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Improvement of the low knowledge, attitude and practice of hepatitis B virus infection among Saudi national guard personnel after educational intervention. | BACKGROUND: Although the risk of hepatitis B virus (HBV) was reported to be higher in military personnel than the general population in Saudi Arabia (SA), there is lack of studies assessing HBV awareness among them. The objective was to evaluate the knowledge, attitude and practice (KAP) of HBV infection among military... | ['Adult', 'Health Education', 'Health Knowledge, Attitudes, Practice', 'Hepatitis B', 'Humans', 'Male', 'Military Personnel', 'Saudi Arabia', 'Surveys and Questionnaires'] | 23,111,118 | [['M01.060.116'], ['I02.233.332', 'N02.421.726.407'], ['F01.100.150.500', 'N05.300.150.410'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.625'], ['Z01.252.245.500.750'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.8... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A comparison of antidepressant response in younger and older women. | The objective of this report is to compare antidepressant response rates and tolerability in younger and older women. One hundred fifteen female outpatients who met DSM-IV criteria for major depressive disorder were evaluated before and after 8 weeks of treatment with a selective serotonin reuptake inhibitor, nefazodon... | ['Adult', 'Aged', 'Aging', 'Antidepressive Agents', 'Antidepressive Agents, Second-Generation', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Middle Aged', 'Piperazines', 'Psychiatric Status Rating Scales', 'Sertraline', 'Sex Characteristics', 'Triazoles'] | 12,920,418 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['D27.505.954.427.700.122'], ['D27.505.954.427.700.122.050'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.383.606'], ['F04.711.513.653'], ['D02.092.705.800', 'D02.455.426.559.847.638.845.800', 'D04.615.638.845.800']... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacokinetics and pharmacodynamics of rocuronium at the vocal cords and the adductor pollicis in humans. | The pharmacokinetic-pharmacodynamic relationship of rocuronium at the laryngeal adductor muscles and the adductor pollicis was determined in eight patients during general anesthesia. Rocuronium was administered as an infusion at a rate of 100 micrograms.kg-1.min-1 over 5 minutes. The half-life of transport between plas... | ['Adult', 'Androstanols', 'Half-Life', 'Humans', 'Middle Aged', 'Muscles', 'Neuromuscular Nondepolarizing Agents', 'Rocuronium', 'Thumb', 'Vocal Cords'] | 7,648,768 | [['M01.060.116'], ['D04.210.500.054.040'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633', 'A10.690'], ['D27.505.696.663.700.710.575'], ['D04.210.500.054.040.783'], ['A01.378.800.667.430.705'], ['A04.329.364.737']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins. | Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advan... | ['Animals', 'Drug Interactions', 'Fluorobenzenes', 'Hepatocytes', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Liver', 'Liver-Specific Organic Anion Transporter 1', 'Male', 'Mice', 'Organic Anion Transporters', 'Organic Anion Transporters, Sodium-Independent', 'Pravastatin', 'Pyrimidines', 'RNA, Messeng... | 24,855,184 | [['B01.050'], ['G07.690.773.968'], ['D02.455.426.559.389.358', 'D02.455.526.510.432'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954.557.500.202.370'], ['A03.620'], ['D12.776.157.530.450.074.500.781.500', 'D12.776.157.530.937.580', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo and in vitro bisphenol A exposure effects on adiposity. | In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As adipogenesis is a critical factor contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn adipose tissue at the stem-cell level. For in vivo studies, female... | ['Adipocytes', 'Adipogenesis', 'Adipose Tissue', 'Adiposity', 'Animals', 'Animals, Newborn', 'Benzhydryl Compounds', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Disease Models, Animal', 'Endocrine Disruptors', 'Estrogens, Non-Steroidal', 'Female', 'Humans', 'Male', 'Maternal Exposure', 'Mesenchyma... | 30,156,179 | [['A11.329.114'], ['G04.152.149'], ['A10.165.114'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['B01.050'], ['B01.050.050.282'], ['D02.455.426.559.389.115'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.0... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical usefulness of the serum carboxypeptidase B activation peptide in acute pancreatitis. | OBJECTIVE: To assess the sensitivity and specificity of the serum carboxypeptidase B activation peptide in diagnosing and determining the severity of acute pancreatitis.PATIENTS: Twenty consecutive patients with acute pancreatitis were studied on admission to the Emergency Room: 11 patients had mild pancreatitis, and 9... | ['Acute Disease', 'Adult', 'Aged', 'Aged, 80 and over', 'Amylases', 'Female', 'Humans', 'Lipase', 'Male', 'Middle Aged', 'Pancreatitis', 'Peptides', 'Sensitivity and Specificity', 'Severity of Illness Index'] | 11,854,559 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.811.277.450.066'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.352.100.400'], ['M01.060.116.630'], ['C06.689.750'], ['D12.644'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanics of self-stimulation and dopamine release in the nucleus accumbens. | Robust self-stimulation can be obtained from electrodes implanted in the medial forebrain bundle. We used in-vivo voltammetry to monitor stimulated dopamine release in the mouse nucleus accumbens during implantation of the stimulating electrodes. The higher the level of stimulated dopamine release during electrode impl... | ['Animals', 'Biomarkers', 'Dopamine', 'Electrodes, Implanted', 'Electrophysiology', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Neural Pathways', 'Nucleus Accumbens', 'Presynaptic Terminals', 'Reward', 'Self Stimulation', 'Synaptic Transmission', 'Ventral Tegmental Area'] | 17,632,281 | [['B01.050'], ['D23.101'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E07.305.250.319', 'E07.695.202'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A08... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Serum and tissue concentrations after a single dose of cefaclor]. | Serum and tissue concentrations of cefaclor were determined a total of 155 and 96 times respectively in 16 volunteers after a single dose of 1 g. At this dosage peak concentrations of 13.5, 14.5 and 13.4 mcg/ml were measured after 60, 90 and 120 minutes respectively. Tissues in which concentrations were measured includ... | ['Bacteria', 'Bone and Bones', 'Cefaclor', 'Cephalexin', 'Fascia', 'Muscles', 'Skin', 'Tissue Distribution'] | 511,343 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of oral clonidine on the vascular effects of stressful mental arithmetic in menopausal women. | The effects of 6 weeks of oral clonidine hydrochloride (0.05 mg b.i.d.) on the cardiovascular response to stressful mental arithmetic (SMA) were studied in menopausal women. There was no significant alteration in resting limb blood flow after oral clonidine. The rise in forearm blood flow during SMA was, however, great... | ['Adult', 'Blood Flow Velocity', 'Clonidine', 'Female', 'Forearm', 'Hand', 'Humans', 'Mathematics', 'Menopause', 'Middle Aged', 'Problem Solving', 'Stress, Psychological'] | 2,455,166 | [['M01.060.116'], ['E01.370.370.130', 'G09.330.380.630.080'], ['D03.383.129.308.436.500'], ['A01.378.800.585'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['G08.686.157.500', 'G08.686.841.249.500'], ['M01.060.116.630'], ['F02.463.425.725', 'F02.463.785.810'], ['F01.145.126.990', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
The motor cortex and the coding of force. | The relation of cellular activity in the motor cortex to the direction of two-dimensional isometric force was investigated under dynamic conditions in monkeys. A task was designed so that three force variables were dissociated: the force exerted by the subject, the net force, and the change in force. Recordings of neur... | ['Animals', 'Electrophysiology', 'Haplorhini', 'Isometric Contraction', 'Motor Activity', 'Motor Cortex', 'Motor Neurons'] | 1,609,282 | [['B01.050'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.988.400'], ['G11.427.494.472'], ['F01.145.632', 'G11.427.410.698'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['A08.675.655.500', 'A11.671.655.500']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental brain tumors and edema in rats. I. Histology and cytology of tumors. | In this study an experimental intracerebral tumor has been investigated with special consideration of structures, which may be involved in edema production and/or resolution. For this purpose a cloned tumor cell line (RG1 2.2) has been injected stereotactically into the brain of BD-IX rats. The tumor has some character... | ['Animals', 'Brain Edema', 'Brain Neoplasms', 'Neoplasm Transplantation', 'Neoplasms, Experimental', 'Rats'] | 7,315,198 | [['B01.050'], ['C10.228.140.187'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E05.624'], ['C04.619', 'E05.598.500.496'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of 2-amino-4,5-dichlorophenol (2A45CP) in vitro toxicity in renal cortical slices from male Fischer 344 rats. | 2-Amino-4,5-dichlorophenol (2A45CP) is a major, aromatic ring hydroxylated metabolite of the renal toxicant, 3,4-dichloroaniline. 3,4-Dichloroaniline is nephrotoxic with primary damage located to the proximal tubules. The purpose of this study was to first characterize the in vitro toxicity of 2A45CP in renal cortical ... | ['Animals', 'Ascorbic Acid', 'Biotransformation', 'Cell Survival', 'Chlorophenols', 'Dithiothreitol', 'Gluconeogenesis', 'Glutathione', 'In Vitro Techniques', 'Kidney Cortex', 'Kinetics', 'L-Lactate Dehydrogenase', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Oxidative Stress', 'Rats', 'Rats, Inbred F344'] | 11,882,351 | [['B01.050'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['G04.346'], ['D02.455.426.559.389.261.190', 'D02.455.426.559.389.657.190'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['G02.111.158.500', 'G03.191.500'], ['D12.644.456.448'], ['E05.