-ehp0113-000098]). Exposure to ETS has consistently been linked with adverse health effects in children, including middle ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Renal cell carcinoma (RCC) is the most common primary renal tumor, and originates from the renal cortex \[[@CR1]\]. Worldwide, the incidence of RCC has increased over the last thirty years \[[@CR2]\]. After the surgical treatment of RCC, the possibility of recurrent tumors is 10-20% \[[@C...
{ "pile_set_name": "PubMed Central" }
![](glasgowmedj75531-0064){#sp1 .320}
{ "pile_set_name": "PubMed Central" }
What Do We Already Know about This Topic? {#section1000-2325958220919231} ========================================= TDF and TAF are both recommended treatment options for HIV and hepatitis B. How Does Your Research Contribute to the Field? {#section2001-2325958220919231} ==============================================...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ The estimated overall prevalence of type 2 diabetes in China was 10.9% in 2013 according to a national survey ([@B1]). This may result in a proportional increase of chronic kidney disease (CKD) related to diabetes mellitus ([@B2]). Indeed, both reduced kidney function and albuminuria ar...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Protein phosphorylation and dephosphorylation is known to play a critical role in many aspects of neuronal function, including in key steps that are involved in both strengthening and weakening of synaptic communication ([@bib11]; [@bib29]; [@bib49]; [@bib33]). For example, the serine/threoni...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Amino acids play exclusive roles in the synthesis of a large number of biologically important compounds, such as proteins, peptides, lipids, and vitamins. In addition, free amino acids and their metabolites are involved in many physiological functions, especially synaptic transmission...
{ "pile_set_name": "PubMed Central" }
![](menthealthlond70366-0031){#sp1 .28} ![](menthealthlond70366-0032){#sp2 .29}
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ During cell division, chromosomes often form syntelic attachments, wherein both sister kinetochores establish end-on attachments with microtubules from the same spindle pole ([Fig. 1 A](#fig1){ref-type="fig"}). For accurate chromosome segregation, these erroneous attachments must be cor...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Nonhomologous end joining (NHEJ) is a key pathway for repair of chromosome breaks in mammals. A number of factors are required for efficient rejoining of broken chromosome ends regardless of the structure of the broken end (core factors). These include a ligase complex of XRCC4 and DNA ligase...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Ovarian cancer is the leading cause of death from gynaecologic cancer, and it is estimated that 22,280 new diagnoses and 14,240 deaths from this neoplasm will occur in United States in 2016 \[[@R1]\]. Standard treatment is platinum (Pt)-based chemotherapy and surgical debulking of the t...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ Benign turnours of lung comprise fewer than 1 % of all resected lung tumours.[@CIT1] Except hamartomas and carcinoid turnours, all of the benign turnours of lung are rare.[@CIT2] Endobronchial benign tumours often present with features of partial or complete bronchial obstruction, h...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Infections of the upper respiratory tract (URTI) are among the most frequent infections worldwide. These are mainly caused by RNA viruses. Among them, influenza viruses (IV), pneumoviruses (respiratory syncytial virus, RSV; human metapneumovirus, HMPV), but also parainfluenza viruses ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ In aging research, we tend to think of variables changing in one direction with increasing age, from better to worse. But between birth and old age the picture is more complex; a wide range of variables first improve, then deteriorate. This is true of cellular ([@B52]), psychological ([@B62])...
{ "pile_set_name": "PubMed Central" }
1.. Introduction   {#sec1} ================== The automation of data collection at macromolecular crystallography (MX) beamlines is important for the efficient use of the limited beamtime. One key apparatus for automation is a sample-changer robot; this enables samples to be exchanged without entering the experimental...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Background {#s1a} ---------- Health care delivery must continuously evolve and adapt to the changing context in coordination with the social and economic development, which constantly result in the demographic/epidemiology transition and disease burden shifting. One of the major change...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ Posterior urethral valve (PUV) is a common cause of bladder outlet obstruction in male children. Vesical calculi are commonly seen in developing countries in pediatric age group patients belonging to poor economic status. There are various congenital and acquired causes for bladder ...
{ "pile_set_name": "PubMed Central" }
![](edinbmedj73976-0058){#sp1 .632} ![](edinbmedj73976-0059){#sp2 .633}
{ "pile_set_name": "PubMed Central" }
DESCRIPTION of CASE {#s1} =================== A 63-year-old man presented to our accident and emergency department with a 2-hour history of crushing central chest pain, excessive sweating, and difficulty in breathing. Past history included non-insulin-dependent diabetes mellitus controlled by oral hypoglycaemic agents...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Improving the charge performance of Li-ion batteries for a wide spectrum of applications from mobile devices to electric vehicles is a major goal of contemporary materials research. Charge performance is typically limited by the rate of charge/discharge that can be sustained by the po...
{ "pile_set_name": "PubMed Central" }
The seventh author\'s name is spelled incorrectly. The correct name is: Christian Milani.
{ "pile_set_name": "PubMed Central" }
1. Introduction {#s1} =============== Current biological research, including pathogen related research projects, are increasingly dependent on public genome databases. Genome databases provide information about genomic sequences (Benson et al., [@B8]), gene annotations (Aken et al., [@B1]), protein sequences (Punta et...