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunohistochemical detection of oestrogen receptors in ductal carcinoma in situ of the breast. | The expression of oestrogen receptor (ER) protein in invasive carcinoma of the breast and its clinical significance has been extensively evaluated. Little information is available regarding ER expression in ductal carcinoma in situ (DCIS). In this study, 46 formalin-fixed, paraffin-embedded tissue specimens of mammogra... | ['Adult', 'Aged', 'Antibodies, Monoclonal', 'Breast Neoplasms', 'Carcinoma in Situ', 'Carcinoma, Ductal, Breast', 'Carcinoma, Intraductal, Noninfiltrating', 'Female', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'Receptors, Estrogen'] | 9,005,143 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.240'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['C04.557.470.200.025.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of species distribution and risk factors of candidemia: a multicenter case-control study. | This study was planned to determine the risk factors of candidemia, and the most common Candida species causing bloodstream infections. A case-control study which included adult patients was conducted over a 1-year period at tertiary-care educational hospitals in Turkey. A total of 83 candidemia episodes were identifie... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Candida', 'Candidemia', 'Case-Control Studies', 'Female', 'Hospitals, University', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Turkey', 'Young Adult'] | 20,662,635 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['C01.150.703.160.175.500', 'C01.150.703.492.500.500', 'C01.757.360.150', 'C23.550.470.790.500.360.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.50... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's disease. | BACKGROUND & AIMS: In the United States, the use of abdominopelvic computed tomography (APCT) by emergency departments for patients with abdominal pain has increased, despite stable admission rates and diagnosis requiring urgent intervention. We proposed that trends would be similar for patients with Crohn's disease (C... | ['Abdominal Pain', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Crohn Disease', 'Cross-Sectional Studies', 'Emergency Medical Services', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Pelvis', 'Radiography, Abdominal', 'Retrospective Studies', 'Tomography, X-Ray Computed', 'United States', 'Youn... | 21,946,122 | [['C23.888.592.612.054', 'C23.888.821.030'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N02.421.297'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.9... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Skin cancer in kidney transplant recipients: incidence and association with clinical and demographic factors]. | INTRODUCTION AND OBJECTIVES: Organ transplanted recipients have a higher risk of non melanoma skin cancer. Our objectives were to determine incidence of skin cancer and search for associations with clinical or demographic factors in a series of kidney transplant recipients.MATERIALS AND METHODS: A prospective study wit... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Incidence', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Prospective Studies', 'Risk Factors', 'Skin Neoplasms', 'Young Adult'] | 23,809,743 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Medially-stabilized total knee arthroplasty does not alter knee laxity and balance in cadaveric knees. | Instability after total knee arthroplasty (TKA) can lead to suboptimal outcomes and revision surgery. Medially-stabilized implants aim to more closely replicate normal knee motion than other implants following TKA, but no study has investigated knee laxity (motion under applied loads) and balance (i.e., difference in v... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Knee', 'Female', 'Humans', 'Joint Instability', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Middle Aged'] | 30,456,909 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.521'], ['A02.835.583.475'], ['E07.695.400.410'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Persistent organic pollutant concentrations in fledglings of two arctic seabird species. | Persistent organic pollutants (POPs) and stable isotopes were measured in muscle from fledglings of two arctic seabird species, Northern fulmar (Fulmarus glacialis) and Black-legged kittiwakes (Rissa tridactyla). The purpose was to compare POP concentrations between species, in an age class that is highly vulnerable to... | ['Animals', 'Arctic Regions', 'Birds', 'Charadriiformes', 'Environmental Monitoring', 'Environmental Pollutants', 'Environmental Pollution'] | 24,121,265 | [['B01.050'], ['Z01.208'], ['B01.050.150.900.248'], ['B01.050.150.900.248.150'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['N06.850.460']] | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Complex coordination of multi-scale cellular responses to environmental stress. | Cells and organisms are regularly exposed to a variety of stresses, and effective responses are a matter of survival. The article describes a multi-scale experimental and dynamical modeling analysis that clearly indicates concerted stress control in different temporal and organizational domains, and a strong synergy be... | ['Magnetic Resonance Spectroscopy', 'Models, Biological', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Stress, Physiological', 'Temperature'] | 21,088,798 | [['E05.196.867.519'], ['E05.599.395'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'], ['G07.775'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Eighteen-month follow-up on the treatment of urinary schistosomiasis with a single dose of metrifonate. | Egg excretion of school children with urinary schistosomiasis treated with a single 10 mg/kg dose of metrifonate was monitored over a period of 18 months. At 18 months 68.8% of infected children showed a greater than 90% reduction in egg excretion and 23.7% had ceased excreting eggs. During the study period 25% of chil... | ['Parasite Egg Count', 'Schistosomiasis', 'Time Factors', 'Trichlorfon', 'Urine'] | 4,025,687 | [['E01.370.225.932.600', 'E05.200.932.600'], ['C01.610.335.865.859', 'C01.920.922'], ['G01.910.857'], ['D02.705.429.937'], ['A12.207.927']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
["And when the patient becomes silent in his pain..." The medical consultation and its integral significance]. | The medical dialogue constitutes the basis of every doctor-patient relationship and it consists of more parts. The diagnostical dialogue comprises of a symptome-oriented and of a problem-oriented part. In the symptom-oriented part there have to be as many as possible symptoms systematically ascertained to come to a dia... | ['Communication', 'Female', 'Humans', 'Male', 'Physician-Patient Relations', 'Problem Solving', 'Psychotherapy', 'Suicide'] | 8,900,881 | [['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F02.463.425.725', 'F02.463.785.810'], ['F04.754'], ['F01.145.126.980.875', 'I01.880.735.856']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Intractable pain--the present position. | The broad changes that have occurred in the treatment of intractable pain are considered. There is a new understanding of the anatomy and physiology of pain pathways and pain appreciation. Thus gate control theory, the spinal laminae, and the descending inhibitory pain pathway through the raphe nuclei are discussed in ... | ['Electrocoagulation', 'Humans', 'Injections, Spinal', 'Narcotics', 'Pain, Intractable', 'Phenols', 'Pituitary Gland', 'Radio Waves', 'Research', 'State Medicine', 'United Kingdom'] | 6,894,676 | [['E02.154.402', 'E04.014.170.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.580'], ['D27.505.696.277.600', 'D27.505.696.663.850.014.760', 'D27.505.954.427.040.550', 'D27.505.954.427.210.600'], ['C23.888.592.612.776'], ['D02.455.426.559.389.657'], ['A06.300.747', 'A06.688.357.750', 'A08.186.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex. | The IL-6 signaling complex is described as a hexamer, formed by the association of two IL-6·IL-6 receptor (IL-6R)·gp130 trimers, with gp130 being the signal transducer inducing cis- and trans-mediated signaling via a membrane-bound or soluble form of the IL-6R, respectively. 25F10 is an anti-mouse IL-6R mAb that binds ... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Cytokine Receptor gp130', 'Female', 'Genetic Complementation Test', 'Humans', 'Interleukin-6', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Mice, Knockout', 'Models, Molecular', 'Molecular Sequence Data', 'Multiprotein Complexes', 'NIH 3T3 Cell... | 26,363,066 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.543.750.705.852.420.400.500', 'D12.776.543.750.705.852.420.560.249', 'D12.776.543.750.705.852.555.600.500', 'D12.776.543.750.705.852.583.500', 'D12.776.543.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Kinetic study of an enzyme-catalysed reaction in the presence of novel irreversible-type inhibitors that react with the product of enzymatic catalysis. | In the present paper a kinetic study is made of the behaviour of a Michaelis-Menten enzyme-catalysed reaction in the presence of irreversible inhibitors rendered unstable in the medium by their reaction with the product of enzymatic catalysis. A general mechanism involving competitive, non-competitive, uncompetitive an... | ['Binding, Competitive', 'Catalysis', 'Enzyme Inhibitors', 'Enzymes', 'Kinetics', 'Mathematics', 'Protein Binding'] | 7,833,851 | [['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G02.130'], ['D27.505.519.389'], ['D08.811'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['G02.111.679', 'G03.808']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Standardization of allergen extracts by inhibition of RAST, skin test, and chemical composition. | Five allergen extracts of Dermatophagoides pteronyssinus, Lolium perenne, Alternaria tenuis, Aspergillus fumigatus and Cladosporium herbarum, obtained from four different manufacturers, were examined by inhibition of RAST, content of protein and carbohydrate, contents of phosphorylcholine (Pc) and tridacnin reactive co... | ['Allergens', 'Alternaria', 'Animals', 'Aspergillus fumigatus', 'Chemical Phenomena', 'Chemistry', 'Cladosporium', 'Dose-Response Relationship, Immunologic', 'Humans', 'Mites', 'Poaceae', 'Radioallergosorbent Test', 'Skin Tests'] | 7,004,662 | [['D23.050.063'], ['B01.300.381.075'], ['B01.050'], ['B01.300.381.081.295'], ['G02'], ['H01.181'], ['B01.300.381.200'], ['G12.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.166.132.419'], ['B01.650.940.800.575.912.250.822'], ['E01.370.225.812.735.830', 'E05.200.812.735.830', 'E05.478.566.380.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification and characterization of the Tuber borchii D-mannitol dehydrogenase which defines a new subfamily within the polyol-specific medium chain dehydrogenases. | A novel NADP(+)-dependent D-mannitol dehydrogenase and the corresponding gene from the plant symbiotic ascomycete fungus Tuber borchii was identified and characterized. The enzyme, called TbMDH, is a homotetramer with two zinc atoms per subunit. It catalyzed both D-fructose reduction and D-mannitol oxidation, although ... | ['Amino Acid Sequence', 'Ascomycota', 'Cloning, Molecular', 'L-Iditol 2-Dehydrogenase', 'Mannitol Dehydrogenases', 'Molecular Sequence Data', 'NADP', 'Phylogeny'] | 17,317,242 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.300.107'], ['E05.393.220'], ['D08.811.682.047.150.700.475'], ['D08.811.682.047.150.700.649'], ['L01.453.245.667'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Spectroscopic imaging (1H-2D-CSI) of the prostate: sequence optimization and correlation with histopathological results]. | PURPOSE: Methodological optimization of a 1H MR spectroscopic imaging sequence (1H-2D-CSI) and evaluation of its potential to diagnose prostate cancer as validated by histopathological maps.METHODS: The prostates of 18 patients were evaluated by 1H-MR-CSI (voxel dimension: 1 cm3) at 1.5 Tesla. This sequence was additio... | ['Aged', 'Choline', 'Citrates', 'Creatine', 'Diagnosis, Differential', 'Humans', 'Magnetic Resonance Spectroscopy', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prostate', 'Prostate-Specific Antigen', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'Reproducibility of Results'] | 10,962,989 | [['M01.060.116.100'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['D02.241.081.901.434'], ['D02.078.370.280', 'D12.125.373'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['M01.060.116.630'], ['E01.789.625'], ['A05.360.444.575', 'A10.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. | The identification of genetic mutations responsible for rare familial forms of Parkinson's disease (PD) have provided tremendous insight into the molecular pathogenesis of this disorder. Mutations in the DJ-1 gene cause autosomal recessive early onset PD in two European families. A Dutch kindred displays a large homozy... | ['Autoantigens', 'Blotting, Northern', 'Blotting, Western', 'Cell Line, Tumor', 'Cycloheximide', 'Electrophoresis, Gel, Pulsed-Field', 'Humans', 'In Vitro Techniques', 'Intracellular Signaling Peptides and Proteins', 'Leucine', 'Methionine', 'Mutation, Missense', 'Oncogene Proteins', 'Parkinsonian Disorders', 'Phenylal... | 14,713,311 | [['D23.050.422'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.383.621.808.240'], ['E05.196.401.220', 'E05.301.300.220'], ['B01.050.150.900.649.313.988.400.112.400... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integrating Molecular Biology and Bioinformatics Education. | Combined awareness about the power and limitations of bioinformatics and molecular biology enables advanced research based on high-throughput data. Despite an increasing demand of scientists with a combined background in both fields, the education of dry and wet lab subjects are often still separated. This work describ... | ['Computational Biology', 'Female', 'Humans', 'Male', 'Molecular Biology'] | 31,145,692 | [['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Anorectal malformation and Down's syndrome in monozygotic twins. | Anorectal malformation (ARM) can be divided in high, intermediate, and low forms according to the level of termination of the rectum in relation to the pubococcygeal and ischiatic lines. Patients with Down's syndrome have a high incidence of gastrointestinal anomalies, such as tracheoesophageal fistula, duodenal obstru... | ['Abnormalities, Multiple', 'Anal Canal', 'Diseases in Twins', 'Down Syndrome', 'Humans', 'Infant, Newborn', 'Male', 'Rectum'] | 19,231,514 | [['C16.131.077'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['C23.550.291.750'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A03.556.124.526.767', 'A03.556.249.249.767']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Unsaturated fatty acids in diabetes mellitus]. | The following unsaturated fatty acids were examined in the serum and in the high density lipoproteins of 38 patients with diabetes mellitus type Il and 20 healthy controls: linolic, linolenic, eicosandienoic, eicosanetrienoic, arachidonic and eicosanepentaenoic. In decompensates diabetes mellitus a decrease of linoleni... | ['Aged', 'Blood Glucose', 'Chronic Disease', 'Diabetes Mellitus, Type 2', 'Fatty Acids, Unsaturated', 'Female', 'Humans', 'Lipoproteins, HDL', 'Male', 'Middle Aged'] | 2,741,444 | [['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C23.550.291.500'], ['C18.452.394.750.149', 'C19.246.300'], ['D10.251.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.432', 'D12.776.521.479'], ['M01.060.116.630']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Penetration and entrapment of large particles in erythrocytes by electrical breakdown techniques. | Human erythrocytes suspended in isotonic solutions were subjected to haemolysis by application of an electric field pulse to the cell suspension. The field strengths used were 12 and 16kV/cm, respectively; the pulse duration 40 microseconds. The lysed cells showed resealing properties. The permeability change of the me... | ['Cell Membrane Permeability', 'Cells, Cultured', 'Electricity', 'Erythrocyte Membrane', 'Erythrocytes', 'Ferritins', 'Hemolysis', 'Humans', 'Isotonic Solutions', 'Latex', 'Microspheres', 'Osmosis', 'Particle Size'] | 689,250 | [['G03.143.335', 'G04.175'], ['A11.251'], ['G01.358.500.249'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.776.498'... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Characterization of the biotin transport system in Saccharomyces cerevisiae. | The characteristics of the biotin transport mechanism of Saccharomyces cerevisiae were investigated in nonproliferating cells. Microbiological and radioisotope assays were employed to measure biotin uptake. The vitamin existed intracellularly in both free and bound forms. Free biotin was extracted by boiling water. Chr... | ['Autoradiography', 'Biological Transport, Active', 'Biotin', 'Carbon Isotopes', 'Chromatography', 'Depression, Chemical', 'Glucose', 'Hydrogen-Ion Concentration', 'Iodoacetates', 'Saccharomyces', 'Stimulation, Chemical', 'Temperature', 'Time Factors'] | 5,354,931 | [['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['G03.143.310'], ['D03.383.129.308.080', 'D08.211.096'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.181'], ['G07.690.773.750'], ['D09.947.875.359.448'], ['G02.300'], ['D02.241.081.018.487', 'D02.455.526.581.247'], ['B01.300.107.795.785', 'B01.300.930.705'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study. | Alcohol increases the risk of both hepatocellular carcinoma (HCC) and colorectal neoplasia. In this hospital-based case-control and retrospective cohort study, we sought to determine whether development of colorectal neoplasia increases the risk of HCC in patients with alcoholic liver disease (ALD). In the phase I case... | ['Adult', 'Aged', 'Carcinoma, Hepatocellular', 'Case-Control Studies', 'Cohort Studies', 'Colorectal Neoplasms', 'Female', 'Humans', 'Liver Diseases, Alcoholic', 'Liver Neoplasms', 'Logistic Models', 'Male', 'Middle Aged', 'Non-alcoholic Fatty Liver Disease', 'Odds Ratio', 'Prognosis', 'Proportional Hazards Models', 'R... | 30,824,851 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.274.476.411.307', 'C06.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors influencing the measurement of closing volume. | The various factors influencing closing volume were studied by performing the single-breath N2 test on 9 healthy nonsmokers. Time of day, day of the week, and preceding volume history had no effect on either closing volume or alveolar plateau. Slow inspiratory flow resulted in larger ratio of closing volume to vital ca... | ['Adult', 'Airway Resistance', 'Female', 'Forced Expiratory Volume', 'Humans', 'Lung Volume Measurements', 'Male', 'Nitrogen', 'Plethysmography, Whole Body', 'Pulmonary Ventilation', 'Spirometry', 'Time Factors', 'Vital Capacity'] | 1,137,243 | [['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.386.700.485'], ['D01.268.604', 'D01.362.625'], ['E01.370.370.610.805', 'E01.370.386.700.615'], ['E01.370.386.700.660', 'G09.772.650'], ['E01.370.386.700.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells. | We have previously reported that antibodies to phosphotyrosine recognize the phosphorylated forms of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors (Zippel et al., Biochim. Biophys. Acta 881:54-61, 1986, and Sturani et al., Biochem. Biophys. Res. Commun. 137:343-350, 1986). In this re... | ['Carcinoma, Squamous Cell', 'Electrophoresis, Polyacrylamide Gel', 'ErbB Receptors', 'Fibroblasts', 'Humans', 'Hydrogen-Ion Concentration', 'Immunoassay', 'Kinetics', 'Phosphorylation', 'Protein Kinase C', 'Trypsin', 'Tumor Cells, Cultured', 'Tyrosine'] | 3,367,910 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.196.401.402', 'E05.301.300.319'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.478.566', 'E05.601.470'], ['G01.374.661', 'G02.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transfusion of platelet concentrates--clinical evaluation of two preparations. | The aim of this study was to compare the clinical effect of transfusion of platelet concentrates (PC) prepared from pooled buffy coats (BC) and PCs collected from a single donor (SD) by an apheresis technique. The influence of storage time and various clinical conditions was also studied. Thirty-two patients suffering ... | ['Adolescent', 'Adult', 'Aged', 'Blood Coagulation', 'Blood Component Removal', 'Blood Preservation', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Platelet Count', 'Platelet Transfusion', 'Time Factors'] | 8,982,294 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G09.188.390.150'], ['E02.120'], ['E02.792.833.230', 'E05.760.833.230'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Studies on MDA and MDA/MDAa in patients with retinitis pigmentosa]. | With fluorimetry, the concentration of malondialdehyde (MDA) and the ratio of MDA before and after the blood platelets activated (MDA/MDAa) were determined in patients with retinitis pigmentosa (RP). The results showed the above two parameters were statistically higher than those of the normal controls, which indicated... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Middle Aged', 'Platelet Activation', 'Retinitis Pigmentosa'] | 7,774,696 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['D02.047.700'], ['M01.060.116.630'], ['G09.188.390.600'], ['C11.270.684', 'C11.768.585.658.500', 'C16.320.290.684']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Topiramate in the treatment of chronic migraine. | The purpose of this study was to evaluate the efficacy of topiramate in the treatment of chronic migraine. This was a double-blind, randomized, placebo controlled, parallel-group study. Patients suffering from chronic migraine with analgesic overuse were randomly assigned in a 1 : 1 ratio to receive topiramate or place... | ['Adult', 'Analgesics', 'Chi-Square Distribution', 'Chronic Disease', 'Confidence Intervals', 'Double-Blind Method', 'Female', 'Fructose', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Multivariate Analysis', 'Odds Ratio', 'Topiramate'] | 14,510,929 | [['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C23.550.291.500'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Using site assessment and risk analysis to plan and build disaster-resistant programs and facilities. | Research animals need protection from the catastrophic losses that can occur during disasters. The best method of protecting animals is to house them in facilities that have been reinforced using disaster-resistant construction methods. The authors explain the use of site-specific risk analysis to determine the proper ... | ['Animals', 'Animals, Laboratory', 'Communication', 'Disaster Planning', 'Disasters', 'Facility Design and Construction', 'Housing, Animal', 'Risk Assessment'] | 12,545,184 | [['B01.050'], ['B01.050.050.199'], ['F01.145.209', 'L01.143'], ['N06.230.100.035'], ['N06.230.100'], ['J01.086.339', 'N02.278.200'], ['J03.340.250', 'N06.230.150.360.250'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Heart fatty acid binding protein in the rapid evaluation of myocardial damage following valve replacement surgery. | BACKGROUND: Myocardial damage occurs following valve replacement surgery. We estimated the value of heart fatty acid binding protein (H-FABP) in these patients.METHODS: Sixty elected patients were enrolled and distributed into single (group A) and double (group B) valve replacement groups. The clinical data were outlin... | ['Adult', 'Biomarkers', 'Cardiac Output, Low', 'Cardiopulmonary Bypass', 'Carrier Proteins', 'Creatine Kinase', 'Creatine Kinase, MB Form', 'Fatty Acid-Binding Proteins', 'Female', 'Heart Valves', 'Humans', 'Isoenzymes', 'Male', 'Middle Aged', 'Myocardium', 'Time Factors', 'Troponin I'] | 15,936,311 | [['M01.060.116'], ['D23.101'], ['C14.280.148', 'C23.888.192'], ['E04.292.413'], ['D12.776.157'], ['D08.811.913.696.640.150'], ['D08.811.913.696.640.150.625'], ['D12.776.157.170'], ['A07.541.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['M01.060.116.630'], ['A02.633.580', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A phase II evaluation of weekly paclitaxel plus carboplatin in advanced urothelial cancer. | This Phase II trial was designed to evaluate the overall objective response rate, complete response rate, efficacy, and safety of weekly paclitaxel (Taxol) and carboplatin (Paraplatin) in the treatment of advanced urothelial carcinoma. Thirty-three patients with measurable, unresectable, stage III-IV carcinoma of the u... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Ulcer Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Asthenia', 'Carboplatin', 'Carcinoma', 'Combined Modality Therapy', 'Dexamethasone', 'Diphenhydramine', 'Disease-Free Survival', 'Drug Administration Schedule', 'Female', 'Gastrointestinal Diseases', 'Hematolo... | 15,493,358 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.483.203'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C23.888.089'], ['D02.257.125'], ['C04.557.470.200'], ['E02.186'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D02.092.471.320', 'D02.455.426.559.389.115.250... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Systematic Relations between Affective and Sensory Material Dimensions in Touch. | Participants manually explored 47 solid, fluid, and granular materials and rated them according to a list of sensory and affective attributes. In principal component analyses (PCA) of sensory ratings, we extracted six dimensions: Fluidity, Roughness, Deformability, Fibrousness, Heaviness, and Granularity. PCAs on affec... | ['Adolescent', 'Adult', 'Emotions', 'Female', 'Hand', 'Humans', 'Male', 'Principal Component Analysis', 'Touch Perception', 'Young Adult'] | 29,994,318 | [['M01.060.057'], ['M01.060.116'], ['F01.470'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.562'], ['F02.463.593.894'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. | Previous studies have detected gamma delta T cells in multiple sclerosis and experimental allergic encephalomyelitis (EAE) lesions but their role remains obscure. In the present study, we assessed gamma delta T cell dynamics and distribution in spleen and central nervous system (CNS) from mice with relapsing-remitting ... | ['Acute Disease', 'Animals', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Lymphocyte Count', 'Lymphocyte Depletion', 'Mice', 'Mice, Inbred Strains', 'Receptors, Antigen, T-Cell, gamma-delta', 'Recurrence', 'Spinal Cord', 'T-Lymphocyte Subsets'] | 8,752,949 | [['C23.550.291.125'], ['B01.050'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['E01.370.225.500.195.107.595.500', 'E01.370.225.625.107.595.500', 'E05.200.500.195.107.595.500', 'E05.200.625.107.595.500', 'E05.242.195.107.595.500', 'G04.140.107.595.500... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Notched audiograms and noise exposure history in older adults. | OBJECTIVE: Using data from a population-based cohort study, we compared four published algorithms for identifying notched audiograms and compared their resulting classifications with noise exposure history.DESIGN: Four algorithms: (1) , (2) , (3) , and (4) were used to identify notched audiograms. Audiometric evaluatio... | ['Aged', 'Aged, 80 and over', 'Algorithms', 'Audiometry, Pure-Tone', 'Auditory Threshold', 'Cross-Sectional Studies', 'Female', 'Firearms', 'Follow-Up Studies', 'Hearing Loss, Noise-Induced', 'Hobbies', 'Humans', 'Male', 'Middle Aged', 'Noise', 'Occupational Diseases', 'Odds Ratio', 'Pitch Discrimination', 'Regression ... | 19,633,561 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['E01.370.382.375.060.055'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['J01.637.870.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomen... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Novel mutation in STXBP1 gene in a patient with non-lesional Ohtahara syndrome. | INTRODUCTION: Ohtahara syndrome (OS, OMIM#308350, ORPHA1934) is an early-onset epileptic encephalopathy (EOEE) characterised by spasms, intractable seizures, suppression-burst pattern on the electroencephalogram, and severe psychomotor retardation. Mutations in STXBP1 -a gene that codes for syntaxin binding protein 1 a... | ['Child, Preschool', 'Exons', 'Humans', 'Intellectual Disability', 'Magnetic Resonance Imaging', 'Male', 'Munc18 Proteins', 'Mutation', 'Spasms, Infantile'] | 25,631,041 | [['M01.060.406.448'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['E01.370.350.825.500'], ['D12.776.543.990.587'], ['G05.365.590'], ['C10.228.140.490.375.760', 'C10.228.140.490.493.875']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer. | Angiogenesis is a critical event in the development, progression, and spread of various human cancers, including lung cancer. Molecular mechanisms that underlie the complex regulation of angiogenic processes are poorly understood. However, an increasing body of evidence indicates miRNAs as important regulators of tumor... | ['Carcinoma, Non-Small-Cell Lung', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Lung Neoplasms', 'MicroRNAs', 'Neovascularization, Pathologic'] | 23,029,111 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Relationship Between Worry and Dimensions of Anxiety Symptoms in Children and Adolescents. | BACKGROUND: Worry is a common feature across many anxiety disorders. It is important to understand how and when worry presents from childhood to adolescence to prevent long-term negative outcomes. However, most of the existing studies that examine the relationship between worry and anxiety disorders utilize adult sampl... | ['Adolescent', 'Anxiety', 'Anxiety Disorders', 'Anxiety, Separation', 'Child', 'Depression', 'Humans', 'Male', 'Phobia, Social', 'Psychometrics', 'Surveys and Questionnaires'] | 27,852,349 | [['M01.060.057'], ['F01.470.132'], ['F03.080'], ['F03.080.300', 'F03.625.047'], ['M01.060.406'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.080.725.500'], ['F04.711.780'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distribution of lymphocyte subsets in the large intestinal lymphoid follicles of lambs. | The phenotypes of lymphocytes in the large intestinal patches (LIP) of lambs were examined by flow cytometry and immunohistology, using a panel of monoclonal antibodies (mAb), and compared to those found in the jejunal (JPP) and ileal Peyer's patches (IPP). T-cell markers were detected on 25% of the LIP and JPP lymphoc... | ['Animals', 'Antigens, Surface', 'B-Lymphocytes', 'Colon', 'Immunoenzyme Techniques', 'Lymphocytes', 'Lymphoid Tissue', 'Rectum', 'Sheep', 'T-Lymphocytes'] | 2,199,370 | [['B01.050'], ['D23.050.301'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. | RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3æ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck and ZAP-70 to the imm... | ['Animals', 'CD3 Complex', 'Female', 'HEK293 Cells', 'Humans', 'Immunoblotting', 'Intracellular Space', 'Jurkat Cells', 'Lymphocyte Specific Protein Tyrosine Kinase p56(lck)', 'Male', 'Mice', 'Mice, 129 Strain', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Transgenic', 'Phosphorylation', 'Protein Binding', 'Receptors... | 21,103,055 | [['B01.050'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['A10.082.750', 'A11.284.430'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['D08.811.913.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of serum and plasma leukotriene B4 levels in normal and asthmatic subjects. | BACKGROUND: Leukotriene B4 (LTB4) serum and plasma concentrations were reported to be higher in some asthmatic patients than in normal subjects; however, reported LTB4 concentrations in normal subjects vary widely. One study suggested that blood clotting causes the increased LTB4 concentration.OBJECTIVE: To determine w... | ['Adult', 'Asthma', 'Blood Coagulation', 'Female', 'Humans', 'Leukotriene B4', 'Male', 'Middle Aged'] | 7,583,855 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G09.188.390.