{ "pile_set_name": "PubMed Central" }
Sir, Priapism after neuraxial or general anaesthesia is rare and may delay or even cancel the planned urological procedure. Our patient was a 66-year-old gentleman with hypertension, diabetes, coronary artery disease (double vessel disease, anterolateral wall myocardial infarction 2 years back), and chronic obstructiv...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ DNA vaccines have great potential for treating infectious and non-infectious diseases throughout the world ([@B1]). They are inexpensive to produce and can be easily modified to accommodate a variety of targets. In addition, DNA vaccines offer the greatest likelihood of protecting again...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#s0005} =============== Livestock diseases can impact animal production and adversely affect the security of the human food supply chain. Added to that, many livestock diseases are zoonotic in nature and can infect humans via several routes. Parasitic zoonoses continue to pose serious concerns at the ...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ One of the outstanding problems in interdisciplinary science is nonlinear and complex systems identification, prediction and control. Given a complex dynamical system, the various types of dynamical processes are of great interest. The ultimate goal in the study of complex systems is ...
{ "pile_set_name": "PubMed Central" }
![](brjcancer00418-0144.tif "scanned-page"){.149} ![](brjcancer00418-0145.tif "scanned-page"){.150}
{ "pile_set_name": "PubMed Central" }
Related literature   {#sec1} ==================== For methods of preparation of 3-alkyl- or 3-aryl-3-hy­droxy­quinoline-2,4-diones by oxidation of the corresponding 3-alkyl- or 3-aryl­quinolin-2-ones, see: Stadlbauer & Kappe (1982[@bb11]); Stadlbauer *et al.* (1992[@bb12]). For naturally occurring 3-hy­droxy­quinoline...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Tissue perfusion after cardiac surgery may become impaired due to multiple factors and in turn induce organ dysfunction, organ failure, prolonged stay in intensive care unit (ICU) and in hospital and increased mortality \[[@CR1]\]. Unfortunately, the adequacy of tissue perfusion remai...
{ "pile_set_name": "PubMed Central" }
Prostate cancer affects a large number of men worldwide: over a million new cases were diagnosed in 2012 (\>320,000 in Europe) \[[@bb0005]\]. The recognised changes in demography (aging) and lifestyle (obesity) of the male population are predicted to give rise to an increase in the incidence of prostate cancer \[[@bb00...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ The novel coronavirus disease 2019 (COVID-19), an outbreak caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), continues to spread, and as per the World Health Organization (WHO) data on April 21, 2020, it has reached 213 countries, with 23,56,414 confirmed cases and 1...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ At present barley (*Hordeum vulgare* L.) is the fourth most important cereal crop, after maize, wheat and rice. Barley is a diploid (2*n* = 14) self-pollinating species which can be used as a model plant for other *Triticeae* species providing an excellent system for genome mapping an...
{ "pile_set_name": "PubMed Central" }
To the editors of the Pan African Medical Journal {#sec1} ================================================= There is an abundance of literature addressing the everlasting legal/ethical/moral controversies about the off-label use/prescribing of medicines and the need to streamline the practice \[[@cit0001],[@cit0002]\]...
{ "pile_set_name": "PubMed Central" }
Global approaches to health such as One Health or EcoHealth paradigms posit that the epidemiological dynamics and stakeholders' actions that determine the health of animal and human populations need to be studied in their interconnected ecological, socioeconomic, and political contexts. So far they have received scant ...
{ "pile_set_name": "PubMed Central" }
The electronic version of this article is the complete one and can be found at: <http://f1000.com/reports/b/2/86> Introduction and context {#s01} ======================== In normal cells, a tight coordination between cell adhesion and signaling exists, manifested by a dependence on anchorage for growth. As cancer cel...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Barania Góra (1,220 m above sea level) is the second highest mountain in the Silesian Beskids range, part of the Western Carpathians. It stretches mainly south and northward and is a watershed between the Vistula valley from the west and the Soła valley from the east. The rock body of...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Herbal medicines are becoming an increasing component of Western pharmacotherapy mostly due to the perception that "natural" means "safe" (Brantley et al., [@B5]). As a result, a large number of patients with diabetes use them alongside their prescription drugs in disease management (Ar...
{ "pile_set_name": "PubMed Central" }
Introduction {#S1} ============ Multiple sclerosis (MS) is a devastating autoimmune disease, often afflicting those in the prime of their lives. In the US alone, 200 new cases are diagnosed each week; however, current MS treatments are non-curative, side-effect prone, and expensive, highlighting the need for expanded ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-molecules-24-03543} =============== Protein kinases serve as therapeutic targets for a range of clinical indications and represent the largest category of drug targets in current clinical trials \[[@B1-molecules-24-03543]\]. The first-generation Bcr-Abl inhibitor imatinib achieved great clinical...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ The pathogenesis of gastrointestinal problems caused by different etiologies was observed to be associated with the alterations of various physiologic parameters such as reactive oxygen species (ROS), nitric oxide synthase (NOS), lipid peroxidation, and secretion of excessive gastri...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Thrombosis associated with thrombocytopenia has been emphasized in several studies as a potentially fatal complication of heparin. After searching PubMed, Sid and Elsevier, we found 7 case reports that described several types of heparin-induced thrombocytopenia (HIT) treatment. The use of lep...
{ "pile_set_name": "PubMed Central" }