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.251.355.255.100.450.411', 'D10.251.355.310.166.887.411', 'D23.469.050.175.450.415'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Marital satisfaction in couples with rheumatoid arthritis. | OBJECTIVE: To understand correlates of marital satisfaction in persons with rheumatoid arthritis (RA) and their spouses.METHODS: In a cross-sectional survey, 79 persons with RA and 78 spouses completed the Kansas Marital Satisfaction Scale, the revised Ways of Coping Questionnaire scales, and the Health Assessment Ques... | ['Adaptation, Psychological', 'Aged', 'Arthritis, Rheumatoid', 'Attitude to Health', 'Avoidance Learning', 'Conflict, Psychological', 'Cross-Sectional Studies', 'Educational Status', 'Fantasy', 'Female', 'Humans', 'Linear Models', 'Male', 'Marriage', 'Middle Aged', 'Models, Psychological', 'Personal Satisfaction', 'Qua... | 14,635,288 | [['F01.058'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['F01.100.150', 'N05.300.150'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.658.209'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N01.824.196'], ['F01.393.351', 'F02.463.1... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A novel way to manage trastuzumab cardiotoxicity. | PURPOSE: Trastuzumab is the most widely prescribed anti-HER2 humanized monoclonal antibody. Cardiac toxicity is the only limiting toxicity of trastuzumab and it is of particular concern in patients with complete response, since the drug needs to be stopped, with a risk of disease relapse. To date, no pharmacological da... | ['Antibodies, Monoclonal, Humanized', 'Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Cardiotoxicity', 'Drug Administration Schedule', 'Female', 'Humans', 'Middle Aged', 'Prognosis', 'Trastuzumab'] | 29,497,813 | [['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['C14.280.260', 'C23.550.161', 'C25.100.389', 'C26.733.266', 'G01.750.748.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cross-sectional and case-control analyses of the association of kidney function staging with adverse postoperative outcomes in general and vascular surgery. | OBJECTIVE: This study aimed to assess kidney dysfunction in general surgical patients and examine the effect on postoperative mortality and morbidity.BACKGROUND: An estimated 13% of the US population has chronic kidney disease (CKD), but awareness among patients and caregivers is lacking.METHODS: The American College o... | ['Aged', 'Analysis of Variance', 'Case-Control Studies', 'Chi-Square Distribution', 'Colectomy', 'Cross-Sectional Studies', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Kidney Function Tests', 'Logistic Models', 'Male', 'Middle Aged', 'Postoperative Complications', 'Predictive Value of Tests', 'Proportional Hazards ... | 23,478,526 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E04.210.219'], ['E05.318.372.500.875', 'N05.715.360.330.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ultrastructural mapping of a sperm plasma membrane autoantigen before and after the acrosome reaction. | The rabbit sperm plasma membrane autoantigen, RSA, is a zona binding protein that binds the spermatozoon to the zona pellucida both before and after the acrosome reaction. In the present study rabbit spermatozoa undergoing the acrosome reaction in vitro are described and monospecific polyclonal mouse anti-RSA and prote... | ['Acrosome', 'Animals', 'Autoantigens', 'Cell Membrane', 'Female', 'Fluorescent Antibody Technique', 'Freeze Fracturing', 'Immunohistochemistry', 'Male', 'Microscopy, Electron', 'Rabbits', 'Sperm Capacitation', 'Sperm-Ovum Interactions', 'Spermatozoa', 'Zona Pellucida'] | 3,058,567 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['B01.050'], ['D23.050.422'], ['A11.284.149'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['E01.370.225.500.620.620.260', 'E01.370.225... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling. | Mammalian phosphoglycolate phosphatase (PGP, also known as AUM or glycerol-3-phosphate phosphatase) is a small molecule-directed phosphatase important for metabolite repair and lipid metabolism. Although PGP was first characterized as an enzyme involved in epidermal growth factor (EGF) signaling, PGP protein substrates... | ['Cell Line', 'Epidermal Growth Factor', 'Humans', 'Phosphatidylinositol 4,5-Diphosphate', 'Phospholipase C gamma', 'Phosphoric Monoester Hydrolases', 'Protein Kinase C', 'Signal Transduction', 'Triglycerides'] | 29,524,543 | [['A11.251.210'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.570.755.375.760.400.942.625.900'], ['D08.811.277.352.640.700.700.562.750', 'D12.644.360.571.750', 'D12.776.476.556.750'], ['D08.811.277.352.650'], ['D08.811.913.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New procedure of bronchoalveolar lavage using a balloon catheter in diffuse lung diseases. | BACKGROUND: Various procedures for bronchoalveolar lavage (BAL) have been developed. BAL needs a wedge between the bronchoscope and the inner surface of the bronchus. The feasibility of performing BAL at the targeted position cannot be determined until immediately before the procedure. We examined BAL performed using a... | ['Bronchoalveolar Lavage', 'Humans', 'Lung Diseases'] | 31,668,934 | [['E05.927.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. | OBJECTIVES: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials.BACKGROUND: There is growing interest in using magnetic resonance imaging (MRI) ... | ['Adult', 'Aged', 'Animals', 'Clinical Protocols', 'Contrast Media', 'Dogs', 'Dose-Response Relationship, Drug', 'Female', 'Gadolinium DTPA', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prospective Studies', 'Risk Assessment', 'Time Factors'] | 16,697,321 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['E02.183', 'N05.715.360.330.125'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Selection of the imaging modalities for diagnosis of renal trauma: experience with 74 cases]. | OBJECTIVE: To explore the diagnostic approaches and values of the imaging modalities for traumatic renal injuries.METHODS: The clinical records of 74 cases of renal trauma treated in Nanfang Hospital were retrospectively reviewed to assess the diagnostic value of intravenous urography (IVU), type B ultrasonography and ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed', 'Ultrasonography', 'Urography', 'Wounds and Injuries'] | 12,919,927 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850'], ['... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The (mis)matching of resources and assessed need in remote Aboriginal community aged care. | AIM: To examine processes of aged-care needs assessment for Aboriginal people in remote central Australia to assist development of appropriate models of aged care.METHOD: A qualitative study involving 11 semistructured interviews with aged-care assessors and two focus groups with Aboriginal community members.RESULTS: T... | ['Aged', 'Australia', 'Female', 'Focus Groups', 'Health Services Accessibility', 'Health Services Needs and Demand', 'Health Services for the Aged', 'Health Services, Indigenous', 'Healthcare Disparities', 'Humans', 'Male', 'Oceanic Ancestry Group', 'Qualitative Research'] | 25,482,529 | [['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['N04.590.374.350', 'N05.300.430'], ['N03.349.380.420', 'N05.300.450'], ['N02.421.320'], ['N02.421.330'], ['N04.590.374.380', 'N05.300.493'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M0... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Toward a practical and waste-free synthesis of thioureas in water. | An operationally simple and entirely green protocol for the synthesis of thiourea derivatives by the reaction of carbon disulfide with primary amines in pure water is developed. This reaction is a highly atom-economic process for production of highly pure, hindered thioureas without any catalyst and tedious work-up. | ['Drug Discovery', 'Green Chemistry Technology', 'Thiourea', 'Water'] | 20,180,020 | [['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['J01.897.360'], ['D02.065.950.898', 'D02.886.904'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Supplementary instrument for lens removal (author's transl)]. | A combination of a sponge holder and a squint hook is described as a supplementary instrument for intracapsular lens cryo-extraction with this instrument. Quick changes of manipulations during lens removal and other surgical manoeuvres are possible. | ['Cryosurgery', 'Humans', 'Lens, Crystalline', 'Surgical Instruments', 'Time Factors'] | 916,613 | [['E04.014.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.060.500'], ['E07.858.700'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abdominal aortic aneurysm rupture is not associated with an up-regulation of inflammation within the aneurysm wall. | BACKGROUND: The nature of the inflammatory change within ruptured AAA has not been extensively reported. The aim of this study was to compare the inflammatory response in non-ruptured and ruptured aneurysms with emphasis on the site of rupture.METHODS: Non-rupture site biopsies were taken from the anterior aneurysm sac... | ['Aneurysm, Ruptured', 'Aortic Aneurysm, Abdominal', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Imidazoles', 'Immunohistochemistry', 'Inflammation Mediators', 'Interleukin-1beta', 'Lymphocyte Count', 'Quinolones', 'Radiography', 'Tumor Necrosis Factor-alpha', 'Up-Regulation'] | 20,537,568 | [['C14.907.055.185'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcutaneous Carbon Dioxide Monitoring with Reduced-Temperature Probes in Very Low Birth Weight Infants. | Background Obtaining blood gases in very low birth weight (VLBW) infants is an invasive procedure. Studies using transcutaneous carbon dioxide (tcPCO2) have reported variable skin complications with high-temperature probes. No enough data available on tcPCO2 monitoring using reduced-temperature probes (41°C). Objective... | ['Blood Gas Monitoring, Transcutaneous', 'Carbon Dioxide', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Very Low Birth Weight', 'Male', 'Partial Pressure', 'Prospective Studies', 'Reproducibility of Results', 'Temperature'] | 27,673,754 | [['E01.370.225.124.100.100.600.100', 'E01.370.370.380.600.100', 'E01.370.386.700.100.600.100', 'E05.200.124.100.100.600.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.600'], ['G01.374.715.714'], ['E05.318.372.500.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors influencing the use of frozen section analysis in adnexal masses. | OBJECTIVE: To determine the factors that influence the use of frozen section analysis in adnexal masses and the factors that predict malignancy.METHODS: The study participants were women scheduled for adnexal mass surgery in 11 hospitals between 2005 and 2009. Factors that potentially influenced the use of frozen secti... | ['Adnexal Diseases', 'CA-125 Antigen', 'Female', 'Frozen Sections', 'Genital Neoplasms, Female', 'Humans', 'Logistic Models', 'Membrane Proteins', 'Menopause', 'Multivariate Analysis', 'Retrospective Studies', 'Sensitivity and Specificity'] | 21,691,163 | [['C13.351.500.056'], ['D12.776.395.560.631.050', 'D23.050.285.050.225', 'D23.050.550.325.225', 'D23.101.140.075.225'], ['E01.370.225.500.620.530.160.260', 'E01.370.225.750.600.530.160.260', 'E05.200.500.620.530.160.260', 'E05.200.750.600.530.160.260'], ['C04.588.945.418', 'C13.351.937.418'], ['B01.050.150.900.649.313.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Antigens HLA-G, sHLA- G and sHLA- class I in reproductive failure. | It can be supposed that relation between HLA-G polymorphism and sHLA-G protein expression are associated with successful embryo implantation and pregnancy maintenance. The aim of the study was the estimation specific differences in expression of sHLA-G and sHLA- class I antigens in women with reproductive failure in co... | ['Abortion, Spontaneous', 'Alleles', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Genotype', 'HLA Antigens', 'HLA-G Antigens', 'Histocompatibility Antigens Class I', 'Humans', 'Infertility, Female', 'Leukocytes', 'Polymorphism, Genetic', 'Pregnancy', 'Pregnancy Trimester, First'] | 18,292,821 | [['C13.703.039', 'G08.686.784.769.496.125'], ['G05.360.340.024.340.030'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.380'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['D12.776.395.550.489.700', 'D12.776.543.550.439.700', 'D23.050.301.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorine-18 fluorodeoxyglucose-position emission tomography: a highly accurate imaging modality for the diagnosis of chronic musculoskeletal infections. | BACKGROUND: The noninvasive diagnosis of chronic musculoskeletal infections remains a challenge. Recent studies have indicated that fluorine-18 fluorodeoxyglucose-positron emission tomography is a highly accurate imaging technique and is significantly more accurate than the combination of a bone scan and a white blood-... | ['Adolescent', 'Adult', 'Aged', 'Chronic Disease', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Infections', 'Male', 'Middle Aged', 'Musculoskeletal Diseases', 'Osteomyelitis', 'Radiopharmaceuticals', 'Tomography, Emission-Computed'] | 11,379,733 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['M01.060.116.630'], ['C05'], ['C01.160.495', 'C05.116.165.495'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.410.650'], ['E01.370.350.350.800', 'E01.370.35... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A significant effect of the killer cell immunoglobulin-like receptor ligand human leucocyte antigen-C on fibrosis progression in chronic C hepatitis with or without liver transplantation. | BACKGROUND & AIMS: The interaction of killer cell immunoglobulin-like receptors with their human leucocyte antigen ligands drives the activation and inhibition of natural killer cells. Natural killer cells could be implicated in the development of liver fibrosis in chronic hepatitis C.METHODS: We analysed 206 non-trans... | ['Disease Progression', 'Female', 'Gene Frequency', 'Genotype', 'HLA-C Antigens', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Killer Cells, Natural', 'Liver', 'Liver Cirrhosis', 'Liver Transplantation', 'Logistic Models', 'Male', 'Middle Aged', 'Receptors, KIR', 'Switzerland'] | 26,717,049 | [['C23.550.291.656'], ['G05.330'], ['G05.380'], ['D12.776.395.550.489.600', 'D12.776.543.550.439.600', 'D23.050.301.500.100.600', 'D23.050.301.500.450.390', 'D23.050.705.552.100.600', 'D23.050.705.552.450.390'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study. | RATIONALE: The long-term respiratory sequelae of infants born extremely preterm (EP) and now graduating from neonatal intensive care remains uncertain.OBJECTIVES: To assess the degree of respiratory morbidity and functional impairment at 11 years in children born EP (i.e., at or less than 25 completed weeks of gestatio... | ['Asthma', 'Bronchial Hyperreactivity', 'Bronchodilator Agents', 'Bronchopulmonary Dysplasia', 'Case-Control Studies', 'Child', 'Cohort Studies', 'Follow-Up Studies', 'Forced Expiratory Flow Rates', 'Forced Expiratory Volume', 'Funnel Chest', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Multivariate Analysis', 'R... | 20,378,729 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C08.127.210'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['C08.381.520.750.500', 'C16.614.521.125'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human Brain Modeling with Its Anatomical Structure and Realistic Material Properties for Brain Injury Prediction. | Impairments of executive brain function after traumatic brain injury (TBI) due to head impacts in traffic accidents need to be obviated. Finite element (FE) analyses with a human brain model facilitate understanding of the TBI mechanisms. However, conventional brain FE models do not suitably describe the anatomical str... | ['Brain', 'Brain Injuries', 'Finite Element Analysis', 'Humans', 'Models, Neurological'] | 29,404,847 | [['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.642']] | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Office steroid injections of the larynx. | OBJECTIVE: Steroid injection into the larynx has been sporadically reported as helpful in benign lesions of the larynx. Its role in laryngology remains unclear. This study reviews the indications and results of 47 steroid injections in 34 patients in an office setting.METHODS: The authors conducted a retrospective revi... | ['Anti-Inflammatory Agents', 'Cicatrix', 'Cysts', 'Granuloma, Laryngeal', 'Humans', 'Injections, Intralesional', 'Laryngeal Diseases', 'Laryngoscopy', 'Methylprednisolone', 'Methylprednisolone Acetate', "Physicians' Offices", 'Polyps', 'Postoperative Complications', 'Retrospective Studies', 'Sarcoidosis', 'Stroboscopy'... | 17,003,727 | [['D27.505.954.158'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['C04.182', 'C23.300.306'], ['C08.280.400', 'C08.360.232', 'C08.618.846.414', 'C09.400.232', 'C23.550.382.968.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.430'], ['C08.360', 'C09.400'], ['E01.370.386.460', 'E01... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of feedback regarding urinary cotinine and brief tailored advice on home smoking restrictions among low-income parents of children with asthma: a controlled trial. | BACKGROUND: Since most smoker parents of children with asthma are unable to quit, an alternative measure that would reduce their children's exposure to environmental tobacco smoke (ETS) is to ban smoking in the home.METHODS: Compared with 136 usual-care controls, 128 intervention-group parents recruited from South Aust... | ['Adult', 'Asthma', 'Behavior Therapy', 'Biomarkers', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Cotinine', 'Creatinine', 'Feedback', 'Health Education', 'Humans', 'Infant', 'Parents', 'Smoking', 'Smoking Prevention', 'South Australia', 'Tobacco Smoke Pollution'] | 11,749,097 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['F04.754.137'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['D03.383.773.812.180'], ['D03.383.129.308.207'], ['L01.906.394.211'], ['I02.233.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. | BACKGROUND: The in vivo kinetics of nanoparticles is an essential to understand the hazard of nanoparticles. Here, the absorption, distribution, and excretion patterns of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles following oral administration were evaluated.METHODS: Nanoparticles were orally administer... | ['Administration, Oral', 'Animals', 'Body Burden', 'Body Weight', 'Drug Administration Schedule', 'Feces', 'Female', 'Intestinal Absorption', 'Male', 'Mass Spectrometry', 'Nanoparticles', 'Rats', 'Rats, Sprague-Dawley', 'Tissue Distribution', 'Titanium', 'Zinc Oxide'] | 23,531,334 | [['E02.319.267.100'], ['B01.050'], ['E05.799.638.231', 'N06.850.460.200'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E02.319.283'], ['A12.459'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Comparison of biochemical simulations using integrators derived from "Adomian" decomposition with traditional numerical methods. | Comparisons are made between some traditional numerical integrators and integration using "Adomian" power series solutions to the ordinary differential equations. These are initial investigations to determine the viability of their application to the simulation of large complex metabolic pathways. A small set of test e... | ['Computer Simulation', 'Enzymes', 'Evaluation Studies as Topic', 'Kinetics', 'Mathematics', 'Metabolism', 'Models, Biological'] | 2,082,915 | [['L01.224.160'], ['D08.811'], ['E05.337', 'N05.715.360.335'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['G03'], ['E05.599.395']] | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
New prospects in the detection and comparative analysis of hybridization in the tree of life. | Assessing the relative importance of the various pathways to diversification is a central goal of biodiversity researchers. For plant biologists, and increasingly across the spectrum of biological sciences, among these pathways of interest is hybridization. New methodological developments are moving the field away from... | ['Biodiversity', 'Evolution, Molecular', 'Genetic Loci', 'Genetic Speciation', 'Genome, Plant', 'Genomics', 'Hybridization, Genetic', 'Phylogeny', 'Plants'] | 29,683,488 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.380'], ['G05.045.350', 'G16.075.350'], ['G05.360.340.365'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['E05.820.150.390', 'G05.090.390'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.650']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Associations Between Breastfeeding Initiation and Infant Mortality in an Urban Population. | Background: Breastfeeding promotion and support are not universally accepted in the United States as a strategy to reduce infant mortality. We investigated associations between breastfeeding and infant mortality in an urban population with high infant mortality and low breastfeeding rates. Methods: A retrospective epid... | ['Adult', 'Breast Feeding', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Promotion', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Newborn', 'Male', 'Odds Ratio', 'Pregnancy', 'Retrospective Studies', 'Risk Factors', 'Tennessee', 'Urban Population'] | 31,210,534 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['F01.100.150.500', 'N05.300.150.410'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.50... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Importance of prenatal detection of hydronephrosis of the upper pole. | To determine the impact of prenatal detection on neonates with hydronephrosis of the upper pole of a duplex collecting system, we reviewed 40 such cases seen between June 1982 and April 1989. This six-per-year rate contrasts with fewer than one case per year that was seen at our hospital from 1947 to 1977. Nineteen pat... | ['Humans', 'Hydronephrosis', 'Infant, Newborn', 'Kidney', 'Prenatal Diagnosis', 'Prospective Studies', 'Radionuclide Imaging', 'Ultrasonography', 'Ureterocele', 'Urography', 'Vesico-Ureteral Reflux'] | 2,112,833 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.307', 'C13.351.968.419.307'], ['M01.060.703.520'], ['A05.810.453'], ['E01.370.378.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.710', 'E01.370.384.730'], ['E01.370.350.850'], ['C12.777.725.8... | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MRI of female genital and pelvic organs during sexual arousal. | We utilized contrast enhanced magnetic resonance imaging (MRI) to delineate the anatomy of the female genital and pelvic organs during sexual arousal. Eleven healthy pre-menopausal women and eight healthy post-menopausal women underwent MRI of the pelvis while watching an erotic video. A 1.5 Tesla MR system was used to... | ['Adult', 'Erotica', 'Female', 'Genitalia, Female', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Pelvis', 'Photic Stimulation', 'Postmenopause', 'Premenopause', 'Sexual Behavior', 'Surveys and Questionnaires'] | 15,715,038 | [['M01.060.116'], ['K01.517.414', 'L01.178.682.441'], ['A05.360.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A01.923.600'], ['E05.723.729'], ['G08.686.157.500.625', 'G08.686.841.249.500.625'], ['G08.686.157.500.812', 'G08.686.841.249.500.812'], ['F01.145.802'],... | ['Named Groups [M]', 'Humanities [K]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Live broadcast lectures on complete denture prosthodontics at Tokyo Medical and Dental University: comparison of two years. | A live broadcasting system was developed as part of dental education with Information and Communication Technology (ICT) at Tokyo Medical and Dental University. The purpose of this study was to utilize this system in complete denture prosthodontics, especially for the procedure of making a definitive impression with cu... | ['Adult', 'Dental Impression Technique', 'Denture, Complete', 'Education, Dental', 'Educational Technology', 'Female', 'Humans', 'Male', 'Program Evaluation', 'Prosthodontics', 'Schools, Dental', 'Surveys and Questionnaires', 'Tokyo', 'Video Recording'] | 23,486,896 | [['M01.060.116'], ['E06.912.130'], ['E06.780.346.760.775', 'E07.695.190.200.205'], ['I02.358.274'], ['J01.897.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['E06.780', 'H02.163.876.708'], ['I02.783.495.481'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.85... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Understanding the human salivary metabolome. | Saliva is a readily accessible biofluid that is important for the overall health, aiding in the chewing, swallowing, and tasting of food as well as the regulation mouth flora. As a first step to determining and understanding the human saliva metabolome, we have measured salivary metabolite concentrations under a variet... | ['Adult', 'Aged', 'Female', 'Humans', 'Male', 'Metabolome', 'Middle Aged', 'Multivariate Analysis', 'Nuclear Magnetic Resonance, Biomolecular', 'Saliva', 'Sex Factors', 'Smoking'] | 19,259,987 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.500'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E05.196.867.519.550'], ['A12.200.666'], ['N05.715.350.675', 'N06.850.490.875'], ['F01.145.805']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The importance of observation versus process error in analyses of global ungulate populations. | Population abundance data vary widely in quality and are rarely accurate. The two main components of error in such data are observation and process error. We used Bayesian state space models to estimate the observation and process error in time-series of 55 globally distributed populations of two species, Cervus elaphu... | ['Animals', 'Bayes Theorem', 'Deer', 'Geography', 'Markov Chains', 'Models, Statistical', 'Population Dynamics'] | 24,201,239 | [['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.500.380.373'], ['H01.277.500'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500', 'N06.850.520.830.996.500']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Prevalence and significance of acanthosis nigricans in an adult obese population. | BACKGROUND AND DESIGN: Acanthosis nigricans develops commonly in obese individuals, yet its prevalence and significance in an unselected adult obese population has not been determined. To address these issues, 34 patients enrolled in the Adult Obesity Clinic at Parkland Memorial Hospital (Dallas, Tex) were chosen at ra... | ['Acanthosis Nigricans', 'Blood Glucose', 'Cohort Studies', 'Female', 'Humans', 'Insulin', 'Male', 'Obesity', 'Prevalence', 'Sampling Studies', 'Texas'] | 1,626,961 | [['C17.800.621.430.530.100'], ['D09.947.875.359.448.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.1... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells. | UNLABELLED: Transcription factors of the far-upstream element-binding protein (FBP) family represent cellular pathway hubs, and their overexpression in liver cancer (hepatocellular carcinoma [HCC]) stimulates tumor cell proliferation and correlates with poor prognosis. Here we determine the mode of oncogenic FBP overex... | ['Carcinoma, Hepatocellular', 'Caspase 3', 'Caspase 7', 'DNA Helicases', 'DNA-Binding Proteins', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'Phosphatidylinositol 3-Kinases', 'Protein Stability', 'Proto-Oncogene Proteins c-akt', 'RNA-Binding Proteins', 'TOR Serine-Threonine Kinases'] | 26,901,106 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.350.700', 'D08.811.277.656.300.200.126.350.700', 'D12.644... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethylene-induced transcriptional and hormonal responses at the onset of sugarcane ripening. | The effects of ethephon as a sugarcane ripener are attributed to ethylene. However, the role of this phytohormone at the molecular level is unknown. We performed a transcriptome analysis combined with the evaluation of sucrose metabolism and hormone profiling of sugarcane plants sprayed with ethephon or aminoethoxyviny... | ['Ethylenes', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Plant Development', 'Plant Growth Regulators', 'Saccharum', 'Sucrose'] | 28,266,527 | [['D02.455.326.271.367'], ['E05.393.332'], ['G05.308.375'], ['G07.345.625', 'G15.589'], ['D27.505.696.377.760'], ['B01.650.940.800.575.912.250.822.835'], ['D09.698.629.305.770', 'D09.947.750.770']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Manipulation of the coronavirus genome using targeted RNA recombination with interspecies chimeric coronaviruses. | Targeted RNA recombination has proven to be a powerful tool for the genetic engineering of the coronavirus genome, particularly in its 3' part. Here we describe procedures for the generation of recombinant and mutant mouse hepatitis virus and feline infectious peritonitis virus. Key to the two-step method is the effici... | ['Animals', 'Cats', 'Coronavirus', 'Coronavirus, Feline', 'Genome, Viral', 'Mice', 'Models, Genetic', 'Murine hepatitis virus', 'RNA, Viral', 'Recombination, Genetic'] | 19,057,874 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B04.820.578.500.540.150'], ['B04.820.578.500.540.150.075.500.375'], ['G05.360.340.358.840'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395.397'], ['B04.450.580', 'B04.820.578.500.540.150.113.875'], ['D13.444.735.828'], ['G05.728']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ADAR2-dependent GluA2 editing regulates cocaine seeking. | Activation of AMPA receptors (AMPARs) in the nucleus accumbens is necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and relapse. AMPARs are tetrameric protein complexes that consist of GluA1-4 subunits, of which GluA2 imparts calcium permeability. Adenosine deaminase acting on... | ['Adenosine Deaminase', 'Animals', 'Calcium', 'Cocaine', 'Conditioning, Operant', 'Deoxyribonucleases, Type II Site-Specific', 'Dopamine Uptake Inhibitors', 'Drug-Seeking Behavior', 'Gene Expression Regulation', 'Male', 'Nucleus Accumbens', 'RNA Editing', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, AM... | 25,349,168 | [['D08.811.277.151.486.075'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['F02.463.425.179.509'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['D27.505.51... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanical manipulation of thrombus: coronary thrombectomy, intracoronary clot displacement, and transcatheter aspiration. | Recanalization of occluded arteries during acute myocardial infarction has been proven to prolong life and improve left ventricular function. Patients who could not receive thrombolytic therapy for failed thrombolysis and/or angioplasty were treated by mechanical manipulation of the thrombus. Three techniques were used... | ['Aged', 'Aged, 80 and over', 'Cardiac Catheterization', 'Coronary Thrombosis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Suction', 'Thrombectomy', 'Treatment Outcome'] | 8,279,346 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.48... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A conditioning lesion of the peripheral axons of dorsal root ganglion cells accelerates regeneration of only their peripheral axons. | Axotomy of the peripheral axon of dorsal root ganglion (DRG) cells is known to result in chromatolysis and changes in protein synthesis in DRG cells. We investigated whether a stimulus produced by peripheral branch axotomy would affect the regenerative properties of both the central and peripheral axon of the DRG cell ... | ['Animals', 'Axonal Transport', 'Axons', 'Ganglia, Spinal', 'Male', 'Nerve Crush', 'Nerve Regeneration', 'Nerve Tissue Proteins', 'Rats', 'Rats, Inbred Strains'] | 6,204,020 | [['B01.050'], ['G03.143.355.040', 'G04.392.040', 'G11.561.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['E04.525.210.560'], ['G11.561.585', 'G16.762.611'], ['D12.776.631'], ['B01.050.150.900.649.313.992.635.505.700'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The distinction of small cell and non-small cell lung cancer by growth in native-state histoculture. | Histological analysis remains the primary method of distinguishing between small cell (SCLC) and non-small cell lung cancer (NSCLC). This distinction has significant impact therapeutically because of their relative difference in chemoresponsiveness (J.D. Minna et al., Principles and Practice of Oncology, pp. 396-474, 1... | ['Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Small Cell', 'Humans', 'Lung Neoplasms', 'Tumor Cells, Cultured'] | 2,168,289 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C04.557.470.200.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A11.251.860']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy. | OBJECTIVE: To evaluate the efficacy and safety of vaginal misoprostol for cervical priming before diagnostic outpatient hysteroscopy (OH) without anesthesia.DESIGN: Double-blind randomized controlled trial.SETTING: University teaching hospital.PATIENT(S): One hundred fifty patients requiring diagnostic OH for investiga... | ['Administration, Intravaginal', 'Adult', 'Ambulatory Care', 'Cervix Uteri', 'Double-Blind Method', 'Female', 'Humans', 'Hysteroscopy', 'Infertility, Female', 'Misoprostol', 'Pain Measurement', 'Young Adult'] | 21,575,939 | [['E02.319.267.120.500'], ['M01.060.116'], ['E02.760.106', 'N02.421.585.106'], ['A05.360.319.679.256'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.378.330', 'E01.370.388.250.360', 'E04.502.250.360', 'E04.520.360', 'E04... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. | The morphologic features of trichofolliculoma are variable, reminiscent of the anagen, catagen, and telogen phases of a normal hair follicle in its cycle. We recently described an early, fully developed stage and late stages of trichofolliculoma. Using immunohistochemical examination, we sought to demonstrate hyperplas... | ['Adult', 'Child, Preschool', 'Female', 'Humans', 'Hyperplasia', 'Immunohistochemistry', 'Intermediate Filament Proteins', 'Keratin-20', 'Ki-67 Antigen', 'Male', 'Merkel Cells', 'Middle Aged', 'Neoplasms, Basal Cell', 'Skin', 'Skin Neoplasms', 'Time Factors'] | 10,027,518 | [['M01.060.116'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H0... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Electrophoretic types of rotavirus RNA during a 4-yr study of gastroenteritis in Tucum?n]. | Between May 1986 and November 1989 a total of 796 faecal samples obtained from children with symptoms of acute diarrhea were analyzed. Rotavirus (RV) was detected in 166 cases by polyacrylamide gel electrophoresis of the viral RNA (PAGE) (Fig. 1). This technique allowed us to identify 19 different electropherotypes (EP... | ['Argentina', 'Child, Preschool', 'Diarrhea, Infantile', 'Electrophoresis, Polyacrylamide Gel', 'Gastroenteritis', 'Humans', 'Infant', 'Infant, Newborn', 'RNA, Viral', 'Rotavirus', 'Rotavirus Infections'] | 1,966,305 | [['Z01.107.757.077'], ['M01.060.406.448'], ['C23.888.821.214.500'], ['E05.196.401.402', 'E05.301.300.319'], ['C06.405.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['D13.444.735.828'], ['B04.820.223.719.790'], ['C01.925.782.791.814']] | ['Geographicals [Z]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice. | Type 2 diabetes (T2DM) is a complex disease linked to pancreatic beta-cell failure and insulin resistance. Current antidiabetic treatment regimens for T2DM include insulin sensitizers and insulin secretagogues. We have previously demonstrated that leptolide, a member of the furanocembranolides family, promotes pancreat... | ['Adolescent', 'Animals', 'Anthozoa', 'Diabetes Mellitus, Type 2', 'Diet', 'Diterpenes', 'Furans', 'Hep G2 Cells', 'Humans', 'Hypoglycemic Agents', 'Insulin Resistance', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Obesity, Morbid'] | 28,914,811 | [['M01.060.057'], ['B01.050'], ['B01.050.500.308.237'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.203.650.240'], ['D02.455.849.291'], ['D03.383.312'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['B... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. | Alzheimer's disease neuropathology is characterized by key features that include the deposition of the amyloid beta peptide (Abeta) into plaques, the formation of neurofibrillary tangles, and the loss of neurons and synapses in specific brain regions. The loss of synapses, and particularly the associated presynaptic ve... | ['Age Factors', 'Alzheimer Disease', 'Amyloid beta-Peptides', 'Animals', 'Cerebral Cortex', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'Hippocampus', 'Immunohistochemistry', 'Immunotherapy', 'Mice', 'Mice, Transgenic', 'Nerve Degeneration', 'Peptides', 'Synapses', 'Synaptophysin'] | 16,207,868 | [['N05.715.350.075', 'N06.850.490.250'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A08.186.211.200.885.287.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.... | ['Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Self-assembly of natural light-harvesting bacteriochlorophylls of green sulfur photosynthetic bacteria in silicate capsules as stable models of chlorosomes. | Naturally occurring bacteriochlorophyll(BChl)s-c, -d, and -e from green sulfur photosynthetic bacteria were self-assembled in an aqueous solution in the presence of octadecyltriethoxysilane and tetraethoxysilane, followed by polycondensation of the alkoxysilanes by incubation for 50 h at 25 degrees C. The resulting BCh... | ['Bacteriochlorophylls', 'Chlorobi', 'Circular Dichroism', 'Metals', 'Silicates', 'Spectrometry, Fluorescence'] | 16,848,406 | [['D03.383.129.578.840.374.100', 'D03.633.400.909.374.100', 'D04.345.783.374.100', 'D12.776.752.249'], ['B03.250'], ['E05.196.867.151'], ['D01.552'], ['D01.578.725', 'D01.837.725.700.760'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of sub-inhibitory concentration of chlorhexidine on lipid and sterol composition of Candida albicans. | The effect of a sub-inhibitory concentration of chlorhexidine on lipid and sterol composition of Candida albicans was investigated. The total lipid content of this yeast grown in the presence of chlorhexidine was reduced whilst the total sterol content was increased compared with control-grown cells. Lipids and sterol ... | ['Anti-Infective Agents, Local', 'Candida albicans', 'Chlorhexidine', 'Chromatography, Thin Layer', 'Fatty Acids', 'Lipid Metabolism', 'Lipids', 'Sterols'] | 9,646,510 | [['D27.505.954.122.187'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['D02.078.370.141.100'], ['E05.196.181.400.537'], ['D10.251'], ['G03.458'], ['D10'], ['D04.210.500.247.808', 'D10.570.938']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Radiographic diagnosis of abdominal diseases in foals and ponys. II. Pathologic findings in 60 cases]. | A diagnostic approach based on clinical and radiographic examinations for evaluation of young foals and small ponies with acute abdominal discomfort is presented. Standing right to left lateral abdominal radiographs were taken of 54 foals and 6 ponies using a previously described technique. Interpretation of the radiog... | ['Abdomen', 'Abdominal Pain', 'Animals', 'Female', 'Horse Diseases', 'Horses', 'Male', 'Radiography, Abdominal'] | 2,219,108 | [['A01.923.047'], ['C23.888.592.612.054', 'C23.888.821.030'], ['B01.050'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['E01.370.350.700.715']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Orthogonal bone plate stabilization for limb-sparing surgery. | This report describes limb-sparing surgery in a 35 kg, six-year-old Hungarian Vizsla with a distal radial lytic bone lesion. Preoperative biopsy had suggested a bone cyst, however histopathology on the excised bone segment was indicative of an osteosarcoma. Following excision of the tumour, the bone defect was filled w... | ['Animals', 'Bone Neoplasms', 'Bone Plates', 'Bone Resorption', 'Dog Diseases', 'Dogs', 'Female', 'Forelimb', 'Limb Salvage', 'Osteosarcoma'] | 24,081,486 | [['B01.050'], ['C04.588.149', 'C05.116.231'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['C05.116.264', 'G11.427.213.150'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A13.395'], ['E04.100.814.603', 'E04.555.400', 'E04.680.350'], ['C04.557.450.565.575.650', 'C04.557.450.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of acute myelogenous leukemia in the older patient with attenuated high-dose ara-C. | We have evaluated the activity and toxicity of cytosine arabinoside (ara-C; 750 mg/m2 intravenously given over 3 hours every 12 hours for 12 doses) to induce remission in older (median age, 73 years) newly diagnosed patients who had acute myelogenous leukemia (AML). A maximum of two cycles of induction were administere... | ['Aged', 'Antimetabolites, Antineoplastic', 'Cytarabine', 'Drug Administration Schedule', 'Female', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Remission Induction', 'Survival Analysis'] | 9,537,199 | [['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['E02.860'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The emergence of temporal hyperacuity from widely tuned cell populations. | Typically, individual neural cells operate on a millisecond time scale yet behaviorally animals reveal sub-microsecond acuity. Our model resolves this huge discrepancy by using populations of many widely tuned cells to attain sub-microsecond resolution in a temporal discrimination task. An echolocating bat uses its aud... | ['Acoustic Stimulation', 'Animals', 'Auditory Cortex', 'Chiroptera', 'Computer Simulation', 'Discrimination, Psychological', 'Echolocation', 'Feedback', 'Models, Neurological', 'Neurons', 'Reaction Time', 'Signal Detection, Psychological', 'Space Perception', 'Time Factors', 'Time Perception'] | 15,468,733 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['A08.186.211.200.885.287.500.814.249', 'A08.186.211.200.885.287.500.863.297'], ['B01.050.150.900.649.313.937'], ['L01.224.160'], ['F02.463.593.257'], ['F01.145.113.055.400'], ['L01.906.394.211'], ['E05.599.395.642'], ['A08.675', 'A11.671'], ['E05.796.817', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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